CN110278945A - A kind of slow-release dry suspending agent and preparation method thereof containing Fluoxastrobin and Tebuconazole - Google Patents
A kind of slow-release dry suspending agent and preparation method thereof containing Fluoxastrobin and Tebuconazole Download PDFInfo
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- CN110278945A CN110278945A CN201910587477.7A CN201910587477A CN110278945A CN 110278945 A CN110278945 A CN 110278945A CN 201910587477 A CN201910587477 A CN 201910587477A CN 110278945 A CN110278945 A CN 110278945A
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- tebuconazole
- dry suspending
- suspending agent
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/12—Powders or granules
- A01N25/14—Powders or granules wettable
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
- A01N43/36—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom five-membered rings
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/54—1,3-Diazines; Hydrogenated 1,3-diazines
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
- A01N43/647—Triazoles; Hydrogenated triazoles
- A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
Abstract
The present invention provides a kind of slow-release dry suspending agent containing Fluoxastrobin and Tebuconazole, and the dry suspending agent is hollow beads shape dry suspending agent, has slow release effect, include: effective component 10-90wt%, wetting agent 1-10 wt %, dispersing agent 5-25wt%, binder 1-5wt%, bleeding agent 1-5 wt %, disintegrating agent 1-20wt%, defoaming agent 0.1-3wt%, grinding aid 0.1-5wt%, stabilizer 1-5wt%, filler complement to 100wt%；The effective component be Fluoxastrobin and Tebuconazole, lincomycin, Fluoxastrobin, Tebuconazole, lincomycin weight ratio be 1-80:1-80:0.1-0.3.Dry suspending agent of the invention, using Fluoxastrobin and Tebuconazole as main component, using lincomycin as synergistic component, while improving bactericidal effect, broad-spectrum and sterilization duration, it is possible to reduce formulation rate improves the service life of drug.
Description
Technical field
The present invention relates to pesticide production technology fields, and in particular to a kind of slow-release containing Fluoxastrobin and Tebuconazole is dry to suspend
Agent and preparation method thereof.
Background technique
Fluoxastrobin, English name Azoxystrobin, Chinese nickname (E)-[2- [6- (2- cyano-benzene oxygen) pyrimidine-4-yl
Oxygen] phenyl] -3- methoxy-methyl acrylate, chemical formula C22H17N3O5, Fluoxastrobin is that new and effective, wide spectrum, absorbability are killed
Microbial inoculum.It can be used for that cauline leaf is spraying, seed treatment, scholar's earth processing can also be carried out.It is to nearly all Mycophytes (Ascomycetes, load
Daughter bacteria guiding principle, Oomycete and Fungi Imperfecti) disease, such as powdery mildew, rust, the withered lame, net blotch of grain husk, downy mildew, rice blast has
Good activity, and have fungicide no interactions resistance with current.For cereal, rice, grape, potato, vegetables, fruit tree and
Other crops, to these crop safeties.
Tebuconazole, English name Tebuconazole, Chinese nickname 1- (4- chlorphenyl) -4,4- dimethyl -3- (1H-1,
2,4- triazol-1-yl methyl) amyl- 3- alcohol, chemical formula C16H22ClN3O, Tebuconazole be it is a kind of efficiently, wide spectrum, absorbability three
Azole sterilization pesticide is able to suppress the biosynthesis of the ergosterol of fungi as all triazole bactericidal agents.With guarantor
It protects, treat, rooting out three zones, wide sterilization spectrum, lasting period are long.
Dry suspending agent, dry suspending agent are a kind of hollow beads shape formulations of pesticide products, are after suspending agent in content, packet
Dress, technique, cost, quality stability, the renewal product for being significantly better than using technology various aspects other dosage forms.It is dry outstanding
Floating agent is suspension before drying-granulating, and becomes solid particulate state after spray drying granulation；It is dilute with water when in use
Suspension is released and reverts to, the solid pesticide particle for being 1-10 μm using partial size is dispersed phase, using water as the dispersion of continuous phase
System.The series of advantages such as the partial size that there is dry suspending agent suspending agent to have is small, and active area is big, and suspensibility high-drug-effect is good, together
When have good physical storage stability, convenient transportation, storage, it is small to the pollution pressure of environment.
Summary of the invention
The present invention provides a kind of preparation method of slow-release dry suspending agent containing Fluoxastrobin and Tebuconazole, the purpose of the present invention
It is to provide a kind of slow-release dry suspending agent containing Fluoxastrobin and Tebuconazole to mention using Fluoxastrobin and Tebuconazole as main component
While high bactericidal effect, broad-spectrum and sterilization duration, it is possible to reduce formulation rate, that improves drug uses the longevity
Life.
The present invention provides the preparation processes of this kind of dry suspending agent.
The present invention also provides application of this kind of fungicide in prevention and treatment rice sheath blight disease, false smut.
In order to achieve the above-mentioned object of the invention, The technical solution adopted by the invention is as follows:
A kind of slow-release dry suspending agent containing Fluoxastrobin and Tebuconazole, it is characterised in that: the dry suspending agent is hollow beads shape
Dry suspending agent has slow release effect, includes: effective component 10-90wt%, wetting agent 1-10 wt %, dispersing agent 5-25wt% glue
Tie agent 1-5wt%, bleeding agent 1-5 wt %, disintegrating agent 1-20wt%, defoaming agent 0.1-3wt%, grinding aid 0.1-5wt%, stabilizer
1-8wt%, filler complement to 100wt%；The effective component is Fluoxastrobin and Tebuconazole, and the weight ratio of lincomycin, three is
1-80:1-80:0.1-0.3；.
Further, the active constituent content is 10-90wt%, the preferably 50%-80wt% of fungicide, most preferably
60-80wt%。
Further, the stabilizer includes: xanthan gum and polyvinyl alcohol, cyclodextrin, carboxymethyl cellulose, carboxylic first
One of base sodium starch, modification of chitosan or more than one.
Further, dispersing agent is lignosulfonates or naphthalene sulfonate and polycarboxylate.
Further, binder is straight chain corn starch.
The slow-release dry suspending agent containing Fluoxastrobin and Tebuconazole answers the banded sclerotial blight of rice, the prevention and treatment of false smut
With.
A kind of preparation method of the slow-release dry suspending agent containing Fluoxastrobin and Tebuconazole, which is characterized in that including following step
It is rapid: (1) the 50% of the total component of pre-add water Zhan in the kettle that feeds intake, by solid press wetting agent, dispersing agent, binder, defoaming agent, effectively at
Point, grinding aid, disintegrating agent, the filler shearing in kettle that feeds intake in order is recycled to homogeneously；
(2) material sheared is sanded by sand mill to partial size d98≤5 μm, the material after sand milling, which is put into finished product kettle, to be held
Continuous stirring, is added stabilizer, continues to stir evenly；
(3) spray dryer preheating makes inlet air temperature reach 110 DEG C, and leaving air temp reaches 60 DEG C, after material is filtered,
Material is delivered to tower top with given pace by high-pressure pump, material is atomized into droplet by tower top atomizer, after drying, directly
It connects to obtain the dry suspending agent particle of internal defect, it is screened to obtain finished product dry suspending agent later.
The dry suspending agent, preparation method be first pass through that wet-milling is broken to be processed into suspended substance, then by spray drying plus
Work is at hollow beads shape finished product.
The fungicide, prevention and treatment crop are rice, peanut, banana.
The fungicide shows banded sclerotial blight, false smut to the application effect of rice.
The beneficial effects of the present invention are:
For the present invention using Fluoxastrobin and Tebuconazole as effective active composition, lincomycin being capable of effectively preventing water as promotor
The banded sclerotial blight of rice, false smut, wherein lincomycin has the effect of synergy.
After wet type is sanded, it is added some such as polyvinyl alcohol, carboxymethyl cellulose in the slurry, a kind of steady of cyclodextrin
Determine agent, is uniformly mixed with slurry.In dry spray process, small-molecular-weight auxiliary agent can be formed with surfactant in droplet surface
One liquid film, after droplet drying, liquid film drying and dehydrating therewith is coated on bead surface and forms a small shell.Biggish particle by
Coated in liquid film relatively thin, dry vapor is escaped by bead surface when spraying to form that gap is larger, and bead collapses after adding water to apply
Solution dispersion, pesticide active ingredient directly work in reaching sterilization protecting effect on plant；Lesser bead shell wall is thicker, will be effective
Ingredient is coated on inside shell, adds effective component slow release after water, reaches long-acting protection bactericidal effect.The effect of sustained release with plus
The auxiliary agent type entered, dry suspending agent active constituent content, the factors such as dry spray droplet size are related.The promoter addition of shelling
Few, water-soluble strong, drop is big, and effective component largely suspends in water, and slow release effect is general, is suitable for directly sterilizing.Shelling
Promoter addition is big, and formation drop is small, and this finished product onset time is long, is suitable for protective fungicide.
Detailed description of the invention
Fig. 1 is dry suspending agent typical process flow figure.
Specific embodiment
Present invention will be further explained below with reference to specific examples.It should be understood that these embodiments are merely to illustrate this hair
It is bright, rather than limit the scope of the invention.Under the premise of without departing substantially from technical solution of the invention, the present invention is made
Those of ordinary skill in the art's any change easy to accomplish fall within scope of the presently claimed invention.
It the use of drying instruments is that domestic more universal press spray is dry by taking+50% Tebuconazole DF of 25% Fluoxastrobin as an example
Dry device, preparation method are as follows:
Solid is pressed wetting agent by the 50% of the total component of pre-add water Zhan in kettle of feeding intake, bleeding agent, dispersing agent, binder, and defoaming agent has
Imitate ingredient, grinding aid, disintegrating agent, the filler shearing in kettle that feeds intake in order is recycled to homogeneously.In solid, Fluoxastrobin effectively at
Point accounting 25%, Tebuconazole effective component accounting 50%, lincomycin accounting 0.1-0.3%, wetting agent neopelex add
Enter 2%, dispersing agent is sodium lignin sulfonate 8%, polycarboxylate 3%, organic silicon defoamer 0.5%, grinding aid magnesium stearate accounting
0.5%, disintegrating agent ammonium sulfate accounting 2%, binder straight chain corn starch 3%, filler is that anhydrous sodium sulphate supplies about 6%.
The material sheared is sanded by sand mill to partial size d98≤5 μm, the material after sand milling, which is put into finished product kettle, to be held
It is equal to continue stirring for continuous stirring, addition stabilizer polyvinyl alcohol 2%, cyclodextrin 2%, xanthan gum 0.15%, carboxymethyl cellulose 0.5%
It is even.
Spray dryer preheating makes inlet air temperature reach 110 DEG C, and leaving air temp reaches 65 DEG C, and material is filtered
Afterwards, material is delivered to given pace by tower top by high-pressure pump, material is atomized into droplet by tower top atomizer, surface it is small
Molecular weight auxiliary agent forms a thin layer of liquid film by intermolecular interaction, and the heated rear surface moisture of droplet evaporates rapidly,
Liquid film is coated on half-dried bead surface after drying out.Bead internal moisture is by gap, constantly to external migration to supplement surface
Moisture, outer surface quickly form half stem body, and internal moisture is obstructed slack-off to external migration.As particle temperature rises, internal moisture
It begins vaporization, gas pressure constantly increases；When reaching certain pressure limit, gas is escaped from particle shell weak part, through dry
After dry, the dry suspending agent particle of internal defect is directly obtained.Starch can be such that droplet forms when dry as binder
The stronger stabilization of grain, when hydrolysis, can also be easier to crack, while have better adhesiveness to plant surface, improve efficiency,
Amylose can be improved porosity when dry simultaneously, and moisture is promoted to leave, and raising forms df rate.It is screened to obtain later
Finished product dry suspending agent.Basic procedure See Figure 1.
1 45% Fluoxastrobin Tebuconazole dry suspending agent of embodiment
Fluoxastrobin 15%, Tebuconazole 30%, lincomycin 0.2%, wetting agent sodium alkyl sulfate 2%, binder straight chain corn starch 3%,
Dispersing agent calcium lignosulfonate 10%, polycarboxylate sodium 10%, defoaming agent 1%, grinding aid magnesium stearate 1%, disintegrating agent urea 10%,
Filler is that anhydrous sodium sulphate complements to 100%, and pre-add water in the kettle that feeds intake (liquid and solids ratios be 1:1), material is added feeds intake in order
Kettle is sheared to homogeneous, is sanded through sand mill to partial size d98≤5 μm and is entered finished product kettle.Stabilizer polyvinyl alcohol is added in finished product kettle
2%, cyclodextrin 2%, xanthan gum 0.3%, carboxymethyl cellulose 0.5% continues to stir evenly.Material is passed by high-pressure pump after filtering
Transport to tower top atomization.Inlet air temperature is set as 120 DEG C, and leaving air temp is set as 60 DEG C, dry in press spray drier
It is screened to obtain 45% Fluoxastrobin Tebuconazole dry suspending agent of finished product at hollow beads shape.
2 50% Fluoxastrobin Tebuconazole dry suspending agent of embodiment
Fluoxastrobin 25%, Tebuconazole 25%, lincomycin 0.1%, wetting agent sodium alkyl sulfonate 1.5%, binder straight chain corn starch
3%, dispersing agent sodium lignin sulfonate 12%, polycarboxylate sodium 8%, defoaming agent 1%, grinding aid magnesium stearate 1%, disintegrating agent ammonium sulfate
10%, filler is that anhydrous sodium sulphate complements to 100%, and pre-add water in the kettle that feeds intake (liquid and solids ratios be 1:1), material is added in order
The kettle that feeds intake is sheared to homogeneous, is sanded through sand mill to partial size d98≤5 μm and is entered finished product kettle.Stabilizer carboxylic first is added in finished product kettle
Base sodium starch 2%, cyclodextrin 1%, xanthan gum 0.3%, modification of chitosan 1.5% continue to stir evenly.Material passes through height after filtering
Press pump is transmitted to tower top atomization.Inlet air temperature is set as 118 DEG C, and leaving air temp is set as 65 DEG C, in press spray drier
It is inside dried to hollow beads shape, it is screened to obtain 50% Fluoxastrobin Tebuconazole dry suspending agent of finished product.
3 55% Fluoxastrobin Tebuconazole dry suspending agent of embodiment
Fluoxastrobin 15%, Tebuconazole 40%, lincomycin 0.3%, wetting agent isopropyl naphthalene sulfonate 1.5%, binder straight-chain maize
Starch 3%, dispersing agent sodium lignin sulfonate 13%, polycarboxylate sodium 10%, defoaming agent 1%, grinding aid magnesium stearate 1%, disintegrating agent urine
Element 5%, filler are that anhydrous sodium sulphate complements to 100%, and pre-add water in the kettle that feeds intake (liquid and solids ratios be 1:1), material adds in order
Enter the kettle that feeds intake to shear to homogeneous, is sanded through sand mill to partial size d98≤5 μm and enters finished product kettle.It is poly- that stabilizer is added in finished product kettle
Vinyl alcohol 4%, cyclodextrin 3%, xanthan gum 0.2%, modification of chitosan 2% continue to stir evenly.Material passes through high-pressure pump after filtering
It is transmitted to tower top atomization.Inlet air temperature is set as 130 DEG C, and leaving air temp is set as 70 DEG C, does in press spray drier
It is dry at hollow beads shape, it is screened to obtain 55% Fluoxastrobin Tebuconazole dry suspending agent of finished product.
4 60% Fluoxastrobin Tebuconazole dry suspending agent of embodiment
Fluoxastrobin 30%, Tebuconazole 30%, lincomycin 0.2%, wetting agent sodium alklyarylsulfonate 2.5%, binder straight-chain maize
Starch 3%, dispersing agent calcium lignosulfonate 8%, polycarboxylate sodium 8%, defoaming agent 1%, grinding aid magnesium stearate 1%, disintegrating agent urea
5%, filler is that calcined kaolin complements to 100%, and pre-add water in the kettle that feeds intake (liquid and solids ratios be 1:1), material is in order
The addition kettle that feeds intake is sheared to homogeneous, is sanded through sand mill to partial size d98≤5 μm and is entered finished product kettle.Stabilizer is added in finished product kettle
Polyvinyl alcohol 1%, cyclodextrin 1%, xanthan gum 0.2%, modification of chitosan 1% continue to stir evenly.Material passes through high pressure after filtering
Pump is transmitted to tower top atomization.Inlet air temperature is set as 105 DEG C, and leaving air temp is set as 68 DEG C, in press spray drier
It is dried to hollow beads shape, it is screened to obtain 60% Fluoxastrobin Tebuconazole dry suspending agent of finished product.
5 60% Fluoxastrobin Tebuconazole dry suspending agent of embodiment
Fluoxastrobin 20%, Tebuconazole 40%, lincomycin 0.2%, 1% anion wetting agent 1% of wetting agent alkylnaphthalene sulfonate, bonding
Agent straight chain corn starch 3%, dispersing agent calcium lignosulfonate 6%, polycarboxylate sodium 6%, defoaming agent 1%, grinding aid magnesium stearate 1%,
Disintegrating agent urea 8%, filler are that calcined kaolin complements to 100%, pre-add water in the kettle that feeds intake (liquid and solids ratios be 1:1),
The kettle that feeds intake is added in order and shears to homogeneous for material, is sanded through sand mill to partial size d98≤5 μm and enters finished product kettle.In finished product kettle
Addition stabilizer polyvinyl alcohol 2%, cyclodextrin 1.5%, xanthan gum 0.2%, modification of chitosan 1% continue to stir evenly.Material passes through
Tower top atomization is transmitted to by high-pressure pump after filter.Inlet air temperature is set as 100 DEG C, and leaving air temp is set as 72 DEG C, in pressure type
Hollow beads shape is dried in spray dryer, it is screened to obtain 60% Fluoxastrobin Tebuconazole dry suspending agent of finished product.
6 60% Fluoxastrobin Tebuconazole dry suspending agent of embodiment
Fluoxastrobin 40%, Tebuconazole 20%, lincomycin 0.2%, 1% anion wetting agent 1% of wetting agent alkylnaphthalene sulfonate, bonding
Agent straight chain corn starch 3%, dispersing agent calcium lignosulfonate 4%, polycarboxylate sodium 8%, defoaming agent 1%, grinding aid magnesium stearate 1%,
Disintegrating agent ammonium sulfate 5%, filler are that calcined kaolin complements to 100%, pre-add water in the kettle that feeds intake (liquid and solids ratios are 1:
1), the kettle that feeds intake is added in order and shears to homogeneous for material, is sanded through sand mill to partial size d98≤5 μm and enters finished product kettle.Finished product kettle
Interior addition stabilizer polyvinyl alcohol 2%, cyclodextrin 1.5%, xanthan gum 0.15%, modification of chitosan 1% continue to stir evenly.Material
Tower top atomization is transmitted to by high-pressure pump after filtering.Inlet air temperature is set as 145 DEG C, and leaving air temp is set as 65 DEG C, is pressing
Hollow beads shape is dried in power formula spray dryer, it is screened to obtain 60% Fluoxastrobin Tebuconazole dry suspending agent of finished product.
7 75% Fluoxastrobin Tebuconazole dry suspending agent of embodiment
Fluoxastrobin 25%, Tebuconazole 50%, lincomycin 0.2%, wetting agent neopelex 2%, binder straight-chain maize
Starch 3%, dispersing agent sodium lignin sulfonate 8%, polycarboxylate sodium 3%, defoaming agent 0.5%, grinding aid magnesium stearate 0.5%, disintegrating agent
Ammonium sulfate 2%, filler are that anhydrous sodium sulphate complements to 100%, and pre-add water in the kettle that feeds intake (liquid and solids ratios be 1:1), material is in due order
The sequence addition kettle that feeds intake is sheared to homogeneous, is sanded through sand mill to partial size d98≤5 μm and is entered finished product kettle.It is added and stablizes in finished product kettle
Agent polyvinyl alcohol 2%, cyclodextrin 2%, xanthan gum 0.15%, carboxymethyl cellulose 0.5% stir evenly.Material passes through after filtering
High-pressure pump is transmitted to tower top atomization.Inlet air temperature is set as 110 DEG C, and leaving air temp is set as 65 DEG C, dry in press spray
Hollow beads shape is dried in device, it is screened to obtain 75% Fluoxastrobin Tebuconazole dry suspending agent of finished product.
8 80% Fluoxastrobin Tebuconazole dry suspending agent of embodiment
Fluoxastrobin 20%, Tebuconazole 60%, lincomycin 0.2%, wetting agent alkyl sulfo succinate 1.5%, binder straight chain are beautiful
Rice starch 3%, dispersing agent naphthalene sulfonate 2%, polycarboxylate sodium 8%, defoaming agent 1%, grinding aid magnesium stearate 0.5%, disintegrating agent urea
1%, filler is that calcined kaolin complements to 100%, and pre-add water in the kettle that feeds intake (liquid and solids ratios be 1:1), material is in order
The addition kettle that feeds intake is sheared to homogeneous, is sanded through sand mill to partial size d98≤5 μm and is entered finished product kettle.Stabilizer is added in finished product kettle
Polyvinyl alcohol 1%, xanthan gum 0.15%, carboxymethyl cellulose 0.5% stir evenly.Material is transmitted to by high-pressure pump after filtering
Tower top atomization.Inlet air temperature is set as 100 DEG C, and leaving air temp is set as 72 DEG C, is dried to sky in press spray drier
The heart is coccoid, screened to obtain 80% Fluoxastrobin Tebuconazole dry suspending agent of finished product.
1 45% Fluoxastrobin Tebuconazole dry suspending agent of comparative example
Comparative example 1 is same as Example 1, in addition to being added without xanthan gum and other stabilizers.
2 45% Fluoxastrobin Tebuconazole dry suspending agent of comparative example
Comparative example 2 is same as Example 1, in addition to being added without binder straight chain corn starch.
Comparative example 3
Comparative example 3 is same as Example 1, in addition to being added without lincomycin.
Product indices
The resulting dry suspending agent of embodiment 1-8 and comparative example 1-3 is subjected to indices detection, acquired results see the table below 1.
The embodiment 1-8 indices testing result of 1 dry suspending agent of table
It will be seen from figure 1 that dry suspending agent indices made from embodiment 1-8 are qualification, wherein Fluoxastrobin and Tebuconazole
Suspensibility be all larger than 85%, resulting product is had excellent performance.
It can be seen that from comparative example 1, be added without xanthan gum and other stabilizers, sample disintegration rate is higher, slow release
It can will be verified in drug test later, but suspensibility is insufficient.From comparative example 2 as can be seen that in production technology
Under the premise of constant, it is added without amylose, the disintegration time of finished product becomes longer, and moisture content is also slightly higher.
Drug study
Application of the dry suspending agent in prevention and treatment rice sheath blight disease and false smut.
The drug study and Comparative result of part implementation embodiment and other dosage form products is set forth below to prove the present invention
The advantages of.
Respectively Example 1,3,5,7 and comparative example 1,2,3 and 70% Fluoxastrobin WDG, 75% trifloxystrobin Tebuconazole WDG,
24% thifluzamide SC is compareed.
1. trial crops and object
Examination is local rice for crop, and subjects are banded sclerotial blight and false smut
2. the process of test
Entire test process selects 20 pieces of experimental plots to be tested based on fine day, wherein 10 pieces carry out the anti-of rice sheath blight disease
Control research, the study on prevention of 10 pieces of progress rice green smuts.Every piece of experimental plot area is 333.3 ㎡, and per hectare effective component contains
Amount is 100-160g, and the prevention and treatment field experimental plot number 1-10 of rice sheath blight disease is administered in boot stage, and when herbal sprinkling presses
Every 10-30g/ mus is administered, dilution 3000 times carry out using,.7 days and 20 days preventive effects after observation medicine.Rice green smut
Prevention and treatment field number 11-20, experimental plot is administered in the cut phase, and when herbal sprinkling is administered by every 10-30g/ mus, dilution
3000 times carry out using 7 days and 20 days preventive effects after observation medicine.The same day weather of application for the first time is fine, and 23 DEG C of the highest temperature, lowest temperature
12℃；Second of application same day weather is clear to cloudy, and 27 DEG C of the highest temperature, 18 DEG C of lowest temperature.
3. experimental result
Drug see the table below 2 to the control efficiency of rice sheath blight disease.
Drug see the table below 3 to the control efficiency of rice green smut.
The field control effect of the different bactericidal agent for preventing and treating rice sheath blight diseases of table 2
2 experimental result of table
From table 2 it can be seen that the using effect of compounding dry suspending agent is significantly better than the using effect of control group single dose, it is administered 7 days
Preventive effect of the preventive effect afterwards after 90% or more, application 20 days is also 85% or more.Control group is compared, the effective component of embodiment is applied
Dose significantly reduces, and also more significant in the preventive effect after application 20 days, and drug effect is more preferable.7 days preventive effect effects of comparative example 1 are bright
It is aobvious, but the preventive effect advantage after 20 days is unobvious, it is generally related with its sustained release performance.The explanation of comparative example 3 does not add lincomycin,
Control efficiency has more apparent reduction.
The field control effect of the different bactericidal agent for preventing and treating rice green smuts of table 3
3 experimental result of table
From table 3 it can be seen that the using effect of compounding dry suspending agent is significantly better than the using effect of control group single dose, it is administered 7 days
Preventive effect of the preventive effect afterwards after 90% or more, application 20 days is also 85% or more.Comparative example and control group are compared, embodiment
Effective component formulation rate significantly reduces, and also more significant in the preventive effect after application 20 days, and drug effect is more preferable.
7 days preventive effect effects of comparative example 1 are obvious, but the preventive effect advantage after 20 days is unobvious, generally has with its sustained release performance
It closes.The explanation of comparative example 3 does not add lincomycin, and control efficiency has more apparent reduction.
The present invention provides a kind of using Fluoxastrobin and Tebuconazole as the preparation method of the slow-release dry suspending agent of effective component
And application, resulting product have good drug efficacy, the duration is long, the few advantage of formulation rate；To rice sheath blight disease and false smut
Control efficiency is also better than other kinds of fungicide.
Above-described embodiment is only the composition and process characteristic for illustrating this system, and its object is to allow those skilled in the art
The contents of the present invention can be understood and be implemented, it is not intended to limit the scope of the present invention.All reference this systems or
The technical solution that person's equivalent substitution mode is formed, should all fall within the scope of the hereto appended claims.
Claims (7)
1. a kind of slow-release dry suspending agent containing Fluoxastrobin and Tebuconazole, it is characterised in that: the dry suspending agent is hollow beads
Shape dry suspending agent has slow release effect, includes: effective component 10-90wt%, wetting agent 1-10 wt %, dispersing agent 5-25wt%,
Binder 1-5wt%, bleeding agent 1-5 wt %, disintegrating agent 1-20wt%, defoaming agent 0.1-3wt%, grinding aid 0.1-5wt% stablize
Agent 1-8wt%, filler complement to 100wt%；The effective component is Fluoxastrobin, Tebuconazole and lincomycin, the weight ratio of three
For 1-80:1-80:0.1-0.3.
2. the slow-release dry suspending agent according to claim 1 containing Fluoxastrobin and Tebuconazole, which is characterized in that described effective
The content of ingredient is 60-80wt%.
3. the slow-release dry suspending agent according to claim 1 containing Fluoxastrobin and Tebuconazole, which is characterized in that the stabilization
Agent includes: one in xanthan gum, and polyvinyl alcohol, cyclodextrin, carboxymethyl cellulose, sodium carboxymethyl starch, modification of chitosan
Kind or more than one.
4. the slow-release dry suspending agent according to claim 1 containing Fluoxastrobin and Tebuconazole, which is characterized in that dispersing agent is
Lignosulfonates or naphthalene sulfonate and polycarboxylate.
5. the slow-release dry suspending agent according to claim 1 containing Fluoxastrobin and Tebuconazole, which is characterized in that binder is
Straight chain corn starch.
6. the slow-release dry suspending agent according to claim 1-5 containing Fluoxastrobin and Tebuconazole is withered to the line of rice
Disease, the application of the prevention and treatment of false smut.
7. a kind of preparation method of the slow-release dry suspending agent containing Fluoxastrobin and Tebuconazole, which comprises the following steps:
(1) solid is pressed wetting agent by the 50% of the total component of pre-add water Zhan in kettle of feeding intake, dispersing agent, binder, defoaming agent, effective component,
Grinding aid, disintegrating agent, filler feed intake in order shearing in kettle be recycled to it is homogeneous；
(2) material sheared is sanded by sand mill to partial size d98≤5 μm, the material after sand milling, which is put into finished product kettle, to be held
Continuous stirring, is added stabilizer, continues to stir evenly；
(3) spray dryer preheating makes inlet air temperature reach 110 DEG C, and leaving air temp reaches 60 DEG C, after material is filtered,
Material is delivered to tower top with given pace by high-pressure pump, material is atomized into droplet by tower top atomizer, after drying, directly
It connects to obtain the dry suspending agent particle of internal defect, it is screened to obtain finished product dry suspending agent later.
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| CN201910587477.7A CN110278945A (en) | 2019-07-02 | 2019-07-02 | A kind of slow-release dry suspending agent and preparation method thereof containing Fluoxastrobin and Tebuconazole |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN114176088A (en) * | 2021-12-03 | 2022-03-15 | 中化化工科学技术研究总院有限公司 | Azoxystrobin dry suspending agent and preparation method thereof |
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| CN114176088A (en) * | 2021-12-03 | 2022-03-15 | 中化化工科学技术研究总院有限公司 | Azoxystrobin dry suspending agent and preparation method thereof |
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