CN110261309B - Magnetomotive optical coherence tomography system and magnetic field modulation method thereof - Google Patents
Magnetomotive optical coherence tomography system and magnetic field modulation method thereof Download PDFInfo
- Publication number
- CN110261309B CN110261309B CN201910590524.3A CN201910590524A CN110261309B CN 110261309 B CN110261309 B CN 110261309B CN 201910590524 A CN201910590524 A CN 201910590524A CN 110261309 B CN110261309 B CN 110261309B
- Authority
- CN
- China
- Prior art keywords
- sample
- fan blade
- magnetic
- magnetic field
- magnetic rod
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/41—Refractivity; Phase-affecting properties, e.g. optical path length
- G01N21/45—Refractivity; Phase-affecting properties, e.g. optical path length using interferometric methods; using Schlieren methods
Abstract
The invention discloses a magnetic-driven optical coherence tomography system and a magnetic field modulation method thereof. The system comprises an OCT device and a magnetic modulation device, wherein the OCT device comprises a control system, an optical signal receiving and transmitting module, a sample arm and a reference arm, an optical signal entering the sample arm sequentially enters the sample stage through the scanning galvanometer, the collimating and focusing lens group, a sample on the sample stage scatters light modulated by a bidirectional magnetic field and then sequentially interferes with light reflected by the sample stage, the collimating and focusing lens group and the scanning galvanometer and light reflected by the reference arm, an interference signal enters the optical signal receiving and transmitting module, and the control system performs data processing according to the interference signal to obtain a structure diagram of the sample and a phase diagram of a sample motion state. The magnetic-driven optical coherence tomography system and the magnetic field modulation method thereof provided by the invention can realize rapid modulation, reduce unnecessary energy consumption and effectively prolong the working time.
Description
Technical Field
The invention relates to the technical field of magnetic-driven optical coherence tomography systems, in particular to a magnetic-driven optical coherence tomography system and a magnetic field modulation method thereof.
Background
Optical Coherence Tomography (OCT) is a cross-sectional imaging method that can provide high resolution in clinical and research applications. A magnetic-driven optical coherence tomography (MM-OCT) system is a functional extension of OCT, and the principle is that the OCT is utilized to detect the motion condition of paramagnetic nanoparticles (MNPS) in tissues modulated by an external magnetic field so as to realize the tracing of the nanoparticles. According to MM-OCT theory, after application of an external modulating magnetic field, MM-OCT signal strength depends on the displacement and velocity of the MNPS caused by the external magnetic field. Upon MM-OCT imaging, MNPS is distributed within biological tissues and its motion is limited by the viscoelastic properties of the tissues. The effective magnetic field modulation method can accelerate MNPS movement, thereby improving the signal-to-noise ratio and the acquisition speed of the system.
The journal entitled "Dual-coil magnetic optical coherence tomography for contrast enhancement in requirements" discloses a Dual-coil modulation method, wherein two coils are coaxially arranged up and down and alternately applied with driving current, namely only one magnetic field drives MNPS to move at any moment, and a sample is arranged near the middle axis of the two coils. However, the energy consumption of the double coils caused by mutual inductance is large, and the electromagnetic coils can generate heat when in work, so that the long-time work is difficult to realize if water cooling or other cooling measures are not carried out. Compared with the prior art, the static magnetic long-time energy consumption is low, and the device is suitable for long-time work.
Disclosure of Invention
The invention provides a magnetic-driven optical coherence tomography system and a magnetic field modulation method thereof, and provides a method for modulating paramagnetic nanoparticles in tissues based on static magnetic field shielding, which can realize rapid modulation, reduce unnecessary energy consumption and effectively prolong the working time.
In order to achieve the purpose, the invention provides the following scheme:
a magnetic-driven optical coherence tomography system comprises an OCT device and a magnetic modulation device, wherein the OCT device comprises a control system, an optical signal transceiver module, a sample arm and a reference arm, the optical signal transceiver module sends two paths of optical signals, one path of optical signal enters the sample arm, the other path of optical signal enters the reference arm, the magnetic modulation device realizes bidirectional magnetic field modulation on a sample table by using a double static magnetic field alternative shielding method, the sample arm comprises a scanning galvanometer, a collimating and focusing lens group and a sample table, the magnetic modulation device comprises a fixing frame, an A magnetic rod, a B magnetic rod, an A fan blade disc, a B fan blade disc, a motor and a power supply device, the power supply device supplies voltage to the motor, the A magnetic rod is fixedly installed at the upper end of the fixing frame, the B magnetic rod which is arranged opposite to the A magnetic rod is arranged at the lower end of the fixing frame, the sample stage is also arranged on the fixed frame, the sample stage and the B magnetic field are positioned on the same side, the output shaft of the motor is provided with the A sector disc and the B sector disc, the A sector disc and the B sector disc are circumferentially positioned on the output shaft of the motor through key slots, the A sector disc is arranged between the sample stage and the A magnetic rod, the B sector disc is arranged between the sample stage and the B magnetic rod, an optical signal entering a sample arm sequentially passes through the scanning galvanometer, the collimating and focusing lens group and enters the sample stage, a sample on the sample stage is subjected to light scattering modulated by the bidirectional magnetic field and then sequentially interferes along the light reflected by the sample stage, the collimating and focusing lens group, the scanning galvanometer and the reference arm, the interference signal enters the optical signal transceiver module, and the optical signal transceiver module transmits the interference signal to the control system, and the control system performs data processing according to the interference signal to obtain a structure diagram of the sample and a phase diagram of the motion state of the sample.
Optionally, the control system is a data processor or a computer.
Optionally, the scanning galvanometer includes an X scanning galvanometer and a Y scanning galvanometer.
Optionally, the fan blade disc a and the fan blade disc B are made of iron-nickel alloy plates.
Optionally, all include 4 flabellum on A flabellum dish, the B flabellum dish, the contained angle between the adjacent flabellum is 45 on the A flabellum dish, the contained angle between the adjacent flabellum is 45 on the B flabellum dish.
A method of magnetic field modulation of a magnetomotive optical coherence tomography system, the method comprising:
step 1: the magnetic modulation device realizes the bidirectional magnetic field modulation of the sample on the sample table by using a double static magnetic field alternative shielding method;
step 2: the optical signal transceiver module sends two optical signals, wherein one optical signal enters the sample arm, and the other optical signal enters the reference arm;
and step 3: the optical signal entering the sample arm sequentially passes through the scanning galvanometer, the collimating and focusing lens group and is incident to the sample stage, the sample on the sample stage scatters the light modulated by the bidirectional magnetic field, then the light reflected by the scanning galvanometer and the light reflected by the reference arm are interfered in sequence along the sample stage, the collimating and focusing lens group and the scanning galvanometer, and the generated interference signal is transmitted to the optical signal transceiver module;
and 4, step 4: the optical signal receiving and transmitting module transmits the interference signal to the control system, and the control system performs data processing on the interference signal to obtain a structure diagram of the sample and a phase diagram reflecting the movement state of the sample.
Optionally, the step 1: the magnetic modulation device realizes the bidirectional magnetic field modulation of the sample on the sample platform by using a double static magnetic field alternative shielding method, and specifically comprises the following steps:
setting the angle difference of the blade disc A and the blade disc B on the blade layout as a;
the fan blade disc A and the fan blade disc B are circumferentially positioned on an output shaft of the motor through key slots;
the motor drives the output shaft to enable the fan blade disc A and the fan blade disc B to rotate at a set rotating speed, and only one fan blade is located between the magnetic rod A and the magnetic rod B, so that the magnetic rod A and the magnetic rod B alternately attract samples on the sample table.
Optionally, make A flabellum dish, B flabellum dish rotatory with setting for the rotational speed through motor drive output shaft, have and only have a flabellum to be located A bar magnet and B bar magnet in the middle of, realize A bar magnet, B bar magnet and to the alternate attraction of sample on the sample platform, specifically include:
the output shaft is driven by the motor to enable the fan blade disc A and the fan blade disc B to rotate at a set rotating speed, when one fan blade on the fan blade disc B shields the magnetic field of the magnetic rod B which is positioned on the same side of the sample platform as the fan blade disc B, the magnetic rod A attracts a sample on the sample platform; when the fan blade disc A is provided with a fan blade to shield the magnetic field of the fan blade disc A far away from the magnetic rod A of the sample table, the magnetic rod B attracts the sample on the sample table;
along with the rotation of the motor output shaft, the A magnetic rod, the B magnetic rod and the sample platform are alternately shielded by the fan blades, so that the A magnetic rod and the B magnetic rod alternately attract samples on the sample platform.
Optionally, the value of the angle difference a is 22.5 °.
Compared with the prior art, the technology has the following beneficial effects:
the magnetic field modulation method based on the magnetomotive optical coherence tomography system provided by the invention controls the modulation period of the magnetic field by adjusting the rotating speed of the motor, and compared with a double-coil magnetic field, the magnetic field modulation method not only can realize rapid modulation, but also has less energy consumption, does not need to be cooled and can work for a long time. The method realizes the modulation of the sample in two directions by adopting a mode of alternately shielding static magnetic fields, and the device has no electromagnetic radiation and no side effect on the body function.
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings needed to be used in the embodiments will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art to obtain other drawings without inventive exercise.
FIG. 1 is a schematic structural diagram of a magnetomotive optical coherence tomography system according to an embodiment of the present invention;
FIG. 2 is a top view of a blisk according to an embodiment of the present invention;
FIG. 3 is a schematic structural diagram of an OCT apparatus according to an embodiment of the invention;
FIG. 4 is a block diagram of a sample;
fig. 5 is a phase diagram reflecting the movement of the sample.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The invention provides a magnetic field modulation method based on a magnetic-driven optical coherence tomography system, and provides a method for modulating paramagnetic nanoparticles in tissues based on static magnetic field shielding, which can realize rapid modulation, reduce unnecessary energy consumption and effectively prolong the working time.
In order to make the aforementioned objects, features and advantages of the present invention comprehensible, embodiments accompanied with figures are described in further detail below.
FIG. 1 is a schematic structural diagram of a DC ground electrical branch testing system with variable ground resistance controlled by a routine, as shown in FIG. 1, a magnetic-driven optical coherence tomography system includes an OCT device and a magnetic modulation device, the OCT device includes an optical signal receiving and reference arm module 1 and a sample arm, the optical signal receiving and reference arm module 1 is disposed on a fixed frame 12, the optical signal receiving and reference arm module 1 includes a control system 15, an optical signal transceiver module 14 and a reference arm 13, the optical signal transceiver module 14 transmits two optical signals, one optical signal enters the sample arm, the other optical signal enters the reference arm 13, the magnetic modulation device utilizes a method of double static magnetic field alternate shielding to realize bidirectional magnetic field modulation on a sample stage 4, the sample arm includes a scanning galvanometer 2, a collimating and focusing lens group 3, The sample stage 4, the magnetism adjusting device includes a fixing frame 12, an A magnetic rod 5, a B magnetic rod 6, an A fan blade disc 7, a B fan blade disc 8, a motor 10 and a power supply device 11, the power supply device 11 provides voltage for the motor 10, the upper end of the fixing frame 12 is fixedly provided with the A magnetic rod 5, the lower end of the fixing frame 12 is provided with the B magnetic rod 6 which is arranged opposite to the A magnetic rod 5, the fixing frame is also provided with the sample stage, the sample stage and the B magnetic field are positioned on the same side, the output shaft 9 of the motor 10 is provided with the A fan blade disc 7 and the B fan blade disc 8, the A fan blade disc 7 and the B fan blade disc 8 are circumferentially positioned on the output shaft 9 of the motor 10 through key slots, the A fan blade disc 7 is arranged between the sample stage 4 and the A magnetic rod 5, the B fan blade disc 8 is arranged between the sample stage 4 and the B magnetic rod 6, an optical signal entering a sample arm sequentially passes through the scanning galvanometer 2 and the collimating and focusing lens group 3 to be incident to the sample stage 4, a sample on the sample stage 4 scatters light modulated by a bidirectional magnetic field and then interferes with light reflected by the sample stage 4, the collimating and focusing lens group 3 and the scanning galvanometer 2 and light reflected by the reference arm 13, the interference signal enters the optical signal transceiver module 14, the optical signal transceiver module 14 transmits the interference signal to the control system 15, and the control system 15 performs data processing according to the interference signal to obtain a structure diagram of the sample and a phase diagram of the motion state of the sample.
The control system 15 is a data processor or a computer. The scanning galvanometer 2 comprises an X scanning galvanometer and a Y scanning galvanometer.
A method of magnetic field modulation of a magnetomotive optical coherence tomography system, the method comprising:
step 1: the magnetic modulation device realizes the bidirectional magnetic field modulation of the sample on the sample stage 4 by using a double static magnetic field alternative shielding method;
step 2: the optical signal transceiver module 14 sends two optical signals, wherein one optical signal enters the sample arm, and the other optical signal enters the reference arm 13;
and step 3: the optical signal entering the sample arm sequentially passes through the scanning galvanometer 2 and the collimating and focusing lens group 3 to be incident to the sample stage 4, the sample on the sample stage 4 scatters the light modulated by the bidirectional magnetic field and then interferes with the light reflected by the scanning galvanometer 2 and the reference arm 13 sequentially along the sample stage 4, the collimating and focusing lens group 3 and the scanning galvanometer 2, and the generated interference signal is transmitted to the optical signal transceiver module 14;
and 4, step 4: the optical signal transceiver module 14 transmits the interference signal to the control system 15, and the control system 15 performs data processing on the interference signal to obtain a structure diagram of the sample and a phase diagram reflecting the motion state of the sample.
The step 1: the magnetic modulation device realizes the bidirectional magnetic field modulation of the sample on the sample platform by using a double static magnetic field alternative shielding method, and specifically comprises the following steps:
setting the angle difference of the blade disc 7A and the blade disc 8B on the blade layout as a; the value of the angular difference a is 45 °.
The fan blade disc A7 and the fan blade disc B8 are circumferentially positioned on an output shaft 9 of a motor 10 through key slots;
the motor 10 drives the output shaft 9 to enable the fan blade disc A7 and the fan blade disc B8 to rotate at a set rotating speed, and only one fan blade is located between the magnetic rod A5 and the magnetic rod B6, so that the magnetic rod A5 and the magnetic rod B6 can alternatively attract samples on the sample table 4.
the output shaft 9 is driven by the motor 10 to enable the fan blade disc A7 and the fan blade disc B8 to rotate at a set rotating speed, when one fan blade on the fan blade disc B8 shields the magnetic field of the magnetic rod B6 which is positioned on the same side of the sample table 4 with the fan blade, the magnetic rod A5 attracts a sample on the sample table 4; when a fan blade on the fan blade disc A7 shields the magnetic field of the magnetic rod A5 far away from the sample table 4, the magnetic rod B6 attracts the sample on the sample table 4;
along with the rotation of the output shaft 9 of the motor 10, the A magnetic rod 5, the B magnetic rod 6 and the sample table 4 are alternately shielded by the fan blades, so that the A magnetic rod 5 and the B magnetic rod 6 can alternately attract samples on the sample table 4.
A method for realizing bidirectional modulation by using double static magnetic field to shield alternatively. The static magnetic field is provided by two static magnetic rods, the N pole (or S pole) top heads of the two magnetic rods are fixed, the static magnetic fields in two fixed directions of the sample are alternately shielded by the iron-nickel alloy plates at intervals, and the alternating attraction of the static magnetic field to the sample is realized.
The magnetic modulation device comprises a fixed frame 12, an A magnetic rod 5, a B magnetic rod 6, an A fan blade disc 7 and a B fan blade disc 8 which are made of iron-nickel alloy plates, an output shaft 9 of a motor 10, the motor 10 and a power supply device 11. The power supply device 11 is connected with the motor 10, an output shaft 9 is arranged on the motor 10, and the fan blade disc A7 and the fan blade disc B8 are fixed on the output shaft 9. The blade disk A7 and the blade disk B8 realize circumferential positioning on the output shaft 9 through key slots. The blade arrangement of the blade disc A7 and the blade disc B8 has an angle difference a. The output shaft 9 drives the fan blade disc A7 and the fan blade disc B8 to rotate in the same rotating speed and the same direction, the angle difference a ensures that at any moment, only one fan blade of the fan blade disc A7 and the fan blade disc B8 is located between the magnetic rod A5 and the magnetic rod B6, the magnetic rod A5, the magnetic rod B6 and the sample platform 4 use a fixing frame 12, and the magnetic rod A5 and the magnetic rod B6 are respectively fixed on two sides of the sample platform 4 of the system. The device controls the magnetic field intensity by adjusting the distances between the fan blade disk A7 and the fan blade disk B8 and between the magnetic rod A5 and the magnetic rod B6 and the sample table 4, and sets the modulation frequency by changing the number of the fan blades of the fan blade disk A7 and the fan blade disk B8 and the rotating speed of the output shaft 9.
The magnetic modulation system drives the output shaft 9 by using the motor 10 to enable the fan blade disc A7 and the fan blade disc B8 to rotate at a certain rotating speed, at a certain moment, one fan blade of the fan blade disc B8 shields the magnetic field of the magnetic rod B6 which is positioned at the same side of the sample platform 4 with the fan blade, and at the moment, no fan blade is shielded between the other magnetic rod A5 and the sample platform 4, namely, the magnetic rod A5 attracts a sample. The position of the fan blade is changed along with the rotation of the rotating shaft 9, and when the fan blade of the B fan blade disc 8 rotates away from the position right above the B magnetic rod 6, the fan blade of the A fan blade disc 7 at the moment shields the magnetic field of the A magnetic rod 5. Therefore, the two magnetic rods and the sample are alternately shielded by the fan blade disc (alternate electromagnetic shielding), and the alternate attraction of the magnetic rods to the sample on the sample table is realized.
Fig. 2 is a top view of a flabellum a and a flabellum B according to an embodiment of the present invention, and as shown in fig. 2, the flabellum a 7 and the flabellum B8 are made of an iron-nickel alloy plate. All include 4 flabellums on A flabellum dish 7, the B flabellum dish 8, the contained angle between the adjacent flabellum is 45 on the A flabellum dish 7, the contained angle between the adjacent flabellum is 45 on the B flabellum dish 8. The fan blade disc A7 and the fan blade disc B8 are circumferentially positioned on the output shaft 9 through key slots. The blade arrangement of the blade disc A7 and the blade disc B8 has an angle difference a. The value of the angular difference a is 22.5 °.
Fig. 3 is a schematic structural diagram of an OCT apparatus according to an embodiment of the present invention, and as shown in fig. 3, the OCT apparatus includes an optical signal receiving and reference arm module 1, a scanning galvanometer 2, a collimating and focusing lens group 3, and a sample stage 4. The sample light beam enters a sample stage 4 through a scanning galvanometer 2 and a collimating and focusing lens group 3, is scattered by the sample, returns along the sample stage 4, the collimating and focusing lens group 3 and the scanning galvanometer 2 and interferes with the reference arm 13. The interference spectrum enters the optical signal transceiver module 14 and the control system 15, and a structure diagram 4 and a phase diagram 5 reflecting the movement state of the sample are obtained after data processing, as shown in fig. 4 and 5.
The magnetic field modulation method based on the magnetomotive optical coherence tomography system provided by the invention controls the modulation period of the magnetic field by adjusting the rotating speed of the motor, and compared with a double-coil magnetic field, the magnetic field modulation method not only can realize rapid modulation, but also has less energy consumption, does not need to be cooled and can work for a long time. The method realizes the modulation of the sample in two directions by adopting a mode of alternately shielding static magnetic fields, and the device has no electromagnetic radiation and no side effect on the body function. The invention provides a magnetic field modulation method based on a magnetic-driven optical coherence tomography system, and provides a method for modulating paramagnetic nanoparticles in tissues based on static magnetic field shielding, which can realize rapid modulation, reduce unnecessary energy consumption and effectively prolong the working time.
The embodiments in the present description are described in a progressive manner, each embodiment focuses on differences from other embodiments, and the same and similar parts among the embodiments are referred to each other.
The principles and embodiments of the present invention have been described herein using specific examples, which are provided only to help understand the method and the core concept of the present invention; meanwhile, for a person skilled in the art, according to the idea of the present invention, the specific embodiments and the application range may be changed. In view of the above, the present disclosure should not be construed as limiting the invention.
Claims (9)
1. A magnetic-driven optical coherence tomography system is characterized by comprising an OCT device and a magnetic modulation device, wherein the OCT device comprises a control system, an optical signal transceiver module, a sample arm and a reference arm, the optical signal transceiver module sends two paths of optical signals, one path of optical signal enters the sample arm, the other path of optical signal enters the reference arm, the magnetic modulation device realizes bidirectional magnetic field modulation on a sample table by using a double static magnetic field alternative shielding method, the sample arm comprises a scanning galvanometer, a collimating and focusing lens group and a sample table, the magnetic modulation device comprises a fixing frame, an A magnetic rod, a B magnetic rod, an A fan blade disc, a B fan blade disc, a motor and a power supply device, the power supply device supplies voltage to the motor, the A magnetic rod is fixedly installed at the upper end of the fixing frame, the B magnetic rod which is arranged opposite to the A magnetic rod is arranged at the lower end of the fixing frame, the sample stage is also arranged on the fixed frame, the sample stage and the B magnetic field are positioned on the same side, the output shaft of the motor is provided with the A sector disc and the B sector disc, the A sector disc and the B sector disc are circumferentially positioned on the output shaft of the motor through key slots, the A sector disc is arranged between the sample stage and the A magnetic rod, the B sector disc is arranged between the sample stage and the B magnetic rod, an optical signal entering a sample arm sequentially passes through the scanning galvanometer, the collimating and focusing lens group and enters the sample stage, a sample on the sample stage is subjected to light scattering modulated by the bidirectional magnetic field and then sequentially interferes along the light reflected by the sample stage, the collimating and focusing lens group, the scanning galvanometer and the reference arm, the interference signal enters the optical signal transceiver module, and the optical signal transceiver module transmits the interference signal to the control system, and the control system performs data processing according to the interference signal to obtain a structure diagram of the sample and a phase diagram of the motion state of the sample.
2. Magnetomotive optical coherence tomography system according to claim 1, wherein said control system is a data processor.
3. Magnetomotive optical coherence tomography system according to claim 1, wherein said scanning galvanometer comprises an X-scanning galvanometer and a Y-scanning galvanometer.
4. Magnetomotive optical coherence tomography system according to claim 1, wherein the fan blade discs a and B are made of iron-nickel alloy plates.
5. The magnetomotive optical coherence tomography system of claim 1, wherein the fan blade disk A and the fan blade disk B each comprise 4 fan blades, the included angle between adjacent fan blades on the fan blade disk A is 45 °, and the included angle between adjacent fan blades on the fan blade disk B is 45 °.
6. A magnetic field modulation method based on the magnetomotive optical coherence tomography system of claim 1, the method comprising:
step 1: the magnetic modulation device realizes the bidirectional magnetic field modulation of the sample on the sample table by using a double static magnetic field alternative shielding method;
step 2: the optical signal transceiver module sends two optical signals, wherein one optical signal enters the sample arm, and the other optical signal enters the reference arm;
and step 3: the optical signal entering the sample arm sequentially enters the sample stage through the scanning galvanometer, the collimating and focusing lens group, the sample on the sample stage scatters the light modulated by the bidirectional magnetic field, then the light reflected by the scanning galvanometer and the light reflected by the reference arm are sequentially interfered along the sample stage, the collimating and focusing lens group and the scanning galvanometer, and the generated interference signal is transmitted to the optical signal receiving and transmitting module;
and 4, step 4: the optical signal receiving and transmitting module transmits the interference signal to the control system, and the control system performs data processing on the interference signal to obtain a structure diagram of the sample and a phase diagram reflecting the movement state of the sample.
7. The magnetic field modulation method of a magnetomotive optical coherence tomography system according to claim 6, wherein the step 1: the magnetic modulation device realizes the bidirectional magnetic field modulation of the sample on the sample platform by using a double static magnetic field alternative shielding method, and specifically comprises the following steps:
setting the angle difference of the blade disc A and the blade disc B on the blade layout as a;
the fan blade disc A and the fan blade disc B are circumferentially positioned on an output shaft of the motor through key slots;
the motor drives the output shaft to enable the fan blade disc A and the fan blade disc B to rotate at a set rotating speed, and only one fan blade is located between the magnetic rod A and the magnetic rod B, so that the magnetic rod A and the magnetic rod B alternately attract samples on the sample table.
8. The magnetic field modulation method of the magnetomotive optical coherence tomography system according to claim 7, wherein the motor drives the output shaft to rotate the fan blade disk A and the fan blade disk B at a set rotation speed, and only one fan blade is located between the magnetic rod A and the magnetic rod B, so as to realize the alternate attraction of the magnetic rod A and the magnetic rod B to the sample on the sample stage, specifically comprising:
the output shaft is driven by the motor to enable the fan blade disc A and the fan blade disc B to rotate at a set rotating speed, when one fan blade on the fan blade disc B shields the magnetic field of the magnetic rod B which is positioned on the same side of the sample platform as the fan blade disc B, the magnetic rod A attracts a sample on the sample platform; when the fan blade disc A is provided with a fan blade to shield the magnetic field of the fan blade disc A far away from the magnetic rod A of the sample table, the magnetic rod B attracts the sample on the sample table;
along with the rotation of the motor output shaft, the A magnetic rod, the B magnetic rod and the sample platform are alternately shielded by the fan blades, so that the A magnetic rod and the B magnetic rod alternately attract samples on the sample platform.
9. The method for modulating the magnetic field of a magnetomotive optical coherence tomography system according to claim 7, wherein the angular difference a is 22.5 °.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910590524.3A CN110261309B (en) | 2019-07-02 | 2019-07-02 | Magnetomotive optical coherence tomography system and magnetic field modulation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910590524.3A CN110261309B (en) | 2019-07-02 | 2019-07-02 | Magnetomotive optical coherence tomography system and magnetic field modulation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN110261309A CN110261309A (en) | 2019-09-20 |
| CN110261309B true CN110261309B (en) | 2021-09-28 |
Family
ID=67923896
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910590524.3A Active CN110261309B (en) | 2019-07-02 | 2019-07-02 | Magnetomotive optical coherence tomography system and magnetic field modulation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110261309B (en) |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1251345A1 (en) * | 2001-04-12 | 2002-10-23 | Fuji Photo Film Co., Ltd. | Measuring sensor utilizing attenuated total reflection and measuring chip assembly |
| CN201016933Y (en) * | 2007-03-09 | 2008-02-06 | 三明学院 | Signal detecting element of magnetomotive oxygen content measuring instrument |
| CN101552533A (en) * | 2008-02-27 | 2009-10-07 | 陈晓华 | Wind power generator without fan blades |
| CN202010143U (en) * | 2011-03-15 | 2011-10-19 | 深圳市斯尔顿科技有限公司 | Light barring rotating disc used for frequency domain OCT system and frequency domain OCT system |
| CN105246414A (en) * | 2013-05-06 | 2016-01-13 | Nkij工程公司 | Magnetomotive probe system and method of use thereof |
| CN106872408A (en) * | 2017-04-26 | 2017-06-20 | 赣南师范大学 | A kind of planktonic organism imaging detection device |
| CN109297595A (en) * | 2018-09-04 | 2019-02-01 | 东北大学秦皇岛分校 | A kind of optical coherence tomography phase unwrapping around method and device |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8036732B2 (en) * | 2006-10-18 | 2011-10-11 | Board Of Regents, The University Of Texas System | Hemoglobin contrast in magneto-motive optical doppler tomography, optical coherence tomography, and ultrasound imaging methods and apparatus |
| US7751057B2 (en) * | 2008-01-18 | 2010-07-06 | The Board Of Trustees Of The University Of Illinois | Magnetomotive optical coherence tomography |
-
2019
- 2019-07-02 CN CN201910590524.3A patent/CN110261309B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1251345A1 (en) * | 2001-04-12 | 2002-10-23 | Fuji Photo Film Co., Ltd. | Measuring sensor utilizing attenuated total reflection and measuring chip assembly |
| CN201016933Y (en) * | 2007-03-09 | 2008-02-06 | 三明学院 | Signal detecting element of magnetomotive oxygen content measuring instrument |
| CN101552533A (en) * | 2008-02-27 | 2009-10-07 | 陈晓华 | Wind power generator without fan blades |
| CN202010143U (en) * | 2011-03-15 | 2011-10-19 | 深圳市斯尔顿科技有限公司 | Light barring rotating disc used for frequency domain OCT system and frequency domain OCT system |
| CN105246414A (en) * | 2013-05-06 | 2016-01-13 | Nkij工程公司 | Magnetomotive probe system and method of use thereof |
| CN106872408A (en) * | 2017-04-26 | 2017-06-20 | 赣南师范大学 | A kind of planktonic organism imaging detection device |
| CN109297595A (en) * | 2018-09-04 | 2019-02-01 | 东北大学秦皇岛分校 | A kind of optical coherence tomography phase unwrapping around method and device |
Non-Patent Citations (3)
| Title |
|---|
| "Dual-coil magnetomotive optical coherence tomography for contrast enhancement in liquids";Adeel Ahmad et al;《OPTICS EXPRESS》;20130325;第21卷(第6期);第1-9页 * |
| Magnetic and Contrast Properties of Labeled Platelets for Magnetomotive Optical Coherence Tomography;Amy L. Oldenburg et al;《Biophysical Journal》;20101030;第2374–2383页 * |
| 光学系统对磁动式测氧仪稳定性影响的研究;黄思俞 等;《光学技术》;20180331;第44卷(第2期);第206-210页 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN110261309A (en) | 2019-09-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP7097357B2 (en) | Magnetic particle imaging with a rotating magnet | |
| CN104520750B (en) | Twin axle scanning mirror | |
| CN105842638B (en) | MPI scanner with mobile permanent magnet component | |
| CN110261309B (en) | Magnetomotive optical coherence tomography system and magnetic field modulation method thereof | |
| CN105403722A (en) | Motor rotating speed measurement device | |
| CN209043460U (en) | A kind of Fourier transformation Hyperspectral imaging devices based on high speed bireflectance tilting mirror | |
| Yamamoto et al. | Evaluation of MR-compatibility of electrostatic linear motor | |
| KR102320812B1 (en) | Magnetomotive probe system and method of use thereof | |
| CN202010143U (en) | Light barring rotating disc used for frequency domain OCT system and frequency domain OCT system | |
| CN112556676B (en) | Device for adjusting motion parameters of atomic fountain | |
| CN206876956U (en) | Laser dazzling device based on minute surface vibration reflection | |
| CN207148048U (en) | The device of Fast synchronization scanning is realized based on slider-crank mechanism | |
| CN210775998U (en) | Terahertz time-domain spectrometer retroreflector driving device | |
| Guo et al. | Low voltage optical fiber positioner robot based on minimum inductance hollow cup motors | |
| CN208611614U (en) | A kind of ultrasonic probe control device in MRI-pHIFU thermal therapy system | |
| CN203241616U (en) | Hand-held confocal optical endoscope | |
| CN103257443A (en) | Handheld confocal optical endoscope | |
| CN111903206B (en) | Method for testing performance of servo control system of seeker | |
| CN108736299A (en) | A kind of two-way position regulators of frequency-doubling crystal X-Y | |
| CN203286225U (en) | Two-degree-of-freedom series type scanning platform | |
| CN217007842U (en) | Optical system and three-dimensional imaging system | |
| EP4187198A1 (en) | Distance measuring device, distance measuring method, and distance measuring program | |
| CN209727959U (en) | A kind of fluorescence detection device and fluorescence immune chromatography analyzer | |
| CN105581773B (en) | A kind of terahertz imaging system | |
| Zheng et al. | Magnetic field analysis of hybrid driven permanent magnet multi-DOF motor |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |