CN110215421A - A kind of skin care item preparation method promoting healthy gene expression in horn cell core - Google Patents
A kind of skin care item preparation method promoting healthy gene expression in horn cell core Download PDFInfo
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- CN110215421A CN110215421A CN201910426198.2A CN201910426198A CN110215421A CN 110215421 A CN110215421 A CN 110215421A CN 201910426198 A CN201910426198 A CN 201910426198A CN 110215421 A CN110215421 A CN 110215421A
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- skin care
- gene expression
- care item
- horn cell
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/342—Alcohols having more than seven atoms in an unbroken chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
Abstract
A kind of skin care item preparation method for promoting healthy gene expression in horn cell core of the disclosure of the invention of this composite skin care product preparation technical field, it according to component ratio includes: phytol that this, which can promote the composition of the raw material of skin care articles of healthy gene expression in aging cutin nucleus: 0.1-3 parts；Wild soybean seed extract: 0.1-2 parts；1,3 propylene glycol: 3 parts；Glycerol: 5 parts；The present invention can promote LAMIN-A, LAP-2, the expression of RANBP-17 protein, increase nucleus nuclear Pore Complex transport capacity, it improves, the transmission quantity of protein and mRNA in nuclear Pore Complex, and then improve the health of nucleus, to restore the kenel of cell health, and then reach skin, the improvement of skin horn cell, collocation Wild soybean seed extract, skin aging can be effectively improved, collagen and elastin laminin is promoted to generate, and present invention can apply to the facial mask essences in skin care item, Essence, lotion, the addition of maintenance skin effect object of cream, and protect product stability.
Description
Technical field
The present invention relates to skin care field more particularly to a kind of skin care item for promoting healthy gene expression in horn cell core
Preparation method.
Background technique
Skin care item are many kinds of on the market at present, and effect is different, including whitening, moisturizing, nti-freckle and anti-aging etc..But it is very much
Product is more or less added to some chemical substances being harmful to the human body, although these substances have short-term beauty to the skin of people
The skin care effects such as white, anti-aging can make skin severely damaged, long acne, color spot and oil occur instead but if being used for a long time
Rouge dyssecretosis etc.；With development in science and technology, personal care articles chemical raw material developing way develops towards epigenetics, imitates now
Between there are many for difference, the personal care articles raw material of gene expression regulation, however for LAMIN-A regulation protein gene
Not yet being applied to using but for aspect is personal, and in nursing product, the medicine of early ageing disease is seated mainly for the research of LAMIN-A
Research, but in exploring LAMIN-A protein for nucleus, when the relevance of health, it was found that regulate and control this section of gene sequence of LMNA
Column can effectively allow LAMIN-A protein expression, therefore can be applied to improve, the health of skin keratinocytes, this is tradition
Personal care articles raw material turns for cell anti-aging for another machine, and therefore, we have proposed be good in a kind of promotion horn cell core
The skin care item preparation method of health gene expression, to transfer the effect of reaching confrontation skin keratinocytes aging using different machines.
Summary of the invention
The purpose of the present invention is to solve disadvantages existing in the prior art, and a kind of promotion horn cell core proposed
The skin care item preparation method of interior health gene expression.
To achieve the goals above, present invention employs following technical solutions: healthy base in a kind of promotion horn cell core
Because of the skin care item preparation method of expression, in the promotion horn cell core composition of the raw material of skin care articles of healthy gene expression according to
Component ratio includes:
Phytol: 0.1-3 parts；
Wild soybean seed extract: 0.1-2 parts；
1,3 propylene glycol: 3 parts；
Glycerol: 5 parts.
Preferably, the skin care item preparation method that can promote healthy gene expression in aging cutin nucleus, this can
To promote the skin care item preparation method of healthy gene expression in aging cutin nucleus to include the following steps:
S1: raw material screening: by the component of compositing formula in claim 1 than being equipped with raw material: phytol: 0.1-3 parts；
Wild soybean seed extract: 0.1-2 parts；1,3 propylene glycol: 3 parts；Glycerol: 5 parts；
S2: stir for the first time: by alcohol: 0.1-3 part and glycerol: 5 parts be dispersed in ultrasonic oscillator be sufficiently mixed it is uniform,
Then homogeneous 3min in homogenizer is poured the mixture into, it is spare to obtain mixture；
S3: second stirs: by Wild soybean seed extract: 0.1-2 parts and 1,3 propylene glycol: 3 parts are put into above-mentioned steps S1
It in resulting mixture, is stirred in ultrasonic oscillator, is cooled to 40 DEG C or less the faces being added in skin care item
In film Essence, Essence, lotion or cream, composition finished product is obtained.
Preferably, the mosscelltec No.1 biochemical using hundred pleasure of Switzerland's rice of phytol used in described composition,
The Lysofix of Wild soybean seed extract U.S. Kemin.
Preferably, the cooling in the step S3 is natural cooling.
Preferably, homogenizer model RX-200l in the step S2.
A kind of skin care item preparation method promoting healthy gene expression in horn cell core provided by the invention, can promote
The expression of LAMIN-A, LAP-2, RANBP-17 protein makes nucleus nuclear Pore Complex transport capacity increase, improve, protein
With mRNA nuclear Pore Complex transmission quantity, and then improve nucleus health, to restore the kenel of cell health, Jin Erda
To skin, the improvement of skin horn cell, Wild soybean seed extract of arranging in pairs or groups can be effectively improved skin aging, promote to promote collagen and elasticity
Albumen generates, and present invention can apply to the facial mask essence in skin care item, Essence, lotion, the maintenance skin function of cream
The addition of object is imitated, and protects product stability.
Detailed description of the invention
Fig. 1 is preparation flow figure of the present invention；
Fig. 2 is the test cell line comparison diagram of the present invention with phytol and small liwan moss；
Fig. 3 is the comparison diagram of the Wild soybean seed extract added and blank of the invention.
Specific embodiment
In order to make the objectives, technical solutions, and advantages of the present invention clearer, below in conjunction with specific embodiment, to this
Invention is further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, not
For limiting the present invention.
A kind of skin care item preparation method promoting healthy gene expression in horn cell core is good in the promotion horn cell core
The composition of the raw material of skin care articles of health gene expression includes: according to component ratio
Phytol: 0.1-3 parts；
Wild soybean seed extract: 0.1-2 parts；
1,3 propylene glycol: 3 parts；
Glycerol: 5 parts.
The skin care item preparation method of healthy gene expression includes the following steps: in the promotion horn cell core
S1: raw material screening: by the component of compositing formula in claim 1 than being equipped with raw material: phytol: 0.1-3 parts；
Wild soybean seed extract: 0.1-2 parts；1,3 propylene glycol: 3 parts；Glycerol: 5 parts；
S2: stir for the first time: by alcohol: 0.1-3 part and glycerol: 5 parts be dispersed in ultrasonic oscillator be sufficiently mixed it is uniform,
Then homogeneous 3min in homogenizer is poured the mixture into, it is spare to obtain mixture；
S3: second stirs: by Wild soybean seed extract: 0.1-2 parts and 1,3 propylene glycol: 3 parts are put into above-mentioned steps S1
It in resulting mixture, is stirred in ultrasonic oscillator, is cooled to 40 DEG C or less the faces being added in skin care item
In film Essence, Essence, lotion or cream, composition finished product is obtained.
Wherein, phytol used in described composition is wild using the happy biochemical mosscelltec No.1 of Switzerland's rice hundred
The Lysofix of soybean seed extract U.S. Kemin；Cooling in the step S3 is natural cooling；Homogeneous in the step S2
Machine model RX-200l.
Fig. 2, PhyscomitrellaPatensExtract are phytol used in the present invention, from small liwan moss
It is extracted in PhyscomitrellaPatens.
Test cell line is carried out respectively with skin keratinocytes that 20 years old women and 55 years old women provide；
Tester: 0.33% small liwan moss extract and 1% small liwan moss extract；
Experiment process is cultivated 24 hours in substances；
Detection project: the related gene expression of nucleus pore structure and nucleopore transport.
The controlling gene of LMNA:Lamin-A nuclear membrane albumen
The controlling gene of TMPO:LAP-2 albumen, function are aggregation nuclear membrane albumen
RANBP17: being responsible for nucleopore and transport receptor, for the gene for regulating and controlling Protein-17RNA binding function
Fig. 3, the Wild soybean seed extract of addition are the Lysofix of U.S. KEMIN；
Compared with blank control, Lysofix increases the generation up to 102% of elastin laminin and the life of a collagen type peptide
At up to 49%.
It although an embodiment of the present invention has been shown and described, for the ordinary skill in the art, can be with
A variety of variations, modification, replacement can be carried out to these embodiments without departing from the principles and spirit of the present invention by understanding
And modification, the scope of the present invention is defined by the appended.
Claims (5)
1. a kind of skin care item preparation method for promoting healthy gene expression in horn cell core, it is characterised in that: the promotion cutin
The composition of the raw material of skin care articles of healthy gene expression includes: according to component ratio in nucleus
Phytol: 0.1-3 parts；
Wild soybean seed extract: 0.1-2 parts；
1,3 propylene glycol: 3 parts；
Glycerol: 5 parts.
2. a kind of skin care item preparation method as described in claim 1 for promoting healthy gene expression in horn cell core, special
Sign is: the skin care item preparation method of healthy gene expression includes the following steps: in the promotion horn cell core
S1: raw material screening: by the component of compositing formula in claim 1 than being equipped with raw material: phytol: 0.1-3 parts；Wild soybean
Seed extract: 0.1-2 parts；1,3 propylene glycol: 3 parts；Glycerol: 5 parts；
S2: stir for the first time: by alcohol: 0.1-3 part and glycerol: 5 parts be dispersed in ultrasonic oscillator be sufficiently mixed it is uniform, then
Homogeneous 3min in homogenizer is poured the mixture into, it is spare to obtain mixture；
S3: second stirs: by Wild soybean seed extract: 0.1-2 parts and 1,3 propylene glycol: 3 parts are put into obtained by above-mentioned steps S1
Mixture in, stirred in ultrasonic oscillator, be cooled to 40 DEG C or less be added skin care item in facial mask essence
In magnificent liquid, Essence, lotion or cream, composition finished product is obtained.
3. a kind of skin care item preparation method for promoting healthy gene expression in horn cell core according to claim 1 or 2,
It is characterized by: phytol used in described composition is using the happy biochemical mosscelltec No.1 of Switzerland's rice hundred, it is wild big
The Lysofix of beans seed extract U.S. Kemin.
4. a kind of skin care item preparation method for promoting healthy gene expression in horn cell core according to claim 2,
Be characterized in that: the cooling in the step S3 is natural cooling.
5. a kind of skin care item preparation method for promoting healthy gene expression in horn cell core according to claim 2,
It is characterized in that: homogenizer model RX-200l in the step S2.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910426198.2A CN110215421A (en) | 2019-05-21 | 2019-05-21 | A kind of skin care item preparation method promoting healthy gene expression in horn cell core |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910426198.2A CN110215421A (en) | 2019-05-21 | 2019-05-21 | A kind of skin care item preparation method promoting healthy gene expression in horn cell core |
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| CN110215421A true CN110215421A (en) | 2019-09-10 |
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| CN201910426198.2A Pending CN110215421A (en) | 2019-05-21 | 2019-05-21 | A kind of skin care item preparation method promoting healthy gene expression in horn cell core |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114191342A (en) * | 2021-11-23 | 2022-03-18 | 广州国色天香生物科技有限公司 | Skin care lotion for promoting skin metabolism and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001066080A1 (en) * | 2000-03-07 | 2001-09-13 | Avon Products, Inc. | Methods using phytol to improve the appearance of skin and compositions for such methods |
| US20030165456A1 (en) * | 2001-05-14 | 2003-09-04 | Avon Products | Skin care compositions and methods of improving aesthetic appearance of skin using same |
| CN108379213A (en) * | 2016-12-14 | 2018-08-10 | 天津强微特生物科技有限公司 | A kind of moisture-keeping crease-shedding hand lotion |
| CN108524354A (en) * | 2018-04-26 | 2018-09-14 | 广州抓猫电子商务有限公司 | Skin care compositions, facial treatment mask and preparation method thereof |
-
2019
- 2019-05-21 CN CN201910426198.2A patent/CN110215421A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001066080A1 (en) * | 2000-03-07 | 2001-09-13 | Avon Products, Inc. | Methods using phytol to improve the appearance of skin and compositions for such methods |
| US20030165456A1 (en) * | 2001-05-14 | 2003-09-04 | Avon Products | Skin care compositions and methods of improving aesthetic appearance of skin using same |
| CN108379213A (en) * | 2016-12-14 | 2018-08-10 | 天津强微特生物科技有限公司 | A kind of moisture-keeping crease-shedding hand lotion |
| CN108524354A (en) * | 2018-04-26 | 2018-09-14 | 广州抓猫电子商务有限公司 | Skin care compositions, facial treatment mask and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 王建新 主编: "《化妆品植物原料大全》", 30 June 2012, 中国纺织出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114191342A (en) * | 2021-11-23 | 2022-03-18 | 广州国色天香生物科技有限公司 | Skin care lotion for promoting skin metabolism and preparation method thereof |
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Application publication date: 20190910 |