CN110236196A - A kind of water-dispersible phytosterols mixing medicinal powder and preparation method thereof - Google Patents
A kind of water-dispersible phytosterols mixing medicinal powder and preparation method thereof Download PDFInfo
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- CN110236196A CN110236196A CN201910657071.1A CN201910657071A CN110236196A CN 110236196 A CN110236196 A CN 110236196A CN 201910657071 A CN201910657071 A CN 201910657071A CN 110236196 A CN110236196 A CN 110236196A
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- 239000000843 powder Substances 0.000 title claims abstract description 27
- 238000002156 mixing Methods 0.000 title claims abstract description 26
- 229940068065 phytosterols Drugs 0.000 title claims abstract description 25
- 238000002360 preparation method Methods 0.000 title claims abstract description 12
- 239000000203 mixture Substances 0.000 claims abstract description 19
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 17
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 16
- 150000001720 carbohydrates Chemical class 0.000 claims abstract description 15
- 230000006641 stabilisation Effects 0.000 claims abstract description 15
- 238000011105 stabilization Methods 0.000 claims abstract description 15
- 230000001804 emulsifying effect Effects 0.000 claims abstract description 14
- 150000002148 esters Chemical class 0.000 claims abstract description 13
- 235000001630 Pyrus pyrifolia var culta Nutrition 0.000 claims abstract description 11
- 240000002609 Pyrus pyrifolia var. culta Species 0.000 claims abstract description 11
- 238000001035 drying Methods 0.000 claims abstract description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 15
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 11
- 229920000053 polysorbate 80 Polymers 0.000 claims description 11
- 239000000230 xanthan gum Substances 0.000 claims description 11
- 229920001285 xanthan gum Polymers 0.000 claims description 11
- 229940082509 xanthan gum Drugs 0.000 claims description 11
- 235000010493 xanthan gum Nutrition 0.000 claims description 11
- 244000068988 Glycine max Species 0.000 claims description 10
- 235000010469 Glycine max Nutrition 0.000 claims description 10
- HVUMOYIDDBPOLL-XWVZOOPGSA-N Sorbitan monostearate Chemical group CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O HVUMOYIDDBPOLL-XWVZOOPGSA-N 0.000 claims description 7
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims description 5
- 239000007864 aqueous solution Substances 0.000 claims description 3
- 239000002253 acid Substances 0.000 claims 1
- 239000006071 cream Substances 0.000 claims 1
- 239000001587 sorbitan monostearate Substances 0.000 claims 1
- 235000011076 sorbitan monostearate Nutrition 0.000 claims 1
- 229940035048 sorbitan monostearate Drugs 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 abstract description 13
- 238000000034 method Methods 0.000 abstract description 12
- 239000006185 dispersion Substances 0.000 abstract description 8
- 239000000463 material Substances 0.000 abstract description 7
- 238000005516 engineering process Methods 0.000 abstract description 6
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- 235000013305 food Nutrition 0.000 abstract description 4
- 230000000996 additive effect Effects 0.000 abstract description 3
- 230000000694 effects Effects 0.000 abstract description 2
- 238000009472 formulation Methods 0.000 abstract description 2
- 238000005469 granulation Methods 0.000 abstract description 2
- 230000003179 granulation Effects 0.000 abstract description 2
- 230000035800 maturation Effects 0.000 abstract description 2
- 230000008569 process Effects 0.000 description 6
- 238000010438 heat treatment Methods 0.000 description 5
- 238000003756 stirring Methods 0.000 description 5
- 229930182558 Sterol Natural products 0.000 description 4
- 235000011078 sorbitan tristearate Nutrition 0.000 description 4
- 150000003432 sterols Chemical class 0.000 description 4
- 235000003702 sterols Nutrition 0.000 description 4
- 241000196324 Embryophyta Species 0.000 description 3
- IJCWFDPJFXGQBN-RYNSOKOISA-N [(2R)-2-[(2R,3R,4S)-4-hydroxy-3-octadecanoyloxyoxolan-2-yl]-2-octadecanoyloxyethyl] octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](OC(=O)CCCCCCCCCCCCCCCCC)[C@H]1OC[C@H](O)[C@H]1OC(=O)CCCCCCCCCCCCCCCCC IJCWFDPJFXGQBN-RYNSOKOISA-N 0.000 description 3
- 238000001816 cooling Methods 0.000 description 3
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- 239000012530 fluid Substances 0.000 description 3
- 238000012545 processing Methods 0.000 description 3
- 238000012216 screening Methods 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 239000001589 sorbitan tristearate Substances 0.000 description 3
- 229960004129 sorbitan tristearate Drugs 0.000 description 3
- 239000003381 stabilizer Substances 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000005485 electric heating Methods 0.000 description 2
- 238000005265 energy consumption Methods 0.000 description 2
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- 239000011259 mixed solution Substances 0.000 description 2
- 150000003431 steroids Chemical class 0.000 description 2
- WIGIZIANZCJQQY-UHFFFAOYSA-N 4-ethyl-3-methyl-N-[2-[4-[[[(4-methylcyclohexyl)amino]-oxomethyl]sulfamoyl]phenyl]ethyl]-5-oxo-2H-pyrrole-1-carboxamide Chemical compound O=C1C(CC)=C(C)CN1C(=O)NCCC1=CC=C(S(=O)(=O)NC(=O)NC2CCC(C)CC2)C=C1 WIGIZIANZCJQQY-UHFFFAOYSA-N 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 235000013361 beverage Nutrition 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000000378 dietary effect Effects 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 235000013373 food additive Nutrition 0.000 description 1
- 239000002778 food additive Substances 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 210000000232 gallbladder Anatomy 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000009776 industrial production Methods 0.000 description 1
- 239000003595 mist Substances 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000002893 slag Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 239000002351 wastewater Substances 0.000 description 1
- 238000009941 weaving Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/10—Foods or foodstuffs containing additives; Preparation or treatment thereof containing emulsifiers
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/20—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents
- A23L29/269—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of microbial origin, e.g. xanthan or dextran
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
- A23L33/11—Plant sterols or derivatives thereof, e.g. phytosterols
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/20—Agglomerating; Granulating; Tabletting
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
- B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
- B02C19/00—Other disintegrating devices or methods
- B02C19/06—Jet mills
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
- B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
- B02C23/00—Auxiliary methods or auxiliary devices or accessories specially adapted for crushing or disintegrating not provided for in preceding groups or not specially adapted to apparatus covered by a single preceding group
- B02C23/08—Separating or sorting of material, associated with crushing or disintegrating
- B02C23/16—Separating or sorting of material, associated with crushing or disintegrating with separator defining termination of crushing or disintegrating zone, e.g. screen denying egress of oversize material
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
- B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
- B02C23/00—Auxiliary methods or auxiliary devices or accessories specially adapted for crushing or disintegrating not provided for in preceding groups or not specially adapted to apparatus covered by a single preceding group
- B02C23/08—Separating or sorting of material, associated with crushing or disintegrating
- B02C23/16—Separating or sorting of material, associated with crushing or disintegrating with separator defining termination of crushing or disintegrating zone, e.g. screen denying egress of oversize material
- B02C2023/165—Screen denying egress of oversize material
Abstract
The present invention provides a kind of water-dispersible phytosterols mixing medicinal powder, it consists of the following components in terms of mass percentage: phytosterol 90%-95.3%, emulsifying saccharide stabilization agent 4.5%-8%, poly yamanashi esters emulsifier 0.2%-0.8%, and the sum of mass percent of above-mentioned each component is 100%.The present invention also provides the preparation methods of the water-dispersible phytosterols mixing medicinal powder; its rational technology realizes consecutive production using fluidized bed drying comminution granulation; production capacity is high; technique is relatively easy; technology maturation; suitable for scale, industrialized production; the water-dispersible phytosterols mixing medicinal powder as made from this method; its main component content of phytosterol is up to 90%; being related to auxiliary material is food grade additives; cheap and from a wealth of sources, additive amount is small and formulation stable, dispersion effect are good.
Description
Technical field
The present invention relates to biomedicine technical fields, and in particular to a kind of water-dispersible phytosterols mixing medicinal powder, this
Invention further relates to the preparation method of said mixture pulvis.
Background technique
Phytosterol is that have nutrition from a kind of fat-soluble white powder obtained by physical purification is passed through in corn and soybean
The features such as value is high, bioactivity is strong, can be widely used in food, medicine, cosmetics, growth of animal agent and sheet processing, print
The fields such as brush, weaving；It is especially very universal as food additives in Europe, it is widely used in food solid to reduce human body gallbladder
Alcohol；In addition, phytosterol is also important the raw materials for production of steroid drugs and vitamine D3.But the plant steroid of crystal form
Alcohol belongs to indissoluble object, and solubility in water is lower than 2mg/L, poor in the intracorporal dissolubility of people and bioavailability；And
The hydrophobicity of phytosterol, which causes by force, uses upper difficulty.
Water-dispersible phytosterols are a kind of mixtures, are to be mixed into emulsifier, stabilizer etc. in phytosterol to be combined
Pulvis.Can uniformly and stably be dispersed in water, be widely used in beverage and other water-soluble dietary systems, can dry-mixed or
It is used in the formula of instant product, is more suitable for the material composition as fermenting and producing 4-AD and forms.
The production most common method of water-dispersible phytosterols is at present:
(1) spray drying process: phytosterol and emulsifier, stabilizer etc. are uniformly mixed with water, then in about 200 DEG C of height
This mixture is atomized in warm air, flash evapn water forms pulvis.
(2) melt-blending process: being mixed and heated to 160 DEG C or more meltings uniformly for phytosterol and emulsifier, stabilizer etc.,
Block is cooled and solidified into, block is crushed and pulvis is made.
While water-dispersible phytosterols can be obtained, there is shortcoming, specifically:
(1) product formula defect is answered, and the water-dispersible phytosterols effective content generally obtained is lower than 80%, emulsifier, steady
The additive amounts such as agent are determined greater than 20%, and since content is lower, suitable application area is narrow.
(2) limited by production technology, it is necessary to be carried out at 160-200 DEG C of high temperature, since energy consumption is high, increased production cost, and deposits
In security risk.
Summary of the invention
It is an object of the present invention to provide a kind of water-dispersible phytosterols mixing medicinal powders, are granulated legal system using fluidized bed drying
It is standby at powder, content of phytosterol is up to 90% in composition.
It is a further object of the present invention to provide the preparation methods of the mixing medicinal powder, are not limited by production technology, specifically
, it is not limited by high temperature energy consumption.
The technical scheme is that a kind of water-dispersible phytosterols mixing medicinal powder, according to mass percent by following
Group is grouped as: phytosterol 90%-95.3%, emulsifying saccharide stabilization agent 4.5%-8%, poly yamanashi esters emulsifier 0.2%-
0.8%, the sum of mass percent of above-mentioned each component is 100%.
The features of the present invention also characterized in that:
Emulsifying saccharide stabilization agent is xanthan gum, and it is that 1:19 is compounded that the poly yamanashi esters emulsifier, which is according to mass ratio,
Sorbitan tristearate and polyoxyethylene sorbitan monooleate, the phytosterol be soybean phytosterol.
The mass percent of poly yamanashi esters emulsifier is 0.3%.
The mass percent of xanthan gum is 5%.
Another technical solution of the invention is the preparation method of water-dispersible phytosterols mixing medicinal powder, specifically according to
Lower step is implemented:
Step 1: the emulsifying saccharide stabilization agent that phytosterol and mass percent are 4.5%-8% being put into mixer and is carried out
Heating mixing, obtains the mixture of phytosterol Yu emulsifying saccharide stabilization agent；
Step 2: poly yamanashi esters emulsifier being dissolved in spare in hot water；
Step 3: the mixture that step 1 is obtained is put into airslide disintegrating mill and carries out air-flow crushing；
Step 4: the aqueous solution obtained to airslide disintegrating mill sprinkling step 2；
Step 5: the product that step 4 obtains is dried；
Step 6: the product that step 5 obtains being crushed, is sieved, pulvis is formed.
The features of the present invention also characterized in that:
The temperature heated in step 1 is 80 DEG C -150 DEG C.
The drying temperature of step 5 is 80 DEG C -90 DEG C.
The screen parameter that step 6 is sieved is 100 mesh.
Beneficial effects of the present invention are as follows:
(1) water-dispersible phytosterols mixing medicinal powder according to the present invention, main component content of phytosterol are up to
90% or more, being related to auxiliary material is food grade additives, cheap and from a wealth of sources, and additive amount is small and formulation stable, dispersion
It works well.
(2) technological advantage of the invention is reasonably fluidized bed drying comminution granulation to be used to realize consecutive production, production capacity
Height, technique is relatively easy, technology maturation, is suitable for scale, industrialized production.
(3) GMP workshop is built up in process according to the invention design, and production line selects equipment relatively easy, is related to material
The process points such as temperature and output carry out numerical control, and volatilization mouth is respectively connected with device for recovering powder, and whole system is closed pollution-free,
It ensure that product quality, and saved resource.Production carries out under normal circumstances, and whole process safety, health, no waste water give up
Slag generates.
Specific embodiment
The present invention will be described in detail below with reference to specific embodiments.
A kind of water-dispersible phytosterols mixing medicinal powder of the present invention, it consists of the following components in terms of mass percentage: planting
Object sterol 90%-95.3%, emulsifying saccharide stabilization agent 4.5%-8%, poly yamanashi esters emulsifier 0.2%-0.8%, it is above-mentioned each
The sum of mass percent of component is 100%.
Wherein, emulsifying saccharide stabilization agent is specially xanthan gum, and it is 1 that poly yamanashi esters emulsifier, which is specially according to mass ratio:
19 sorbitan tristearates compounded and polyoxyethylene sorbitan monooleate, phytosterol are specially that soybean is planted
Object sterol.
The water-dispersible phytosterols mixing medicinal powder preparation process is as follows:
Step 1: the emulsifying saccharide stabilization agent that phytosterol and mass percent are 4.5%-8% being put into mixer and is carried out
Heating mixing, obtains the mixture of phytosterol Yu emulsifying saccharide stabilization agent；
Wherein, the temperature of heating is 80 DEG C -150 DEG C；
Step 2: poly yamanashi esters emulsifier being dissolved in spare in hot water；
Step 3: the mixture that step 1 is obtained is put into airslide disintegrating mill and carries out air-flow crushing；
Step 4: the aqueous solution obtained to airslide disintegrating mill sprinkling step 2；
Step 5: the product that step 4 obtains is dried；
Wherein, drying temperature is 80 DEG C -90 DEG C；
Step 6: the product that step 5 obtains being crushed, is sieved, pulvis is formed；
Wherein, the screen parameter of screening is 100 mesh.
Embodiment 1:
First by 9.4700g soybean phytosterol and 0.5000g xanthan gum be put into mixer carry out heating be mixed to get plant
Then the mixture of sterol and emulsifying saccharide stabilization agent carries out air-flow crushing, after 0.0285g Tween-80 is successively weighed in flask
100g water is added in (polyoxyethylene sorbitan monooleate) and 0.0015g Span -60 (sorbitan tristearate), burns
Bottle, which is placed on electric heating cover, to be heated, and is arranged 80 DEG C of temperature, while opening stirring, revolving speed is adjusted to 80r/min；To after completely dissolution,
To the mixed solution of smashed soybean phytosterol and xanthan gum mixtures sprinkling Tween-80 and Span -60, then done
Dry processing, drying temperature are 80 DEG C, to form pulvis through crushing and screening, and 400g water is added in obtained pulvis and dilutes uniform stirring,
By observe the pulvis can stable dispersion, also can stable dispersion after cooling.
Embodiment 2:
First by 9.5300g soybean phytosterol and 0.45000g xanthan gum be put into mixer carry out heating be mixed to get plant
Then the mixture of sterol and emulsifying saccharide stabilization agent carries out air-flow crushing, after 0.0185g Tween-80 is successively weighed in flask
100g water is added in (polyoxyethylene sorbitan monooleate) and 0.0009g Span -60 (sorbitan tristearate), burns
Bottle, which is placed on electric heating cover, to be heated, and is arranged 150 DEG C of temperature, while opening stirring, revolving speed is adjusted to 80r/min；To after completely dissolution,
To the mixed solution of smashed soybean phytosterol and xanthan gum mixtures sprinkling Tween-80 and Span -60, then done
Dry processing, drying temperature are 86 DEG C, to form pulvis through crushing and screening, and 500g water is added in obtained pulvis and dilutes uniform stirring,
By observe the pulvis can stable dispersion, also can stable dispersion after cooling.
Embodiment 3:
94.700g soybean phytosterol is weighed in beaker, is mixed into 0.285g Tween-80 and 0.015g Span -60；It opens
Electric jacket is arranged 150 DEG C of temperature, heats in beaker mixture to whole meltings；It is poured into after stirring fusant 30min with glass bar
Stainless steel assorted cold dishes, assorted cold dishes placement refrigerator-freezer freezing moment are frozen into block；It weighs 5.000g xanthan gum to mix with block, add
Pulvis is made into airslide disintegrating mill.It takes pulvis 10g to be slowly added into 80 DEG C of hot water of 100g, is stirred evenly, added with glass bar
400g water dilution uniformly after be transferred in graduated cylinder, by observation can stable dispersion, also can stable dispersion after cooling.
Embodiment 4:
In industrial production use process, the soybean phytosterol of 900kg is put into mixer 1 in advance by early period, is added
50kg xanthan gum is opened mixer and is mixed, timing 1h；80 DEG C of water of 27kg, 2.85kg are successively put into dissolvers simultaneously
Tween-80 and Span -60 0.15kg are opened dissolvers and are dissolved, timing 0.5h.After the completion of preliminary preparation, gas is opened
Flow pulverizer, open fluid bed dryer, be arranged 80-90 DEG C of drying temperature, in mixer material through air-flow crushing motor spindle into
Material mouth continuity enters, and inlet amount controls 200kg/h；Sprinkler uniformly sprays dissolution through airslide disintegrating mill top feed mouth simultaneously
Solution in device, fountain height control 6.01kg/h, and under strong air flow effect, material is broken into micro mist and is sufficiently mixed with solution.It connects
Broken mixture through airslide disintegrating mill discharge port it is successional enter fluid bed dryer, inlet amount control 200kg/h,
Continuity evaporates moisture content, collects to obtain dry powder in fluid bed dryer discharge port.The powder then dried out passes through pulverizer
It is sieved, all forms pulvis by 100 mesh screens, be stably dispersed in water through test dust.
Preferably fluidized bed drying is used to be granulated by analysis supplementary material character and physicochemical property, design technology scheme, the present invention
Method prepares the water-dispersible phytosterols mixing medicinal powder.
Claims (8)
1. a kind of water-dispersible phytosterols mixing medicinal powder, which is characterized in that it consists of the following components in terms of mass percentage:
Phytosterol 90%-95.3%, emulsifying saccharide stabilization agent 4.5%-8%, poly yamanashi esters emulsifier 0.2%-0.8%, it is above-mentioned
The sum of mass percent of each component is 100%.
2. a kind of water-dispersible phytosterols mixing medicinal powder according to claim 1, which is characterized in that the carbohydrate cream
Change stabilization agent is xanthan gum, and it is sorbitan monostearate that 1:19 is compounded that the poly yamanashi esters emulsifier, which is according to mass ratio,
Acid esters and polyoxyethylene sorbitan monooleate, the phytosterol are soybean phytosterol.
3. a kind of water-dispersible phytosterols mixing medicinal powder according to claim 2, which is characterized in that the poly- sorb
The mass percent of ester emulsifying agent is 0.3%.
4. a kind of water-dispersible phytosterols mixing medicinal powder according to claim 2, which is characterized in that the xanthan gum
Mass percent be 5%.
5. the preparation method of water-dispersible phytosterols mixing medicinal powder described in -4 according to claim 1, which is characterized in that tool
Body follows the steps below to implement:
Step 1: phytosterol being put into mixer with mass percent for the emulsifying saccharide stabilization agent of 4.5%-8% and is heated
Mixing, obtains the mixture of phytosterol Yu emulsifying saccharide stabilization agent；
Step 2: poly yamanashi esters emulsifier being dissolved in spare in hot water；
Step 3: the mixture that step 1 is obtained is put into airslide disintegrating mill and carries out air-flow crushing；
Step 4: the aqueous solution obtained to airslide disintegrating mill sprinkling step 2；
Step 5: the product that step 4 obtains is dried；
Step 6: the product that step 5 obtains being crushed, is sieved, pulvis is formed.
6. the preparation method of water-dispersible phytosterols mixing medicinal powder according to claim 5, which is characterized in that described
In step 1.
7. the preparation method of water-dispersible phytosterols mixing medicinal powder according to claim 5, which is characterized in that described
The drying temperature of step 5 is 80 DEG C -90 DEG C.
8. the preparation method of water-dispersible phytosterols mixing medicinal powder according to claim 5, which is characterized in that described
The screen parameter that step 6 is sieved is 100 mesh.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910657071.1A CN110236196A (en) | 2019-07-19 | 2019-07-19 | A kind of water-dispersible phytosterols mixing medicinal powder and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201910657071.1A CN110236196A (en) | 2019-07-19 | 2019-07-19 | A kind of water-dispersible phytosterols mixing medicinal powder and preparation method thereof |
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| CN110236196A true CN110236196A (en) | 2019-09-17 |
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ID=67893122
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| CN201910657071.1A Pending CN110236196A (en) | 2019-07-19 | 2019-07-19 | A kind of water-dispersible phytosterols mixing medicinal powder and preparation method thereof |
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| CN (1) | CN110236196A (en) |
Cited By (2)
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| CN115969036A (en) * | 2023-01-10 | 2023-04-18 | 丰益油脂科技有限公司 | Particulate plant sterol and preparation method thereof |
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