CN110215309B - Lifting type particle size selection atomization drug delivery device - Google Patents
Lifting type particle size selection atomization drug delivery device Download PDFInfo
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- CN110215309B CN110215309B CN201910473323.5A CN201910473323A CN110215309B CN 110215309 B CN110215309 B CN 110215309B CN 201910473323 A CN201910473323 A CN 201910473323A CN 110215309 B CN110215309 B CN 110215309B
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- particle size
- cyclone separator
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
Abstract
The invention relates to a lifting type selective particle size atomization drug delivery device which comprises a lifting type air outlet pipe (3), a convergent cyclone separator (9), Venturi spray (5) and an air inlet guide pipe (4), wherein an air suction cover (8) is arranged at the lower end of the lifting type air outlet pipe (3), the air suction cover (8) is arranged in the convergent cyclone separator (9), and the Venturi spray (5) is connected with the convergent cyclone separator (9) through the air inlet guide pipe (4). Compared with the prior art, the invention atomizes and sprays the liquid medicine through compressed air and a Venturi type sprayer, collects liquid drops with the particle size not larger than a certain value by using a convergent cyclone separator with a large lower part and a small upper part and a liftable air outlet pipe with an air suction cover, guides the liquid drops into a toxicant exposure cabinet for administration, and monitors the diameter of the liquid drops by using a real-time particle size spectrometer.
Description
Technical Field
The invention relates to a lifting type particle size selection atomization drug delivery device. The generated liquid medicine can be selected in grain size and guided into a toxicant exposure cabinet (cavity) which is inhaled to be used as a sample generator of toxicant exposure equipment.
Background
Inhalation toxicity experiments are important means for researching inhalation toxicity of chemical poisons through respiratory tracts, toxic action mechanisms, prevention and treatment measures and the like, and are widely applied to the fields of environment, sanitation, medicine and the like at present. With the development of international inhalation toxicology, the domestic demand for inhalation toxicity research is increasing. Toxicant exposure cabinets for inhalation toxicity studies are generally divided into dynamic and static types. Wherein, dynamic contamination is more advantageous than static contamination because of the air exchange and the less influence of the animal breath and body temperature on the contamination process. According to the current situation, dynamic contamination instead of static contamination has become a trend.
The sample generator is an important component of inhalation contamination device, and the current mainstream sample generators are solid powder aerosol generator and liquid aerosol generator. These two generators can generate solid and gas aerosols separately, but the particle size of the aerosol-generating sample cannot be selected. The particle size of the contaminated sample has an important influence on the research of inhalation toxicity, so that the sample generation device capable of selecting the particle size can certainly further promote the development of the industry.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provide an atomization drug delivery device capable of selecting the particle size of a sample, which is a lifting type particle size selection atomization drug delivery device with the characteristics of simple structure, easy operation, quick response and the like.
The purpose of the invention can be realized by the following technical scheme: the utility model provides a particle size atomizing device of dosing is selected to over-and-under type, its characterized in that, the device include over-and-under type outlet duct, convergent type cyclone, venturi spraying, the pipe of admitting air, over-and-under type outlet duct lower extreme be equipped with the cover that induced drafts, induced drafts the cover and arranges in convergent type cyclone, venturi spraying connect convergent type cyclone through the pipe of admitting air.
The height of the lifting air outlet pipe is adjusted according to the particle size of the liquid medicine to be inhaled, so that the lower edge of the air suction cover is positioned at a certain fixed height, and the air flow with the particle size not exceeding a set value can be inhaled. The lower edge of the air suction cover at the lower end of the air outlet pipe is positioned at a certain specific layer height by adjusting the liftable air outlet pipe, so that the obtained air flow with the fixed particle size can be guided into the inhalation toxicant exposure cabinet to carry out subsequent sample inhalation toxicity exposure. The rest large liquid drops are thrown to the wall and flow down, and are discharged through a liquid discharge pipe.
The upper limit of the height of the suction hood is at least 3cm lower than the inlet of the air inlet duct, and the lower limit of the height of the suction hood is lower than the height of the maximum diameter of the convergent cyclone separator. The height of the lower edge of the air suction cover must be lower than the height of the air inlet guide pipe opening, so that the liquid medicine entering from the air inlet guide pipe opening is prevented from being directly sucked away, and the height of the lower edge of the air suction cover must be higher than the height of the liquid level at the bottom of the convergent cyclone separator, so that the liquid collected by the convergent cyclone separator is prevented from being sucked into the air suction cover.
The particle size of the liquid medicine to be inhaled is monitored by a dynamic particle size tester.
The liquid medicine is sprayed into a spray form by venturi through compressed air and enters the convergent cyclone separator through the air inlet duct.
The lifting air outlet pipe is inserted into the convergence type cyclone separator from the opening at the top of the convergence type cyclone separator, and a clasping ring and a sealing ring are arranged at the joint of the lifting air outlet pipe and the convergence type cyclone separator.
The bottom of the convergent cyclone separator is provided with a liquid discharge pipe and a valve, large liquid drops are thrown to the wall to flow down, are discharged through the liquid discharge pipe and the valve and are reused in the Venturi spray-in device again, and the sample amount is saved.
The convergent cyclone separator is in an inner convergent shape with a large lower part and a small upper part, the linear speed of the airflow is continuously increased in the downward rotating process, and smaller liquid drops are sequentially separated. The internally converging cyclone separator has the advantages of simple structure, high operation elasticity and high efficiency.
The dosage and the dosage concentration can be obtained by the air quantity, the consumption of the liquid medicine and the parameters of the test cabinet.
Compared with the prior art, the invention has the following advantages:
1. the invention relates to a lifting type particle size selection atomization drug delivery device, which comprises: lifting air outlet pipe (lower end connected with air suction cover), convergent cyclone separator (with lifting pipe ring and sealing ring between separator and air outlet pipe to ensure sealing), venturi sprayer, air inlet guide pipe, liquid discharge pipe and valve. The liquid medicine passes through the venturi sprayer through compressed air to form spray, and enters the cyclone separator through the air inlet conduit. The separator is of an inward convergent type with large lower part and small upper part, the linear speed of the airflow is continuously increased in the downward rotating process, so that smaller and smaller liquid drops are separated, the liquid drops are thrown to the wall to flow downwards, and the liquid drops can be added into the liquid medicine again after being discharged through the liquid discharge pipe. At the moment, the lower edge of the lower end air suction hood of the lifting air outlet pipe is positioned at a certain fixed height by adjusting the lifting air outlet pipe, so that air flow with the particle size not exceeding a certain value can be sucked, and the air flow is guided into a toxicant exposure cabinet for toxicant exposure, and the particle size of a sample is selected. The device utilizes compressed air to spray the liquid medicine into the cyclone separator through the venturi atomizer. The dosage and the dosage concentration are obtained by the parameters of air quantity, pure consumption of the liquid medicine (after the liquid medicine is removed and recycled) and a contamination cabinet. The particle size of the drops was monitored by a dynamic particle size spectrometer.
2. The invention provides a liquid inhalation contamination sample generating device capable of selecting particle size; simple structure, easy operation and rapid reaction.
3. Compressed air is introduced into the Venturi sprayer to atomize the liquid medicine, and the influence on various parameters in the subsequent toxicant exposure cabinet is small.
Drawings
FIG. 1 is a schematic view of a lifting type selective particle size atomization drug delivery device of the present invention;
fig. 2 is a top view of the device.
Detailed Description
The invention is described in detail below with reference to the figures and specific embodiments.
Example 1
As shown in fig. 1-2, a lifting type selective particle size atomization drug delivery device comprises a lifting type air outlet pipe 3, a convergence type cyclone separator 9, venturi spray 5 and an air inlet guide pipe 4, wherein the lifting type air outlet pipe 3 is inserted into the convergence type cyclone separator 9 from an opening at the top of the convergence type cyclone separator, and a holding ring and a sealing ring 2 are arranged at the joint of the lifting type air outlet pipe 3 and the convergence type cyclone separator 9 to ensure sealing; the lower end of the lifting air outlet pipe 3 is provided with an air suction cover 8, the air suction cover 8 is arranged in a convergent cyclone separator 9,
the height of the lifting type air outlet pipe 3 is adjusted according to the particle size of the liquid medicine to be inhaled, so that the lower edge of the air suction cover 8 is positioned at a certain fixed height, and the air flow with the particle size not exceeding a set value can be inhaled. The lower edge of the air suction cover at the lower end of the air outlet pipe is positioned at a certain specific layer height by adjusting the liftable air outlet pipe, so that the obtained air flow with the fixed particle size can be guided into the inhalation toxicant exposure cabinet to carry out subsequent sample inhalation toxicity exposure. The rest large liquid drops are thrown to the wall and flow down, and are discharged through a liquid discharge pipe. The upper limit of the height of the suction hood 8 is at least 3cm lower than the inlet of the air inlet duct 4, and the lower limit is lower than the height of the maximum diameter of the convergent cyclone separator 9. The particle size of the liquid medicine to be inhaled is monitored by a dynamic particle size tester.
The venturi spray 5 is connected with a convergent cyclone separator 9 through an air inlet conduit 4. The liquid medicine passes through the venturi spray 5 by compressed air to form spray, and enters the convergent cyclone 9 from the air inlet duct 4.
The bottom of the convergent cyclone separator 9 is provided with a liquid discharge pipe and a valve 1, large liquid drops are thrown to the wall to flow down, are discharged through the liquid discharge pipe and the valve 1 and are sprayed into the device again through the Venturi spray 5 to be reused, and the sample amount is saved.
The convergent cyclone separator 9 is in an inner convergent shape with a large lower part and a small upper part, the linear speed of the airflow is continuously increased in the downward rotating process, and the liquid drops which are smaller and smaller are sequentially separated.
The specific operation process is as follows:
as shown in fig. 1, a certain amount of liquid medicine is connected with a venturi spray 5, compressed air 7 is introduced, then the liquid medicine 6 is introduced into a convergent cyclone separator 9 (large at the bottom and small at the top) through an air inlet conduit 4, and in the process that the airflow rotates downwards, the linear velocity is continuously increased, and liquid drops which are smaller and smaller are sequentially separated. At the moment, the lifting type air outlet pipe 3 is adjusted to enable the lower end air suction cover 8 to be at a specific height, sample air flow with the particle size not larger than a certain value is obtained, the sample air flow is guided into the contamination device for inhalation toxicity research, large liquid drops are thrown onto the wall to flow downwards, are discharged through the air exhaust pipe, and can be added back into the liquid medicine again.
In the process, the generated sample granularity can be dynamically monitored through a real-time dynamic particle size spectrometer, and the sample granularity can be adjusted by adjusting the height of the air suction cover 8. The dosage and the concentration of the medicine can be obtained by the air quantity of the compressed air, the pure consumption of the liquid medicine and various parameters of the experimental toxicant exposure cabinet.
It will be appreciated by persons skilled in the art that the above embodiments are illustrative only and not intended to be limiting, and that changes and modifications may be made to the above embodiments without departing from the true spirit of the invention and the scope of the appended claims.
Claims (4)
1. A lifting type atomization dosing device with particle size selection is characterized by comprising a lifting type air outlet pipe (3), a convergence type cyclone separator (9), Venturi mist spray (5) and an air inlet guide pipe (4), wherein an air suction cover (8) is arranged at the lower end of the lifting type air outlet pipe (3), the air suction cover (8) is arranged in the convergence type cyclone separator (9), and the Venturi mist spray (5) is connected with the convergence type cyclone separator (9) through the air inlet guide pipe (4);
according to the particle size of the liquid medicine to be inhaled, the height of the lifting type air outlet pipe (3) is adjusted, so that the lower edge of the air suction cover (8) is positioned at a certain fixed height, and the air flow with the particle size not exceeding a set value can be inhaled;
the upper limit of the height of the air suction hood (8) is at least 3cm lower than the opening of the air inlet guide pipe (4), and the lower limit of the height of the air suction hood is lower than the height of the maximum diameter of the convergent cyclone separator (9);
the convergent cyclone separator (9) is in an inner convergent shape with a large lower part and a small upper part, the linear speed of the airflow is continuously increased in the downward rotating process, and smaller liquid drops are sequentially separated;
the device utilizes compressed air to spray liquid medicine into a cyclone separator through a Venturi sprayer, the dosage and the dosage concentration are obtained through the air quantity, the pure consumption of the liquid medicine and the parameters of the contamination cabinet, and the particle size of medicine drops is monitored through a dynamic particle size spectrometer.
2. The lifting type selective particle size atomization drug delivery device according to claim 1, characterized in that the liquid medicine is sprayed by compressed air through a venturi spray (5) and enters a convergent cyclone (9) from an air inlet duct (4).
3. The lifting type selective particle size atomization drug delivery device according to claim 1, characterized in that the lifting type gas outlet pipe (3) is inserted into the top opening of the convergent cyclone separator (9), and a holding ring and a sealing ring (2) are arranged at the joint of the lifting type gas outlet pipe (3) and the convergent cyclone separator (9).
4. The lifting type selective particle size atomization drug delivery device according to claim 1, characterized in that a drain pipe and a valve (1) are arranged at the bottom of the convergent cyclone separator (9), large liquid drops are thrown to the wall to flow down, and are discharged through the drain pipe and the valve (1) to be sprayed into the device again through the venturi spray (5) for reuse.
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| CN201910473323.5A CN110215309B (en) | 2019-05-31 | 2019-05-31 | Lifting type particle size selection atomization drug delivery device |
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| CN110215309B true CN110215309B (en) | 2022-03-18 |
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| CN110584828A (en) * | 2019-10-31 | 2019-12-20 | 中国人民解放军陆军军医大学第一附属医院 | Atomizing bronchus toxicant exposure device under bronchofiberscope guide |
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