CN110339328A - Warming middle energizer to stop diarrhea emplastrum and the preparation method and application thereof for treating enteron aisle digestive disease - Google Patents
Warming middle energizer to stop diarrhea emplastrum and the preparation method and application thereof for treating enteron aisle digestive disease Download PDFInfo
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- CN110339328A CN110339328A CN201910650288.XA CN201910650288A CN110339328A CN 110339328 A CN110339328 A CN 110339328A CN 201910650288 A CN201910650288 A CN 201910650288A CN 110339328 A CN110339328 A CN 110339328A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7076—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising ingredients of undetermined constitution or reaction products thereof, e.g. rosin or other plant resins
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/26—Aristolochiaceae (Birthwort family), e.g. heartleaf
- A61K36/268—Asarum (wild ginger)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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Abstract
The invention discloses the warming middle energizer to stop diarrhea emplastrums and the preparation method and application thereof for treating enteron aisle digestive disease, Chinese medicine preparation includes folium artemisiae argyi, galangal, rhizoma zingiberis, stir-baked RHIZOMA CORYDALIS with vinegar, radix aucklandiae, Rhizoma Chuanxiong, radix aucklandiae, fructus amomi, evodia rutaecarpa, rhizoma atractylodis macrocephalae, HERBA ASARI from Liaoning of China, cortex cinnamomi, radix linderae, stir-baked RADIX PAEONIAE ALBA, radix glycyrrhizae preparata, and through polishing, screening, mixing, paste finally is made with honey, paste Chinese medicine is fabricated to antidiarrheal emplastrum again, it is applied with and uses, the present invention is combined with Chinese medicine with the external therapy of Chinese medicine, reach conditioning viscera, warm sun dispelling cold, warming middle energizer to stop diarrhea, adjust gastrointestinal function, treat chronic colitis, irritable bowel syndrome, functional dyspepsia FD.
Description
Technical field
The present invention relates to the field of Chinese medicines more particularly to a kind of warming middle energizer to stop diarrhea emplastrum for treating enteron aisle digestive disease and its
Preparation method and application.
Background technique
Chronic colitis, irritable bowel syndrome, functional dyspepsia FD are clinical common disease, frequently-occurring disease, have rising to become
Gesture.This kind of sickness influence people's lives quality, or even influence work, study and the basic living of patient, and this kind of disease
It is chronic disease, it is easy to recur, it is touching refractory.Such disease treatment time is long, takes drugs that the time is long, and patient compliance is poor.At present
In taking, two kinds of therapeutic schemes of Western medicine, but have the shortcomings that certain: Western medicine has certain side effect, and easy to recur；Chinese medicine
It takes and decocts medicine inconvenience, Chinese medicine poor taste, patient is difficult to adhere to treating.
Summary of the invention
In view of the above problems, the present invention is intended to provide it is a kind of for treating the warming middle energizer to stop diarrhea medicine of enteron aisle digestive disease
And the preparation method and application thereof, from the improvement to Antidiarrheal Chinese medicine ingredient, to preparation method and specific application, while in use
Medicine is combined with the external therapy of Chinese medicine, reaches conditioning viscera, temperature sun dispelling cold, and warming middle energizer to stop diarrhea adjusts gastrointestinal function, treats chronic
Colitis, irritable bowel syndrome, functional dyspepsia FD.
To achieve the goals above, the technical solution adopted in the present invention is as follows:
For treating the warming middle energizer to stop diarrhea emplastrum patch cream of pipe intestinal digesting disease, the antidiarrheal emplastrum includes according to parts by weight
Major ingredient:
15-25 parts of folium artemisiae argyi；
15-25 parts of galangal；
15-25 parts of rhizoma zingiberis；
10-15 parts of stir-baked RHIZOMA CORYDALIS with vinegar；
15-20 parts of radix aucklandiae；
15-20 parts of Rhizoma Chuanxiong；
15-20 parts of radix aucklandiae；
10-12 parts of fructus amomi；
10-12 parts of evodia rutaecarpa；
15-20 parts of rhizoma atractylodis macrocephalae；
6-8 parts of HERBA ASARI from Liaoning of China；
10-15 parts of cortex cinnamomi；
10-15 parts of radix linderae；
15-20 parts of stir-baked RADIX PAEONIAE ALBA；
6-10 parts of radix glycyrrhizae preparata；
Auxiliary material:
10-20 parts of basil oil；
10-20 parts of Laurocapram；
700-150 parts of propylene glycol；
150-250 parts of refined honey；
0010-20 parts of polyethylene glycol-8.
For treating the preparation method of the warming middle energizer to stop diarrhea medicine of pipe intestinal digesting disease, comprising the following steps:
S1 stock: folium artemisiae argyi, galangal, rhizoma zingiberis, stir-baked RHIZOMA CORYDALIS with vinegar, radix aucklandiae, Rhizoma Chuanxiong, radix aucklandiae, fructus amomi, evodia rutaecarpa, rhizoma atractylodis macrocephalae, the Liao Dynasty is thin
Pungent, cortex cinnamomi, radix linderae, stir-baked RADIX PAEONIAE ALBA, radix glycyrrhizae preparata weigh according to parts by weight, spare；
S2 is crushed: by above-mentioned 15 taste pulverizing medicinal materials at fine powder, and the medicinal powder through 100 meshes screening single-size, it mixes, it is standby
With；
S3 mixing: good fine powder screened in step S2 is put into batch mixer, in the case of stirring, sequentially adds cloves sieve
Strangle oil, Laurocapram, propylene glycol, refined honey, polyethylene glycol-8 00；S4 refined honey: honey is using preceding progress refined honey operation, removes
Portion of water, so that the moisture content in honey is in 5%-10%, and sterilizes, the honey viscosity of refined honey increases；
S5 prepares cream core: the medicinal material of honey and mixing in step S3 in step S4 through refined honey being mixed, and in mixing
Uniform stirring is completed in device, and cream core is made.
Preferably, the blender is arranged on turntable, turntable at the uniform velocity rotates mixing, the mixing by motor drive
Device is a ball grinder, and detachable feeder screen is arranged in the feed inlet of the ball grinder, and fixed material screen out is arranged in discharge port,
It is described it is fixed go out material screen on center position column is fixedly installed, multilayer setting up and down scrapes material strip on the column.
Preferably, the spiral inner wall that material strip is scraped described in every layer around the ball grinder is arranged one week, it is each described to scrape material strip
End and ball milling top tank structure flexible docking.
Preferably, the material strip of scraping is by scraping material head composition, institute made of stainless steel bent plate and flexible material
The end that scraper head is socketed in stainless steel bent plate is stated, several via holes is also provided in stainless steel bent plate side, is worn for material
It crosses.
Preferably, stainless steel bent plate end is integrally molded so as T-shaped structure, scraping material head includes solid part and hollow socket
Portion, hollow socket part are socketed in T-shaped structure, solid part be a conical head, ballhead or be used for tooth brush board and
The inner wall of ball grinder is in contact, and realizes the uniformly purpose of reconciliation and mixing.
For treating the application of the warming middle energizer to stop diarrhea emplastrum of pipe intestinal digesting disease, comprising the following steps:
S1 makes paste antidiarrheal emplastrum: by the ointment cream core for reconciling and mixing with honey and barrier sheet and hypo-allergenic adhesive plaster into
Row combines and produces antidiarrheal emplastrum；
S2 topical application of drug pre-treatment: Shenque or Guanyuan point are wiped into the position in warm water using clean towel before the topical application of drug；
The S3 topical application of drug: one time a day, 14-16g antidiarrheal emplastrum external application Shenque, Guanyuan point is taken continuously to treat 3-20 times every time；
S4 topical application of drug post-processing: the Chinese medicine that will be left on the skin after sticking is wiped with wet towel warm water.
Preferably, specific steps include: in the step S1
A stock: ointment is fabricated to the oval herbal cake with a thickness of 0.3-0.4cm by fixing mould, weight 14-16g should
A boss layer is also formed in oval herbal cake, and barrier sheet is sheared into growth 10-15cm, the square plate of wide 5-10cm, and in side
The four corners of shape piece cut into chamfering shape, are ready to be cut into and ellipse with barrier sheet hypo-allergenic adhesive plaster of the same size, center
Shape herbal cake opening of the same size, it is spare；
B, it makes: oval herbal cake is placed on to the center of barrier sheet, then one sealing ring of gluing on boss layer, seal
The size of circle and oval herbal cake are in the same size, are fixedly connected with ointment and barrier sheet flexibility with boss layer by sealing ring, most
Oval herbal cake and barrier sheet gluing are integrated by hypo-allergenic adhesive plaster afterwards, form antidiarrheal emplastrum.
Preferably, the fixing mould includes upper mold and lower mold, lower mold is fixedly installed, and upper mold passes through limit
Cylinder drive moves up and down, and is cut and is squeezed to ointment, several forming knife molds are arranged on upper mold, are provided on lower mold
Forming tank, the forming knife mold and forming tank, which match, produces oval medicine core.
Preferably, including cutting die body, stop collar, extrusion ring and cut ring, the cut ring on the forming knife mold
Be welded on cutting die body lower end, the height of cut ring is 3-4mm, and cut ring is hollow structure, extrusion ring along cut ring inner wall
Setting one circle, extrusion ring with a thickness of 1-2mm, stop collar is welded on the periphery of cutting die body, stop collar to cut ring bottom end
Vertical range 3-4mm.Emplastrum emplastrum
Spleen-stomach deficiency-cold irritable bowel syndrome (IBS) patient 48 is treated in 2016 to 2018 observation warming middle energizer to stop diarrhea emplastrums,
Clinical report is as follows:
1. general information
Choose 48 IBS to go to a doctor in one section of digestion, Shaanxi affiliated hospital, university of TCM in January, 2016 ~ 2018 year December
Patient is as research object, male 23, female 25；Age 18 ~ 65 years old, average (47.9 ± 3.5) year；The course of disease 0.6 ~ 7.0
Year, average (4.0 ± 1.4) year.Meet diagnostic criteria.
2. diagnostic criteria: referring to " new Chinese medicine guideline of clinical investigations " (tentative).
Spleen-stomach deficiency-cold irritable bowel syndrome patients
Cardinal symptom: 1. take place frequently after meal or early in the morning diarrhea, when it is half congealed when rushing down, be mingled with abdominal distension, indigestion；2. food intake is poor less；③
Early satiety, appetite stimulator or stomach discomfort, it is bored not relax；4. abdomen crymodynia；
(2) minor symptom: 1. happiness is warm by happiness, aggravates to the cold, and chance is warm to be mitigated, and borborygmus is endlessly；2. the tired weight of limbs, aversion to cold and preference for warmth, tired
Idle lazyness language, powerless or gas, four limbs are not warm less；3. soreness and weakness of waist and knees, very when crymodynia, sallow complexion；4. tongue nature is light, tongue fur is thin white, tongue body
There is indentation on fat big, side；5. deeptensepulse is thin and delicate.
3. treatment method:
It is treated with warming middle energizer to stop diarrhea emplastrum, one time a day, sticks 12 hours, stick acupuncture point: SHENQUE acupoint, Guanyuan point.
4. criterion of therapeutical effect and therapeutic effect
4.1 curative effect determinate standard
Effective: the clinical symptoms such as abdominal pain, diarrhea disappear substantially, and defecation returns to normal；It is effective: the clinical conditions such as abdominal pain, diarrhea
Shape makes moderate progress, and defecation frequency is reduced；Invalid: the clinical symptoms such as abdominal pain, diarrhea are not improved, and defecation frequency is not reduced.Face
Bed total effective rate=[(effective number of cases+effective number of cases)/total number of cases] × 100%.
4.2 treatment results
Effective 30 (62.5%) in 48 patients, effective 13 (27.08%), invalid 5 (10.42%), total effective rate is
89.58%。
The beneficial effects of the present invention are:
Firstly, it treats chronic gastrointestinal diseases, novelty: simply and easily therapy approach, the pair of no drug by external therapy
Effect and adverse reaction；
Secondly, the present invention is combined with Chinese medicine with the external therapy of Chinese medicine, reach conditioning viscera, temperature sun dispelling cold, warming middle energizer to stop diarrhea,
Gastrointestinal function is adjusted, chronic colitis, irritable bowel syndrome, functional dyspepsia FD are treated；
Again, antidiarrheal through the invention can be obviously improved the symptom of patient's diarrhea, abdominal distension, abdominal pain, simple and easy to do,
Patient is very easy to receive.
Detailed description of the invention
Fig. 1 is the front schematic view of anti-diarrheal plaster of the present invention.
Fig. 2 is the reverse side schematic diagram of anti-diarrheal plaster of the present invention.
Fig. 3 is the schematic diagram of mixer of the present invention.
Fig. 4 is the schematic diagram of fixing mould of the present invention.
Fig. 5 is the schematic diagram of the oval herbal cake of the present invention.
Wherein: 1- ball grinder, 2- feeder screen, 3- go out material screen, 4- ball-milling medium, 5- column, 6- stainless steel bent plate, 61-T shape
Structure, 7- scrape material head, the socket part 71-, 72- band tooth brush board, 8- via hole, 9- ellipse herbal cake, 91- boss layer, 10- upper mold,
Mold under 11-, 12- limiting cylinder, 13- molding die, 131- cutting die body, 132- stop collar, 133- cut ring, 134- are squeezed
Ring, 135- forming cavity, 14- forming tank.
Specific embodiment
In order to make those skilled in the art be better understood on technical solution of the present invention, with reference to the accompanying drawing and
Embodiment is further described technical solution of the present invention.
Embodiment:
For treating the warming middle energizer to stop diarrhea medicine of pipe intestinal digesting disease, the antidiarrheal agent includes according to parts by weight
Major ingredient:
15-25 parts of folium artemisiae argyi；
15-25 parts of galangal；
15-25 parts of rhizoma zingiberis；
10-15 parts of stir-baked RHIZOMA CORYDALIS with vinegar；
15-20 parts of radix aucklandiae；
15-20 parts of Rhizoma Chuanxiong；
15-20 parts of radix aucklandiae；
10-12 parts of fructus amomi；
10-12 parts of evodia rutaecarpa；
15-20 parts of rhizoma atractylodis macrocephalae；
6-8 parts of HERBA ASARI from Liaoning of China；
10-15 parts of cortex cinnamomi；
10-15 parts of radix linderae；
15-20 parts of stir-baked RADIX PAEONIAE ALBA；
6-10 parts of radix glycyrrhizae preparata；
Auxiliary material:
10-20 parts of basil oil；
10-20 parts of Laurocapram；
700-150 parts of propylene glycol；
150-250 parts of refined honey；
0010-20 parts of polyethylene glycol-8.
Folium artemisiae argyi, fructus amomi, evodia rutaecarpa, asarum, cortex cinnamomi, rhizoma zingiberis are added in side, plays key effect；1. these types of Drug
Temperature, returns spleen stomach meridian, Special medicine for special disease.2. they all have effects that warming spleen and stomach for dispelling cold antidiarrheal, they, which are combined together, plays mutual reinforcement between,
The effect to heighten the effect of a treatment.3. modern pharmacological research is found: they have volatile oil, there is warming spleen and stomach for dispelling cold, the pharmacology of antidiarrheal analgesic
Effect.
For treating the preparation method of the warming middle energizer to stop diarrhea medicine of pipe intestinal digesting disease, comprising the following steps:
S1 stock: folium artemisiae argyi, galangal, rhizoma zingiberis, stir-baked RHIZOMA CORYDALIS with vinegar, radix aucklandiae, Rhizoma Chuanxiong, radix aucklandiae, fructus amomi, evodia rutaecarpa, rhizoma atractylodis macrocephalae, the Liao Dynasty is thin
Pungent, cortex cinnamomi, radix linderae, stir-baked RADIX PAEONIAE ALBA, radix glycyrrhizae preparata weigh according to parts by weight, spare；
S2 is crushed: by above-mentioned 15 taste pulverizing medicinal materials at fine powder, and the medicinal powder through 100 meshes screening single-size, it mixes,
It is spare；
S3 mixing: good fine powder screened in step S2 is put into batch mixer, in the case of stirring, sequentially adds cloves
Basil, Laurocapram, propylene glycol, refined honey, polyethylene glycol-8 00；S4 refined honey: honey is using preceding progress refined honey operation, removes
Portion of water is gone, so that the moisture content in honey is in 5%-10%, and sterilizes, the honey viscosity of refined honey increases；Honey has emergency
Analgesic efficacy plays the role of adhesive.The ratio of honey and traditional Chinese medicine fine powder is: 3:7；
Above-mentioned auxiliary material and main ingredient ratio are 1:1, can just be made into the preparation of high quality in this way；
S5 prepares cream core: the medicinal material of honey and mixing in step S3 in step S4 through refined honey being mixed, and in mixing
Uniform stirring is completed in device, and cream core is made.
In order to improve the compounding effect of mixing step, and then the quality of production emplastrum is improved, therefore referring to shown in Fig. 3,
The blender is arranged on turntable, and turntable at the uniform velocity rotates mixing by motor drive, and the blender is a ball grinder 1, institute
The feed inlet for stating ball grinder 1 is arranged detachable feeder screen 2, discharge port setting it is fixed go out material screen 3, it is described it is fixed go out
Column 5 is fixedly installed in center position on material screen 3, and multilayer setting up and down scrapes material strip on the column 5；
Specifically, the spiral inner wall that material strip is scraped described in every layer around the ball grinder 1 is arranged one week, each end for scraping material strip
With 1 inner wall flexible docking of ball grinder；
Particularly, each described to scrape material strip and formed by scraping material head 7 made of stainless steel bent plate 6 and flexible material, it is described to scrape
Material head 7 is socketed in the end of stainless steel bent plate 6, is also provided with several via holes 8 in 6 side of stainless steel bent plate, wears for material
It crosses；
6 end of stainless steel bent plate is integrally molded so as T-shaped structure 61, scrapes material head 7 and includes solid part and hollow socket part 71, hollow
Socket part 71 be that sealing is socketed in T-shaped structure 61, solid part is a conical head, ballhead or to be used for tooth brush board 72
It is in contact with the inner wall of ball grinder 1, realizes the uniformly purpose of reconciliation and mixing.Particularly, the height of stainless steel bent plate 6 is 3-
5cm, with a thickness of 3-5mm, stainless steel bent plate 6 is arc panel, and the radian of arc panel can be set according to the structure of practical ball grinder 1
Meter, general radian are 10-20 degree；
Another embodiment is: scrape that material strip directlys adopt is the rod shape of flexible material integrated injection molding, and end is
Irregular protrusion swipe carries out mixing and scraper processing to material by flexible swing of swipe；
Specific operation process is: by honey and the medicinal powder of grinding while being poured into ball grinder 1 by feed inlet, while passing through charging
Sieve 2 carries out first of screening, starts the turntable of mixer bottom, turntable uniform rotation, and revolving speed is 300-1000 revs/min,
Revolving speed size is adjusted according to the actual needs, places ball-milling medium 4 in ball grinder 1, the use of ball-milling medium 4 is in the same of mixing
Shi Zaici achievees the purpose that ball milling, it might even be possible to achieve the purpose that nano ball grinding, can be made by the use of ball-milling medium 4 in this way
Medicinal powder and honey more fully mix, while mixed substance fine degree is higher；In actual mechanical milling process, in
The rotation of heart column 5 scrapes material strip by whipping, overlaps and contact with the inner wall of ball grinder 1, wipe off and be sticked in ball grinder 1
Slurry on wall, to guarantee that slurry is not wasted；Further, since the outfit of medicinal powder and honey is to be mixed according to a certain percentage
, when not complete ground and mixed, if a large amount of slurries are sticked on the inner wall of ball grinder 1, slurry in ball grinder 1 can be changed
Proportion influences ointment molding；Furthermore the slurry in ball grinder 1 can also be stirred during whipping by scraping material strip, make slurry
It mixes more uniform.Therefore, scrape material strip has double action in the ball grinder 1.
For treating the application of the warming middle energizer to stop diarrhea medicine of pipe intestinal digesting disease, comprising the following steps:
S1 makes paste anti-diarrheal plaster: the ointment for reconciling and mixing with honey and barrier sheet and hypo-allergenic adhesive plaster are combined
And produce anti-diarrheal plaster；Referring to Fig.1, shown in 2,
Particularly:
The structure of anti-diarrheal plaster is: ointment, barrier sheet, hypo-allergenic adhesive plaster.Medicinal powder and honey and the cake of press that sticks together, are made thickness with fixing mould
Spend 0.3cm, oval herbal cake 9, herbal cake is fixed in barrier sheet, after be attached on hypo-allergenic adhesive plaster；
A stock: ointment is fabricated to the oval herbal cake 9 with a thickness of 0.3cm, weight 15g, the ellipse by fixing mould
A boss layer 91 is also formed in herbal cake 9, and barrier sheet is sheared into growth 10-15cm, the square plate of wide 5-10cm, and in square plate
Four corners cut into chamfering shape, be ready to be cut into and oval medicine with barrier sheet hypo-allergenic adhesive plaster of the same size, center
The opening of the same size of cake 9, it is spare；
B, it makes: oval herbal cake 9 is placed on to the center of barrier sheet, then one sealing ring of gluing on boss layer 91, seal
The size of circle and oval herbal cake 9 are in the same size, are fixedly connected with ointment and barrier sheet flexibility with boss layer 91 by sealing ring,
Oval herbal cake 9 and barrier sheet gluing are integrated finally by hypo-allergenic adhesive plaster, form anti-diarrheal plaster；
Referring to shown in Fig. 4,5, further, in order to produce 9 structure of oval herbal cake of the present invention, therefore the present invention is directed to
Property devise dedicated fixing mould structure, the fixing mould includes upper mold 10 and lower mold 11, and lower mold 11 is fixed
Setting, upper mold 10 are moved up and down by the drive of limiting cylinder 12, are cut and squeezed to ointment, is arranged on upper mold 10
Several forming knife molds are provided with forming tank 14 on lower mold 11, and the forming knife mold and forming tank 14, which match, produces ellipse
Herbal cake 9 includes cutting die body 131, stop collar 132, extrusion ring 134 and cut ring 133, the cut ring on the forming knife mold
133 are welded on 131 lower end of cutting die body, and the height of cut ring 133 is 3mm, and cut ring 133 is hollow structure, and inside is forming cavity
135, cut ring 133 is cutting blade, and the oval herbal cake 9 of target size size is directly cut by the blade structure of annular
Structure, extrusion ring 134 along cut ring 133 one circle of inner wall setting, extrusion ring 134 with a thickness of 1.5mm, width 1.5mm,
The setting of extrusion ring 134 is to compress a part, shape downwards along with oval 9 periphery of herbal cake while limiting cylinder 12 pushes
At boss layer 91, stop collar 132 is welded on the periphery of cutting die body 131, stop collar 132 to 133 bottom end of cut ring it is vertical away from
From 3mm；
When operation, upper mold 10 drives the quickly movement downwards of molding die 13, with molding under the power effect of limiting cylinder 12
Slot 14 docks, while being limited by stop collar 132, carries out oval cutting to ointment by cut ring 133, passes through extruding
Ring 134 is pressed down against out one layer of boss layer 91, the thickness of the corresponding oval herbal cake 9 of the depth of forming tank 14；
S2 topical application of drug pre-treatment: Shenque or Guanyuan point are wiped into the position in warm water using clean towel before the topical application of drug；
The S3 topical application of drug: one time a day, 14-16g emplastrum external application Shenque, Guanyuan point emplastrum is taken continuously to treat 3-20 times every time；
A, it sticks when object is 2 years old or more children and adults, pregnant woman and big menstrual flow it is not recommended that patch；
B, during sticking, diet is preferably light, quit smoking, wine, raw food, greasy, pungent, seafood, product；Blower fan is avoided on the day of sticking
And it is stopped in the air-conditioned room of supercooling；
S4 topical application of drug post-processing
A, the Chinese medicine that will be left on the skin after sticking is wiped with wet towel warm water；
B, it sticks that rear local skin is micro- red or to have pigmentation, slight itching be normal reaction, does not affect the treatment.
C, stick rear local skin occur it is scratchy unbearably, scorching hot, sensation of pain when, ointment should be removed immediately, forbid scratching,
Drug should not be smeared without authorization, generally can voluntarily be fully recovered.
Typical case
1, patient Mr. Li, chronic colitis, abdominal distension, abdominal pain, soft stool are out of strength.Shenque is sticked with warming middle energizer to stop diarrhea emplastrum, is closed
After first cave is treated 3 times, upper disease is substantially reduced；After continuously treating 7 times with warming middle energizer to stop diarrhea emplastrum, upper disease disappears substantially.Stopped with middle benefit gas
It rushes down after emplastrum continuously treats 20 times, upper disease completely disappears.
2, patient Zhang, male, 35 years old.Abdominal distension, diarrhea March, are diagnosed as irritable bowel syndrome.It is sticked with warming middle energizer to stop diarrhea emplastrum
After Shenque, Guanyuan point are treated 1 time, upper disease mitigates；After continuously treating 14 times with warming middle energizer to stop diarrhea emplastrum again, symptom is completely disappeared.
3, patient Ma, female, 59 years old.Diarrhea, abdominal pain July, per rectum spectroscopy are shown: ulcerative colitis takes orally " beauty
Salad piperazine ", and with warming middle energizer to stop diarrhea emplastrum stick Shenque, Guanyuan point treat, one time a day after, treat 20 days, upper disease is substantially reduced；
Warming middle energizer to stop diarrhea emplastrum is deactivated, continues oral mesalazine treatment, after 3 months, symptom is completely disappeared.
4, patient congratulates certain, female, and 63 years old.Interruption diarrhea 20 years is aggravated with abdominal pain January, the dilute watery stool 5-6 of the daily diarrhea of patient
It is secondary, mucus is occasionally accompanied, with navel week abdominal pain, aggravates after food, subtracts bitterly after rushing down.Diagnosis are as follows: 1. irritable bowel syndrome 2. are chronic
Gastritis.It gives warming middle energizer to stop diarrhea emplastrum and sticks Shenque, Guanyuan point treatment, one time a day, after treatment 7 days, upper disease mitigates.It is further continued for
After stating treatment 20 days, symptom is completely disappeared.
5, patient Wu so-and-so, female, 65 years old.It aggravates 1 week in diarrhea March.Per rectum spectroscopy is shown: total colectomy no abnormality seen is examined
Break as " irritable bowel syndrome ".Give warming middle energizer to stop diarrhea emplastrum stick Shenque, Guanyuan point treatment, one time a day after, treat 2 days, upper disease
Mitigate；After re-treatment 7 days, symptom is completely disappeared.
6, patient Mr. Wang, female, 48 years old.Diarrhea, abdominal pain October, colonoscopy are shown: colitis, with warming middle energizer to stop diarrhea emplastrum
Shenque, Guanyuan point treatment are sticked, one time a day, dialectical oral traditional Chinese medicine decoction treatment is treated 20 days, upper disease is substantially reduced；Deactivate temperature
Middle antidiarrheal emplastrum, after continuing Chinese medicine treatment 1 month, symptom is completely disappeared.
The antidiarrheal emplastrum effect that the present invention makes: chronic colitis, irritable bowel syndrome, functional dyspepsia FD,
Card belongs to weakness of the spleen and the stomach and turbi damp obstructing in middle-JIAO person, demonstrate,proves and sees abdomen turgor, pain, diarrhea loose stool, and difference of receiving is out of strength etc..
The basic principles, main features and advantages of the present invention have been shown and described above.The technology of the industry
Personnel are it should be appreciated that the present invention is not limited to the above embodiments, and the above embodiments and description only describe this
The principle of invention, without departing from the spirit and scope of the present invention, various changes and improvements may be made to the invention, these changes
Change and improvement all fall within the protetion scope of the claimed invention.The claimed scope of the invention by appended claims and its
Equivalent thereof.
Claims (10)
1. the warming middle energizer to stop diarrhea emplastrum for treating pipe intestinal digesting disease, it is characterised in that: the antidiarrheal emplastrum is according to parts by weight
Number includes
Major ingredient:
15-25 parts of folium artemisiae argyi；
15-25 parts of galangal；
15-25 parts of rhizoma zingiberis；
10-15 parts of stir-baked RHIZOMA CORYDALIS with vinegar；
15-20 parts of radix aucklandiae；
15-20 parts of Rhizoma Chuanxiong；
15-20 parts of radix aucklandiae；
10-12 parts of fructus amomi；
10-12 parts of evodia rutaecarpa；
15-20 parts of rhizoma atractylodis macrocephalae；
6-8 parts of HERBA ASARI from Liaoning of China；
10-15 parts of cortex cinnamomi；
10-15 parts of radix linderae；
15-20 parts of stir-baked RADIX PAEONIAE ALBA；
6-10 parts of radix glycyrrhizae preparata；
Auxiliary material:
10-20 parts of basil oil；
10-20 parts of Laurocapram；
700-150 parts of propylene glycol；
150-250 parts of refined honey；
Polyethylene glycol-80010-20 parts.
2. as described in claim 1 for treating the preparation method of the warming middle energizer to stop diarrhea medicine of pipe intestinal digesting disease, feature exists
In, comprising the following steps:
S1 stock: folium artemisiae argyi, galangal, rhizoma zingiberis, stir-baked RHIZOMA CORYDALIS with vinegar, radix aucklandiae, Rhizoma Chuanxiong, radix aucklandiae, fructus amomi, evodia rutaecarpa, rhizoma atractylodis macrocephalae, the Liao Dynasty is thin
Pungent, cortex cinnamomi, radix linderae, stir-baked RADIX PAEONIAE ALBA, radix glycyrrhizae preparata weigh according to parts by weight, spare；
S2 is crushed: by above-mentioned 15 taste pulverizing medicinal materials at fine powder, and the medicinal powder through 100 meshes screening single-size, it mixes,
It is spare；
S3 mixing: good fine powder screened in step S2 is put into batch mixer, in the case of stirring, sequentially adds cloves
Basil, Laurocapram, propylene glycol, refined honey, polyethylene glycol-800；S4 refined honey: honey is using preceding progress refined honey operation, removes
Portion of water is gone, so that the moisture content in honey is in 5%-10%, and sterilizes, the honey viscosity of refined honey increases；
S5 prepares cream core: the medicinal material of honey and mixing in step S3 in step S4 through refined honey being mixed, and in mixing
Uniform stirring is completed in device, and cream core is made.
3. it is according to claim 2 for treating the preparation method of the warming middle energizer to stop diarrhea emplastrum of pipe intestinal digesting disease, it is special
Sign is that the blender is arranged on turntable, and turntable at the uniform velocity rotates mixing by motor drive, and the blender is a ball milling
Detachable feeder screen, the fixed material screen out of discharge port setting, described fixed is arranged in tank, the feed inlet of the ball grinder
Column is fixedly installed in center position on material screen out, and multilayer setting up and down scrapes material strip on the column.
4. according to claim 3 for treating the preparation method of the warming middle energizer to stop diarrhea medicine of pipe intestinal digesting disease, feature
It is, the spiral inner wall that material strip is scraped described in every layer around the ball grinder is arranged one week, each end and ball milling for scraping material strip
Top tank structure flexible docking.
5. it is according to claim 4 for treating the preparation method of the warming middle energizer to stop diarrhea emplastrum of pipe intestinal digesting disease, it is special
Sign is, each material strip of scraping is by scraping material head composition, the scraper headgear made of stainless steel bent plate and flexible material
It connects in the end of stainless steel bent plate, is also provided with several via holes in stainless steel bent plate side, is passed through for material.
6. according to claim 5 for treating the preparation method of the warming middle energizer to stop diarrhea medicine of pipe intestinal digesting disease, feature
It is, stainless steel bent plate end is integrally molded so as T-shaped structure, and scraping material head includes solid part and hollow socket part, hollow set
Socket part is socketed in T-shaped structure, and solid part is a conical head, ballhead or is used for tooth brush board and the inner wall of ball grinder
It is in contact, realizes the uniformly purpose of reconciliation and mixing.
7. the application of the warming middle energizer to stop diarrhea emplastrum for treating pipe intestinal digesting disease such as any one of claim 2-6 preparation,
It is characterized in that, comprising the following steps:
S1 makes paste antidiarrheal emplastrum: by the ointment cream core for reconciling and mixing with honey and barrier sheet and hypo-allergenic adhesive plaster
It is combined and produces antidiarrheal emplastrum；
S2 topical application of drug pre-treatment: Shenque or Guanyuan point are wiped into the position in warm water using clean towel before the topical application of drug；
The S3 topical application of drug: one time a day, 14-16g antidiarrheal emplastrum external application Shenque, Guanyuan point is taken continuously to treat 3-20 times every time；
S4 topical application of drug post-processing: the Chinese medicine that will be left on the skin after sticking is wiped with wet towel warm water.
8. according to claim 7 for treating the application of the warming middle energizer to stop diarrhea emplastrum of pipe intestinal digesting disease, feature exists
In specific steps include: in the step S1
A, it stocks up: ointment is fabricated to the oval herbal cake with a thickness of 0.3-0.4cm by fixing mould, weight 14-16g,
A boss layer is also formed in the ellipse herbal cake, by barrier sheet shear growth 10-15cm, the square plate of wide 5-10cm, and
The four corners of square plate cut into chamfering shape, be ready to barrier sheet hypo-allergenic adhesive plaster of the same size, center be cut into it is ellipse
Round herbal cake opening of the same size, it is spare；
B, it makes: oval herbal cake is placed on to the center of barrier sheet, then one sealing ring of gluing on boss layer, sealing ring
Size and oval herbal cake are in the same size, are fixedly connected with ointment and barrier sheet flexibility with boss layer by sealing ring, finally lead to
It crosses hypo-allergenic adhesive plaster to be integrated oval herbal cake and barrier sheet gluing, forms antidiarrheal emplastrum.
9. according to claim 8 for treating the application of the warming middle energizer to stop diarrhea medicine of pipe intestinal digesting disease, which is characterized in that
The fixing mould includes upper mold and lower mold, and lower mold is fixedly installed, and upper mold is moved up and down by limiting cylinder drive,
Ointment is cut and is squeezed, several forming knife molds are arranged on upper mold, forming tank, the forming cutter are provided on lower mold
Mould and forming tank, which match, produces oval medicine core.
10. according to claim 9 for treating the application of the warming middle energizer to stop diarrhea emplastrum of pipe intestinal digesting disease, feature exists
In including cutting die body, stop collar, extrusion ring and cut ring on the forming knife mold, the cut ring is welded under cutting die body
End, the height of cut ring are 3-4mm, and cut ring is hollow structure, inner wall setting one circle of the extrusion ring along cut ring, extrusion ring
With a thickness of 1-2mm, stop collar is welded on the periphery of cutting die body, the vertical range 3-4mm of stop collar to cut ring bottom end.
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| Title |
|---|
| 丁东翔等: "肠易激综合征( 腹泻型) 脾胃虚寒证患者的膏方治疗初探-320 例临床对照分析", 《海峡药学》 * |
| 王捷虹等: "排便灵治疗便秘型肠易激综合征48例", 《陕西中医》 * |
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