CN110393772A - A kind of pharmaceutical composition and preparation method promoting radiotherapy patient skin wound healing - Google Patents

A kind of pharmaceutical composition and preparation method promoting radiotherapy patient skin wound healing Download PDF

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CN110393772A
CN110393772A CN201910834978.0A CN201910834978A CN110393772A CN 110393772 A CN110393772 A CN 110393772A CN 201910834978 A CN201910834978 A CN 201910834978A CN 110393772 A CN110393772 A CN 110393772A
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pharmaceutical composition
wound healing
patient skin
skin wound
vitamin
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尹洪莉
何亮
杨宏英
关琼瑶
王庆喜
孙晓敏
马莉
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/288—Taraxacum (dandelion)
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    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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Abstract

The present invention discloses a kind of pharmaceutical composition for promoting radiotherapy patient skin wound healing, is related to skin healing technical field of pharmaceuticals.The pharmaceutical composition for promoting radiotherapy patient skin wound healing, is made of purslane 1-10g, dandelion 1-10g, Radix Astragali 1-10g, bletilla striata 1-10g, coptis 1-10g, Radix Notoginseng 1-10g, 8 × 10-6-20 of vitamin × 10-6g, zinc 0.01-0.02g, lactobacillus reuteri 2-10g, Lactobacillus rhamnosus 2-10g, chitosan 20-50g and dressing by weight；The vitamin is vitamin A, vitamin B compound and ascorbic one or more；The auxiliary material is medically acceptable auxiliary material, and auxiliary material accounting is no more than 30-50%.Radiation insult skin is smeared or be sprayed at after radiotherapy, patient skin can be promoted to heal, and is suitble to clinical application.

Description

A kind of pharmaceutical composition and preparation method promoting radiotherapy patient skin wound healing
Technical field
The present invention relates to skin healing technical field of pharmaceuticals, are specifically related to a kind of promotion radiotherapy patient skin wound healing Pharmaceutical composition and preparation method.
Background technique
Tumour radiotherapy is a kind of local therapeutic approaches using radiation cure tumour.Radioactive ray include that radioactivity is same Position element generate α, β, gamma-rays and all kinds of x-ray therapy apparatuses or accelerator generate x-ray, electric wire, proton beam and other Particle beams etc..About 70% cancer patient needs to use radiotherapy during treating cancer, and there are about 40% cancers can To be eradicated with radiotherapy.Effect and status of the radiotherapy in oncotherapy become increasingly conspicuous, it has also become treat the master of malignant tumour Want one of means.
During clinical radiotherapy, radioactive ray will necessarily generate certain influence to human normal tissue, to make At certain radioreaction and damage；Radiodermatitis less serious case can cause the localised skin pigmentation of patient, drying, furfur, It can cause to radiate wild skin when serious and erythema, cusalgia, sepage, ulcer occur, cause patient locally or systemically to infect, make in radiotherapy It is disconnected, psychology and economic pressures are increased, therapeutic effect is affected；Radiodermatitis is mainly since skin receives the object of high-energy Radioactive ray are managed, the epidermal dna molecule of coup injury human body makes the fracture of its hydrogen chain, single-stranded and double-strand break and formed to intersect Chain, the preceding cell after exposure dose reaches 20-40Gy in basal layer cannot generate neoblast, mature epithelial cell again It is lasting to lose, and the telangiectasis stasis of blood is bent, microthrombus formation causes ischemic necrosis etc. to change, and as a result epithelium is caused to strip off, Or even form ulcer；The grade scale of radiodermatitis: according to RTOG acute radiation injury grade scale, by radiation therapy process The skin injury of middle appearance is divided into 5 grades；0 grade: skin is unchanged；1 grade: the dark red spot of filter blister sample or alopecia, stemness decortication, perspiring subtracts It is few；2 grades: tenderness property or fresh color erythema, the moist decortication of sheet or intermediate edema；3 grades: the fusion at position is wet other than skinfold Property decortication, pitting edema；4 grades: ulcer, bleeding, necrosis.
Treating radiotherapy patient skin wound (radiodermatitis) includes preventative drug and curative drug, radioactivity skin Scorching radiotherapy uses preventive usage before starting, and avoids the degree that radiodermatitis or radiodermatitis occurs to mitigate as far as possible, at present Main preventive usage has the precious burn cream of aloe, U.S., mixed milk liquor, ray protectant, clean long-drawn-out mind, Trolamine cream； Therapeutic medication includes the drugs such as match skin profit, Soviet Union's skin gel ointment, the dedicated emulsifiable paste of radiotherapy and Mei Pikang, but after promoting radiotherapy In terms of skin healing, there is also certain limitations, cause effect ideal not to the utmost.
In conclusion problem of the existing technology: after tumor patient radiotherapy, radioactive ray are to human normal skin group Certain radioreaction and damage are weaved into, and lacks the drug for promoting radiotherapy patient skin wound healing in the prior art, Therapeutic effect is affected, increases psychology and economic pressures, while also increasing the pain of patient.
Summary of the invention
In view of the above-mentioned problems existing in the prior art, the present invention provides a kind of promotion radiotherapy patient skin wound healings Pharmaceutical composition is smeared or is sprayed at radiation insult skin after radiotherapy, patient skin can be promoted to heal, and clinical expansion is suitble to Using.
To realize above-mentioned technical purpose and the technique effect, the present invention is achieved through the following technical solutions:
A kind of pharmaceutical composition promoting radiotherapy patient skin wound healing, the promotion radiotherapy patient skin wound healing Pharmaceutical composition by weight by purslane 1-10g, dandelion 1-10g, Radix Astragali 1-10g, bletilla striata 1-10g, coptis 1-10g, three Seven 1-10g, vitamin 8 × 10-6-20×10-6G, zinc 0.01-0.02g, lactobacillus reuteri 2-10g, Lactobacillus rhamnosus 2- 10g and chitosan 20-50g composition.
Further, the pharmaceutical composition for promoting radiotherapy patient skin wound healing, by weight by purslane 2g, Pu Gong English 2g, Radix Astragali 2g, bletilla striata 2g, coptis 2g, Radix Notoginseng 2g, vitamin 9 × 10-6G, zinc 0.01g, lactobacillus reuteri 10g, rhamnose Lactobacillus 2g and chitosan 30g, composition.
Further, the pharmaceutical composition for promoting radiotherapy patient skin wound healing, by weight by purslane 8g, Pu Gong English 8g, Radix Astragali 8g, bletilla striata 8g, coptis 8g, Radix Notoginseng 8g, vitamin 15 × 10-6G, zinc 0.02g, lactobacillus reuteri 10g, sandlwood Sugared lactobacillus 2g and chitosan 50g composition.
Further, the vitamin is vitamin A, vitamin B compound and ascorbic one or more；
The purslane, dandelion, Radix Astragali, the bletilla striata, the coptis and Radix Notoginseng are purslane, dandelion, Radix Astragali, the bletilla striata, the coptis It is mentioned with the water of Radix Notoginseng or the extract of alcohol extracting；
The water mentions or alcohol extracting is that above-mentioned raw materials grind into powder after sieving, is weighed powder appropriate and is put into beaker It is subject to the ethyl alcohol or distilled water of certain proportion and concentration, carries out refluxing extraction after water-bath at a certain temperature and obtain above-mentioned raw materials Water mentions or the extract of alcohol extracting.
Further, the chitosan adds gelatin, and gelatin and chitosan dosage proportional region are 1.6-3.6, content of dispersion For 5-8%, medicine film dissolution time 20-30min, casting solution pH value is 5.5-6.4.
Another object of the present invention is to provide the pharmaceutical compositions of the promotion radiotherapy patient skin wound healing described in one kind The preparation method of object, the preparation method of the pharmaceutical composition for promoting radiotherapy patient skin wound healing, comprising the following steps:
Step 1: obtaining the extraction of purslane, dandelion, Radix Astragali, the bletilla striata, the coptis and Radix Notoginseng by water extraction or alcohol extracting method Object, concrete operations are after sieving, to weigh secretion appropriate and be put into beaker and be subject to certain proportion above-mentioned raw materials grind into powder With the ethyl alcohol or distilled water of concentration, refluxing extraction is carried out after water-bath at a certain temperature the water of above-mentioned raw materials is obtained to mention or alcohol extracting Extract；
It is uniformly mixed Step 2: said medicine extract is uniformly mixed and adds vitamin and zinc under the conditions of 4-10 DEG C Obtain mixture；
Step 3: using micro-emulsion technology or microcapsules technology, by said medicine mixture in conjunction with suitable chitosan, It is aided with the gelatin of proper proportion simultaneously and medicine film is made in auxiliary material.
Further, before the microemulsified and microcapsules, it is subject to lactobacillus reuteri in mixed liquor under the conditions of 4-10 DEG C It is 5.5-6.4 with Lactobacillus rhamnosus adjustment pH value, gelatin and chitosan dosage proportional region are 1.6-3.6, the drug containing of medicine film Amount is 5-8%.
Another object of the present invention is to provide the pharmaceutical compositions of the promotion radiotherapy patient skin wound healing described in one kind Application of the object in the drug that preparation promotes radiotherapy patient skin wound healing.
Another object of the present invention is to provide a kind of medicine groups using above-mentioned promotion radiotherapy patient skin wound healing Close paste, aqua and the spray of object preparation.
Beneficial effects of the present invention: the pharmaceutical composition of promotion radiotherapy patient skin wound healing of the invention, by dent Amaranth, dandelion, Radix Astragali, the bletilla striata, the coptis, Radix Notoginseng, vitamin, zinc, lactobacillus reuteri, Lactobacillus rhamnosus, chitosan composition； Vitamin is vitamin A, vitamin B compound and ascorbic one or more；Purslane, dandelion, Radix Astragali, the bletilla striata, the coptis With Radix Notoginseng be purslane, dandelion, Radix Astragali, the bletilla striata, the coptis and Radix Notoginseng water mention or the extract of alcohol extracting；With utilize microemulsified Technology or microcapsules technology by the extract of drug in conjunction with suitable chitosan, while being aided with the gelatin of proper proportion and auxiliary Medicine film is made in material；Not only the bioactivity of chitosan itself had been maintained, but also has been that important effective component is efficient, is sustained absorption；By above-mentioned Drug extract is molding with chitosan, it forms a film conveniently, naturally with spraying, sustained release is efficient, covering is abundant, permeability is strong, It is easy to attract, accelerates healing, radiotherapy patient skin wound healing can be effectively facilitated.
Certainly, it implements any of the products of the present invention and does not necessarily require achieving all the advantages described above at the same time.
Detailed description of the invention
In order to illustrate the technical solution of the embodiments of the present invention more clearly, will be described below to embodiment required Attached drawing is briefly described, it should be apparent that, drawings in the following description are only some embodiments of the invention, for ability For the those of ordinary skill of domain, without creative efforts, it can also be obtained according to these attached drawings other attached Figure.
Fig. 1 is the preparation method stream of the pharmaceutical composition of promotion radiotherapy patient skin wound healing described in the embodiment of the present invention Cheng Tu；
Specific embodiment
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete Site preparation description, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.It is based on Embodiment in the present invention, it is obtained by those of ordinary skill in the art without making creative efforts all other Embodiment shall fall within the protection scope of the present invention.
Application principle of the invention is explained in detail with reference to the accompanying drawing.
A kind of pharmaceutical composition promoting radiotherapy patient skin wound healing, the promotion radiotherapy patient skin wound healing Pharmaceutical composition by weight by purslane 1-10g, dandelion 1-10g, Radix Astragali 1-10g, bletilla striata 1-10g, coptis 1-10g, three Seven 1-10g, vitamin 8 × 10-6-20×10-6G, zinc 0.01-0.02g, lactobacillus reuteri 2-10g, Lactobacillus rhamnosus 2- 10g and chitosan 20-50g composition.
The pharmaceutical composition for promoting radiotherapy patient skin wound healing, by weight by purslane 2g, dandelion 2g, Huang Stilbene 2g, bletilla striata 2g, coptis 2g, Radix Notoginseng 2g, vitamin 9 × 10-6G, zinc 0.01g, lactobacillus reuteri 10g, Lactobacillus rhamnosus 2g and chitosan 30g, composition.
The pharmaceutical composition for promoting radiotherapy patient skin wound healing, by weight by purslane 8g, dandelion 8g, Huang Stilbene 8g, bletilla striata 8g, coptis 8g, Radix Notoginseng 8g, vitamin 15 × 10-6G, zinc 0.02g, lactobacillus reuteri 10g, Lactobacillus rhamnosus 2g and chitosan 50g composition.
The vitamin is vitamin A, vitamin B compound and ascorbic one or more；
The purslane, dandelion, Radix Astragali, the bletilla striata, the coptis and Radix Notoginseng are purslane, dandelion, Radix Astragali, the bletilla striata, the coptis It is mentioned with the water of Radix Notoginseng or the extract of alcohol extracting；
The water mentions or alcohol extracting is that above-mentioned raw materials grind into powder after sieving, is weighed secretion appropriate and is put into beaker It is subject to the ethyl alcohol or distilled water of certain proportion and concentration, carries out refluxing extraction after water-bath at a certain temperature and obtain above-mentioned raw materials Water mentions or the extract of alcohol extracting.
Further, the chitosan adds gelatin, and gelatin and chitosan dosage proportional region are 1.6-3.6, content of dispersion For 5-8%, medicine film dissolution time 20-30min, casting solution pH value is 5.5-6.4.
The pharmacological action of Chinese medicine is as follows in the embodiment of the present invention:
Purslane: acid is trembled with fear, nontoxic；It is respectful to say: acrid in flavour and warm in nature；Ancestor says: people eats it more, right cunning cold in nature；Have clearing heat and detoxicating, cool blood is stopped The function of blood.
Dandelion: sweet and neutral, it is nontoxic；Has the benefits of clearing heat and detoxicating, dispersing swelling and dissipating binds, promoting urination and stopping pain.
Radix Astragali: sweet, tepor；Tool tonifying Qi and lifting yang, strengthening exterior and reducing sweat, inducing diuresis for removing edema, shengjin nourishing, the stagnant arthritis of row, pus draining and toxin expelling, The benefits of expelling pus and promoting granulation.
The bletilla striata: it is bitter, sweet, puckery, it is slightly cold；The benefits of Bearberry Extract hemostasis, detumescence and promoting granulation；For spitting blood, haematemesis, traumatic hemorrhage, sore Ulcer pyogenic infections, chapped skin.
The coptis: it is bitter, it trembles with fear, it is nontoxic；Have heat-clearing and damp-drying drug, antibacterial of reducing swelling, the function of purging fire for removing toxin.
Radix Notoginseng: sweet, slight bitter, temperature are nontoxic；Has the benefits of dissipating stasis and stanching bleeding, detumescence ding-tong；
Vitamin is vitamin A, vitamin B compound and vitamin C in the embodiment of the present invention, and vitamin A, which has, to be adjusted Epidermis and effect of cuticula metabolism can remove wrinkle with anti-aging；Help to protect epidermis, mucous membrane not by bacterial infestation, Healthy skin prevents cutaneum carcinoma；Vitamin B compound can treat pellagra and promote wound healing；Vitamin C participates in collagen Synthesis, facilitates the healing of human body wound, facilitates the diffusion for preventing cancer cell, improves the immunity of human body and improves sterilization energy Power.
Growth of the zinc with the synthesis of nucleic acid and protein and to cell in the embodiment of the present invention, can maintain epithelial The normal bonding of tissue promotes wound healing.
Lactobacillus reuteri in the embodiment of the present invention is colonized extensively in the tissue such as human gastrointestinal tract, the urinary tract, skin, With rush health benefit；The antimicrobial molecules such as organic acid, the Roche rhzomorph that the bacteroid generates can inhibit pathogenic microorganism field planting, change Become host's symbiosis Bacterial community；Part bacterial strain can promote regulatory T cells development, reduce proinflammatory cytokine generation, promote place Main immune system health；
Lactobacillus rhamnosus in the embodiment of the present invention: having efficient norcholesterol, enhances human autoimmune's ability, row Except toxin, promote cell division effect.
Chitosan in the embodiment of the present invention: chitosan can inhibit cancer metastasis, because chitosan has natural bacteriostatic activity, Its bioactivity and the bacteriostasis for having wide spectrum to multiple types bacterium and fungi, while in the present invention, chitosan is in Have certain clarification in medicament extract, effective ingredient can be retained, and remove impurity, as film in use, Because being added to lactobacillus reuteri and Lactobacillus rhamnosus, chitosan has apparent mucosa adhesion under acidic environment, and And there are also infiltration effect is protected, since the permeability of chitosan non-woven fabrics is relatively good, and there is obvious work in large area burn and scald With；Chitosan has analgesic, hemostasis, promotes wound healing, reduces scar, antibacterial, good physiological compatibility and biology simultaneously The excellent properties such as degradability, are highly suitable as wound healing, have good affinity interaction to wound surface, it is most important that It acts on clearly the increment of skin.
Application effect of the invention is described in detail below with reference to embodiment.
Embodiment 1
As shown in Figure 1, promoting the preparation side of the pharmaceutical composition of radiotherapy patient skin wound healing in the embodiment of the present invention Method, comprising the following steps:
Step 1: obtaining the extraction of purslane, dandelion, Radix Astragali, the bletilla striata, the coptis and Radix Notoginseng by water extraction or alcohol extracting method Object, concrete operations are after sieving, to weigh secretion appropriate and be put into beaker and be subject to certain proportion above-mentioned raw materials grind into powder With the ethyl alcohol or distilled water of concentration, refluxing extraction is carried out after water-bath at a certain temperature the water of above-mentioned raw materials is obtained to mention or alcohol extracting Extract；
It is uniformly mixed Step 2: said medicine extract is uniformly mixed and adds vitamin and zinc under the conditions of 4-10 DEG C Obtain mixture；
Step 3: using micro-emulsion technology or microcapsules technology, by said medicine mixture in conjunction with suitable chitosan, It is aided with the gelatin of proper proportion simultaneously and medicine film is made in auxiliary material.
Before the microemulsified and microcapsules, lactobacillus reuteri and Lactobacillus rhamnosus adjustment pH value are subject in mixed liquor For 5.5-6.4, gelatin and chitosan dosage proportional region are 1.6-3.6, and the content of dispersion of medicine film is 5-8%.
It is mentioned first by water or alcohol extracting method carries out the purslane of the application, dandelion, Radix Astragali, the bletilla striata, the coptis and Radix Notoginseng It extracts and obtains extract, the extract obtained usually using alcohol extracting method is more preferable；
Remaining component is mixed in extract, while adding lactobacillus reuteri pH related to Lactobacillus rhamnosus adjusting Value, chitosan and gelatin, one side chitosan are proportionally added in mixed liquor certain clarification in Chinese medical extract Effect, effective ingredient can be retained, and remove impurity, be prepared as film, In using micro-emulsion technology or microcapsules technology As film in use, because being added to lactobacillus reuteri and Lactobacillus rhamnosus, chitosan has obviously under acidic environment Mucosa adhesion, and there are also protect infiltration effect, since the permeability of chitosan non-woven fabrics is relatively good.
Embodiment 2
The pharmaceutical composition of promotion radiotherapy patient skin wound healing of the invention, by weight by purslane 2g, dandelion 2g, Radix Astragali 2g, bletilla striata 2g, coptis 2g, Radix Notoginseng 2g, vitamin 9 × 10-6G, zinc 0.01g, lactobacillus reuteri 10g, rhamnose cream Bacillus 2g and chitosan 30g；By the preparation side of the pharmaceutical composition of the promotion radiotherapy patient skin wound healing of above-described embodiment 1 Method prepares film；
The vitamin is vitamin A, vitamin B compound and ascorbic one or more；
The purslane, dandelion, Radix Astragali, the bletilla striata, the coptis and Radix Notoginseng are purslane, dandelion, Radix Astragali, the bletilla striata, the coptis It is mentioned with the water of Radix Notoginseng or the extract of alcohol extracting；
When in use, it is sprayed at radiotherapy patient skin wound, energy rapid film formation promotes wound healing, drug is promoted to inhale It receives, while inhibiting bacterium.
Embodiment 3
The pharmaceutical composition of promotion radiotherapy patient skin wound healing of the invention, by weight by purslane 8g, dandelion 8g, Radix Astragali 8g, bletilla striata 8g, coptis 8g, Radix Notoginseng 8g, vitamin 15 × 10-6G, zinc 0.02g, lactobacillus reuteri 10g, rhamnose Lactobacillus 2g and chitosan 50g composition, by the pharmaceutical composition of the promotion radiotherapy patient skin wound healing of above-described embodiment 1 Preparation method prepares film.
The vitamin is vitamin A, vitamin B compound and ascorbic one or more；
The purslane, dandelion, Radix Astragali, the bletilla striata, the coptis and Radix Notoginseng are purslane, dandelion, Radix Astragali, the bletilla striata, the coptis It is mentioned with the water of Radix Notoginseng or the extract of alcohol extracting.
Embodiment 4
Zoopery
The foundation of mouse X-ray radiodermatitis animal model
Irradiate instrument: Varian 600C electron linear accelerator, radiation quality and energy: 6MV X-ray, dosage rate are 400MU/min, dose uniformity are ± 3.0%；
Experimental animal, 8 week old female mices, breeding observing 3 days before making；
The 6MV X-ray that applying electronic linear accelerator generates establishes the acute radiodermatitis animal model of mouse, according to More experimental animals of secondary irradiation, simulated emission dermatitis；
According to RTOG acute radiation injury grade scale, the skin injury occurred in radiation therapy process is divided into 5 grades；0 Grade: skin is unchanged；1 grade: the dark red spot of filter blister sample or alopecia, are perspired and are reduced at stemness decortication；2 grades: tenderness property or fresh color erythema, The moist decortication of sheet or intermediate edema；3 grades: the moist decortication of the fusion at position, pitting edema other than skinfold；4 grades: bursting Ulcer, bleeding, necrosis；
Every kind of skin injury is prepared according to above-mentioned standard and is classified several animals, should be 3 multiple, such as 9,12；
The animal model for the different skin injury scale being prepared is uniformly divided into two groups:
First group: carrying out conventional simple dressing, do not use any drug；
Second group: carrying out smearing promotion using match skin profit, Soviet Union's skin gel ointment, the dedicated emulsifiable paste of radiotherapy and Mei Pikang etc. respectively Skin healing；
Third group: using promotion radiotherapy patient skin wound healing of the invention pharmaceutical composition be sprayed at affected part at Film；
Described second group experimental animal is divided equally and is distributed；
It above-mentioned two groups of zoopery medications 15-20 days, observes and counts daily the skin healing situation of every group of animal and do Statistics；Observation includes the red and swollen surface of a wound, infection and incrustation situation, and healing early stage, whether there is or not exudations, bleeding, later period wound healing and scar The formation such as trace, and shooting record surface of a wound size daily, calculate surface of a wound area using ImagePro software, and compare with before medication Compared with, calculate every animal each Wound healing rate very:
The surface of a wound observes situation statistics such as following table
Surface of a wound situation of change after each drug therapy of table 1
Remarks: " Mei Pikang " is foam dressing, and radiotherapy when does not allow application of dressings, therefore is not included in；
Product x100% before product/medication behind wound healing percentage=medication
Wound healing rate statistics such as the following table 2:
2 Wound healing rate statistical form of table
The advantages of formula provided by the invention is skin injury, the granulation growth, wound healing aspect effect to 3 grades or more It is relatively good, the recovery of skin normal flora can be promoted, to further promote the healing of skin wound；It can inhibit to cause simultaneously The growth of germ has certain anti-infectious function, while film has certain waterproofness, has certain waterproof antibacterial wound Effect.
Present invention disclosed above preferred embodiment is only intended to help to illustrate the present invention.There is no detailed for preferred embodiment All details are described, are not limited the invention to the specific embodiments described.Obviously, according to the content of this specification, It can make many modifications and variations.These embodiments are chosen and specifically described to this specification, is in order to better explain the present invention Principle and practical application, so that skilled artisan be enable to better understand and utilize the present invention.The present invention is only It is limited by claims and its full scope and equivalent.

Claims (9)

1. a kind of pharmaceutical composition for promoting radiotherapy patient skin wound healing, it is characterised in that: the promotion radiotherapy patient skin The pharmaceutical composition of skin wound healing is by weight by purslane 1-10g, dandelion 1-10g, Radix Astragali 1-10g, bletilla striata 1-10g, Huang Even 1-10g, Radix Notoginseng 1-10g, vitamin 8 × 10-6-20×10-6G, zinc 0.01-0.02g, lactobacillus reuteri 2-10g, sandlwood Sugared lactobacillus 2-10g and chitosan 20-50g composition.
2. promoting the pharmaceutical composition of radiotherapy patient skin wound healing as described in claim 1, it is characterised in that: the rush Into the pharmaceutical composition of radiotherapy patient skin wound healing, by weight by purslane 2g, dandelion 2g, Radix Astragali 2g, bletilla striata 2g, Huang Even 2g, Radix Notoginseng 2g, vitamin 9 × 10-6G, zinc 0.01g, lactobacillus reuteri 10g, Lactobacillus rhamnosus 2g and chitosan 30g, Composition.
3. promoting the pharmaceutical composition of radiotherapy patient skin wound healing as described in claim 1, it is characterised in that: the rush Into the pharmaceutical composition of radiotherapy patient skin wound healing, by weight by purslane 8g, dandelion 8g, Radix Astragali 8g, bletilla striata 8g, Huang Even 8g, Radix Notoginseng 8g, vitamin 15 × 10-6G, zinc 0.02g, lactobacillus reuteri 10g, Lactobacillus rhamnosus 2g and chitosan 50g Composition.
4. promoting the pharmaceutical composition of radiotherapy patient skin wound healing as described in claim 1, it is characterised in that: the dimension Raw element is vitamin A, vitamin B compound and ascorbic one or more；
The purslane, dandelion, Radix Astragali, the bletilla striata, the coptis and Radix Notoginseng are purslane, dandelion, Radix Astragali, the bletilla striata, the coptis and three Seven water mentions or the extract of alcohol extracting；
The water mentions or alcohol extracting is that above-mentioned raw materials grind into powder after sieving, is weighed powder appropriate and is put into beaker and be subject to The ethyl alcohol or distilled water of certain proportion and concentration, the water for carrying out refluxing extraction acquisition above-mentioned raw materials after water-bath at a certain temperature mention Or the extract of alcohol extracting.
5. promoting the pharmaceutical composition of radiotherapy patient skin wound healing as described in claim 1, it is characterised in that: the shell Glycan adds gelatin, and gelatin and chitosan dosage proportional region are 1.6-3.6, content of dispersion 5-8%, medicine film dissolution time 20- 30min, casting solution pH value are 5.5-6.4.
6. a kind of preparation method of the pharmaceutical composition as described in claim 1 for promoting radiotherapy patient skin wound healing, It is characterized in that, the preparation method of the pharmaceutical composition for promoting radiotherapy patient skin wound healing, comprising the following steps:
Step 1: obtaining the extract of purslane, dandelion, Radix Astragali, the bletilla striata, the coptis and Radix Notoginseng by water extraction or alcohol extracting method；
Step 2: prepare appropriate chitosan sequentially adds purslane, dandelion, Radix Astragali, the bletilla striata, the coptis and Radix Notoginseng at normal temperature Extract, which is uniformly mixed, obtains mixture；
Step 3: adding vitamin and zinc in obtained mixture, while lactobacillus reuteri is added under the conditions of 4-10 DEG C It is uniformly mixed with Lactobacillus rhamnosus and obtains pharmaceutical composition and stored refrigerated；
Step 4: adding appropriate auxiliary material in stored refrigerated pharmaceutical composition, it is prepared as paste, aqua or spray sealed, sterile Packaging.
7. a kind of utilize the pharmaceutical composition for promoting radiotherapy patient skin wound healing described in claim 1~6 any one The paste of preparation.
8. a kind of utilize the pharmaceutical composition for promoting radiotherapy patient skin wound healing described in claim 1~6 any one The aqua of preparation.
9. a kind of utilize the pharmaceutical composition for promoting radiotherapy patient skin wound healing described in claim 1~6 any one The spray of preparation.
CN201910834978.0A 2019-09-05 2019-09-05 A kind of pharmaceutical composition and preparation method promoting radiotherapy patient skin wound healing Pending CN110393772A (en)

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Application publication date: 20191101