CN110215465A - A kind of leech processes formula and technique - Google Patents
A kind of leech processes formula and technique Download PDFInfo
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- CN110215465A CN110215465A CN201910683894.1A CN201910683894A CN110215465A CN 110215465 A CN110215465 A CN 110215465A CN 201910683894 A CN201910683894 A CN 201910683894A CN 110215465 A CN110215465 A CN 110215465A
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- 229940006607 hirudin Drugs 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
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- DNJIEGIFACGWOD-UHFFFAOYSA-N ethanethiol Chemical compound CCS DNJIEGIFACGWOD-UHFFFAOYSA-N 0.000 description 1
- 238000009313 farming Methods 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/62—Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
It processes and is formulated the invention discloses a kind of leech, the component including following parts by weight: 100 parts of leech, 20-60 parts of ginger rice vinegar juice；The ginger rice vinegar juice is mixed using ginger juice and rice vinegar by the weight ratio of 1:1.S1, the pretreatment of raw material: leech, ginger juice and rice vinegar are weighed up in proportion, and ginger juice and rice vinegar are mixed and made into ginger rice vinegar juice by the weight ratio of 1:1, pick the impurity in leech, spare；S2, the bored profit leech of ginger rice vinegar juice: leech being uniformly mixed with ginger rice vinegar juice, room temperature bored profit 5-7 hours, was during which stirred 1 time every 0.5-1.5 hours, so that it is evenly distributed, the leech after obtaining bored profit is spare；Leech after bored profit is dried and is crushed by S3: after the leech small fire fried dry after bored profit, it is placed in baking oven, it is 5-7 hours dry through 50-70 DEG C, and it is dry to water content 10-20% hereinafter, crushing is fine powder.Leech of the present invention uses the bored profit of ginger rice vinegar juice room temperature, ironed without high temperature, can be reduced drug ingedient loss, drug effect is avoided to reduce.
Description
Technical field
Present invention relates particularly to a kind of leech to process formula and technique.
Background technique
Leech at home and abroad has quite long history for curing the disease.In China, leech is first recorded in " legendary god of farming's book on Chinese herbal medicine
Through ", calling it can break " accumulation of blood lump in the abdomen ", with continually developing for the medicinal range of leech, on tcm clinical practice " by extravesated blood, extravasated blood "
Common single or compatibility compound preparation, especially prevent the Chinese patent drug of cardiovascular and cerebrovascular disease from gradually increasing, such as thrombolysis capsule, promoting blood circulation
Pulse invigorating capsule is injected bitterly by stasis of blood Huoxue Capsule, glad multiple Kang Rong capsule, thrombosis, Tongxinluo, brain blood health, logical, the thin blood of promoting blood circulation
Liquid, Maixuekang, antithrombotic piece etc., and great function has been played to epidemiology is improved.Tcm internal medicine is also by the worm after drying
The brewed patent medicine of body, the diseases such as treatment stasis of blood block, blood stasis, amenorrhoea, traumatic injury.
Hirudin is main effective medicinal ingredient of leech, is a kind of single chain polypeptide containing 65 amino acid residues, point
Son amount is 7000 or so, aminoterminal disulfide bond containing there are three, can be in conjunction with the catalytic site of fibrin ferment；63 casein amino acids
Sulphation improves the binding ability of hirudin and fibrin ferment.Leech is salty, bitter, puts down；It is slightly poisonous.There is blood-breaking promoting menstruation, by stagnation resolvation disease
The effect of.Therefore it is used for blood stasis , abdominal mass and lump, hemiplegia, injury from falling down.
It is undoubtedly unsuitable directly medicinal because the tough hardly possible of leech is broken, smell is stench.Clinic has running water leech to suck affected part hemostasis, takes orally
Then because leech has special bad smell and is not easy the characteristic crushed, and there is certain toxicity, even if in the ironed method of tradition
It processes, fishy smell is also difficult to remove, enter in decoction, and some patients detest in swallowing, or have different degrees of digestive tract reaction.
Since leech is a kind of significant curative effect ground precious Chinese medicine, at present for leech demand cumulative year after year, leech
It propagates artificially or less, the existing ironed loss of effective components that will cause leech of concocting method high temperature causes leech resource tight
It lacks.
Summary of the invention
The purpose of the present invention is to overcome the shortcomings of the existing technology, provides a kind of leech and processes formula and technique, to solve
The problem of existing concocting method high temperature ironed loss of effective components that will cause leech.
To achieve the above object, the technical solution used in the present invention is:
On the one hand, a kind of leech processing formula is provided, the component including following parts by weight:
100 parts of leech, 20-60 parts of ginger rice vinegar juice；The ginger rice vinegar juice presses the weight of 1:1 using ginger juice and rice vinegar
Part ratio is mixed.
Preferably, including the component of following parts by weight:
100 parts of leech, 40 parts of ginger rice vinegar juice；The ginger rice vinegar juice presses the parts by weight of 1:1 using ginger juice and rice vinegar
Ratio is mixed.
Preferably, the leech selects States Pharmacopoeia specifications Hirudinidae animal leech, and coloury drying uniform in size is complete
Body.
Preferably, the ginger juice is the juice cleaned using fresh ginger rhizome, squeezed after peeling.
Preferably, the rice vinegar uses the rice vinegar of States Pharmacopoeia specifications.
On the other hand, a kind of leech processing procedure is provided, is included the following steps,
S1, the pretreatment of raw material: leech, ginger juice and rice vinegar are weighed up in proportion, and ginger juice and rice vinegar press the weight of 1:1
Amount part ratio is mixed and made into ginger rice vinegar juice, picks the impurity in leech, spare；
The bored profit leech of ginger rice vinegar juice: S2 leech is uniformly mixed with ginger rice vinegar juice, room temperature bored profit 5-7 hours, during which
It was stirred 1 time every 0.5-1.5 hours, so that it is evenly distributed, the leech after obtaining bored profit is spare；
Leech after bored profit is dried and is crushed by S3: after the leech small fire fried dry after bored profit, being placed in baking oven, through 50-
70 DEG C 5-7 hours dry, dry to water content 10-20% hereinafter, crushing is fine powder.
Preferably, being uniformly mixed leech with ginger rice vinegar juice in the step S2, the bored profit of room temperature 6 hours is during which every
It was stirred 1 time every 1 hour, so that it is evenly distributed, the leech after obtaining bored profit is spare.
Preferably, being placed in baking oven in the step S3 by after the leech small fire fried dry after bored profit, through 60 DEG C dry 6
Hour, it is dry to water content 15% hereinafter, crushing is fine powder.
The major function of various medicinal materials used by inventive formulation is as follows:
Leech: nature and flavor are salty, bitter, flat, toxic.The major functions: postpartum anemic fainting (blood knot in the heart, or relatively abdomen less, or it is connected in the side of body
Rib), traumatic injury (distinguishes blood stagnation, trusted subordinate's distending pain, sphincter disturbance), and pendant falls internal injury, and red white poison is swollen.
Ginger: nature and flavor are pungent, tepor, nontoxic.The major functions: malaria fever and chills (the poly- phlegm of taste, send out as fever and chills), feverish cough of trembling with fear, cholera
It has a cramp, enter abdomen and be intended to extremely, painful chest and hypochondrium pain (under ambition, the side of body, hard pain turgor), constipation, hygropyretic jaundice, profusely rotten sore, tooth pain
Bitterly, middle poisoning of drug, injury by sword or axe, dodge handy foot, traumatic injury, oxter body odour, red leucoderma, two anricular frostbites, and all poison anal fistula is not tied long
Scab.
Rice vinegar: the bitter temperature of nature and flavor dissipates the stasis of blood and removes disease, holds back qi and blood subduing inflammation, and damages stomach.It helps digestion the major functions: (making wine) dissipates stasis of blood removing toxic substances,
Rice vinegar (specially enters liver), this dampness and heat forms, and taste is then bitter, temperature, and acid master holds back, therefore book heavy duty dissipates stasis of blood removing toxic substances, helps digestion；And with wood
Perfume mill clothes, then control all pains of trusted subordinate's vim and vigour；Enter nose with fire vinegar of quenching, then controls postpartum anemic fainting；And close surgery drug application, then crux phlegm addiction is controlled,
Subcutaneous ulcer Huang carbuncle swells and mouth are coughed to control tongue boil, and face, which is coated with, dissipates damage hematocele, and kills all poison of flesh of fish dish gill fungus.
The invention has the benefit that
1. leech of the present invention uses the bored profit of ginger rice vinegar juice room temperature, ironed without high temperature, drug ingedient loss can be reduced,
Drug effect is avoided to reduce；Promote the dissolution of leech effective component by the tender taste of ginger rice, rice vinegar juice, be convenient for absorption of human body after fine powder,
The clinical efficacy of leech is improved, therefore drug effect can be been significantly enhanced；Leech is through ginger juice and the bored profit of rice vinegar juice, then small fire
After fried dry, drying keeps drug frangible, improves drug fishy odor, enhances curative effect of medication, weakens toxicity；Leech is logical with blood-breaking
Through by stagnation resolvation disease and other effects, ginger juice and rice vinegar juice have the effects that synergy removing toxic substances, rectify smelly flavoring, with ginger juice and rice vinegar juice
Leech is made, can play the role of mutual reinforcement between mutually makes, and cooperates with and proves effective；
After addition processes leech using ginger juice, the bored profit of rice vinegar juice, the physical weight of leech medicinal material product can increase, simultaneously
Complete reservation and human body because of effective ingredient preferably absorb, and under same dose, leech actual use amount is accordingly reduced, thus
Under the premise of not reducing clinical drug effect, the dosage of leech medicinal material can be reduced, there is very big meaning to protection leech resource.
Specific embodiment
To make the object, technical solutions and advantages of the present invention clearer, below in conjunction with the specific embodiment of the invention pair
Technical solution of the present invention is clearly and completely described.
Embodiment 1,
A kind of leech processing formula, the component including following parts by weight:
100 parts of leech, 20 parts of ginger rice vinegar juice；The ginger rice vinegar juice presses the parts by weight of 1:1 using ginger juice and rice vinegar
Ratio is mixed.
The leech selects States Pharmacopoeia specifications Hirudinidae animal leech, and uniform in size coloury dry all.
The ginger juice is the juice cleaned using fresh ginger rhizome, squeezed after peeling.
The rice vinegar uses the rice vinegar of States Pharmacopoeia specifications.
A kind of leech processing procedure, includes the following steps,
S1, the pretreatment of raw material: leech, ginger juice and rice vinegar are weighed up in proportion, and ginger juice and rice vinegar press the weight of 1:1
Amount part ratio is mixed and made into ginger rice vinegar juice, picks the impurity in leech, spare；
S2, the bored profit leech of ginger rice vinegar juice: leech is uniformly mixed with ginger rice vinegar juice, the bored profit of room temperature 5 hours, during which every
It was stirred 1 time every 0.5 hour, so that it is evenly distributed, the leech after obtaining bored profit is spare；
Leech after bored profit is dried and is crushed by S3: after the leech small fire fried dry after bored profit, being placed in baking oven, through 50
It is DEG C dry 5 hours, dry to water content 10% hereinafter, crushing is fine powder.
Embodiment 2,
A kind of leech processing formula, the component including following parts by weight:
100 parts of leech, 60 parts of ginger rice vinegar juice；The ginger rice vinegar juice presses the parts by weight of 1:1 using ginger juice and rice vinegar
Ratio is mixed.
The leech selects States Pharmacopoeia specifications Hirudinidae animal leech, and uniform in size coloury dry all.
The ginger juice is the juice cleaned using fresh ginger rhizome, squeezed after peeling.
The rice vinegar uses the rice vinegar of States Pharmacopoeia specifications.
A kind of leech processing procedure, includes the following steps,
S1, the pretreatment of raw material: leech, ginger juice and rice vinegar are weighed up in proportion, and ginger juice and rice vinegar press the weight of 1:1
Amount part ratio is mixed and made into ginger rice vinegar juice, picks the impurity in leech, spare；
S2, the bored profit leech of ginger rice vinegar juice: leech is uniformly mixed with ginger rice vinegar juice, the bored profit of room temperature 7 hours, during which every
It was stirred 1 time every 1.5 hours, so that it is evenly distributed, the leech after obtaining bored profit is spare；
Leech after bored profit is dried and is crushed by S3: after the leech small fire fried dry after bored profit, being placed in baking oven, through 70
It is DEG C dry 7 hours, dry to water content 20% hereinafter, crushing is fine powder.
Embodiment 3,
A kind of leech processing formula, the component including following parts by weight:
100 parts of leech, 40 parts of ginger rice vinegar juice；The ginger rice vinegar juice presses the parts by weight of 1:1 using ginger juice and rice vinegar
Ratio is mixed.
The leech selects States Pharmacopoeia specifications Hirudinidae animal leech, and uniform in size coloury dry all.
The ginger juice is the juice cleaned using fresh ginger rhizome, squeezed after peeling.
The rice vinegar uses the rice vinegar of States Pharmacopoeia specifications.
A kind of leech processing procedure, includes the following steps,
S1, the pretreatment of raw material: leech, ginger juice and rice vinegar are weighed up in proportion, and ginger juice and rice vinegar press the weight of 1:1
Amount part ratio is mixed and made into ginger rice vinegar juice, picks the impurity in leech, spare；
S2, the bored profit leech of ginger rice vinegar juice: leech is uniformly mixed with ginger rice vinegar juice, the bored profit of room temperature 6 hours, during which every
It was stirred 1 time every 1 hour, so that it is evenly distributed, the leech after obtaining bored profit is spare；
Leech after bored profit is dried and is crushed by S3: after the leech small fire fried dry after bored profit, being placed in baking oven, through 60
It is DEG C dry 6 hours, dry to water content 15% hereinafter, crushing is fine powder.
Embodiment 4,
A kind of leech processing formula, the component including following parts by weight:
100 parts of leech, 30 parts of ginger rice vinegar juice；The ginger rice vinegar juice presses the parts by weight of 1:1 using ginger juice and rice vinegar
Ratio is mixed.
The leech selects States Pharmacopoeia specifications Hirudinidae animal leech, and uniform in size coloury dry all.
The ginger juice is the juice cleaned using fresh ginger rhizome, squeezed after peeling.
The rice vinegar uses the rice vinegar of States Pharmacopoeia specifications.
A kind of leech processing procedure, includes the following steps,
S1, the pretreatment of raw material: leech, ginger juice and rice vinegar are weighed up in proportion, and ginger juice and rice vinegar press the weight of 1:1
Amount part ratio is mixed and made into ginger rice vinegar juice, picks the impurity in leech, spare；
S2, the bored profit leech of ginger rice vinegar juice: leech is uniformly mixed with ginger rice vinegar juice, the bored profit of room temperature 5.5 hours, during which
It was stirred 1 time every 0.75 hour, so that it is evenly distributed, the leech after obtaining bored profit is spare；
Leech after bored profit is dried and is crushed by S3: after the leech small fire fried dry after bored profit, being placed in baking oven, through 55
It is DEG C dry 5.5 hours, dry to water content 12.5% hereinafter, crushing is fine powder.
Embodiment 5,
A kind of leech processing formula, the component including following parts by weight:
100 parts of leech, 50 parts of ginger rice vinegar juice；The ginger rice vinegar juice presses the parts by weight of 1:1 using ginger juice and rice vinegar
Ratio is mixed.
The leech selects States Pharmacopoeia specifications Hirudinidae animal leech, and uniform in size coloury dry all.
The ginger juice is the juice cleaned using fresh ginger rhizome, squeezed after peeling.
The rice vinegar uses the rice vinegar of States Pharmacopoeia specifications.
A kind of leech processing procedure, includes the following steps,
S1, the pretreatment of raw material: leech, ginger juice and rice vinegar are weighed up in proportion, and ginger juice and rice vinegar press the weight of 1:1
Amount part ratio is mixed and made into ginger rice vinegar juice, picks the impurity in leech, spare；
S2, the bored profit leech of ginger rice vinegar juice: leech is uniformly mixed with ginger rice vinegar juice, the bored profit of room temperature 6.5 hours, during which
It was stirred 1 time every 1.25 hours, so that it is evenly distributed, the leech after obtaining bored profit is spare；
Leech after bored profit is dried and is crushed by S3: after the leech small fire fried dry after bored profit, being placed in baking oven, through 65
It is DEG C dry 6.5 hours, dry to water content 17.5% hereinafter, crushing is fine powder.
Above embodiment is used to illustrate the present invention, rather than limits the invention, in spirit of the invention
In scope of protection of the claims, to any modifications and changes that the present invention makes, protection scope of the present invention is both fallen within.
Claims (8)
1. a kind of leech processes formula, which is characterized in that the component including following parts by weight:
100 parts of leech, 20-60 parts of ginger rice vinegar juice；The ginger rice vinegar juice presses the weight part ratio of 1:1 using ginger juice and rice vinegar
Example is mixed.
2. a kind of leech according to claim 1 processes formula, which is characterized in that the component including following parts by weight:
100 parts of leech, 40 parts of ginger rice vinegar juice；The ginger rice vinegar juice presses the weight ratio of 1:1 using ginger juice and rice vinegar
It is mixed.
3. a kind of leech according to claim 1 or 2 processes formula, which is characterized in that the leech selects States Pharmacopoeia specifications
Hirudinidae animal leech, and it is uniform in size coloury dry all.
4. a kind of leech according to claim 1 or 2 processes formula, which is characterized in that the ginger juice is using fresh
Ginger rhizome clean, the juice that squeezes after peeling.
5. a kind of leech according to claim 1 or 2 processes formula, which is characterized in that the rice vinegar uses States Pharmacopoeia specifications
Rice vinegar.
6. a kind of leech processing procedure, which is characterized in that include the following steps,
S1, the pretreatment of raw material: leech, ginger juice and rice vinegar are weighed up in proportion, and ginger juice and rice vinegar press the parts by weight of 1:1
Ratio is mixed and made into ginger rice vinegar juice, picks the impurity in leech, spare；
S2, the bored profit leech of ginger rice vinegar juice: leech being uniformly mixed with ginger rice vinegar juice, room temperature bored profit 5-7 hours, during which every
It stirs 1 time within 0.5-1.5 hours, so that it is evenly distributed, the leech after obtaining bored profit is spare；
Leech after bored profit is dried and is crushed by S3: after the leech small fire fried dry after bored profit, being placed in baking oven, through 50-70 DEG C
It is 5-7 hours dry, it is dry to water content 10-20% hereinafter, crushing is fine powder.
7. a kind of leech processing procedure according to claim 6, which is characterized in that by leech and ginger in the step S2
Rice vinegar juice is uniformly mixed, during which the bored profit of room temperature 6 hours stirred 1 time every 1 hour, so that it is evenly distributed, the water after obtaining bored profit
Leech, it is spare.
8. a kind of leech processing procedure according to claim 6, which is characterized in that by the water after bored profit in the step S3
After leech small fire fried dry, it is placed in baking oven, it is 6 hours dry through 60 DEG C, it is dry to water content 15% hereinafter, crushing is fine powder.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113509492A (en) * | 2021-07-19 | 2021-10-19 | 安徽冠禅生物科技有限公司 | Dried leech processing technology |
| CN114869915A (en) * | 2022-05-07 | 2022-08-09 | 重庆多普泰制药股份有限公司 | Leech processing technology |
| CN114903921A (en) * | 2022-05-07 | 2022-08-16 | 重庆多普泰制药股份有限公司 | Leech processing process method |
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| CN113509492A (en) * | 2021-07-19 | 2021-10-19 | 安徽冠禅生物科技有限公司 | Dried leech processing technology |
| CN114869915A (en) * | 2022-05-07 | 2022-08-09 | 重庆多普泰制药股份有限公司 | Leech processing technology |
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Application publication date: 20190910 |