CN110302307A - A kind of enriching yin beauty Mrs's protect liver liquid medicine and preparation method thereof - Google Patents
A kind of enriching yin beauty Mrs's protect liver liquid medicine and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of enriching yin beauty Mrs's protect liver liquid medicine, including following components: clove leaf, cloves, mulberry fruit, lucid asparagus, Rehmannia glutinosa, wilsonii, fructus lycii, jujube and wine.The invention also discloses a kind of preparation methods of enriching yin beauty Mrs's protect liver liquid medicine.A kind of enriching yin beauty Mrs's protect liver liquid medicine provided by the invention and preparation method thereof, the proportion and diacolation process flow for optimizing Ms's medicinal liquor prescription with positive quadraturing design test enable Ms's liquid medicine preferably to play its curative effect to obtain optimal method of production.Using sensory evaluation come clove leaf in optimization of C/C composites, mulberry fruit, lucid asparagus, 4 taste main ingredient of Rehmannia glutinosa proportion, optimize diacolation technique as evaluation index using Thick many candies content, the best process of the final optimum proportioning for obtaining enriching yin beauty Mrs's protect liver liquid medicine composition proportion and diacolation technique.
Description
Technical field
The present invention relates to a kind of enriching yin beauty Mrs's protect liver liquid medicine and preparation method thereof, belong to technical field of traditional Chinese medicines.
Background technique
According to the traditional traditional Chinese medical theory in China, wine has the length one of hundred medicines to say, can reasonable employment can preferably increase
Add Chinese Herbs.Liquid medicine has had thousands of years of history in China, is the very important constituent of chinese medicine science.
Nowadays social, as China's economic level constantly develops, the continuous improvement of Living consumption and society's warp
The variation of Ji, living environment, the mankind are in concept of health and pursue and have and greatly enhance in the consciousness of life quality, face work
How indispensable wine table culture, realize in not wound body or few wound body in the fierceness of reinforcing, the competition of efficiency, workplace
The case where get off to relieve stress and carry out social dinner party, be a problem of current urgent need to resolve.
Summary of the invention
The technical problem to be solved by the present invention is in view of the above-mentioned problems existing in the prior art, provide a kind of enriching yin beauty
Hold Mrs protect liver liquid medicine, in place of overcome the deficiencies in the prior art.
Meanwhile the present invention provides a kind of preparation method of enriching yin beauty Mrs's protect liver liquid medicine, the liquid medicine of method preparation, prescription
Match scientific and reasonable, operating method is easy, be as a result easy to arrange, and the diacolation process results after optimizing are reliable and stable, can for into
One step develops Ms's liquid medicine and provides important evidence.
In order to solve the above technical problems, the technical solution adopted by the present invention are as follows:
A kind of enriching yin beauty Mrs's protect liver liquid medicine, including following components: clove leaf, cloves, mulberry fruit, lucid asparagus, Rehmannia glutinosa,
Wilsonii, fructus lycii, jujube and wine.
A kind of enriching yin beauty Mrs's protect liver liquid medicine, comprises the following components in parts by weight: 0.2~0.4 part of clove leaf, cloves
2.5~5 parts, 5~6 parts of mulberry fruit, 5~6 parts of lucid asparagus, 2.5~5 parts of Rehmannia glutinosa, 2.5~5 parts of wilsonii, 2.5~5 parts of fructus lycii,
5~10 parts and 400~600 portions wine of jujube.
A kind of enriching yin beauty Mrs's protect liver liquid medicine, including following components: clove leaf 0.2g, cloves 2.5g, mulberry fruit 5g, Tianmen
Winter 5g, Rehmannia glutinosa 2.5g, wilsonii 2.5g, fructus lycii 2.5g, jujube 5g and 500mL wine, said ratio can increase in proportion to add deduct
It is few.
The wine is 50~55 ° of white wine.
A kind of preparation method of enriching yin beauty Mrs's protect liver liquid medicine, comprising the following steps:
Step 1: appropriate clove leaf, cloves, mulberry fruit, lucid asparagus, Rehmannia glutinosa, wilsonii, fructus lycii and jujube are taken, respectively powder
20~60 mesh are broken to, medicinal material mixture is obtained, it is spare；
Step 2: being divided into two parts for wine, spare；
Step 3: medicinal material mixture spare in step 1 is put into container, and a part of wine in step 2 is added will
Medicinal material mixture is impregnated at least 24 hours, expands medicinal material mixture sufficiently, expansion medicine is made；
Step 4: absorbent cotton is put into after being moistened in the container in step 3, is layered on the bottom of percolator；
Step 5: the expansion medicine in step 3 is placed on to the top of wet rear absorbent cotton, puts filter at the top of expansion medicine
Paper or gauze place weight at the top of filter paper or gauze；
Step 6: the piston of percolator lower end outlet is closed, another part wine in step 2 is slowly added to percolator
Top, covered and enclosed for a period of time after, open the piston of percolator lower end outlet, keep percolate slow with 0.8~1ml/min flow velocity
Slow seepage flow；
Step 7: percolate described in collection step six is slowly added to rock sugar after collecting to percolate and stirs,
It is completely dissolved rock sugar, liquid medicine semi-finished product are made；
Step 8: staticly settling in the phase in liquid medicine semi-finished product, and clarifying agent is added, after staticly settling at least 20 days, filtering；
Step 9: through filter-cloth filtering and collecting filtrate for the made liquid medicine semi-finished product of step 8, and filter cloth mesh number is 120~150
Mesh；
Step 10: by required bottle after sterilizing, Ms's liquid medicine made in step 9 is fitted into and completes to fill in bottle
Dress.
Step 8 can be replaced by low temperature impurity removal method.
The step of low temperature impurity removal method are as follows: the liquid medicine semi-finished product after staticly settling are set in freezing equipment, to liquid medicine half
When finished product temperature is down to -15 DEG C, stop cooling, take out liquid medicine semi-finished product, then temperature is allowed to go up naturally to 5 DEG C, filters.
The clarifying agent is the diatomite for being equivalent to the medicinal material mixture weight 0.05~0.1%.
The clarifying agent includes protein flocculant, amphoteric polyacrylamide flocculant and 101 fruit juice clarifiers, described
The dosage of clarifying agent is be equivalent to the medicinal material mixture weight 0.03~0.05%.
The ratio of the protein flocculant, amphoteric polyacrylamide flocculant and 101 fruit juice clarifiers is 2:1:2.
In the present invention, mulberry fruit, clove leaf, cloves have effects that liver-protecting sobering up poison；Lucid asparagus, Rehmannia glutinosa have enriching yin beauty
The effect of appearance；Jujube, fructus lycii have effects that anti-aging, oxidation resistant；Wilsonii, which has effects that improve, sleeps, and the present invention is main
Demand according to women develops this enriching yin beauty Mrs's protect liver liquid medicine.
Clove leaf is cold in nature, bitter taste, can protect liver, have long history in terms of hepatopathy is treated in China, often in acute jaundice
There is good therapeutic effect in the diseases such as type hepatitis.Active constituent rich in clove leaf, Zhao Changwei etc. is by APAP
Inducing mouse acute hepatic injury model is evaluated with serum transaminase (ALT, AST) active variation.Experimental result is shown
ALT, AST are substantially reduced, so that it is determined that the flavones in clove leaf has the function of liver protection.
Mulberry fruit is sweet in flavor, cold in nature, and tool promotes the production of body fluid to quench thirst, tonifying liver, kidney-nourishing, nourishing yin and supplementing blood, dark hair, sobers up, improving eyesight and quiet nerves, sharp joint
And other effects, there is the title of " civil sage fruit ".The researchs such as Yin Aiwu are in mouse to acute and chronic mouse alcoholism by mulberry polysaccharide
It is carried out in liver, conclusion knows that the active SOD of antioxidase in mulberry polysaccharide increases, and the consumption of GSH is reduced in hepatic tissue, rouge
Matter peroxidating is reduced, to can be used for the exploitation of relieving alcoholism and protecting liver drug to reach liver protective effect.
It is browsed in the ancient books and records of " abide by raw eight writing paper " and learns and take lucid asparagus 1000g, Rehmannia glutinosa 500g smashes Luo Weimo, refined honey
For ball, under heat wine tune, can strong marrow, stay appearance, macrobiosis is made light of one's life by commiting suicide.Compatibility jujube and fructus lycii, jujube are a kind of original spies in China
Some fruits, archaism have: " three jujubes on the one, 70 bear one's age well " can illustrate that jujube has anti-oxidant, anti-aging function, remove
Furthermore jujube also has certain medical functions, the effect of if any invigorating heart moistening lung, blood-enriching face-nourishing and spleen stomach invigorating, nourishing generate fluid etc..
Polysaccharide in jujube is also very important active constituent, the third aging by the way that mouse to be made to glycometabolism of Miao Ming
After model, the pharmacological research progress that comparison gavages high and low dose date polysaccharide group is obtained a result, and date polysaccharide can inhibit to decline
The atrophy of old model mice immune organ and the aging for delaying brain tissue, so jujube has liver protection, improves immunity, antioxygen
The effects of change, anti-aging.
Fructus lycii is a kind of rare medicinal herbs, and the medicinal material of traditional dietotherapeutic, nutritional ingredient rich in have nourishing the liver
Improving eyesight, blood-enriching tranquillizing, tonifying kidney and benefiting sperm, the function of moistening lung to arrest cough, promoting the production of body fluid to quench thirst, promote longevity, meanwhile, in recent years, also always
It is faced by dietotherapy expert and Medical Technologist.Polysaccharides in fructus lycii also has certain effect, and Meng Jiao et al. probes into fructus lycii
Polysaccharide has the effects that immunological regulation, antitumor, anti-oxidant, anti-aging, hypoglycemic, reducing blood lipid, liver protection.
Wilsonii also known as slender acanthopanax ginseng, have long edible history, are the raw materials of new type functional food.Wilsonii contains
There is rich in nutrients, there are the microelements such as flavonoids, sugar, vitamin C, vitamin B2, calcium, sodium, iron and zinc, manganese.According to phase
Central Shanxi Plain medicine books are recorded, and wilsonii can effectively improve human body immune function, while can delay relieving fatigue, Central nervous system
The effects of system and cardiovascular system play adjusting.He etc. is sticked into because wilsonii has the function of that improvement sleep has developed one kind and has
The new health care product acanthopanax fruit oral solution of sedative-hypnotic effect.
Side's solution of the invention: mulberry fruit and lucid asparagus are monarch drug in a prescription in side, and mulberry fruit nourishing yin and supplementing blood promotes the production of body fluid, ease constipation, lucid asparagus yin-nourishing
It moisturizes, relieves inflammation or internal heat, promote the production of body fluid, Papillary is mended without dry.Minister is with Rehmannia glutinosa beneficial to spirit and marrow, strong marrow, and cloves middle benefit gas drop is inverse, cold dispelling stops
Bitterly, warming kidney and enhancing yang, wilsonii wind-damp dispelling, nourishing liver and kidney, strengthening the bones and muscles, tranquilizing the mind.Clove leaf bitter is cold in nature, there is that clearing heat and detoxicating, liver protection is sharp
The function of gallbladder removing jaundice, can relieving alcoholism, fructus lycii nourishing liver and kidney, improving eyesight, jujube tonifying middle-Jiao and Qi, regulating spleen and stomach is altogether assistant to help qi and blood biochemical
Make medicine.All medicines share, the effect of playing nourishing yin and supplementing blood, warming spleen and stomach for dispelling cold, relieving alcoholism altogether.
The invention has the following advantages:
Enriching yin beauty Mrs's protect liver liquid medicine that the present invention develops, mouthfeel, effect are all good.The present invention is tried with orthogonal design
It tests to optimize the proportion of Ms's medicinal liquor prescription and diacolation process flow.To obtain optimal method of production, enable Ms's liquid medicine
Preferably play its curative effect.Using sensory evaluation (in terms of flavour, color, fragrance, clarification degree four) come fourth in optimization of C/C composites
Spiceleaf, mulberry fruit, lucid asparagus, 4 taste main ingredient of Rehmannia glutinosa proportion, optimize diacolation work as evaluation index using Thick many candies content
Skill, 3 soaking time before the crushing mesh number of investigation medicinal material, diacolation, diacolation flow velocity factors are to Thick many candies in Ms's liquid medicine respectively
The influence of content.The optimum proportioning of enriching yin beauty Mrs's protect liver liquid medicine composition proportion: A3B3C1D2, i.e. mulberry fruit 10g, lucid asparagus
10g, Rehmannia glutinosa 5g, clove leaf 0.4g, mulberry fruit, clove leaf have conspicuousness.The optimum condition of diacolation technique: A2B2C1, i.e. medicinal material
Crush mesh number select 40 mesh, before diacolation soaking time selection for 24 hours, diacolation flow velocity select 0.8mL/min, diacolation flow velocity has significant
Property.Under the optimization diacolation process conditions, Thick many candies content is 2152.0mg/L.The content of sensory evaluation and measurement Thick many candies is made
To develop index, more single index screening is more reasonable, scientific, and easy in operating method, is as a result also easy to arrange,
And the diacolation process results after optimizing are reliable and stable, can provide important evidence for further Mrs's exploitation liquid medicine.
Detailed description of the invention
Fig. 1 is the canonical plotting of reference substance glucose of the invention.
Specific embodiment
In order to be more clear the objectives, technical solutions, and advantages of the present invention, with reference to the accompanying drawings and embodiments to this hair
It is bright to be further elaborated.Described herein specific examples are only used to explain the present invention, is not used to limit this hair
It is bright.
Embodiment 1:
A kind of enriching yin beauty Mrs's protect liver liquid medicine, clove leaf 0.4g, cloves 5g, mulberry fruit 10g, lucid asparagus 10g, Rehmannia glutinosa
5g, wilsonii 5g, fructus lycii 5g, jujube 10g and 1000mL52 ° of white wine.
A kind of preparation method of enriching yin beauty Mrs's protect liver liquid medicine, comprising the following steps:
Step 1: taking clove leaf, cloves, mulberry fruit, lucid asparagus, Rehmannia glutinosa, wilsonii, fructus lycii and the jujube of said ratio,
It is crushed to 40 mesh respectively, obtains medicinal material mixture, it is spare；
Step 2: wine is divided into two parts, every part is 500mL, spare；
Step 3: medicinal material mixture spare in step 1 is put into container, and a part of wine in step 2 is added will
Medicinal material mixture is impregnated 24 hours, expands medicinal material mixture sufficiently, expansion medicine is made；
Step 4: absorbent cotton is put into after being moistened in the container in step 3, is layered on the bottom of percolator；
Step 5: the expansion medicine in step 3 is placed on to the top of wet rear absorbent cotton, puts filter at the top of expansion medicine
Paper or gauze place weight at the top of filter paper or gauze；
Step 6: the piston of percolator lower end outlet is closed, another part wine in step 2 is slowly added to percolator
Top, covered and enclosed for a period of time after, open percolator lower end outlet piston, keep percolate slow with 0.8ml/min flow velocity
Seepage flow；
Step 7: percolate described in collection step six is slowly added to rock sugar after collecting to percolate and stirs,
It is completely dissolved rock sugar, liquid medicine semi-finished product are made；
Step 8: staticly settling in the phase in liquid medicine semi-finished product, and the diatom for being equivalent to medicinal material mixture weight 0.05% is added
Soil, after staticly settling 20 days, filtering；
Step 9: through filter-cloth filtering and collecting filtrate for the made liquid medicine semi-finished product of step 8, and filter cloth mesh number is 120 mesh；
Step 10: by required bottle after sterilizing, Ms's liquid medicine made in step 9 is fitted into and completes to fill in bottle
Dress.
The formula to Ms's liquid medicine of the present embodiment and preparation method carry out process optimization experiment below.
1. testing medicinal material and reagent
1.1 experiment medicinal materials
Table 1 tests medicinal material used
1.2 experiment reagent
2 experiment reagent of table
1.3 experimental facilities
3 laboratory apparatus of table
2. organoleptic indicator's evaluation method
Enriching yin beauty protect liver lady wine, sensory evaluation criteria packet are formulated in the sensory evaluation of 4 Orthogonal Experiment and Design of reference table
Color, fragrance, clarification degree, flavour are included to be tasted, the Ms between 20-40 years old forms sensory evaluation by 10 ages
Group, they carry out sensory evaluation scores to the wine sample of the enriching yin beauty protect liver lady wine of different disposal, seek average mark.Specific scoring
Standard is referring to table 4.
4 enriching yin beauty protect liver lady wine evaluation criterion of table
The orthogonal test of 2.1 Ms's liquid medicine sense organs
Design [L16(45)] orthogonal test seeks best enriching yin beauty Mrs's protect liver medicinal liquor prescription, factor level is shown in Table 5.
Using 4 factor, 4 level [L16(45)] orthogonal test method, using color, fragrance, flavour, degree is clarified as enriching yin beauty protect liver
The organoleptic indicator of Ms's liquid medicine, determine main Chinese medicinal materials clove leaf, mulberry fruit, lucid asparagus, Rehmannia glutinosa proportion.
The experimental factor and level of 5 Ms's liquid medicine of table proportion
3. diacolation process flow method
Cloves, clove leaf, mulberry fruit, Rehmannia glutinosa, lucid asparagus, wilsonii, jujube, 8 taste medicinal material of fructus lycii are all ground into a fixed number
Mesh；The white wine that the above 8 taste medicinal materials addition 1000mL alcoholic strength is 52%vol, which is weighed, by accurate weight proportion carries out diacolation.By medicine
Material is crushed with high speed medicinal herb grinder, and medicinal material is mixed and is immersed in 500mL white wine, and impregnating 6h makes medicinal material become expansion medicine, is had
Conducive to the progress of diacolation technique.It is excessively not de- with glass bar to percolate pot central draft in the absorbent cotton that percolate pot is added to wetting
After rouge cotton, glass bar adherent can be drained.500mL white wine is added, seals with sealing film and is impregnated before carrying out diacolation.After impregnating well
Diacolation picks up percolate with the beaker of wash clean.
3.1. diacolation process optimization Orthogonal Experiment and Design
It can be obtained by experience, influence many because being known as of enriching yin beauty Mrs's protect liver liquid medicine development, in addition to sensory evaluation, also
Have before diacolation that factors, the Variable Factors such as soaking time, diacolation flow velocity are respectively A, B, C, each factor before pulverizing medicinal materials mesh number, diacolation
Three levels are taken, using [L9(34)] influence of the orthogonal test to Thick many candies content in enriching yin beauty Mrs's protect liver liquid medicine grind
Study carefully, tests the factor and level referring to table 6.
6 enriching yin beauty Mrs's protect liver liquid medicine diacolation technique quadrature factor of table is horizontal
Investigation to pulverizing medicinal materials mesh number: soaking time and diacolation flow velocity are certain before diacolation, and pulverizing medicinal materials mesh number difference is surveyed
Its absorbance；Pulverizing medicinal materials mesh number is 20 mesh, 40 mesh, 60 mesh respectively.
Investigation to soaking time before diacolation: pulverizing medicinal materials mesh number and diacolation flow velocity are certain, and soaking time is different before diacolation
Survey its absorbance；Before diacolation soaking time be respectively 12h, for 24 hours, 36h.
Investigation to diacolation flow velocity: the immersion infiltration time is certain before pulverizing medicinal materials mesh number and diacolation, and diacolation flow velocity difference surveys it
Absorbance；Diacolation flow velocity is 0.8mL/min, 1.2mL/min, 1.6mL/min respectively.
And Orthogonal experiment results are verified.
3.2. Thick many candies assay
The preparation of sample Thick many candies precipitating: it is accurate to draw diacolation sample solution 5.00mL, it is placed in 50mL centrifuge tube, is added
20.00mL dehydrated alcohol mixes, and is placed on standing 4h or more in 4 DEG C of refrigerators, is centrifuged 10min with 4000r/min, discards supernatant liquid,
Residue is that 80% ethanol solution washs with volume fraction, and liquid is discarded supernatant after centrifugation, is operated 3 times repeatedly.Remaining residue water
It dissolves and is settled to 100mL.As gained sample, it is spare.
Glucose standard curve draw: accurately draw glucose standards solution (2.5g/L) 0.10ml, 0.20mL,
0.40mL, 0.60mL, 0.80mL, 1.00mL are respectively placed in 6 25mL colorimetric cylinders, and having marked test tube number is 1~6, are mended respectively
Water is detected, distilled water is blank control group to 2.00mL with phend-sulphuric acid.5% phenol solution 1.00mL is added, is added
Sulfuric acid 10.00mL will carefully shake up rapidly in the process, until it is cooling, in the static 5min postposition boiling water bath of room temperature
Then 2.00min is cooled to room temperature, its absorbance value is measured at 490nm wavelength.2.0ml is added as blank group in test tube 7
Distilled water, 1ml phenol liquid, 10ml concentrated sulfuric acid mixed liquor are done by aforesaid operations.
The measurement of sample: precision measures test solution 0.1mL, adds water 1.9mL, according to measurement glucose standard curve
Method operation, measures absorbance value, from the concentration for finding out glucose in test solution in regression equation.It calculates as follows
Thick many candies content in sample.
Thick many candies content (%)=C × D × f × 100/W
C --- the concentration (mg/mL) of glucose in test solution
The dilution factor of D --- test liquid
F --- conversion factor
W --- test sample weight (g)
3.3. glucose standard curve regression equation
With glucose mass concentration (X) for abscissa, absorbance value (Y) is ordinate, draws glucose standard curve, obtains
Equation of linear regression is Y=0.0414X+0.0007, R2=0.9956, regression equation is referring to Fig. 1.
4. component proportion sense organ orthogonal experiments are analyzed
Concrete outcome is shown in Table 7~table 8.
7 different component of table matches enriching yin beauty Mrs protect liver liquid medicine sensory evaluation orthogonal arrage
8 different component of table matches enriching yin beauty Mrs protect liver liquid medicine sensory evaluation variance analysis
Note: P value has conspicuousness less than 0.05.
As known from Table 7, each factor influences experimental result to be A > D > B > C, i.e. mulberry fruit > clove leaf > lucid asparagus > Rehmannia glutinosa,
Referring to table 8 it is found that mulberry fruit, clove leaf have conspicuousness during sensory evaluation.Finally select A3B3C1D2, i.e. mulberry fruit 10g,
Lucid asparagus 10g, Rehmannia glutinosa 5g, clove leaf 0.4g are optimum formula, and mouthfeel is best.
5. diacolation process optimization orthogonal experiments are analyzed
Concrete outcome is shown in Table 9~table 11.
The analysis of 9 enriching yin beauty Mrs's protect liver liquid medicine diacolation technique orthogonal experiments of table
10 enriching yin beauty Mrs's protect liver liquid medicine diacolation technique variance analysis of table
Note: P value has conspicuousness less than 0.05.
As shown in Table 9, soaking time before influence C > A > B of each factor to experimental result, that is, diacolation flow velocity > diacolation >
Pulverizing medicinal materials mesh number.
As shown in Table 10, diacolation flow velocity has conspicuousness.Finally select A2B2C1For best diacolation technique, i.e. pulverizing medicinal materials
Mesh number selects soaking time before 40 mesh, diacolation flow velocity selection 0.8mL/min, diacolation to select for 24 hours.
11 diacolation process certification result of table
Interpretation of result: as shown in Table 11, using medicinal material amount identical with orthogonal processing, pulverizing medicinal materials mesh number select 40 mesh,
For 24 hours, parallel test 3 times, Thick many candies content at this time is more steady for soaking time selection before diacolation flow velocity selects 0.8mL/min, diacolation
It is set to 2152.0mg/L, shows that orthogonal processing is feasible.
6. the effect experiment of enriching yin beauty Mrs's protect liver liquid medicine
6.1. it is grouped stomach-filling
Clean grade mouse divides three groups at random, every group 8, respectively blank control group, ancient prescription beauty liquid medicine stomach-filling group, this reality
Apply Ms's liquid medicine stomach-filling group of example.Wherein ancient prescription beauty liquid medicine is identical as Ms's liquid medicine alcoholic strength of the present embodiment, is 52 °,
Dosage is the same, and (dosage according to mouse weight 13ml/kg), and blank control group gives the water of same dose, holds once a day
It is 15 days continuous.After experiment last day each group mouse is deprived of food but not water 12h, weighing takes blood, centrifugation (3500r/min, 10min) point
From preparing serum.
Wherein, the Fang Yuanwei " Chinese medicine report " of ancient prescription beauty liquid medicine.
The composition of ancient prescription beauty liquid medicine are as follows: ginseng 15g (or ginseng palpus), fructus alpiniae oxyphyllae 15g, RADIX ANGELICAE SINEINSIS 20g, radix polygonati officinalis 20g, Tianmen
Winter 20g, tuber of dwarf lilyturf 20g, fructus schisandrae 20g process rhizoma polygonati 30g, RADIX POLYGONI MULTIFLORI PREPARATA 30g, fructus lycii 30g, big Radix Rehmanniae 30g.
Its preparation usage are as follows: by medicine-feeding altogether to be thick last, gauze bag storage dress is soaked in bottle with 2500 milliliters of white wine, then plus
Enter white sugar 250g, impregnates more than 10 days.Dinner respectively takes 20~30 milliliters in daily, can also suitably be increased and decreased according to capacity for liquor.Long term usage.
Its effect: it preserves youthful looks.
6.2. the detection of hepatic injury index ALT and AST
Serum obtained is taken to detect glutamic-pyruvic transaminase (ALT) by kit operating instruction, the water of glutamic-oxalacetic transaminease (AST)
It is flat.Testing result is shown in Table 12.
Three groups of mice serum ALT, AST changes of contents results of the measurement of table 12 (N=8)
6.3. result
Referring to AST, ALT value of blank control group, discovery give in the experimental animal serum of ancient prescription beauty liquid medicine AST and
It is horizontal slowly that the horizontal significant Ms's liquid medicine group for increasing, and giving same dose of ALT increases AST and ALT.Hepatocellular injury can draw
The raising of serum alt and AST level is played, but Ms's liquid medicine of the present embodiment increases slowly compared with ancient prescription beauty liquid medicine, illustrates this
Ms's liquid medicine of embodiment is smaller to hepar damnification.
6.4. liquid medicine functional observation is tested
Comparative experimental study, the symptom after observing Ms's liquid medicine of women ancient prescription beauty liquid medicine and the present embodiment are anti-
It answers, the women of observation is in symptom, the same or similar situation of constitution.Two kinds of wine of 200mL are drunk by several times, next day observes the symptoms instead
It answers, see the table below 13.
Table 13 takes the symptomatic reaction table of ancient prescription beauty liquid medicine and Ms's liquid medicine
6.5. the Ms's liquid medicine for taking the present embodiment daily is primary, each 50ml, a month as a treatment course.Take front and back
Symptomatic reaction is compared, effect is obvious, see the table below 14.
The symptomatic reaction table of the Mrs's long-term use liquid medicine of table 14
In conclusion Ms's liquid medicine of the present embodiment has effects that good enriching yin beauty protect liver.
The present embodiment optimizes the proportion and diacolation process flow of Ms's medicinal liquor prescription with positive quadraturing design test.To obtain
Optimal method of production enables Ms's liquid medicine preferably to play its curative effect.Using sensory evaluation come clove leaf in optimization of C/C composites,
Mulberry fruit, lucid asparagus, 4 taste main ingredient of Rehmannia glutinosa proportion, optimize diacolation technique as evaluation index using Thick many candies content, respectively
The shadow of 3 soaking time, diacolation flow velocity factors before investigating the crushing mesh number of medicinal material, diacolation to Thick many candies content in Ms's liquid medicine
It rings.The optimum proportioning of enriching yin beauty Mrs's protect liver liquid medicine composition proportion: A3B3C1D2, i.e. mulberry fruit 10g, lucid asparagus 10g, Rehmannia glutinosa
5g, clove leaf 0.4g, mulberry fruit, clove leaf have conspicuousness.The optimum condition of diacolation technique: A2B2C1, i.e. pulverizing medicinal materials mesh number choosing
Select before 40 mesh, diacolation soaking time selection for 24 hours, diacolation flow velocity selection 0.8mL/min, diacolation flow velocity has conspicuousness.It is excellent at this
Change under diacolation process conditions, Thick many candies content is 2152.0mg/L.The content of sensory evaluation and measurement Thick many candies refers to as development
Mark, more single index screening is more reasonable, scientific, and easy in operating method, is as a result also easy to arrange, and after optimization
Diacolation process results be also it is reliable and stable, can for further Mrs's exploitation liquid medicine important evidence be provided.
Embodiment 2:
The present embodiment and the difference of embodiment 1 are only that:
A kind of enriching yin beauty Mrs's protect liver liquid medicine, clove leaf 0.4g, cloves 5g, mulberry fruit 10g, lucid asparagus 10g, Rehmannia glutinosa
5g, wilsonii 5g, fructus lycii 5g, jujube 10g and 800mL55 ° of white wine.
A kind of preparation method of enriching yin beauty Mrs's protect liver liquid medicine, comprising the following steps:
Step 1: taking said ratio clove leaf, cloves, mulberry fruit, lucid asparagus, Rehmannia glutinosa, wilsonii, fructus lycii and jujube, point
It is not crushed to 20 mesh, obtains medicinal material mixture, it is spare；
Step 2: wine is divided into two parts, every part is 400mL, spare；
Step 3: medicinal material mixture spare in step 1 is put into container, and a part of wine in step 2 is added will
Medicinal material mixture is impregnated 36 hours, expands medicinal material mixture sufficiently, expansion medicine is made；
Step 4: absorbent cotton is put into after being moistened in the container in step 3, is layered on the bottom of percolator；
Step 5: the expansion medicine in step 3 is placed on to the top of wet rear absorbent cotton, puts filter at the top of expansion medicine
Paper or gauze place weight at the top of filter paper or gauze；
Step 6: the piston of percolator lower end outlet is closed, another part wine in step 2 is slowly added to percolator
Top, covered and enclosed for a period of time after, open percolator lower end outlet piston, seep percolate slowly with 1ml/min flow velocity
Stream；
Step 7: percolate described in collection step six is slowly added to rock sugar after collecting to percolate and stirs,
The additional amount of rock sugar is the 1% of medicinal material mixture weight, is completely dissolved rock sugar, liquid medicine semi-finished product are made；
Step 8: staticly settling in the phase in liquid medicine semi-finished product, and the silicon for being equivalent to the medicinal material mixture weight 0.1% is added
Diatomaceous earth, after staticly settling 30 days, filtering；
Step 9: through filter-cloth filtering and collecting filtrate for the made liquid medicine semi-finished product of step 8, and filter cloth mesh number is 120 mesh；
Step 10: by required bottle after sterilizing, Ms's liquid medicine made in step 9 is fitted into and completes to fill in bottle
Dress.
Embodiment 3:
The present embodiment and the difference of embodiment 1 are only that:
A kind of enriching yin beauty Mrs's protect liver liquid medicine, clove leaf 0.8g, cloves 10g, mulberry fruit 12g, lucid asparagus 12g, Rehmannia glutinosa
10g, wilsonii 10g, fructus lycii 10g, jujube 20g and 1200mL55 ° of white wine.
A kind of preparation method of enriching yin beauty Mrs's protect liver liquid medicine, comprising the following steps:
Step 1: taking clove leaf, cloves, mulberry fruit, lucid asparagus, Rehmannia glutinosa, wilsonii, fructus lycii and the jujube of said ratio,
It is crushed to 60 mesh respectively, obtains medicinal material mixture, it is spare；
Step 2: wine is divided into two parts, every part is 600mL, spare；
Step 3: medicinal material mixture spare in step 1 is put into container, and a part of wine in step 2 is added will
Medicinal material mixture is impregnated 30 hours, expands medicinal material mixture sufficiently, expansion medicine is made；
Step 4: absorbent cotton is put into after being moistened in the container in step 3, is layered on the bottom of percolator；
Step 5: the expansion medicine in step 3 is placed on to the top of wet rear absorbent cotton, puts filter at the top of expansion medicine
Paper or gauze place weight at the top of filter paper or gauze；
Step 6: the piston of percolator lower end outlet is closed, another part wine in step 2 is slowly added to percolator
Top, covered and enclosed for a period of time after, open percolator lower end outlet piston, keep percolate slow with 0.9ml/min flow velocity
Seepage flow；
Step 7: percolate described in collection step six is slowly added to rock sugar after collecting to percolate and stirs,
The additional amount of rock sugar is the 1.5% of medicinal material mixture weight, is completely dissolved rock sugar, liquid medicine semi-finished product are made；
Step 8: low temperature removal of impurities, the liquid medicine semi-finished product after staticly settling set in freezing equipment, such as refrigerator, to liquid medicine half
When finished product temperature is down to -15 DEG C, stop cooling, take out liquid medicine semi-finished product, then temperature is allowed to go up naturally to 5 DEG C, filters.
Step 9: through filter-cloth filtering and collecting filtrate for the made liquid medicine semi-finished product of step 8, and filter cloth mesh number is 120 mesh；
Step 10: by required bottle after sterilizing, Ms's liquid medicine made in step 9 is fitted into and completes to fill in bottle
Dress.
Embodiment 4:
The present embodiment and the difference of embodiment 1 are only that: the clarifying agent is protein flocculant, amphoteric polyacrylamide
Amine flocculant and 101 fruit juice clarifiers, the dosage of the clarifying agent are be equivalent to the medicinal material mixture weight 0.03%.
The ratio of the protein flocculant, amphoteric polyacrylamide flocculant and 101 fruit juice clarifiers is 2:1:2.
After substituting diatomite using the clarifying agent of the present embodiment, the clarification degree of Ms's liquid medicine are as follows: glossy, clarification is saturating
It is bright, without obvious suspended matter, sensory evaluation scores 13~15/, and after long-term (at least six moon) is placed, Ms's liquid medicine
Clarification degree remains unchanged, i.e., without Precipitation after long-term placement, remains clarification transition.
Embodiment 5:
The present embodiment and the difference of embodiment 4 are only that: the dosage of clarifying agent is to be equivalent to the medicinal material mixture weight
0.05%
The basic principles, main features and advantages of the present invention have been shown and described above.The technology of the industry
Personnel are it should be appreciated that the present invention is not limited to the above embodiments, and the above embodiments and description only describe this
The principle of invention, without departing from the spirit and scope of the present invention, various changes and improvements may be made to the invention, these changes
Change and improvement all fall within the protetion scope of the claimed invention.The claimed scope of the invention by appended claims and its
Equivalent thereof.
Claims (10)
1. a kind of enriching yin beauty Mrs's protect liver liquid medicine, it is characterised in that: including following components: clove leaf, cloves, mulberry fruit, Tianmen
Winter, Rehmannia glutinosa, wilsonii, fructus lycii, jujube and wine.
2. a kind of enriching yin beauty Mrs's protect liver liquid medicine according to claim 1, it is characterised in that: including following parts by weight
Component: 0.2 ~ 0.4 part of clove leaf, 2.5 ~ 5 parts of cloves, 5 ~ 6 parts of mulberry fruit, 5 ~ 6 parts of lucid asparagus, 2.5 ~ 5 parts of Rehmannia glutinosa, wilsonii
2.5 ~ 5 parts, 5 ~ 10 parts and 400 ~ 600 portions 2.5 ~ 5 parts of fructus lycii, jujube wine.
3. a kind of enriching yin beauty Mrs's protect liver liquid medicine according to claim 1, it is characterised in that: including following components: fourth
Spiceleaf 0.2g, cloves 2.5g, mulberry fruit 5g, lucid asparagus 5g, Rehmannia glutinosa 2.5g, wilsonii 2.5g, fructus lycii 2.5g, jujube 5g and
500mL wine, said ratio can increase or decrease in proportion.
4. a kind of enriching yin beauty Mrs's protect liver liquid medicine according to claim 1, it is characterised in that: the wine is 50 ~ 55 ° white
Wine.
5. a kind of preparation method of enriching yin beauty Mrs's protect liver liquid medicine according to claim 1, it is characterised in that: including with
Lower step:
Step 1: appropriate clove leaf, cloves, mulberry fruit, lucid asparagus, Rehmannia glutinosa, wilsonii, fructus lycii and jujube are taken, is crushed to respectively
20 ~ 60 mesh obtain medicinal material mixture, spare；
Step 2: being divided into two parts for wine, spare；
Step 3: medicinal material mixture spare in step 1 is put into container, and a part of wine is added in step 2 by medicinal material
Mixture impregnates at least 24 hours, expands medicinal material mixture sufficiently, expansion medicine is made；
Step 4: absorbent cotton is put into after being moistened in the container in step 3, is layered on the bottom of percolator；
Step 5: by the expansion medicine in step 3 be placed on it is wet after absorbent cotton top, put at the top of expansion medicine filter paper or
Gauze places weight at the top of filter paper or gauze；
Step 6: closing the piston of percolator lower end outlet, another part wine in step 2 be slowly added to the top of percolator,
Covered and enclosed for a period of time after, open percolator lower end outlet piston, seep percolate slowly with 0.8 ~ 1ml/min flow velocity
Stream；
Step 7: percolate described in collection step six is slowly added to rock sugar after collecting to percolate and stirs, makes ice
Sugar is completely dissolved, and liquid medicine semi-finished product are made；
Step 8: staticly settling in the phase in liquid medicine semi-finished product, and clarifying agent is added, after staticly settling at least 20 days, filtering；
Step 9: through filter-cloth filtering and collecting filtrate for the made liquid medicine semi-finished product of step 8, and filter cloth mesh number is 120 ~ 150 mesh；
Step 10: by required bottle by sterilizing after, Ms's liquid medicine made in step 9 is fitted into bottle complete it is filling.
6. a kind of preparation method of enriching yin beauty Mrs's protect liver liquid medicine according to claim 5, it is characterised in that: step 8
It can be replaced by low temperature impurity removal method.
7. a kind of preparation method of enriching yin beauty Mrs's protect liver liquid medicine according to claim 5, it is characterised in that: described low
The step of warm impurity removal method are as follows: the liquid medicine semi-finished product after staticly settling are set in freezing equipment, are down to -15 to liquid medicine semi-finished product temperature
DEG C when, stop cooling, take out liquid medicine semi-finished product, then temperature is allowed to go up naturally to 5 DEG C, filtering.
8. a kind of preparation method of enriching yin beauty Mrs's protect liver liquid medicine according to claim 5, it is characterised in that: described clear
Clear agent is the diatomite for being equivalent to the medicinal material mixture weight 0.05 ~ 0.1%.
9. a kind of preparation method of enriching yin beauty Mrs's protect liver liquid medicine according to claim 5, it is characterised in that: described clear
Clear agent includes protein flocculant, amphoteric polyacrylamide flocculant and 101 fruit juice clarifiers, and the dosage of the clarifying agent is
It is equivalent to the 0.03 ~ 0.05% of the medicinal material mixture weight.
10. a kind of preparation method of enriching yin beauty Mrs's protect liver liquid medicine according to claim 9, it is characterised in that: described
The ratio of protein flocculant, amphoteric polyacrylamide flocculant and 101 fruit juice clarifiers is 2:1:2.
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| CN102268353A (en) * | 2011-07-22 | 2011-12-07 | 张宏伟 | Chinese wolfberry wine and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102268353A (en) * | 2011-07-22 | 2011-12-07 | 张宏伟 | Chinese wolfberry wine and preparation method thereof |
| CN103131610A (en) * | 2013-02-28 | 2013-06-05 | 徐州古彭酒业有限公司 | Women's face nourishing and beauty treatment wine, and its preparation method |
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| CN115572655A (en) * | 2022-10-09 | 2023-01-06 | 陈铖 | Skin-beautifying toxin-expelling health-care medicinal liquor and brewing process thereof |
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