CN110215309A - A kind of lift selection partial size atomized medicine introducing device - Google Patents

A kind of lift selection partial size atomized medicine introducing device Download PDF

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Publication number
CN110215309A
CN110215309A CN201910473323.5A CN201910473323A CN110215309A CN 110215309 A CN110215309 A CN 110215309A CN 201910473323 A CN201910473323 A CN 201910473323A CN 110215309 A CN110215309 A CN 110215309A
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China
Prior art keywords
partial size
cyclone separator
type cyclone
lift
convergence type
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CN201910473323.5A
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CN110215309B (en
Inventor
董学胜
洪丽玲
徐桐桐
张小沁
徐晨
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Shanghai Chemical Institute Testing Co Ltd
Shanghai Research Institute of Chemical Industry SRICI
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Shanghai Chemical Institute Testing Co Ltd
Shanghai Research Institute of Chemical Industry SRICI
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61DVETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D7/00Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nozzles (AREA)
  • Sampling And Sample Adjustment (AREA)

Abstract

The present invention relates to a kind of lifts to select partial size atomized medicine introducing device, the device includes lift escape pipe (3), convergence type cyclone separator (9), venturi spray (5), air induction conduit (4), lift escape pipe (3) lower end is equipped with suspended hood (8), suspended hood (8) is placed in convergence type cyclone separator (9), and the venturi spray (5) passes through air induction conduit (4) connection convergence type cyclone separator (9).Compared with prior art, the present invention is sprayed into medical liquid atomizing by compressed air and venturi type sprayer, Liftable type escape pipe collection cut size using down big up small convergence type cyclone separator and with suspended hood is not more than the drop of a certain value, it imports in toxicant exposure cabinet and is administered, medicine drop diameter is monitored using real-time partial size spectrometer, it be selected with partial size can be dripped to medicine, structure is simple, easily operated and the advantages that be swift in response.

Description

A kind of lift selection partial size atomized medicine introducing device
Technical field
The present invention relates to a kind of lifts to select partial size atomized medicine introducing device.The medical fluid partial size of generation can be selected It selects, imported into the sample generator in the toxicant exposure cabinet (chamber) of Inhalation as contamination equipment.
Background technique
Toxicity on inhalation experiment is research weight of the chemical toxicant through respiratory tract toxicity on inhalation, toxic action mechanism and control measure etc. Means are wanted, have been widely used in the fields such as environment, health and medicine at present.It is domestic with the development of international inhalation toxicology Demand to EXPERIMENT STUDY ON SUBCHRONIC also increasingly increases.Toxicant exposure cabinet for EXPERIMENT STUDY ON SUBCHRONIC is generally divided into dynamic formula and quiet formula two Kind.Wherein dynamic formula contamination is influenced smaller therefore right due to that can carry out air exchange, contamination process by animal breath and body temperature Advantage is had more than static exposure.According to current situation, dynamic formula contamination replaces static exposure to have become a kind of trend.
Sample generator is the important component of Inhalation device, and the sample generator of mainstream is solid powder at present Aerosol generator and liquid aersol generator.Solid and gas aerosols can occur respectively for both generators, still The particle size that aerosol sample occurs can not be selected.And sample particle diameter of contaminating have to the research of toxicity on inhalation it is important The sample generating device for influencing, therefore being able to carry out particle size selection necessarily can further push the development of industry.
Summary of the invention
It is an object of the present invention to overcome the above-mentioned drawbacks of the prior art and provide one kind can be to sample grain Diameter size carries out the atomized medicine introducing device of selection, and the apparatus structure is simple, easily operated and the features such as be swift in response lift Select partial size atomized medicine introducing device.
The purpose of the present invention can be achieved through the following technical solutions: a kind of lift selection partial size atomized medicine introducing dress It sets, which is characterized in that the device includes lift escape pipe, convergence type cyclone separator, venturi spray, air induction conduit, institute The lift escape pipe lower end stated is equipped with suspended hood, and suspended hood is placed in convergence type cyclone separator, the venturi spray Convergence type cyclone separator is connected by air induction conduit.
According to the partial size of medical fluid to be sucked, the height of lift escape pipe is adjusted, makes suspended hood lower edge in a certain fixation The i.e. inhalable partial size of height is no more than the air-flow of setting value.By adjusting liftable discharge pipe, make the suspended hood lower edge of its lower end On a certain specific floor height, thus after the air-flow for obtaining fixed particle size can import the progress of dynamic inhalation contamination cabinet Continuous sample toxicity on inhalation contamination.Remaining big drop, which is thrown on wall, to be flowed down, and is discharged through drain pipe.
The adjusting upper height limit of the suspended hood should be lower than air induction conduit mouth at least 3cm, and lower limit should be revolved lower than convergence type Wind separator reaches the height of maximum gauge.That is suspended hood lower edge height has to be lower than air induction conduit open height, avoids from air inlet The medical fluid that conduit mouth enters directly is sucked away, and suspended hood lower edge height necessarily is greater than convergence type cyclone separator bottom liquid level Highly, it avoids the liquid of convergence type cyclone collection sucking suspended hood.
The partial size of the medical fluid to be sucked is monitored by dynamic particle size analyzer.
Medical fluid is formed by spraying by compressed air by venturi spray, enters convergence type cyclonic separation by air induction conduit Device.
The liftable escape pipe is inserted from convergence type cyclone separator top opening, and in liftable escape pipe Circle holding and sealing ring are equipped with the junction of convergence type cyclone separator.
The convergence type cyclone separator bottom is equipped with drain pipe and valve, and big drop is thrown on wall and flows down, and passes through Drain pipe is discharged with valve again through utilizing again in venturi spray jetting device, saves sample size.
The convergence type cyclone separator is in down big up small interior convergent contour, air-flow linear speed during rotation is downward Degree is continuously increased, successively by smaller and smaller drop separation.The structure of style of introversion cyclone separator is simple, operating flexibility is big, effect Rate is higher.
Dosage and administration concentration can be obtained by the parameter of air quantity, medical fluid consumption and experiment cabinet.
Compared with prior art, the invention has the following advantages that
1. lift of the present invention selects partial size atomized medicine introducing device, comprising: lift escape pipe (lower end is connected with suspended hood), Convergence type cyclone separator (has lifting pipe circle holding and sealing ring to guarantee sealing) between separator and escape pipe, venturi spray Device, air induction conduit, drain pipe and valve.Medical fluid is formed by venturi spray device by spraying, by air induction conduit by compressed air Into cyclone separator.The separator is in down big up small style of introversion, and air-flow linear velocity during rotation is downward constantly increases Add, with this by smaller and smaller drop separation, drop is thrown on wall and flows down, and can rejoin medicine by drain pipe discharge In liquid.At this time by adjusting lift discharge pipe, make its lower end suspended hood lower edge in the i.e. inhalable grain of a certain fixed height Diameter is no more than the air-flow of a certain value, is conducted into toxicant exposure cabinet and contaminates, so that the partial size to sample selects.The device Medical fluid is sprayed into cyclone separator by venturi spray device using compressed air.Dosage and administration concentration by air quantity, The pure consumption of medical fluid (after subduction released liquor) and the parameter of toxicant exposure cabinet obtain.The partial size of medicine drop passes through dynamic partial size spectrometer It is monitored.
2. the present invention provides a kind of liquid Inhalation sample generating devices that can choose partial size;Structure is simple, easy In operating, be swift in response.
3. being passed through venturi spray device using compressed air to be atomized medical fluid, to parameters shadow in subsequent toxicant exposure cabinet Sound is smaller.
Detailed description of the invention
Fig. 1 is that a kind of lift of the present invention selects partial size atomized medicine introducing device schematic diagram;
Fig. 2 is the top view of the device.
Specific embodiment
The present invention is described in detail with specific embodiment below in conjunction with the accompanying drawings.
Embodiment 1
As shown in Figs. 1-2, a kind of lift selects partial size atomized medicine introducing device, which includes lift escape pipe 3, receives Type cyclone separator 9, venturi spray 5, air induction conduit 4 are held back, liftable escape pipe 3 is opened at the top of convergence type cyclone separator 9 Mouth is inserted, and is equipped with circle holding and sealing ring 2 in the junction of liftable escape pipe 3 and convergence type cyclone separator 9, is guaranteed Sealing;3 lower end of lift escape pipe is equipped with suspended hood 8, and suspended hood 8 is placed in convergence type cyclone separator 9,
According to the partial size of medical fluid to be sucked, the height of lift escape pipe 3 is adjusted, makes 8 lower edge of suspended hood in a certain solid The i.e. inhalable partial size of fixed height is no more than the air-flow of setting value.By adjusting liftable discharge pipe, make under the suspended hood of its lower end Edge is on a certain specific floor height, so that the air-flow for obtaining fixed particle size can import the progress of dynamic inhalation contamination cabinet Subsequent sample toxicity on inhalation contamination.Remaining big drop, which is thrown on wall, to be flowed down, and is discharged through drain pipe.The suspended hood 8 Adjusting upper height limit be lower than 4 mouthfuls of at least 3cm of air induction conduit, lower limit should reach maximum gauge lower than convergence type cyclone separator 9 Height.The partial size of the medical fluid to be sucked is monitored by dynamic particle size analyzer.
The venturi spray 5 connects convergence type cyclone separator 9 by air induction conduit 4.Medical fluid passes through compressed air It is formed by spraying by venturi spray 5, convergence type cyclone separator 9 is entered by air induction conduit 4.
9 bottom of convergence type cyclone separator is equipped with drain pipe and valve 1, and big drop is thrown on wall and flows down, It is discharged through drain pipe and valve 1 again through being utilized again in 5 jetting device of venturi spray, saves sample size.
The convergence type cyclone separator 9 is in down big up small interior convergent contour, air-flow line during rotation is downward Speed is continuously increased, successively by smaller and smaller drop separation.
Specific operation process is as described below:
As shown in Figure 1, take a certain amount of medical fluid connection venturi spray 5, import after compressed air 7 by medical fluid 6 by into Airway 4 is imported into convergence type cyclone separator 9 (down big up small), and during flow rotation is downward, linear velocity constantly increases Add, successively by smaller and smaller drop separation.Lift escape pipe 3 is adjusted at this time, and lower end suspended hood 8 is made to be in a specific height Degree obtains the sample air stream that partial size is not more than a certain value, is conducted into contamination device and carries out EXPERIMENT STUDY ON SUBCHRONIC, big Drop is thrown on wall and flows down, and is discharged through air-exhausting duct, can be added back in medical fluid again.
In this process, dynamic monitoring can be carried out by sample granularity of the real-time dynamic particle size spectrometer to generation, adjusted Save the 8 adjustable sample particle diameter of height of suspended hood.Dosage and the concentration of drug can pass through the air quantity of compressed air, medical fluid The parameters of pure consumption and test toxicant exposure cabinet obtain.
Those of ordinary skill in the art it should be appreciated that more than specific embodiment be intended merely to illustrate this Invention, and be not used as limitation of the invention, as long as in spirit of the invention, to described above specific real Apply the variation of mode, modification will all be fallen within the scope of claims of the present invention.

Claims (8)

1. a kind of lift selects partial size atomized medicine introducing device, which is characterized in that the device includes lift escape pipe (3), receives Type cyclone separator (9), venturi spray (5), air induction conduit (4) are held back, lift escape pipe (3) lower end is equipped with air draught It covers (8), suspended hood (8) is placed in convergence type cyclone separator (9), and the venturi spray (5) is connected by air induction conduit (4) Type cyclone separator (9) are held back in reception.
2. a kind of lift according to claim 1 selects partial size atomized medicine introducing device, which is characterized in that according to be sucked The partial size of medical fluid adjusts the height of lift escape pipe (3), keeps suspended hood (8) lower edge i.e. inhalable in a certain fixed height Partial size is no more than the air-flow of setting value.
3. a kind of lift according to claim 2 selects partial size atomized medicine introducing device, which is characterized in that the air draught The adjusting upper height limit for covering (8) is lower than air induction conduit (4) mouth at least 3cm, and lower limit should reach lower than convergence type cyclone separator (9) The height of maximum gauge.
4. a kind of lift according to claim 2 selects partial size atomized medicine introducing device, which is characterized in that described wait inhale The partial size for entering medical fluid is monitored by dynamic particle size analyzer.
5. a kind of lift according to claim 1 selects partial size atomized medicine introducing device, which is characterized in that medical fluid passes through pressure Contracting air is formed by spraying by venturi spray (5), enters convergence type cyclone separator (9) by air induction conduit (4).
6. a kind of lift according to claim 1 selects partial size atomized medicine introducing device, which is characterized in that described rises Drop escape pipe (3) is inserted from convergence type cyclone separator (9) top opening, and in liftable escape pipe (3) and convergence type The junction of cyclone separator (9) is equipped with circle holding and sealing ring (2).
7. a kind of lift according to claim 1 selects partial size atomized medicine introducing device, which is characterized in that the convergence Type cyclone separator (9) bottom is equipped with drain pipe and valve (1), and big drop is thrown on wall and flows down, through drain pipe and valve (1) discharge again through utilizing again in venturi spray (5) jetting device.
8. a kind of lift according to claim 1 selects partial size atomized medicine introducing device, which is characterized in that the convergence Type cyclone separator (9) is in down big up small interior convergent contour, and air-flow linear velocity during rotation is downward is continuously increased, successively By smaller and smaller drop separation.
CN201910473323.5A 2019-05-31 2019-05-31 Lifting type particle size selection atomization drug delivery device Active CN110215309B (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110584828A (en) * 2019-10-31 2019-12-20 中国人民解放军陆军军医大学第一附属医院 Atomizing bronchus toxicant exposure device under bronchofiberscope guide

Citations (10)

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Publication number Priority date Publication date Assignee Title
CN201701589U (en) * 2010-06-02 2011-01-12 天卓睿丰医疗科技(北京)有限公司 Administration atomizer for respiratory tracts
CN102890026A (en) * 2012-10-26 2013-01-23 上海天科化工检测有限公司 Intake contamination sample feeding system for medically forced atomizing
CN103230638A (en) * 2013-04-26 2013-08-07 温红生 Atomizer having functions of adjusting sizes of atomized particles and filtering and atomization method thereof
CN203280863U (en) * 2013-04-26 2013-11-13 温红生 Adjusting structure for atomizer
CN104958814A (en) * 2015-07-03 2015-10-07 江苏鹿得医疗电子股份有限公司 Novel atomizing cup capable of adjusting atomizing particles
EP3017839A1 (en) * 2014-11-10 2016-05-11 Elettroplastica S.p.A. A device for nebulising substances for aerosols
CN205322945U (en) * 2016-01-27 2016-06-22 赵静 Breathe internal medicine and use intelligent nebulizer
CN105816945A (en) * 2016-05-11 2016-08-03 江苏鹿得医疗电子股份有限公司 Low-noise atomizing cup with adjustable atomization particles and adjustable atomization efficiency
CN106166317A (en) * 2016-08-25 2016-11-30 厦门雅信塑胶有限公司 The atomizing cup of adjustable atomizing particle size
CN109718431A (en) * 2017-10-31 2019-05-07 正大天晴药业集团股份有限公司 The medical atomizer that internal gas flow improves

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN201701589U (en) * 2010-06-02 2011-01-12 天卓睿丰医疗科技(北京)有限公司 Administration atomizer for respiratory tracts
CN102890026A (en) * 2012-10-26 2013-01-23 上海天科化工检测有限公司 Intake contamination sample feeding system for medically forced atomizing
CN103230638A (en) * 2013-04-26 2013-08-07 温红生 Atomizer having functions of adjusting sizes of atomized particles and filtering and atomization method thereof
CN203280863U (en) * 2013-04-26 2013-11-13 温红生 Adjusting structure for atomizer
EP3017839A1 (en) * 2014-11-10 2016-05-11 Elettroplastica S.p.A. A device for nebulising substances for aerosols
CN104958814A (en) * 2015-07-03 2015-10-07 江苏鹿得医疗电子股份有限公司 Novel atomizing cup capable of adjusting atomizing particles
CN205322945U (en) * 2016-01-27 2016-06-22 赵静 Breathe internal medicine and use intelligent nebulizer
CN105816945A (en) * 2016-05-11 2016-08-03 江苏鹿得医疗电子股份有限公司 Low-noise atomizing cup with adjustable atomization particles and adjustable atomization efficiency
CN106166317A (en) * 2016-08-25 2016-11-30 厦门雅信塑胶有限公司 The atomizing cup of adjustable atomizing particle size
CN109718431A (en) * 2017-10-31 2019-05-07 正大天晴药业集团股份有限公司 The medical atomizer that internal gas flow improves

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110584828A (en) * 2019-10-31 2019-12-20 中国人民解放军陆军军医大学第一附属医院 Atomizing bronchus toxicant exposure device under bronchofiberscope guide

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