CN110237206A - A kind of oral traditional Chinese medicine prescription for decrease of platelet after malignant tumor chemotherapy - Google Patents

Abstract

The invention discloses a kind of oral traditional Chinese medicine prescriptions for decrease of platelet after malignant tumor chemotherapy, are made of following weight with the Chinese medicine material of part: hairyvein agrimony 30g, fruit of glossy privet 15g, Eclipta prostrata 15g, rhizoma imperatae 20g, setose thistle 30g, field thistle 30g, Radix Notoginseng powder 10g, Radix Rehmanniae 20g, donkey-hide gelatin 20g, Radix Astragali 30g, sun-dried ginseng 20g, fructus amomi 10g, coloured malt 20g, frying rice sprout 20g.Oral drugs of the present invention are decoction, and oral solution, granule, liquid extract or pill can also be made of conventional method；For preventing and treating thrombopenia caused by chemotherapy, it may also be used for thrombopenia caused by other a variety of causes, be it is a kind of it is quick, good effect, cost price is low, have no toxic side effect for preventing and treating the oral drugs of decrease of platelet after chemotherapy.

Description

A kind of oral traditional Chinese medicine prescription for decrease of platelet after malignant tumor chemotherapy

Technical field

The present invention relates to technical field of traditional Chinese medicines, it is specially a kind of for after malignant tumor chemotherapy decrease of platelet it is oral in Medicine prescription.

Background technique

Bone marrow suppression caused by chemotherapy is clinical manifestation common in oncotherapy, and the various hematopoietic cells of marrow are through chemotherapy The chance of cell number reduction is decided by the length of its life cycle afterwards, and blood platelet half life is shorter, is 5-7d, therefore especially hold Easily reduce.When blood platelet drops to 60 × 109/L or less, human body just has hematostaxis tendency.Serious blood is small Plate reduces the further treatment for not only influencing tumour, it is also possible to lead to bleeding, or even jeopardize patient vitals.Western medical treatment is with defeated Infuse Platelets Pheresis/Apheresis platelets, thrombopoietin (TPO), based on interleukin-ll (rhlL-ll).It is transfused Platelets Pheresis/Apheresis platelets, rhlL-ll And TPO's is curative for effect, but it is due to being limited by expensive and different degree side effect, clinical generally use is compared It is limited.Therefore, the treatment method and drug for seeking high-effect less toxic side effect, can alleviate decrease of platelet degree, mitigation is faced Bed symptom, and it is cheap, there is far reaching significance for the therapeutic effect of chemotherapy-induced thrombocytopenia.

Research of the traditional Chinese medicine after preventing and treating chemotherapy in terms of decrease of platelet is quite a few, from theoretic discussion to clinical research, all Achieve many progress.Theory of pathogenesis is contended development, and clinical research deepens continuously, constantly mentions to the understanding of chemotherapy decrease of platelet It is high.Traditional Chinese medicine has the advantage of tcm treatment according to syndrome differentiation and flexile treatment means, effect preferable.Compared with Western medicine, have The advantages that acting on steady, lasting, cheap, Small side effects, and advantage and characteristic that Chinese medicine holism is controlled can be embodied.It is mentioning It while blood platelet-increasing, can also preferably improve clinical symptoms, for tumor patient, immunity of organisms can be enhanced, improve life Bioplasm amount, is with a wide range of applications.There is also many deficiencies under study for action for certain traditional Chinese medicine, although some prescriptions and single medicine It is applied repeatedly and is proved to effective extensively but its mechanism of action is not disclosed also completely, effective component, which also lacks, deeply grinds Study carefully, TCM Syndrome Type is also lack of standardization, and recipe is also to further selected, and decocting for Chinese herbal medicine trouble, poor taste.

Summary of the invention

The purpose of the present invention is to provide it is a kind of it is quick, good effect, cost price is low, have no toxic side effect for pernicious swollen The oral traditional Chinese medicine prescription of decrease of platelet after tumor chemotherapy is insufficient to solve Promoting Factors for Thrombopoiesis mentioned above in the background art The problem of.

To achieve the above object, the invention provides the following technical scheme: a kind of subtract for blood platelet after malignant tumor chemotherapy Few oral traditional Chinese medicine prescription, the Chinese medicine material including following weight fraction proportion: 2-3 parts of hairyvein agrimony, 1-2 parts of the fruit of glossy privet, 1-2 parts of Eclipta prostrata, 1-2 parts of rhizoma imperatae, 2-3 parts of setose thistle, 2-3 parts of field thistle, 0.5-1 parts of Radix Notoginseng powder, Radix Rehmanniae 1-2 Part, 1-2 parts of donkey-hide gelatin, 2-3 parts of Radix Astragali, 1-2 parts of sun-dried ginseng, 1 part of fructus amomi, 1-2 parts of coloured malt, fry rice sprout 1-2 Part.

Further, above-mentioned donkey-hide gelatin can use 0.5-1 parts of tortoise-shell glue replacements.

Further, including 3 parts of hairyvein agrimony, 2 parts of the fruit of glossy privet, 2 parts of Eclipta prostrata, 2 parts of rhizoma imperatae, 3 parts of setose thistle, field thistle 3 Part, 1 part of Radix Notoginseng powder, 2 parts of Radix Rehmanniae, 2 parts of donkey-hide gelatin, 3 parts of Radix Astragali, 2 parts of sun-dried ginseng, 1 part of fructus amomi, 2 parts of coloured malt, fry 2 parts of rice sprout.

Further, above-mentioned donkey-hide gelatin can be replaced with 1 part of tortoise-shell glue.

Further, 10 grams every part are taken to be one by above-mentioned Chinese medicine material, weigh hairyvein agrimony 30g, fruit of glossy privet 15g, It is Eclipta prostrata 15g, rhizoma imperatae 20g, setose thistle 30g, field thistle 30g, Radix Notoginseng powder 10g, Radix Rehmanniae 20g, donkey-hide gelatin 20g, Radix Astragali 30g, sun-dried Join 20g, fructus amomi 10g, coloured malt 20g, fry rice sprout 20g.

Further, including the Chinese medicine material decocting by following dosage at decoction: take hairyvein agrimony 30g, the fruit of glossy privet 15g, Eclipta prostrata 15g, rhizoma imperatae 20g, setose thistle 30g, field thistle 30g, Radix Notoginseng powder 10g, Radix Rehmanniae 20g, donkey-hide gelatin 20g, Radix Astragali 30g, Sun-dried ginseng 20g, fructus amomi 10g, coloured malt 20g, rice sprout 20g is fried, the above drug beats powder molten except donkey-hide gelatin, and Radix Notoginseng powder is taken after mixing it with water outside, Remaining each medicine mixing routinely daily 1 dose, divides 2 times, 7 dose of one course for the treatment of after herbal decoction decocting with donkey-hide gelatin, the same clothes of Radix Notoginseng powder.

Compared with prior art, the beneficial effects of the present invention are:

A kind of oral traditional Chinese medicine prescription for decrease of platelet after malignant tumor chemotherapy provided by the invention, it is former according to traditional Chinese medicine Reason, based on kidney tonifying, essence replenishing, cooling blood and hemostasis, to agitate marrow hemopoiesis, clear radically reforms to prevent chemotherapeutics " burning hot poison "；Its It is secondary, supplemented by spleen benefiting and replenishing qi and blood, keep the source of qi and blood metaplasia sufficient, adopting both clearing heat method and tonification method is consolidated and radically reformed, and modern pharmacological research also confirms that These drugs have the function of stimulating marrow hemopoiesis, promote blood platelet, are that a kind of quick, good effect, cost price are low, nontoxic Side effect for preventing and treating the oral drugs of decrease of platelet after chemotherapy.

Specific embodiment

It will be detailed below the embodiment of the present invention, however, the embodiment of the present invention is not limited thereto.Based in the present invention Embodiment, every other embodiment obtained by those of ordinary skill in the art without making creative efforts, It shall fall within the protection scope of the present invention.

In the embodiment of the present invention: a kind of oral traditional Chinese medicine prescription for decrease of platelet after malignant tumor chemotherapy being provided, is wrapped Include the Chinese medicine material of following weight fraction proportion: 2-3 parts of hairyvein agrimony, 1-2 parts of the fruit of glossy privet, 1-2 parts of Eclipta prostrata, rhizoma imperatae 1-2 parts, 2-3 parts of setose thistle, 2-3 parts of field thistle, 0.5-1 parts of Radix Notoginseng powder, 1-2 parts of Radix Rehmanniae, 1-2 parts of donkey-hide gelatin, Radix Astragali 2- 3 parts, 1-2 parts of sun-dried ginseng, 1 part of fructus amomi, 1-2 parts of coloured malt, fry rice sprout 1-2 parts, wherein donkey-hide gelatin can use 0.5-1 Part tortoise-shell glue replacement.

It in the present embodiment, is matched by above-mentioned raw materials, oral traditional Chinese medicine of the present invention can be made as decoction, mouth using conventional method Take liquid, granule, liquid extract or pill；Wherein, each component pharmacological action is as follows:

Hairyvein agrimony: bitter is puckery, return lung, liver, the spleen channel, astringing to arrest bleeding qi-restoratives；

The fruit of glossy privet: Gan Ping, liver-kidney tonifying；

Eclipta prostrata: Gan Han enters kidney and mends essence, and under energy is beneficial and in honor, three is monarch drug in a prescription altogether；

Radix Astragali: Gan Wen, invigorating qi for strengthening superficies；

Sun-dried ginseng: reinforcing vital energy, benefiting blood and tranquilizing spirit；

Donkey-hide gelatin: Gan Ping, benefiting yin of enriching blood；

Radix Rehmanniae: Gan Han, nourishing Yin and promoting production of body fluid close Radix Astragali, sun-dried ginseng nourishing qi and blood, four supplementing qi and nourishing yins, and nourishing and enriching blood has qi and blood Source is altogether ministerial drug；

Rhizoma imperatae, setose thistle, field thistle: cooling blood and hemostasis, the function of principal drug assistance hemostasis；

Fructus amomi, fries rice sprout at coloured malt: strengthening the spleen and stomach, solid protection stomach Qi help ministerial drug tonifying Qi and blood；

Radix Notoginseng powder: nourshing blood and promoting blood circulation matches with fructus amomi, can qi-regulating promoting circulation of blood to prevent stagnation of QI-blood be altogether adjutant.

The present invention treats the theoretical foundation of decrease of platelet after chemotherapy: Chinese medicine thinks that tumour is lost in yang blood and qi Damage, what the positive deficiency of vital energy occurred on the basis of declining；Chemotherapeutics belongs to cell toxicity medicament, and modern Chinese medicine is thought that chemotherapeutics belongs to and attacked The product cut down, are belonged to " fire toxin " " burning hot poison is evil " scope, body can be made to reach " heresy is gone just from peace " though chemotherapy has, it is most Common toxicity first is that bone marrow suppression, chemotherapeutic is as toxic product, while sending an expedition against internal cancer poison, also aggravate The damage of qi and blood internal organs, especially spleen kidney two are dirty, and positive gas consumption is caused to hurt, the biochemical weary source of qi and blood；Clinically it is mainly shown as all void not Foot, resistance decline；As " Plain Questions is logical to comment actual situation opinion " is said: " consumption of normal qi causing asthenia ", " Required Readings for Medical Professionals consumptive disease " are said: " being not belonging to gas Belong to blood, the vital organs of the human body not can outside here；And spleen kidney person is solely lifted, water is the source of all things on earth, and soil is the universal mother, two dirty peaces and one Body is all controlled, and hundred diseases are not given birth to "；According to principles above, prescription feature of the present invention is: (1) kidney tonifying, essence replenishing, based on cooling blood and hemostasis, with drum Dynamic marrow hemopoiesis, clear radically reforms to prevent chemotherapeutics " burning hot poison "；(2) supplemented by spleen benefiting and replenishing qi and blood, make the source of qi and blood metaplasia It is sufficient；(3) adopting both clearing heat method and tonification method is consolidated and is radically reformed, and modern pharmacological research also demonstrates that these drugs have stimulation marrow hemopoiesis, promote blood The effect of platelet.

In order to further preferably illustrate foregoing invention, also offer following examples are illustrated:

Embodiment one:

100 grams every part are taken to be one by above-mentioned Chinese medicine material, are weighed raw material and are prepared oral solution: hairyvein agrimony 300g, the fruit of glossy privet 150g, Eclipta prostrata 150g, rhizoma imperatae 200g, setose thistle 300g, field thistle 300g, Radix Notoginseng powder 60g, Radix Astragali 300g, sun-dried ginseng 150g, Radix Rehmanniae 150g, fructus amomi 100g, donkey-hide gelatin 150g, coloured malt 150g, rice sprout 150g is fried；

Preparation method: the above drug first breaks into coarse powder, is made by technical process such as extraction, purification, concentration, packing, sterilizings 1000ml oral solution, 3 times a day, 15ml every time, for clinical application.

Embodiment two:

Raw material is weighed according to following weight proportion, is fabricated to granule: 3 parts of hairyvein agrimony, 2 parts of the fruit of glossy privet, 2 parts of Eclipta prostrata, cogongrass It 2 parts of root, 3 parts of setose thistle, 3 parts of field thistle, 1 part of Radix Notoginseng powder, 2 parts of Radix Rehmanniae, 2 parts of donkey-hide gelatin, 3 parts of Radix Astragali, 2 parts of sun-dried ginseng, 1 part of fructus amomi, fries 2 parts of malt, fry 2 parts of rice sprout；

Production method: by above-mentioned each component according to the production method of granule, being fabricated to granule, 3 times a day, 9 grams every time, For clinical use.

Embodiment three:

Raw material is weighed according to following weight proportion, is fabricated to liquid extract: 3 parts of hairyvein agrimony, 2 parts of the fruit of glossy privet, Eclipta prostrata 2 Part, 2 parts of rhizoma imperatae, 3 parts of setose thistle, 3 parts of field thistle, 1 part of Radix Notoginseng powder, 2 parts of Radix Rehmanniae, 2 parts of donkey-hide gelatin, 3 parts of Radix Astragali, 2 parts of sun-dried ginseng, 1 part of fructus amomi, 2 parts of coloured malt, fry 2 parts of rice sprout.

Production method: by above-mentioned each component according to the production method of liquid extract, being fabricated to liquid extract, daily 3 times, 10 grams every time, for clinical use.

Example IV:

10 grams every part are taken to be one by above-mentioned Chinese medicine material, are made decoction: being weighed hairyvein agrimony 30g, fruit of glossy privet 15g, Eclipta prostrata 15g, rhizoma imperatae 20g, setose thistle 30g, field thistle 30g, Radix Notoginseng powder 10g, Radix Rehmanniae 20g, donkey-hide gelatin 20g, Radix Astragali 30g, sun-dried ginseng 20g, Fructus amomi 10g, coloured malt 20g, rice sprout 20g is fried.

Preparation method: the above drug beats powder molten except donkey-hide gelatin, and Radix Notoginseng powder is taken after mixing it with water outside, remaining each medicine mixing is routinely boiled medicine Daily 1 dose, divide 2 times, 7 dose of one course for the treatment of with donkey-hide gelatin, Radix Notoginseng powder with taking after method decocting.

In above-mentioned 4 embodiments, it is also possible to which tortoise-shell glue replaces donkey-hide gelatin, and dosage halves, this example is also protected in the present invention Within the scope of.

The present invention is on the basis for the treatment of the dedicated side of thrombopenia caused by a variety of causes for many years, in conjunction with change What treatment developed the hurtful pathological characteristic of human body；It will be used to prevent and treat chemotherapy by the decoction prepared in example IV and draws The decrease of platelet risen, treats over thousands of example, and from January, 2010 in June, 2018, in Tai'an, tumour hospital applies the present invention The patient of decrease of platelet after various chemotherapy of tumors did detailed observation and had keeper 326, average medication number of days 8 It, it is efficient up to 97.9%；Therefore, the present invention is in terms for the treatment of the especially blood platelet decline of the bone marrow suppression after chemotherapy, be have it is good Good clinical efficacy, shows traditional Chinese medicine in the wide application prospect in the field；

By above-mentioned 326 patients, divide prevention group and treatment group 2 groups of carry out clinical observations:

1), 166 people of prevention group: giving the decoction prepared in example IV, and daily 1 dose, 3 days before chemotherapy start to take medicine, and are within 3 weeks One course for the treatment of observes the situation of change of chemotherapy platelet count (PLT)；

2), 160 people for the treatment of group: starting to apply after chemotherapy when PLT < 80 × 109/L, gives the soup prepared in example IV Agent, daily 1 dose, 2 weeks as a treatment course, observes the situation of change of pretherapy and post-treatment platelet count (PLT).

As a result it is detailed in the following table 1:

It is efficient high that the above observation illustrates that the present invention has for thrombopenia after Prophylactic chemotherapy, guarantee chemotherapy smoothly into Row is not easy the advantages that falling after rise using rear platelet count.

More specifically, giving some instances again below proves curative effect of the invention:

Case one: XX, male, 68 years old, the court department of traditional Chinese medicine inpatient；10 after 2 period of patient's Small Cell Lung Cancer chemotherapy , repeatedly there is decrease of platelet in it during chemotherapy, using regrouping human interleukin-11, recombined human thrombopoietin etc., can rise to Normally；This 3rd period chemotherapy of row of being admitted to hospital, routine of having a blood test: PLT 80X109/L, HGB 100g/L, symptoms include: malaise, Lusterless complexion, when have blood-stained sputum, receive difference, mouth is light dull, and tongue nature is light dark, and tongue fur is thin white, thready and hesitant pulse, and differential diagnosis in tcm belongs to qi and blood and loses Void, prescription decoction add taste: hairyvein agrimony 30g, fruit of glossy privet 15g, Eclipta prostrata 15g, rhizoma imperatae 20g, setose thistle 30g, field thistle 30g, three Seven powder 10g, Radix Rehmanniae 20g, donkey-hide gelatin 20g, Radix Astragali 30g, sun-dried ginseng 20g, fructus amomi 10g, coloured malt 20g, rice sprout 20g is fried； Every dose in addition to donkey-hide gelatin beats powder molten, Radix Notoginseng powder is taken after mixing it with water, remaining each medicine mixing, routinely after herbal decoction decocting with donkey-hide gelatin, Radix Notoginseng powder With clothes, daily 1 dose, divides 2 times and warmly take；Row chemotherapy after 3 doses of medication continues to take medicine during chemotherapy, during which checks blood routine Appearance blood platelet does not decline, and continues clothes medicine-feeding 1 week after end of chemotherapy, and discharge check blood routine is normal.

Case two: king XX, female, 62 years old, the court department of traditional Chinese medicine inpatient；Ovarian cancer post operation recurrence, after 3 period of chemotherapy 11 days, routine of having a blood test of being admitted to hospital: PLT 64X109/L, symptoms include: shortness of breath and fatigue, sallow complexion, dry happiness drink, spontaneous sweating are received Slow-witted dormancy is poor, and two just adjust, the light red less fur of tongue nature, and veins string is thin and delicate；Disease belongs to nourishing kidney-yin, insufficiency of vital energy and blood, prescription decoction: hairyvein agrimony 30g, fruit of glossy privet 15g, Eclipta prostrata 15g, rhizoma imperatae 20g, setose thistle 30g, field thistle 30g, Radix Notoginseng powder 10g, Radix Rehmanniae 20g, donkey-hide gelatin 20g, Radix Astragali 30g, sun-dried ginseng 20g, fructus amomi 10g, coloured malt 20g, rice sprout 20g is fried；Every dose is beaten powder molten, Radix Notoginseng except donkey-hide gelatin Outside powder is taken after mixing it with water, remaining each medicine mixing routinely daily 1 dose, divides 2 temperature with donkey-hide gelatin, the same clothes of Radix Notoginseng powder after herbal decoction decocting Clothes after 4 doses of medication, check blood routine PLT 89X109/L, carry out the 4th period chemotherapy and continue oral top, chemotherapy After continue clothes medicine-feeding 2 weeks, check blood routine it is normal.

In summary: a kind of oral traditional Chinese medicine prescription for decrease of platelet after malignant tumor chemotherapy provided by the invention, Be made of following weight with the Chinese medicine material of part: hairyvein agrimony 30g, fruit of glossy privet 15g, Eclipta prostrata 15g, rhizoma imperatae 20g, setose thistle 30g, Field thistle 30g, it Radix Notoginseng powder 10g, Radix Rehmanniae 20g, donkey-hide gelatin 20g, Radix Astragali 30g, sun-dried ginseng 20g, fructus amomi 10g, coloured malt 20g, fries Rice sprout 20g.Oral drugs of the present invention are decoction, and oral solution, granule, liquid extract can also be made of conventional method Or pill；For preventing and treating thrombopenia caused by chemotherapy, it may also be used for thrombopenia caused by other a variety of causes.

It although an embodiment of the present invention has been shown and described, for the ordinary skill in the art, can be with A variety of variations, modification, replacement can be carried out to these embodiments without departing from the principles and spirit of the present invention by understanding And modification, the scope of the present invention is defined by the appended.

Claims (6)

1. a kind of oral traditional Chinese medicine prescription for decrease of platelet after malignant tumor chemotherapy, which is characterized in that including following weight The Chinese medicine material of score proportion: 2-3 parts of hairyvein agrimony, 1-2 parts of the fruit of glossy privet, 1-2 parts of Eclipta prostrata, 1-2 parts of rhizoma imperatae, greatly It is 2-3 parts of Ji, 2-3 parts of field thistle, 0.5-1 parts of Radix Notoginseng powder, 1-2 parts of Radix Rehmanniae, 1-2 parts of donkey-hide gelatin, 2-3 parts of Radix Astragali, sun-dried 1-2 parts of ginseng, 1-2 parts of coloured malt, fries rice sprout 1-2 parts by 1 part of fructus amomi.

2. a kind of oral traditional Chinese medicine prescription for decrease of platelet after malignant tumor chemotherapy according to claim 1, special Sign is that above-mentioned donkey-hide gelatin can use 0.5-1 parts of tortoise-shell glue replacements.

3. a kind of oral traditional Chinese medicine prescription for decrease of platelet after malignant tumor chemotherapy according to claim 1, special Sign is, including 3 parts of hairyvein agrimony, 2 parts of the fruit of glossy privet, 2 parts of Eclipta prostrata, and 2 parts of rhizoma imperatae, 3 parts of setose thistle, 3 parts of field thistle, 1 part of Radix Notoginseng powder, 2 parts of Radix Rehmanniae, 2 parts of donkey-hide gelatin, 3 parts of Radix Astragali, 2 parts of sun-dried ginseng, 1 part of fructus amomi, 2 parts of coloured malt, fry 2 parts of rice sprout.

4. a kind of oral traditional Chinese medicine prescription for decrease of platelet after malignant tumor chemotherapy according to claim 3, special Sign is that above-mentioned donkey-hide gelatin can be replaced with 1 part of tortoise-shell glue.

5. a kind of oral traditional Chinese medicine prescription for decrease of platelet after malignant tumor chemotherapy according to claim 3, special Sign is, by above-mentioned Chinese medicine material take 10 grams every part be it is one, weigh hairyvein agrimony 30g, fruit of glossy privet 15g, Eclipta prostrata 15g, white Lalang grass rhizome 20g, setose thistle 30g, field thistle 30g, Radix Notoginseng powder 10g, Radix Rehmanniae 20g, donkey-hide gelatin 20g, Radix Astragali 30g, sun-dried ginseng 20g, fructus amomi 10g, coloured malt 20g, rice sprout 20g is fried.

6. a kind of oral traditional Chinese medicine prescription for decrease of platelet after malignant tumor chemotherapy according to claim 5, special Sign is, including the Chinese medicine material decocting by following dosage at decoction: take hairyvein agrimony 30g, fruit of glossy privet 15g, Eclipta prostrata 15g, Rhizoma imperatae 20g, setose thistle 30g, field thistle 30g, Radix Notoginseng powder 10g, Radix Rehmanniae 20g, donkey-hide gelatin 20g, Radix Astragali 30g, sun-dried ginseng 20g, fructus amomi 10g, coloured malt 20g, rice sprout 20g is fried, the above drug beats powder molten except donkey-hide gelatin, and Radix Notoginseng powder is taken after mixing it with water outside, remaining each medicine mixing is pressed Daily 1 dose, divide 2 times, 7 dose of one course for the treatment of with donkey-hide gelatin, Radix Notoginseng powder with taking after conventional herbal decoction decocting.