CN104906129A - Calcium carbonate tablet and preparation method thereof - Google Patents
Calcium carbonate tablet and preparation method thereof Download PDFInfo
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- CN104906129A CN104906129A CN201510327241.1A CN201510327241A CN104906129A CN 104906129 A CN104906129 A CN 104906129A CN 201510327241 A CN201510327241 A CN 201510327241A CN 104906129 A CN104906129 A CN 104906129A
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Abstract
The invention discloses a calcium carbonate tablet and a preparation method of the calcium carbonate tablet. The calcium carbonate tablet comprises the following components in parts by mass: 45-55 parts of calcium carbonate, 0.5-1.5 parts of starch, 5-10 parts of granulated sugar, 0.5-1 part of peach gum and 6-12 parts of magnesium stearate. The calcium carbonate tablet prepared by the method is obvious in effect, stable in property, simple in preparation method, few in preparation processes and low in cost.
Description
Technical field
The present invention relates to drug world, particularly relate to calcium carbonate tablet and preparation method thereof.
Background technology
Calcium is mainly present in skeleton in vivo, tooth.In human body 99% calcareously exist in skeleton tooth, support motion and the masticatory ability of human body.
For different crowd, the performance of its calcium deficiency is also different.
Child: not easily fall asleep, not easily enter deep sleep, like after falling asleep to cry, easily wake up with a start, hyperhidrosis after falling asleep, paroxysmal abdominal pain, diarrhoea, constipation, skin problem, cramp, breastbone pain, " X " type lower limb, " O " type lower limb, pigeon chest, fingernail is greyish white or have white trace; Anorexia, monophagia, agitation, be on tenterhooks, intelligent development late, late, late, the teething evening of learning to walk of speaking, tooth arrangement be sparse, irregular, not closely, tooth darkly pointed or zigzag, hair sparse, occur that pillow is bald, immune, bowel problems, mental retardation, easy to catch cold etc.
Teenager: teenager calcium deficiency can be felt obvious immunity degradation, has a pain in the leg, lower limb is soft, knot, weak, irritated, energy is not concentrated, easily tired, monophagia, anorexia, decayed tooth, hypoplasia of tooth, easy allergy, easy catching a cold etc.
Between twenty and fifty: bowel problems, immunity degradation, regular asthenia, weak, knot, ache all over, the easy symptom such as allergy, easy catching a cold.
Women: bowel problems, mottle acne, odontoseisis, myasthenia of limbs, often knot, numb, ache all over, arthritis, arthritis pain, dizziness, and when suffering from anemia, antenatal hypertensive syndrome, edema and galactopoiesis deficiency, just should be diagnosed as calcium deficiency.
Old people: senile dermatosis is itched; Bowel problems, immunity degradation, heel ache, lumbar vertebra, skelalgia, arthralgia, cervical vertebra ache, odontoseisis, come off, significantly hunchback, height reduction, loss of appetite, digestive tract ulcer, constipation, dreaminess, insomnia, agitation, night sweat, cramp, irritability, fatiguability etc.
Anemia of pregnant woman: Leg Cramps, odontoseisis, Pregnancy induced hypertension, joint, pelvic pain, immunity degradation, bowel problems etc.
Being replenished the calcium by medicine is modal mode of replenishing the calcium at present, but existing calcium supplementing product, its effect is also not obvious, and unstable properties, complicated process of preparation, flow process are many.
Therefore, prior art has yet to be improved and developed.
Summary of the invention
In view of above-mentioned the deficiencies in the prior art, the object of the present invention is to provide calcium carbonate tablet and preparation method thereof, be intended to solve the existing problems such as medicine effect is not obvious, unstable properties, complex process, flow process are many of replenishing the calcium.
Technical scheme of the present invention is as follows:
Calcium carbonate tablet, wherein, by mass parts, comprising:
Carbonic acid Ca45 ~ 55 part;
Starch 0.5 ~ 1.5 part;
Saccharum Sinensis Roxb. 5 ~ 10 parts;
Resina persicae 0.5 ~ 1 part;
Magnesium stearate 6 ~ 12 parts.
Described calcium carbonate tablet, wherein, by mass parts, comprising:
Calcium carbonate 50 parts;
Starch 1 part;
Saccharum Sinensis Roxb. 7.8 parts;
Resina persicae 0.72 part;
Magnesium stearate 6 parts.
A preparation method for calcium carbonate tablet as above, wherein, comprises step:
A, dressing sieve: starch and calcium carbonate are pulverized, then cross 80 mesh sieves, for subsequent use; Magnesium stearate is pulverized, then crosses 120 mesh sieves, for subsequent use;
The preparation of B, binding agent:
The preparation of syrup: after purified water 5.2 parts being put into punching slurry tank heated and boiled, add Saccharum Sinensis Roxb., and stir, make syrup, for subsequent use;
The preparation of rubber cement: purified water 11.28 parts is put into punching slurry tank, add Resina persicae, soak 4 hours, then heats punching slurry tank and stirs, making rubber cement, for subsequent use;
Syrup rubber cement mixes: above-mentioned syrup and rubber cement dropped in punching slurry tank and stir, crossing 120 mesh sieves must mix slurry, let cool 45-50 DEG C for subsequent use;
C, to be dry mixed and wet mixing: the calcium carbonate crushed and starch are dropped into sequentially in granulator, be dry mixed 15 minutes, to add described mixing slurry after shutdown, wet mixing 5-8 second, stir to obtain treating material;
D, granule processed: above-mentioned treating material is made wet granular with 12 order stainless steel meshs on granulation machine;
E, drying: the wet granular made is moved in boiling drier, dry 30-40 minute, temperature controls at 60-75 DEG C, takes out, treats granulate;
F, granulate: dried granule 12 eye mesh screens are carried out granulate;
G, batch mixed: by obtained granule with cross the magnesium stearate be sieved and put in mixer, mix 15 minutes, shutdown blanking;
H, tabletting: loaded in tablet machine hopper by batch mixed granule, first adjust loading, then regulate pressure to carry out tabletting.
4, the preparation method of calcium carbonate tablet according to claim 3, is characterized in that, the mixer adopted in described step G is two-dimensional mixing machine.
5, the preparation method of calcium carbonate tablet according to claim 3, is characterized in that, the mixer rotating speed that described step G adopts is 10-14rpm.
Beneficial effect: calcium carbonate tablet provided by the present invention and preparation method thereof, it adopts carbonic acid Ca45 ~ 55 part; Starch 0.5 ~ 1.5 part; Saccharum Sinensis Roxb. 5 ~ 10 parts; Resina persicae 0.5 ~ 1 part; The formula that magnesium stearate is 6 ~ 12 parts, prepared product efficacy is obvious, stable performance, and technique is simple, and flow process is few, and cost is low.
Detailed description of the invention
The invention provides calcium carbonate tablet and preparation method thereof, for making object of the present invention, technical scheme and effect clearly, clearly, the present invention is described in more detail below.Should be appreciated that specific embodiment described herein only in order to explain the present invention, be not intended to limit the present invention.
Calcium carbonate tablet provided by the invention, by mass parts, comprising:
Carbonic acid Ca45 ~ 55 part;
Starch 0.5 ~ 1.5 part;
Saccharum Sinensis Roxb. 5 ~ 10 parts;
Resina persicae 0.5 ~ 1 part;
Magnesium stearate 6 ~ 12 parts.
Further, described calcium carbonate tablet, by mass parts, comprising:
Calcium carbonate 50 parts;
Starch 1 part;
Saccharum Sinensis Roxb. 7.8 parts;
Resina persicae 0.72 part;
Magnesium stearate 6 parts.
The present invention also provides a kind of preparation method of calcium carbonate tablet as above, and it comprises step:
A, dressing sieve: starch and calcium carbonate are pulverized, then cross 80 mesh sieves, for subsequent use; Magnesium stearate is pulverized, then crosses 120 mesh sieves, for subsequent use;
The preparation of B, binding agent:
The preparation of syrup: after purified water 5.2 parts being put into punching slurry tank heated and boiled, add Saccharum Sinensis Roxb., and stir, make syrup, for subsequent use;
The preparation of rubber cement: purified water 11.28 parts is put into punching slurry tank, add Resina persicae, soak 4 hours, then heats punching slurry tank and stirs, making rubber cement, for subsequent use;
Syrup rubber cement mixes: above-mentioned syrup and rubber cement dropped in punching slurry tank and stir, crossing 120 mesh sieves must mix slurry, let cool 45-50 DEG C for subsequent use;
C, to be dry mixed and wet mixing: the calcium carbonate crushed and starch are dropped into sequentially in granulator, be dry mixed 15 minutes, to add described mixing slurry after shutdown, wet mixing 5-8 second, stir to obtain treating material;
D, granule processed: above-mentioned treating material is made wet granular with 12 order stainless steel meshs on granulation machine;
E, drying: the wet granular made is moved in boiling drier, dry 30-40 minute, temperature controls at 60-75 DEG C, takes out, treats granulate;
F, granulate: dried granule 12 eye mesh screens are carried out granulate;
G, batch mixed: by obtained granule with cross the magnesium stearate be sieved and put in mixer, mix 15 minutes, shutdown blanking; The mixer adopted in described step G is preferably two-dimensional mixing machine.The mixer rotating speed that described step G adopts is preferably 10-14rpm(r/min).
H, tabletting: loaded in tablet machine hopper by batch mixed granule, first adjust loading, then regulate pressure to carry out tabletting.
Embodiment 1
Calcium carbonate 50kg;
Starch 1 kg;
Saccharum Sinensis Roxb. 7.8 kg;
Resina persicae 0.72 kg;
Magnesium stearate 6 kg.
Embodiment 2
Calcium carbonate 45kg;
Starch 1.5kg;
Saccharum Sinensis Roxb. 5 kg;
Resina persicae 1 kg;
Magnesium stearate 9kg.
Embodiment 3
Calcium carbonate 55kg;
Starch 0.5kg;
Saccharum Sinensis Roxb. 10 kg;
Resina persicae 0.5 kg;
Magnesium stearate 12 kg.
By the formula of embodiment 1, prepare as follows:
1 dressing sieve
Use pulverizer (TF-350 dust-free pulverizing mill) to pulverize respectively 1kg starch, 50kg calcium carbonate, then cross 80 mesh sieves; Pulverized by 6 kg magnesium stearate pulverizer (TF-350 dust-free pulverizing mill), then cross 120 mesh sieves, the medicated powder after sieving is respectively charged in cleaning bag, sealing, sticks material mark;
The preparation of 2 binding agents:
The preparation of syrup: after purified water 5.2kg being put into punching slurry tank heated and boiled, adds Saccharum Sinensis Roxb. 7.8kg and stirs (opening stirring paddle to entirely molten), making 13kg syrup (mass percent is 60%).
The preparation of rubber cement: purified water 11.28kg is put into punching slurry tank, add Resina persicae 0.72kg, soak 4 hours, then heats punching slurry tank and stirs (opening stirring paddle is stirred to entirely molten), making 12kg rubber cement (mass percent is 6%).
Syrup rubber cement mixing: 13kg syrup and 12kg rubber cement input punching slurry tank interior (startup stirring paddle) stir to obtain to mix and starch, and cross 120 mesh sieves, put into stainless steel cask, stick material mark, let cool 45-50 DEG C (as 48 DEG C) for subsequent use.
3 are dry mixed and wet mixing
Calcium carbonate 50kg, starch 1kg are dropped into sequentially in granulator (efficient wet granulator), be dry mixed 15 minutes, the mixing slurry 25kg, the wet mixing 5-8 that add 48 DEG C after shutdown (open stirring paddle and granulating cutter, second after first low speed at a high speed, as 8 seconds), after stirring, prepare charge cask at discharging opening, open discharging opening, after material all picks out, close material receiving port and obtain pending material;
4 granules processed: above make wet granular with 12 order stainless steel meshs at granulation machine (oscillating granulator);
5 is dry: move in boiling drier by the wet granular made, dry 30-40 minute, temperature controls at 60-75 DEG C (as 70 DEG C), takes out, treat granulate.
6 granulate: dried granule 12 eye mesh screens (in oscillating granulator) are carried out granulate, the granule after granulate loads in cleaning bag, and sealing weighs, and sticks material mark.
7 batches are mixed: by obtained granule with cross the magnesium stearate 6kg that is sieved and put in (two dimensional motion) mixer, and rotating speed is adjusted to 10-14rpm(as 12rpm), start mixing 15 minutes, shuts down blanking, installs, weigh with the container of cleaning, sticks material mark;
The inspection of two-dimensional motion mixer: switch on power, starting two-dimensional motion mixer no-load running should be normal.
8 tablettings: by batch mixed granule, load in tablet machine hopper, first adjust loading, then regulate pressure, after reaching requirement, can formally start shooting according to granule content conversion sheet weight sheet, hardness and outward appearance.In tableting processes, detect once sheet weight every 30 minutes, weigh sheet weight at any time, guarantee average sheet weight, the slice, thin piece pressed loads in clean container weighs, and sticks bucket label.
Described tablet machine is Highspeedrotarytabletpress, and it answers precheck: getting specification from punch die room is the shallow circle punching of φ 11.5mm, and after installing drift, regulator solution is depressed into 3.0-5.0Mpa, speed 7-8 ten thousand slices/hour.Switch on power, starting Highspeedrotarytabletpress no-load running should be normal.
Should be understood that, application of the present invention is not limited to above-mentioned citing, for those of ordinary skills, can be improved according to the above description or convert, and all these improve and convert the protection domain that all should belong to claims of the present invention.
Claims (5)
1. calcium carbonate tablet, is characterized in that, by mass parts, comprising:
Carbonic acid Ca45 ~ 55 part;
Starch 0.5 ~ 1.5 part;
Saccharum Sinensis Roxb. 5 ~ 10 parts;
Resina persicae 0.5 ~ 1 part;
Magnesium stearate 6 ~ 12 parts.
2. calcium carbonate tablet according to claim 1, is characterized in that, by mass parts, comprising:
Calcium carbonate 50 parts;
Starch 1 part;
Saccharum Sinensis Roxb. 7.8 parts;
Resina persicae 0.72 part;
Magnesium stearate 6 parts.
3. a preparation method for calcium carbonate tablet as claimed in claim 1, is characterized in that, comprises step:
A, dressing sieve: starch and calcium carbonate are pulverized, then cross 80 mesh sieves, for subsequent use; Magnesium stearate is pulverized, then crosses 120 mesh sieves, for subsequent use;
The preparation of B, binding agent:
The preparation of syrup: after purified water 5.2 parts being put into punching slurry tank heated and boiled, add Saccharum Sinensis Roxb., and stir, make syrup, for subsequent use;
The preparation of rubber cement: purified water 11.28 parts is put into punching slurry tank, add Resina persicae, soak 4 hours, then heats punching slurry tank and stirs, making rubber cement, for subsequent use;
Syrup rubber cement mixes: above-mentioned syrup and rubber cement dropped in punching slurry tank and stir, crossing 120 mesh sieves must mix slurry, let cool 45-50 DEG C for subsequent use;
C, to be dry mixed and wet mixing: the calcium carbonate crushed and starch are dropped into sequentially in granulator, be dry mixed 15 minutes, to add described mixing slurry after shutdown, wet mixing 5-8 second, stir to obtain treating material;
D, granule processed: above-mentioned treating material is made wet granular with 12 order stainless steel meshs on granulation machine;
E, drying: the wet granular made is moved in boiling drier, dry 30-40 minute, temperature controls at 60-75 DEG C, takes out, treats granulate;
F, granulate: dried granule 12 eye mesh screens are carried out granulate;
G, batch mixed: by obtained granule with cross the magnesium stearate be sieved and put in mixer, mix 15 minutes, shutdown blanking;
H, tabletting: loaded in tablet machine hopper by batch mixed granule, first adjust loading, then regulate pressure to carry out tabletting.
4. the preparation method of calcium carbonate tablet according to claim 3, is characterized in that, the mixer adopted in described step G is two-dimensional mixing machine.
5. the preparation method of calcium carbonate tablet according to claim 3, is characterized in that, the mixer rotating speed that described step G adopts is 10-14rpm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201510327241.1A CN104906129A (en) | 2015-06-15 | 2015-06-15 | Calcium carbonate tablet and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510327241.1A CN104906129A (en) | 2015-06-15 | 2015-06-15 | Calcium carbonate tablet and preparation method thereof |
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| CN104906129A true CN104906129A (en) | 2015-09-16 |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105996052A (en) * | 2016-07-01 | 2016-10-12 | 福建省力菲克药业有限公司 | Healthcare food for improving bone mineral density and preparation method thereof |
| CN106038620A (en) * | 2016-07-11 | 2016-10-26 | 山西普德药业有限公司 | Ginkgo leaf tablet preparing method |
| CN106562990A (en) * | 2016-11-12 | 2017-04-19 | 姚莉 | Preparation method for compound calcium tablets |
| CN107281218A (en) * | 2017-06-21 | 2017-10-24 | 吉林万通药业有限公司 | A kind of high-selenium corn is combined calcium-supplementing preparation and preparation method thereof |
| CN109112232A (en) * | 2018-08-13 | 2019-01-01 | 兴义市黔农居养种植农民专业合作社 | It is a kind of to crystallize uniform brown sugar and preparation method thereof |
| CN110122880A (en) * | 2019-06-19 | 2019-08-16 | 安徽康博特保健食品有限公司 | A kind of calcium and magnesium piece health food and preparation method thereof |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105996052A (en) * | 2016-07-01 | 2016-10-12 | 福建省力菲克药业有限公司 | Healthcare food for improving bone mineral density and preparation method thereof |
| CN106038620A (en) * | 2016-07-11 | 2016-10-26 | 山西普德药业有限公司 | Ginkgo leaf tablet preparing method |
| CN106038620B (en) * | 2016-07-11 | 2019-09-17 | 山西普德药业有限公司 | A kind of preparation method of Folium Ginkgo |
| CN106562990A (en) * | 2016-11-12 | 2017-04-19 | 姚莉 | Preparation method for compound calcium tablets |
| CN107281218A (en) * | 2017-06-21 | 2017-10-24 | 吉林万通药业有限公司 | A kind of high-selenium corn is combined calcium-supplementing preparation and preparation method thereof |
| CN107281218B (en) * | 2017-06-21 | 2020-11-17 | 吉林万通药业有限公司 | High-absorption composite calcium supplement preparation and preparation method thereof |
| CN109112232A (en) * | 2018-08-13 | 2019-01-01 | 兴义市黔农居养种植农民专业合作社 | It is a kind of to crystallize uniform brown sugar and preparation method thereof |
| CN110122880A (en) * | 2019-06-19 | 2019-08-16 | 安徽康博特保健食品有限公司 | A kind of calcium and magnesium piece health food and preparation method thereof |
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Application publication date: 20150916 |