CN110227100A - A kind of topical agent for treating onychomycosis - Google Patents

A kind of topical agent for treating onychomycosis Download PDF

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Publication number
CN110227100A
CN110227100A CN201910702048.XA CN201910702048A CN110227100A CN 110227100 A CN110227100 A CN 110227100A CN 201910702048 A CN201910702048 A CN 201910702048A CN 110227100 A CN110227100 A CN 110227100A
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parts
lotion
cover
medical fluid
topical agent
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Chinese (zh)
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关彦芳
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Henan National Institute Of Craftsmanship And Podiatry Medicine
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Henan National Institute Of Craftsmanship And Podiatry Medicine
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Priority to CN201910702048.XA priority Critical patent/CN110227100A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/15—Pinaceae (Pine family), e.g. pine or cedar
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/489—Sophora, e.g. necklacepod or mamani
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/708—Rheum (rhubarb)
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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Abstract

The invention discloses a kind of topical agent for treating onychomycosis, ingredient and mass content that first lotion includes are as follows: 20~23.4 parts of glycerol, 14.5~18.9 parts of vaseline, 3.2~5.2 parts of Java brucea, 8.9~12.1 parts of salicylic acid；The ingredient and mass content that second lotion includes are as follows: 32.3~35.6 parts of glycerol, 14.5~16.7 parts of rheum officinale, 12.3~12.5 parts of kuh-seng, 3.4~6.5 parts of triethanolamine；The ingredient and mass content that the medical fluid includes are as follows: 28.5~31.2 parts of corter pseudolaricis, 26.7~28.9 parts of cortex dictamni, 21.7~24.3 parts of natrium adetate, pure appropriate amount of water.

Description

A kind of topical agent for treating onychomycosis
Technical field
The present invention relates to onychomycosis pharmaceutical techniques field, in particular to a kind of topical agent for treating onychomycosis.
Background technique
Onychomycosis is commonly called as " onychomycosis ", refers to that dermatophytes invades disease caused under deck or first.Onychomycosis is by skin The fungus-caused first infection such as tinea bacterium, saccharomycete and non-dermatophytes.First fungi common are two kinds: the 1. white first (superficial of fungoid Property white onychomycosis), this type of disease damage is confined to that first face is a piece of or its tip；2. nosomycosis divides distal side bit-type, close under first again First mo(u)ld bottom half and superficial white type are held, this type of lesion then infects under deck since the two sides of first or distal end.
In order to treat onychomycosis, technical solution commonly used in the prior art has following several:
Chinese patent application 201611015568.6 discloses a kind of drug for treating onychomycosis, its main feature is that component are as follows: Cortex acanthopanacis, big maple, thallus laminariae, cloves, fennel；Component ratio are as follows: each 10 grams of the above drug；Production method is: weighing according to quantity above-mentioned Medicament boils when bubble every time, and temperature properly, is then steeped again, 15-30 minutes each, three times a day.
A kind of Traditional chinese medicine medicament formula for treating onychomycosis of Chinese patent application 201611197351.1, its main feature is that component Are as follows: Golden Larch Bark, Cortex Phellodendri, kuh-seng, lopseed, arrow, single clove garlic, a light-coloured vinegar；Components by weight: 40 grams of Golden Larch Bark, 30 grams of Cortex Phellodendri, 20 grams, one 30 grams of arrow of lopseed, 20 grams of single clove garlic, 2000 milliliters of light-coloured vinegar；Make instructions of taking are as follows: above 5 kinds of medicinal materials are mixed, It along with 2000 milliliters of light-coloured vinegars, decocts and takes juice, as onychomycosis treats medical fluid.Sick first 15-30 minutes are impregnated every night, all medical fluids Access times are generally 15 times.
But the formula of onychomycosis treatment technology scheme in the prior art is not thorough the treatment of onychomycosis, is easy multiple Hair, and side effect is big.It is therefore proposed that a kind of topical agent for treating onychomycosis and its save set solve the above problems very It is necessary to.
Summary of the invention
(1) the technical issues of solving
In view of the deficiencies of the prior art, the present invention provides a kind of topical agents for treating onychomycosis, solve the prior art In technical solution the treatment of onychomycosis is not thorough, be easy recurrence, and the technical problem that side effect is big.
(2) technical solution
In order to achieve the above object, the present invention is achieved by the following technical programs:
A kind of topical agent for treating onychomycosis, including the first lotion, the second lotion and medical fluid；It is characterized by: described The ingredient and mass content that first lotion includes are as follows: 20~23.4 parts of glycerol, 14.5~18.9 parts of vaseline, Java brucea 3.2~ 5.2 parts, 8.9~12.1 parts of salicylic acid.
The ingredient and mass content that second lotion includes are as follows: 32.3~35.6 parts of glycerol, 14.5~16.7 parts of rheum officinale, 12.3~12.5 parts of kuh-seng, 3.4~6.5 parts of triethanolamine.
The ingredient and mass content that the medical fluid includes are as follows: 28.5~31.2 parts of corter pseudolaricis, 26.7~28.9 parts of cortex dictamni, 21.7~24.3 parts of natrium adetate, pure appropriate amount of water.
Optionally, first lotion further includes 26.5~31 parts of balsamine, 11.5~14.5 parts of basil oil, tristearin 2.2 parts~4.7 parts of acid.
Optionally, second lotion includes 24.5~26.7 parts of Rhizoma Chuanxiong, 5.6~7.8 parts of cinnamon oil.
It optionally, further include 17.8~22.4 parts of ketoconazole in the medical fluid.
It optionally, further include kuh-seng, salicylic acid, benzoic acid, boric acid in the medical fluid.
It optionally, further include talcum powder in the medical fluid.
Optionally, the corter pseudolaricis, cortex dictamni are made as dry powdered, and the specific surface area S of the powder is 750- 1150m2/g。
It optionally, further include kuh-seng, salicylic acid, benzoic acid, boric acid in the medical fluid.
It optionally, further include talcum powder in the medical fluid.
Optionally, the kuh-seng, salicylic acid, benzoic acid, boric acid mass fraction total in medical fluid are w1, the quality point Number w1 is preferably 4-6.5%.
Optionally, the specific surface area S and mass fraction w1 of the powder meet Sw1 and are less than or equal to more than or equal to 35 72.5。
Optionally, the topical agent of the treatment onychomycosis, is first applied to affected part for the first lotion, after time T1, The second lotion is applied to affected part again；It after time T2, is cleaned up with clear water through the lotion in affected part, is suffered from being impregnated with medical fluid Place；The soaking time of medical fluid is T3, later again cleans up medical fluid with clear water, affected part is dried or dried；This is primary Complete medication.
Optionally, above-mentioned primary complete medication, daily (24 hours) once, can be realized ash in continuous use 3-7 days and refer to First fully recovers.
Optionally, the time T1 is 10-25 minutes, and the time T2 is 10-25 minutes, and the time T3 is 20-30 Minute.
Optionally, first lotion is applied to the time T1 in affected part, the second lotion is applied to the time T2 in affected part, medical fluid impregnates The time T3 in affected part meets following relationship:
1≤(T1+T2)/T3≤1.4；
When less than 1, fungi can not be killed well, treat onychomycosis；If it is greater than 1.4, it is easy to cause affected part Skin is corroded, damages seriously, causes other germs to invade, is unfavorable for health.
Optionally, it in order to thoroughly cure onychomycosis, prevents from recurring, and avoid side effect, the mass fraction is w1, compares table Area S, the first lotion are applied to the time T1 in affected part, the second lotion is applied to the time T2 in affected part, the time T3 in medical fluid immersion affected part Between meet following relationship:
T1+ (T3/T2)=α w1S；
Wherein, α is adjustment factor, value range 0.53-0.82.
It is described the invention also discloses a kind of save set of topical agent for treating onychomycosis, including tank body and cover Cover is set to the top of tank body, and the bottom end of the tank body is connected with mobile base, leads at the lower surface of the mobile base It crosses connector and is rotatably connected to universal wheel, be equipped with knob in the middle part of the leading flank of the mobile base.In the upper surface of the cover Portion is equipped with handwheel, and the front and rear sides of the cover are respectively connected with locating piece, offer on the tank body and be adapted to the locating piece Locating slot.
Optionally, the top of rotation axis is connected in the middle part of the lower surface of the handwheel, cover is inserted into the bottom end of the rotation axis, The rotation axis is rotatablely connected by bearing and cover, and the bottom end of the rotation axis is connected with driving bevel gear, the active umbrella The two sides of gear engage and are connected with driven bevel pinion, and two driven bevel pinions are symmetrical arranged, two driven umbrella tooths It takes turns and is respectively connected with transmission shaft in the middle part of opposite one side, one end of the transmission shaft is connected with threaded rod.
Optionally, the threaded one end of the threaded rod is connected with screw shell, and one end of the screw shell is connected with solid Determine block；One end of the middle side part connection rotary shaft of the knob, the other end of the rotary shaft are inserted into mobile base, the rotation The both ends of shaft are rotatablely connected with the inner wall of mobile base, and the other end of the rotary shaft is fixedly connected with first gear, institute The bottom end engagement for stating first gear is connected with the second gear of perpendicular setting, and the second gear passes through bearing and mobile bottom The inner wall rotation connection of seat, the middle part of the second gear are equipped with screw rod, and the top of the screw rod is connected with limited block, the spiral shell The top of the bottom end connection support bar of bar, the bottom end of the support rod are pierced by mobile base and are connected with pressing disc, the pushing The lower surface of disk is connected with rubber pad.
Optionally, it is respectively connected with anti-rotation block in the middle part of the two sides of the screw shell, is offered on the inner wall of the cover The rotation stop groove being adapted to the anti-rotation block, the anti-rotation block are slidably connected with rotation stop groove.
Optionally, the fixing groove being adapted to the fixed block is offered on the inner wall of the tank body, the one of the fixed block End is set as inclined-plane, and one end of the fixed block is pierced by cover and protrudes into fixing groove.
Optionally, the lower surface of the cover circumferentially offers seal groove, and the seal groove is embedded with sealing ring, described close Seal is bonded with tank body.
Optionally, offer the thread groove being adapted to the screw rod in the middle part of the second gear, the second gear with Screw flight connection.
Optionally, one end of the limited block be equipped with gag lever post, the both ends of the gag lever post run through limited block and with shifting The inner wall connection of dynamic pedestal, the limited block are slidably connected with gag lever post.
Optionally, the width H of the seal groove is 1.5-3.8mm, and the section of the sealing ring is circle, diameter D For 1.8-4.3mm, and it is greater than with the diameter of the sealing ring of the seal groove cooperation width of seal groove.
Optionally, the material of the sealing ring is elastic material, preferably nitrile rubber, silicon rubber, fluorine silicone rubber, Buddhist nun One of dragon, polyformaldehyde.
Optionally, in order to guarantee sealing performance, the volatilization of lotion and medical fluid is prevented, the rebound degree K of the sealing ring is 60- 90%, tensile strength M are 14-35MPa；Preferably, KM is met between the rebound degree K, tensile strength M more than or equal to 12.5 Less than or equal to 30.2.
Optionally, in order to be adapted the sealing performance of save set and the performance of lotion and medical fluid, guarantee sealing performance, The specific surface area S of the powder, mass fraction w1, rebound degree K, meet following relationship between tensile strength M:
W1·S1/2=β (MK)；
Wherein, β is regulatory factor, value range 0.04-0.26.
(3) beneficial effect
Compared with prior art, the present invention provides a kind of topical agent for treating onychomycosis, have it is following the utility model has the advantages that
(1) topical agent for the treatment of onychomycosis of the invention, by the component for determining the first lotion, the second lotion, medical fluid And content, to improve the effect for the treatment of onychomycosis.
(2) topical agent for the treatment of onychomycosis of the invention, by the first lotion, the second lotion, medical fluid triple function, To further increase the effect for the treatment of onychomycosis.
(3) topical agent for the treatment of onychomycosis of the invention passes through setting corter pseudolaricis, the state of cortex dictamni and powder The relationship of the range and kuh-seng of specific surface area S, salicylic acid, benzoic acid, boric acid mass fraction total in medical fluid, preferably to kill Fungus killing treats onychomycosis.
(4) topical agent for the treatment of onychomycosis of the invention is w1, specific surface area S, the first cream by setting mass fraction The pass that body is applied to the time T1 in affected part, the second lotion is applied to the time T2 in affected part, meets between the time T3 in medical fluid immersion affected part System, thoroughly to cure onychomycosis, prevents from recurring, and avoid side effect.
Detailed description of the invention
Fig. 1 is topical agent constituent content figure of the invention.
Fig. 2 is the save set schematic diagram of topical agent of the invention.
Fig. 3 is the save set top view of topical agent of the invention.
Fig. 4 is the save set diagrammatic cross-section of topical agent of the invention.
Fig. 5 is the enlarged diagram of the portion A structure in Fig. 4 of the present invention.
Fig. 6 is the side elevational cross-section schematic diagram of mobile base structure of the present invention.
In figure: 1, tank body；2, mobile base；3, universal wheel；4, knob；5, cover；6, handwheel；7, locating piece；8, it positions Slot；9, rotation axis；10, driving bevel gear；11, driven bevel pinion；12, transmission shaft；13, threaded rod；14, screw shell；15, only Switch block；16, rotation stop groove；17, fixed block；18, fixing groove；19, seal groove；20, sealing ring；21, rotary shaft；22, first gear； 23, second gear；24, screw rod；25, limited block；26, gag lever post；27, support rod；28, pressing disc；29, rubber pad.
Specific embodiment
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete Site preparation description, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.It is based on Embodiment in the present invention, it is obtained by those of ordinary skill in the art without making creative efforts every other Embodiment shall fall within the protection scope of the present invention.
In the description of the present invention, it is to be understood that, term " center ", " longitudinal direction ", " transverse direction ", " length ", " width ", " thickness ", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom" "inner", "outside", " up time The orientation or positional relationship of the instructions such as needle ", " counterclockwise ", " axial direction ", " radial direction ", " circumferential direction " be orientation based on the figure or Positional relationship is merely for convenience of description of the present invention and simplification of the description, rather than the device or element of indication or suggestion meaning must There must be specific orientation, be constructed and operated in a specific orientation, therefore be not considered as limiting the invention.
In the present invention unless specifically defined or limited otherwise, term " setting ", " installation ", " connected ", " connection ", Terms such as " fixations " shall be understood in a broad sense, for example, it may be being fixedly connected, may be a detachable connection；It can be mechanical connect It connects；It can be directly connected, it can also be indirectly connected through an intermediary.For the ordinary skill in the art, may be used To understand the concrete meaning of above-mentioned term in the present invention as the case may be.
In addition, term " first ", " second " etc. are used for description purposes only, it is not understood to indicate or imply relatively important Property or implicitly indicate the quantity of indicated technical characteristic.Define " first " as a result, the feature of " second " can be expressed or Person implicitly includes one or more of the features.
Embodiment 1
As shown in Figure 1, a kind of topical agent for treating onychomycosis, including the first lotion, the second lotion and medical fluid；Described The ingredient and mass content that one lotion includes are as follows: 20~23.4 parts of glycerol, 14.5~18.9 parts of vaseline, Java brucea 3.2~5.2 Part, 8.9~12.1 parts of salicylic acid.The ingredient and mass content that second lotion includes are as follows: 32.3~35.6 parts of glycerol, rheum officinale 14.5~16.7 parts, 12.3~12.5 parts of kuh-seng, 3.4~6.5 parts of triethanolamine.The ingredient and mass content that the medical fluid includes Are as follows: 28.5~31.2 parts of corter pseudolaricis, 26.7~28.9 parts of cortex dictamni, 21.7~24.3 parts of natrium adetate, pure appropriate amount of water.
The corter pseudolaricis, cortex dictamni are made as dry powdered, and the specific surface area S of the powder is 750-1150m2/g。
The topical agent of the treatment onychomycosis, is first applied to affected part for the first lotion, after time T1, then by second Lotion is applied to affected part；It after time T2, is cleaned up with clear water through the lotion in affected part, is impregnating affected part with medical fluid；Medical fluid Soaking time is T3, is later again cleaned up medical fluid with clear water, and affected part is dried or dried；This is primary complete use Medicine.
Above-mentioned primary complete medication, once, the complete of onychomycosis can be realized in continuous use 3-7 days in daily (24 hours) Rehabilitation.
The time T1 is 10-25 minutes, and the time T2 is 10-25 minutes, and the time T3 is 20-30 minutes.Institute State the first lotion is applied to the time T1 in affected part, the second lotion is applied to the time T2 in affected part, medical fluid impregnate affected part time T3 meet Following relationship:
1≤(T1+T2)/T3≤1.4；
When less than 1, fungi can not be killed well, treat onychomycosis；If it is greater than 1.4, it is easy to cause affected part Skin is corroded, damages seriously, causes other germs to invade, is unfavorable for health.
The present invention provides a kind of save sets of topical agent for treating onychomycosis as shown in figures 2-6, including tank body 1 With cover 5；Shown cover 5 is set to the top of tank body 1, and the bottom end of tank body 1 is fixedly connected with mobile base 2, mobile base 2 Lower surface four corners pass through connector and are rotatably connected to universal wheel 3, convenient for being moved to tank body 1, the front side of mobile base 2 Middle face is equipped with knob 4.
The upper surface middle part of shown cover 5 is equipped with handwheel 6, and the front and rear sides of cover 5 are fixedly connected to locating piece 7, tank The locating slot 8 being adapted to locating piece 7 is offered on body 1, convenient for the installation of cover 5.
The top of rotation axis 9 is fixedly connected in the middle part of the lower surface of shown handwheel 6, the bottom end of rotation axis 9 is inserted into cover 5, is turned Moving axis 9 is rotatablely connected by bearing and cover 5, and the bottom end of rotation axis 9 is fixedly connected with driving bevel gear 10, driving bevel gear 10 Two sides engage and be connected with driven bevel pinion 11, two driven bevel pinions 11 are symmetrical arranged, and two driven bevel pinions 11 are opposite One side in the middle part of be fixedly connected to transmission shaft 12, one end of transmission shaft 12 is fixedly connected with threaded rod 13.
The threaded one end of shown threaded rod 13 is connected with screw shell 14, and transmission is convenient, in the two sides of screw shell 14 Portion is fixedly connected to anti-rotation block 15, offers the rotation stop groove 16 being adapted to anti-rotation block 15 on the inner wall of cover 5, anti-rotation block 15 with Rotation stop groove 16 is slidably connected, and facilitates screw shell 14 to carry out linear movement, one end of screw shell 14 is fixedly connected with fixed block 17, the fixing groove 18 being adapted to fixed block 17 is offered on the inner wall of tank body 1, and one end of fixed block 17 is set as inclined-plane, can Cover 5 and tank body 1 are completely embedded, one end of fixed block 17 is pierced by cover 5 and protrudes into fixing groove 18, the lower surface week of cover 5 To seal groove 19 is offered, seal groove 19 is embedded with sealing ring 20, and sealing ring 20 is bonded with tank body 1, enhances leakproofness.
One middle side part of shown knob 4 is fixedly connected with one end of rotary shaft 21, and the other end of rotary shaft 21 is inserted into mobile bottom Seat 2, the both ends of rotary shaft 21 are rotatablely connected with the inner wall of mobile base 2, and the other end of rotary shaft 21 is fixedly connected with first Gear 22, the bottom end engagement of first gear 22 are connected with the second gear 23 of perpendicular setting, and second gear 23 passes through bearing Be rotatablely connected with the inner wall of mobile base 2, the middle part of second gear 23 is equipped with screw rod 24, the middle part of second gear 23 offer with The thread groove that screw rod 24 is adapted to, second gear 23 are threadedly coupled with screw rod 24, and transmission is convenient, and the top of screw rod 24 is fixedly connected with Limited block 25, one end of limited block 25 are equipped with gag lever post 26, the both ends of gag lever post 26 run through limited block 25 and with mobile base 2 Inner wall be fixedly connected, limited block 25 is slidably connected with gag lever post 26, can the position mobile to screw rod 24 be defined, screw rod 24 bottom end is fixedly connected with the top of support rod 27, and the bottom end of support rod 27 is pierced by mobile base 2 and is fixedly connected with pressing disc 28, the lower surface of pressing disc 28 is fixedly connected with rubber pad 29.
Working principle:
It is when covering cover 5, locating piece 7 is corresponding with locating slot 8, convenient for the fixation of cover 5, rotate handwheel 6, handwheel 6 Rotation axis 9 is driven to rotate, rotation axis 9 drives driving bevel gear 10 to rotate, and driving bevel gear 10 drives two driven bevel pinions 11 Rotation, driven bevel pinion 11 drive threaded rod 13 to rotate by transmission shaft 12, and threaded rod 13 drives screw shell 14 to carry out linearly Mobile, screw shell 14 drives anti-rotation block 15 to slide in rotation stop groove 16, and screw shell 14 drives fixed block 17 to be moved to fixation In slot 18, cover 5 and tank body 1 are closely linked together, good airproof performance, when needing to move tank body 1, rotation rotation Button 4, knob 4 drive rotary shaft 21 to rotate, and rotary shaft 21 drives first gear 22 to rotate, and first gear 22 drives second gear 23 Rotation, second gear 23 drive screw rod 24 to carry out linear movement, and screw rod 24 drives limited block 25 to slide on gag lever post 26, screw rod 24 drive support rods 27 move up, support rod 27 by pressing disc 28 drive rubber pad 29 move up, make rubber pad 29 to Upper movement can move tank body 1 after rubber pad 29 is detached from ground.In use, being deposited respectively using three save sets Put the first lotion, the second lotion and medical fluid.
Embodiment 2
A kind of topical agent for treating onychomycosis, including the first lotion, the second lotion and medical fluid；First lotion includes Ingredient and mass content are as follows: 20~23.4 parts of glycerol, 14.5~18.9 parts of vaseline, 3.2~5.2 parts of Java brucea, salicylic acid 8.9~12.1 parts, 26.5~31 parts of balsamine, 11.5~14.5 parts of basil oil, 2.2 parts~4.7 parts of stearic acid.Described The ingredient and mass content that two lotions include are as follows: 32.3~35.6 parts of glycerol, 14.5~16.7 parts of rheum officinale, kuh-seng 12.3~12.5 Part, 3.4~6.5 parts of triethanolamine, 24.5~26.7 parts of Rhizoma Chuanxiong, 5.6~7.8 parts of cinnamon oil.
The ingredient and mass content that the medical fluid includes are as follows: 28.5~31.2 parts of corter pseudolaricis, 26.7~28.9 parts of cortex dictamni, It is 21.7~24.3 parts of natrium adetate, 17.8~22.4 parts of ketoconazole, kuh-seng, salicylic acid, benzoic acid, boric acid, talcum powder, pure Appropriate amount of water.The kuh-seng, salicylic acid, benzoic acid, boric acid, the content of talcum powder are very clear in the prior art, no longer It repeats herein.
The corter pseudolaricis, cortex dictamni are made as dry powdered, and the specific surface area S of the powder is 750-1150m2/g。
The kuh-seng, salicylic acid, benzoic acid, boric acid mass fraction total in medical fluid are w1, and the mass fraction W1 is excellent It is selected as 4-6.5%.
The specific surface area S and mass fraction w1 of the powder meet Sw1 and are less than or equal to 72.5 more than or equal to 35.
The topical agent of the treatment onychomycosis, is first applied to affected part for the first lotion, after time T1, then by second Lotion is applied to affected part；It after time T2, is cleaned up with clear water through the lotion in affected part, is impregnating affected part with medical fluid；Medical fluid Soaking time is T3, is later again cleaned up medical fluid with clear water, and affected part is dried or dried；This is primary complete use Medicine.
Above-mentioned primary complete medication, once, the complete of onychomycosis can be realized in continuous use 3-7 days in daily (24 hours) Rehabilitation.
The time T1 is 10-25 minutes, and the time T2 is 10-25 minutes, and the time T3 is 20-30 minutes.Institute State the first lotion is applied to the time T1 in affected part, the second lotion is applied to the time T2 in affected part, medical fluid impregnate affected part time T3 meet Following relationship:
1≤(T1+T2)/T3≤1.4；
When less than 1, fungi can not be killed well, treat onychomycosis；If it is greater than 1.4, it is easy to cause affected part Skin is corroded, damages seriously, causes other germs to invade, is unfavorable for health.
In order to thoroughly cure onychomycosis, prevent from recurring, and avoid side effect, the mass fraction is w1, specific surface area S, First lotion is applied to the time T1 in affected part, the second lotion is applied to the time T2 in affected part, medical fluid impregnates between the time T3 in affected part completely It is enough lower relationship:
T1+ (T3/T2)=α w1S；
Wherein, α is adjustment factor, value range 0.53-0.82.
A kind of save set of topical agent that treating onychomycosis, including tank body 1 and cover 5；Shown cover 5 is set to tank The top of body 1, the bottom end of tank body 1 are fixedly connected with mobile base 2, and the lower surface four corners of mobile base 2 pass through connector It is rotatably connected to universal wheel 3, convenient for moving to tank body 1, knob 4 is equipped in the middle part of the leading flank of mobile base 2.
The upper surface middle part of shown cover 5 is equipped with handwheel 6, and the front and rear sides of cover 5 are fixedly connected to locating piece 7, tank The locating slot 8 being adapted to locating piece 7 is offered on body 1, convenient for the installation of cover 5.
The top of rotation axis 9 is fixedly connected in the middle part of the lower surface of shown handwheel 6, the bottom end of rotation axis 9 is inserted into cover 5, is turned Moving axis 9 is rotatablely connected by bearing and cover 5, and the bottom end of rotation axis 9 is fixedly connected with driving bevel gear 10, driving bevel gear 10 Two sides engage and be connected with driven bevel pinion 11, two driven bevel pinions 11 are symmetrical arranged, and two driven bevel pinions 11 are opposite One side in the middle part of be fixedly connected to transmission shaft 12, one end of transmission shaft 12 is fixedly connected with threaded rod 13.
The threaded one end of shown threaded rod 13 is connected with screw shell 14, and transmission is convenient, in the two sides of screw shell 14 Portion is fixedly connected to anti-rotation block 15, offers the rotation stop groove 16 being adapted to anti-rotation block 15 on the inner wall of cover 5, anti-rotation block 15 with Rotation stop groove 16 is slidably connected, and facilitates screw shell 14 to carry out linear movement, one end of screw shell 14 is fixedly connected with fixed block 17, the fixing groove 18 being adapted to fixed block 17 is offered on the inner wall of tank body 1, and one end of fixed block 17 is set as inclined-plane, can Cover 5 and tank body 1 are completely embedded, one end of fixed block 17 is pierced by cover 5 and protrudes into fixing groove 18, the lower surface week of cover 5 To seal groove 19 is offered, seal groove 19 is embedded with sealing ring 20, and sealing ring 20 is bonded with tank body 1, enhances leakproofness.
One middle side part of shown knob 4 is fixedly connected with one end of rotary shaft 21, and the other end of rotary shaft 21 is inserted into mobile bottom Seat 2, the both ends of rotary shaft 21 are rotatablely connected with the inner wall of mobile base 2, and the other end of rotary shaft 21 is fixedly connected with first Gear 22, the bottom end engagement of first gear 22 are connected with the second gear 23 of perpendicular setting, and second gear 23 passes through bearing Be rotatablely connected with the inner wall of mobile base 2, the middle part of second gear 23 is equipped with screw rod 24, the middle part of second gear 23 offer with The thread groove that screw rod 24 is adapted to, second gear 23 are threadedly coupled with screw rod 24, and transmission is convenient, and the top of screw rod 24 is fixedly connected with Limited block 25, one end of limited block 25 are equipped with gag lever post 26, the both ends of gag lever post 26 run through limited block 25 and with mobile base 2 Inner wall be fixedly connected, limited block 25 is slidably connected with gag lever post 26, can the position mobile to screw rod 24 be defined, screw rod 24 bottom end is fixedly connected with the top of support rod 27, and the bottom end of support rod 27 is pierced by mobile base 2 and is fixedly connected with pressing disc 28, the lower surface of pressing disc 28 is fixedly connected with rubber pad 29.
The width H of the seal groove is 1.5-3.8mm, and the section of the sealing ring is circle, and diameter D is 1.8- 4.3mm, and the width with the diameter of the sealing ring of seal groove cooperation greater than seal groove.
The material of the sealing ring is elastic material, preferably nitrile rubber, silicon rubber, fluorine silicone rubber, nylon, polyformaldehyde One of.
In order to guarantee sealing performance, the volatilization of lotion and medical fluid is prevented, the rebound degree K of the sealing ring is 60-90%, is drawn Stretching intensity M is 14-35MPa；Preferably, meet between the rebound degree K, tensile strength M KM more than or equal to 12.5 be less than etc. In 30.2.
In order to be adapted the sealing performance of save set and the performance of lotion and medical fluid, guarantee sealing performance, the powder The specific surface area S at end, mass fraction w1, rebound degree K, meet following relationship between tensile strength M:
W1·S1/2=β (MK)；
Wherein, β is regulatory factor, value range 0.04-0.26.
It should be noted that in the present invention unless specifically defined or limited otherwise, fisrt feature is in second feature It can be that the first and second features directly contact or the first and second features are by intermediary mediate contact "up" or "down". Moreover, fisrt feature can be above the second feature " above ", " above " and " above " fisrt feature right above second feature or tiltedly Top, or first feature horizontal height is merely representative of higher than second feature.Fisrt feature second feature " under ", " lower section " and " following " can be fisrt feature and be directly under or diagonally below the second feature, or be merely representative of first feature horizontal height less than Two features.
Finally, it should be noted that the foregoing is only a preferred embodiment of the present invention, it is not intended to restrict the invention, Although the present invention is described in detail referring to the foregoing embodiments, for those skilled in the art, still may be used To modify the technical solutions described in the foregoing embodiments or equivalent replacement of some of the technical features, All within the spirits and principles of the present invention, any modification, equivalent replacement, improvement and so on should be included in of the invention Within protection scope.

Claims (7)

1. a kind of topical agent for treating onychomycosis, including the first lotion, the second lotion and medical fluid；It is characterized by: described The ingredient and mass content that one lotion includes are as follows: 20~23.4 parts of glycerol, 14.5~18.9 parts of vaseline, Java brucea 3.2~ 5.2 parts, 8.9~12.1 parts of salicylic acid；
The ingredient and mass content that second lotion includes are as follows: 32.3~35.6 parts of glycerol, 14.5~16.7 parts of rheum officinale, kuh-seng 12.3~12.5 parts, 3.4~6.5 parts of triethanolamine；
The ingredient and mass content that the medical fluid includes are as follows: 28.5~31.2 parts of corter pseudolaricis, 26.7~28.9 parts of cortex dictamni, according to ground 21.7~24.3 parts of acid disodium, pure appropriate amount of water.
2. a kind of topical agent for treating onychomycosis according to claim 1, it is characterised in that: first lotion also wraps Include 26.5~31 parts of balsamine, 11.5~14.5 parts of basil oil, 2.2 parts~4.7 parts of stearic acid.
3. a kind of topical agent for treating onychomycosis according to claim 1 or 2, it is characterised in that: second lotion Including 24.5~26.7 parts of Rhizoma Chuanxiong, 5.6~7.8 parts of cinnamon oil.
4. a kind of topical agent for treating onychomycosis according to claim 1-3, it is characterised in that: the medical fluid In further include 17.8~22.4 parts of ketoconazole.
5. a kind of topical agent for treating onychomycosis according to claim 1-3, it is characterised in that: the medical fluid In further include kuh-seng, salicylic acid, benzoic acid, boric acid.
6. a kind of topical agent for treating onychomycosis according to claim 1-3, it is characterised in that: the medical fluid In further include talcum powder.
7. a kind of save set of the topical agent for the treatment of onychomycosis according to claim 1-6, feature exist In: including tank body and cover, the cover is set to the top of tank body, and the bottom end of the tank body is connected with mobile base, described Pass through connector at the lower surface of mobile base and be rotatably connected to universal wheel, is equipped with rotation in the middle part of the leading flank of the mobile base Button；The upper surface middle part of the cover is equipped with handwheel, and the front and rear sides of the cover are respectively connected with locating piece, open on the tank body Equipped with the locating slot being adapted to the locating piece；The top of connection rotation axis, the rotation axis in the middle part of the lower surface of the handwheel Bottom end be inserted into cover, the rotation axis is rotatablely connected by bearing and cover, and the bottom end of the rotation axis is connected with active umbrella Gear, the two sides of the driving bevel gear engage and are connected with driven bevel pinion, and two driven bevel pinions are symmetrical arranged, and two It is respectively connected with transmission shaft in the middle part of the opposite one side of a driven bevel pinion, one end of the transmission shaft is connected with threaded rod.
CN201910702048.XA 2019-07-31 2019-07-31 A kind of topical agent for treating onychomycosis Pending CN110227100A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110876756A (en) * 2019-12-17 2020-03-13 罗香英 Ointment for treating onychomycosis

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CN1686301A (en) * 2005-04-18 2005-10-26 汪世龙 Erternal used medicament used for treating ashen nail
CN106728747A (en) * 2016-12-22 2017-05-31 杜翔宇 A kind of Traditional chinese medicine medicament formula for treating onychomycosis
CN107519236A (en) * 2017-09-12 2017-12-29 安徽世龙生物医药科技有限公司 A kind of topical agent for treating onychomycosis
CN108066414A (en) * 2016-11-18 2018-05-25 江倩倩 A kind of drug for treating onychomycosis
CN108714162A (en) * 2018-07-19 2018-10-30 张笑笑 A kind of external used medicine for treating onychomycosis
CN109999535A (en) * 2019-04-25 2019-07-12 桐城市红豆杉生态农林科技有限公司 A kind of Chinese yew extracts the leaching device of taxol

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Publication number Priority date Publication date Assignee Title
CN1686301A (en) * 2005-04-18 2005-10-26 汪世龙 Erternal used medicament used for treating ashen nail
CN108066414A (en) * 2016-11-18 2018-05-25 江倩倩 A kind of drug for treating onychomycosis
CN106728747A (en) * 2016-12-22 2017-05-31 杜翔宇 A kind of Traditional chinese medicine medicament formula for treating onychomycosis
CN107519236A (en) * 2017-09-12 2017-12-29 安徽世龙生物医药科技有限公司 A kind of topical agent for treating onychomycosis
CN108714162A (en) * 2018-07-19 2018-10-30 张笑笑 A kind of external used medicine for treating onychomycosis
CN109999535A (en) * 2019-04-25 2019-07-12 桐城市红豆杉生态农林科技有限公司 A kind of Chinese yew extracts the leaching device of taxol

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110876756A (en) * 2019-12-17 2020-03-13 罗香英 Ointment for treating onychomycosis

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