CN110215502A - Chinese medicine composition of antibacterial anti-inflammatory and preparation method thereof, application - Google Patents

Chinese medicine composition of antibacterial anti-inflammatory and preparation method thereof, application Download PDF

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CN110215502A
CN110215502A CN201910629458.6A CN201910629458A CN110215502A CN 110215502 A CN110215502 A CN 110215502A CN 201910629458 A CN201910629458 A CN 201910629458A CN 110215502 A CN110215502 A CN 110215502A
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chinese medicine
medicine composition
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沈敬国
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Guangzhou Baijia Moxibustion Biotechnology Co Ltd
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Guangzhou Baijia Moxibustion Biotechnology Co Ltd
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Abstract

The present invention relates to Chinese medicine compositions of a kind of antibacterial anti-inflammatory and preparation method thereof, application.The Chinese medicine composition is prepared from raw materials including the following parts by weight: stem 80-120 parts of 20-40 parts of folium artemisiae argyi, 10-30 parts of lycopodium calvatum, 10-30 parts of lopseed, 10-30 parts of berba aristolochiae mollissimae, 5-20 parts of uncaria, 5-20 parts of radix scutellariae, 5-15 parts of kuh-seng, 5-15 parts of Cortex Phellodendri, 5-15 parts of honeysuckle, 5-15 parts of Sargent gloryvine, 5-20 parts of smilax, 5-20 parts of Semen Cuscutae, 5-20 parts of Herba Epimedii, 5-20 parts of fructus alpiniae oxyphyllae, 5-15 parts of the vine of multiflower knotweed, 5-15 parts of semen ziziphi spinosae, 5-15 parts of cortex albiziae, 5-15 parts of lemongrass and Chinese mugwort.Chinese medicine composition of the invention has good antibacterial and anti-inflammatory effects for gynaecological imflammation.

Description

Chinese medicine composition of antibacterial anti-inflammatory and preparation method thereof, application
Technical field
The present invention relates to field of medicaments more particularly to a kind of Chinese medicine composition of antibacterial anti-inflammatory and preparation method thereof, application.
Background technique
Medicinal bath therapy refers to by making effective ingredient by transdermal with containing Chinese medicine liquid bathing whole body or part A kind of method absorbed, belongs to one of external therapy.Medicinal bath therapy is divided into dipping bath and stifling bath, and dipping bath is divided into " whole body according to position Dipping bath "；The title for having " scalding ", " smoked to wash ", " hip bath ", " lavipeditum " etc. again of local bathing.Skin is the maximum organ of human body, is removed Have outside the protective effect for resisting exopathogen invasion, also the multiple functions such as secretion, absorption, infiltration, excretion, feeling.
" Chinese Pharmacopoeia " 2015 editions records, folium artemisiae argyi warming channel for arresting bleeding, eliminating cold to stop pain；External application removing dampness to stop itchin.Pruitus is controlled outside. It is one of Chinese medicine foot bath therapy that folium artemisiae argyi, which steeps foot, but it is only used only folium artemisiae argyi single pulvis, and drug effect is single and slow effect, is applicable in more In health care, it is difficult to be effectively prevented to disease.
Summary of the invention
Based on this, an object of the present invention is to provide a kind of Chinese medicine composition of antibacterial anti-inflammatory, for vaginitis, skin The private parts subhealth symptom such as skin itch, all has good therapeutic effect.
Specific technical solution is as follows:
A kind of Chinese medicine composition of antibacterial anti-inflammatory, is prepared from raw materials including the following parts by weight:
20-40 parts of folium artemisiae argyi, 10-30 parts of lycopodium calvatum, 10-30 parts of lopseed, 10-30 parts of berba aristolochiae mollissimae, 5-20 parts of uncaria, radix scutellariae 5-20 parts, 5-15 parts of kuh-seng, 5-15 parts of Cortex Phellodendri, 5-15 parts of honeysuckle, 5-15 parts of Sargent gloryvine, 5-20 parts of smilax, Semen Cuscutae 5-20 Part, 5-20 parts of Herba Epimedii, 5-20 parts of fructus alpiniae oxyphyllae, 5-15 parts of the vine of multiflower knotweed, 5-15 parts of semen ziziphi spinosae, 5-15 parts of cortex albiziae, lemongrass 5-15 Stem 80-120 parts of part and Chinese mugwort.
The effect of above-mentioned each component and meridian distribution of property and flavor are as follows:
Folium artemisiae argyi is recorded in 2015 editions " Chinese Pharmacopoeias ", pungent, bitter, temperature；Liver,spleen,kidney is returned to pass through.Warming channel for arresting bleeding, eliminating cold to stop pain； External application removing dampness to stop itchin.For spitting blood, bleeding from five sense organs or subcutaneous tissue, metrorrhagia and metrostaxis, menorrhalgia, blood under vaginal bleeding during pregnancy, abdomen crymodynia are uncomfortable through trembling with fear, uterus cold infertile； Pruitus is controlled outside.Vinegar Chinese mugwort charcoal warming channel for arresting bleeding, is used for deficient cold type bleeding.
Lycopodium calvatum is recorded in 2015 editions " Chinese Pharmacopoeias ", slight bitter, acrid in flavour and warm in nature.Liver,spleen,kidney is returned to pass through.Dispelling wind and eliminating dampness, relaxing muscles and tendons are living Network.For joint pain, joint stuffiness.
Lopseed is recorded in Compendium of Material Medica, dispelling wind and eliminating dampness, relaxing tendons and activating collaterals.
Uncaria is recorded in 2015 editions " Chinese Pharmacopoeias ", sweet, cool.Return liver, pericardium channel.Dispelling wind and relieving convulsion, The flat liver of heat-clearing.For Liver wind agitation, twitch, hyperpyretic convulsion, dysphoric cold, children's crying with fear, pre-eclampsia, headache and dizziness.
Radix scutellariae is recorded in 2015 editions " Chinese Pharmacopoeias ", bitter, is trembled with fear.Return lung, gallbladder, spleen, large intestine, small intestinl channel；Heat-clearing and damp-drying drug is rushed down Fire removing toxic substances, hemostasis, miscarriage prevention.For damp-warm syndrome, summer-heat and damp, chest tightness and emesis, damp and hot feeling of fullness, dysentery, jaundice, cough with lung heat, hyperpyrexia polydipsia, Blood-head tells nosebleed, carbuncle sore tumefacting virus, threatened abortion.
Kuh-seng is recorded in 2015 editions " Chinese Pharmacopoeias ", bitter, is trembled with fear.Return heart, liver, stomach, large intestine, bladder meridian.Heat-clearing and damp-drying drug is killed Worm, diuresis.
Cortex Phellodendri is recorded in 2015 editions " Chinese Pharmacopoeias ", bitter, trembles with fear.Return kidney, bladder meridian.Heat-clearing and damp-drying drug, purging intense heat, except steaming, removing toxic substances Treat sore.For damp-heat dysentery, yellow subcutaneous ulcer urinates red, leukorrhagia pruritus vulvae, puckery pain of heat gonorrhea, tinea pedis Wei cu, hectic fever due to yin labor heat, night sweat, spermatorrhea, sore Pyogenic infections, eczema wet sore.
Honeysuckle is recorded in 2015 editions " Chinese Pharmacopoeias ", sweet, trembles with fear.Return lung, the heart, stomach meridian.It is clearing heat and detoxicating, dispelling wind and heat from the body.With In carbuncle swells furunculosis, sore throat, erysipelas, toxic-heat and blood stasis, wind-heat cold, warm disease and fever.
Sargent gloryvine, alias sargentodoxa cuneata, it records in 2015 editions " Chinese Pharmacopoeias ", it is bitter, it puts down.Return large intestine, Liver Channel.Cheongju thermal detoxification, it is living Blood, wind-expelling pain-stopping.For abdominalgia with intestinal abscess, pathopyretic ulcer, menostasis, dysmenorrhea, tumbling and swelling, rheumatic arthralgia.
Smilax is recorded in 2015 editions " Chinese Pharmacopoeias ", sweet, light, is put down.Return liver, stomach meridian.Removing toxic substances, dehumidifying is easing joint movement. For limbs muscular constricture, arthralgia and myalgia caused by syphilis and mercury poisoning；Damp and hot stranguria with turbid discharge, leukorrhagia, carbuncle swells, scrofula, scabies.
Semen Cuscutae is recorded in 2015 editions " Chinese Pharmacopoeias ", pungent, sweet and neutral.Liver,kidney,spleen is returned to pass through.It tonifies the liver and kidney, controlling nocturnal emission with astringent drugs contracting Urine, miscarriage prevention, improving eyesight, antidiarrheal；External application disappears wind nti-freckle.For kidney deficiency and liver, soreness and weakness of waist and knees, impotence and seminal emission, enuresis frequent micturition, kidney deficiency tire Leakage, threatened abortion, blurred vision tinnitus, spleen kidney deficiency are rushed down；Externally treating leucoderma.
Herba Epimedii is recorded in 2015 editions " Chinese Pharmacopoeias ", acrid, sweet, warm.Return liver and kidney channel.Kidney-replenishing, strengthening the bones and muscles, wind-dispelling It is wet.For decline of kidney-YANG, impotence and seminal emission, muscles and bones impotence, rheumatic arthralgia, numbness contracture.
Fructus alpiniae oxyphyllae is recorded in 2015 editions " Chinese Pharmacopoeias ", acrid in flavour and warm in nature.Returns spleen, kidney channel warm up kidney astringent sperm contracting urine, warming spleen and stopping diarrha to take the photograph Saliva.For enuresis with renal asthenia, frequent urination, gonorrhoea of passing out semen, malaria diarrhea, crymodynia in abdomen, the more salivas of mouth.
The vine of multiflower knotweed is recorded in 2015 editions " Chinese Pharmacopoeias ", sweet and neutral.Converge to heart and liver channels.Nourishing blood and tranquilization, dispelling wind and removing obstruction in the meridians.For Insomnia and dreamful sleep, deficiency of blood bodily pain, rheumatic arthralgia, pruitus.
Semen ziziphi spinosae is recorded in 2015 editions " Chinese Pharmacopoeias ", sweet, sour, is put down.Return liver, gallbladder, the heart channel of Hang-Shaoyin.Nourishing heart tonifying liver, calming heart peace Mind, arrest sweating promote the production of body fluid.For restlessness of asrhenia type and insomnia, horrified to much dream, body void hidrosis, injury thirst.
Cortex albiziae is recorded in 2015 editions " Chinese Pharmacopoeias ", sweet and neutral.Return heart, liver, lung channel.Resolving stagnation for tranquilization, activating blood circulation and reducing swelling.With In confused and worried, melancholy insomnia, pulmonary abscess, sore swells, the pain of injury caused by falling and tumbling.
Lemongrass is recorded in " China's book on Chinese herbal medicine ", pungent；Temperature；It is sweet.Dispelling wind and removing obstruction in the meridians, warm in pain, antidiarrheal.
It is a further object of the present invention to provide a kind of preparation methods of Chinese medicine composition, comprising the following steps:
(1) folium artemisiae argyi, lycopodium calvatum, lopseed, berba aristolochiae mollissimae, uncaria, radix scutellariae, kuh-seng, Cortex Phellodendri, gold and silver are weighed by the parts by weight Flower, Sargent gloryvine, smilax, Semen Cuscutae, Herba Epimedii, fructus alpiniae oxyphyllae, the vine of multiflower knotweed, semen ziziphi spinosae, cortex albiziae and lemongrass；
(2) medicinal material of step (1) is extracted with Extraction solvent, obtains extracting solution；
(3) Chinese mugwort stem is weighed by the parts by weight, is crushed, obtained Chinese mugwort stem powder is mixed with the extracting solution of step (2).
Based on the above-mentioned technical proposal, the invention has the following advantages:
Symptom ownership based on gynaecological imflammation is mostly dirty related with liver, kidney two, and the present invention goes out from removing dampness to stop itchin, heat-clearing and damp-drying drug Hair, it is antipruritic to be equipped with desinsection, tonifies the liver and kidney.By adding lycopodium calvatum, lopseed, berba aristolochiae mollissimae, uncaria, radix scutellariae, kuh-seng, Cortex Phellodendri, gold Honeysuckle flower, Sargent gloryvine, smilax, Semen Cuscutae, Herba Epimedii, fructus alpiniae oxyphyllae, the vine of multiflower knotweed, semen ziziphi spinosae, cortex albiziae, lemongrass and wormwood, Ai Jingjin Row dialectical compatibility has obtained the Chinese medicine composition with good antibacterial and anti-inflammatory effects, for yin such as vaginitis, pruituses Portion's subhealth symptom, all has good therapeutic effect.
In theory of traditional Chinese medical science, gynaecological imflammation is damp invasion of lower energizer, qi depression to blood stasis causes, for this symptom.Fang Zhong, folium artemisiae argyi, Chinese mugwort The strong Yuanyang of stem, smilax, relaxing tendons and activating collaterals, removing dampness to stop itchin are monarch drug in a prescription；It is lycopodium calvatum, lopseed, berba aristolochiae mollissimae, uncaria, lemongrass, red Rattan cooperation is ministerial drug with dispelling wind and eliminating dampness, activating microcirculation and removing stasis medicinal；Kuh-seng, radix scutellariae, honeysuckle, Cortex Phellodendri, which are matched, closes antibacterial anti-inflammatory, heat-clearing and damp-drying drug The benefits of, it is adjutant；Semen Cuscutae, Herba Epimedii, fructus alpiniae oxyphyllae, the vine of multiflower knotweed, cortex albiziae, semen ziziphi spinosae, which are combined with, fills up kidney channel, nourishing liver and kidney The effect of, promote liver heat row's note, to make medicine；Entirely can dispelling wind and eliminating dampness, promoting flow of qi by warming channel, Yiyang kidney tonifying, antipyretic and itching-stopping, for gynaecology Inflammation has good curative effect.
Specific embodiment
To facilitate the understanding of the present invention, it below with reference to embodiment to invention is more fully described, is given below Presently preferred embodiments of the present invention.But the invention can be realized in many different forms, however it is not limited to described herein Embodiment.Purpose of providing these embodiments is makes the disclosure of the present invention more thorough and comprehensive.
Unless otherwise defined, all technical and scientific terms used herein and belong to technical field of the invention The normally understood meaning of technical staff is identical.Used term is intended merely to describe specific reality in the description of the invention Apply the purpose of example, it is not intended that in the limitation present invention.Term as used herein "and/or" includes one or more relevant institutes Any and all combinations of list of items.
The present invention provides a kind of Chinese medicine composition of antibacterial anti-inflammatory, is prepared from raw materials including the following parts by weight:
20-40 parts of folium artemisiae argyi, 10-30 parts of lycopodium calvatum, 10-30 parts of lopseed, 10-30 parts of berba aristolochiae mollissimae, 5-20 parts of uncaria, radix scutellariae 5-20 parts, 5-15 parts of kuh-seng, 5-15 parts of Cortex Phellodendri, 5-15 parts of honeysuckle, 5-15 parts of Sargent gloryvine, 5-20 parts of smilax, Semen Cuscutae 5-20 Part, 5-20 parts of Herba Epimedii, 5-20 parts of fructus alpiniae oxyphyllae, 5-15 parts of the vine of multiflower knotweed, 5-15 parts of semen ziziphi spinosae, 5-15 parts of cortex albiziae, lemongrass 5-15 Stem 80-120 parts of part and Chinese mugwort.
Preferably, the Chinese medicine composition is prepared from raw materials including the following parts by weight: 25-35 parts of folium artemisiae argyi stretches muscle 10-20 parts careless, 10-20 parts of lopseed, 10-20 parts of berba aristolochiae mollissimae, 8-18 parts of uncaria, 8-18 parts of radix scutellariae, 8-15 parts of kuh-seng, Cortex Phellodendri 8- 15 parts, 8-15 parts of honeysuckle, 8-15 parts of Sargent gloryvine, 8-18 parts of smilax, 8-18 parts of Semen Cuscutae, 8-18 parts of Herba Epimedii, fructus alpiniae oxyphyllae 8- Stem 90-110 parts of 18 parts, 8-15 parts of the vine of multiflower knotweed, 8-15 parts of semen ziziphi spinosae, 8-15 parts of cortex albiziae, 8-15 parts of lemongrass and Chinese mugwort.
Preferably, the Chinese medicine composition is prepared from raw materials including the following parts by weight: 28-32 parts of folium artemisiae argyi stretches muscle 12-18 parts careless, 12-18 parts of lopseed, 12-18 parts of berba aristolochiae mollissimae, 10-15 parts of uncaria, 10-15 parts of radix scutellariae, 8-12 parts of kuh-seng, Cortex Phellodendri 8-12 parts, 8-12 parts of honeysuckle, 8-12 parts of Sargent gloryvine, 10-15 parts of smilax, 10-15 parts of Semen Cuscutae, 10-15 parts of Herba Epimedii, intelligence development Stem 95-105 parts of 10-15 parts of benevolence, 8-12 parts of the vine of multiflower knotweed, 8-12 parts of semen ziziphi spinosae, 8-12 parts of cortex albiziae, 8-12 parts of lemongrass and Chinese mugwort.
Preferably, the Chinese medicine composition is prepared from raw materials including the following parts by weight: 30 parts of folium artemisiae argyi, lycopodium calvatum 15 Part, 15 parts of lopseed, 15 parts of berba aristolochiae mollissimae, 12 parts of uncaria, 12 parts of radix scutellariae, 10 parts of kuh-seng, 10 parts of Cortex Phellodendri, 10 parts of honeysuckle, Sargent gloryvine 10 parts, 12 parts of smilax, 12 parts of Semen Cuscutae, 12 parts of Herba Epimedii, 12 parts of fructus alpiniae oxyphyllae, 10 parts of the vine of multiflower knotweed, 10 parts of semen ziziphi spinosae, cortex albiziae 100 parts of stem of 10 parts, 10 parts of lemongrass and Chinese mugwort.
A kind of preparation method of Chinese medicine composition, comprising the following steps:
(1) folium artemisiae argyi, lycopodium calvatum, lopseed, berba aristolochiae mollissimae, uncaria, radix scutellariae, kuh-seng, Cortex Phellodendri, gold and silver are weighed by the parts by weight Flower, Sargent gloryvine, smilax, Semen Cuscutae, Herba Epimedii, fructus alpiniae oxyphyllae, the vine of multiflower knotweed, semen ziziphi spinosae, cortex albiziae and lemongrass；
(2) medicinal material of step (1) is extracted with Extraction solvent, obtains extracting solution；
(3) Chinese mugwort stem is weighed by the parts by weight, is crushed, obtained Chinese mugwort stem powder is mixed with the extracting solution of step (2).
In wherein some embodiments, the extracting solution is 1.12-1.15 in 90 DEG C of relative density.
In wherein some embodiments, the extracting solution is 1.13-1.14 in 90 DEG C of relative density.
Specifically, the Extraction solvent is water.The mode of the extraction is heating extraction.The heating extraction is to decoct to mention It takes.
In wherein some embodiments, the mesh number of the Chinese mugwort stem powder is greater than 100 mesh.Preferably, the mesh number of the Chinese mugwort stem powder For 100-120 mesh.
The present invention also provides a kind of application of above-mentioned Chinese medicine composition in the drug of preparation treatment gynecological disease.Specifically Ground, the gynecological disease are vaginitis.
Chinese medicine composition of the invention, can be by the collective effect of medicine and water, and using the effectively happy pore of temperature, drug is logical It crosses human skin and enters microcirculation, through hole key, acupuncture points on the human body enter defeated time whole body of channels and collaterals and play its drug effect, compared with conventional external application Preparation can preferably have the function that health care and disease prevention.
The content of present invention is further described below in conjunction with specific embodiment.
Embodiment 1
(1) weigh folium artemisiae argyi 30g, lycopodium calvatum 15g, lopseed 15g, berba aristolochiae mollissimae 15g, uncaria 12g, radix scutellariae 12g, kuh-seng 10g, Cortex Phellodendri 10g, honeysuckle 10g, Sargent gloryvine 10g, smilax 12g, Semen Cuscutae 12g, Herba Epimedii 12g, fructus alpiniae oxyphyllae 12g, vine of multiflower knotweed 10g, Semen ziziphi spinosae 10g, cortex albiziae 10g, lemongrass 10g, the above raw material is mixed.
(2) raw material of step (1) 3L water is decocted, decoction to medical fluid is 1.13-1.14, mistake in 90 DEG C of relative density Filter, obtains extracting solution.
(3) 100g Chinese mugwort stem is crushed to 110 mesh, obtained Chinese mugwort stem powder is mixed with the extracting solution of step (2), must be suspended Liquid dispenses 500ml/ bottles, and sterile purification processing, sterilizing, which is used, irradiates the processing of 25-50KGy dosage.
Embodiment 2
(1) folium artemisiae argyi 35g, lycopodium calvatum 20g, lopseed 10g, berba aristolochiae mollissimae 10g, uncaria 8g, radix scutellariae 8g, kuh-seng 8g, Huang are weighed Cypress 8g, honeysuckle 8g, Sargent gloryvine 8g, smilax 18g, Semen Cuscutae 18g, Herba Epimedii 8g, fructus alpiniae oxyphyllae 18g, vine of multiflower knotweed 8g, semen ziziphi spinosae 8g, cortex albiziae 15g, lemongrass 8g, the above raw material is mixed.
(2) raw material of step (1) 3L water is decocted, until medical fluid is 1.13-1.14 in 90 DEG C of relative density, is filtered, Obtain extracting solution.
(3) 90g Chinese mugwort stem is crushed to 110 mesh, obtained Chinese mugwort stem powder is mixed with the extracting solution of step (2), obtains suspension, 500ml/ bottles of packing, sterile purification processing, sterilizing irradiation 25-50KGy dosage processing.
Embodiment 3
(1) weigh folium artemisiae argyi 20g, lycopodium calvatum 25g, lopseed 25g, berba aristolochiae mollissimae 10g, uncaria 20g, radix scutellariae 20g, kuh-seng 5g, Cortex Phellodendri 5g, honeysuckle 5g, Sargent gloryvine 15g, smilax 20g, Semen Cuscutae 18g, Herba Epimedii 8g, fructus alpiniae oxyphyllae 18g, vine of multiflower knotweed 8g, wild jujube Benevolence 8g, cortex albiziae 5g, lemongrass 5g, above-mentioned raw materials are mixed.
(2) raw material of step (1) 2L water is decocted, until medical fluid is 1.13-1.14 in 90 DEG C of relative density, is filtered, Obtain extracting solution.
(3) 120g Chinese mugwort stem is crushed to 110 mesh, obtained Chinese mugwort stem powder is mixed with the extracting solution of step (2), must be suspended Liquid dispenses 500ml/ bottles, and sterile purification processing, sterilizing is handled with 25-50KGy irradiation dose.
One, bacteriostatic test
Experimental method: test strain be staphylococcus aureus (the 6th generation of ATCC6538), Escherichia coli (8099 the 6th generation), Candida albicans (the 6th generation of ATCC10231)；It is provided by China Committee for Culture Collection of Microorganisms's common micro-organisms center. Test specimen: the filtrate after medical filtration prepared by embodiment 1；It is diluted with water 20 times, 50 times, 100 times, 110 times.With test organisms Strain contact 3min.The measurement of sterilizing rate is referring to " disinfection technology standard " (version in 2002).
The results are shown in Table 1:
Table 1
As shown in Table 1, Chinese medicine composition of the invention is to staphylococcus aureus, Escherichia coli, Candida albicans Bacterium all has apparent fungistatic effect.
Two, effect test:
(1) 30 subjects research object: are chosen.It has the private parts subhealth symptom such as pudendal pruritus, vaginitis, treatment Antibiotic is not used in first 2 months, without serious hepatic renal dysfunction and tumour medical history.Age is 30-45 years old, average age 35 ± 5 years old, average course of disease 7 ± 3 weeks.The general information such as gender, age, course of disease of subject no significant difference (P > 0.05)；
(2) diagnostic criteria:
1. Western medicine diagnostic criteria
1.1 symptoms: external cause itch, cusalgia, or with the urethral stimulants symptom such as frequent micturition, urgent urination, urodynia, or with local thorn Swash symptom.
1.2 gynecologial examinations: uterine neck and vagina mucosa are congested, and secretion is abnormal；Trichomonas vaginitis secretion is steeped in yellow Foam shape；Colpomycosis secretion is in bean dregs sample；Senile vahinitis secretion is purulence sample or yellow water sample.
1.3 laboratories check: trichomonas vaginitis can find trichomonad in vaginal fluid under microscope；Mycotic yin Road inflammation can find mould in secretion.Vagina cleanness degree is at 1 ° or more.
(3) standards of grading:
The above iterated integral is severe in the 16-20 person of dividing；The 11-15 person of dividing is moderate；The 5-10 person of dividing is slight.
(4) treatment method: the Chinese medicine composition 500mL prepared using the embodiment of the present invention 1 uses about 50L warm water (water temperature 42 DEG C or so of control, 5 DEG C of positive negative error) after dilution this product, people, which enters in bathtub, to be impregnated 20 minutes.Once a day, it sleeps previous small When impregnate.1 the course for the treatment of 28 days, continue the 1-2 course for the treatment of.
(5) curative effect judges:
Cure: vagina, itching of vulva pain disappears, vaginal fluid inspection switchs to normally.Integral is 0 point.It is discontinued 3 menstruation weeks Phase checks normal without recurrence, items；
Effective: vaginal fluid checks that normally vagina, itching of vulva pain are substantially reduced, mitigate.Compare pre-treatment score after treatment Reduce by 2/3rds or more；
Effective: vaginal fluid inspection is normal and other symptoms still remain or other symptoms disappear, mitigates and vagina point Secretion checks abnormal.Than 1/3rd or more pre-treatment score decline after treatment；
It is invalid: before inspection and symptom are treated together after treatment；
(6) test result:
Treatment group: 17, effective 7, effective 3, invalid 3 are cured.Effective percentage is 90%.
Specific clinical case:
Plum schoolgirl, 43 years old, gynecologic patient, on November 28th, 2016, patient was because " pruritus of vagina increases January with secretion, adds It weighs 3 days." be admitted to hospital.Present illness history: increased with secretion before patient readme January without occurring pruritus of vagina under obvious inducement, because of thing in family Object is busy, goes to a doctor not in time, and conscious aggravation, vaginal fluid increase before 3 days, is in purulent secretion.Electronics is done in outpatient service Vaginoscopy is shown: two degree of erosions of uterine neck.Outpatient service is hospitalized with " 1. vaginitis, 2. cervical erosion " income.It is smart during patient Mind, sleep are good, and diet is general, is hard and dry, and urine is normal.Past medical history: the past body is strong, without various acute and chronic infectious disease diseases History.Non-diabetic and hypertension history.Without blood transfusion history, no food drug allergy history.History of preventive inoculation is unknown.Personal history: birth In local, no epidemic-stricken area contact history denies chemicals, poisonous substance and radiation contacts history, no smoking, excessive drinking bad habit.Menstruation History and martial history: usually menstruation is regular, and 14It gets married for 19 years old, and husband's body is strong, G3F31 youngster, 2 female is given birth to, body is strong.Family History: without family's hereditary disease and infectious disease medical history.
Gynecologial examination: vulva: development is normal, and pubes are distributed in women；Vagina: being shown in that vagina is smooth, there is a large amount of purulent secretions； Uterine neck: uterine neck is placed in the middle, and cervical erosion accounts for two degree of uterine neck in pure.Uterus: normal size, activity can, tenderness (-), no knock-on Bitterly；Double accessory: bilateral attachment area is shown no obvious abnormalities.
Auxiliary examination: electrocardiogram: sinus rhythm, T wave are abnormal (aVF, V2, V3, V4).Electronic colposcope inspection: see vagina Interior a large amount of purulent secretions, cervical erosion account for two degree of uterine neck in pure, it is proposed that row Leep physiotherapy after anti-inflammatory.Color ultrasound: double Kidney, double ureter, uterus, attachment no abnormality seen acoustic image.Bladder anuria, it is proposed that checked after suppressing urine.Vaginal fluid inspection: discovery Trichomonad coexists with mould, and III ° of cleannes, WBC+++/HP, pyocyte +++/HP.
Diagnosis: vaginitis.
The Chinese medicine composition 500mL prepared using the embodiment of the present invention 1, using about 50L warm water, (water temperature controls 42 DEG C of left sides The right side, 5 DEG C of positive negative error) after dilution this product, people, which enters in bathtub, to be impregnated 20 minutes.Once a day, previous hour is slept to impregnate.1 The course for the treatment of 28 days, continue 1 course for the treatment of.Vagina, itching of vulva pain disappears, vaginal fluid inspection switchs to normally；It is discontinued 3 menstrual cycles Without recurrence, items check normal.
Each technical characteristic of embodiment described above can be combined arbitrarily, for simplicity of description, not to above-mentioned reality It applies all possible combination of each technical characteristic in example to be all described, as long as however, the combination of these technical characteristics is not deposited In contradiction, all should be considered as described in this specification.
The embodiments described above only express several embodiments of the present invention, and the description thereof is more specific and detailed, but simultaneously It cannot therefore be construed as limiting the scope of the patent.It should be pointed out that coming for those of ordinary skill in the art It says, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to protection of the invention Range.Therefore, the scope of protection of the patent of the invention shall be subject to the appended claims.

Claims (10)

1. a kind of Chinese medicine composition of antibacterial anti-inflammatory, which is characterized in that it is prepared from raw materials including the following parts by weight:
20-40 parts of folium artemisiae argyi, 10-30 parts of lycopodium calvatum, 10-30 parts of lopseed, 10-30 parts of berba aristolochiae mollissimae, 5-20 parts of uncaria, radix scutellariae 5-20 It is part, 5-15 parts of kuh-seng, 5-15 parts of Cortex Phellodendri, 5-15 parts of honeysuckle, 5-15 parts of Sargent gloryvine, 5-20 parts of smilax, 5-20 parts of Semen Cuscutae, excessive 5-20 parts of the sheep leaves of pulse plants, 5-20 parts of fructus alpiniae oxyphyllae, 5-15 parts of the vine of multiflower knotweed, 5-15 parts of semen ziziphi spinosae, 5-15 parts of cortex albiziae, 5-15 parts of lemongrass and Chinese mugwort 80-120 parts of stem.
2. Chinese medicine composition according to claim 1, which is characterized in that its by include following parts by weight raw material preparation and At:
25-35 parts of folium artemisiae argyi, 10-20 parts of lycopodium calvatum, 10-20 parts of lopseed, 10-20 parts of berba aristolochiae mollissimae, 8-18 parts of uncaria, radix scutellariae 8-18 It is part, 8-15 parts of kuh-seng, 8-15 parts of Cortex Phellodendri, 8-15 parts of honeysuckle, 8-15 parts of Sargent gloryvine, 8-18 parts of smilax, 8-18 parts of Semen Cuscutae, excessive 8-18 parts of the sheep leaves of pulse plants, 8-18 parts of fructus alpiniae oxyphyllae, 8-15 parts of the vine of multiflower knotweed, 8-15 parts of semen ziziphi spinosae, 8-15 parts of cortex albiziae, 8-15 parts of lemongrass and Chinese mugwort 90-110 parts of stem.
3. Chinese medicine composition according to claim 2, which is characterized in that its by include following parts by weight raw material preparation and At:
28-32 parts of folium artemisiae argyi, 12-18 parts of lycopodium calvatum, 12-18 parts of lopseed, 12-18 parts of berba aristolochiae mollissimae, 10-15 parts of uncaria, radix scutellariae 10- 15 parts, 8-12 parts of kuh-seng, 8-12 parts of Cortex Phellodendri, 8-12 parts of honeysuckle, 8-12 parts of Sargent gloryvine, 10-15 parts of smilax, Semen Cuscutae 10-15 Part, 10-15 parts of Herba Epimedii, 10-15 parts of fructus alpiniae oxyphyllae, 8-12 parts of the vine of multiflower knotweed, 8-12 parts of semen ziziphi spinosae, 8-12 parts of cortex albiziae, lemongrass 8- 12 parts and stem 95-105 parts of Chinese mugwort.
4. Chinese medicine composition according to claim 3, which is characterized in that its by include following parts by weight raw material preparation and At:
30 parts of folium artemisiae argyi, 15 parts of lycopodium calvatum, 15 parts of lopseed, 15 parts of berba aristolochiae mollissimae, 12 parts of uncaria, 12 parts of radix scutellariae, 10 parts of kuh-seng, Cortex Phellodendri 10 parts, 10 parts of honeysuckle, 10 parts of Sargent gloryvine, 12 parts of smilax, 12 parts of Semen Cuscutae, 12 parts of Herba Epimedii, 12 parts of fructus alpiniae oxyphyllae, the vine of multiflower knotweed 10 100 parts of stem of part, 10 parts of semen ziziphi spinosae, 10 parts of cortex albiziae, 10 parts of lemongrass and Chinese mugwort.
5. a kind of preparation method of any one of claim 1-4 Chinese medicine composition, which comprises the following steps:
(1) by the parts by weight weigh folium artemisiae argyi, lycopodium calvatum, lopseed, berba aristolochiae mollissimae, uncaria, radix scutellariae, kuh-seng, Cortex Phellodendri, honeysuckle, Sargent gloryvine, smilax, Semen Cuscutae, Herba Epimedii, fructus alpiniae oxyphyllae, the vine of multiflower knotweed, semen ziziphi spinosae, cortex albiziae and lemongrass；
(2) medicinal material of step (1) is extracted with Extraction solvent, obtains extracting solution；
(3) Chinese mugwort stem is weighed by the parts by weight, is crushed, obtained Chinese mugwort stem powder is mixed with the extracting solution of step (2).
6. preparation method according to claim 5, which is characterized in that the extracting solution is in 90 DEG C of relative density 1.12-1.15。
7. preparation method according to claim 5, which is characterized in that in step (2), the Extraction solvent is water；With/ Or, the mode of the extraction is heating extraction；And/or the medicinal raw material total weight of the weight of the Extraction solvent and step (1) The ratio between are as follows: 10-15:1.
8. according to the described in any item preparation methods of claim 5-7, which is characterized in that the mesh number of the Chinese mugwort stem powder is 100- 120 mesh.
9. a kind of application of described in any item Chinese medicine compositions of claim 1-4 in the drug of preparation treatment gynecological disease.
10. application according to claim 9, the gynecological disease is vaginitis.
CN201910629458.6A 2019-07-12 2019-07-12 Chinese medicine composition of antibacterial anti-inflammatory and preparation method thereof, application Pending CN110215502A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105998949A (en) * 2016-05-11 2016-10-12 何旭东 Traditional Chinese medicine composition for treating skin disease and venereal disease
CN109010670A (en) * 2018-08-16 2018-12-18 陈怀银 A kind of drug and preparation method thereof for treating pruritus vulvue

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105998949A (en) * 2016-05-11 2016-10-12 何旭东 Traditional Chinese medicine composition for treating skin disease and venereal disease
CN109010670A (en) * 2018-08-16 2018-12-18 陈怀银 A kind of drug and preparation method thereof for treating pruritus vulvue

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