CN110367277A - A kind of preparation and its application method of faintly acid hypochlorous acid thimerosal - Google Patents
A kind of preparation and its application method of faintly acid hypochlorous acid thimerosal Download PDFInfo
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- CN110367277A CN110367277A CN201910674576.9A CN201910674576A CN110367277A CN 110367277 A CN110367277 A CN 110367277A CN 201910674576 A CN201910674576 A CN 201910674576A CN 110367277 A CN110367277 A CN 110367277A
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
Abstract
The present invention provides the preparations and its application method of a kind of faintly acid hypochlorous acid thimerosal, mainly by adding buffer to the acid adjustment rich in hypochlorite solution and in solution, make it during adjusting pH value, it prevents acid excessive, cause to generate chlorine, the concentration for reducing effective chlorine, influences the effect of sterilization.It goes wrong present invention has an advantage that 1) can effectively reduce in production process, to improve production efficiency；2) all kinds of bacteriums, fungi and virus can effectively be killed；And large-scale air sterillization can be carried out, and the harmful substances such as chlorine and carcinogenic substance chloroform are not generated, it is harmless to environment and human body.
Description
Technical field
The present invention relates to a kind of preparation methods of thimerosal, and in particular to a kind of preparation side of faintly acid hypochlorous acid thimerosal
Method and its application method.
Background technique
With the development of society, people also increasingly pay attention to environmental sanitation disinfection.Currently, chlorine-containing disinfectant is because of its price
Cheap, excellent in sterilization effect, can meet the sterilization requirement of daily life, and the generally receiving by people.
Hypochlorous acid (HOCl) is a kind of weak acid that chlorine leach is formed in water, and industrially, HOCl is as household bleach
With the active constituent in detergent and it is well-known.In biology system, HOCl is also a kind of extremely strong oxidant, can be rapid
Attack the relevant molecule of a variety of physiology, including mercaptan, thioether, Ammonia, amino acid, nucleotide, destruction hematic acid and polyenoic acid.With
This simultaneously, weakly acidic HOCl is also extremely significant, including Escherichia coli, pseudomonas aeruginosa, rod-like stem to bactericidal effect
Bacterium, kerekou pneumonia uncle, Candida albicans etc., be exposed to 2 minutes in weakly acidic HOCl and be killed.
Under normal conditions, in the production process of faintly acid hypochlorous acid thimerosal, if the hydrionic amount of addition is excessive, water
Solution becomes highly acid, then can generate a large amount of chlorine, to reduce the content of effective chlorine, influences the pH value of solution, final shadow
Ring the effect of its disinfection and sterilization.Therefore, a kind of production process that can optimize faintly acid hypochlorous acid thimerosal is designed, is had emphatically
The practical significance wanted.
Summary of the invention
In view of the above technical problems, the present invention provides a kind of preparation of faintly acid hypochlorous acid thimerosal and its users
Method mainly adds buffer in the solution, and reduction pH value adjustment process appearance is acid excessive, causes to reduce the dense of effective chlorine
Degree.
Mainly realized by following technical solution:
A kind of preparation and its application method of faintly acid hypochlorous acid thimerosal, the preparation method of thimerosal, including it is as follows
Step:
(1) certain density effective chlorine and liquor natrii hypochloritis are taken, carries out being sufficiently mixed stirring, obtains solution A；
(2) it takes a small amount of buffer to be put into solution A, after being sufficiently mixed uniformly, obtains mixed solution B；
(3) it takes acid solution to carry out pH value adjusting to solution B, obtains solution C, and carry out detecting real-time prison to effective chlorine
It surveys.
Further, the concentration of the effective chlorine is 120-160mg/L, and the concentration of sodium hypochlorite is 200-240mg/L；Institute
The volume ratio for stating effective solutions of chlorine and liquor natrii hypochloritis is 1:1.
Further, the quality of the buffer is the 0.5-0.7% of solution A quality；The buffer be sodium bicarbonate,
One of sodium carbonate, saleratus are a variety of.
Further, hydrionic concentration is 10 in the acid solution-3-10-4mol/L；The acid solution is lemon
One of acid, dust technology, dilute hydrochloric acid are a variety of.
Further, the concentration of the effective chlorine in the solution C is 200-240mg/L, and the pH value of the solution C is 6-7,
The detection method of the effective chlorine is GB/T 5750-2006.
Further, the hypochlorous acid thimerosal can be by way of spraying or clean to region or part
Can all carry out disinfection the operation of sterilization.
The preparation and its application method of a kind of faintly acid hypochlorous acid thimerosal provided by the invention, mainly by acidity
The adjustment of solution and in solution add buffer effect, make it during adjusting pH value, prevent acidity it is excessive,
Cause to generate chlorine, reduces the concentration of effective chlorine, influence the effect of sterilization.
Beneficial effect
1. preparation method provided by the invention can be effectively reduced in production process and be asked by adding buffer
Topic, to improve production efficiency；
2. hypochlorous acid thimerosal provided by the invention, identical as the sterilization component of human leukocytes release, can be effective
Kill all kinds of bacteriums, fungi and virus；And large-scale air sterillization can be carried out, chlorine and carcinogenic substance chloroform are not generated
Etc. harmful substances, it is harmless to environment and human body.
Specific embodiment
With reference to embodiment, the present invention is further illustrated.But the present invention is not limited to following embodiments.
Embodiment 1
A kind of preparation and its application method of faintly acid hypochlorous acid thimerosal,
S1: effective solutions of chlorine (effective chlorine density 120mg/L) and the liquor natrii hypochloritis of 500mL of 500mL are taken
(sodium hypochlorite concentration is 150mg/L) is mixed evenly, and is stood, is obtained solution A；
S2: the mixture (mass ratio 2:1) for weighing 5g sodium bicarbonate and sodium carbonate is dissolved in solution A, is continued
After stirring, solution B is obtained；
S3: taking its pH value of certain citric acid solution is 4, carries out pH value to solution B and is adjusted to 6, obtains solution C, and right
Its effective chlorine density is measured, and the concentration of effective chlorine is in 200mg/L.
Embodiment 2
A kind of preparation and its application method of faintly acid hypochlorous acid thimerosal,
S1: effective solutions of chlorine (effective chlorine density 120mg/L) and the liquor natrii hypochloritis of 500mL of 500mL are taken
(sodium hypochlorite concentration is 150mg/L) is mixed evenly, and is stood, is obtained solution A；
S2: the mixture for weighing 5g sodium carbonate is dissolved in solution A, after continuing stirring, obtains solution B1；
S3: taking its pH value of certain dilute hydrochloric acid solution is 4, to solution B1It carries out pH value and is adjusted to 6, obtain solution C1, and it is right
Its effective chlorine density is measured, and the concentration of effective chlorine is in 160mg/L.
Embodiment 3
A kind of preparation and its application method of faintly acid hypochlorous acid thimerosal,
S1: effective solutions of chlorine (effective chlorine density 120mg/L) and the liquor natrii hypochloritis of 500mL of 500mL are taken
(sodium hypochlorite concentration is 150mg/L) is mixed evenly, and is stood, is obtained solution A；
S2: the mixture (mass ratio 2:1) for weighing 5g sodium bicarbonate and sodium carbonate is dissolved in solution A, is continued
After stirring, solution B is obtained2；
S3: taking its pH value of certain hydrochloric acid solution is 4, to solution B2It carries out pH value and is adjusted to 6, obtain solution C2, and to it
Effective chlorine density is measured, and the concentration of effective chlorine is in 180mg/L.
Solution C, solution C in comparative example 1, embodiment 2 and embodiment 31And solution C2Carry out disinfection test, molten
The bactericidal effect of liquid C is the most obvious, and bactericidal effect is as shown in the table:
Meanwhile security test: 1, skin injury irritation test (animal experiment) is carried out to solution C；2, ocular mucosae
Irritation test (animal experiment)；3, cell toxicity test LD50 > 200ppm, 30min (human cornea epithelial cell)；4, it sprays
Mist inhalation test (animal experiment).Security test test result is without exception.
Above embodiments are described in detail specific implementation process of the invention, but the present invention be not limited to it is described
Embodiment, those skilled in the art can make various same replacements, these same replacements are belonged in the application
In claimed range.
Claims (6)
1. a kind of preparation and its application method of faintly acid hypochlorous acid thimerosal, which is characterized in that the preparation of its thimerosal, including
Following steps:
(1) certain density effective chlorine and liquor natrii hypochloritis are taken, carries out being sufficiently mixed stirring, obtains solution A；
(2) it takes a small amount of buffer to be put into solution A, after being sufficiently mixed uniformly, obtains mixed solution B；
(3) it takes acid solution to carry out pH value adjusting to solution B, obtains solution C, and detection real-time monitoring is carried out to effective chlorine.
2. the preparation method and its application method of a kind of hypochlorous acid thimerosal according to claim 1, which is characterized in that step
Suddenly in (1), the concentration of the effective chlorine is 120-160mg/L, and the concentration of sodium hypochlorite is 200-240mg/L；The effective chlorine
The volume ratio of solution and liquor natrii hypochloritis are 1:1.
3. the preparation and its application method of a kind of faintly acid hypochlorous acid thimerosal according to claim 1, which is characterized in that
In step (2), the quality of the buffer is the 0.5-0.7% of solution A quality；The buffer be sodium bicarbonate, sodium carbonate,
One of saleratus is a variety of.
4. the preparation and its application method of a kind of faintly acid hypochlorous acid thimerosal according to claim 1, which is characterized in that
In step (3), hydrionic concentration is 10 in the acid solution-3-10-4mol/L；The acid solution is citric acid, dilute nitre
One of acid, dilute hydrochloric acid are a variety of.
5. the preparation and its application method of a kind of faintly acid hypochlorous acid thimerosal according to claim 1, which is characterized in that
In step (3), the concentration of the effective chlorine in the solution C is 200-240mg/L, and the pH value of the solution C is 6-7；It is described to have
The detection method for imitating chlorine is GB/T 5750-2006.
6. the preparation and its application method of a kind of faintly acid hypochlorous acid thimerosal according to claim 1, which is characterized in that
The hypochlorous acid thimerosal can pass through the operation by spraying or by way of scouring to region or the local sterilization that can all carry out disinfection.
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111150778A (en) * | 2020-02-26 | 2020-05-15 | 广州市白云区天芳化妆品厂 | A sterilizing disinfectant with high safety and high efficiency for oral mucosa, skin and general articles, and its preparation method |
| CN111232929A (en) * | 2020-03-24 | 2020-06-05 | 乔卫峰 | Equipment for preparing hypochlorous acid solution and hypochlorous acid solution preparation process |
| CN111346532A (en) * | 2020-03-13 | 2020-06-30 | 唐山市新概念科技有限公司 | Preparation method of carbonic acid-hypochlorous acid water |
| CN111937900A (en) * | 2020-08-20 | 2020-11-17 | 开平市美康泉生物科技有限公司 | High-stability molecular hypochlorous acid disinfectant and preparation method thereof |
| CN112262853A (en) * | 2020-10-21 | 2021-01-26 | 李永琴 | Preparation method of slightly acidic carbonic acid type hypochlorous acid water disinfectant |
| CN113907072A (en) * | 2021-09-09 | 2022-01-11 | 潍坊红阳药业有限公司 | Preparation method of high-precision weak acid hypochlorite disinfectant |
| CN114314514A (en) * | 2022-02-18 | 2022-04-12 | 华融化学股份有限公司 | Method for preparing hypochlorous acid from byproduct chlorine water |
| CN114796560A (en) * | 2021-05-26 | 2022-07-29 | 北京大学口腔医学院 | Method for sterilizing and drying oral impression |
| CN115282170A (en) * | 2022-08-11 | 2022-11-04 | 山东舒达生物科技有限公司 | Preparation method of powerful private lotion |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111150778A (en) * | 2020-02-26 | 2020-05-15 | 广州市白云区天芳化妆品厂 | A sterilizing disinfectant with high safety and high efficiency for oral mucosa, skin and general articles, and its preparation method |
| CN111346532A (en) * | 2020-03-13 | 2020-06-30 | 唐山市新概念科技有限公司 | Preparation method of carbonic acid-hypochlorous acid water |
| CN111232929A (en) * | 2020-03-24 | 2020-06-05 | 乔卫峰 | Equipment for preparing hypochlorous acid solution and hypochlorous acid solution preparation process |
| CN111937900A (en) * | 2020-08-20 | 2020-11-17 | 开平市美康泉生物科技有限公司 | High-stability molecular hypochlorous acid disinfectant and preparation method thereof |
| CN112262853A (en) * | 2020-10-21 | 2021-01-26 | 李永琴 | Preparation method of slightly acidic carbonic acid type hypochlorous acid water disinfectant |
| CN114796560A (en) * | 2021-05-26 | 2022-07-29 | 北京大学口腔医学院 | Method for sterilizing and drying oral impression |
| CN113907072A (en) * | 2021-09-09 | 2022-01-11 | 潍坊红阳药业有限公司 | Preparation method of high-precision weak acid hypochlorite disinfectant |
| CN114314514A (en) * | 2022-02-18 | 2022-04-12 | 华融化学股份有限公司 | Method for preparing hypochlorous acid from byproduct chlorine water |
| CN115282170A (en) * | 2022-08-11 | 2022-11-04 | 山东舒达生物科技有限公司 | Preparation method of powerful private lotion |
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