CN110279436A - A kind of microecology in vaginas sample harvester - Google Patents
A kind of microecology in vaginas sample harvester Download PDFInfo
- Publication number
- CN110279436A CN110279436A CN201910233034.8A CN201910233034A CN110279436A CN 110279436 A CN110279436 A CN 110279436A CN 201910233034 A CN201910233034 A CN 201910233034A CN 110279436 A CN110279436 A CN 110279436A
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- China
- Prior art keywords
- vaginas
- microecology
- sampling
- wraping plate
- sleeve
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 210000001215 vagina Anatomy 0.000 title claims abstract description 38
- 238000005070 sampling Methods 0.000 claims abstract description 53
- 241001391944 Commicarpus scandens Species 0.000 claims description 8
- 241000669069 Chrysomphalus aonidum Species 0.000 claims description 5
- 244000005700 microbiome Species 0.000 abstract description 6
- 210000004400 mucous membrane Anatomy 0.000 abstract 1
- 238000000034 method Methods 0.000 description 9
- 229920000742 Cotton Polymers 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 238000003780 insertion Methods 0.000 description 4
- 230000037431 insertion Effects 0.000 description 4
- 206010046914 Vaginal infection Diseases 0.000 description 3
- 201000008100 Vaginitis Diseases 0.000 description 3
- 210000003679 cervix uteri Anatomy 0.000 description 3
- 208000035475 disorder Diseases 0.000 description 3
- 239000002504 physiological saline solution Substances 0.000 description 3
- 230000000694 effects Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000000149 penetrating effect Effects 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- 108020004465 16S ribosomal RNA Proteins 0.000 description 1
- 208000030507 AIDS Diseases 0.000 description 1
- 206010063409 Acarodermatitis Diseases 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 208000016908 Female Genital disease Diseases 0.000 description 1
- 208000029082 Pelvic Inflammatory Disease Diseases 0.000 description 1
- 208000006399 Premature Obstetric Labor Diseases 0.000 description 1
- 206010036600 Premature labour Diseases 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 241000447727 Scabies Species 0.000 description 1
- 241000973497 Siphonognathus argyrophanes Species 0.000 description 1
- 208000006374 Uterine Cervicitis Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 206010008323 cervicitis Diseases 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000012268 genome sequencing Methods 0.000 description 1
- 210000004379 membrane Anatomy 0.000 description 1
- 210000003097 mucus Anatomy 0.000 description 1
- 238000011017 operating method Methods 0.000 description 1
- 238000009595 pap smear Methods 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 208000026440 premature labor Diseases 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 208000005687 scabies Diseases 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000012163 sequencing technique Methods 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 208000019206 urinary tract infection Diseases 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
- 210000003905 vulva Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/0045—Devices for taking samples of body liquids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/0045—Devices for taking samples of body liquids
- A61B2010/0074—Vaginal or cervical secretions
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Hematology (AREA)
- Pathology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Surgical Instruments (AREA)
Abstract
The present invention discloses a kind of microecology in vaginas sample harvester, including successively matching the outer tube worn, middle sleeve, inner sleeve and sampling rod from outside to inside.Its structure is simple, and can quick assembling, facilitate acquisition.The collector that can precisely acquire vagina middle section Tiny ecosystem sample is formed by the connection of each component matching, institute's collect specimen not will receive the pollution of introitus and cervical orifice microorganism, and will not injured patient's cervical mucous membrane tissue.
Description
Technical field
The present invention relates to a kind of sample collecting apparatus, especially a kind of microecology in vaginas sample harvester.
Background technique
Vaginitis is women Common Gynecologic Diseases, disease incidence about 40~50%.Vaginitis common sympton mainly has vagina scabies
Itch, pain, secretion increase and are in foul smell.In addition, it can also make patient that urinary tract infections, cervicitis, premature labor, pelvic inflammatory disease occur
Increase with the probability of AIDS.
With the development of sequencing technologies, microecology in vaginas disorder has been considered as one of pathogenesis of vaginitis.It determines
The condition whether patient occurs microecology in vaginas disorder is acquisition patient's microecology in vaginas sample, then passes through 16S rDNA high pass
Amount or genome sequencing technology are bound.Therefore, judge whether patient occurs the premise of Tiny ecosystem disorder and seek to acquire
To the sample of authentic representative microecology in vaginas.
Currently, clinically the method and its shortcoming of acquisition microecology in vaginas sample are as follows:
First method: soaking aseptic cotton carrier using physiological saline, cotton swab is then protruded into vagina rotating middle part, then cotton swab is taken
It is placed in physiological saline Restored in test tube out.The shortcoming of the method is: cotton swab will receive the pollution of introitus microorganism, therefore institute
The sample of acquisition can not represent microecology in vaginas completely.
Second method: protruding into vagina using vaginal dilator, then using the secretion of aseptic cotton carrier acquisition cervix opening, by cotton
Label merging physiological saline Restored in test tube.The shortcoming of the method is: sample is only capable of representing uterine neck Tiny ecosystem, cannot but represent yin
Road Tiny ecosystem.However, some researches show that uterine neck Tiny ecosystems different from microecology in vaginas.So vaginal dilator sampling method is not
It is suitble to detection patient's microecology in vaginas.
Therefore, in order to collect the sample of authentic representative microecology in vaginas, it need to develop and a kind of both be avoided that the micro- life of vulva mouth
Object pollution, and the acquisition instrument of mucus in the middle part of vagina can be collected.
Summary of the invention
To solve the above-mentioned problems, the present invention provides a kind of microecology in vaginas sample harvester, and structure is simple, operation side
It just, can be with the microorganism sample in the middle part of precise acquisition vagina.
To realize above-mentioned technical purpose and the technique effect, the present invention is achieved by the following technical solutions: one
Kind microecology in vaginas sample harvester, including successively matching the outer tube worn, middle sleeve, inner sleeve and sampling from outside to inside
Stick is equipped with the stretching that middle sleeve opening is convenient for middle sleeve in the left end of outer tube, is equipped with resistive force sensor, the right side in middle sleeve left end
End is equipped with warning lamp, and the resistive force sensor and warning lamp are electrically connected, the sampling rod include the main paragraph being threadedly coupled and
Sampling head, the inner hollow and right openings of sampling head are equipped with the wraping plate of longitudinal sliding mouth and its bottom in sampling head left end
Extending port connection, the width of wraping plate extending port are less than the width of sliding mouth, sliding slot are respectively equipped in sliding mouth two sides, in sliding mouth
Interior to be equipped with sliding block, the sliding block can move up and down along the chute, sampling swab be connected by connecting rod on the lateral surface of sliding block, in master
A longitudinally-moving slot is equipped in body section, loose slot extends along the length direction of main paragraph, and one piece of tilting is equipped in the middle part of loose slot
Supporting plate is equipped with a wraping plate perforation for penetrating through its left and right sides in the middle part of tilting supporting plate, and wraping plate left end penetrates on the right side of loose slot
And sequentially pass through wraping plate perforation and wraping plate extending port and be placed below sliding shoe, inner sleeve tube opening is equipped on interior casing wall,
Position corresponding with inner sleeve tube opening is open equipped with middle sleeve on middle sleeve wall, and the length of middle sleeve is set as 12 cm, middle sleeve
Opening is located at the position away from middle sleeve left end 5cm.
Further, ring wall is equipped with collar stop to resist inner sleeve right side on the right side of sampling rod, sampling swab with it is interior
Casing left end inner wall does not contact always.
Further, labeled slots one, two and of labeled slots are respectively equipped on the right side of sampling rod, inner sleeve and middle sleeve
Labeled slots three, after the assembly is completed, labeled slots one, labeled slots two and labeled slots three are aligned collector, at this time inner sleeve tube opening, middle set
Tube opening and sampling swab position are corresponding.
Further, circular scale is equipped on outer casing wall and is equipped with stop collar in outer tube right end, stop collar it is outer
Diameter is greater than the caliber of outer tube to keep stop collar to be constantly in outside introitus.
Further, it is equipped with limited block in wraping plate right-hand end, the width that the width of limited block is greater than loose slot avoids wraping plate
All protruding into influences operation by human hand in loose slot.
Further, it is equipped with place easy to break on the right side of sampling head and is located at fractureing for place's left part easy to break convenient for sampling head.
The beneficial effects of the present invention are:
Microecology in vaginas sample harvester structure disclosed by the invention is simple, easy to use, can be with precise acquisition vagina in the middle part of
Tiny ecosystem sample;Institute's collect specimen not will receive the pollution of introitus and cervical orifice microorganism;And it will not injured patient uterus
Neck stick membrane tissue.
Detailed description of the invention
Fig. 1 is a kind of schematic front view of microecology in vaginas sample harvester disclosed by the invention;
Fig. 2 is the schematic front view of sampling rod disclosed by the invention;
Fig. 3 is the left view schematic diagram of sampling head disclosed by the invention;
Fig. 4 is a kind of right side view of microecology in vaginas sample harvester disclosed by the invention.
Wherein, 1- outer tube, 2- middle sleeve, 3- inner sleeve, 4- sampling rod, 5- middle sleeve opening, 6- resistive force sensor, 7-
Warning lamp, 8- main paragraph, 9- sampling head, 10- slide mouth, 11- wraping plate extending port, 12- sliding block, 13- sampling swab, 14- activity
Slot, 15- tilting supporting plate, the perforation of 16- wraping plate, 17- wraping plate, 18- inner sleeve tube opening, 19- middle sleeve opening, 20- collar stop,
21- labeled slots one, 22- labeled slots two, 23- labeled slots three, 24- circular scale, 25- limited block, the place easy to break 26-.
Specific embodiment
The preferred embodiments of the present invention will be described in detail by 1-4 with reference to the accompanying drawing, so that advantages of the present invention and spy
Sign can be easier to be readily appreciated by one skilled in the art, so as to make a clearer definition of the protection scope of the present invention.
In order to acquire dirt of the vagina middle section Tiny ecosystem sample to avoid sample by introitus and cervical orifice microorganism
Dye, the present invention discloses a kind of microecology in vaginas sample harvester, including successively matching the outer tube 1 worn, middle set from outside to inside
Pipe 2, inner sleeve 3 and sampling rod 4 are equipped with the stretching that middle sleeve opening 5 is convenient for middle sleeve 2 in the left end of outer tube 1, in middle sleeve
2 left ends are equipped with resistive force sensor 6, right end is equipped with warning lamp 7, and the resistive force sensor 6 and warning lamp 7 are electrically connected.
The sampling rod 4 includes the main paragraph 8 and sampling head 9 being threadedly coupled, the inner hollow and right side opening of sampling head 9
Mouthful, longitudinal sliding mouth 10, which is equipped with, in 9 left end of sampling head is connected to the wraping plate extending port 11 of its bottom, the width of wraping plate extending port 11
Degree is less than the width of sliding mouth 10, is respectively equipped with sliding slot in sliding 10 two sides of mouth, is equipped with sliding block 12, the cunning in sliding mouth 10
Block 12 10 can move up and down along the chute, connect sampling swab 13 by connecting rod on the lateral surface of sliding block 12, set in main paragraph 8
There is a longitudinal loose slot 14, loose slot 14 extends along the length direction of main paragraph 8, and one piece of tilting is equipped in the middle part of loose slot 14
Supporting plate 15 is equipped with a wraping plate perforation 16 for penetrating through its left and right sides in the middle part of tilting supporting plate 15, and 17 left end of wraping plate is from loose slot
14 right sides penetrate and sequentially pass through wraping plate perforation 16 and wraping plate extending port 11 is placed on 12 lower section of sliding shoe, on 3 wall of inner sleeve
Equipped with inner sleeve tube opening 18, position corresponding with inner sleeve tube opening 18 is equipped with middle sleeve opening 19, Nv Xingyin on 2 wall of middle sleeve
The length in road is about 9-10 cm, to guarantee that 2 outboard end of middle sleeve is in outside introitus always in use process, the length of middle sleeve 2
Degree is set as 12 cm, and middle sleeve opening 19 is located at the position away from 2 left end of middle sleeve, 5 cm, and middle sleeve 2 therefrom covers after protruding into vagina
The sampling swab 13 that tube opening 19 stretches out can collect the Tiny ecosystem sample in vagina middle section.
Collar stop 20 is equipped in 4 right side ring wall of sampling rod to resist 3 right side of inner sleeve, sampling swab 13 and inner sleeve
3 left end inner walls do not contact always.
Labeled slots 1, labeled slots 2 22 and mark are respectively equipped on the right side of sampling rod 4, inner sleeve 3 and middle sleeve 2
Remember slot 3 23, after the assembly is completed, labeled slots 1, labeled slots 2 22 and labeled slots 3 23 are aligned collector, and inner sleeve is opened at this time
Mouth 18, middle sleeve opening 19 and 13 position of sampling swab are corresponding.
Circular scale 24 is equipped on 1 wall of outer tube so that operator can be clear from outer tube 1 from all angles
The amount of protruding into, and be equipped with stop collar in 1 right end of outer tube, the outer diameter of stop collar is greater than the caliber of outer tube to keep stop collar one
Directly outside introitus, the setting stop collar person of being convenient to operation is inserted into defensive position in outer tube 1 and handles the stabilized outer tube 1 of stop collar
Position with carry out middle sleeve 2 insertion etc. subsequent operations, for the ease of the insertion and extraction of middle sleeve 2, on the right side of middle sleeve 2
End may also set up an annular stop annulus.
It is equipped with limited block 25 in 17 right-hand end of wraping plate, the width that the width of limited block 25 is greater than loose slot 14 avoids wraping plate 17
All protruding into influences operation by human hand in loose slot 14.
It is equipped with place 26 easy to break on the right side of sampling head 9 and is located at fractureing for 26 left part of place easy to break convenient for sampling head 9.
Specific operating method are as follows: patient lies on examination couch, and operator keeps labeled slots upward after assembling collector
And a finger resists wraping plate 17 and makes it with contacting at the top of loose slot 14 to guarantee that sampling swab 13 is in sliding groove bottommost, it
Outer tube 1 is inserted into patient's vagina afterwards, insertion depth is judged according to the circular scale 24 on outer tube 1, when being inserted into 1 ~ 1.5 cm
Stop insertion, backward intravaginal propulsion middle sleeve 2, when resistive force sensor receives the resistance signal from cervix, about
(Resistance Value for reaching cervical orifice uses vaginal dilator measured when carrying out cervical screening from 100 women when 0.8 N
0.8 N of average value), warning lamp 7 flashes, and operator knows that 2 front end of middle sleeve has been approached cervical orifice, stops middle sleeve 2 at this time
Continue protrude into, stir wraping plate 17 downwards, using lever principle make sampling swab 13 along sliding groove move upwards successively stretch out in
It is contacted after casing sample tap 18 and middle sleeve sample tap 19 with the inner wall in vagina middle section, keeps 17 position of wraping plate motionless, in rotation
The circle of casing 2 three completes sampling, withdraws from wraping plate 17 outward later, and sliding block 12 glides along sliding groove under the action of losing and shoring power and receives
It returns in inner sleeve 3, takes out collector later, sampling rod 4 is taken out from inner sleeve 3, sampling head 9 is fully recessed into sample and holds appearance
After device, 26 firmly roll over sampling head 9 in test tube mouth from easy to break, and place 26 easy to break just will disconnect, and can make sampling head 9 and main paragraph
8 separation make sampling swab 13 fall completely within test tube, and will not fall into test tube, i.e. operator at the hand-held sampling rod of operator
Bacterium on hand will not pollute sample.The sampling for the vagina middle section sample completed using the collector not will receive introitus and son
The reliability of the pollution of cervix opening microorganism, testing result is higher.
The above description is only an embodiment of the present invention, is not intended to limit the scope of the invention, all to utilize this hair
Equivalent structure or equivalent flow shift made by bright specification and accompanying drawing content is applied directly or indirectly in other relevant skills
Art field, is included within the scope of the present invention.
Claims (6)
1. a kind of microecology in vaginas sample harvester, which is characterized in that including successively matching the outer tube worn from outside to inside
(1), middle sleeve (2), inner sleeve (3) and sampling rod (4) are equipped with middle sleeve opening (5) in the left end of outer tube (1), in middle set
It manages (2) left end and is equipped with resistive force sensor (6), right end equipped with warning lamp (7), the resistive force sensor (6) and warning lamp (7) are electrically
Connection;The sampling rod (4) includes the main paragraph (8) and sampling head (9) being threadedly coupled, the inner hollow of sampling head (9) and the right side
Side opening is equipped with longitudinal sliding mouth (10) in sampling head (9) left end and is connected to the wraping plate extending port (11) of its bottom, and wraping plate is stretched
The width for exporting (11) is less than the width of sliding mouth (10), sliding slot is respectively equipped in sliding mouth (10) two sides, in sliding mouth (10)
Interior to be equipped with sliding block (12), the sliding block (12) (10) can move up and down along the chute, pass through connecting rod on the lateral surface of sliding block (12)
It connects sampling swab (13), a longitudinal loose slot (14) is equipped in main paragraph (8), loose slot (14) is along main paragraph (8)
Length direction extends, and one piece of tilting supporting plate (15) is equipped in the middle part of loose slot (14), is equipped in the middle part of tilting supporting plate (15) consistent
Lead to the wraping plate perforation (16) of its left and right sides, wraping plate (17) left end penetrates on the right side of loose slot (14) and sequentially passes through wraping plate and wears
Hole (16) and wraping plate extending port (11) are placed below sliding shoe (12), are equipped with inner sleeve tube opening (18) on interior casing wall,
Position corresponding with inner sleeve tube opening (18) is equipped with middle sleeve opening (19), the length setting of middle sleeve (2) on middle sleeve (2) wall
For 12 cm, middle sleeve opening (19) is located at the position away from 5 cm of middle sleeve (2) left end.
2. a kind of microecology in vaginas sample harvester as described in claim 1, which is characterized in that the ring on the right side of sampling rod (4)
Wall is equipped with collar stop (20) to resist inner sleeve (3) right side, and sampling swab (13) and inner sleeve (3) left end inner wall are always not
Contact.
3. a kind of microecology in vaginas sample harvester as claimed in claim 2, which is characterized in that in sampling rod (4), inner sleeve
(3) and on the right side of middle sleeve (2) labeled slots one (21), labeled slots two (22) and labeled slots three (23) are respectively equipped with, are acquired
Device after the assembly is completed, labeled slots one (21), labeled slots two (22) and labeled slots three (23) alignment, at this time inner sleeve tube opening (18),
Middle sleeve opening (19) is corresponding with sampling swab (13) position.
4. a kind of microecology in vaginas sample harvester as described in claim 1, which is characterized in that set on outer tube (1) wall
Have circular scale (24), and be equipped with stop collar in outer tube (1) right end, the outer diameter of stop collar is greater than the caliber of outer tube to keep
Stop collar is constantly in outside introitus.
5. a kind of microecology in vaginas sample harvester as described in claim 1, which is characterized in that in wraping plate (17), right-hand end is set
Have limited block (25), the width that the width of limited block (25) is greater than loose slot (14) avoids wraping plate (17) from all protruding into loose slot
(14) operation by human hand is influenced in.
6. a kind of microecology in vaginas sample harvester as described in claim 1, which is characterized in that set on the right side of sampling head (9)
There are place easy to break (26).
Priority Applications (1)
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CN201910233034.8A CN110279436B (en) | 2019-03-26 | 2019-03-26 | Vaginal microecological specimen collector |
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CN201910233034.8A CN110279436B (en) | 2019-03-26 | 2019-03-26 | Vaginal microecological specimen collector |
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CN110279436B CN110279436B (en) | 2023-12-29 |
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CN2275431Y (en) * | 1996-10-11 | 1998-03-04 | 湖南医科大学附属第三医院 | Fast single-hand biopsy gun |
US6302853B1 (en) * | 2000-02-24 | 2001-10-16 | R & G Medical And Development Corp. | Method and apparatus for sampling cervical tissue |
CN101879079A (en) * | 2010-06-30 | 2010-11-10 | 中国人民解放军第三军医大学第一附属医院 | Biopsy needle |
CN103690306A (en) * | 2014-01-07 | 2014-04-02 | 魏永祥 | Specimen sampling swab |
CN107843587A (en) * | 2017-12-14 | 2018-03-27 | 徐州市永康电子科技有限公司 | A kind of Novel gynecology-department inflammation test bar |
CN207444962U (en) * | 2017-03-23 | 2018-06-05 | 张永涛 | Gynemetrics's vaginal fluid sampling device |
CN108283507A (en) * | 2018-01-23 | 2018-07-17 | 孙平 | A kind of vaginal fluid sampling device for gynemetrics's clinic |
CN210019433U (en) * | 2019-03-26 | 2020-02-07 | 江南大学 | Microecological sample collector for vagina |
-
2019
- 2019-03-26 CN CN201910233034.8A patent/CN110279436B/en active Active
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN2275431Y (en) * | 1996-10-11 | 1998-03-04 | 湖南医科大学附属第三医院 | Fast single-hand biopsy gun |
US6302853B1 (en) * | 2000-02-24 | 2001-10-16 | R & G Medical And Development Corp. | Method and apparatus for sampling cervical tissue |
CN101879079A (en) * | 2010-06-30 | 2010-11-10 | 中国人民解放军第三军医大学第一附属医院 | Biopsy needle |
CN103690306A (en) * | 2014-01-07 | 2014-04-02 | 魏永祥 | Specimen sampling swab |
CN207444962U (en) * | 2017-03-23 | 2018-06-05 | 张永涛 | Gynemetrics's vaginal fluid sampling device |
CN107843587A (en) * | 2017-12-14 | 2018-03-27 | 徐州市永康电子科技有限公司 | A kind of Novel gynecology-department inflammation test bar |
CN108283507A (en) * | 2018-01-23 | 2018-07-17 | 孙平 | A kind of vaginal fluid sampling device for gynemetrics's clinic |
CN210019433U (en) * | 2019-03-26 | 2020-02-07 | 江南大学 | Microecological sample collector for vagina |
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