CN110302126A - Gargle tablet and preparation method thereof containing artificial saliva - Google Patents
Gargle tablet and preparation method thereof containing artificial saliva Download PDFInfo
- Publication number
- CN110302126A CN110302126A CN201910693506.8A CN201910693506A CN110302126A CN 110302126 A CN110302126 A CN 110302126A CN 201910693506 A CN201910693506 A CN 201910693506A CN 110302126 A CN110302126 A CN 110302126A
- Authority
- CN
- China
- Prior art keywords
- bicarbonate
- gargle
- agent
- gargle tablet
- carbonate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0208—Tissues; Wipes; Patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/23—Sulfur; Selenium; Tellurium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/22—Gas releasing
- A61K2800/222—Effervescent
Abstract
The present invention relates to the gargle tablets and preparation method thereof containing artificial saliva, belong to dental care product field.The present invention provides the gargle tablets containing artificial saliva, the gargle tablet is divided into piece sandwich layer and coatings, wherein, the plant and/or its extract, disintegrating agent, carbonate and/or bicarbonate, sour agent and filler, coatings that piece sandwich layer contains the integration of drinking and medicinal herbs with oral cavity fresh and cool effect contain artificial saliva.Compared to oral-cavity cleaning products such as traditional toothpaste, gargle tablets, product of the present invention is not required to additionally drink water after improvement, into oral cavity after by a small amount of saliva in oral cavity can flash melt, most can achieve and be completely dissolved within 30s fastly.In addition, gargle tablet of the present invention also has oral cleaning and fresh breath effects are good, a variety of advantages such as at low cost, have a vast market foreground.
Description
Technical field
The present invention relates to the gargle tablets and preparation method thereof containing artificial saliva, belong to dental care product field.
Background technique
With the development of food industry and the raising of living standards of the people, people increasingly pay attention to oral hygiene, are passing
The novel products such as chewing gum, mouthwash have gradually been developed on the basis of system oral-cavity cleaning products toothpaste.But it either gargles
The use of water or chewing gum has its limitation and harm.
Mouthwash long-time service will cause intraoral normal flora imbalance, serious to will form ulcer, it is also possible to meeting
Increase the risk for suffering from diabetes.It frequently also will increase the danger of heart disease and stroke using mouthwash.Mouthwash should be used with caution in children,
Prevent mouthwash from accidentally being gulped down and causing to stimulate to the stomach of child.Moreover, mouthwash there is a problem of inconvenient to carry, especially exist
Forbid to carry when airplane.
Chewing gum needs to carry out residue processing after use, is unfavorable for environmental protection.Acid corrigent in sugar-free chewing gum
The concern of people is less subject to preservative, but these additives can but have a adverse impact to the health of tooth, such as
Dental erosion.The people to suffer from indiestion, long-time chew gum can secrete reflexively a large amount of gastric acids, lead to digestive system
Palindromia aggravates.Chewing gum on an empty stomach can also be such that digestive ferment increases and the symptoms such as nausea, sour regurgitation water that rise.
In terms of target user, for young child and old old man, mouthwash and chewing gum are not reasons
The oral-cavity cleaning products thought either eat mouthwash or chewing gum by mistake, all can generate harm to human body.
Therefore, oral cleaning, care product that a suitable all groups can use in different occasions, are developed
It is necessary.Due to gargle tablet either target user, be applicable in place and in terms of will be better than it is traditional
Chewing gum and mouthwash, the exploitation of Related product are increasingly becoming the research hotspot of this field.For example, Chinese patent CN
107510747A、CN 104383350A、CN 105031614A、CN 104188820A、CN 108042421A、CN
104473822A、CN 107510747A、CN 105982835A、CN 10598821A、CN 107897422A、CN
106619318A, CN 106309148A, CN 108815001A all refer to the preparation of gargle tablet.However, above-mentioned gargle tablet exists
It requires additionally to drink water when use, if it is only excessively slow by the effect solution rate of saliva of buccal cavity, or even be unable to fully dissolve, shadow
Ring the performance of its cleaning action；Moreover, can not spit under special circumstances, using above remaining apparent inconvenience.
Summary of the invention
The present invention is directed at least solve one of the technical problems existing in the prior art.For this purpose, it is an object of the invention to
Gargle tablet and preparation method thereof containing artificial saliva is provided.
The present invention provides the gargle tablet containing artificial saliva, the gargle tablet is divided into piece sandwich layer and coatings, wherein label
Plant of the layer containing the integration of drinking and medicinal herbs with oral cavity fresh and cool effect and/or its extract, disintegrating agent, carbonate and/or bicarbonate
Salt, sour agent and filler, coatings contain artificial saliva.
Wherein, artificial saliva is the ingredient according to body metabolism product saliva, artificially makes the solution come, chemistry
Ingredient is similar to the saliva of people.The artificial saliva be used for gargle tablet recipe ingredient when, only in terms of solute component, disregard water
Weight.
Further, the disintegrating agent account for the 2~11% of label layer weight, the carbonate and/or bicarbonate and
Sour agent total amount accounts for the 20~50% of label layer weight.
Preferably, the disintegrating agent accounts for the 5~8% of label layer weight.
Preferably, the carbonate and/or bicarbonate and sour agent total amount account for the 30~50% of label layer weight.
Most preferably, the disintegrating agent accounts for the 8% of label layer weight, the carbonate and/or bicarbonate and sour agent
Total amount accounts for the 40% of label layer weight.
The main function that carbonate and/or bicarbonate rise with sour agent is reacted to each other after contact wetting, generates two
Carbonoxide, therefore the ratio of the two can play one's part to the full on the basis of meeting the stoichiometric ratio of above-mentioned reaction equation.
Preferably, sour agent: the mass ratio of carbonate and/or bicarbonate is (0.5:0.6)~(0.3:0.5).Most preferably, sour agent:
The mass ratio of carbonate and/or bicarbonate is 0.8:1.
Further, the disintegrating agent is selected from dried starch, sodium carboxymethyl starch, microcrystalline cellulose, low substituted hydroxy-propyl
It is cellulose, croscarmellose sodium, one or more kinds of in crospovidone.It is excellent
Selection of land, the disintegrating agent are crospovidone.
Further, the carbonate and/or bicarbonate are selected from sodium carbonate, potassium carbonate, sodium bicarbonate, bicarbonate
It is one or more kinds of in potassium, calcium carbonate.
Preferably, the bicarbonate is sodium bicarbonate.
Further, the sour agent is selected from organic acid.
Preferably, the sour agent in citric acid, tartaric acid, hexanedioic acid, malic acid, fumaric acid one or two with
On.
Preferably, the sour agent is citric acid.
Further, the plant of the integration of drinking and medicinal herbs and/or its extract meet at least one of following:
The plant of the integration of drinking and medicinal herbs is one or more kinds of in lily, peppermint, Siraitia grosvenorii, chrysanthemum；
Preferably, Bulbus Lilii extract is water extract；
Preferably, Bulbus Lilii extract is prepared by the following method to obtain: lily is taken, the water of 10 times of weight is added, is decocted 3 times,
Each 1h merges 3 decoction liquors, concentration, it is dry to get；
Preferably, dry use is spray-dried；
Preferably, the condition of Bulbus Lilii extract spray drying are as follows: charging rate 15mL/min, inlet air temperature are 180 DEG C,
Leaving air temp is 90 DEG C, and blower frequency is 100m3/ h, atomizing pressure 0.2MPa；
Preferably, Bulbus Lilii extract accounts for the 10~30% of label layer weight；
It is further preferred that Bulbus Lilii extract accounts for the 20% of label layer weight.
Further, the filler be selected from starch, sucrose, lactose, pregelatinized starch, microcrystalline cellulose, inorganic salts,
It is one or more kinds of in sugar alcohol.
Preferably, the filler is xylitol.
Further, the piece sandwich layer meets at least one of following:
Also containing auxiliary material one or more kinds of in wetting agent, adhesive, lubricant；
Preferably, the wetting agent is selected from or mixtures thereof water, ethyl alcohol；
Preferably, the adhesive it is a kind of in povidone, hydroxypropyl methylcellulose, carmethose, syrup or
It is two or more；
Preferably, the lubricant accounts for the 1~3% of label layer weight；
Preferably, the lubricant accounts for the 2% of label layer weight；
Preferably, the lubricant it is a kind of in Macrogol 6000, talcum powder, magnesium stearate, superfine silica gel powder or
It is two or more；
It is further preferred that the lubricant is Macrogol 6000.
Further, coating meets at least one of following:
Filmogen is hydroxypropyl methyl cellulose；
Coating solution is 60%v/v ethanol water；
Preferably, the concentration of hydroxypropyl methyl cellulose is 3%w/w in coating solution；
Artificial saliva accounts for the 0.5~3% of coating solution weight；
Preferably, artificial saliva accounts for the 0.5~1% of coating solution weight；
Artificial saliva meets ISO/TR10271 standard, in terms of weight proportion, ingredient are as follows: 0.4 part of KCl, NaCl 0.4
Part, NaH2PO4·2H20.78 part of O, Na2S·2H20.005 part of O, CaCl2·2H20.795 part and 1 part of urea of O.
The present invention provides the preparation method of the gargle tablet, include the following steps: the supplementary material for taking piece sandwich layer, stirring is mixed
It is even, granulation, whole grain, tabletting, coating to get.
The present invention provides the gargle tablets containing artificial saliva, mainly have the advantage that
1, compared to oral-cavity cleaning products such as traditional toothpaste, gargle tablets, product of the present invention is not required to additionally drink after improvement
Water, into oral cavity after by a small amount of saliva in oral cavity can flash melt, most can achieve and be completely dissolved within 30s fastly.
2, the major ingredient of gargle tablet of the present invention and auxiliary material are food rank, while keeping oral cleaning and breath freshening
Can also swallow it is edible, it is more convenient to use, it is also more environmentally-friendly.
3, gargle tablet of the present invention has the characteristics that " thin ", " small ", " skilful ", easy to carry, is particularly suitable for going on business, travel
Special occasions uses.
4, contain artificial saliva in the coatings of gargle tablet of the present invention, can preferably avoid in oral cavity saliva very little and nothing
The rapidly-soluble problem of method.
To sum up, gargle tablet of the present invention is shown, solution rate is fast, oral cleaning and fresh breath effects are good, cost
A variety of advantages such as low, easy to use, have a vast market foreground.
Specific embodiment
The present invention provides the gargle tablet containing artificial saliva, the gargle tablet is divided into piece sandwich layer and coatings, wherein label
Plant of the layer containing the integration of drinking and medicinal herbs with oral cavity fresh and cool effect and/or its extract, disintegrating agent, carbonate and/or bicarbonate
Salt, sour agent and filler, coatings contain artificial saliva.
Key point of the invention is for disintegrating agent, carbonate and/or bicarbonate and sour agent to be applied in combination to prepare
The huge core of the piece of gargle tablet.If disintegrating agent is used alone, the disintegration time limited of gargle tablet is longer；On the other hand, if carbonic acid is used alone
Salt and/or bicarbonate and sour agent, user need additional drinking-water that can just gargle tablet be made to be disintegrated, and can not be only by absorbing saliva
Realize the purpose in cleaning oral cavity.The present invention combines above-mentioned three kinds of auxiliary materials, after gained gargle tablet and a small amount of saliva contacts
Fater disintegration in a short time, while a large amount of foams are generated, it can guarantee that active constituent therein comes into full contact with oral cavity, to reach
To the purpose in rapid cleaning oral cavity.On this basis, add artificial saliva in coatings, can it is very little to avoid saliva in oral cavity and
It can not quickly dissolve, help to further increase the solution rate of gargle tablet in the oral cavity.
The present invention can also have following additional technical feature:
Above-mentioned disintegrating agent, carbonate and/or bicarbonate and the content of sour agent can also generate gargle tablet disintegration rate
It influences.According to some embodiments of the present invention, the disintegrating agent accounts for the 2~11% of label layer weight, the carbonate and/or carbon
Sour hydrogen salt and sour agent total amount account for the 20~50% of label layer weight.Preferably, the disintegrating agent account for label layer weight 5~
8%.Preferably, the carbonate and/or bicarbonate and sour agent total amount account for the 30~50% of label layer weight.Preferably,
The disintegrating agent accounts for the 8% of label layer weight, the carbonate and/or bicarbonate and sour agent total amount accounts for label layer weight
40%.
Detailed description are as follows for influence of the auxiliary material content to gargle tablet disintegration rate, pulls out seed extract as active constituent using open country
The gargle tablet of preparation illustrates.Pull out the extraction process of seed extract in open country used in hereafter are as follows: weigh open country and pull out son
The water of 30 times of quality is added in the leaf 200g of the dry zone spray of Elsholtzia rugulosa Hemsl., and temperature is set as 60 DEG C,
It decocts 3 times, each 1h；Merge 3 decoction filtrates, filters, obtain decoction liquor；Decoction liquor is set to carry out in vacuum concentration boiling machine
Concentration, temperature setting are 60 DEG C；Decoction liquor after concentration is placed in spray granulator and is spray-dried, quickly by decoction liquor
In moisture be evaporated, be made as medicinal extract；The medicinal extract made is crushed again, open country is made and pulls out seed extract powder；It is spray-dried item
Part are as follows: medicinal extract relative density is 1.10-1.15g/ml (room temperature), and charging rate 5mL/min, inlet air temperature is 100 DEG C, outlet air
Temperature is 90 DEG C, and blower frequency is 90m3/ h, atomizing pressure 0.2MPa.
The detection method of disintegration time limited are as follows: according to the disintegration time limit test of four middle tablets of " Chinese Pharmacopoeia " version in 2015
It carries out appropriate adjustment (aqueous solution is changed to artificial saliva), so that the measuring method of disintegration time limited is more suitable for, the present invention is portable to gargle
Mouth piece.Wherein, oral environment of the configuration artificial saliva to simulate human body, artificial saliva formula use ISO/TR10271 standard,
It is configured using 1000mL distilled water as solvent, ingredient see the table below:
1 ISO/RT10271 standard intraocular's salivary component table of table
Note: it is 6.3 that solution, which adjusts pH value,.
1, disintegrant content
It is 20% that seed extract content is pulled out in fixed open country, and foaming agent (i.e. carbonate and/or bicarbonate+acid agent) content is
0%, 2%, 5%, 8%, 11% disintegrating agent PVPP (crospovidone), lubricant PEG6000 are added in gargle tablet respectively
(Macrogol 6000) content is 2%, remaining is filler xylitol, is prepared into tablet using conventional method, and then detection is collapsed
Solve the time limit.As a result it see the table below:
The different disintegrant content lower disintegration time limiteds of table 2
Table 2 the result shows that, in 2%, 5%, 8% and 11% disintegrant content, disintegrant content is collapsed at 8%
It is optimal to solve the time limit.In 2%-8% range, disintegration time limited declines disintegrant content with the increase of disintegrant content；Disintegration
In 8%-10% range, disintegration time limited rises agent content with the increase of disintegrant content.
2, foaming agent (i.e. carbonate and/or bicarbonate+acid agent) content
It is 20% that seed extract content is pulled out in fixed open country, and disintegrating agent PVPP content is 0%, is added in gargle tablet respectively
20%, 30%, 40%, 50% foaming agent (citric acid: sodium bicarbonate mass ratio is 0.8:1), lubricant PEG6000 content is
2%, remaining is filler xylitol, is prepared into tablet using conventional method, then detects disintegration time limited.As a result it see the table below:
The different foaming agents content lower disintegration time limiteds of table 3
Table 3 the result shows that, for foaming agents content be 20%, 30%, 40% and 50% when, foaming agents content 40%
When, disintegration time limited is optimal.Foaming agents content is in 20%-40% range, under disintegration time limited is with the increase of foaming agents content
Drop；In 40%-50% range, disintegration time limited rises foaming agents content with the increase of foaming agents content.
In the preferred content range of auxiliary material of the present invention, gargle tablet disintegration time limited is illustrated below:
The disintegration time limited of the gargle tablet of the present invention of table 4
From the results shown in Table 4, the gargle tablet prepared within the scope of currently preferred auxiliary material, in artificial saliva
Can fater disintegration, disintegration time limit in 1min or so, can satisfy the requirement of gargle tablet completely.Wherein, disintegration rate
Most fast ratio of adjuvant are as follows: disintegrant content 8%, foaming agents content 40% (i.e. the 5th group of gargle tablet).
According to some embodiments of the present invention, the disintegrating agent is preferably crospovidone.Using integration of drinking and medicinal herbs
When plant extracts is as gargle tablet active constituent, since extract viscosity itself is stronger, after general disintegrating agent film-making
Tension stress intensity value in blocks is excessive, and using crospovidone as disintegrating agent, tension stress intensity does not exceed the normal model of tablet
It encloses.
According to some embodiments of the present invention, the sour agent is preferably citric acid.Citric acid has soluble easily in water, mouthfeel
It is good, it is acid stronger, it is swift in response, the advantages that after dissolution without precipitating.
According to some embodiments of the present invention, the bicarbonate is preferably sodium bicarbonate.Sodium bicarbonate energy and lemon
Sour fast reaction in aqueous solution, releases a large amount of gas, while without precipitating.
According to some embodiments of the present invention, the filler is preferably xylitol.Xylitol has good preventing decayed tooth
Tooth characteristic can prevent the generation of saprodontia, avoid the damage to tooth clean simultaneously to oral cavity.It is filled out compared to other
It fills for agent, xylitol sugariness is suitable with sucrose, can also improve the mouthfeel of gargle tablet.
According to some embodiments of the present invention, the lubricant is preferably Macrogol 6000.Compared to other types
Lubricant, Macrogol 6000 has preferably water-soluble, will not have an adverse effect to the mouthfeel of gargle tablet, and anti-stick
Property is excellent.
According to some embodiments of the present invention, it joined dual-purpose of drug and food Bulbus Lilii extract in gargle tablet.Lily energy moistening lung stops
Cough, clearing away the heart fire and tranquillizing are more beneficial to body and mind.
The solution of the present invention is explained below in conjunction with embodiment.It will be understood to those of skill in the art that following
Embodiment is merely to illustrate the present invention, and should not be taken as limiting the scope of the invention.Particular technique or item are not specified in embodiment
Part, it described technology or conditions or is carried out according to the literature in the art according to product description.Agents useful for same or instrument
Production firm person is not specified in device, and being can be with conventional products that are commercially available.Artificial saliva used in the following embodiment
Meet ISO/TR10271 standard, is specifically shown in Table 1.
The preparation of the gargle tablet of the present invention of embodiment 1
A, it extracts: weighing lily 500g, 10 times of water (w/w) is added to decoct 3 times, each 1h, collecting decoction, filtration must decoct
Liquid is condensed into the clear cream that relative density is 1.25~1.30g/ml (room temperature).
B, it is spray-dried: clear cream being placed in progress pharmacy powder in spray granulator, sieves with 100 mesh sieve, about obtains Bulbus Lilii extract
75g, it is spare.Spray drying condition are as follows: charging rate 15mL/min, inlet air temperature are 180 DEG C, and leaving air temp is 90 DEG C, wind
Unit frequency is 100m3/ h, atomizing pressure 0.2MPa.
C, mixing, granulation: by mass percentage, Bulbus Lilii extract 20% is taken, citric acid: sodium bicarbonate (0.5:0.6,
W:w) 30%, disintegrating agent PVPP 10%, filler xylitol 30%, lubricant PEG 60002% are stirred and evenly mixed, 75% ethyl alcohol
Wet granulation is prepared into particle；
D, whole grain tabletting: granulate mixture made from step c is placed into tablet press machine and carries out tabletting, it is smooth that rule is made
Sheet products；
E, it is coated: with the 60%v/v ethanol water containing 3%w/w hydroxypropyl methyl cellulose and 0.5%w/w artificial saliva
Solution is coated (0.15~0.2kg/min of flow, pressure 0.4MPa, 60~70 DEG C of heated-air drying temperature), polishing, and cool.
F, it packs: light aluminium plastic membrane being selected to pack finished product.
Gargle tablet 6 (slice weight 0.5g) is taken, disintegration time limited is detected in artificial saliva, each tablet all collapses in 30s
Solution is dissolved.
The preparation of the gargle tablet of the present invention of embodiment 2
Bulbus Lilii extract is prepared as described in Example 1, then by mass percentage, takes Bulbus Lilii extract 10%, lemon
Lemon acid: sodium bicarbonate (0.3:0.5, w:w) 25%, disintegrating agent PVPP 6%, filler xylitol 23%, lubricant PEG
60001%, it stirs and evenly mixs, 80% ethyl alcohol wet granulation is prepared into particle, whole grain tabletting.To contain 3%w/w hydroxypropyl methyl
The 60%v/v ethanol water of cellulose and 1%w/w artificial saliva is coated (0.15~0.2kg/min of flow, pressure
0.4MPa, 60~70 DEG C of heated-air drying temperature), aluminium plastic membrane packaging to get.
The preparation of the gargle tablet of the present invention of embodiment 3
Bulbus Lilii extract is prepared as described in Example 1, then by mass percentage, takes Bulbus Lilii extract 30%, lemon
Lemon acid: sodium bicarbonate (0.3:0.5, w:w) 45%, disintegrating agent PVPP 10%, filler xylitol 12%, lubricant PEG
60003%, it stirs and evenly mixs, 60% ethyl alcohol wet granulation is prepared into particle, whole grain tabletting.To contain 3%w/w hydroxypropyl methyl
The 60%v/v ethanol water of cellulose and 1%w/w artificial saliva is coated (0.15~0.2kg/min of flow, pressure
0.4MPa, 60~70 DEG C of heated-air drying temperature), aluminium plastic membrane packaging to get.
It should be noted that particular features, structures, materials, or characteristics described in this specification can any one or
It can be combined in any suitable manner in multiple embodiments.In addition, without conflicting with each other, those skilled in the art can incite somebody to action
The feature of difference embodiment described in this specification and different embodiments is combined.
Claims (10)
1. the gargle tablet containing artificial saliva, it is characterized in that: the gargle tablet is divided into piece sandwich layer and coatings, wherein piece sandwich layer contains
There are plant and/or its extract, disintegrating agent, carbonate and/or the bicarbonate, acid of the integration of drinking and medicinal herbs with oral cavity fresh and cool effect
Agent and filler, coatings contain artificial saliva.
2. gargle tablet as described in claim 1, it is characterized in that: the disintegrating agent accounts for the 2~11% of label layer weight, the carbon
Hydrochlorate and/or bicarbonate and sour agent total amount account for the 20~50% of label layer weight；Preferably, the disintegrating agent accounts for piece sandwich layer
The 5~8% of weight；Preferably, the carbonate and/or bicarbonate and sour agent total amount account for label layer weight 30~
50%；Most preferably, the disintegrating agent accounts for the 8% of label layer weight, the carbonate and/or bicarbonate and sour agent total amount
Account for the 40% of label layer weight；Preferably, sour agent: the mass ratio of carbonate and/or bicarbonate be (0.5:0.6)~(0.3:
0.5)；Most preferably, sour agent: the mass ratio of carbonate and/or bicarbonate is 0.8:1.
3. gargle tablet as claimed in claim 1 or 2, it is characterized in that: the disintegrating agent is selected from dried starch, carboxymethyl starch
Sodium, microcrystalline cellulose, low-substituted hydroxypropyl cellulose, croscarmellose sodium, in crospovidone one or two with
On；Preferably, the disintegrating agent is crospovidone.
4. gargle tablet as claimed in claim 1 or 2, it is characterized in that: the carbonate and/or bicarbonate are selected from carbonic acid
It is sodium, potassium carbonate, sodium bicarbonate, saleratus, one or more kinds of in calcium carbonate；Preferably, the bicarbonate is carbon
Sour hydrogen sodium.
5. gargle tablet as claimed in claim 1 or 2, it is characterized in that: the sour agent is selected from organic acid；Preferably, described
Sour agent is one or more kinds of in citric acid, tartaric acid, hexanedioic acid, malic acid, fumaric acid；Preferably, the sour agent
For citric acid.
6. gargle tablet as described in claim 1, it is characterized in that: the plant of the integration of drinking and medicinal herbs and/or its extract meet with
It is at least one of lower:
The plant of the integration of drinking and medicinal herbs is one or more kinds of in lily, peppermint, Siraitia grosvenorii, chrysanthemum；
Preferably, Bulbus Lilii extract is water extract；
Preferably, Bulbus Lilii extract is prepared by the following method to obtain: taking lily, is added the water of 10 times of weight, decoct 3 times, every time
1h merges 3 decoction liquors, concentration, it is dry to get；
Preferably, dry use is spray-dried；
Preferably, the condition of Bulbus Lilii extract spray drying are as follows: charging rate 15mL/min, inlet air temperature are 180 DEG C, outlet air
Temperature is 90 DEG C, and blower frequency is 100m3/ h, atomizing pressure 0.2MPa；
Preferably, Bulbus Lilii extract accounts for the 10~30% of label layer weight；
It is further preferred that Bulbus Lilii extract accounts for the 20% of label layer weight.
7. gargle tablet as described in claim 1, it is characterized in that: the filler is selected from starch, sucrose, lactose, pregelatinated
It is starch, microcrystalline cellulose, inorganic salts, one or more kinds of in sugar alcohol；Preferably, the filler is xylitol.
8. gargle tablet as described in claim 1, it is characterized in that: at least one of below the piece sandwich layer satisfaction:
Also containing auxiliary material one or more kinds of in wetting agent, adhesive, lubricant；
Preferably, the wetting agent is selected from or mixtures thereof water, ethyl alcohol；
Preferably, the adhesive is one or two kinds of in povidone, hydroxypropyl methylcellulose, carmethose, syrup
More than；
Preferably, the lubricant accounts for the 1~3% of label layer weight；
Preferably, the lubricant accounts for the 2% of label layer weight；
Preferably, the lubricant is one or two kinds of in Macrogol 6000, talcum powder, magnesium stearate, superfine silica gel powder
More than；
It is further preferred that the lubricant is Macrogol 6000.
9. gargle tablet as described in claim 1, it is characterized in that: at least one of below coating satisfaction:
Filmogen is hydroxypropyl methyl cellulose；
Coating solution is 60%v/v ethanol water；
Preferably, the concentration of hydroxypropyl methyl cellulose is 3%w/w in coating solution；
Artificial saliva accounts for the 0.5~3% of coating solution weight；
Preferably, artificial saliva accounts for the 0.5~1% of coating solution weight；
Artificial saliva meets ISO/TR10271 standard, in terms of weight proportion, ingredient are as follows: 0.4 part of KCl, 0.4 part of NaCl,
NaH2PO4·2H20.78 part of O, Na2S·2H20.005 part of O, CaCl2·2H20.795 part and 1 part of urea of O.
10. the preparation method of gargle tablet described in claim 1~9 any one, it is characterized in that: including the following steps: to take label
Layer supplementary material, stir and evenly mix, pelletize, whole grain, tabletting, coating to get.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910693506.8A CN110302126A (en) | 2019-07-30 | 2019-07-30 | Gargle tablet and preparation method thereof containing artificial saliva |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910693506.8A CN110302126A (en) | 2019-07-30 | 2019-07-30 | Gargle tablet and preparation method thereof containing artificial saliva |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110302126A true CN110302126A (en) | 2019-10-08 |
Family
ID=68082381
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910693506.8A Pending CN110302126A (en) | 2019-07-30 | 2019-07-30 | Gargle tablet and preparation method thereof containing artificial saliva |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110302126A (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103083209A (en) * | 2013-01-25 | 2013-05-08 | 中山大学 | Master slice for mouthwash and preparation method thereof |
| CN105982821A (en) * | 2015-06-14 | 2016-10-05 | 胡雅群 | Portable solid herbal mouthwash effervescent tablets and preparation method thereof |
| CN107510747A (en) * | 2017-08-04 | 2017-12-26 | 上海中华药业南通有限公司 | A kind of effervescent tablet for rinsing mouth and preparation method thereof |
| CN108815001A (en) * | 2018-07-02 | 2018-11-16 | 郑州博凯医药保健品有限公司 | Mouthwash effervescent tablet and its preparation method and application |
-
2019
- 2019-07-30 CN CN201910693506.8A patent/CN110302126A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103083209A (en) * | 2013-01-25 | 2013-05-08 | 中山大学 | Master slice for mouthwash and preparation method thereof |
| CN105982821A (en) * | 2015-06-14 | 2016-10-05 | 胡雅群 | Portable solid herbal mouthwash effervescent tablets and preparation method thereof |
| CN107510747A (en) * | 2017-08-04 | 2017-12-26 | 上海中华药业南通有限公司 | A kind of effervescent tablet for rinsing mouth and preparation method thereof |
| CN108815001A (en) * | 2018-07-02 | 2018-11-16 | 郑州博凯医药保健品有限公司 | Mouthwash effervescent tablet and its preparation method and application |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| TW391880B (en) | An oral soluble type compression moulding and its preparation | |
| CN101868228B (en) | Orally disintegrating tablet | |
| CN100428926C (en) | Orally disintegrating tablets and process for obtaining them | |
| CN1222317C (en) | Quickly disintegrable compression-molded materials and process for producing the same | |
| JP4802436B2 (en) | Orally disintegrating composition and orally disintegrating preparation | |
| CA2440361A1 (en) | Intraorally rapidly disintegrable preparation | |
| WO2007074856A1 (en) | Method of producing solid preparation disintegrating in the oral cavity | |
| JPH0948726A (en) | Rapidly disintegrating preparation in mouth cavity and its production | |
| CN1530139A (en) | Copmosition containnig dichloride sugar | |
| EP1343481A2 (en) | Process for the preparation of a fast dissolving dosage form | |
| CN110200931A (en) | A kind of calcium vitamin D chewable tablets | |
| SK74396A3 (en) | Organoleptically acceptable oral pharmaceutical compositions | |
| TW200927198A (en) | Improved tablet coating | |
| CN1315483C (en) | Compositions internal or relevant improvement | |
| CN102327244B (en) | Ambroxol hydrochloride orally disintegrating tablet and preparation method thereof | |
| CN1742957A (en) | Sangju effervescent tablet for treating common cold | |
| CN107095853A (en) | A kind of oral disnitegration tablet disintegrant combination and its application method | |
| CN102258490B (en) | Ibuprofen chewable tablet | |
| CN110302098A (en) | Mint flavored gargle tablet containing artificial saliva and preparation method thereof | |
| CN110251444A (en) | The gargle tablet of easy disintegrating | |
| CN101401796A (en) | Pramipexole orally disintegrating tablets and preparation method thereof | |
| CN110302126A (en) | Gargle tablet and preparation method thereof containing artificial saliva | |
| JP6262490B2 (en) | Intraoral rapidly disintegrating tablet composition | |
| CN102210453A (en) | Effervescent chewing gum and preparation method thereof | |
| JP6104038B2 (en) | Composite composition of crystalline cellulose |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20191008 |
|
| RJ01 | Rejection of invention patent application after publication |