CN110389121A - Multifocal Structured Illumination fluoroscopic imaging systems - Google Patents
Multifocal Structured Illumination fluoroscopic imaging systems Download PDFInfo
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- CN110389121A CN110389121A CN201910674968.5A CN201910674968A CN110389121A CN 110389121 A CN110389121 A CN 110389121A CN 201910674968 A CN201910674968 A CN 201910674968A CN 110389121 A CN110389121 A CN 110389121A
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- 238000003384 imaging method Methods 0.000 title claims abstract description 22
- 238000005286 illumination Methods 0.000 title claims abstract description 20
- 230000003287 optical effect Effects 0.000 claims abstract description 85
- 239000013307 optical fiber Substances 0.000 claims abstract description 7
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims description 10
- 229910052710 silicon Inorganic materials 0.000 claims description 10
- 239000010703 silicon Substances 0.000 claims description 10
- 239000010453 quartz Substances 0.000 claims description 8
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 8
- 238000003475 lamination Methods 0.000 claims description 6
- 238000006073 displacement reaction Methods 0.000 claims description 3
- 230000005611 electricity Effects 0.000 claims description 3
- 239000011159 matrix material Substances 0.000 claims description 3
- 230000004446 light reflex Effects 0.000 claims 1
- 239000010410 layer Substances 0.000 description 5
- 238000010586 diagram Methods 0.000 description 4
- 230000008901 benefit Effects 0.000 description 3
- 230000005284 excitation Effects 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 238000010276 construction Methods 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- 238000000799 fluorescence microscopy Methods 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000002356 single layer Substances 0.000 description 2
- 238000003491 array Methods 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000012632 fluorescent imaging Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000013011 mating Effects 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 238000012634 optical imaging Methods 0.000 description 1
- 230000002186 photoactivation Effects 0.000 description 1
- 230000011514 reflex Effects 0.000 description 1
- 238000009738 saturating Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
- G01J3/12—Generating the spectrum; Monochromators
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
- G01J3/28—Investigating the spectrum
- G01J3/2823—Imaging spectrometer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
- G01J3/28—Investigating the spectrum
- G01J3/44—Raman spectrometry; Scattering spectrometry ; Fluorescence spectrometry
- G01J3/4406—Fluorescence spectrometry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6456—Spatial resolved fluorescence measurements; Imaging
- G01N21/6458—Fluorescence microscopy
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N2021/6463—Optics
Abstract
A kind of multifocal Structured Illumination fluoroscopic imaging systems a, comprising: light source；First optical chip, including an input terminal and multiple output ends, wherein input terminal is connect with light source by an optical fiber；Second optical chip, including multiple input terminals and multiple output ends, plurality of input terminal are connect with multiple output ends of the first optical chip by optical fiber one by one；One filter set is set on the optical path extended line of the second optical chip output end；One lens are set between the second optical chip and filter set；One object lens are set to the side of filter set, with the connecting line of filter set perpendicular to the connecting line of the second optical chip and filter set；One objective table, is set between object lens and filter set；One photodetector is set to the other side of filter set, with the connecting line of filter set perpendicular to the connecting line of the second optical chip and the filter set；One imaging len, is set between photodetector and filter set.
Description
Technical field
The present invention relates to a kind of fluorescence microimaging systems more particularly to a kind of multifocal Structured Illumination fluorescence imagings
System.
Background technique
Currently, there are many optical fluorescence micro-imaging techniques that can break through optical diffraction limit in the prior art, comprising:
Stimulated emission depletion microtechnic, photoactivation positioning microtechnic, random optical reconstruct microtechnic and Structured Illumination are aobvious
Microtechnology etc., wherein Structured Illumination used by Structured Illumination microtechnic is divided into sine streak, random patterns and more
Focal illumination.
In the existing technical solution for realizing multifocal Structured Illumination fluorescence imaging, spatial light modulator is mostly used to realize
The projection and scanning for exciting optical arrays dot matrix can accurately and quickly modulate the spy of excitation light field using spatial light modulator
Property, the dotted excitation of array is formed in sample surfaces, by translational lattice, realizes scanning sample imaging, and passes through corresponding image
The fluorescence super-resolution imaging of restructing algorithm realization sample.
Although based on spatial light modulator realize Structured Illumination have the advantages that fast and accurately, its device cost compared with
Height limits the microscopical extensive use of Structured Illumination super-resolution, in addition, using such scheme, it is also necessary to what is collimated
Laser beam is incident in spatial light modulator with feature angle, this increases the volume of system to a certain extent, while by
It is not high to the utilization rate of light energy in spatial light modulator itself to the diffraction effect of light.
Therefore, based on the above problem of the existing technology, it would be highly desirable to research and develop that a kind of capacity usage ratio is high, at low cost and structure
Compact optical imaging system.
Summary of the invention
(1) technical problems to be solved
The present invention provides a kind of multifocal Structured Illumination fluoroscopic imaging systems, at least partly to solve in existing method
Existing spatial light modulator is at high cost, capacity usage ratio is low and bulky disadvantage.
(2) technical solution
According to an aspect of the present invention, a kind of multifocal Structured Illumination fluoroscopic imaging systems are provided, comprising:
One light source, the light source are laser light source, and for emitting light beam, wavelength 400-1600nm, while the light source can
For the light source of single wavelength or the integrated optical source of multiple wavelength；
First optical chip, including an input terminal and multiple output ends, wherein the input terminal and the light source pass through a light
Fibre connection forms multi beam emergent light for the light beam to be carried out light splitting, and exports respectively from multiple output ends；
Second optical chip, including multiple input terminals and multiple output ends, wherein the multiple input terminal and first light
Multiple output ends of chip are connected one by one by optical fiber, for every beam emergent light of first optical chip to be divided into multi beam, and
It is exported respectively from multiple output ends, the output end face of second optical chip is plane, and emergent light is rectangular lattice output；
One filter set is set on the optical path extended line of the second optical chip output end, is used for second light
The emergent light of chip reflexes to object under test, meanwhile, the exciting light that object under test is reflected can pass through the filter set to light
Electric explorer；
One lens are set between second optical chip and filter set, defeated from second optical chip for collecting
Emergent light out；
One object lens are set to the side of the filter set, and the connecting line with the filter set is perpendicular to described
The connecting line of two optical chips and the filter set, for project exciting light and acquire object under test transmitting fluorescence；
One objective table is set on the focusing surface of the object lens, and for placing object under test, which is three-dimensional precise
Electricity driving displacement platform；
One photodetector is set to the other side of the filter set, vertical with the connecting line of the filter set
In the connecting line of second optical chip and the filter set, which can be configured to the CCD or CMOS of scientific research grade
Camera, for acquiring the multiframe fluorescent image for the article to be measured being placed on objective table；
One imaging len is set between the photodetector and the filter set, the fluorescence for object under test
Image formation is on the photodetector.
In further embodiment, first optical chip can be silicon base chip, nitridation silicon chip or PLC (planar
Lightwave circuit, planar optical waveguide) optical chip one kind, if the visible light that light source is single 400-800nm is for single
Photon fluorescence excitation, it is the infrared of single 800-1600nm that operation wavelength, which can be selected, in the nitridation silicon chip of visible light, such as light source
Light is excited for multiphoton fluorescence, and it is the light of multiple and different wavelength that work, which can be selected, in the silicon base chip of infrared wavelength, such as light source,
It is excited for multicolor fluorescence, the PLC chip insensitive to wavelength can be selected.
In further embodiment, second optical chip is the PLC optical chip of lamination, including multilayer quartz base plate,
Multiple light splitting waveguides are provided on each quartz base plate, each layer of the PLC optical chip of the lamination can be realized a branch of input
Light is divided into multi beam light output, and then realizes that rectangular lattice exports emergent light.
In further embodiment, the filter set includes an exciter filter, a dichroscope and a transmitting filter
Mating plate.
(3) beneficial effect
It can be seen from the above technical proposal that a kind of multifocal Structured Illumination fluoroscopic imaging systems benefit provided by the invention
With lamination PLC chip realize array point array projection, reduce build multifocal Structured Illumination fluoroscopic imaging systems at
This, while simplifying optical path；In addition, PLC chip is relative to spatial light modulator, the loss of the optical diffraction of class optical grating construction compared with
It is low, there is high capacity usage ratio.
Detailed description of the invention
Fig. 1 is a kind of structure chart of multifocal Structured Illumination fluoroscopic imaging systems of the embodiment of the present invention.
Fig. 2 is the schematic diagram of the optical waveguide of single layer in the second optical chip of system shown in Figure 1.
Fig. 3 is the schematic diagram in the second optical chip output section of system shown in Figure 1.
[description of symbols]
1- light source；The first optical chip of 2-；The second optical chip of 3-；4- lens；
5- filter set；6- object lens；7- objective table；8- imaging len；9- photodetector；
301- quartz base plate；302- is divided waveguide；
501- exciter filter；502- dichroscope；503- emits optical filter.
Specific embodiment
To make the objectives, technical solutions, and advantages of the present invention clearer, below in conjunction with specific embodiment, and reference
Attached drawing, the present invention is described in further detail.
In the present invention, " on being set to ... " or " on being pasted to ... " is for including straight with single or multiple inter-module
Connect contact relation.Moreover, ordinal number such as " first ", " second ", " No.1 " or " two used in specification and claims
Number " etc. words, to modify claimed component, itself and do not include and represent the component have it is any before ordinal number,
The sequence or the sequence in manufacturing method for not representing a certain component and another component, the use of these ordinal numbers are only used to make to have
One component of certain name is able to that clear differentiation can be made with another component with identical name.
The present invention provides a kind of multifocal Structured Illumination fluoroscopic imaging systems, utilize the first optical chip and the second smooth core
Piece realizes array light source, and is projected on object under test by lens and object lens, excites object under test fluorescence, passes through simultaneously
The accurate three-dimensional of objective table is mobile, realizes and uses the entire object under test of two-dimensional lattice optical scanning, then saturating using filter set, imaging
Mirror and photodetector realize the acquisition of multiframe fluorescent image, finally utilize respective image algorithm, realize the glimmering of object under test
Light super-resolution imaging.
Fig. 1 is a kind of structure chart of multifocal Structured Illumination fluoroscopic imaging systems of the embodiment of the present invention, as shown in Figure 1,
Include:
Light source 1, the light source 1 are laser light source, and wavelength 400-1600nm, in the present embodiment, the light source 1 can be single
The integrated optical source of the light source of one wavelength or multiple wavelength；
First optical chip 2, including an input terminal and multiple output ends, wherein the input terminal and the light source 1 pass through light
Fibre connection is exported for single beam incident light of the light source 1 to be divided into multi beam, and respectively from multiple output ends；In the present embodiment
In, the first optical chip 2 can be silicon base chip, nitridation silicon chip or PLC (planar lightwave circuit, plane light wave
Lead) one kind of optical chip, the visible light if light source 1 is single 400-800nm excites for single photon fluorescence, optional operating wave
The nitridation silicon chip in visible light is grown, the infrared light if light source 1 is single 800-1600nm is excited for multiphoton fluorescence, optional
Silicon base chip with work in infrared wavelength is excited such as the light that light source 1 is multiple and different wavelength for multicolor fluorescence, can be selected
The PLC chip insensitive to wavelength；
Second optical chip 3, including multiple input terminals and multiple output ends, wherein the multiple input terminal and first light
Multiple output ends of chip 2 are connected one by one by optical fiber, and the output end face of second optical chip 3 is plane, and emergent light is rectangle
Dot matrix output；In the present embodiment, the second optical chip 3 is the PLC optical chip of lamination, including multilayer quartz base plate 301, Mei Geshi
Multiple light splitting waveguides 302 are provided on English substrate 301, each layer of the second optical chip 3, which can be realized, is averaged single beam incident light
It is divided into multi beam outgoing light output, and then realizes that rectangular lattice exports emergent light.
Filter set 5 is set on the optical path extended line of 3 output end of the second optical chip, is used for second light
The emergent light of chip 3 refracts on the object under test of objective table 7, which includes exciter filter 501, dichroscope
502 and transmitting optical filter 503, meanwhile, the exciting light that object under test is reflected can pass through the filter set 5 to photodetector
9；
Lens 4 are set between second optical chip 3 and filter set 5, for collecting from second optical chip 3
The emergent light of output；
Object lens 6 are set to the side of the filter set 5, and the connecting line with the filter set 5 is perpendicular to described
The connecting line of two optical chips 3 and the filter set 5, for projecting exciting light and acquiring the fluorescence of object under test transmitting；
Objective table 7 is set on the focusing surface of the object lens 6, and for placing object under test, which is three-dimensional essence
Close electricity driving displacement platform, can carry out accurate three-dimensional movement, and the rectangular lattice light exported for realizing the second optical chip 3 is treated
Survey the 3-D scanning of object；
Photodetector 9 is set to the other side of the filter set 5, vertical with the connecting line of the filter set 5
In the connecting line of second optical chip 3 and the filter set 5, the photodetector 9 can be configured to scientific research grade CCD or
CMOS camera, for acquiring the multiframe fluorescent image for the article to be measured being placed on objective table 7；
Imaging len 8, is set between the photodetector 9 and the filter set 5, the fluorescence for object under test
Image formation is on the photodetector.
Referring again to Fig. 1, as shown in Figure 1, in the present embodiment, the first optical chip 2 includes 1 input terminal and N number of output
It holds (N >=16), that is, realizes the uniform light splitting of 1*N.
Fig. 2 is the schematic diagram of the optical waveguide of 3 single layers in the second optical chip of system shown in Figure 1, as shown in Fig. 2, the second light
Chip 3 includes N number of input terminal and N*N output end, is stacked by N layers of quartz base plate 301.Each layer of quartz base plate 301 is all
There is N number of light splitting waveguide 302, be able to achieve the uniform light splitting of 1*N, the output end of each layer of input terminal and the first optical chip 2 is one by one
It is corresponding, and connected by optical fiber.
Fig. 3 is the schematic diagram in the second optical chip 3 output section of system shown in Figure 1, as shown in figure 3, the second optical chip 3
Output section be plane, the plane perpendicular to optical path optical axis, and each output point by rectangular lattice distribution.
By above statement, aiming at the problems existing in the prior art and disadvantage, one kind provided in an embodiment of the present invention are more
Focus structure optical illumination fluoroscopic imaging systems, using lamination PLC chip realize array point array projection, reduce build it is multifocal
The cost of structure light lighting fluorescent imaging system, while simplifying optical path；In addition, PLC chip is relative to spatial light modulator,
The loss of the optical diffraction of class optical grating construction is lower, has high capacity usage ratio.
Particular embodiments described above has carried out further in detail the purpose of the present invention, technical scheme and beneficial effects
Describe in detail bright, it should be understood that the above is only a specific embodiment of the present invention, is not intended to restrict the invention, it is all
Within the spirit and principles in the present invention, any modification, equivalent substitution, improvement and etc. done should be included in protection of the invention
Within the scope of.
Claims (9)
1. a kind of multifocal Structured Illumination fluoroscopic imaging systems, comprising:
One light source, for emitting light beam；
First optical chip, including an input terminal and multiple output ends, wherein the input terminal and the light source are connected by an optical fiber
It connects, forms multi beam emergent light for the light beam to be carried out light splitting, and export respectively from multiple output ends；
Second optical chip, including multiple input terminals and multiple output ends, wherein the multiple input terminal and first optical chip
Multiple output ends connected one by one by optical fiber, for every beam emergent light of first optical chip to be divided into multi beam, and respectively
It is exported from multiple output ends；
One filter set is set on the optical path extended line of the second optical chip output end, is used for second optical chip
Emergent light reflex to object under test；
One lens are set between second optical chip and filter set, for collecting from second optical chip output
Emergent light；
One object lens are set to the side of the filter set, and the connecting line with the filter set is perpendicular to second light
The connecting line of chip and the filter set, for project exciting light and acquire object under test transmitting fluorescence；
One objective table is set on the focusing surface of the object lens, for placing object under test；
One photodetector is set to the other side of the filter set, and the connecting line with the filter set is perpendicular to institute
The connecting line for stating the second optical chip Yu the filter set, for acquiring the multiframe fluorescence for the object under test being placed on objective table
Image；
One imaging len is set between the photodetector and the filter set, the fluorescence signal for object under test
It is imaged on the photodetector.
2. system according to claim 1, wherein the light source is laser light source, wavelength 400-1600nm.
3. system according to claim 1, wherein the light source is the light source of single wavelength or the Integrated Light of multiple wavelength
Source.
4. system according to claim 1, wherein first optical chip include silicon base chip, nitridation silicon chip or
PLC optical chip.
5. system according to claim 1, wherein second optical chip is the PLC optical chip of lamination, including multilayer
Quartz base plate is provided with multiple light splitting waveguides on every layer of quartz base plate.
6. system according to claim 5, wherein the output end face of second optical chip is plane, emergent light is square
Shape dot matrix output.
7. system according to claim 1, wherein the objective table is three-dimensional precise electricity driving displacement platform.
8. system according to claim 1, wherein the filter set includes an exciter filter, a dichroscope and
One transmitting optical filter.
9. system according to claim 1, wherein the photodetector is CCD or CMOS camera.
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| CN201910674968.5A CN110389121A (en) | 2019-07-24 | 2019-07-24 | Multifocal Structured Illumination fluoroscopic imaging systems |
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| CN201910674968.5A CN110389121A (en) | 2019-07-24 | 2019-07-24 | Multifocal Structured Illumination fluoroscopic imaging systems |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110793633A (en) * | 2019-11-14 | 2020-02-14 | 北京理工大学 | Single-pixel multispectral calculation imaging system and imaging method based on bundled optical fibers |
| CN110824681A (en) * | 2019-11-04 | 2020-02-21 | 哈尔滨工业大学 | Non-scanning high super-resolution optical three-dimensional microscopic imaging method |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108897126A (en) * | 2018-08-09 | 2018-11-27 | 中国科学院半导体研究所 | A kind of fluoroscopic imaging systems |
| CN208374472U (en) * | 2018-05-31 | 2019-01-15 | 东莞理工学院 | A kind of the 3D printing laser and system of high-rate laser sintering |
| CN109490865A (en) * | 2018-12-11 | 2019-03-19 | 北京饮冰科技有限公司 | A kind of novel face battle array laser radar |
-
2019
- 2019-07-24 CN CN201910674968.5A patent/CN110389121A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN208374472U (en) * | 2018-05-31 | 2019-01-15 | 东莞理工学院 | A kind of the 3D printing laser and system of high-rate laser sintering |
| CN108897126A (en) * | 2018-08-09 | 2018-11-27 | 中国科学院半导体研究所 | A kind of fluoroscopic imaging systems |
| CN109490865A (en) * | 2018-12-11 | 2019-03-19 | 北京饮冰科技有限公司 | A kind of novel face battle array laser radar |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110824681A (en) * | 2019-11-04 | 2020-02-21 | 哈尔滨工业大学 | Non-scanning high super-resolution optical three-dimensional microscopic imaging method |
| CN110793633A (en) * | 2019-11-14 | 2020-02-14 | 北京理工大学 | Single-pixel multispectral calculation imaging system and imaging method based on bundled optical fibers |
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Application publication date: 20191029 |