CN110214015A - 用于治疗血栓栓塞的方法 - Google Patents

用于治疗血栓栓塞的方法 Download PDF

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Publication number
CN110214015A
CN110214015A CN201880007480.0A CN201880007480A CN110214015A CN 110214015 A CN110214015 A CN 110214015A CN 201880007480 A CN201880007480 A CN 201880007480A CN 110214015 A CN110214015 A CN 110214015A
Authority
CN
China
Prior art keywords
thrombolytics
thromboembolism
treating
accumulated dose
ultrasonic wave
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201880007480.0A
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English (en)
Chinese (zh)
Inventor
L·艾伦
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ekos LLC
Original Assignee
Ekos LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ekos LLC filed Critical Ekos LLC
Publication of CN110214015A publication Critical patent/CN110214015A/zh
Pending legal-status Critical Current

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/48Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/49Urokinase; Tissue plasminogen activator
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/22004Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
    • A61B17/22012Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement
    • A61B17/2202Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement the ultrasound transducer being inside patient's body at the distal end of the catheter
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/48Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482Serine endopeptidases (3.4.21)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0092Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B2017/22082Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for after introduction of a substance
    • A61B2017/22084Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for after introduction of a substance stone- or thrombus-dissolving
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B2017/22082Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for after introduction of a substance
    • A61B2017/22088Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for after introduction of a substance ultrasound absorbing, drug activated by ultrasound

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Surgery (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Anesthesiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Mechanical Engineering (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Surgical Instruments (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
CN201880007480.0A 2017-01-24 2018-01-23 用于治疗血栓栓塞的方法 Pending CN110214015A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762449966P 2017-01-24 2017-01-24
US62/449,966 2017-01-24
PCT/IB2018/050403 WO2018138634A1 (en) 2017-01-24 2018-01-23 Method for the treatment of thromboembolism

Publications (1)

Publication Number Publication Date
CN110214015A true CN110214015A (zh) 2019-09-06

Family

ID=61224209

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201880007480.0A Pending CN110214015A (zh) 2017-01-24 2018-01-23 用于治疗血栓栓塞的方法

Country Status (10)

Country Link
US (1) US20180206867A1 (ja)
EP (3) EP3936140B1 (ja)
JP (2) JP2020506907A (ja)
KR (1) KR20190110095A (ja)
CN (1) CN110214015A (ja)
AU (1) AU2018212778A1 (ja)
CA (1) CA3050858A1 (ja)
SG (1) SG11201906431UA (ja)
TW (1) TW201827074A (ja)
WO (1) WO2018138634A1 (ja)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002359576A1 (en) 2001-12-03 2003-06-17 Ekos Corporation Catheter with multiple ultrasound radiating members
US10182833B2 (en) 2007-01-08 2019-01-22 Ekos Corporation Power parameters for ultrasonic catheter
PL2170181T3 (pl) 2007-06-22 2014-08-29 Ekos Corp Sposób i aparat do leczenia wylewów wewnątrzczaszkowych
CN107708581B (zh) 2015-06-10 2021-11-19 Ekos公司 超声波导管
JP2020103418A (ja) * 2018-12-26 2020-07-09 株式会社三洋物産 遊技機
US11717139B2 (en) 2019-06-19 2023-08-08 Bolt Medical, Inc. Plasma creation via nonaqueous optical breakdown of laser pulse energy for breakup of vascular calcium
WO2020256898A1 (en) 2019-06-19 2020-12-24 Boston Scientific Scimed, Inc. Balloon surface photoacoustic pressure wave generation to disrupt vascular lesions
US11660427B2 (en) 2019-06-24 2023-05-30 Boston Scientific Scimed, Inc. Superheating system for inertial impulse generation to disrupt vascular lesions
US20200406009A1 (en) 2019-06-26 2020-12-31 Boston Scientific Scimed, Inc. Focusing element for plasma system to disrupt vascular lesions
US10792054B1 (en) 2019-07-11 2020-10-06 Eduardo Lorenzo Catheter for thromboembolic disease with mechanic waves, injection and ejection
US11583339B2 (en) 2019-10-31 2023-02-21 Bolt Medical, Inc. Asymmetrical balloon for intravascular lithotripsy device and method
US12102384B2 (en) 2019-11-13 2024-10-01 Bolt Medical, Inc. Dynamic intravascular lithotripsy device with movable energy guide
US11672599B2 (en) 2020-03-09 2023-06-13 Bolt Medical, Inc. Acoustic performance monitoring system and method within intravascular lithotripsy device
US20210290286A1 (en) 2020-03-18 2021-09-23 Bolt Medical, Inc. Optical analyzer assembly and method for intravascular lithotripsy device
US11707323B2 (en) 2020-04-03 2023-07-25 Bolt Medical, Inc. Electrical analyzer assembly for intravascular lithotripsy device
JP2021186294A (ja) * 2020-05-29 2021-12-13 株式会社三洋物産 遊技機
US12016610B2 (en) 2020-12-11 2024-06-25 Bolt Medical, Inc. Catheter system for valvuloplasty procedure
US11672585B2 (en) 2021-01-12 2023-06-13 Bolt Medical, Inc. Balloon assembly for valvuloplasty catheter system
US11648057B2 (en) 2021-05-10 2023-05-16 Bolt Medical, Inc. Optical analyzer assembly with safety shutdown system for intravascular lithotripsy device
US11806075B2 (en) 2021-06-07 2023-11-07 Bolt Medical, Inc. Active alignment system and method for laser optical coupling
US11839391B2 (en) 2021-12-14 2023-12-12 Bolt Medical, Inc. Optical emitter housing assembly for intravascular lithotripsy device
TWI848861B (zh) * 2023-11-21 2024-07-11 財團法人金屬工業研究發展中心 超音波輔助血栓消融裝置

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5399158A (en) * 1990-05-31 1995-03-21 The United States Of America As Represented By The Secretary Of The Army Method of lysing thrombi
JPH07265417A (ja) * 1994-04-01 1995-10-17 Katsuro Tachibana 薬物投与器具
US5509896A (en) * 1994-09-09 1996-04-23 Coraje, Inc. Enhancement of thrombolysis with external ultrasound
US5945432A (en) * 1995-12-22 1999-08-31 The University Of Vermont And State Agricultural College Thrombolytic agents and thienopyridine derivatives in acute stroke
US20020138036A1 (en) * 2001-03-21 2002-09-26 Eilaz Babaev Ultrasonic catheter drug delivery method and device
US20040122354A1 (en) * 2002-09-05 2004-06-24 Semba Charles P. Infusion catheter having an integrated doppler transducer
US20070265560A1 (en) * 2006-04-24 2007-11-15 Ekos Corporation Ultrasound Therapy System
US20080171965A1 (en) * 2007-01-08 2008-07-17 Ekos Corporation Power parameters for ultrasonic catheter
CN101505785A (zh) * 2006-08-29 2009-08-12 健泰科生物技术公司 替奈普酶用于治疗急性缺血性中风的用途
CN103228224A (zh) * 2010-08-27 2013-07-31 Ekos公司 用于治疗颅内出血的方法和设备
CN105025977A (zh) * 2013-03-14 2015-11-04 Ekos公司 用于将药物递送至靶部位的方法和设备

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5447509A (en) * 1991-01-11 1995-09-05 Baxter International Inc. Ultrasound catheter system having modulated output with feedback control
AU2002359576A1 (en) 2001-12-03 2003-06-17 Ekos Corporation Catheter with multiple ultrasound radiating members
WO2010075445A1 (en) * 2008-12-23 2010-07-01 Silk Road Medical, Inc. Methods and systems for treatment of acute ischemic stroke
US20110082396A1 (en) * 2009-10-06 2011-04-07 Wallace Michael P Ultrasound-enhanced stenosis therapy
US11458290B2 (en) * 2011-05-11 2022-10-04 Ekos Corporation Ultrasound system

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5399158A (en) * 1990-05-31 1995-03-21 The United States Of America As Represented By The Secretary Of The Army Method of lysing thrombi
JPH07265417A (ja) * 1994-04-01 1995-10-17 Katsuro Tachibana 薬物投与器具
US5509896A (en) * 1994-09-09 1996-04-23 Coraje, Inc. Enhancement of thrombolysis with external ultrasound
US5945432A (en) * 1995-12-22 1999-08-31 The University Of Vermont And State Agricultural College Thrombolytic agents and thienopyridine derivatives in acute stroke
US20020138036A1 (en) * 2001-03-21 2002-09-26 Eilaz Babaev Ultrasonic catheter drug delivery method and device
US20040122354A1 (en) * 2002-09-05 2004-06-24 Semba Charles P. Infusion catheter having an integrated doppler transducer
US20070265560A1 (en) * 2006-04-24 2007-11-15 Ekos Corporation Ultrasound Therapy System
CN101505785A (zh) * 2006-08-29 2009-08-12 健泰科生物技术公司 替奈普酶用于治疗急性缺血性中风的用途
US20080171965A1 (en) * 2007-01-08 2008-07-17 Ekos Corporation Power parameters for ultrasonic catheter
CN103228224A (zh) * 2010-08-27 2013-07-31 Ekos公司 用于治疗颅内出血的方法和设备
CN105361923A (zh) * 2010-08-27 2016-03-02 Ekos公司 用于治疗颅内出血的方法和设备
CN105025977A (zh) * 2013-03-14 2015-11-04 Ekos公司 用于将药物递送至靶部位的方法和设备

Also Published As

Publication number Publication date
US20180206867A1 (en) 2018-07-26
EP4272818A2 (en) 2023-11-08
JP2023120202A (ja) 2023-08-29
WO2018138634A1 (en) 2018-08-02
EP3936140A1 (en) 2022-01-12
SG11201906431UA (en) 2019-08-27
EP3573635B1 (en) 2021-05-12
CA3050858A1 (en) 2018-08-02
EP4272818A3 (en) 2024-02-14
TW201827074A (zh) 2018-08-01
EP3936140B1 (en) 2023-08-30
AU2018212778A1 (en) 2019-07-11
EP3573635A1 (en) 2019-12-04
JP2020506907A (ja) 2020-03-05
KR20190110095A (ko) 2019-09-27

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Application publication date: 20190906