CN110233094A - Ion source and its working method, application - Google Patents
Ion source and its working method, application Download PDFInfo
- Publication number
- CN110233094A CN110233094A CN201910626284.8A CN201910626284A CN110233094A CN 110233094 A CN110233094 A CN 110233094A CN 201910626284 A CN201910626284 A CN 201910626284A CN 110233094 A CN110233094 A CN 110233094A
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- China
- Prior art keywords
- groove
- ion source
- protrusion
- pair
- matrix
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 title claims abstract description 15
- 239000011159 matrix material Substances 0.000 claims abstract description 39
- 230000000903 blocking effect Effects 0.000 claims description 27
- 239000007787 solid Substances 0.000 claims 1
- 238000001514 detection method Methods 0.000 abstract description 3
- 238000001819 mass spectrum Methods 0.000 description 5
- 239000000523 sample Substances 0.000 description 4
- 238000004458 analytical method Methods 0.000 description 3
- 239000007921 spray Substances 0.000 description 3
- 238000005507 spraying Methods 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 239000011810 insulating material Substances 0.000 description 2
- 238000004949 mass spectrometry Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000012488 sample solution Substances 0.000 description 2
- 238000010183 spectrum analysis Methods 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000005684 electric field Effects 0.000 description 1
- 238000000132 electrospray ionisation Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 238000002203 pretreatment Methods 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
Classifications
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/10—Ion sources; Ion guns
- H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
- H01J49/165—Electrospray ionisation
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/10—Ion sources; Ion guns
- H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
- H01J49/165—Electrospray ionisation
- H01J49/167—Capillaries and nozzles specially adapted therefor
Abstract
The present invention provides a kind of ion source and its working method, application, the ion source includes capillary and discharge electrode；Matrix has ontology and extension；One end of capillary is fixed in the extension, and the other end stretches out extension；One end of discharge electrode is exposed in the first groove of ontology, and the other end is in the capillary；Guide part includes upper and bottom section setting up and down；The downside of upper part has the second groove, and connection electrode extends in the second groove；Lower part has the third groove being oppositely arranged with second groove；Third groove includes the first part set gradually, slope and second part, and the second part is higher than first part；Distance between the upper wall and third groove bottom wall of second part is not less than the thickness.The present invention has many advantages, such as that good reliability, at low cost, easy to operate, detection collimation is good.
Description
Technical field
The present invention relates to ion sources, in particular to ion source and its working method, application.
Background technique
Electric spray ion source (Electron Spray Ionization) in recent years in mass spectrometry applications more extensively, fit
The analysis of the compound slightly smaller for polarity can be used for the analysis of the macromoleculars such as polypeptide and albumen, and Ionization Efficiency is high,
It is spraying to stablize, but it also has pre-treatment slightly complicated, there are problems that sample absorption and dead volume.It is conventional in addition to nano-esi
Demand of the esi to sample size is larger, less economical.
In this context, pulse direct current ion source (PDESI) is come into being, quiet by applying high direct voltage generation to electrode
The mode of electric field makes testing liquid pulsing formula electro-spray ionization.
By adjusting the voltage strength applied, the control of Pulsed-Electrospray frequency is realized, which can effectively solve the problem that
Dead volume existing for traditional electrospray ion source and sample absorption problem, and the economy of sample is substantially increased, greatly drop
The low spraying flow velocity of electron spray, extends the spraying duration of electron spray, sufficiently ensures the analysis requirement of tandem mass spectrum.But
The ion source still has Shortcomings, such as:
It is difficult to replace capillary needle, the tip of capillary is not protected, and misoperation is easily damaged, and installs PDESI every time
Position is fixed on to mobile station not know to cause detection collimation poor, and is taken a long time.
Summary of the invention
To solve the deficiency in above-mentioned prior art, the present invention provides a kind of good reliability, it is at low cost, with it is other
Mass spectrum suitability is good, ion source easy to operate.
The purpose of the present invention is what is be achieved through the following technical solutions:
A kind of ion source, the ion source include capillary and discharge electrode；The ion source further include:
Matrix, described matrix have ontology and extension, insulate between the discharge electrode and matrix；The one of the capillary
End is fixed in the extension, and the other end stretches out extension；The ontology has the first groove, one end of the discharge electrode
It is exposed in first groove, the other end is in the capillary；
Guide part, the guide part include upper and bottom section setting up and down；The downside of the upper part has the
Two grooves, connection electrode are arranged on the upper part and extend in the second groove；The lower part has and described second
The third groove that groove is oppositely arranged；The third groove includes the first part set gradually, slope and second part, described
Second part is higher than first part；Distance between the upper wall of the second part and the third groove bottom wall is not less than described
The thickness of body.
The object of the invention is also to provide application of the above-mentioned ion source in pulse direct current ion source.
The object of the invention is also to provide the working method of above-mentioned ion source, which is by following technology
What scheme was achieved:
According to the working method of above-mentioned ion source, the working method the following steps are included:
(A1) first part being placed on described matrix in third groove；
(A2) described matrix is pushed, matrix slides onto slope, into second part；
Connection electrode and described matrix relatively move；
(A3) connection electrode enters in the first groove, contacts with the discharge electrode in the first groove；Described matrix is stuck in institute
It states between second part and the second groove.
Compared with prior art, the device have the advantages that are as follows:
1. good reliability；
By setting first part, the second part that height does not wait for third groove, and by sloped transition, so that base
Body is firmly stuck between second part and the second groove and (will not shake in up and down direction), and (in the lateral direction) is hindered
Gear, improves matrix namely the fixed reliability of capillary, has correspondingly improved the accuracy of subsequent mass spectral analysis；
2. structure is simple；
Matrix and capillary, discharge electrode can be once-forming, such as fixed capillary and discharge electrode, pouring insulating materials
, it is at low cost, it is easily manufactured quick；
Guide part uses upper and lower detachable structure, manufacture and assembly easy to process；
3. suitability is good；
This ion source can be with existing most of mass spectrometry, the lossless original source ESI of replacement mass spectrum, using with three-dimensional mobile
The mass spectrometer interface of platform is fixed, and is borrowed mass spectrum ESI high pressure or using included control box high pressure, can be operated；
4. it is easy to operate, it is put into the groove of guide part, is pushed into designated position instead of insert action, has fool-proof design, keep away
Exempt from operation error damage mass spectrum and PDESI ion source needle point；
5. capillary, matrix, discharge electrode form medical disposable material, and inexpensive is single without being individually replaced capillary
Consumptive material is disposable less than 3 yuan, convenient and efficient；
6. detecting, collimation is good, and rigid being stably connected with ensures detection collimation between each device, and average RSD value exists
In 3%-10%.
Detailed description of the invention
Referring to attached drawing, the disclosure of the present invention will become more readily understood.Skilled addressee readily understands that: this
It is only used to illustrate the technical scheme of the present invention for a little attached drawings, and is not intended to limit the scope of protection of the present invention.
In figure:
Fig. 1 is the structure diagram of ion source according to an embodiment of the present invention；
Fig. 2 is the diagrammatic cross-sectional view of ion source according to an embodiment of the present invention；
Fig. 3 is another diagrammatic cross-sectional view of ion source according to an embodiment of the present invention.
Specific embodiment
Fig. 1-3 and following description describe optional embodiments of the invention to instruct how those skilled in the art implement
It is of the invention with reproducing.In order to teach the technical scheme of the invention, it has simplified or omitted some conventional aspects.Those skilled in the art
It should be understood that the variation or replacement from these embodiments will within the scope of the invention.Those skilled in the art should understand that
The following features can be combined in various ways to form multiple variations of the present invention.As a result, the invention is not limited to it is following can
Embodiment is selected, and is only limited by the claims and their equivalents.
Embodiment 1:
Fig. 1-3 schematically illustrates the structure diagram of the ion source of the embodiment of the present invention 1, as shown in Figure 1-3, it is described from
Component includes:
The outer diameter of capillary 32 and discharge electrode 31, the capillary 32 is 1mm-2mm, and internal diameter 0.5mm-1.5mm is put
The diameter of electrode 31 is 0.2mm-1mm；
Matrix has ontology 11 and extension 12 using the matrix of insulating materials；One end of the capillary 32 is fixed on
In the extension 12, the other end stretches out extension 12；The ontology has the first groove 21 and the 4th groove 22, the electric discharge
One end of electrode 31 is exposed in first groove 21, and the other end is through and out the extension 12, and the electric discharge is electric
Pole 31 is in the capillary 32；4th groove 22 along the extending direction for being parallel to the discharge electrode 31 direction
Extend, end is connected to first groove 21, so that connection electrode 31 relatively moves in the 4th groove 22 to first
In groove 21, and contacted with discharge electrode 31；
Guide part passes through screw as shown in figure 3, the guide part includes upper part 51 and lower part 52 setting up and down
Upper part 51 and lower part 52 are fixed together by equal connectors, can be easy to disassemble；The downside of the upper part 51 has second
Groove 71, connection electrode 61 is arranged in upper part, and extends in second groove 71；Lower part 52 has and described second
The third groove 81 that groove 71 is oppositely arranged, third groove 81 include being successively set on first part 811, slope 812 and second
The height of part 813, second part 813 is higher than first part 811, the bottom wall of the upper wall of second part 813 and the second groove 71
Distance prevent from teetertottering so that matrix is stuck between second part and the second groove not less than the thickness of matrix；Third is recessed
The width matching of the width and matrix of slot 81 enables connection electrode to enter precisely into if equal or the former is slightly larger than the latter
First groove.
In order to further increase fixed reliability, prevent up and down direction from shaking, a pair of of protrusion 43 is oppositely disposed at institute
The two sides of ontology 11 are stated, are adapted to passing through for electrode 61 between protrusion 43；The extension 12, a pair of of protrusion 43 and first are recessed
Slot 21 is set gradually；Distance between the upper wall of the second part 813 and 71 bottom wall of the second groove is not less than (preferably phase
Deng) the sum of the thickness of the ontology 12 and a pair of of protrusion 43.
It is shaken on left and right directions in order to prevent, further, the downside of the upper part has the first blocking portion, such as described
The side wall of second groove forms first blocking portion, described when the pair of protrusion moves in second groove
First blocking portion stops.
In order to further prevent shaking on left and right directions, the ontology 11 have the second blocking portion 42, the extension 12,
First groove 21 and the second blocking portion 42 are set gradually so that first blocking portion with the faces of a pair of of projection contacts to described
The distance between face of connection electrode contacted with the second blocking portion is equal to the face back to the second blocking portion of a pair of of protrusion to the
Distance of two blocking portions in face of the face of a pair of of protrusion；When the connection electrode 61 relatively moves in first groove 21,
Stopped by second blocking portion 42.
For the ease of pulling described matrix, further, one far from the discharge electrode 31 of the ontology 11
The side at end has protrusion 41, and the protrusion 41 and second groove 22 are in the same side of the ontology, convenient for using
Hand push draws protrusion 41.
Contact in connection electrode with discharge electrode for convenience, further, the electric discharge in first groove
The end 33 of electrode be it is spherical, the bottom of first groove 21 has recessed with the end the matched 5th of the discharge electrode
Slot, end 33 are completely in the first groove 21.
In order to avoid contact of the connection electrode with capillary in relative movement thereof, further, the discharge electrode
Central axis to the 4th groove bottom wall distance be not less than the extension radius.
The working method of the above-mentioned ion source of the embodiment of the present invention, the working method the following steps are included:
(A1) one end of capillary is immersed in sample solution, sample solution enters the end of capillary, but and capillary
Interior discharge electrode does not contact；
Matrix is caught in the first part of third groove of guide part,
(A2) finger presses protrusion, and pushes matrix mobile, and matrix slides onto slope, into second part；
Connection electrode passes through between a pair of of protrusion, and relatively moves in the 4th groove；
(A3) connection electrode enters in the first groove, contacts with the discharge electrode in the first groove；Described matrix (including one
To protrusion) it is stuck between the second part and the second groove, prevent the shaking of matrix in the up-down direction；
Meanwhile a pair of of protrusion is stopped by the side wall of the second groove, connection electrode 61 is stopped by the second blocking portion, it is therefore prevented that base
Body shakes in the lateral direction；
High direct voltage, discharge electrode electric discharge are accessed by connection electrode, the solution in capillary is ionized, and from capillary
Interior ejection, into mass spectral analysis；
When replacement, protrusion is pressed with hand, pulls out matrix, connection electrode and discharge electrode are detached from.
Embodiment 2:
Application examples of according to embodiments of the present invention 1 ion source in pulse direct current ion source.
In the application example, the length for stretching out the capillary of extension is 10mm-15mm, outer diameter 1mm-2mm, and internal diameter is
0.5mm-1.5mm；Stretch out the end of the discharge electrode of the extension to the end of the capillary for stretching out extension away from
From for 5mm-10mm, diameter 0.2mm-1mm；Along the capillary far from the direction of the ontology, capillary it is interior
Diameter becomes smaller, and the internal diameter of end is 10 μm -200 μm；The end of discharge electrode in the first groove be it is spherical, the 4th groove
Bottom has matched 5th groove in end with the discharge electrode；Protrusion is arc, and the second blocking portion is rectangle, is in
The same side of the ontology；The distance of bottom wall of the central axis of the discharge electrode to the 4th groove is prolonged not less than described
The radius of extending portion, that is, the bottom wall of the outer rim of extension and the 4th groove flushes, when preventing connection electrode and matrix from relatively moving
Contact capillary；Distance between the upper wall of second part and second groove bottom wall is equal to the thickness of the ontology and a pair of of protrusion
Degree the sum of, the first blocking portion between the face contacted with the second blocking portion in the face of a pair of of projection contacts to the connection electrode
Distance be equal to distance of the face back to the second blocking portion of a pair of of protrusion to the second blocking portion in face of the face of a pair of of protrusion.
Embodiment 3:
The ion source of the embodiment of the present invention 3, unlike the first embodiment:
The distance of no longer a pair of of protrusion of setting, the bottom wall of the upper wall of second part to the second groove is equal to the thickness of ontology.
Embodiment 4:
The ion source of the embodiment of the present invention 4, unlike the first embodiment:
4th groove is no longer set, the spy of the width matching (such as width is equal) of the width and matrix of third groove is utilized
Point when so that matrix moving in third groove, will not sway forwards and backwards, and connection electrode can enter precisely into the first groove.
Claims (10)
1. a kind of ion source, the ion source includes capillary and discharge electrode；It is characterized by: the ion source further include:
Matrix, described matrix have ontology and extension, insulate between the discharge electrode and matrix；One end of the capillary is solid
It is scheduled in the extension, the other end stretches out extension；The ontology has the first groove, and one end of the discharge electrode is exposed
In first groove, the other end is in the capillary；
Guide part, the guide part include upper and bottom section setting up and down；The downside of the upper part is recessed with second
Slot, connection electrode are arranged on the upper part and extend in the second groove；The lower part has and second groove
The third groove being oppositely arranged；The third groove includes the first part set gradually, slope and second part, and described second
Part is higher than first part；Distance between the upper wall of the second part and the third groove bottom wall is not less than the ontology
Thickness.
2. ion source according to claim 1, it is characterised in that: described matrix further include:
A pair of of protrusion, the pair of protrusion are oppositely disposed at the two sides of the ontology, and the logical of electrode is adapted between protrusion
It crosses；The extension, a pair of of protrusion and the first groove are set gradually；The upper wall of the second part and second groove bottom wall
Between distance not less than the ontology and a pair of of protrusion the sum of thickness.
3. ion source according to claim 2, it is characterised in that: the downside of the upper part has the first blocking portion, when
When the pair of protrusion moves in second groove, stopped by first blocking portion.
4. ion source according to claim 3, it is characterised in that: the side wall of second groove, which forms described first, to be stopped
Portion.
5. ion source according to claim 3, it is characterised in that: the ontology have the second blocking portion, the extension,
First groove and the second blocking portion are set gradually；It is described when the connection electrode relatively moves in first groove
Second blocking portion stops.
6. ion source according to claim 5, it is characterised in that: the face with a pair of of projection contacts of first blocking portion
The distance between face contacted with the second blocking portion to the connection electrode be equal to a pair of of protrusion back to the second blocking portion
Face is to the second blocking portion in face of the distance in the face of a pair of of protrusion.
7. application of -6 any ion sources in pulse direct current ion source according to claim 1.
8. the working method of -6 any ion sources according to claim 1, the working method the following steps are included:
(A1) first part being placed on described matrix in third groove；
(A2) described matrix is pushed, matrix slides onto slope, into second part；
Connection electrode and described matrix relatively move；
(A3) connection electrode enters in the first groove, contacts with the discharge electrode in the first groove；Described matrix is stuck in described
Between two parts and the second groove.
9. the working method of ion source according to claim 8, it is characterised in that: a pair of protrusion on matrix is with matrix
It is moved between second part and the second groove, connection electrode passes through between opposite a pair of the protrusion in position.
10. the working method of ion source according to claim 8, it is characterised in that: in step (A3), the second groove
Side wall stops the movement of a pair of of protrusion, and connection electrode is stopped by the second blocking portion on matrix；The side wall, connects a pair of of protrusion
Receiving electrode and the second blocking portion are arranged successively.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910626284.8A CN110233094A (en) | 2019-07-11 | 2019-07-11 | Ion source and its working method, application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910626284.8A CN110233094A (en) | 2019-07-11 | 2019-07-11 | Ion source and its working method, application |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110233094A true CN110233094A (en) | 2019-09-13 |
Family
ID=67855448
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910626284.8A Pending CN110233094A (en) | 2019-07-11 | 2019-07-11 | Ion source and its working method, application |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110233094A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112993637A (en) * | 2021-04-26 | 2021-06-18 | 宁波华仪宁创智能科技有限公司 | Gas-electricity integrated interface device, mass spectrum system and maintenance method |
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|---|---|---|---|---|
| US5965883A (en) * | 1997-08-25 | 1999-10-12 | California Institute Of Technology | Capillary for electrospray ion source |
| US20060049347A1 (en) * | 2004-09-03 | 2006-03-09 | Joyce Timothy H | Capillaries for mass spectrometry |
| CN201185172Y (en) * | 2006-12-29 | 2009-01-21 | 东华理工大学 | Surface desorption atmospheric chemical ionization source |
| CN206440663U (en) * | 2016-12-31 | 2017-08-25 | 宁波华仪宁创智能科技有限公司 | Mass spectrometry system with quantitative function |
| CN108428613A (en) * | 2017-12-31 | 2018-08-21 | 宁波大学 | Open type ion source and method |
| CN207868161U (en) * | 2018-01-26 | 2018-09-14 | 广州禾信仪器股份有限公司 | Open type ion source system and mass spectrograph |
| CN108572212A (en) * | 2017-03-08 | 2018-09-25 | 布鲁克道尔顿有限公司 | The manufacturing method and its operating method of ionic migration spectrometer, its main body |
| CN109716483A (en) * | 2016-09-21 | 2019-05-03 | 福满代谢组技术有限公司 | Ion source adapter |
| CN210092029U (en) * | 2019-07-11 | 2020-02-18 | 宁波大学 | Ion source |
-
2019
- 2019-07-11 CN CN201910626284.8A patent/CN110233094A/en active Pending
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5965883A (en) * | 1997-08-25 | 1999-10-12 | California Institute Of Technology | Capillary for electrospray ion source |
| US20060049347A1 (en) * | 2004-09-03 | 2006-03-09 | Joyce Timothy H | Capillaries for mass spectrometry |
| CN201185172Y (en) * | 2006-12-29 | 2009-01-21 | 东华理工大学 | Surface desorption atmospheric chemical ionization source |
| CN109716483A (en) * | 2016-09-21 | 2019-05-03 | 福满代谢组技术有限公司 | Ion source adapter |
| CN206440663U (en) * | 2016-12-31 | 2017-08-25 | 宁波华仪宁创智能科技有限公司 | Mass spectrometry system with quantitative function |
| CN108572212A (en) * | 2017-03-08 | 2018-09-25 | 布鲁克道尔顿有限公司 | The manufacturing method and its operating method of ionic migration spectrometer, its main body |
| CN108428613A (en) * | 2017-12-31 | 2018-08-21 | 宁波大学 | Open type ion source and method |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112993637A (en) * | 2021-04-26 | 2021-06-18 | 宁波华仪宁创智能科技有限公司 | Gas-electricity integrated interface device, mass spectrum system and maintenance method |
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