CN110327407A - A kind of nasal drop - Google Patents

Abstract

This application involves technical field of traditional Chinese medicine preparation, a kind of nasal drop is specifically disclosed, the raw material including following weight ratio ingredient: 80-100 parts of cordate houttuynia, 80-100 parts of Centipeda minima, 80-100 parts of Glabrous Sarcandra Herb, 80-100 parts of dayflower, 70-90 parts of purslane, 80-90 parts of the achene of Siberian cocklebur, 100-106 parts of Flos Magnoliae Liliflorae, 70-80 parts of rhizoma acori graminei, 50-60 parts of Chinese ephedra, 0.1-1 parts of borneol.This nasal drop is significant in efficacy, can be obviously improved the oedema situation of sinunasal mucous membrane, restores nasal airflow, improves nasal cavity drainage, reduces nasal secretion, mitigates inflammatory reaction, while avoiding causing the side effects such as rhinitis medicamentosa, mycteroxerosis and drug dependence.

Description

A kind of nasal drop

Technical field

The present invention relates to technical field of traditional Chinese medicine preparation, in particular to a kind of nasal drop.

Background technique

Acute sinusitis refers to the acute suppurative inflammation of nasal cavity, sinus mucosa, and serious person can be involved sclerotin, and can Cause the accompanying infection of surrounding tissue and adjacent organs, is hals,Nasen und Ohrenheilkunde common disease often secondary to acute rhinitis.Research in recent years Think that the reasons such as nasal sinus anatomical structure exception, bacterium infection are an important factor for causing acute sinusitis, for acute nose- The pathogenesis of nasosinusitis mostly uses nasal cavity applied medicine (decongestant in nasal cavity), antibiotic, glucocorticoid, puncture antral The treatment methods such as flushing, nasal surgery.Puncture antral rinses and the pain of operative treatment makes many patients be difficult to receive, Decongestant (common ephedrine class nasal drop) is first choice in general nasal cavity, rapid-action, can alleviate rhinostegnosis symptom rapidly, but stop The symptoms such as rhinostegnosis are easy to recur after medicine, are used for a long time and easily cause rhinitis medicamentosa, and high blood pressure, diabetes, children etc. again Inconvenience uses；So far clinically still lack the effective and lesser drug of side effect and method.

It is a kind of significant in efficacy therefore, it is necessary to develop going out, it can be obviously improved the oedema situation of sinunasal mucous membrane, restored Nasal airflow improves nasal cavity drainage, reduces nasal secretion, mitigates inflammatory reaction, while avoiding causing rhinitis medicamentosa, nasal cavity The nasal drop of the side effects such as dry and drug dependence.

Summary of the invention

In view of the shortcomings of the prior art, the technical problem to be solved by the present invention is to provide a kind of nasal drop, the nasal drop curative effect Significantly, it can be obviously improved the oedema situation of sinunasal mucous membrane, restore nasal airflow, improve nasal cavity drainage, reduce nasal cavity point Secretion mitigates inflammatory reaction, while avoiding causing the side effects such as rhinitis medicamentosa, mycteroxerosis and drug dependence.

To solve the above-mentioned problems, the technical scheme adopted by the invention is that: a kind of nasal drop, the nasal drop include such as The raw material of lower weight ratio ingredient: 80-100 parts of cordate houttuynia, 80-100 parts of Centipeda minima, 80-100 parts of Glabrous Sarcandra Herb, dayflower 80- 100 parts, 70-90 parts of purslane, 80-90 parts of the achene of Siberian cocklebur, 100-106 parts of Flos Magnoliae Liliflorae, 70-80 parts of rhizoma acori graminei, 50-60 parts of Chinese ephedra, 0.1-1 parts of borneol.

The technical principle of the technical program are as follows: inflammation belongs to traditional Chinese medicine nasosinusitis scope.Its etiology and pathogenesis is mostly the heresy for experiencing wind-heat Or the heresy of chill enters innerization heat, the turbid tears of heat toxin block nose key and form.

Nasosinusitis category Chinese medicine " nasosinusitis ", " brain leakage " scope.Nasosinusitis is not mostly solid by the deficiency of vital energy, exopathogen invasion, and heresy entering heat is burnt Saprophytic purulence, is detained empty key, disperse empties, and is unable to distinguish between the clear and the muddy, the occlusion of key gap, is led to that nasal congestion, headache alliteration, intelligence is faint, body Tired limb is tired, normal easy exogenous disease.Exogenous disease posterior nasal sinuses are scorching to be aggravated again, such reciprocal causation, recurrent exerbation.

Allergic rhinitis category Chinese medicine " allergic rhinitis " scope, the generation of allergic rhinitis, internal cause are mostly visceral dysfunction, and external cause is mostly to feel Have a cold, the heresy of different gas and cause, visceral dysfunction with lung, spleen, kidney it is deficient based on, disease mainly in lung, but with spleen, kidney close System is close.

Treatment rhinitis, nasosinusitis and allergic rhinitis can use pungent scattered resuscitation with aromatics, and with clearing heat and detoxicating method.Select goose not in side Food grass is monarch, acrid flavour, warm-natured, there is the function of sensible cold dispelling, expelling wind and removing dampness, eliminating stasis to subdue swelling.Compendium of Material Medica is recorded: " sandwort Grass above reaches brains, and controls top pain mesh disease, leads to nose gas and falls Xi meat." " collected statements on the herbal foundation " also call it: " sharp nine orifices leads to the medicine of nose gas ".Clinically You Shanzhi rhinitis chronic or allergic rhinitis.Achene of Siberian cocklebur expelling cold, eliminating, clearing the nasal passage, wind-damp dispelling, analgesic；The flower bud of lily magnolia Hua Xin dissipates temperature and leads to, and fragrance is walked to alter, uplink head, is apt to clearing the nasal passage；Rhizoma acori graminei is had one's ideas straightened out slit phlegm, vital energy regualting and blood circulation-promoting, and relieve heat is dried；Borneol is logical All keys dissipate stagnated fire, swelling and pain relieving.Four medicines are minister, and principal drug assistance dispersing superficial exopathogens declare clearing the nasal passage.Dayflower, purslane, cordate houttuynia are equal Clearing heat-fire removing toxic substances, there are also the function of removing pus and relieving carbuncle for cordate houttuynia, and for exterior evil inward invasionization heat, cause nose rhinorrhea person effect is good；Glabrous Sarcandra Herb Dispelling wind and eliminating dampness, promoting blood circulation and stopping pain；Chinese ephedra inducing sweat and dispelling exogenous evils.Five medicines are adjutant.All medicines share, and can dispel exopathogen, clearing the nasal passage.

The beneficial effect that this programme generates is: there is clearing heat and detoxicating, dehumidifying to dispel turbid, the effect of awakening consciousness, for anxious, slow Property rhinitis, nasosinusitis (nasosinusitis), allergic rhinitis (allergic rhinitis), it is curative for effect.By clinical observation its with anti-inflammatory sensible, disease-resistant Poison, vasoconstriction enhance the anti-immunity function of body.Through clinic trial, significant effect can be obviously improved sinunasal mucous membrane Oedema situation, restore nasal airflow, improve nasal cavity drainage, reduce nasal secretion, mitigate inflammatory reaction, while avoiding and drawing Play the side effects such as rhinitis medicamentosa, mycteroxerosis and drug dependence.

Further, following components are whole by weight, 100 parts of cordate houttuynia, 100 parts of Centipeda minima, 90 parts of Glabrous Sarcandra Herb, duck plantar Careless 80 parts, 70 parts of purslane, 85 parts of the achene of Siberian cocklebur, 100 parts of Flos Magnoliae Liliflorae, 80 parts of rhizoma acori graminei, 50 parts of Chinese ephedra, 1 part of borneol.

Further, following components are whole by weight, 80 parts of cordate houttuynia, 80 parts of Centipeda minima, 100 parts of Glabrous Sarcandra Herb, duck plantar Careless 95 parts, 80 parts of purslane, 81 parts of the achene of Siberian cocklebur, 106 parts of Flos Magnoliae Liliflorae, 80 parts of rhizoma acori graminei, 50 parts of Chinese ephedra, 1 part of borneol.

Further, following components are whole by weight, 100 parts of cordate houttuynia, 80 parts of Centipeda minima, 100 parts of Glabrous Sarcandra Herb, duck plantar Careless 98 parts, 85 parts of purslane, 83 parts of the achene of Siberian cocklebur, 103 parts of Flos Magnoliae Liliflorae, 78 parts of rhizoma acori graminei, 55 parts of Chinese ephedra, 0.1 part of borneol.

Further, following components are whole by weight, 90 parts of cordate houttuynia, 90 parts of Centipeda minima, 80 parts of Glabrous Sarcandra Herb, dayflower 80 parts, 78 parts of purslane, 90 parts of the achene of Siberian cocklebur, 101 parts of Flos Magnoliae Liliflorae, 76 parts of rhizoma acori graminei, 53 parts of Chinese ephedra, 0.5 part of borneol.

Further, following components are whole by weight, 80 parts of cordate houttuynia, 85 parts of Centipeda minima, 92 parts of Glabrous Sarcandra Herb, dayflower 94 parts, 90 parts of purslane, 87 parts of the achene of Siberian cocklebur, 105 parts of Flos Magnoliae Liliflorae, 73 parts of rhizoma acori graminei, 58 parts of Chinese ephedra, 0.3 part of borneol.

Further, the nasal drop is made of following steps:

(1) prepare the raw material of following weight ratio ingredient: 80-100 parts of cordate houttuynia, 80-100 parts of Centipeda minima, Glabrous Sarcandra Herb 80- 100 parts, 80-100 parts of dayflower, 70-90 parts of purslane, 80-90 parts of the achene of Siberian cocklebur, 100-106 parts of Flos Magnoliae Liliflorae, rhizoma acori graminei 70-80 Part, 50-60 parts of Chinese ephedra, 0.1-1 parts of borneol；

(2) Flos Magnoliae Liliflorae, two taste medicine of rhizoma acori graminei are mixed, the water of 10-12 times of medicinal material weight is added, be put into liquid vacuum concentration In boiling machine, aqua aromatica is decocted and extracted and collect under a reduced pressure, it is spare；

(3) remaining Aqueous extracts in step (2) are filtered while hot, obtains medical fluid I, discards the dregs of a decoction；

(4) aqua aromatica in step (2) is subjected to redistillation at 60-72 DEG C, the aqua aromatica for collecting redistillation is spare；

(5) cordate houttuynia, Centipeda minima, Glabrous Sarcandra Herb, dayflower, purslane, the achene of Siberian cocklebur and Chinese ephedra seven flavor medicine are mixed, is added 11-15 times of medicinal material weight measures water decoction, keeps 0.8-1.2 hours slightly boiled, separates decocting liquid while hot and obtain medical fluid II；

(6) merge medical fluid I, medical fluid II, normal pressure is concentrated into solid-liquid ratio 1.31-1.34g/ml, obtains water drug-decocting concentrating liquid；

(7) water drug-decocting concentrating liquid is centrifuged in centrifuge, divides and takes supernatant；

(8) clear liquid is mixed with the aqua aromatica of redistillation, stirs and evenly mixs and mentions medical fluid up to nasal drop water.

(9) 1Xg polyethylene glycol is added in the medicinal alcohol of 20Xml 95%, borneol is added after stirring and dissolving, stirs molten After solution it is a small amount of it is multiple be added in final extracting solution, it is stirring while adding, finally plus distilled water to 1000Xml to get nasal drop (X is multiple).

Further, the 8-12 times of water that the dregs of a decoction in step (5) sequentially add medicinal material weight is decocted, and repeated 1-3 times, It decocts every time and is kept for slightly boiled 0.8-1.2 hours, separate each decocting liquid while hot, merge multiple decocting liquid, obtain medical fluid II.

By repeatedly decocting, discharge the effective component in drug sufficiently into medical fluid.

Further, the vacuum degree in step (2) is 0.07-0.08MPa, and by mixed material heating to 80-87 DEG C.

The boiling point of liquid reduces under vacuum, is more advantageous to aroma substance and evaporates.

Further, the time for extracting aqua aromatica is 4-7 hour, is collected every a hour primary.

Trial test shows (vacuum degree 0.07-0.08MPa) under a reduced pressure, rhizoma acori graminei and the flower bud of lily magnolia at 80-87 DEG C 4-7 hour is extracted, volatile oil extracts completely substantially.

Further, the time being centrifuged in step (7) is 1-5min, and revolving speed is that 1000-5000 turns/min.

Precipitation and separation facilitates effective component extracting.

Further, ethyl hydroxy benzoate is added during producing final extracting solution in step (9).

Ethyl hydroxy benzoate is used as preservative.

Further, the molecular weight of polyethylene glycol is 600.

The nasal drop of this backup method preparation processed is liquid, and PEG400 and PEG 600 are liquid reagent, are more suited to this Liquid preparation, which is added, to be used, and commercially available medicinal PEG600 is cheap relative to medicinal PEG400, therefore selects medicinal PEG600.

Further, the 8-12 times of water that the dregs of a decoction in step (5) sequentially add medicinal material weight is decocted, and repeated 1-3 times, It decocts every time and is kept for slightly boiled 0.8-1.2 hours, separate each decocting liquid while hot, merge multiple decocting liquid, obtain medical fluid II.

By repeatedly decocting, discharge the effective component in drug sufficiently into medical fluid.

Further, the vacuum degree in step (2) is 0.07-0.08MPa, and by mixed material heating to 80-87 DEG C.

The boiling point of liquid reduces under vacuum, is more advantageous to aroma substance and evaporates.

Further, the time for extracting aqua aromatica is 4-7 hour, is collected every a hour primary.

Trial test shows (vacuum degree 0.07-0.08MPa) under a reduced pressure, rhizoma acori graminei and the flower bud of lily magnolia in 80-87 DEG C of item Part

Lower 4-7 hour of extraction, volatile oil extract completely substantially.

Further, the time being centrifuged in step (7) is 1-5min, and revolving speed is that 1000-5000 turns/min.

Precipitation and separation facilitates effective component extracting.

Further, ethyl hydroxy benzoate is added during producing nasal drop in step (9).

Ethyl hydroxy benzoate is used as preservative.

Further, the molecular weight of polyethylene glycol is 600.

The nasal drop of this backup method preparation processed is liquid, and PEG400 and PEG 600 are liquid reagent, are more suited to this Liquid preparation, which is added, to be used, and commercially available medicinal PEG600 is cheap relative to medicinal PEG400, therefore selects medicinal PEG600.

Further, repeatedly decoct seven taste mixing Chinese medicines and use following equipment: including pot body, the bottom of pot body is provided with heating Plate, electric hot plate are electrically connected with power supply and heater switch；The bottom of pot body offers first through hole, and it is logical that second is offered in heating plate Hole, first through hole are aligned with the second through-hole and pass through pipeline and be connected to, and the second through-hole lower end is connected with liquid storage pot, the second through-hole and storage Tapping valve is provided between liquid pot；Pot nside is provided with the fixed link arranged in the horizontal direction, and the rotation of fixed link periphery is arranged There is rotating cylinder, the side wall of rotating cylinder is made by sieve tray；Rotating cylinder can rotate in pot body；One end of fixed link passes through L-type connecting rod It is fixedly connected with the telescopic shaft for the cylinder being arranged in a vertical direction；The periphery fixing sleeve of rotating cylinder is equipped with first bevel gear, and first is logical Hole allows first bevel gear to pass through when rotating；First bevel gear is engaged with second bevel gear, and fixed be set in of second bevel gear turns On axis, shaft is driven by motor, and shaft is fixedly connected with the output shaft of motor, and motor is fixed on the telescopic shaft of cylinder, cylinder It is electrically connected to a power source, cylinder is electrically connected with switching cylinder；Motor is electrically connected to a power source, and motor is electrically connected with motor switch.

For rotating cylinder for filling Chinese medicine, Telescopic-cylinder can drive rotating cylinder to move up and down, and motor rotation drives second bevel gear to turn Dynamic, second bevel gear rotate driving first bevel gear rotation, first bevel gear rotation drives drum rotation, thus in rotating cylinder Medicinal material can stir, and come out the active principle in Chinese medicine by decoction as much as possible；It, will using cylinder after decoction Rotating cylinder is lifted up, and the dregs of a decoction and medical fluid are automatically separated, and then medical fluid is discharged into liquid storage pot by tapping valve, is then shut off drain Valve similarly carries out subsequent 1-3 decoction, and the medical fluid repeatedly decocted is stored in liquid storage pot, and the dregs of a decoction are retained in rotating cylinder.

Further, the pot body is barrel-shaped, and the lid matched with pot body is provided in shaft, and lid includes the first lid Body and the second lid, the second lid be it is discoid, the second lid fixation is set on L-type connecting rod, on the second lid far from L-type connect The first lid is cut in one end of bar, the first lid is collar plate shape, and the first lid is rotated through the second lid and with the second lid Connection, the first lid are fixed in the shaft above second bevel gear；First lid and shaft are the same as arrangement；When rotating cylinder bottom with When the interior bottom fitting of pot body, lid can cover the oral area of pot body.

Lid is set, effective component (especially fragranced substance) can be prevented to volatilize, and the steaming of moisture can be reduced Hair and heat preservation.

Further, open at one end of the rotating cylinder far from L-type connecting rod and it is threaded with capping.

Facilitate pick-and-place Chinese medicine.

Further, the rotating cylinder internal circumferential is evenly arranged with shovelling plate.

What shovelling plate can enhance Chinese medicine stirs effect.

Further, arc-shaped sliding slot is offered on the second lid, sliding slot is located on the edge of the inside of the second lid, sliding The oral area of slot offers blind hole towards the first lid on the first lid, the axis of blind hole along the first lid radial direction, it is sliding in blind hole Dynamic to be connected with sliding block, one end that sliding block is contacted with the second lid is the radius one of hemisphere face and the cross section of radius and sliding slot It causes, is provided with spring in sliding slot, one end of spring is fixed on blind via bottom, and the other end of sliding slot is fixed on sliding block, blind hole Upside offers the third through-hole that can will be connected to inside blind hole with the top of the first lid, and offering on the downside of blind hole can be by blind hole The fourth hole that is connected to the lower section of the first lid of inside, is coaxially arranged with sponge inside blind hole, sponge be set in spring outside Week；When sliding block is located inside blind hole, sliding block can extrude sponge and can will block between fourth hole inside blind hole；Work as sliding block When skidding off blind hole, sponge extends naturally just, is blocked between third through-hole and blind hole inside by sponge, in third through-hole and blind hole Gas is allowed to pass through between portion；Fourth hole is connected to blind hole inside always.

When sliding block is aligned with sliding slot, sliding block is caught in sliding slot under the elastic force of spring, and sponge extends naturally and by top Third through-hole block, thus between third through-hole and fourth hole allow gas pass through, so that the water below the first lid steams For gas after sponge adsorption moisture, gas can drain into the top of the first lid, can pressure release in pot body；First lid continues to rotate, Sliding block is reset to inside blind hole and is squeezed under the extruding of the second lid sponge and will block between third through-hole and blind hole, pot In vivo can pressure maintaining, the moisture squeezed out in sponge is back to pot body through fourth hole, realizes the sustainable adsorption moisture of sponge, aromatic substance The irritation taste of matter and Chinese medicine.

Detailed description of the invention

Fig. 1 is the overall structure figure of the embodiment of the present invention.

Fig. 2 is the cross-sectional view of rotating cylinder vertical direction.

Fig. 3 is the cross-sectional view of lid horizontal direction.

Fig. 4 is the portion A enlarged drawing in Fig. 1.

Specific embodiment

It is further described below by specific embodiment:

Appended drawing reference in Figure of description includes: pot body 10, first through hole 11, heating plate 12, the second through-hole 13, draining Valve 14, liquid storage pot 15, supporting leg 16, rotating cylinder 20, shovelling plate 201, fixed link 21, L-type connecting rod 22, cylinder telescopic shaft 23, first Bevel gear 24, second bevel gear 25, shaft 26, motor 27, capping 28, limit plate 29, lid 30, the first lid 301, second lid Body 302, blind hole 31, sliding block 32, spring 33, third through-hole 34, fourth hole 35, sliding slot 36, sponge 37.

The weight for forming each drug component of nasal drop is as shown in table 1:

Table 1

Table 2: the value of each parameter of the preparation method of nasal drop of the present invention

Table 2

The difference of each embodiment be only that the weight of each component in raw material by be changed in table 1 and each technological parameter by According to being changed in table 2, this is specifically illustrated for sentencing embodiment 1:

Embodiment 1

The preparation method of nasal drop includes the following steps:

(1) prepare cordate houttuynia 100g, Centipeda minima 100g, Glabrous Sarcandra Herb 90g, dayflower 80g, purslane 70g, the achene of Siberian cocklebur 85g, Flos Magnoliae Liliflorae 100g, rhizoma acori graminei 80g, Chinese ephedra 50g, borneol 1g；

(2) Flos Magnoliae Liliflorae, two taste medicine of rhizoma acori graminei are mixed, the water of 2160g is added, be put into liquid vacuum concentration boiling machine (north Jingdone district Hua Yuan Medical Equipment Co., Ltd., model: YZN50) in, it is 0.07MPa in vacuum degree, heats the mixture to 80 It is decocted under the conditions of DEG C, and is extracted by distillation condensation and collect aqua aromatica, the time for extracting aqua aromatica is 4 hours, Mei Geyi It collects within a hour once, it is spare；

(3) remaining Aqueous extracts in step (2) are filtered while hot, obtains medical fluid I, discards the dregs of a decoction；

(4) aqua aromatica in step (2) is poured into liquid vacuum concentration boiling machine (producer: eastization former Medical Devices in Beijing has Limit responsible company, model: YZN50) in redistillation is carried out at 70 DEG C, the aqua aromatica for collecting redistillation is spare；

(5) the remaining seven flavor medicine after removing Flos Magnoliae Liliflorae, rhizoma acori graminei and borneol is mixed, does not impregnate, is directly added into advance 11 times of amount water of medicinal material weight decoct (3 times of water need to be added for the first time by decocting), are kept for slightly boiled 0.8 hour, separate decocting liquid while hot, the dregs of a decoction are again Successively plus 8 times of water decoct 1 time with method, take decocting liquid with method point, merge decocting liquid twice, obtain medical fluid II.

(6) merge medical fluid I, medical fluid II, normal pressure be concentrated into solid-liquid ratio (quality of solid " material " with as leaching liquor The ratio of the volume of " liquid ") 1.31g/ml, obtain water drug-decocting concentrating liquid；

(7) by water drug-decocting concentrating liquid in centrifuge (producer: Anting Scientific Instrument Factory, Shanghai, model: GL-16G-II) from The heart, the time of centrifugation are 1min, and revolving speed is 4000 turns/min, divide and take supernatant；

(8) clear liquid is mixed with the aqua aromatica of redistillation, stirs and evenly mixs and mentions medical fluid up to nasal drop water.

(9) 1g Macrogol 600 and 1g ethyl hydroxy benzoate are added in the medicinal alcohol of 20ml 95%, adds after stirring and dissolving Enter borneol 1g, after stirring and dissolving it is a small amount of it is multiple be added in final extracting solution, it is stirring while adding, finally plus distilled water extremely 1000ml is to get nasal drop.

In above step, seven taste mixing Chinese medicines are wherein decocted in step (5) twice using following equipment: as shown in Figure 1, packet Include pot body 10, pot body 10 be it is barrel-shaped, pot body 10 is made of food-grade stainless steel, and the heating conduction of stainless steel is than ceramics and casserole Thermal conductivity it is good.The bottom of pot body 10 is coaxially fixed with heating plate 12, and heating plate 12 is the bottom of discoid and radius and pot body 10 The radius in portion is consistent, and heating plate 12 is electrically connected with power supply and heater switch；The bottom of pot body 10 offers first through hole 11, and first The shape of the cross section of through-hole 11 is rectangle, offers the second through-hole 13, the shape of the cross section of the second through-hole 13 in heating plate 12 Shape is rectangle, first through hole 11 and 13 consistency from top to bottom of the second through-hole and is connected to by pipeline that 13 lower end of the second through-hole is connected with out The box body (being not drawn into figure) of the upward cuboid-type of mouth, the oral area rim seal of the upper end of box body cover on the outer of the second through-hole 13 Week, the bottom of box body open up jagged, and notch is connected with liquid storage pot 15 by drain pipe, and liquid storage pot 15 is cube of upper end opening Shape, liquid storage pot 15 are threadedly coupled with drain pipe, facilitate the dismounting of liquid storage pot 15, and drain pipe is internally provided with tapping valve 14, Tapping valve 14 is shut-off valve；The bottom of heating plate 12 is fixed with supporting leg 16, and the quantity of supporting leg 16 is for 4 and circumferential uniform It is distributed in the edge of the bottom of heating plate 12.

As shown in Figure 1, pot body 10 is internally provided with the fixed link 21 arranged in the horizontal direction, 21 periphery of fixed link is arranged with Rotating cylinder 20, the right end closing of rotating cylinder 20, the left end of rotating cylinder 20 are opened wide and are threaded with capping 28, facilitate pick-and-place Chinese medicine, Gu The left end of fixed pole 21 is rotatablely connected through capping 28 and with capping 28, is threaded with limit in the fixed link 21 in 28 left side of capping Plate 29；The right end of fixed link 21 runs through the right end of rotating cylinder 20 and is rotatablely connected with rotating cylinder 20, and fixed link 21 and rotating cylinder 20 are coaxial Arrangement, the side wall of rotating cylinder 20 are made by sieve tray, and the size of sieve pore is 0.3cm；The right end of fixed link 21 is connected with L-type company Bar 22, the vertical end of L-type connecting rod 22 are fixedly connected downwards and with the right end of fixed link 21, the vertical end of L-type connecting rod 22 It is bonded with the right side of rotating cylinder 20, limit plate 29 cooperates with L-type connecting rod 22 limits rotating cylinder 20.

The horizontal ends level of L-type connecting rod 22 is fixedly connected with towards left arrangement, the left end of the horizontal ends of L-type connecting rod 22 along vertical The telescopic shaft 23 of the cylinder of direction arrangement, the structure of cylinder are existing；The periphery fixing sleeve of rotating cylinder 20 is equipped with first bevel gear 24, the width of first through hole 11 is 1.2 times of the thickness of first bevel gear 24, and 24 lower end of first bevel gear exceeds 20 lower end of rotating cylinder Length be 1.6 times of height of first through hole 11, the length of first through hole 11 is 1.2 times of 24 outer diameter of first bevel gear, is kept away Exempting from first through hole 11 stops first bevel gear 24 to rotate；24 upper end of first bevel gear is engaged with second bevel gear 25, the first cone tooth The radius of wheel 24 is twice of second bevel gear 25, and second bevel gear 25 is arranged in the horizontal direction, same among second bevel gear 25 Axis fixing sleeve is equipped with shaft 26, and shaft 26 is driven by motor 27, and shaft 26 is fixedly connected with the output shaft of motor 27, and motor 27 is solid It is scheduled on the telescopic shaft 23 of cylinder, cylinder is electrically connected to a power source, and cylinder is electrically connected with switching cylinder；Motor 27 is electrically connected with power supply It connects, motor 27 is electrically connected with motor switch.

Rotating cylinder 20 can drive rotating cylinder 20 to move up and down for filling Chinese medicine, the telescopic shaft 23 of cylinder, and the rotation of motor 27 drives Second bevel gear 25 rotates, the rotation of 25 rotate driving first bevel gear 24 of second bevel gear, the rotation band turn of first bevel gear 24 Cylinder 20 rotates, so that the Chinese medicine in rotating cylinder 20 can stir, is heated evenly Chinese medicine, on the one hand makes effective in Chinese medicine Substance is come out by decoction as much as possible, on the other hand avoids being burned；After decoction, rotating cylinder 20 is mentioned upwards using cylinder It rises, then medical fluid is discharged into liquid storage pot 15 by tapping valve 14, is then shut off tapping valve 14, similarly carry out subsequent decocting again It boils, the medical fluid decocted twice is stored in liquid storage pot 15, and the dregs of a decoction are retained in rotating cylinder 20；It, will using cylinder after decoction Rotating cylinder 20 is lifted up, and power failure machine 27, second bevel gear 25 stops operating, and second bevel gear 25 limits first bevel gear 24 Position, rotating cylinder 20 stop operating, capping 28 are removed, and can take out the dregs of a decoction in rotating cylinder 20.

To avoid equipment from reacting with drug, rotating cylinder 20, second bevel gear 25 in the present embodiment, fixed link 21, L-type Connecting rod 22, capping 28, limit plate 29 are all made of food-grade stainless steel production.

As shown in Fig. 2, 20 internal circumferential of rotating cylinder is evenly arranged with shovelling plate 201, what shovelling plate 201 can enhance Chinese medicine stirs effect Fruit.

Such as Fig. 1 and as shown in figure 3, being provided with the lid 30 matched with pot body 10 in shaft 26, lid 30 includes first Lid 301 and the second lid 302, the second lid 302 are that discoid and radius is identical as the internal diameter of pot body 10, the second lid 302 fixations are set on L-type connecting rod 22, and the first lid 301 is cut in the left end of the second lid 302, and the first lid 301 is disk Type, the first lid 301 are rotatablely connected through the second lid 302 and with the second lid 302, and the first lid 301 is fixed on the second cone In the shaft 26 of 25 top of gear；First lid 301 is with shaft 26 with arrangement；Between 20 bottom of rotating cylinder and the top of lid 30 away from Height from the inner sidewall for being equal to pot body 10, when the bottom of rotating cylinder 20 is bonded with the interior bottom of pot body 10, lid 30 can be by pot The oral area of body 10 covers.

As shown in figure 4, it is half that the place contacted on the second lid 302 with the right end of the first lid 301, which offers cross section, Circular arc-shaped sliding slot 36, sliding slot 36 are located on the edge of the inside of the second lid 302, the oral area direction first of sliding slot 36 Lid 301, the both ends of sliding slot 36 are the groove of a quarter dome shape, and the right end of the first lid 301 offers blind hole 31, blind For the axis in hole 31 along the radial direction of the first lid 301, the shape of the cross section of blind hole 31 is round and radius and sliding slot 36 cross The radius in section is consistent, and sliding block 32 is slidably connected in blind hole 31, and the left part of sliding block 32 is cylindric and radius and blind hole 31 Radius it is consistent, the right part of sliding block 32 is hemisphere face and radius is consistent with the radius of the cross section of sliding slot 36, is set in sliding slot 36 It is equipped with spring 33, one end of spring 33 is fixed on 31 bottom of blind hole, and the other end of sliding slot 36 is fixed on sliding block 32, blind hole 31 Upside offers the third through-hole 34 that can be connected to 31 inside of blind hole with the top of the first lid 301, and the downside of blind hole 31 opens up There is a fourth hole 35 that the inside of blind hole 31 can be connected to the lower section of the first lid 301, third through-hole 34 and fourth hole 35 Axis is arranged in a vertical direction, and fourth hole 35 is located at the lower left of third through-hole 34, is coaxially arranged with sea inside blind hole 31 Silk floss 37, for the sponge 37 in the present embodiment using high temperature resistant sponge, sponge 37 is set in the periphery of spring 33, and sponge 37 is circle Column and radius and blind hole 31 are consistent, and the left end of sponge 37 is fixed on the bottom of blind hole 31, and the right end of sponge 37 is fixed on cunning The left end of block 32.When sliding block 32 is located at 31 inside of blind hole, sliding block 32 can extrude sponge 37, sliding block 32 can by 31 inside of blind hole and It is blocked between fourth hole 35；When sliding block 32 skids off blind hole 31, sponge 37 extends naturally just, third through-hole 34 and blind hole 31 Between blocked by sponge 37, between 31 inside of third through-hole 34 and blind hole allow gas pass through；Fourth hole 35 always with blind hole 31 inside connections.

During first lid 301 is rotated relative to the second lid 302, when sliding block 32 is aligned with sliding slot 36, sliding block 32 are caught in sliding slot 36 under the elastic force of spring 33, and sponge 37 extends naturally and blocks the third through-hole of top 34, thus the Gas is allowed to pass through between three through-holes 34 and fourth hole 35, so that the vapor of 301 lower section of the first lid is inhaled by sponge 37 After attached water point, gas can drain into the top of the first lid 301, can pressure release in pot body 10；First lid 301 continues to rotate, sliding block 32 the inside of blind hole 31 is reset under the extruding of the second lid 302 and squeeze sponge 37 and by third through-hole 34 and blind hole 31 it Between block, in pot body 10 can pressure maintaining, the moisture squeezed out in sponge 37 is back in pot body 10 through fourth hole 35, realizes sponge 37 The irritation taste of sustainable adsorption moisture and aromatic substance and Chinese medicine.

To avoid sliding block 32 from being detached from from blind hole 31, when the first lid 301 stops rotating, make sliding block 32 by the second lid 302 squeeze.

First lid during Telescopic-cylinder can drive lid 30 is synchronous with rotating cylinder 20 to move up and down, and motor 27 rotates Body 301 keeps rotation, automatic intermittent pressure release in pot body 10.In pot body 10 during pressure release, when vapor passes through sponge 37, The irritation taste of moisture and aromatic substance and Chinese medicine in vapor is adsorbed by sponge 37, and gas can pass through 37 row of sponge To the top of the first lid 301, in pot body 10 can pressure release, the irritation taste of aromatic substance and Chinese medicine is dissolved in water and can It is returned in pot body 10 with water, reduces the loss of moisture and aromatic substance, and prevent the irritation taste of Chinese medicine from stimulating work Make the mouth and nose and respiratory tract of personnel.

The moisture for being extruded out in sponge 37 is flowed down along the bottom of the first lid 301, the rotation of the first lid 301, the The liquid of one lid, 301 bottom, which is subject to centrifugal forces, quickly to be moved on the inner sidewall of pot body 10 and in pot body 10 Side wall is back to 10 bottom of pot body, realizes the quick backflow of moisture.

As shown in Figure 1, the left side of the first lid 301 is contacted with the left inner side wall of pot body 10 during due to boiling medicine, because This sliding block 32 will not be detached from from blind hole 31, automatic intermittent pressure release in pot body 10, avoid in pot body 10 that pressure is excessive to be caused Explosion accident, and the sustainable loss for reducing moisture and aromatic substance, and prevent the irritation taste of Chinese medicine from stimulating work Make the mouth and nose and respiratory tract of personnel.

Specific implementation process is as follows:

After Chinese medicine is fitted into rotating cylinder 20, capping 28 is covered, corresponding multiple in table 2 is added in pot body 10 and (decocts for the first time Boil and add 3 times) pure water, then open switching cylinder, the downward elongated turn cylinder 20 of cylinder and lid 30 move downwardly to The bottom of rotating cylinder 20 is bonded with the interior bottom of pot body 10, at this time lid 30 by 10 oral area of pot body cover and lid 30 top with The oral area of pot body 10 flushes, and then opens heater switch and slightly boiled 0.8h is internally heated and kept to pot body 10, open heating Motor switch is opened after switch at once, the rotation of motor 27 drives the first lid 301 and second bevel gear 25 to rotate, and on the one hand the Two bevel gears 25 drive first bevel gear 24 to rotate, and first bevel gear 24 drives the rotation of rotating cylinder 20 to stir Chinese medicine, separately On the one hand the first lid 301 is rotated relative to the second lid 302, and sliding block 32 is intermittent to be cooperated with sliding slot 36, is made inside pot body 10 It can intermittent exhaust pressure relief.

After Chinese medicine is decocted for the first time, rotating cylinder 20 is lifted up using cylinder, and open tapping valve 14 for pot Medical fluid inside body 10 is expelled in liquid storage pot 15, is then shut off tapping valve 14.

Similarly second is carried out to Chinese medicine to decoct and drain into the medical fluid that second decocts in liquid storage pot 15.For the first time and Second of medical fluid decocted merges.Liquid storage pot 15 is removed conveniently to the medical fluid after making to decoct from drain pipe and enters subsequent processing.

Compared with existing decocting medicine pot, existing decocting medicine pot, which cannot achieve, carries out Chinese medicine in the case where covering lid 30 Stirring, when stirring, must be by cover liftings, and frequently uncapping will lead to temperature leak, turn over if being stirred not in time to Chinese medicine It is dynamic, then it will lead to and be burned, therefore not can guarantee the effect boiled medicine, the vapor generated during boiling medicine can take away part Chinese medicine Effective component, influence final drug effect, moisture evaporates the too fast effective component that will lead in Chinese medicine and do not discharge sufficiently into medical fluid In；And the drug-decocting equipment in the present embodiment, lid 30 can be covered while play heat preservation and water retention, rotating cylinder 20 rotates band It falls after dynamic Chinese medicine moves upwards and under self gravity, and so on, simulates the process of cooking, keep Chinese medicine heated equal It is even, while avoiding being burned, makes effective component in Chinese medicine as much as possible into the liquid, utilize the value of Chinese medicine It maximizes, guarantees the effect boiled medicine；Rotating cylinder 20 rotates the concussion that can also evoke medical fluid in pot body 10, and the work of stirring is played to medical fluid With avoiding being burned caused by the deposit in medical fluid；Fly since medicinal material can evoke the medical fluid in pot body 10 when falling It splashes, therefore lid 30 is set and can avoid outside medical fluid spillage pot body 10；Lid 30, which is arranged, can also be such that the water of drug containing volatile ingredient steams Gas is aggregated in sponge 37 with the bottom of lid 30, is become droplet and is back in pot body 10, and effective ingredient is thus reduced It loses, while avoiding taste excessive, the rotation of the first lid 301 realizes the intermittence of sliding block 32 in pot body 10 certainly with the cooperation of sliding slot 36 Dynamic intermittence pressure release, improves safety.

Table 3: toxic component measurement and index components content injury test in each embodiment in final products

Table 3

Atractyloside di-potassium is the toxic component of stir-baked FRUCCTUS XANTHII." Chinese Pharmacopoeia " (version one in 2015) regulation, fries grey contain Atractyloside should be " 0.10%-0.30% ", and the content of atractyloside exists in the nasal drop that the preparation method of this nasal drop prepares In " 0.10%-0.30% " range, meets this edition States Pharmacopoeia specifications limitation, be located at threshold limit values range.Medical fluid is first centrifuged and goes to precipitate Compared with medical fluid is not when going precipitating, index components content loss is less than or equal to 1.2%.Therefore, preparation elder generation removing impurity by means of precipitation obtains Clarified solution reduces sediment again under the premise of effectively maintaining index components content, improves finished appearance.

Drug effect performance test

One, clinical data

1. case source: all patients are all from January, 2009 to the attached doctor of in April, 2011 Guizhou university of TCM second Institute's eye hals,Nasen und Ohrenheilkunde outpatient service, totally 120.

2. diagnostic criteria:

2.1 tcm diagnosis and dialectical foundation: referring to " the Chinese medical disease diagnosis curative effect mark of State Administration of Traditional Chinese Medicine's publication It is quasi- " [7] nasosinusitis is with a large amount of purulences or sticky nasal mucus, and nasal obstruction, dizzy or headache is cardinal symptom.Can occur together heat and general malaise etc. Disease.Nasal cavity checks mucous membrane swelling, hyperemia, and nasal cavity or choana have more viscosity or purulent secretion.X-ray or nasal sinus CT take the photograph piece There is positive performance.Total white blood cells and neutrophil leucocyte, which can have, to be increased.Dialectical real example is divided into: 1. wind and heat in the lung meridian: being more common in morbidity Initial stage, mostly acute attack due to exogenous disease.Nasal obstruction, tears polychrome is white or micro- Huang, has a headache, cough is coughed up phlegm.Nasal decongestion, concha are swollen Greatly.Thin white fur of tongue, superficial and rapid pulse.2. gallbladder heat stagnation: more very, tears polychrome is yellow and turbid for nasal obstruction, headache.Body heat, it is thirsty, it is hard and dry. Nasal decongestion is obvious, and swelling, visible more purulent secretion in nasal cavity.Tongue is red, yellow and greasy fur, wiry and frequent pulse.3. damp heat in the spleen and the stomach: Nasal obstruction is heavy and continues, and yellow turbid amount is more.With nose heave, gastral cavity ruffian uncomfortable in chest, dark urine, nasal decongestion swelling has more Huang in nasal cavity Turbid secretion.Yellowish fur, slippery and rapid pulse.

2.2 Western medicine diagnostic criterias: referring to the diagnosis of " ENT & HN Surgery Dept. " [1] acute sinusitis: nasal obstruction, Purulence tears are more, headache or local compression pain, can be with a degree of dysosmia.The visible concha swelling of nasal endoscopy, nose Purulent secretion in road.It is different degrees of to influence to learn mucous membrane in auxiliary diagnosis x-ray plain film or the visible sinus cavities metamorphosis of CT and sinus cavities It thickens, sinus cavities increase in density or polyp shadow, as gathered purulent secretion in sinus cavities, then, it is seen that fluid level.

3. being included in and exclusion criteria

3.1 are included in standard:

It clarifies a diagnosis through clinic as acute sinusitis patient；

Meet traditional Chinese and western medicine diagnostic criteria, while meeting differential diagnosis in tcm is real example person；

Age 5-80 years old, men and women was unlimited, can adhere to cooperating this curer；

Body is strong, is not in the mood for, other organic disease persons such as brain, kidney.

3.2 exclusion criterias:

(1) it does not meet traditional Chinese and western medicine diagnostic criteria or Chinese medical discrimination is asthenic symptoms person；

(2) it excludes autonomous medication partner treatment person and cannot to adhere to curer；

(3) it excludes to merge rheumatoid, systemic loupus erythematosus, alcoholic cirrhosis, asthma, Lymphatic System tumour heart mucus The patients such as tumor person, burn acute infection；

(4) nursing period in pregnancy period patient is excluded；

(5) it excludes to merge other organic disease persons such as the heart, brain, kidney；

(6) other related therapeutic agents are taken for a long time or use other treatment methods, and are unable to terminator.

Research method

This research case is all from the eye hals,Nasen und Ohrenheilkunde outpatient service of the second affiliated hospital, Guizhou university of TCM, examines being included in 120 patients of disconnected standard, single-blind randomized are divided into treatment group (60) and control group (60).And consider that result may be influenced The factors such as principal element such as age, gender carry out harmonious inspection, with the comparativity (P > 0.05) between guarantee group.Two groups of treatments Front and back carries out clinical and laboratory observation and records.Avoid pungent food the foods such as seafood during two groups of treatments, pays attention to being detached from dust etc. Risk factor.If there is discomfort, should all go to a doctor in time.

Case grouping

1.1 treatment groups totally 60, wherein male 28, female 32, max age 75 years old, minimal ages 8 years old, 20 years old or less 6 People, 20-30 years old 30 people, 40-50 years old 10 people, 60 years old or more 7 people, average age 37.65 ± 15.92 years old.

1.2 control groups totally 60, male 26 people, female 34, max age 74 years old, minimal ages 9 years old, 20 years old or less 8 people, 20-30 years old 26 people, 40-50 years old 22 people, 60 years old or more 4 people, average age 37.32 ± 14.86 years old.Through statistics two groups between gender and Difference that age, there are no significant, is comparable (P > 0.05).

Medicine preparation

2.1 nasal drop of the present invention

The second affiliated hospital, Guizhou university of TCM Pharmaceutical Department Drug Manufacturing Room, every 10ml.Lot number: 20081201

2.2 1% nitrofurazone and ephedrine nasal drops:

The upper good Huangpu pharmaceutical Co. Ltd production of sea-freight, every 10ml.Lot number national drug standard: H31022695.

3. administrated method:

3.1 treatment groups: after advising patient to blow net nasal secretion, giving agent collunarium of the present invention, every time 2 drop, 3 times a day, treatment 7 It is discontinued after it.Clinical symptoms, sign are recorded in 7 days front and backs for the treatment of and after being discontinued 14 days respectively.

3.2 control groups: after advising patient to blow net nasal secretion, 1% nitrofurazone and ephedrine nasal drops collunarium is given: 2 drop every time, 3 times a day, Treatment is discontinued after 7 days.Clinical symptoms, sign are recorded in 7 days front and backs for the treatment of and after being discontinued 14 days respectively.

Three, observation of curative effect

3.1 efficacy determination foundations:

Symptom, the sign of clinical observation carry out quantization and integrate following [8]:

Nasal obstruction: without nasal obstruction (0 point)；Intermittence nasal obstruction (2 points)；The nasal continuous time is long (4 points)；Lasting nasal obstruction, dehisces to exhale It inhales (6 points).

Runny nose: without runny nose (0 point)；Mostly glutinous purulence tears, blow tears < 5 times/day (2 points)；5~10 times/day of tears are blown, tears amount is more, Mostly purulence tears (4 points)；Tears > 10 times/day are blown, yellow purulence tears continue (6 points).

Headache: no headache (0 point)；Slight headache (2 points)；It has a headache obvious (4 points)；Headache is unbearably (6 points).

Nasal decongestion swelling: middle concha nasalis inferior is without congested enlargement (0 point)；Middle concha nasalis inferior mild hyperaemia enlargement, nasal meatus interval 1 ~2mm (2 points)；The obviously congested enlargement of middle concha nasalis inferior, nasal meatus gap < 1mm (4 points)；The seriously congested enlargement of middle concha nasalis inferior, nasal meatus without Gap (6 points).

3.2 efficacy determination methods:

Clinical efficacy determines following [8]:

Post treatment integral slip=(pre-treatment score-post treatment integral)/pre-treatment score × 100%.

Recovery from illness: symptom and sign disappears, and integrates slip >=95%；

Effective: symptom and sign is obviously improved, and integrates slip >=30%；

Invalid: symptom and sign mitigates or without substantially reduced, integral slip < 30%.

3.3 efficacy determination times:

Symptom and sign carries out integral calculation according to symptom and sign quantization table before two groups of treatments, and treatment continues observation simultaneously after 7 days Clinical efficacy judgement is carried out according to above-mentioned judgment basis；Clinical efficacy judgement is carried out again after being discontinued 14 days, and by the data obtained Carry out statistical procedures.

The inspection of 3.4 blood serum IL-6s:

Patients serum's interleukin-6 content is responsible for inspection by clinical laboratory, the second affiliated hospital, Guizhou university of TCM, used Reagent is human interleukin-6 (IL-6) radioimmunoassay kitss provided by nine ancient cooking vessel Biotechnology Co., Ltd of Tianjin, normal to join Examine value are as follows: 30.82-131.74pg/ml.Blood drawing measurement observation is carried out in two groups of treatments, 7 days front and backs respectively.And by data information into Row statistical procedures.

4.3 statistical dispositions: all measurement datas are all made of SPSS17.0 statistical software and are handled.

Four, result of study

This research totally 120, treatment group 60 has no adverse reaction and medication malaise symptoms by clinical observation.Control Group 60, having 29 to tell occasionally after medication has mycteroxerosis uncomfortable.By clinical observation, this test result chart is as follows:

Symptom and sign integrates statistical conditions after table 1. is treated 7 days:

Note: with P=9.79 > 0.05 control group ratio " △ ", P=0.751 > 0.05 " △ △ ".Ratio before the treatment of " * " and treatment group P=0.00 < 0.05, than P=0.00 < 0.05 before the treatment of " * * " and control group.

Symptom and sign integrates statistical conditions after table 2. is discontinued 14 days:

Note: compare with before treatment: P=0.00 < 0.05 " △ ", P=0.00 < 0.05 " * * "." * " P=compared with the control group 0.029<0.05。

Clinical efficacy after the treatment of table 3. 7 days:

Note: P=0.589 < 0.05 compared with the control group " * ".

Clinical efficacy after the drug withdrawal of table 4. after 14 days:

Note: P=0.037 < 0.05 compared with the control group " * ".

5. interleukin-6 of table (IL-6), two groups of pretherapy and post-treatment variations

Note: compared with the control group: p=0.749>0.05 " * ", p=0.00<0.05 " △ ".Ratio before being treated with control group: " △ △ ": p=0.00 < 0.05, ratio before the treatment of " * * " and treatment group: p=0.00 < 0.05.

Five, efficacy analysis:

Table 1: the quantization integral of symptom and sign is comparable (P > 0.05) before patient treats.After treatment 7 days, treatment group Symptom integral 4.733 ± 3.844, control group symptom integral 5.133 ± 4.204, under two groups of symptom integrals are obvious before relatively treating Drop, after being statistically analyzed, the integral after two groups of treatments has significant difference (P < 0.05) compared with pre-treatment, two after treatment But there was no significant difference (P > 0.05) for integral between group, and two groups of drugs are effective after illustrating treatment 7 days, but the treatment between two groups of drugs Imitate no significant difference.

Table 2: two groups of integrals decline after being discontinued 14 days, and after being statistically analyzed, two groups have conspicuousness poor before and after treatment Different (P < 0.05), and comparison among groups also have significant difference (P < 0.05).Illustrate after being discontinued 14 days, agent nose dropping treatment of the present invention is anxious Property nose-nasosinusitis effect be better than 1% nitrofurazone and ephedrine nasal drops.

Table 3, table 4 are the judgements about clinical efficacy, and the total effective rate of 7 Tian Hou treatment groups for the treatment of is 90%, control group Total effective rate 88.33%, two groups of data are statistically analyzed, and there was no significant difference (P > 0.05), the clinical treatment after being discontinued 14 days Effect determines, is 81.67% through statistics treatment group's total effective rate, and control group total effective rate is 63.33%, is statistically analyzed, and has Have significant difference (P < 0.05), consistent with symptom integral to illustrate: two kinds of drug therapy acute sinusitis have in acute stage Certain effect, but the observation after drug withdrawal shows that the effect of agent collunarium of the present invention is better than 1% nitrofurazone and ephedrine nasal drops.

Table 5 is visible: the blood serum IL-6 content difference for being included in 120 acute sinusitis patients of this Germicidal efficacy is equal Higher than normal value, the content for treating preceding two groups of IL-6, which is statistically analyzed, is comparable (P > 0.05).Respectively by the present invention After agent collunarium and 1% nitrofurazone and ephedrine nasal drops are treated 7 days, treatment group's IL-6 content drops to 110.22 ± 16.94pg/ml, control group Blood serum IL-6 content drops to 125.46 ± 14.59pg/ml.After being statistically analyzed: the blood serum IL-6 between two groups after treatment Content has significant difference (P < 0.05), because treatment group's decline is slightly obvious compared with control group decline, therefore can illustrate agent of the present invention Collunarium is better than 1% nitrofurazone and ephedrine nasal drops to the effect for reducing this inflammatory factor of blood serum IL-6.

IL-6 is a kind of typically with the cell factor of multiple biological function, is primarily involved in Cellular Immunity, inflammation The activities such as disease reaction, hematopoietic regulation [9].IL-6 not only can inducing inflammatory reaction, and have anti-inflammatory effect.The former can induce carefully Adhesion molecule and chemotactic neutrophil leucocyte intracellular is to generate inflammatory reaction；The latter can in inflammatory cytokine IL-1 β, The factors such as TNF-α generate certain inhibiting effect [10].A kind of diseases associated with inflammation of the acute sinusitis as acute attack, Inflammatory reaction can equally be caused, activate anticusp inflammation factor IL-6.When schneiderian membrance is by bacterium, virus attack, due to part point The reduction for secreting type immunoglobulin level causes the Scavenging activity of local mucous membrane to reduce, and transports intracorporal cell factor by blood Defeated each position to body wherein also including IL-6, therefore leads to the raising of blood serum IL-6 content.It, can be with according to this relationship If speculating the inflammation of control body, so that it may the content of the inflammatory factor in corresponding control serum, wherein also including IL-6.Therefore Observe the content of IL-6 in the pretherapy and post-treatment serum of acute sinusitis patient, so that it may prove agent collunarium of the present invention to drop Low IL-6 content tool has certain effect.

By this test, it can be deduced that such as draw a conclusion: the quantization integral of the pretherapy and post-treatment symptom and sign of patient and clinical treatment Effect shows that the short term efficacy of agent collunarium and 1% nitrofurazone and ephedrine nasal drops treatment acute sinusitis of the present invention is significant, but the treatment of two medicines Effect is without significant difference (P > 0.05).But the effect of agent collunarium of the present invention is better than 1% nitrofurazone and ephedrine nasal drops (P < 0.05) after being discontinued 14 days. And the changes of contents of blood serum IL-6 is shown, two groups of drugs have an impact to the content of inflammatory factor IL-6, and agent collunarium of the present invention 1% nitrofurazone and ephedrine nasal drops are better than to the effect for reducing this inflammatory factor of blood serum IL-6.

The short term efficacy of agent nose dropping treatment acute sinusitis of the present invention is the same with 1% nitrofurazone and ephedrine nasal drops, can have rapidly Reduction of patient malaise symptoms are imitated, while its curative effect after being discontinued 14 days is much higher than 1% nitrofurazone and ephedrine nasal drops treatment group.By observing blood The variation of clear Il-6 content, researches show that two medicines the anti-inflammatory effect of obstructed degree, but the anti-inflammatory effect of agent collunarium of the present invention Slightly it is better than the anti-inflammatory effect of 1% nitrofurazone and ephedrine nasal drops.

Found in this research, when control group is treated using 1% nitrofurazone and ephedrine nasal drops, patient tell after drop medicine 2-3 second it is rapid The case where improving nasal airflow, but duration of efficacy is partially about 1-3 hours short, and there are still rhinostegnosis later for drug timeliness, even Symptom is slightly aobvious earlier above to be aggravated, and some patientss self-induction mycteroxerosis after persistently dripping medicine 4-6 days, nasal cavity endocrine incrustation needs to rinse After nasal cavity can be cleaned out.Treatment group does not occur mycteroxerosis using 60 patients of agent nose dropping treatment of the present invention, in nasal cavity Dry scab situation can equally alleviate nasal airflow situation after dripping medicine in 2-3 seconds, and the duration about 4-6 hours, some patientss existed Visible a large amount of clear water samples or yellow purulence sample secretion outflow after drop medicine about 2-3 minutes, after treatment 3-5 days, nasal cavity endocrine is not See and continue to flow out, some patientss symptom after treatment 4-6 days even disappears completely.It cleans in nasal cavity, is had no in nasal meatus on inspection Dry scab, schneiderian membrane do not occur atrophy situation.

What has been described above is only an embodiment of the present invention, and the common sense such as well known specific structure and characteristic are not made herein in scheme Excessive description.It, without departing from the structure of the invention, can be with it should be pointed out that for those skilled in the art Several modifications and improvements are made, these also should be considered as protection scope of the present invention, these all will not influence what the present invention was implemented Effect and patent practicability.The scope of protection required by this application should be based on the content of the claims, in specification The records such as specific embodiment can be used for explaining the content of claim.

Claims (6)

1. a kind of nasal drop, it is characterised in that: the nasal drop includes the raw material of following weight ratio ingredient: cordate houttuynia 80-100 Part, 80-100 parts of Centipeda minima, 80-100 parts of Glabrous Sarcandra Herb, 80-100 parts of dayflower, 70-90 parts of purslane, achene of Siberian cocklebur 80-90 Part, 100-106 parts of Flos Magnoliae Liliflorae, 70-80 parts of rhizoma acori graminei, 50-60 parts of Chinese ephedra, 0.1-1 parts of borneol.

2. a kind of nasal drop according to claim 1, it is characterised in that: following components are whole by weight, cordate houttuynia 100 Part, 100 parts of Centipeda minima, 90 parts of Glabrous Sarcandra Herb, 80 parts of dayflower, 70 parts of purslane, 85 parts of the achene of Siberian cocklebur, 100 parts of Flos Magnoliae Liliflorae, stone Chang 80 parts of Pu, 50 parts of Chinese ephedra, 1 part of borneol.

3. a kind of nasal drop according to claim 1, it is characterised in that: following components are whole by weight, cordate houttuynia 80 Part, 80 parts of Centipeda minima, 100 parts of Glabrous Sarcandra Herb, 95 parts of dayflower, 80 parts of purslane, 81 parts of the achene of Siberian cocklebur, 106 parts of Flos Magnoliae Liliflorae, stone Chang 80 parts of Pu, 50 parts of Chinese ephedra, 1 part of borneol.

4. a kind of nasal drop according to claim 1, it is characterised in that: following components are whole by weight, cordate houttuynia 100 Part, 80 parts of Centipeda minima, 100 parts of Glabrous Sarcandra Herb, 98 parts of dayflower, 85 parts of purslane, 83 parts of the achene of Siberian cocklebur, 103 parts of Flos Magnoliae Liliflorae, stone Chang 78 parts of Pu, 55 parts of Chinese ephedra, 0.1 part of borneol.

5. a kind of nasal drop according to claim 1, it is characterised in that: following components are whole by weight, cordate houttuynia 90 Part, 90 parts of Centipeda minima, 80 parts of Glabrous Sarcandra Herb, 80 parts of dayflower, 78 parts of purslane, 90 parts of the achene of Siberian cocklebur, 101 parts of Flos Magnoliae Liliflorae, stone Chang 76 parts of Pu, 53 parts of Chinese ephedra, 0.5 part of borneol.

6. a kind of nasal drop according to claim 1, it is characterised in that: following components are whole by weight, cordate houttuynia 80 Part, 85 parts of Centipeda minima, 92 parts of Glabrous Sarcandra Herb, 94 parts of dayflower, 90 parts of purslane, 87 parts of the achene of Siberian cocklebur, 105 parts of Flos Magnoliae Liliflorae, stone Chang 73 parts of Pu, 58 parts of Chinese ephedra, 0.3 part of borneol.