CN110250510A - A kind of collagen peptide complexes and preparation method thereof - Google Patents
A kind of collagen peptide complexes and preparation method thereof Download PDFInfo
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- CN110250510A CN110250510A CN201910596536.7A CN201910596536A CN110250510A CN 110250510 A CN110250510 A CN 110250510A CN 201910596536 A CN201910596536 A CN 201910596536A CN 110250510 A CN110250510 A CN 110250510A
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- collagen peptide
- anthocyanin
- chicken embryo
- inner core
- collagen
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- 102000008186 Collagen Human genes 0.000 title claims abstract description 169
- 108010035532 Collagen Proteins 0.000 title claims abstract description 169
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- 108090000765 processed proteins & peptides Proteins 0.000 title claims abstract description 169
- 238000002360 preparation method Methods 0.000 title claims abstract description 22
- 239000004410 anthocyanin Substances 0.000 claims abstract description 105
- 235000010208 anthocyanin Nutrition 0.000 claims abstract description 105
- 229930002877 anthocyanin Natural products 0.000 claims abstract description 105
- 150000004636 anthocyanins Chemical group 0.000 claims abstract description 105
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- 238000001035 drying Methods 0.000 claims description 10
- 238000001914 filtration Methods 0.000 claims description 10
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- FJHBOVDFOQMZRV-XQIHNALSSA-N xanthophyll Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C=C(C)C(O)CC2(C)C FJHBOVDFOQMZRV-XQIHNALSSA-N 0.000 description 2
- QCVGEOXPDFCNHA-UHFFFAOYSA-N 5,5-dimethyl-2,4-dioxo-1,3-oxazolidine-3-carboxamide Chemical compound CC1(C)OC(=O)N(C(N)=O)C1=O QCVGEOXPDFCNHA-UHFFFAOYSA-N 0.000 description 1
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- 229930014669 anthocyanidin Natural products 0.000 description 1
- 150000001453 anthocyanidins Chemical class 0.000 description 1
- 235000008758 anthocyanidins Nutrition 0.000 description 1
- 230000002929 anti-fatigue Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
- A23L3/40—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by drying or kilning; Subsequent reconstitution
- A23L3/46—Spray-drying
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/18—Peptides; Protein hydrolysates
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/30—Encapsulation of particles, e.g. foodstuff additives
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P20/00—Coating of foodstuffs; Coatings therefor; Making laminated, multi-layered, stuffed or hollow foodstuffs
- A23P20/10—Coating with edible coatings, e.g. with oils or fats
- A23P20/15—Apparatus or processes for coating with liquid or semi-liquid products
- A23P20/18—Apparatus or processes for coating with liquid or semi-liquid products by spray-coating, fluidised-bed coating or coating by casting
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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Abstract
The invention belongs to field of biotechnology, more particularly to a kind of collagen peptide complexes and preparation method thereof, the collagen peptide complexes, including inner core and the shell for being wrapped in inner core outer layer, the main component of the inner core is anthocyanin and collagen peptide, and the main component of the shell is collagen peptide.The present invention utilizes the stability and easy absorbability of collagen peptide; anthocyanin is protected using collagen peptide as shell; both collagen peptide and anthocyanin multiple health care may be implemented; the stability of anthocyanin can be greatly improved again; the degradation of anthocyanin, promotes human body that anthocyanin is absorbed and utilized under the conditions of reduction illumination, oxygen etc..
Description
Technical field
The invention belongs to field of biotechnology more particularly to a kind of collagen peptide complexes and preparation method thereof.
Background technique
Collagen peptide is a kind of extracellular protein, and molecular weight is mostly 0.5kDa-20kDa or so, with collagen phase
Than collagen polypeptide not only has the nutritive peculiarity of collagen, but also can be by human body active and accessible absorption, without disappearing
Change, made full use of for bodily tissue, there is the advantages that absorption easy to digest, hypoallergenic, edible safety.In addition, collagen
Polypeptide also has anti-oxidant, blood pressure lowering, improves immunity, improves memory and the bioactivity such as antitumor.Currently, depositing on the market
In miscellaneous collagen peptide health-care products, however due to formula in component it is single, it is difficult to realize multi-component health-care effect, nothing
Method meets the needs of people.
Anthocyanin is a kind of compound that anthocyanidin and sugar are combined into glycosidic bond, is widely present in flower, the fruit of plant
Reality, stem, leaf and root organ cell liquid in, research has shown that anthocyanin has and removes interior free yl, proliferation lutein, anti-swollen
Tumor, anticancer, anti-inflammatory, anti-lipid peroxidation and platelet aggregation, prevention diabetes, weight-reducing, protection eyesight and other effects.However,
Since containing a large amount of extremely unstable phenolic hydroxyl groups, the stability of anthocyanin is unsatisfactory, stability be easy by preparation processing,
The influence of some physical and chemical factors in storage, such as pH, temperature, light, oxygen, enzyme, ascorbic acid, sugar, therefore limit significantly
Application of the anthocyanin in field of health care products.
Although the prior art is no lack of the research of collagen peptide health-care products and anthocyanin health-care products, by the two
Performance and effect are combined, using the stability and easy absorbability of collagen peptide, using collagen peptide as shell to flower
Color glycosides is protected, and collagen peptide and anthocyanin multiple health care not only may be implemented, but also can greatly improve anthocyanin
Stability reduces the degradation of anthocyanin under the conditions of illumination, oxygen etc., promotes human body that anthocyanin is absorbed and utilized.
Summary of the invention
To overcome the above technical problem, the present invention provides a kind of collagen peptide complexes, utilize collagen peptide
Stability and easy absorbability protect anthocyanin using collagen peptide as shell, both may be implemented collagen peptide and
Anthocyanin multiple health care, and the stability of anthocyanin can be greatly improved, anthocyanin under the conditions of reduction illumination, oxygen etc.
Degradation promotes human body that anthocyanin is absorbed and utilized.
To achieve the above object, the present invention adopts the following technical scheme:
A kind of collagen peptide complexes, including inner core and the shell for being wrapped in inner core outer layer, the inner core it is main at
It is divided into anthocyanin and collagen peptide, the main component of the shell is collagen peptide.Utilize the stability of collagen peptide
With easy absorbability, anthocyanin is protected using collagen peptide as shell, collagen peptide and anthocyanin both may be implemented
Multiple health care, and the stability of anthocyanin can be greatly improved, the degradation of anthocyanin under the conditions of illumination, oxygen etc. is reduced,
Promote human body that anthocyanin is absorbed and utilized.
As preferential, the collagen peptide includes bone collagen peptide, Isin glue collagen peptide, chicken embryo tire collagen peptide
One of or a variety of combinations.Multiple elements design micromolecular collagen peptide has stronger reparation connective tissue, improves body
Immunity repairs brain cell, purification blood, the effect for repairing liver damage cell.
As preferential, the chicken embryo tire collagen peptide is prepared by following methods:
(1) it extracts: the decladding of chicken embryo tire, drying, crushing;Pure and mild protease is added in the chicken embryo tire of crushing and carries out diacolation, surpasses
1-3h is swung in acoustic shock, is then centrifuged for collecting upper layer percolate, and percolate recycling alcohol liquid is simultaneously concentrated, and it is spare to obtain chicken embryo extract;
(2) it digests: hydrolase is added in the chicken embryo extract obtained in step 1, is stirred under conditions of 40~60 DEG C
3~6h of enzymatic hydrolysis is mixed, then enzyme deactivation, filtering, collection filtrate, adds white bole and active carbon to stand in the filtrate of collection, filter, collect
Filtrate is spare;
(3) refine: the filtrate that step 2 is collected uses membrane filter system, separates through multistage screening, remaining concentrated phase is through going out
After bacterium, concentration, drying, chicken embryo tire collagen peptide is obtained.
Innovative utilization chicken embryo tire prepares collagen peptide, and chicken embryo tire is the animal embryo not hatched before chicken, chicken
Embryo has nutriment very rich, protein rich in, 18 kinds of amino acid, various trace elements.It utilizes
Chicken embryo tire prepares collagen peptide, can not only make full use of the collagen in chicken embryo tire, but also can retain to greatest extent therein
Different kind organism active material, and all kinds of nutriments therein are also effectively extracted, and bioavilability is high, tired with resisting
Labor, the effect of improving immunity, filling blood.In the preparation process of chicken embryo tire collagen peptide, with white bole and active carbon pair
Filtrate is cleaned, eliminated the unusual smell, it can be achieved that the beneficial effect that free from extraneous odour, mouthfeel are good.
As preferential, in the step 1, the additional amount of protease is 1~the 4 ‰ of chicken embryo tire weight;In the step 2,
The additional amount of hydrolase is 1~the 4 ‰ of chicken embryo tire weight.
As preferential, the shell includes the raw material of following parts by weight: 40~60 parts of chicken embryo tire collagen peptide, ossein
10~15 parts of protein peptides, 10~15 parts of Isin glue collagen peptide.
As preferential, the weight ratio of the inner core and shell is 0.3~0.6:1.
As preferential, the weight ratio of anthocyanin and collagen peptide is 0.2~0.4:1 in the inner core.
As preferential, the anthocyanin include one of grape pericarp anthocyanin, rose anthocyanin, roselle anthocyanin or
A variety of combinations.
The invention also discloses a kind of preparation method of collagen peptide complexes, specific technical solution is as follows:
A kind of preparation method of collagen peptide complexes, which comprises the following steps:
(1) it prepares inner core: weighing the anthocyanin freeze-dried powder and collagen peptide powder that weight ratio is 0.2~0.4:1 respectively
It is spare, anthocyanin and collagen peptide are separately added into deionized water and are uniformly mixed, anthocyanin solution and collagen are respectively obtained
Anthocyanin solution is slowly added into collagen peptide solution is uniformly mixed under stirring conditions by protein peptides solution for standby, dense
Contracting freeze-drying is granulated, is dry, obtains collagen peptide cladding anthocyanin inner core particle, spare;
(2) it coats shell: collagen peptide being added in deionized water and is uniformly mixed, collagen peptide solution is obtained, adopts
With spray drying normal direction step 1 gained inner core particle surface one layer of collagen peptide shell of spray attachment, the glue is obtained after dry
Former albumen peptide complexes.
The embedding rate of the preparation method of the collagen peptide complexes, simple process, and anthocyanin is high.Firstly,
It in the preparation process of inner core, is mixed first with anthocyanin and collagen peptide solution, realizes collagen peptide to anthocyanin
Preliminary cladding;Then, it recycles spray drying process to one layer of collagen peptide shell of inner core particle surface spray attachment, further ensures that
The embedding of anthocyanin.
Beneficial effect
(1) present invention utilizes the stability and easy absorbability of collagen peptide, using collagen peptide as shell to pattern
Glycosides is protected, and collagen peptide and anthocyanin multiple health care not only may be implemented, but also can greatly improve the steady of anthocyanin
It is qualitative, the degradation of anthocyanin under the conditions of illumination, oxygen etc. is reduced, promotes human body that anthocyanin is absorbed and utilized.
(2) collagen peptide complexes of the present invention, main component are collagen peptide and anthocyanin, collagen
Polypeptide has antioxidant activity, can eliminate free radical, reduces the pain of the Human Osteoarthritis such as knee joint or hip joint, enhances bone
Density maintains bone metabolism balance, but also has blood pressure lowering, improve immunity, improve memory and antitumor and other effects.Pattern
Glycosides have remove interior free yl, proliferation lutein, antitumor, anticancer, anti-inflammatory, anti-lipid peroxidation and platelet aggregation,
Prevent diabetes, weight-reducing, protection eyesight and other effects.Collagen peptide complexes of the present invention, have both collagen peptide and
The multiple health care of anthocyanin is a kind of easily absorption, high nutrition, nutritive health products having no toxic side effect.
(3) the innovative utilization chicken embryo tire of the present invention prepares collagen peptide, and chicken embryo tire is dynamic before not hatching chicken
Object embryo, chicken embryo mould have a nutriment very rich, protein rich in, 18 kinds of amino acid, lot of trace
Element.Collagen peptide is prepared using chicken embryo tire, can not only make full use of the collagen in chicken embryo tire, but also can protect to greatest extent
Different kind organism active material therein is stayed, and all kinds of nutriments therein are also effectively extracted, bioavilability is high, tool
There is the effect of antifatigue, to improve immunity, fill blood.In the preparation process of chicken embryo tire collagen peptide, with white bole and work
Property charcoal is cleaned, eliminated the unusual smell to filtrate, it can be achieved that the good beneficial effect of free from extraneous odour, mouthfeel.
(4) preparation method of collagen peptide complexes of the present invention, simple process, and the embedding rate of anthocyanin
It is high.Firstly, mixing in the preparation process of inner core first with anthocyanin and collagen peptide solution, collagen peptide pair is realized
The preliminary cladding of anthocyanin;Then, recycle spray drying process to one layer of collagen peptide shell of inner core particle surface spray attachment, into
One step ensures the embedding of anthocyanin.
Specific embodiment
Below in conjunction with the specific embodiment of the invention, technical solution of the present invention is clearly and completely described, is shown
So, described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.Based on the reality in the present invention
Example is applied, every other embodiment obtained by those of ordinary skill in the art without making creative efforts all belongs to
In the scope of protection of the invention.
Embodiment 1
A kind of collagen peptide complexes, including inner core and the shell for being wrapped in inner core outer layer, the inner core it is main at
It is divided into anthocyanin and collagen peptide, the main component of the shell is collagen peptide.The shell includes following parts by weight
Raw material: 40 parts of chicken embryo tire collagen peptide, 10 parts of bone collagen peptide, 15 parts of Isin glue collagen peptide.Multiple elements design small molecule
Collagen peptide has stronger reparation connective tissue, improves immunity of organisms, repair brain cell, purification blood, repair liver
The effect of damaged cell.
The weight ratio of the inner core and shell is 0.3:1.The weight ratio of anthocyanin and collagen peptide is in the inner core
0.2:1.The anthocyanin includes grape pericarp anthocyanin and rose anthocyanin, weight ratio 1:1.
Using the stability and easy absorbability of collagen peptide, anthocyanin is protected using collagen peptide as shell
Shield, not only may be implemented collagen peptide and anthocyanin multiple health care, but also can greatly improve the stability of anthocyanin, reduce
The degradation of anthocyanin under the conditions of illumination, oxygen etc. promotes human body that anthocyanin is absorbed and utilized.
The preparation method of above-mentioned collagen peptide complexes, comprising the following steps:
(1) prepare inner core: weigh respectively weight ratio be 0.2:1 anthocyanin freeze-dried powder and collagen peptide powder it is spare,
Anthocyanin and collagen peptide are separately added into deionized water and are uniformly mixed, anthocyanin solution and collagen peptide are respectively obtained
Anthocyanin solution is slowly added into collagen peptide solution is uniformly mixed under stirring conditions by solution for standby, concentrated freeze-dried,
It is granulated, is dry, obtaining collagen peptide cladding anthocyanin inner core particle, it is spare;
(2) it coats shell: collagen peptide being added in deionized water and is uniformly mixed, collagen peptide solution is obtained, adopts
With spray drying normal direction step 1 gained inner core particle surface one layer of collagen peptide shell of spray attachment, the glue is obtained after dry
Former albumen peptide complexes.
The embedding rate of the preparation method of the collagen peptide complexes, simple process, and anthocyanin is high.Firstly,
It in the preparation process of inner core, is mixed first with anthocyanin and collagen peptide solution, realizes collagen peptide to anthocyanin
Preliminary cladding;Then, it recycles spray drying process to one layer of collagen peptide shell of inner core particle surface spray attachment, further ensures that
The embedding of anthocyanin.
The chicken embryo tire collagen peptide is prepared by following methods:
(1) it extracts: the decladding of chicken embryo tire, drying, crushing;Pure and mild protease is added in the chicken embryo tire of crushing and carries out diacolation, egg
The additional amount of white enzyme is 1 ‰, ultrasonic vibration 1h of chicken embryo tire weight, is then centrifuged for collecting upper layer percolate, percolate recycles alcohol
Liquid is simultaneously concentrated, and it is spare to obtain chicken embryo extract;
(2) it digests: hydrolase being added in the chicken embryo extract obtained in step 1, the additional amount of hydrolase is chicken embryo
The 1 ‰ of tire weight, stirring digests 6h under conditions of 40 DEG C, then enzyme deactivation, filtering, collection filtrate, in the filtrate of collection plus white
Clay and active carbon are stood, and it is spare to collect filtrate for filtration;
(3) refine: the filtrate that step 2 is collected uses membrane filter system, separates through multistage screening, remaining concentrated phase is through going out
After bacterium, concentration, drying, chicken embryo tire collagen peptide is obtained.
Innovative utilization chicken embryo tire prepares collagen peptide, and chicken embryo tire is the animal embryo not hatched before chicken, chicken
Embryo has nutriment very rich, protein rich in, 18 kinds of amino acid, various trace elements.It utilizes
Chicken embryo tire prepares collagen peptide, can not only make full use of the collagen in chicken embryo tire, but also can retain to greatest extent therein
Different kind organism active material, and all kinds of nutriments therein are also effectively extracted, and bioavilability is high, tired with resisting
Labor, the effect of improving immunity, filling blood.In the preparation process of chicken embryo tire collagen peptide, with white bole and active carbon pair
Filtrate is cleaned, eliminated the unusual smell, it can be achieved that the beneficial effect that free from extraneous odour, mouthfeel are good.
Embodiment 2
A kind of collagen peptide complexes, including inner core and the shell for being wrapped in inner core outer layer, the inner core it is main at
It is divided into anthocyanin and collagen peptide, the main component of the shell is collagen peptide.
The preparation method of above-mentioned collagen peptide complexes, comprising the following steps:
(1) prepare inner core: weigh respectively weight ratio be 0.4:1 anthocyanin freeze-dried powder and collagen peptide powder it is spare,
Anthocyanin and collagen peptide are separately added into deionized water and are uniformly mixed, anthocyanin solution and collagen peptide are respectively obtained
Anthocyanin solution is slowly added into collagen peptide solution is uniformly mixed under stirring conditions by solution for standby, concentrated freeze-dried,
It is granulated, is dry, obtaining collagen peptide cladding anthocyanin inner core particle, it is spare;
(2) it coats shell: collagen peptide being added in deionized water and is uniformly mixed, collagen peptide solution is obtained, adopts
With spray drying normal direction step 1 gained inner core particle surface one layer of collagen peptide shell of spray attachment, the glue is obtained after dry
Former albumen peptide complexes.
The embedding rate of the preparation method of the collagen peptide complexes, simple process, and anthocyanin is high.Firstly,
It in the preparation process of inner core, is mixed first with anthocyanin and collagen peptide solution, realizes collagen peptide to anthocyanin
Preliminary cladding;Then, it recycles spray drying process to one layer of collagen peptide shell of inner core particle surface spray attachment, further ensures that
The embedding of anthocyanin.
The chicken embryo tire collagen peptide is prepared by following methods:
(1) it extracts: the decladding of chicken embryo tire, drying, crushing;Pure and mild protease is added in the chicken embryo tire of crushing and carries out diacolation, surpasses
1h is swung in acoustic shock, is then centrifuged for collecting upper layer percolate, and percolate recycling alcohol liquid is simultaneously concentrated, and it is spare to obtain chicken embryo extract;
(2) it digests: hydrolase is added in the chicken embryo extract obtained in step 1, stirs enzyme under conditions of 60 DEG C
3h is solved, then enzyme deactivation, filtering, collection filtrate, adds white bole and active carbon to stand in the filtrate of collection, it is standby to collect filtrate for filtration
With;
(3) refine: the filtrate that step 2 is collected uses membrane filter system, separates through multistage screening, remaining concentrated phase is through going out
After bacterium, concentration, drying, chicken embryo tire collagen peptide is obtained.
In the step 1, the additional amount of protease is the 4 ‰ of chicken embryo tire weight;In the step 2, the addition of hydrolase
Amount is the 4 ‰ of chicken embryo tire weight.
The shell includes the raw material of following parts by weight: 60 parts of chicken embryo tire collagen peptide, 15 parts of bone collagen peptide, fish
10 parts of collagen peptide.The weight ratio of the inner core and shell is 0.6:1.The anthocyanin includes grape pericarp anthocyanin, rose
Anthocyanin, roselle anthocyanin, weight ratio 1:0.8:1.
Embodiment 3
A kind of collagen peptide complexes, including inner core and the shell for being wrapped in inner core outer layer, the inner core it is main at
It is divided into anthocyanin and collagen peptide, the main component of the shell is collagen peptide.The shell includes following parts by weight
Raw material: 50 parts of chicken embryo tire collagen peptide, 12 parts of bone collagen peptide, 12 parts of Isin glue collagen peptide.
The weight ratio of the inner core and shell is 0.4:1.The weight ratio of anthocyanin and collagen peptide is in the inner core
0.3:1.The anthocyanin is grape pericarp anthocyanin.
The chicken embryo tire collagen peptide is prepared by following methods:
(1) it extracts: the decladding of chicken embryo tire, drying, crushing;Pure and mild protease is added in the chicken embryo tire of crushing and carries out diacolation, surpasses
2h is swung in acoustic shock, is then centrifuged for collecting upper layer percolate, and percolate recycling alcohol liquid is simultaneously concentrated, and it is spare to obtain chicken embryo extract;
(2) it digests: hydrolase is added in the chicken embryo extract obtained in step 1, stirs enzyme under conditions of 50 DEG C
5h is solved, then enzyme deactivation, filtering, collection filtrate, adds white bole and active carbon to stand in the filtrate of collection, it is standby to collect filtrate for filtration
With;
(3) refine: the filtrate that step 2 is collected uses membrane filter system, separates through multistage screening, remaining concentrated phase is through going out
After bacterium, concentration, drying, chicken embryo tire collagen peptide is obtained.
In the step 1, the additional amount of protease is the 2 ‰ of chicken embryo tire weight;In the step 2, the addition of hydrolase
Amount is the 3 ‰ of chicken embryo tire weight.
Test case 1
Using the anthocyanin in the collagen peptide complexes of HPLC method detection embodiment 1, the specific steps are as follows: weigh 1g
Compound is settled in 10mL volumetric flask with distilled water, then utilizes 0.45um filtering with microporous membrane, examines side with HPLC.Comparison
Example is commercially available anthocyanin health care product.
Through detecting, after the collagen peptide complexes of the embodiment of the present invention 1 store 7 days in 40 DEG C of constant incubators, flower
Color glycosides retention rate is 92.78%, and anthocyanin retention rate is only 32.33% in comparative example.It can be seen that the present invention is by collagen egg
White peptide protects anthocyanin as shell, is greatly improved the stability of anthocyanin.
1. Anthocyanin content of table
Test case 2
By the collagen peptide complexes of embodiment 1-3, comparative example is the collagen peptide without adding anthocyanin.It is placed in
25 DEG C, preservation half a year under 85% environment of relative humidity, using " GB/T 4789.2-2010 microbiological test of food hygiene bacterium colony
Sum measurement " carry out total plate count test.Specific test result, is shown in Table 2.
2. total plate count of table tests table
Number | Total plate count (cfu/g) |
Embodiment 1 | 3.1×103 |
Embodiment 2 | 3.5×103 |
Embodiment 3 | 3.8×103 |
Comparative example | 5.2×103 |
From Table 2, it can be seen that the total plate count of collagen peptide is decreased obviously after being added to anthocyanin, product is protected
The matter phase is substantially extended.
Claims (9)
1. a kind of collagen peptide complexes, it is characterised in that: including inner core and the shell for being wrapped in inner core outer layer, the inner core
Main component be anthocyanin and collagen peptide, the main component of the shell is collagen peptide.
2. collagen peptide complexes according to claim 1, it is characterised in that: the collagen peptide includes ossein
One of protein peptides, Isin glue collagen peptide, chicken embryo tire collagen peptide or a variety of combinations.
3. collagen peptide complexes according to claim 2, which is characterized in that the chicken embryo tire collagen peptide by with
The preparation of lower section method:
(1) it extracts: the decladding of chicken embryo tire, drying, crushing;Pure and mild protease is added in the chicken embryo tire of crushing and carries out diacolation, ultrasound shake
1-3h is swung, is then centrifuged for collecting upper layer percolate, percolate recycling alcohol liquid is simultaneously concentrated, and it is spare to obtain chicken embryo extract;
(2) it digests: hydrolase is added in the chicken embryo extract obtained in step 1, stirs enzyme under conditions of 40~60 DEG C
3~6h is solved, then enzyme deactivation, filtering, collection filtrate, adds white bole and active carbon to stand in the filtrate of collection, filtrate is collected in filtration
It is spare;
(3) refine: the filtrate that step 2 is collected uses membrane filter system, separates through multistage screening, remaining concentrated phase is sterilized, dense
After contracting, drying, chicken embryo tire collagen peptide is obtained.
4. collagen peptide complexes according to claim 3, which is characterized in that in the step 1, the addition of protease
Amount is 1~the 4 ‰ of chicken embryo tire weight;In the step 2, the additional amount of hydrolase is 1~the 4 ‰ of chicken embryo tire weight.
5. collagen peptide complexes according to claim 2, which is characterized in that the shell includes following parts by weight
Raw material: 40~60 parts of chicken embryo tire collagen peptide, 10~15 parts of bone collagen peptide, 10~15 parts of Isin glue collagen peptide.
6. collagen peptide complexes according to claim 1, it is characterised in that: the weight ratio of the inner core and shell is
0.3~0.6:1.
7. collagen peptide complexes according to claim 1, it is characterised in that: anthocyanin and collagen egg in the inner core
The weight ratio of white peptide is 0.2~0.4:1.
8. collagen peptide complexes according to claim 1, it is characterised in that: the anthocyanin includes Grape Skin pattern
One of glycosides, rose anthocyanin, roselle anthocyanin or a variety of combinations.
9. the preparation method of any collagen peptide complexes of claim 1~8, which is characterized in that including following step
It is rapid:
(1) prepare inner core: weigh respectively weight ratio be 0.2~0.4:1 anthocyanin freeze-dried powder and collagen peptide powder it is spare,
Anthocyanin and collagen peptide are separately added into deionized water and are uniformly mixed, anthocyanin solution and collagen peptide are respectively obtained
Anthocyanin solution is slowly added into collagen peptide solution is uniformly mixed under stirring conditions by solution for standby, concentrated freeze-dried,
It is granulated, is dry, obtaining collagen peptide cladding anthocyanin inner core particle, it is spare;
(2) it coats shell: collagen peptide being added in deionized water and is uniformly mixed, collagen peptide solution is obtained, using spray
Mist dries normal direction step 1 gained inner core particle surface one layer of collagen peptide shell of spray attachment, obtains the collagen egg after dry
White peptide complexes.
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111334549A (en) * | 2020-02-21 | 2020-06-26 | 海南美肽生物科技有限公司 | Oyster peptide and oyster peptide extraction method |
CN112979758A (en) * | 2021-03-05 | 2021-06-18 | 扬州博科文化发展有限公司 | Polypeptide, method for preparing polypeptide anthocyanin complex by using polypeptide and application of polypeptide |
CN114794458A (en) * | 2022-03-09 | 2022-07-29 | 北京仲伊本草科技有限公司 | Ginseng and radix polygonati fine food pill and preparation method thereof |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105533713A (en) * | 2015-12-29 | 2016-05-04 | 广州市戴菊科技发展有限公司 | Medical food with anti-ageing function and preparation method of medical food |
CN106138101A (en) * | 2016-08-08 | 2016-11-23 | 山东宏济堂制药集团股份有限公司 | A kind of preparation method of Embryo Gallus domesticus extract |
-
2019
- 2019-07-03 CN CN201910596536.7A patent/CN110250510A/en active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105533713A (en) * | 2015-12-29 | 2016-05-04 | 广州市戴菊科技发展有限公司 | Medical food with anti-ageing function and preparation method of medical food |
CN106138101A (en) * | 2016-08-08 | 2016-11-23 | 山东宏济堂制药集团股份有限公司 | A kind of preparation method of Embryo Gallus domesticus extract |
Non-Patent Citations (2)
Title |
---|
孟宪军等: "《中国小浆果深加工技术》", 31 August 2012, 中国轻工业出版社 * |
杨丰绮等: "哺乳动物胶原蛋白多肽的性质及其研究进展", 《西部皮革》 * |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111334549A (en) * | 2020-02-21 | 2020-06-26 | 海南美肽生物科技有限公司 | Oyster peptide and oyster peptide extraction method |
CN112979758A (en) * | 2021-03-05 | 2021-06-18 | 扬州博科文化发展有限公司 | Polypeptide, method for preparing polypeptide anthocyanin complex by using polypeptide and application of polypeptide |
CN114794458A (en) * | 2022-03-09 | 2022-07-29 | 北京仲伊本草科技有限公司 | Ginseng and radix polygonati fine food pill and preparation method thereof |
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