CN110251444A - The gargle tablet of easy disintegrating - Google Patents
The gargle tablet of easy disintegrating Download PDFInfo
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- CN110251444A CN110251444A CN201910693815.5A CN201910693815A CN110251444A CN 110251444 A CN110251444 A CN 110251444A CN 201910693815 A CN201910693815 A CN 201910693815A CN 110251444 A CN110251444 A CN 110251444A
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- bicarbonate
- agent
- gargling
- carbonate
- gargle
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0208—Tissues; Wipes; Patches
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/817—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions or derivatives of such polymers, e.g. vinylimidazol, vinylcaprolactame, allylamines (Polyquaternium 6)
- A61K8/8176—Homopolymers of N-vinyl-pyrrolidones. Compositions of derivatives of such polymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Abstract
The present invention relates to the gargle tablets of easy disintegrating, belong to dental care product field.The present invention provides the gargle tablet of easy disintegrating, it contains active constituent, disintegrating agent, carbonate and/or bicarbonate with oral cavity fresh and cool effect, sour agent and filler.Compared to oral-cavity cleaning products such as traditional toothpaste, gargle tablets, product of the present invention is not required to additionally drink water after improvement, into oral cavity after by a small amount of saliva in oral cavity can flash melt, most can achieve and be completely dissolved within 30s fastly.In addition, gargle tablet of the present invention also has oral cleaning and fresh breath effects are good, a variety of advantages such as at low cost, have a vast market foreground.
Description
Technical field
The present invention relates to the gargle tablets of easy disintegrating, belong to dental care product field.
Background technique
With the development of food industry and the raising of living standards of the people, people increasingly pay attention to oral hygiene, are passing
The novel products such as chewing gum, mouthwash have gradually been developed on the basis of system oral-cavity cleaning products toothpaste.But it either gargles
The use of water or chewing gum has its limitation and harm.
Mouthwash long-time service will cause intraoral normal flora imbalance, serious to will form ulcer, it is also possible to meeting
Increase the risk for suffering from diabetes.It frequently also will increase the danger of heart disease and stroke using mouthwash.Mouthwash should be used with caution in children,
Prevent mouthwash from accidentally being gulped down and causing to stimulate to the stomach of child.Moreover, mouthwash there is a problem of inconvenient to carry, especially exist
Forbid to carry when airplane.
Chewing gum needs to carry out residue processing after use, is unfavorable for environmental protection.Acid corrigent in sugar-free chewing gum
The concern of people is less subject to preservative, but these additives can but have a adverse impact to the health of tooth, such as
Dental erosion.The people to suffer from indiestion, long-time chew gum can secrete reflexively a large amount of gastric acids, lead to digestive system
Palindromia aggravates.Chewing gum on an empty stomach can also be such that digestive ferment increases and the symptoms such as nausea, sour regurgitation water that rise.
In terms of target user, for young child and old old man, mouthwash and chewing gum are not reasons
The oral-cavity cleaning products thought either eat mouthwash or chewing gum by mistake, all can generate harm to human body.
Therefore, oral cleaning, care product that a suitable all groups can use in different occasions, are developed
It is necessary.Due to gargle tablet either target user, be applicable in place and in terms of will be better than it is traditional
Chewing gum and mouthwash, the exploitation of Related product are increasingly becoming the research hotspot of this field.For example, Chinese patent CN
107510747A、CN 104383350A、CN 105031614A、CN 104188820A、CN 108042421A、CN
104473822A、CN 107510747A、CN 105982835A、CN 10598821A、CN 107897422A、CN
106619318A, CN 106309148A, CN 108815001A all refer to the preparation of gargle tablet.However, above-mentioned gargle tablet exists
It requires additionally to drink water when use, if it is only excessively slow by the effect solution rate of saliva of buccal cavity, or even be unable to fully dissolve, shadow
Ring the performance of its cleaning action；Moreover, can not spit under special circumstances, using above remaining apparent inconvenience.
Summary of the invention
The present invention is directed at least solve one of the technical problems existing in the prior art.For this purpose, it is an object of the invention to
The gargle tablet of easy disintegrating is provided.
The present invention provides the gargle tablet of easy disintegrating, contain active constituent, disintegrating agent, carbon with oral cavity fresh and cool effect
Hydrochlorate and/or bicarbonate, sour agent and filler.
Further, the disintegrating agent account for the 2~11% of sheet weight of gargling, the carbonate and/or bicarbonate and
Sour agent total amount accounts for the 20~50% of sheet weight of gargling.
Preferably, the disintegrating agent accounts for the 5~8% of sheet weight of gargling.
Preferably, the carbonate and/or bicarbonate and sour agent total amount account for the 30~50% of sheet weight of gargling.
Most preferably, the disintegrating agent accounts for the 8% of sheet weight of gargling, the carbonate and/or bicarbonate and sour agent
Total amount accounts for the 40% of sheet weight of gargling.
The main function that carbonate and/or bicarbonate rise with sour agent is reacted to each other after contact wetting, generates two
Carbonoxide, therefore the ratio of the two can play one's part to the full on the basis of meeting the stoichiometric ratio of above-mentioned reaction equation.
Preferably, sour agent: the mass ratio of carbonate and/or bicarbonate is (0.5:0.6)~(0.3:0.5).Most preferably, sour agent:
The mass ratio of carbonate and/or bicarbonate is 0.8:1.
Further, the disintegrating agent is selected from dried starch, sodium carboxymethyl starch, microcrystalline cellulose, low substituted hydroxy-propyl
It is cellulose, croscarmellose sodium, one or more kinds of in crospovidone.
Preferably, the disintegrating agent is crospovidone.
Further, the carbonate and/or bicarbonate are selected from sodium carbonate, potassium carbonate, sodium bicarbonate, bicarbonate
It is one or more kinds of in potassium, calcium carbonate.
Preferably, the bicarbonate is sodium bicarbonate.
Further, the sour agent is selected from organic acid.
Preferably, the sour agent in citric acid, tartaric acid, hexanedioic acid, malic acid, fumaric acid one or two with
On.
Preferably, the sour agent is citric acid.
Further, the active constituent with oral cavity fresh and cool effect meets at least one of following:
Selected from the plant of integration of drinking and medicinal herbs and/or its extract, open country pull out sub- Elsholtzia rugulosa Hemsl. and/or
Its extract；
Preferably, the plant of the integration of drinking and medicinal herbs is one or more kinds of in lily, peppermint, Siraitia grosvenorii, chrysanthemum；
Preferably, it is branch and/or leaf that the medicinal part of son is pulled out in the open country.
Further, the active constituent with oral cavity fresh and cool effect meets at least one of following:
It is water extract that seed extract is pulled out in open country；
It pulls out seed extract and is prepared by the following method to obtain in open country: open country being taken to pull out son, the water of 30 times of quality is added, decoct 3 in 60 DEG C
Secondary, each 1h merges 3 decoction liquors, concentration, it is dry to get；
Preferably, dry use is spray-dried；
Preferably, the wild condition for pulling out seed extract spray drying are as follows: charging rate 5mL/min, inlet air temperature 100
DEG C, leaving air temp is 90 DEG C, and blower frequency is 90m3/ h, atomizing pressure 0.2MPa；
Preferably, wild to pull out seed extract accounts for sheet weight of gargling 5~20%；
It is further preferred that wild pull out seed extract accounts for sheet weight of gargling 10%；
Bulbus Lilii extract is water extract；
Bulbus Lilii extract is prepared by the following method to obtain: lily taken, the water of 10 times of weight is added, is decocted 3 times, each 1h,
Merge 3 decoction liquors, be concentrated, it is dry to get；
Preferably, dry use is spray-dried；
Preferably, the condition of Bulbus Lilii extract spray drying are as follows: charging rate 15mL/min, inlet air temperature are 180 DEG C,
Leaving air temp is 90 DEG C, and blower frequency is 100m3/ h, atomizing pressure 0.2MPa；
Preferably, Bulbus Lilii extract accounts for the 10~30% of sheet weight of gargling；
It is further preferred that Bulbus Lilii extract accounts for the 20% of sheet weight of gargling.
Further, the filler be selected from starch, sucrose, lactose, pregelatinized starch, microcrystalline cellulose, inorganic salts,
It is one or more kinds of in sugar alcohol；Preferably, the filler is xylitol.
Further, the gargle tablet meets at least one of following:
Also containing auxiliary material one or more kinds of in wetting agent, adhesive, lubricant；
Preferably, the wetting agent is selected from or mixtures thereof water, ethyl alcohol；
Preferably, the adhesive it is a kind of in povidone, hydroxypropyl methylcellulose, carmethose, syrup or
It is two or more；
Preferably, the lubricant accounts for the 1~3% of sheet weight of gargling；
It is further preferred that the lubricant accounts for the 2% of sheet weight of gargling；
Preferably, the lubricant it is a kind of in Macrogol 6000, talcum powder, magnesium stearate, superfine silica gel powder or
It is two or more；
It is further preferred that the lubricant is Macrogol 6000.
The present invention provides the adjuvant compositions of speeding up disintegration of tablet, contain disintegrating agent, carbonate and/or bicarbonate
And sour agent.
The present invention provides the gargle tablets of easy disintegrating, mainly have the advantage that
1, compared to oral-cavity cleaning products such as traditional toothpaste, gargle tablets, product of the present invention is not required to additionally drink after improvement
Water, into oral cavity after by a small amount of saliva in oral cavity can flash melt, most can achieve and be completely dissolved within 30s fastly.
2, the major ingredient of gargle tablet of the present invention and auxiliary material are safe and non-toxic, may be used also while keeping oral cleaning and breath freshening
It is more convenient to use to swallow, it is also more environmentally-friendly.
3, gargle tablet of the present invention has the characteristics that " thin ", " small ", " skilful ", easy to carry, is particularly suitable for going on business, travel
Special occasions uses.
To sum up, gargle tablet of the present invention is shown, solution rate is fast, oral cleaning and fresh breath effects are good, cost
A variety of advantages such as low, easy to use, have a vast market foreground.
Specific embodiment
The present invention provides the gargle tablets of easy disintegrating: containing active constituent, disintegrating agent, carbonic acid with oral cavity fresh and cool effect
Salt and/or bicarbonate, sour agent and filler.
Key point of the invention is for disintegrating agent, carbonate and/or bicarbonate and sour agent to be applied in combination to prepare
Gargle tablet.If disintegrating agent is used alone in gargle tablet, disintegration time limited is longer；On the other hand, if be used alone carbonate and/or
Bicarbonate and sour agent, user needs additional drinking-water that can just gargle tablet be made to be disintegrated, and can not only realize by absorption saliva clear
The purpose of clean mouth chamber.The present invention combines above-mentioned three kinds of auxiliary materials, can be in short-term after gained gargle tablet and a small amount of saliva contacts
Interior fater disintegration, while a large amount of foams are generated, it can guarantee that active constituent therein comes into full contact with oral cavity, to reach quick
Clean the purpose in oral cavity.
The present invention can also have following additional technical feature:
Above-mentioned disintegrating agent, carbonate and/or bicarbonate and the content of sour agent can also generate gargle tablet disintegration rate
It influences.According to some embodiments of the present invention, the disintegrating agent accounts for the 2~11% of sheet weight of gargling, the carbonate and/or carbon
Sour hydrogen salt and sour agent total amount account for the 20~50% of sheet weight of gargling.Preferably, the disintegrating agent account for sheet weight of gargling 5~
8%.Preferably, the carbonate and/or bicarbonate and sour agent total amount account for the 30~50% of sheet weight of gargling.Preferably,
The disintegrating agent accounts for the 8% of sheet weight of gargling, the carbonate and/or bicarbonate and sour agent total amount accounts for sheet weight of gargling
40%.
Detailed description are as follows for influence of the auxiliary material content to gargle tablet disintegration rate, pulls out seed extract as active constituent using open country
The gargle tablet of preparation illustrates.Pull out the extraction process of seed extract in open country used in hereafter are as follows: weigh open country and pull out son
The water of 30 times of quality is added in the leaf 200g of the dry zone spray of Elsholtzia rugulosa Hemsl., and temperature is set as 60 DEG C,
It decocts 3 times, each 1h；Merge 3 decoction filtrates, filters, obtain decoction liquor；Decoction liquor is set to carry out in vacuum concentration boiling machine
Concentration, temperature setting are 60 DEG C；Decoction liquor after concentration is placed in spray granulator and is spray-dried, quickly by decoction liquor
In moisture be evaporated, be made as medicinal extract；The medicinal extract made is crushed again, open country is made and pulls out seed extract powder；It is spray-dried item
Part are as follows: medicinal extract relative density is 1.10-1.15g/ml (room temperature), and charging rate 5mL/min, inlet air temperature is 100 DEG C, outlet air
Temperature is 90 DEG C, and blower frequency is 90m3/ h, atomizing pressure 0.2MPa.
The detection method of disintegration time limited are as follows: according to the disintegration time limit test of four middle tablets of " Chinese Pharmacopoeia " version in 2015
It carries out appropriate adjustment (aqueous solution is changed to artificial saliva), so that the measuring method of disintegration time limited is more suitable for, the present invention is portable to gargle
Mouth piece.Wherein, oral environment of the configuration artificial saliva to simulate human body, artificial saliva formula use ISO/TR10271 standard,
It is configured using 1000mL distilled water as solvent, ingredient see the table below:
1 ISO/RT10271 standard intraocular's salivary component table of table
Note: it is 6.3 that solution, which adjusts pH value,.
1, disintegrant content
It is 20% that seed extract content is pulled out in fixed open country, and foaming agent (i.e. carbonate and/or bicarbonate+acid agent) content is
0%, 2%, 5%, 8%, 11% disintegrating agent PVPP (crospovidone), lubricant PEG6000 are added in gargle tablet respectively
(Macrogol 6000) content is 2%, remaining is filler xylitol, is prepared into tablet using conventional method, and then detection is collapsed
Solve the time limit.As a result it see the table below:
The different disintegrant content lower disintegration time limiteds of table 2
Table 2 the result shows that, in 2%, 5%, 8% and 11% disintegrant content, disintegrant content is collapsed at 8%
It is optimal to solve the time limit.In 2%-8% range, disintegration time limited declines disintegrant content with the increase of disintegrant content；Disintegration
In 8%-10% range, disintegration time limited rises agent content with the increase of disintegrant content.
2, foaming agent (i.e. carbonate and/or bicarbonate+acid agent) content
It is 20% that seed extract content is pulled out in fixed open country, and disintegrating agent PVPP content is 0%, is added in gargle tablet respectively
20%, 30%, 40%, 50% foaming agent (citric acid: sodium bicarbonate mass ratio is 0.8:1), lubricant PEG6000 content is
2%, remaining is filler xylitol, is prepared into tablet using conventional method, then detects disintegration time limited.As a result it see the table below:
The different foaming agents content lower disintegration time limiteds of table 3
Table 3 the result shows that, for foaming agents content be 20%, 30%, 40% and 50% when, foaming agents content 40%
When, disintegration time limited is optimal.Foaming agents content is in 20%-40% range, under disintegration time limited is with the increase of foaming agents content
Drop；In 40%-50% range, disintegration time limited rises foaming agents content with the increase of foaming agents content.
Detailed description are as follows for influence of the active component content to gargle tablet disintegration rate: fixed foaming agent (citric acid: carbonic acid
Hydrogen sodium mass ratio is 0.8:1) content be 20%, disintegrating agent PVPP content be 8%, lubricant PEG6000 content be 2%, respectively
Open country is added in gargle tablet and pulls out seed extract 10%, 15%, 20%, 25%, remaining is filler xylitol, using conventional method
It is prepared into tablet, then detects disintegration time limited.As a result it see the table below:
4 different activities component content lower disintegration time limited of table
Table 4 the result shows that, influence of the active component content to gargle tablet disintegration time limited is smaller, influence degree be not so good as disintegrating agent
With the content of foaming agent.By taking seed extract is pulled out in open country as an example, content in 5%-10% range, pull out son with open country and mention by disintegration time limited
It takes the increase of object content and slightly declines；For content in 10%-20% range, disintegration time limited pulls out seed extract content with open country
Increase and slightly rises；It is most short that disintegration time limited when seed extract content is 10% is pulled out in open country.
In the preferred content range of supplementary material of the present invention, gargle tablet disintegration time limited is illustrated below:
Pull out the disintegration time limited of sub- gargle tablet in the open country of the present invention of table 5
From the results shown in Table 5, sub- gargle tablet is pulled out in the open country prepared within the scope of currently preferred supplementary material, in people
In work saliva can fater disintegration, disintegration time limit in 1min or so, can satisfy the requirement of gargle tablet completely.Wherein,
The most fast supplementary material proportion of disintegration rate are as follows: seed extract content 10% is pulled out in disintegrant content 8%, foaming agents content 40%, open country
(i.e. the 5th group of gargle tablet).
According to some embodiments of the present invention, the disintegrating agent is preferably crospovidone.Using integration of drinking and medicinal herbs
When plant extracts is as gargle tablet active constituent, since extract viscosity itself is stronger, after general disintegrating agent film-making
Tension stress intensity value in blocks is excessive, and using crospovidone as disintegrating agent, tension stress intensity does not exceed the normal model of tablet
It encloses.
According to some embodiments of the present invention, the sour agent is preferably citric acid.Citric acid has soluble easily in water, mouthfeel
It is good, it is acid stronger, it is swift in response, the advantages that after dissolution without precipitating.
According to some embodiments of the present invention, the bicarbonate is preferably sodium bicarbonate.Sodium bicarbonate energy and lemon
Sour fast reaction in aqueous solution, releases a large amount of gas, while without precipitating.
According to some embodiments of the present invention, the filler is preferably xylitol.Xylitol has good preventing decayed tooth
Tooth characteristic can prevent the generation of saprodontia, avoid the damage to tooth clean simultaneously to oral cavity.It is filled out compared to other
It fills for agent, xylitol sugariness is suitable with sucrose, can also improve the mouthfeel of gargle tablet.
According to some embodiments of the present invention, the lubricant is preferably Macrogol 6000.Compared to other types
Lubricant, Macrogol 6000 has preferably water-soluble, will not have an adverse effect to the mouthfeel of gargle tablet, and anti-stick
Property is excellent.
According to some embodiments of the present invention, it joined dual-purpose of drug and food Bulbus Lilii extract in gargle tablet.Lily energy moistening lung stops
Cough, clearing away the heart fire and tranquillizing are more beneficial to body and mind.
According to some embodiments of the present invention, it joined open country in gargle tablet and pull out son.Son is pulled out in open country, alias open country embankment, rugulose elsholtzia herb,
The leaf of the dry zone spray of sub- Elsholtzia rugulosa Hemsl. is pulled out for Elsholtzia willd Lamiaceae plant open country, is ethnic group
The conventional crude drugs of civil soaked tea-drinking treatment canker sore, gastroenteritis, have effects that expelling wind to resolve the exterior, dampness removing and promoting digestion and removing indigestion.It is wild
Pulling out son has preferable antibacterial, antiviral and promotion neural blood vessel unit repair.The sterilization component in son is pulled out with anti-in open country
Cancer and antidepressant effect have preferable Scavenging activity to hydroxy radical and active oxygen radical.Gargle tablet of the present invention is able to as a result,
The characteristics of pulling out the multiple target effects such as sub- expelling wind to resolve the exterior, dampness removing, antibacterial anti-inflammatory using open country is conducive to safeguard alimentary canal health.
The solution of the present invention is explained below in conjunction with embodiment.It will be understood to those of skill in the art that following
Embodiment is merely to illustrate the present invention, and should not be taken as limiting the scope of the invention.Particular technique or item are not specified in embodiment
Part, it described technology or conditions or is carried out according to the literature in the art according to product description.Agents useful for same or instrument
Production firm person is not specified in device, and being can be with conventional products that are commercially available.
Pull out the preparation of sub- gargle tablet in the open country of the present invention of embodiment 1
A, mixing, granulation: by mass percentage, open country is taken to pull out seed extract 5%, citric acid: sodium bicarbonate (0.3:0.5,
W:w) 30%, disintegrating agent PVPP 6%, filler xylitol 57%, lubricant PEG 60002% are stirred and evenly mixed, 70% ethyl alcohol
Wet granulation is prepared into particle；
B, whole grain tabletting: granulate mixture made from step a is placed into tablet press machine and carries out tabletting, it is smooth that rule is made
Sheet products；
C, it packs: light aluminium plastic membrane being selected to pack finished product.
Pull out the preparation of sub- gargle tablet in the open country of the present invention of embodiment 2
By mass percentage, take open country to pull out seed extract 10%, citric acid: sodium bicarbonate (0.4:0.5, w:w) 40% collapses
Agent PVPP 8%, filler xylitol 43% are solved, lubricant PEG 60001% is stirred and evenly mixed, 80% ethyl alcohol wet granulation, system
It is standby at particle, whole grain tabletting, aluminium plastic membrane packaging to get.
Pull out the preparation of sub- gargle tablet in the open country of the present invention of embodiment 3
By mass percentage, take open country to pull out seed extract 20%, citric acid: sodium bicarbonate (0.4:0.5, w:w) 50% collapses
Agent PVPP 10%, filler xylitol 18% are solved, lubricant PEG 60002% is stirred and evenly mixed, 70% ethyl alcohol wet granulation, system
It is standby at particle, whole grain tabletting, aluminium plastic membrane packaging to get.
The preparation of the lily gargle tablet of the present invention of embodiment 4
A, it extracts: weighing lily 500g, 10 times of water (w/w) is added to decoct 3 times, each 1h, collecting decoction, filtration must decoct
Liquid is condensed into the clear cream that relative density is 1.25~1.30g/ml (room temperature).
B, it is spray-dried: clear cream being placed in spray granulator, medicinal powder is made, sieved with 100 mesh sieve, about obtain Bulbus Lilii extract
75g, it is spare.Spray drying condition are as follows: charging rate 15mL/min, inlet air temperature are 180 DEG C, and leaving air temp is 90 DEG C, wind
Unit frequency is 100m3/ h, atomizing pressure 0.2MPa.
C, mixing, granulation: by mass percentage, Bulbus Lilii extract 20% is taken, citric acid: sodium bicarbonate (0.5:0.6,
W:w) 30%, disintegrating agent PVPP 10%, filler xylitol 30%, lubricant PEG 60002% are stirred and evenly mixed, 75% ethyl alcohol
Wet granulation is prepared into particle.
D, whole grain tabletting: granulate mixture made from step c is placed into tablet press machine and carries out tabletting, it is smooth that rule is made
Sheet products.
E, it packs: light aluminium plastic membrane being selected to pack finished product.
The gargle tablet that the present embodiment is prepared is subjected to disintegration time limited detection: taking gargle tablet (slice weight 0.5g) measurement disintegration
In the time limit, each tablet in 30s all dissolve by disintegration, as a result see the table below:
Table 6 disintegration time limited result
The preparation of the lily gargle tablet of the present invention of embodiment 5
Bulbus Lilii extract is prepared as described in Example 4, then by mass percentage, takes Bulbus Lilii extract 10%, lemon
Lemon acid: sodium bicarbonate (0.3:0.5, w:w) 30%, disintegrating agent PVPP6%, filler xylitol 17%, lubricant PEG
60001%, stir and evenly mix, 80% ethyl alcohol wet granulation, be prepared into particle, whole grain tabletting, aluminium plastic membrane packaging to get.
The preparation of the lily gargle tablet of the present invention of embodiment 6
Bulbus Lilii extract is prepared as described in Example 4, then by mass percentage, takes Bulbus Lilii extract 30%, lemon
Lemon acid: sodium bicarbonate (0.3:0.5, w:w) 45%, disintegrating agent PVPP10%, filler xylitol 12%, lubricant PEG
60003%, stir and evenly mix, 60% ethyl alcohol wet granulation, be prepared into particle, whole grain tabletting, aluminium plastic membrane packaging to get.
It should be noted that particular features, structures, materials, or characteristics described in this specification can any one or
It can be combined in any suitable manner in multiple embodiments.In addition, without conflicting with each other, those skilled in the art can incite somebody to action
The feature of difference embodiment described in this specification and different embodiments is combined.
Claims (10)
1. the gargle tablet of easy disintegrating, it is characterized in that: containing with oral cavity fresh and cool effect active constituent, disintegrating agent, carbonate and/
Or bicarbonate, sour agent and filler.
2. gargle tablet as described in claim 1, it is characterized in that: the disintegrating agent accounts for the 2~11% of sheet weight of gargling, the carbon
Hydrochlorate and/or bicarbonate and sour agent total amount account for the 20~50% of sheet weight of gargling；Preferably, the disintegrating agent accounts for gargle tablet
The 5~8% of weight；Preferably, the carbonate and/or bicarbonate and sour agent total amount account for sheet weight of gargling 30~
50%；Most preferably, the disintegrating agent accounts for the 8% of sheet weight of gargling, the carbonate and/or bicarbonate and sour agent total amount
Account for the 40% of sheet weight of gargling；Preferably, sour agent: the mass ratio of carbonate and/or bicarbonate be (0.5:0.6)~(0.3:
0.5)；Most preferably, sour agent: the mass ratio of carbonate and/or bicarbonate is 0.8:1.
3. gargle tablet as claimed in claim 1 or 2, it is characterized in that: the disintegrating agent is selected from dried starch, carboxymethyl starch
Sodium, microcrystalline cellulose, low-substituted hydroxypropyl cellulose, croscarmellose sodium, in crospovidone one or two with
On；Preferably, the disintegrating agent is crospovidone.
4. gargle tablet as claimed in claim 1 or 2, it is characterized in that: the carbonate and/or bicarbonate are selected from carbonic acid
It is sodium, potassium carbonate, sodium bicarbonate, saleratus, one or more kinds of in calcium carbonate；Preferably, the bicarbonate is carbon
Sour hydrogen sodium.
5. gargle tablet as claimed in claim 1 or 2, it is characterized in that: the sour agent is selected from organic acid；Preferably, described
Sour agent is one or more kinds of in citric acid, tartaric acid, hexanedioic acid, malic acid, fumaric acid；Preferably, the sour agent
For citric acid.
6. gargle tablet as described in claim 1, it is characterized in that: the active constituent satisfaction with oral cavity fresh and cool effect is following
At least one of:
Sub- Elsholtzia rugulosa Hemsl. is pulled out selected from the plant of integration of drinking and medicinal herbs and/or its extract, open country and/or it is mentioned
Take object；
Preferably, the plant of the integration of drinking and medicinal herbs is one or more kinds of in lily, peppermint, Siraitia grosvenorii, chrysanthemum；
Preferably, it is branch and/or leaf that the medicinal part of son is pulled out in the open country.
7. gargle tablet as claimed in claim 6, it is characterized in that: the active constituent satisfaction with oral cavity fresh and cool effect is following
At least one of:
It is water extract that seed extract is pulled out in open country；
Pull out seed extract and be prepared by the following method to obtain in open country: open country being taken to pull out son, the water of 30 times of quality is added, in 60 DEG C decoct 3 times, often
Secondary 1h merges 3 decoction liquors, concentration, it is dry to get；
Preferably, dry use is spray-dried；
Preferably, the wild condition for pulling out seed extract spray drying are as follows: charging rate 5mL/min, inlet air temperature are 100 DEG C, out
Air temperature is 90 DEG C, and blower frequency is 90m3/ h, atomizing pressure 0.2MPa；
Preferably, wild to pull out seed extract accounts for sheet weight of gargling 5~20%；
It is further preferred that wild pull out seed extract accounts for sheet weight of gargling 10%；
Bulbus Lilii extract is water extract；
Bulbus Lilii extract is prepared by the following method to obtain: taking lily, the water of 10 times of weight is added, decoct 3 times, each 1h, merge 3
Secondary decoction liquor, concentration, it is dry to get；
Preferably, dry use is spray-dried；
Preferably, the condition of Bulbus Lilii extract spray drying are as follows: charging rate 15mL/min, inlet air temperature are 180 DEG C, outlet air
Temperature is 90 DEG C, and blower frequency is 100m3/ h, atomizing pressure 0.2MPa；
Preferably, Bulbus Lilii extract accounts for the 10~30% of sheet weight of gargling；
It is further preferred that Bulbus Lilii extract accounts for the 20% of sheet weight of gargling.
8. gargle tablet as described in claim 1, it is characterized in that: the filler is selected from starch, sucrose, lactose, pregelatinated
It is starch, microcrystalline cellulose, inorganic salts, one or more kinds of in sugar alcohol；Preferably, the filler is xylitol.
9. gargle tablet as described in claim 1, it is characterized in that: meeting at least one of following:
Also containing auxiliary material one or more kinds of in wetting agent, adhesive, lubricant；
Preferably, the wetting agent is selected from or mixtures thereof water, ethyl alcohol；
Preferably, the adhesive is one or two kinds of in povidone, hydroxypropyl methylcellulose, carmethose, syrup
More than；
Preferably, the lubricant accounts for the 1~3% of sheet weight of gargling；
It is further preferred that the lubricant accounts for the 2% of sheet weight of gargling；
Preferably, the lubricant is one or two kinds of in Macrogol 6000, talcum powder, magnesium stearate, superfine silica gel powder
More than；
It is further preferred that the lubricant is Macrogol 6000.
10. the adjuvant composition of speeding up disintegration of tablet, it is characterized in that: containing disintegrating agent, carbonate and/or bicarbonate and acid
Agent.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201910693815.5A CN110251444A (en) | 2019-07-30 | 2019-07-30 | The gargle tablet of easy disintegrating |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201910693815.5A CN110251444A (en) | 2019-07-30 | 2019-07-30 | The gargle tablet of easy disintegrating |
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| CN110251444A true CN110251444A (en) | 2019-09-20 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115093859A (en) * | 2022-05-05 | 2022-09-23 | 朱贵远 | Sodium polyacrylate anti-splash preparation and preparation method thereof |
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| CN101690720A (en) * | 2009-10-14 | 2010-04-07 | 西南大学 | Carteolol orally disintegrating tablets and preparation method thereof |
| CN106727268A (en) * | 2017-02-22 | 2017-05-31 | 云南白药集团股份有限公司 | Oral disnitegration tablet and preparation method thereof |
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| CN115093859A (en) * | 2022-05-05 | 2022-09-23 | 朱贵远 | Sodium polyacrylate anti-splash preparation and preparation method thereof |
| CN115093859B (en) * | 2022-05-05 | 2024-03-01 | 朱贵远 | Sodium polyacrylate splash-proof preparation and preparation method thereof |
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