CN110201082A - 一种鼻炎熏蒸用的中药组合物及其外用制剂 - Google Patents
一种鼻炎熏蒸用的中药组合物及其外用制剂 Download PDFInfo
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Abstract
本发明涉及一种鼻炎熏蒸用的中药组合物,所述中药组合物的原料由以下重量份数组分组成:苍耳子5‑10份,辛夷8‑15份,香附8‑15份,白芷8‑15份,川芎8‑15份,细辛3‑5份,鲜薄荷15‑20份,藿香8‑15份,石菖蒲8‑15份,赤芍8‑15份,枳壳5‑8份,牡丹皮10‑13份,玫瑰花3‑5份。将其先熬制提取成分辅以熏蒸,可根据病情及患者接受程度灵活调节,本发明的中药组合物和现有的相比,显效时间快,治愈率高。
Description
技术领域
本发明属于中药制剂技术领域,涉及一种鼻炎熏蒸用的中药组合物及其外用制剂。
背景技术
随着现代人生活环境污染越来越严重,空气中的雾霾沙尘暴粉尘颗粒日益加剧,雾霾笼罩的区域越来越大,空气中雾霾浓度也越来越高,现在吸进鼻腔肺部里面的除了空气,还有大量空气中的灰尘、硫酸、硝酸等颗粒物组成的气溶胶。雾霾主要由二氧化硫、氮氧化物和可吸入颗粒物这三项组成,前两者为气态污染物,可吸入颗粒物为PM2.5-10,也就是空气动力学当量直径小于等于2.5~10微米的污染物颗粒。这种颗粒本身既是一种污染物,又是重金属、多环芳烃等有毒物质的载体。接触这些各种化学物质及刺激性气体后极大的损伤损害鼻黏膜纤毛功能,所以对于我们无时不在呼吸的鼻子来说,那么最先受创的当然就是直接接触空气的鼻子了,在这种生存环境中,得鼻炎发生率越来越高,长此以往再形成慢性鼻炎。
慢性鼻炎是指患者鼻腔黏膜或黏膜下层的慢性炎症,也是临床上一种常见的多发病,多间歇性鼻塞反复发作,通常以鼻塞、流涕为主要症状,鼻塞可呈间歇性、交替性或持续性,并伴有可伴有少量粘液性或脓涕,嗅觉减退、头昏头痛等。由于慢性鼻炎病情反复、难以治愈且鼻腔分泌物增加,对于患有鼻炎的人来说,真是世界上最折磨人的一种疾病,因为它会影响呼吸和大脑,可能其他的疼痛你都能忍,但是一天24小时呼吸,如果连呼吸都难受,那你还能忍吗?慢性鼻炎随时会发作,得了鼻炎的人每天早上起来都需要清理鼻腔;与朋友或者更正式的场合时,受到刺激性后也会有大量鼻涕流出来,给患者造成十分尴尬的局面;如果遇到冷空气也很容易形成鼻塞;严重的时候会头疼,睡不着觉。反正鼻炎时时刻刻都会给人一种很不爽的感觉,总是影响着人们的生活。长期如此对患者的生理、心理,生活和工作产生一定的不良影响。目前临床治疗措施多以西医为主,包括口服抗感染药物,大部分治疗鼻炎的药物都带有激素成分,或者是抗组胺类药物,其特点是可口服、起效快,能迅速消除鼻、眼和咽喉的症状,但对舒缓鼻塞效果较差。如第—代以扑尔敏为代表药物,因为具有中枢镇静和抗胆碱能作用,易引起困倦、嗜睡、口干等副作用。而且西药都是用的时候鼻子会好一些,不用的时候会很容易复发。中医药治疗本病的手段丰富,包括中药辨证内服,中药外治,如熏鼻、滴鼻、局部注射、雾化吸入、冲洗、贴压穴位及针刺治疗等手段,均具有一定疗效,而采取不同的中药外治手段所对应的中药组分也因“手段”而异,各研发技术人员也在不断探讨各种组方,积极探索更加有效的疗法尤为重要。而在传统的一些熏蒸使用中,是将药物加水煎沸后,熏蒸鼻腔至药液变凉,这将大大使药效打折,煮沸后的蒸汽产生的温度较高,患者忍受不了,待到可忍受的温度,可用于熏蒸的时间短。或者是采用的高温蒸汽熏蒸中药包,高温蒸汽的温度较高,不适合部分特殊的病人使用,比如鼻腔内毛细血管破损的病人,高温水蒸气会使毛细血管扩张,造成鼻腔出血。且采用中药包,药物和水蒸气接触时间短,溶解出的药效成分少。
发明内容
有鉴于此,本发明的目的在于提供一种鼻炎熏蒸用的中药组合物,并提供由该中药组合物制备的外用制剂,有效提取其药物成分,可方便熏蒸以直接作用靶点,并顺鼻腔入肺,走肺经以更好的达到治疗目的。
为达到上述目的,本发明提供如下技术方案:
1.一种鼻炎熏蒸用的中药组合物,所述中药组合物的原料由以下重量份数组分组成:苍耳子5-10份,辛夷8-15份,香附8-15份,白芷8-15份,川芎8-15份,细辛3-5份,鲜薄荷15-20份,藿香8-15份,石菖蒲8-15份,赤芍8-15份,枳壳5-8份,牡丹皮10-13份,玫瑰花3-5份。
进一步,所述中药组合物的原料由以下重量份数组分组成:苍耳子5-8份,辛夷8-12份,香附8-12份,白芷8-12份,川芎8-12份,细辛3-4份,鲜薄荷15-20份,藿香8-12份,石菖蒲8-12份,赤芍8-12份,枳壳5-6份,牡丹皮10-13份,玫瑰花3-5份。
进一步,所述中药组合物的原料由以下重量份数组分组成:苍耳子8份,辛夷10份,香附10份,白芷10份,川芎10份,细辛3份,鲜薄荷15份,藿香10份,石菖蒲10份,赤芍10份,枳壳6份,牡丹皮10份,玫瑰花5份。
2.由以上任意项所述鼻炎熏蒸用的中药组合物制备的外用制剂。
3.一种鼻炎熏蒸用的中药外用制剂,所述外用制剂的制备方法为:
(1)将重量份数的苍耳子5-8份,辛夷8-12份,香附8-12份,白芷8-12份,川芎8-12份,细辛3-4份,藿香8-12份,石菖蒲8-12份,赤芍8-12份,枳壳5-6份,牡丹皮10-13份,玫瑰花3-5份;打粉后加3-5倍水中小火煎煮0.5~1.5小时,再过滤去药渣留药汁,小火熬制,直至约水量的1/15~1/30浓缩体积的药汁;
(2)将鲜薄荷15-20份加10-12倍量水浸泡2-3小时后,用挥发油提取装置加热提取挥发油3-6小时;
(3)再将步骤1)的药液和步骤2)薄荷油混合即可。
进一步,步骤1)的药渣可再加水煎煮提取一次,合并两次的药汁最后一起熬制浓缩。
进一步,步骤3)为将步骤1)的药汁用无菌包装分装保存,步骤2)的薄荷油单独保存,使用前再混合即可。
本发明的有益效果在于:大多数中医认为慢性鼻炎的发病多由正气虚弱,伤风鼻塞反复发作,余邪未清,迁延不愈,邪热伏肺,久蕴不去,致邪热庸结鼻窍而致病。本发明以为鼻通肺气,冷热失调易引发气机不畅,当气滞日久不治,可进而生痰、动火、积留血液,鼻涕虽多但鼻腔干燥,涕中或有血丝,固血气不畅。本发明结合传统的苍耳子、细辛、辛夷、白芷、藿香,配以枳壳,牡丹皮,玫瑰花,枳壳行气,牡丹皮活血、柔肝、祛瘀,玫瑰花不仅气味芳香,长于理气,能入脾肺;故配之既能行散肺气壅遏,又能行气宽中;薄荷味辛,但气温,浮而升,阳气上升。加大薄荷的量,薄荷易挥发,因本发明的组合物是用于鼻炎熏蒸外用,需要一定作用时间,促进各药物更容易透皮吸收。赤芍清热凉血,散瘀止痛,川芎活血而舒筋;石菖蒲气辛性窜,香附也为味苦气辛,二者辅以开窍通气,和理气药佐使用之,气机逆乱得平,腑气得调顺。芳香开窍的药如石菖蒲、冰片、麝香都是,但冰片、麝香芳香易走窜;而石菖蒲则是通过它芳香化湿浊的作用,虽其开窍作用较弱,但还可以起到化痰宣肺的功效,故本方和香附加以合用。本发明通过药物合理配伍,和现有的相比,总有效率都良好在90%以上,但是本发明的中药组合物显效时间快,治愈率高。而且根据本发明所实施的药剂方法,医护者和患者都觉得使用很方便,也易保存。可以先将药物浓缩,再根据病情,患者依从性等不同情况稀释或不稀释进行熏蒸,以达到最后的治疗效果。使用本发明中药组合物制备的外用制剂,患者觉得添加的薄荷油的更好的体验感,使用时顿时神清气爽,鼻塞感觉减轻,熏蒸时是愉悦的,更加加大了患者依从性。
具体实施方式
下面对本发明的优选实施例进行详细的描述。实施例中未注明具体条件的实验方法,通常按照常规条件或按照制造厂商所建议的条件。
实施例1
一种鼻炎熏蒸用的中药组合物:
苍耳子50克,辛夷80克,香附80克,白芷80克,川芎80克,细辛30克,藿香80克,石菖蒲80克,赤芍80克,枳壳50克,牡丹皮100克,玫瑰花30克,鲜薄荷150克。
鼻炎熏蒸用外用制剂的制备方法:
1)将以上原材料除鲜薄荷的其余组分打粉后加3-5倍水中小火煎煮0.5~1.5小时,再过滤去药渣留药汁,小火熬制,直至100-200ml浓缩体积的药汁;
2)将鲜薄荷加10-12倍量水浸泡2-3小时后,用挥发油提取装置加热提取挥发油3-6小时,收油率为1.4~1.6%,也可以直接买市售的薄荷油用。
3)将步骤1)的药液和步骤2)薄荷油混合后可进行熏蒸使用。
步骤1)的药液也可以无菌处理后按10~20ml分装至无菌包装内;使用前再混合步骤2)薄荷油;使用时也可加水稀释后使用。
也可以再加水提取一次,合并2次的煎煮液后再小火熬制浓缩。这样有效将药物成分提出并利用熏蒸直达鼻腔,进一步进入上呼吸道。而且配合熏蒸仪,可方便将药剂的蒸汽温度、速度调节至患者舒适可接受的程度进行使用,加大患者医从性。
也可以按照现有技术将所有原材料加水煎煮提取或者加乙醇进行回流提取后,再加入辅料,制备成颗粒剂,使用时加水溶解后进行熏蒸使用。以上剂量为10次使用量,一天1~2次,视患者鼻炎严重程度使用。
实施例2
一种鼻炎熏蒸用的中药组合物:
苍耳子80克,辛夷100克,香附100克,白芷100克,川芎100克,细辛30克,藿香100克,石菖蒲100克,赤芍100克,枳壳60克,牡丹皮100克,玫瑰花50克,鲜薄荷150克。
制备方法和使用方法同实施例1。
实施例3
一种鼻炎熏蒸用的中药组合物:
苍耳子80克,辛夷120克,香附100克,白芷100克,川芎120克,细辛40克,藿香120克,石菖蒲100克,赤芍100克,枳壳60克,牡丹皮110克,玫瑰花40克,鲜薄荷160克。
制备方法和使用方法同实施例1。
实施例4
一种鼻炎熏蒸用的中药组合物:
苍耳子60克,辛夷130克,香附120克,白芷120克,川芎100克,细辛40克,藿香130克,石菖蒲100克,赤芍120克,枳壳60克,牡丹皮100克,玫瑰花50克,鲜薄荷160克。
制备方法和使用方法同实施例1。
实施例5
一种鼻炎熏蒸用的中药组合物:
苍耳子100克,辛夷150克,香附150克,白芷150克,川芎150克,细辛50克,藿香150克,石菖蒲150克,赤芍150克,枳壳80克,牡丹皮130克,玫瑰花50克,鲜薄荷200克。
制备方法和使用方法同实施例1。
实施例6
选取2018年1月至2019年5月患有鼻炎的自愿者,并告知其情况。
入选标准:
①病程6个月及以上;
②临床表现:间歇性、交替性鼻塞,常伴有头昏头痛以及嗅觉减退等,多涕,黏液性或黏脓性。
③鼻镜检查:鼻黏膜肿胀,下鼻甲肿大,表面光滑,多呈暗红色或淡白色。
④实验室血象检查,白细胞总数不高或略高,中性粒偏高或正常。
⑤鼻窦CT检查无鼻窦炎或仅鼻窦黏膜增厚。
年龄为10-50,其中10-18岁(青少年组)男女各20名,平均年龄13±0.5岁,19-50岁(成人组)男女各30名,平均年龄37±0.3岁。从两组患者从年龄、男女、病程及病情轻重等资料数据进行分析,均无明显差异(P>0.05),分组基本合理。
对照组采用中药雾化吸入法,成分:苍耳子、白芷、辛夷、防风、黄芩、鱼腥草、川芎、桔梗、茯苓、藿香各100g,薄荷、甘草、细辛各30g,将以上药物加水4倍后煎煮1小时,去药渣后提取药液小火熬制500ml左右。
实验组:使用实施例2的中药组合物加水4倍后煎煮1小时,去药渣后提取药液小火熬制500ml左右,薄荷油分别提取存放,使用前再混合。因本实施例是现用,使用时不再稀释,所以未完全浓缩。
熏蒸为每日2次,每次为上述药液50ml。疗程为2周,连续熏蒸6日,休息间隔一日再连续6日。
参照黄选兆、汪吉宝主编《实用耳鼻咽喉科学》对慢性鼻炎的疗效判定标准进行判定。
a、治愈:鼻塞、涕多、头昏、头痛等症完全解除,嗅觉恢复正常,鼻无分泌物,鼻粘膜肿胀消退,下甲体积缩小,鼻腔宽敞。
b、显效:鼻塞等症基本解除,嗅觉部分恢复,鼻分泌物少,鼻粘膜肿胀基本消退,下甲体积缩小,鼻腔宽敞。
c、有效:上述症状和体征较治疗前有所缓解,但尚不稳定。
d、无效:上述症状和体征无改善。
两组实验数据比较如表1所示,实验组的总有效率为98%,对照组的总有效率为94%;其中青少年实验组的治愈率为25%,远远高于青少年对照组10%;成人实验组治愈率为16%,也高于成人对照组8%。根据每人起效时间(觉得鼻塞症状开始有所缓解)统计,青少年实验组的起效时长为2.7±0.95天,显效速度优于青少年对照组4±0.82。成人的起效时长都比青少年的慢,但总体实验组的起效时间短于对照组。
表1两组实验效果比较
所以本发明的中药组合物和现有的相比,总有效率都良好在90%以上,但是本发明的中药组合物显效时间快,治愈率高。而且根据本发明所实施的药剂方法,医护者和患者都觉得使用很方便,也易保存。可以先将药物浓缩,再根据病情,患者依从性等不同情况稀释或不稀释进行熏蒸,以达到最后的治疗效果。使用本发明中药组合物制备的外用制剂,患者觉得添加的薄荷油的更好的体验感,使用时顿时神清气爽,鼻塞感觉减轻,熏蒸时是愉悦的,更加加大了患者依从性。
最后说明的是,以上优选实施例仅用以说明本发明的技术方案而非限制,尽管通过上述优选实施例已经对本发明进行了详细的描述,但本领域技术人员应当理解,可以在形式上和细节上对其作出各种各样的改变,而不偏离本发明权利要求书所限定的范围。
Claims (7)
1.一种鼻炎熏蒸用的中药组合物,其特征在于,所述中药组合物的原料由以下重量份数组分组成:苍耳子5-10份,辛夷8-15份,香附8-15份,白芷8-15份,川芎8-15份,细辛3-5份,鲜薄荷15-20份,藿香8-15份,石菖蒲8-15份,赤芍8-15份,枳壳5-8份,牡丹皮10-13份,玫瑰花3-5份。
2.根据权利要求1所述鼻炎熏蒸用的中药组合物,其特征在于,所述中药组合物的原料由以下重量份数组分组成:苍耳子5-8份,辛夷8-12份,香附8-12份,白芷8-12份,川芎8-12份,细辛3-4份,鲜薄荷15-20份,藿香8-12份,石菖蒲8-12份,赤芍8-12份,枳壳5-6份,牡丹皮10-13份,玫瑰花3-5份。
3.根据权利要求1所述鼻炎熏蒸用的中药组合物,其特征在于,所述中药组合物的原料由以下重量份数组分组成:苍耳子8份,辛夷10份,香附10份,白芷10份,川芎10份,细辛3份,鲜薄荷15份,藿香10份,石菖蒲10份,赤芍10份,枳壳6份,牡丹皮10份,玫瑰花5份。
4.根据权利要求1-3任意项所述鼻炎熏蒸用的中药组合物制备的外用制剂。
5.根据权利要求4所述的外用制剂,其特征在于,所述外用制剂的制备方法为:
(1)将以上原材料除鲜薄荷的其余组分打粉后加3-5倍水中小火煎煮0.5~1.5小时,再过滤去药渣留药汁,小火熬制,直至约水量的1/15~1/30浓缩体积的药汁;
(2)将鲜薄荷加10-12倍量水浸泡2-3小时后,用挥发油提取装置加热提取挥发油3-6小时;
(3)再将步骤1)的药液和步骤2)薄荷油混合即可。
6.根据权利要求5所述的外用制剂,其特征在于,步骤1)的药渣可再加水煎煮提取一次,合并两次的药汁最后一起熬制浓缩。
7.根据权利要求4所述的外用制剂,其特征在于,步骤3)为将步骤1)的药汁用无菌包装分装保存,步骤2)的薄荷油单独保存,使用前再混合即可。
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