CN110339249A - A kind of Chinese medicine composition and its preparation method and application for hemorrhoid anal fissure - Google Patents
A kind of Chinese medicine composition and its preparation method and application for hemorrhoid anal fissure Download PDFInfo
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- CN110339249A CN110339249A CN201910750965.5A CN201910750965A CN110339249A CN 110339249 A CN110339249 A CN 110339249A CN 201910750965 A CN201910750965 A CN 201910750965A CN 110339249 A CN110339249 A CN 110339249A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/739—Sanguisorba (burnet)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0031—Rectum, anus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
Abstract
The Chinese medicine composition and its preparation method and application that the invention discloses a kind of for hemorrhoid anal fissure is to solve the problems in the treatment and prevention of existing hemorrhoid anal fissure.The present invention includes the raw material of following parts by weight: 5-10 parts of honeysuckle, 3-8 parts of eclipta, 2-6 parts of sophora flower, 2-6 parts of garden burnet, 0.5-1 parts of peppermint, 10-15 parts of surfactant, 0.3-0.75 parts of amino acid, 0.4-0.6 parts of 1-2 propylene glycol and 0.35-0.7 parts of tea oil.This product raw material sources are extensive, and the finished product of preparation has clearing heat and detoxicating, swelling and pain relieving, bacterio static itching-relieving, and cooling blood and hemostasis holds back the effect of solid anti-avulsion and moist anticracking, can be used for preventing and treating internal piles, external piles, mixed hemorrhoid and anal fissure；The dosage form multiplicity of this product, is all made of nontoxic Chinese medicine material, does not have toxic side effect to child and pregnant woman, and lotion, which is made, can be used for the cleaning of children's anal fissure hemorrhoid, can carry out stoste cleaning, directly effect affected part.
Description
Technical field
The present invention relates to hemorrhoid anal fissure therapy field, specifically a kind of Chinese medicine composition for hemorrhoid anal fissure.
Background technique
Hemorrhoid anal fissure is a kind of common disease positioned at anus area, and any age can all fall ill, but with age,
Disease incidence gradually increases.In China, hemorrhoid are the most common anorectal diseases, are known as " ten male nine hemorrhoid ", the saying of " ten female, ten hemorrhoid ".
There is investigation to show, the disease incidence of China women is 67%, and the disease incidence of male is 53.9%.The disease incidence of women be higher than male with
The distinctive physilogical characteristics of women are related, and the perianal of women influences whether introitus, cause unnecessary gynaecological imflammation
Infection.Especially in the menstrual period, the gestational period, puerperium is easier to cause the generation of hemorrhoid, and quality of life seriously reduces.
The cause of disease about hemorrhoid is there are mainly two types of theory.It is varicose vein theory first, it is believed that hemorrhoid are under distal rectal mucous membrane
Venous mass is formed by with veniplex extravasated blood, expansion and the buckling under anal canal skin.However well accepted theory is at present
The anal cushions down theory of Thomson, it is believed that hemorrhoid are originally the normal anatomical structure in anal canal position, i.e. blood vessel pad, be dentate line and
The cyclic annular cavernous transformation taeniae telarum of the above 1.5cm.When only anus pad tissue is abnormal and is associated with symptom, hemorrhoid could be known as,
It just needs to treat, therapeutic purposes are releasing symptoms, and non-elimination hemorrhoid body.There are many risk factor of hemorrhoid, wherein constipation, long-term drink
It is main inducing that wine, a large amount of irritable foods of feed and sitting are stood long.Hemorrhoid are divided into internal piles by the difference of happening part, external piles, mix
Close hemorrhoid.Clinical manifestation is main are as follows: 1. are mainly shown as hematochezia, and the property of hematochezia can be painless, intermittent, blood after an action of the bowels, just when
Bleed or toilet paper on band blood, constipation drinks or aggravates after feeding irritable food.2. the only falling inflation sense of pure internal piles without pain,
Can bleeding, be developed to prolapsus, pain just occur when merging thrombosis, incarceration, infection.3. internal piles is divided into 4 degree.1. I degree of defecation
When bleeding, bleeding can voluntarily stop after an action of the bowels, and hemorrhoid do not deviate from anus；2. II degree often has hematochezia；Deviate from anus when defecation, after defecation from
It is dynamic also to receive；3. needing Hand supplementary also to receive after III degree of hemorrhoid abjection；IV degree of hemorrhoid outside anus, cannot also be received for a long time；Wherein, II degree or more
At mixed hemorrhoid, the symptom for showing as internal piles and external piles exists simultaneously internal piles multiform, may occur in which pain discomfort, itch, wherein itch
Often due to toughness secretion outflow when hemorrhoid are deviate from.Afterwards at mixed hemorrhoid more than three degree.4. usually without characteristic symptom, thrombus occurs for external piles
And inflammation Shi Keyou swelling, pain.
Anal fissure, mainly anal canal are split, and the disease incidence of anal fissure accounts for about the 20% of anal intestine disease, mostly based on young man, but anus
Split more favor women, especially young woman.China's women disease incidence is approximately 1.8 times of male, Japanese large intestine anus magazine report
Accuse the result is that 1.6 times.Anal fissure can be divided into for three phases according to state of an illness weight, 1. I phase anal fissure: also referred to as initial anal fissure, i.e., fresh anus
It splits or early stage anal fissure.Anal canal skin table shallowly damages, and wound surrounding tissue is normal.2. II phase anal fissure: also referred to as simple anal fissure.Anus
Pipe has formed exedens breach, but without complication, no hypertrophy of anal papilla, sentry's hemorrhoid and subcutaneous fistula etc..3. III phase anal fissure: referring to
Old anal, breach are in oldness ulcer, merge hypertrophy of anal papilla and sentry's hemorrhoid, or with subcutaneous fistula and anal cryptitis disease
Deng.
Treatment hemorrhoid are broadly divided into above several at present: 1, it is asymptomatic without treatment；2, topical therapy, with paste,
Suppository, lotion, dipping；3, local injection therapy；4, plastic loop ligation；5, physical therapy, such as laser, cold therapy；6, operation is treated
Method.It is not required to treatment firstly, asymptomatic and is not consistent with Chinese medicine viewpoint of " preventiveing treatment of disease "；Secondly, traditional local application, after must cleaning
Medication is treated again, but anal canal is difficult to clean, and anal canal crissum gauffer is more, therefore uses conventional medication after clear water cleaning, is treated
It imitates bad.Third, since compatriots' habituation wipes crissum with toilet paper after an action of the bowels, just just stain is more for slag at crissum anal canal, often stores
In crissum anal canal fold place, bacterium easy to breed, therefore it is liable to illness, and cause traditional therapy unsatisfactory curative effect.
It is main to be treated using the drug for treating hemorrhoid or operation at present for the treatment of anal fissure, however, many people are not
The indication for reaching operation thinks that the patient of conservative therapy suffers from no medicine again and can be used, and patient lives in extremely frightened and pain daily
In, people are also in the research for carrying out related fields.
Summary of the invention
The embodiment of the present invention is designed to provide a kind of Chinese medicine composition for hemorrhoid anal fissure, to solve above-mentioned background
The problem of being proposed in technology.
To achieve the above object, the embodiment of the present invention provides the following technical solutions:
A kind of Chinese medicine composition for hemorrhoid anal fissure, the raw material including following parts by weight: 5-10 parts of honeysuckle, eclipta
3-8 parts, 2-6 parts of sophora flower, 2-6 parts of garden burnet, 0.5-1 parts of peppermint, 10-15 parts of surfactant, 0.3-0.75 parts of amino acid, 1-2
0.4-0.6 parts and tea oil 0.35-0.7 parts of propylene glycol.
As further embodiment of the embodiment of the present invention: the Chinese medicine composition for hemorrhoid anal fissure, including it is following heavy
Measure the raw material of part: 6-9 parts of honeysuckle, 4-7 parts of eclipta, 3-6 parts of sophora flower, 3-6 parts of garden burnet, 0.7-1.1 parts of peppermint, surface-active
10-15 parts of agent, 0.38-0.75 parts of amino acid, 0.46-0.6 parts of 1-2 propylene glycol and 0.42-0.7 parts of tea oil.
The preparation method of the Chinese medicine composition for hemorrhoid anal fissure, the specific steps are as follows:
Eclipta, honeysuckle, sophora flower, garden burnet and peppermint are ground into powder by step 1, obtain smashed eclipta,
Honeysuckle, sophora flower, garden burnet and peppermint；
Smashed eclipta, honeysuckle, sophora flower and garden burnet are added to the water immersion 25-40 minutes, are heated to by step 2
92-95 DEG C and decoction 0.8-1.4 hour is stirred, the 4-8 minutes smashed peppermints of addition before decoction terminates, then be centrifuged,
Filtering, merging filtrate and is condensed into thick paste at squeezing；
Thick paste is added to the water and is stirred evenly, obtains solution by step 3；
Step 4, by surfactant, amino acid, 1-2 propylene glycol and tea oil is added to the water and homogenization, then plus
Enter solution, finally with newborn acid for adjusting pH value, different preparations is obtained using corresponding technique.
As further embodiment of the embodiment of the present invention: the partial size of powder is 0.4-0.6cm in step 1.
As further embodiment of the embodiment of the present invention: it further include that thick paste is dried in vacuo and is crushed in step 2,
The first mixture is obtained, the first mixture is added to the water and is stirred evenly in step 3 at this time.
As further embodiment of the embodiment of the present invention: preparation includes lotion, coagulates after different auxiliary materials is added in step 4
Any one in glue, capsule, tablet, suppository, paste and powder.
The invention also includes the Chinese medicine compositions for hemorrhoid anal fissure to prepare the medicine for preventing and treating hemorrhoid, anal fissure
Application in object.
The Chinese medicine composition for hemorrhoid anal fissure is directly clear preventing and treating the cleaning method in hemorrhoid anal fissure
Anal canal skin is washed, i.e. cleaning anal canal realization is washed and controlled while carrying out, before without such method, existing some traditional Chinese medicine lotions
Crissum surface can only be cleaned, is cleaned not into anal canal, unsatisfactory curative effect.
This product is added in several tastes for treatment on the basis of using security level relatively high surfactant
Medicine adjusts the pH value of suitable human skin.Accomplish that prevention and treatment is had both, clean at any time, cleans into anal canal, be easy to use, it is such direct
Anal canal crissum is cleaned to improve the preparation and method of hemorrhoid anal fissure, has no record in the literature.For internal piles, mixed hemorrhoid is bad to be given
Medicine patient, can wear fingerstall cleaning and syringe administration, and crissum raffinate cleans in time.For postoperative patient, should also accomplish through
Often cleaning, prevents from recurring.Be directed to the special circumstances and physilogical characteristics of women, this product due to used Chinese medicine and auxiliary material,
It is the bulk pharmaceutical chemicals having no toxic side effect, pregnant woman will not be also damaged, guarantees pregnancy period safety, therefore be also suitble to women in the pregnancy period
It uses.It due to the immature particularity of children's crissum, can not perform the operation, the more children of drug are not available, therefore clean conduct
The optimal treatment mode of children treats and prevents hemorrhoid, the method for anal fissure is to use the direct hand of lotion when preparation is lotion
It washes, wear fingerstall cleaning or syringe administration affected part, lotion or raffinate are directly washed off after three to five minutes, it is convenient to use.
Compared with prior art, the beneficial effect of the embodiment of the present invention is:
This product raw material sources are extensive, and by the cooperation of various raw materials, the finished product of preparation has clearing heat and detoxicating, and detumescence stops
Bitterly, the effect of solid anti-avulsion and moist anticracking is held back in bacterio static itching-relieving, cooling blood and hemostasis, can be used for preventing and treating internal piles, external piles, mixing
Hemorrhoid and anal fissure, are preferred for treatment and do not reach the hemorrhoid patients of Surgery operation indication and prevention having the patients of oldness hemorrhoid, only
Cleaning is just treated, and particularly with the patient of female's surname pregnancy period hemorrhoid anal fissure and children's anal fissure hemorrhoid, has filled up female's surname pregnancy period
Can not medication children without the available blank of medicine, the effect that can play prevention hemorrhoid anal fissure is used for a long time；
The dosage form multiplicity of this product, is all made of nontoxic Chinese medicine material, does not have toxic side effect to child, lotion institute is made
It is that washing of children product often uses raw material or edible raw material with auxiliary material, child is not injured, can be used for children's anal fissure hemorrhoid
Cleaning, stoste cleaning can be carried out, directly effect affected part, quick acting is easy to use.
Specific embodiment
The technical solution of the patent is explained in further detail With reference to embodiment.
Embodiment 1
A kind of Chinese medicine composition for hemorrhoid anal fissure, including honeysuckle 50g, eclipta 30g, sophora flower 20g, garden burnet 20g,
Peppermint 0.6g, cocounut oil acyl hydroxysultaine 150g, cocounut oil acyl both sexes base diethyl acid disodium 150g, amino acid N MF-50 guarantor
Humectant 5g, 1-2 propylene glycol 5g, sodium chloride 9g, tea oil 5g, water 1386g.
The preparation method comprises the following steps:
(1) raw material honeysuckle 50g, eclipta 30g, sophora flower 20g, garden burnet 40g, peppermint 6g are taken, be ground into 0.5CM size with
It is spare；
(2) the above-mentioned raw material 140g crushed in addition to peppermint is taken, is added in 1000g water and impregnates 30 minutes, be heated to 95 DEG C
Left and right, stirring decoct 1 hour, the peppermint 6g crushed are added within last 5 minutes.300 mesh are crossed to be centrifuged, filtered, squeezed, merged again
Filtrate, the 200g being condensed into are spare；
(3) by cocounut oil acyl hydroxysultaine 150g, cocounut oil acyl both sexes base diethyl acid disodium 150g, water 250g investment
In 40 DEG C of Homogenized emulsifiers, amino acid N MF-50 moisturizer 5g, 1-2 propylene glycol 5g is added after stirring 30 minutes and continues stirring 30
The matrix liquid that minute is formed is with spare；
(4) concentrated traditional Chinese medicine investment is had in the blender of matrix liquid, is kept for 35 DEG C, stirring emulsifying 30 minutes, uses chlorine
Change sodium 9g to add in 236g water, adds tea oil 5g, it is common to put into blender, it stirs 30 minutes, lotion 1000g is made.Finally use
Lactic acid reconciles lotion pH value to 6；
(5) stand 12 hours after it is canned enter closed container.
Embodiment 2
A kind of Chinese medicine composition for hemorrhoid anal fissure, including honeysuckle 70g, eclipta 40g, sophora flower 30g, garden burnet 30g,
Peppermint 7g, cocounut oil acyl hydroxysultaine 150g, cocounut oil acyl both sexes base diethyl acid disodium 150g, amino acid N MF-50 moisturizing
Agent 5g, 1-2 propylene glycol 5g, sodium chloride 9g, tea oil 5g, water 1386g.
The preparation method comprises the following steps:
(1) raw material honeysuckle 70g, eclipta 40g, sophora flower 30g, garden burnet 30g, peppermint 7g are taken, be ground into 0.5CM size with
It is spare；
(2) the above-mentioned raw material 170g crushed in addition to peppermint is taken, is added in 1000g water and impregnates 30 minutes, be heated to 95 DEG C
Left and right, stirring decoct 1 hour, the peppermint 7g crushed are added within last 5 minutes.300 mesh are crossed to be centrifuged, filtered, squeezed, merged again
Filtrate, the 200g being condensed into are spare；
(3) by cocounut oil acyl hydroxysultaine 150g, cocounut oil acyl both sexes base diethyl acid disodium 150g, water 250g investment
In 40 DEG C of Homogenized emulsifiers, amino acid N MF-50 moisturizer 5g, 1-2 propylene glycol 5g is added after stirring 30 minutes and continues stirring 30
The matrix liquid that minute is formed is with spare；
(4) concentrated traditional Chinese medicine investment is had in the blender of matrix liquid, is kept for 35 DEG C, stirring emulsifying 30 minutes, uses chlorine
Change sodium 9g to add in 236g water, adds tea oil 5g, it is common to put into blender, it stirs 30 minutes, lotion 1000g is made.Finally use
Lactic acid reconciles lotion pH value to 6；
(5) stand 12 hours after it is canned enter closed container.
Embodiment 3
A kind of Chinese medicine composition for hemorrhoid anal fissure, including honeysuckle 80g, eclipta 50g, sophora flower 40g, garden burnet 40g,
Peppermint 8g, cocounut oil acyl hydroxysultaine 150g, cocounut oil acyl both sexes base diethyl acid disodium 150g, amino acid N MF-50 moisturizing
Agent 5g, 1-2 propylene glycol 5g, sodium chloride 9g, tea oil 5g, water 1386g.
The preparation method comprises the following steps:
(1) raw material honeysuckle 80g, eclipta 60g, sophora flower 40g, garden burnet 40g, peppermint 8g are taken, be ground into 0.5CM size with
It is spare；
(2) the above-mentioned raw material 220g crushed in addition to peppermint is taken, is added in 1000g water and impregnates 30 minutes, be heated to 95 DEG C
Left and right, stirring decoct 1 hour, the peppermint 8g crushed are added within last 5 minutes.300 mesh are crossed to be centrifuged, filtered, squeezed, merged again
Filtrate, the 200g being condensed into are spare；
(3) by cocounut oil acyl hydroxysultaine 150g, cocounut oil acyl both sexes base diethyl acid disodium 150g, water 250g investment
In 40 DEG C of Homogenized emulsifiers, amino acid N MF-50 moisturizer 5g, 1-2 propylene glycol 5g is added after stirring 30 minutes and continues stirring 30
The matrix liquid that minute is formed is with spare；
(4) concentrated traditional Chinese medicine investment is had in the blender of matrix liquid, is kept for 35 DEG C, stirring emulsifying 30 minutes, uses chlorine
Change sodium 9g to add in 236g water, adds tea oil 5g, it is common to put into blender, it stirs 30 minutes, lotion 1000g is made.Finally use
Lactic acid reconciles lotion pH value to 6；
(5) stand 12 hours after it is canned enter closed container.
Embodiment 4
A kind of Chinese medicine composition for hemorrhoid anal fissure, including honeysuckle 100g, eclipta 80g, 60g parts of sophora flower, garden burnet
60g, peppermint 12g, cocounut oil acyl hydroxysultaine 150g, cocounut oil acyl both sexes base diethyl acid disodium 150g, amino acid N MF-
50 moisturizer 5g, 1-2 propylene glycol 5g, sodium chloride 9g, tea oil 5g, water 1386g.
The preparation method comprises the following steps:
(1) raw material honeysuckle 100g, eclipta 80g, sophora flower 60g, garden burnet 60g, peppermint 12g is taken to be ground into 0.5CM size
With spare；
(2) the above-mentioned raw material 300g crushed in addition to peppermint is taken, is added in 1000g water and impregnates 30 minutes, be heated to 95 DEG C
Left and right, stirring decoct 1 hour, the peppermint 12g crushed are added within last 5 minutes.300 mesh are crossed to be centrifuged, filtered, squeezed, closed again
And filtrate, the 200g that is condensed into are spare；
(3) by cocounut oil acyl hydroxysultaine 150g, cocounut oil acyl both sexes base diethyl acid disodium 150g, water 250g investment
In 40 DEG C of Homogenized emulsifiers, amino acid N MF-50 moisturizer 5g, 1-2 propylene glycol 5g is added after stirring 30 minutes and continues stirring 30
The matrix liquid that minute is formed is with spare；
(4) concentrated traditional Chinese medicine investment is had in the blender of matrix liquid, is kept for 35 DEG C, stirring emulsifying 30 minutes, uses chlorine
Change sodium 9g to add in 236g water, adds tea oil 5g, it is common to put into blender, it stirs 30 minutes, lotion 1000g is made, finally uses
Lactic acid reconciles lotion pH value to 6；
(5) stand 12 hours after it is canned enter closed container.
Compliance test result is carried out to the preparation of embodiment 1, verification method is as follows: volunteer is included in standard: with different degrees of
The patient of hemorrhoid anal fissure, the chief complaint of hemorrhoid mainly have pain, itch, bleeding, the enlargement of meat ball, abjection.Anal fissure patient is main
With the malaise symptoms person such as breach, bleeding, pain, regardless of sex, the age is as study subject.
Application method: it when after an action of the bowels or having a bath, after cleaning crissum with warm water, squeezes out stoste 2-4 drop coating and smears crissum and rub bubble
Foam keeps foam in crissum, can wear on the inside of fingerstall cleaning crissum, crissum foam and wiped clean are rinsed after five minutes.It is early daily
Evening respectively washes once, after an action of the bowels plus washes primary.
Observation index: hemorrhoid observe cardinal symptom: pain, itch, bleeding, the enlargement of meat ball, abjection, foreign body sensation；Anal fissure is seen
Examine cardinal symptom: breach, bleeding, pain.Observe the 7th day, patient symptom improvement situation on the 21st.
Effect criterion: effective: chief complaint disappearance or substantially reduced；Effective: chief complaint mitigates；It is invalid: main suit
Symptom and sign is without significant change.
The 7th day cardinal symptom of patient improves situation and is shown in Table 1.
Table 1
The 21st day cardinal symptom of patient improves situation and is shown in Table 2.
Table 2
As can be seen from Table 1 and Table 2, the product of embodiment 1 has apparent effect to hemorrhoid anal fissure, when with using
Between extension, the improvement rate of cardinal symptom significantly improves.
Typical case:
1, square XX, male, people from Huairou District, Beijing City, mixed hemorrhoid second phase 5 years, often just when bleeding, the suppository opened with hospital,
Smoke lotion, paste, the civil various treatments of folk prescription, not very good effect are rear to go out again with stopping blooding after product 7 days of embodiment 1
Cross a blood, then with stopping blooding after 5 days, hemorrhoid meat ball reduces 2/3rds.Self is felt quite pleased, and washes 3 times weekly always later and comes
Maintenance, without bleeding again, hemorrhoid are not also recommitted.
2, Cai X, male, Shanxi Province Xinzhou City people, with mild stenosis, early application MAYINGLONGZHICHUANGGAO is red mould within anal fissure 6 months
Plain ointment, too peaceful cream treatment, breach can not heal always, also cause the expansion about slight spasm of flesh, use the product 10 of embodiment 2
After it, breach healing, after continue to be assisted after expanding anus 6 months with washing lotion without anal fissure mistake again.
3, king X, male, Hubei people from Wuhan, children 3 months 1 years old, child was often just dry crude hard, and anal fissure sprays blood, has hemorrhoid, sees
Wuhan Ji Jia hospital can not treat in addition to the probiotics with soft stool, and child often cries and screams, since breach is deeper, with implementation
Heal behind product 15 days of example 4, after consolidate 3 months, because thick just split again after half a year, with healing after product 7 days of embodiment 4,
Consolidate again 2 months.It does not commit excesses again later.
4, high X, female, people from Langfang in Hebei Province, inflammatory external hemorrhoid are directed at crissum pain, the pain after instructing using erythromycin ointment
Mitigating, but crissum surprise is itched incomparably, patient is difficult to endure, and it is many with releiving at once after the product of embodiment 3, with one week pain itch
Disappear, hemorrhoid atrophy to original a quarter size, after once in a while discomfort just wash at once, what is maintained always is fine, and hemorrhoid do not become again
Greatly.
5, Min XX, female, people from Senior Residents in Fengxian District of Shanghai, five years ago were performed the operation, recurrence, three phase mixed hemorrhoids.It is required when Zai Qu hospital
Continue to perform the operation, the pain because fearing operation resolutely refuses to perform the operation, and selects conservative therapy, is reduced with 7 days hemorrhoid after the product of embodiment 2
To original half, original a quarter is narrowed down to after 14 days, there was only original 1/10th after 25 days, later weekly
Cleaning three times, is not recurred again.
6, king XX, female, Shandong Weifang people from Hanting District, postpartum anal fissure patient lead to constipation since postpartum activity is reduced,
Cause anal fissure, the post-natal depression that patient generates.It is just alleviated using the product same day pain of embodiment 1, is obviously subtracted after 3 days
Gently, breach healing in 7 days.Patient heart might as well be very much.It due to not consolidating, commits excesses once after 2 months, consolidates after healing in 7 days again
Consolidate 3 months, never recommit the moon.
7, high XX, female, three phase of pregnancy period mixed hemorrhoid, pain is with bleeding.It can only be improved to hospital using some probiotics greatly
Just situation, because in the pregnancy period, doctor's also not very good method since washing lotion is external application, and is rinsed, referring physician after three minutes
Afterwards, saying can be used, and patient is disappeared using pain after product 7 days of embodiment 4, and bleeding disappears, because worrying to recommit, protect always
The pregnancy period is held to wash daily once.Mixed hemorrhoid is down to the second phase, remains fine always.
8, Qiu XX, male, Wanzhou prefecture of Chongqing people drink white wine because previous evening eats barbecue, lead to hemorrhoid acute attack, patient's readme
Cannot leave the bed walking, can only take off in bed, and pharmacy has bought MAYINGLONGZHICHUANGGAO and do not mitigated, and use product 2 days of embodiment 3
Afterwards, pain relief can walk with descending, and after 7 days, hemorrhoid ball disappears, and has consolidated two weeks, rear never to recur.It has formed
The good habit cleaned weekly.
9, old XX, male, Luoyang, henan people from Jianxi District, slight hemorrhoid cause constipation to cause anal fissure with anal fissure patient because staying up late,
Originally the silver ion gel for the treatment of hemorrhoid, chitosan gel rubber are used, erythromycin ophthalmic ointment in vain then abandons conservative therapy standard
Standby operation, feels that oneself still cannot perform the operation for preoperative 30 minutes, then starts the product with embodiment 2, pain obviously subtracts after 3 days
Gently, after 7 days without pain, breach heals at 10 days, accepts suggestion and has consolidated 3 months, anal fissure did not occur again.
10, hair XX, female, Shaanxi Xi'an people from Changan District, for the second stage of mixed hemorrhoid with bleeding, anal fissure has sentry's hemorrhoid, while having anal sinus
Inflammation, oral traditional Chinese medicine before, the too peaceful bolt of external application, MAYINGLONGZHICHUANGGAO, the state of an illness does not improve, after the product using embodiment 2, hemorrhoid
It is reduced to a phase, heals within anal fissure 7 days, without going out blood again, while suggesting that she takes Berberine hydrochloride and probiotics, anal sinusitis causes
Symptom also disappear.
Working principle of the invention is as follows:
Honeysuckle has removing miliaria and relieving itching, clearing heat and detoxicating, antibacterial, anti-acne, anti-inflammatory and other effects, cures mainly warm disease heating, heat toxin
Bloody flux, ulcer serious case of furuncle etc..Modern study proves that honeysuckle contains the pharmacological components such as chlorogenic acid, cyanidenon glycosides, to haemolysis
The various pathogens and infection of the upper respiratory tract Causative virus etc. such as property streptococcus, Staphylococcus aureus have stronger restraint, in addition
It can also strengthen immunity.
Eclipta has cooling blood and hemostasis, the effect of benefiting yin kidney tonifying.Tang Materia Medica: main bloody flux.Acupuncture sore hair, big vast blood can not stop
Person applies it；Juice Tu Famei, it is raw fast and numerous." Japan hanako materia medica ": small intestine is led in apocenosis, hemostasis, applies all sores and silkworm Guo." the southern regions of the Yunnan Province sheet
Grass ": permanent tooth, crow palpus wash nine kinds of hemorrhoid." sward pharmacological property is standby to be wanted ": bruise wound is controlled, wine top is managed, Ci is killed in resolving sputum, antipruritic, solid carbon dioxide.
" classification is herbal ": hemostasis, kidney tonifying are annealed, and detumescence is controlled leaching, collapsed.
Sophora flower bitter, it is mild-natured, it is nontoxic, have effects that heat-clearing, cool blood, hemostasis, decompression.Sophora flower is used as treatment hematochezia more
Common medicine, for spitting blood caused by hemorrhoid hemorrhage caused by large intestinal damp-heat, hematochezia, bloody flux and blood-head, bleeding from five sense organs or subcutaneous tissue." collected statements on the herbal foundation ":
Sophora flower (micro- stir-fry) three money, two money of white peony (stir-fry), Fructus Aurantii (bran stir-fry) money.Radix Glycyrrhizae five is divided.It is decocted in water for oral dose." rare treasure side in small suitcase ": Chinese scholartree
Flower (stir-fry), each one liang of Radix Curcumae (stewing).For end.It is every to take two money, under light fermented soya beans, salted or other wise soup." the southern regions of the Yunnan Province book on Chinese herbal medicine ": sophora flower was burnt, releasing fire-toxin, and pestle is
End.Every to take a money, watery wine is sent down." experience good recipe ": Huaihua San, sophora flower (half two fries, and half two is raw), one liang of fructus gardeniae (peeling,
It fries).Upper is last.It is every to take two money, newly draw water under tune." Empirical formula ": sophora flower, ching-chieh equal part.For end, wine takes a money an ancient type of spoon.
Garden burnet is cold in nature, bitter acid, nontoxic；Return liver, lung, kidney and large intestine channel.There is cooling blood and hemostasis, clearing heat and detoxicating, culturing purity and nourishing-yin,
Healing up sore and subduing swelling and other effects.Garden burnet root is used as medicine, cold nature, bitter.Modern medicine study proves: garden burnet has blood-stanching and blood-cooling, heat-clearing
Removing toxic substances, astringing to arrest diarrhea and the effect for inhibiting a variety of pathogenic microorganisms and tumour, can treat haematemesis, bloody flux, burn wound, eczema, on
The diseases such as hemorrhage of digestive tract, the big bleeding of canker, hematochezia, metrorrhagia and metrostaxis, Tuberculous purulence ulcer and chronic osteomyelitis." materia medica ": ground
Elm bitter cold is the special agent of cool blood." detailed outline ": garden burnet controls stool and urine blood trouble except lower burnt heat." book on Chinese herbal medicine is looked for the truth ": garden burnet, all books are all
Yan Yinqi bitter cold can then enter lower burnt blood system except heat, know in order to heat from lower solution." book on Chinese herbal medicine is just ": improving eyesight of relieving inflammation or internal heat.It controls with turbid anal fistula, produces
Negative gas scatters and disappears afterwards.Also night sweat is held back, hot ruffian is treated." haigoushen ": hemostasis dysentery loses purulence.
Peppermint acrid flavour, it is cool in nature, it is one of Chinese conventional Chinese medicine.Peppermint has medical and edible dual function, it is Xin Liang
Property sweating antipyretic medicine, peppermint contain menthol, which can pure and fresh pleasant pharmacological property." detailed outline ": peppermint, pungent to dissipate, cool energy
Clear benefit, specially in Xiaofeng San heat." drugization justice ": peppermint, acrid flavour can dissipate, cool in nature and clear, and the meeting of six sun of tonneau is first, dispel all heat
Ailment said due to cold or exposure " book on Chinese herbal medicine newly organized ": peppermint, not special kind solution ailment said due to cold or exposure, outstanding kind solution is melancholy, with rhizoma cyperi with relieve stagnation, if not with peppermint relieve stagnation more
Mind.Peppermint enters the warp of liver and gallbladder, is apt to the semi-exterior-interior heresy of solution, more light clear compared with radix bupleuri." book on Chinese herbal medicine is looked for the truth ": peppermint, smell are pungent cool.
Tea oil has bactericidal antiphlogistic, convergent effect.Most important chemical component be to Meng's ethylene (terpinene),
Dipentene (pinene), limonene (limonene), cineol (cineole), sesame oil brain (terpineol), anisoxide
(cumene).Tea oil originates in Australia, is the extract of tea tree.Tea oil effect has bactericidal antiphlogistic, restrains pore, treatment
Cold, cough, rhinitis, asthma improve dysmenorrhea, irregular menstruation and genital infection.Suitable for oiliness and acne-prone skin, control
It treats suppurative wound and burns, tans severely, athlete's foot and dandruff.It clears the head, rejuvenates, anti-depression.
Cocamidopropyl propyl amide hydroxy sulfo lycine is a kind of amphoteric ion surface with excellent dissolubility and compatibility
Activating agent, a kind of zwitterionic surfactant all have excellent stability under acid and alkaline condition, and sun is presented respectively
And anionic property, it is often used in combination with anions and canons and nonionic surfactant, compatibility is good.Nontoxic, irritation is small,
Soluble easily in water, to ph stability, foam is more, strong detergency, have excellent thickening property, flexibility, bactericidal properties, antistatic property,
Hard water resistance property.Softness, conditioning and the low-temperature stability of washing class product can be significantly improved.Product characteristic: 1. have excellent dissolution
Property and compatibility；2. having excellent foaminess and significant thickening property；3. having low irritant and bactericidal properties, compatible use energy
Significantly improve softness, conditioning and the low-temperature stability of washing class product；4. having the hard water resistance property more excellent than CAB, antistatic
Property and biological degradability；5. the sulfobetaines of acid amide type has better mildness and spumescence and foam stability；6. pair soap base
There are thickening properties.It is widely used in middle-and-high-ranking shampoo, in bath foam；It is to prepare mild shampoo for baby, baby's bubble bath, baby skin protection
The main component of product；It is a kind of excellent softening amendment in hair care and skin care formula；Also act as detergent, wetting
Agent, thickener, antistatic agent and fungicide etc..
Cocounut oil acyl both sexes base diethyl acid disodium is that have excellent foam stabilizing, wetting, antistatic, foaming, dispersion, emulsification, seep
Saturating ability, mild surfactant.The irritation of other surfaces activating agent can be reduced, resistance to hard water, compatibility is good.Appearance: colourless
To light yellow viscous liquid.Dissolubility: it is dissolved in water.Stability: stablize.Risk: there is irritation.To skin, eyes have compared with
Low irritation.It is ecological: may be harmful to environment, water body should be given and paid special attention to.Biological degradability: degradable.It is special
Different item: it can be applied to infant's cleaning product.CIR safety evaluation: nontoxic in acute oral toxicity research.These chemical combination
The Eye irritation result of study of object changes according to experimental condition.It is 28.1% coconut palm containing mass fraction in Clinical Ophthalmology research
The volume fraction of the shampoo of oily both sexes diethyl acid disodium is that 1%, 3% and 10% dilution is nonirritant to human eye.Cocounut oil two
Property diethyl acid disodium all has non-mutagenicity in bacteria-measuring, regardless of whether there is metabolism activation.It is tried in duplicate damage patch
In testing, the cocounut oil both sexes sodium acetate that mass fraction is 10% is not that stimulant is also not sensitizer.CIREP draws a conclusion, these
Ingredient can be used safely in personal care product.According to the general provision of European Union's cosmetics regulation, cocounut oil both sexes diethyl acid disodium can
For in the cosmetics and personal care product of European market.
Amino acid N MF-50 moisturizer Methylglycine is a kind of efficient moisture-retention agent of amphoteric ion type, naturally occurring
In fructus lycii, kelp.NMF-50 moisturizer effect is identical as hyaluronic acid, can be safely used for cosmetics and washing class product
In.NMF-50 moisturizer is that a kind of absorption is fast, the high new moisturizer of activity, can be rapid in the application of personal care product
Improving the moisture holding capacity of skin and hair, the vigor of activated cell has and skin is kept to moisten, and it is smooth, it prevents from having dry skin
With the effect of obfuscation.Amino acid N MF-50 moisturizer belongs to pure natural structural material, and natural intrinsic moisturizing ingredient, it keeps moisture
Ability it is all stronger than any natural or synthetic polymer.Performance of keeping humidity is 12 times of glycerol.With high biological compatibility, pole
It is soluble easily in water, very heat-resisting, acidproof and alkaline-resisting and applied widely, easy to operate, safety and stability.Due to being widely present in
In Foods, non-correlation toxicity explanation.
1-2 propylene glycol is the important original of unsaturated polyester (UP), epoxy resin, polyurethane resin, plasticizer, surfactant
Material, this unsaturated polyester (UP) are largely used to surface coating and reinforced plastics.The viscosity and good hygroscopicity of 1-2 propylene glycol, food,
Hygroscopic agent, antifreeze, lubricant and solvent are widely used as in medicine and cosmetics industry.In the food industry, propylene glycol and rouge
The reaction of fat acid generates methyl glycol fatty acid ester, is mainly used as food emulsifying agent；Propylene glycol is the fine solvent of flavouring and pigment.
Since toxicity is low, it is used as the solvent of fragrance, edible pigment in the food industry.Victim is not yet found so far.Rat vein note
Penetrating and be injected intraperitoneally LD50 is 7000--8000mg/kg, LD50 of passing through mouth 2800mg/kg.The 1-2 propylene glycol of low dosage is to human body
Be it is harmless, be used in this specification can 1-2 propylene glycol used in food, and mass fraction is only 0.5%.
Lactic acid is a kind of compound, it works in a variety of Biochemical processes.Sterling is colourless liquid, and industrial goods are
It is colourless to arrive light yellow liquid.Odorlessness has hygroscopicity.Relative density 1.2060 (25/4 DEG C).18 DEG C of fusing point.122 DEG C of boiling point
(2kPa).Refractive index nD (20 DEG C) 1.4392.Can be miscible with water, ethyl alcohol, glycerol, aqueous solution is in acidity, PKa=3.85.It is insoluble
In chloroform, carbon disulfide and petroleum ether.Heat resolve under normal pressure when being concentrated into 50%, partially becomes lactic anhydride, therefore product
In lactic anhydride often containing mass fraction 10%~15%.Due to that under certain condition, can be esterified with hydroxyl and carboxyl
Reaction, there are three types of products.Toxicity: rat oral LD50 is 3.73g/kg weight；ADI is provided without limitation.There are two types of same point for lactic acid
Isomers: D- type and L-type.Rat is divided into three groups, every group of dosage is DL- type, D- type and the L-type of 1.7g/kg weight
Lactic acid dissects detection after taking orally three hours, and DL- type lactic acid can be such that glycogen in liver increases, 40%~95% in 3h sorption enhanced；
D- type and L-type lactic acid increase lactate in blood, are excreted by urine.Lactic acid has very strong anti-corrosive fresh-keeping effect, can be used in
Fruit wine, beverage, meat, food, cake production, vegetables (olive, cuke, pearl onion) are pickled and can processing, grain
Processing, the storage of fruit, have adjust pH value, it is antibacterial, extend the shelf life, season, keeping food color, raising product quality etc.
Effect is that a part of the intrinsic natural moisturizing factor of skin is widely used as the moisturizing agent of many skin care item due to lactic acid.Pfansteihl
It is a kind of most effective AHA and irritation is little；Lactic acid only adjusts pH value in this specification, and uses edible cream
Acid, concentration is also relatively low, and safety is high.
Eclipta, honeysuckle, garden burnet, sophora flower, peppermint, tea oil cooperate with together, have clearing heat and detoxicating, swelling and pain relieving, suppression
The effect of bacterium is antipruritic, cooling blood and hemostasis, holds back solid anti-avulsion, the cocounut oil acyl hydroxysultaine being added thereto, cocounut oil acyl both sexes base
Diethyl acid disodium is amphoteric surfactant, primarily serves decontamination and the effect of light degreasing, amino acid N MF-50 moisturizer master
Play the role of moisturizing skin, moisten anticracking, 1-2 propylene glycol is mainly used for drug snap action in skin surface, sodium chloride
For the consistency of anti-inflammatory and adjusting lotion, lactic acid only is used to adjust the pH value of lotion.After the above main and supplementary materials are comprehensive, Ke Yiqi
Just slag just stain in rapid cleaning crissum anal canal, while Chinese medicine is the skin surface fast-acting the effect of.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all in essence of the invention
Within mind and principle, any modification, equivalent replacement, improvement and so on be should all be included in the protection scope of the present invention.
In addition, it should be understood that although this specification is described in terms of embodiments, but not each embodiment is only wrapped
Containing an independent technical solution, this description of the specification is merely for the sake of clarity, and those skilled in the art should
It considers the specification as a whole, the technical solutions in the various embodiments may also be suitably combined, forms those skilled in the art
The other embodiments being understood that.
Claims (9)
1. a kind of Chinese medicine composition for hemorrhoid anal fissure, which is characterized in that the raw material including following parts by weight: honeysuckle 5-10
Part, 3-8 parts of eclipta, 2-6 parts of sophora flower, 2-6 parts of garden burnet, 0.5-1 parts of peppermint, 10-15 parts of surfactant, amino acid 0.3-
0.75 part, 0.4-0.6 parts of 1-2 propylene glycol and 0.35-0.7 parts of tea oil.
2. the Chinese medicine composition according to claim 1 for hemorrhoid anal fissure, which is characterized in that including following parts by weight
Raw material: 6-9 parts of honeysuckle, 4-7 parts of eclipta, 3-6 parts of sophora flower, 3-6 parts of garden burnet, 0.7-1.1 parts of peppermint, surfactant 10-
15 parts, 0.38-0.75 parts of amino acid, 0.46-0.6 parts of 1-2 propylene glycol and 0.42-0.7 parts of tea oil.
3. the Chinese medicine composition according to claim 1 for hemorrhoid anal fissure, which is characterized in that the surfactant packet
Include cocounut oil acyl hydroxysultaine, cocounut oil acyl both sexes diethyl acid disodium and sodium chloride.
4. a kind of preparation method of the Chinese medicine composition a method according to any one of claims 1-3 for hemorrhoid anal fissure, feature exist
In, the specific steps are as follows:
Eclipta, honeysuckle, sophora flower, garden burnet and peppermint are ground into powder, obtain smashed eclipta, gold and silver by step 1
Flower, sophora flower, garden burnet and peppermint；
Smashed eclipta, honeysuckle, sophora flower and garden burnet are added to the water immersion 25-40 minutes, are heated to 92- by step 2
95 DEG C and decoction 0.8-1.4 hour is stirred, the 4-8 minutes smashed peppermints of addition before decoction terminates, then be centrifuged, mistake
Filter, merging filtrate and is condensed into thick paste at squeezing；
Thick paste is added to the water and is stirred evenly, obtains solution by step 3；
Step 4, by surfactant, amino acid, 1-2 propylene glycol and tea oil is added to the water and homogenization, then thereto
Solution is added, finally with newborn acid for adjusting pH value, different preparations is obtained using corresponding technique.
5. the preparation method of the Chinese medicine composition according to claim 4 for hemorrhoid anal fissure, which is characterized in that the step
The partial size of powder is 0.4-0.6cm in rapid one.
6. the preparation method according to claim 5 or 4 for the Chinese medicine composition of hemorrhoid anal fissure, which is characterized in that institute
Stating in step 2 further includes that thick paste is dried in vacuo and is crushed, and obtains the first mixture, mixes in step 3 by first at this time
Object is closed to be added to the water and stir evenly.
7. the preparation method of the Chinese medicine composition according to claim 3 for hemorrhoid anal fissure, which is characterized in that the step
Preparation includes any one in lotion, gel, capsule, tablet, suppository, paste and powder in rapid four.
8. a kind of Chinese medicine composition a method according to any one of claims 1-3 for hemorrhoid anal fissure is in preparation for preventing and treating
Hemorrhoid, anal fissure drug in application.
9. the Chinese medicine composition according to claim 8 for hemorrhoid anal fissure is in preparation for preventing and treating hemorrhoid, anus
The application method in drug split is directly to clean anal canal skin.
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| CN114533859A (en) * | 2022-02-23 | 2022-05-27 | 宁波项谨记百货有限公司 | Traditional Chinese medicine ointment for treating haemorrhoids and preparation method thereof |
| CN116763850A (en) * | 2020-07-06 | 2023-09-19 | 许颢瀚 | Formula for efficiently dredging constipation and inhibiting hemorrhoids and polyps |
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