CN110193002A - Deer antler extract is with the application in pore refining and/or light spot functional product - Google Patents
Deer antler extract is with the application in pore refining and/or light spot functional product Download PDFInfo
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- CN110193002A CN110193002A CN201910585281.4A CN201910585281A CN110193002A CN 110193002 A CN110193002 A CN 110193002A CN 201910585281 A CN201910585281 A CN 201910585281A CN 110193002 A CN110193002 A CN 110193002A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/32—Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/981—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of mammals or bird
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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Abstract
The invention discloses deer antler extracts with the application in pore refining and/or light spot functional product, belongs to the deep processing technical field of special animals product.The application is that deer antler extract is applied in pore refining and/or light spot functional product as the effective component of pore refining and/or light spot.Deer antler extract is added to and is used to human skin surfaces in cosmetics or drug and can obtain that coarse pore is shunk the effect for becoming smaller and lightening the stain.
Description
Technical field
The present invention relates to deer antler extracts with the application in pore refining and/or light spot functional product, belongs to special type
The deep processing technical field of animal product.
Background technique
Pilose antler refers to the unossified and young horn with fine hair of the stag of sika deer or red deer, is rare medicinal herbs, is known as " dynamic
First of object medicine ".Li Shizhen (1518-1593 A.D.) claims pilose antler " production of sperm mends marrow, blood-nourishing Yiyang, strong muscles and bones in Compendium of Material Medica.Control all deficient, ears
Deaf, mesh is dark, dizziness, empty dysentery." Pharmacopoeia of the People's Republic of China record pilose antler: " invigorating kidney yang, benefiting essence-blood, strengthening the bones and muscles adjust punching to appoint,
Torr sore poison ".Biologically discovery pilose antler be nature uniquely can completely regenerated mammalian organs, be nature growth speed
Spend most fast animal tissue of most fast animal tissue and nature ossification.The function of pilose antler and the biological characteristics of pilose antler and
Ingredient contained by its inside is related.It reports more, but has no about deer antler extract about the effect of pilose antler in the prior art
Report with pore refining and light spot function.
Summary of the invention
Present invention finds the new functions that deer antler extract has pore refining and light spot, the technical solution adopted is as follows:
The present invention provides deer antler extract as pore refining effective component in pore refining functional product
Application.Especially deer antler extract is as the sole active ingredient of pore refining with answering in pore refining functional product
With.
The present invention also provides deer antler extract as light spot effective component with the application in light spot functional product.
Especially deer antler extract is as the sole active ingredient of light spot with the application in light spot functional product.
The present invention also provides deer antler extract, being used as the effective component of pore refining and light spot at the same time has receipts simultaneously
Application in contracting pore and light spot functional product.Especially deer antler extract be used as simultaneously pore refining and light spot it is unique effectively
Ingredient has the application in pore refining and light spot functional product at the same time.
Product of the present invention is cosmetics or drug.The cosmetics are facial mask, face cream, import liquid, skin-moisturizing oil, cream
Liquid, facial cleanser or Essence.
Deer antler extract of the present invention is followed the example of extraction by water extraction, salt water extraction method, zymohydrolysis extracting method, alcohol extracting and is obtained.
Preferably, the deer antler extract passes through following any one method extraction and obtains, and includes the following steps:
Step 1: selection is not peeled the pilose antler of ossification, is cleaned up after removing fine hair；
Step 2: drying after pilose antler is sliced and after crushing or being sliced pilose antler plus water is ground to chyle shape；
Step 3: in by step 2 treated raw material plus water or salt water extract, or to by step 2
In raw material after reason plus water and enzyme carry out enzymolysis, digestion, or alcoholic solution is added in by step 2 treated raw material and is mentioned
It takes；
Step 4: will by step 3, treated that feed liquid is centrifuged, take supernatant；
Step 5: supernatant is dry to get the deer antler extract with pore refining and light spot effect.
Preferably, be sliced in step 2 with a thickness of 0.5mm-3mm.
Preferably, the temperature dried in step 2 is 65 DEG C -80 DEG C, is crushed to 30 mesh~300 mesh.
Preferably, centrifugation described in step 4 is centrifugation 5min~15min at 4000r/min~12000r/min.
Preferably, mode dry described in step 5 is drying, freeze-drying or spray drying.
The invention has the advantages that:
Inventor has found for the first time in the research of many years pilose antler contains the substance for capableing of pore refining and light spot in pilose antler,
It still belongs to the first time in the world, hair papilla cell of the present invention by extracting the extract of acquisition to pilose antler, in vitro culture
After the cell mass of formation, it is found that it has the function of shrinking hair papilla cell group, and be used for human skin surfaces' external application,
It become smaller and lighten the stain it was found that it can shrink coarse pore, suitable for having as pore refining and/or light spot
Effect ingredient is added in cosmetics or drug.
Deer antler extract of the present invention can be extracted and be obtained using water extraction or salt water extraction, alcohol extracting method, and due to pilose antler
It is mainly protein in extract, there are the biggish albumen of molecular weight, therefore can also be by enzymatic isolation method further by larger point
The proteolysis of son amount is easier to be absorbed by the skin in this way at micromolecule polypeptide, and the effect shunk for pore is more preferable.
Pilose antler is China's preciousness Chinese medicine, and safety is without side-effects, and pilose antler is the animal tissue of mammal, with the mankind
Structural constituent is closer to, and application is safe.
Detailed description of the invention
Fig. 1 is the schematic diagram of deer hair and fine hair；Wherein: A is deer hair；B is fine hair.
Fig. 2 is that velvet deerhorn cell is inserted into ware co-culture system schematic diagram in vitro；Wherein: A is to connect deer corium hair papilla cell
Schematic diagram of the kind in the inside culture face of insertion ware semipermeable film；B is that insertion ware is inverted so that velvet deerhorn cell is seeded in this
The schematic diagram in the outside culture face of film；C is the schematic diagram that insertion ware is restored.
Fig. 3 is the formational situation of corium hair papilla cell group in vitro culture；Wherein: A is individually culture；B is to co-culture
System.
Fig. 4 deer antler extract shrinks the pore on nude mice model deerskin.
Specific embodiment
The present invention will be further described combined with specific embodiments below, but the present invention should not be limited by the examples.
Embodiment 1: the discovery of pilose antler pore refining function and the application of the effect
1, the discovery pilose antler of pilose antler biologically may contain the substance of pore refining
The regeneration of pilose antler (at Fig. 1 arrow A) year, can all regenerate from bone knob (from Fig. 1 arrow B) every year.Pilose antler regeneration one
Denier is opened, just along with a unique biological phenomena: the development of pilose antler can will make deerskin (shown in Fig. 1 arrow A) to convert
At fine and soft skin (shown in Fig. 1 arrow B).Skin on bone knob belongs to deerskin, there is thick, long and fine and close deer hair；And on pilose antler
Skin belongs to fine and soft skin, there is very thin, short and abnormal sparse fine hair.Therefore, it is presumed that, hair follicle can be made by containing in pilose antler
It is thinned out, pore attenuates, the substance that hair shaft shortens.
2, velvet deerhorn cell secretion can stimulate the hair papilla cell co-cultured in vitro group to shrink
Respectively in vitro, cells of pilose antler organism and deer dermis of skin hair papilla cell are separated.Corium papilla is thin
Born of the same parents can automatically form cell mass in the case where in vitro culture, and the size of cell mass can represent the size of hair follicle, to reflect
The thickness of hair shaft out.The co-culture system of cells of pilose antler organism and deer dermis of skin two kinds of cells of hair papilla cell is established, this is total
Cultivating system uses cell culture 6 orifice plates to be inserted into ware.In the system, deer corium hair papilla cell is seeded in first slotting
Enter inside culture face (Fig. 2A) of ware semipermeable film；Insertion ware is inverted so that velvet deerhorn cell to be seeded in the outside of the film after 3h
Place 3h in culture face (Fig. 2 B)；Insertion ware is finally restored (Fig. 2 C).
It is thin with pilose antler in co-culture system compared with independent culture is formed by corium hair papilla cell group (Fig. 3 A arrow)
Born of the same parents interact after corium hair papilla cell group (Fig. 3 B arrow) significantly become smaller (P < 0.01).Therefore we it can be concluded that
Conclusion, velvet deerhorn cell secretion can be such that hair papilla cell group shrinks.
3, deer antler extract can shrink the pore of nude mice model skin
The head that deerskin is migrated to nude mice will form fine and soft skin sample skin, however hair is still deer galley proof, and pilose antler is extracted
After object is applied on the skin, pore obviously becomes smaller (at Fig. 4 arrow), and hair shaft attenuates.
4, deer antler extract can make the pore of human face attenuate
Deer antler extract is added in face cream and facial mask, Ms that is coarse to pore, having spot is on probation, tries out 52 in total
Part, receive 45 parts of feedback, 2 parts of place stops using outer because of allergy, has the hair on apparent sense organ using 6 days~9 days feedbacks
The phenomenon that hole attenuates, while also after acne the effect of light spot.
5, the extracting mode of deer antler extract
The extracting method of several deer antler extracts is present embodiments provided below:
(1) water extraction extracts spotted deer antler:
Step 1: selection two thick stick of sika deer is fine and soft or three wooden forks are fine and soft (fresh fine and soft, dry young pilose antler)；
Step 2: burning fine hair using alcohol blast burner, scrub clean, then by pilose antler be sliced (with a thickness of 0.5mm-3mm),
65-80 DEG C of drying is crushed to 30 mesh or more；
Step 3: the 3-10 times of water that pilose antler weight is added in the product that step 2 is obtained carry out soaking at room temperature 24 hours (or
4 DEG C of person are impregnated 72 hours or boiling water and decocted 6 hours)；
Step 4: above-mentioned water extract is subjected to 4000rpm, is centrifuged 10 minutes, takes supernatant；
Step 5: 65 DEG C to 100 DEG C drying, -80 DEG C to -40 DEG C freeze-dryings or spray drying, product are to have receipts
The deer antler extract of contracting pore and light spot effect.
(2) water extraction extracts red deer pilose antler:
Step 1: selection three wooden fork of red deer is fine and soft, four wooden forks are fine and soft or more wooden forks are fine and soft (fresh fine and soft, dry young pilose antler)；
Step 2: burning fine hair using alcohol blast burner, scrub clean, and slice adds appropriate amount of water, colloid mill is ground to chyle
Shape；
Step 3: the 3-10 times of water that weight in pilose antler is added in the product that step 2 is obtained carries out soaking at room temperature 24 hours
(perhaps 4 DEG C impregnate 72 hours or boiling water decoct 6 hours)；
Step 4: above-mentioned water extract is subjected to 4000rpm, is centrifuged 10 minutes, takes supernatant；
Step 5: 65 DEG C to 100 DEG C drying or -80 DEG C to -40 DEG C freeze-dryings or spray drying, product as have receipts
The deer antler extract of contracting pore and light spot effect.
(3) single enzymatic isolation method extracts red deer pilose antler
Step 1: selection three wooden fork of red deer is fine and soft, four wooden forks are fine and soft or more wooden forks are fine and soft (fresh fine and soft, dry young pilose antler)；
Step 2: burning fine hair using alcohol blast burner, scrub clean, then by pilose antler be sliced (with a thickness of 0.5mm-3mm),
65-80 DEG C of drying is crushed to 30 mesh or more；
Step 3: the product that step 2 obtains is added to 3-10 times of water of weight in pilose antler, utilizes pepsin, compound protein
Any one biological enzyme in enzyme, trypsase, neutral proteinase, alkali protease, Collagenase, papain etc. into
Row enzymolysis, digestion, enzymatic hydrolysis condition are as follows: enzyme concentration is the 1/50-1/300 of pilose antler weight, and temperature is 37 DEG C to 55 DEG C, time 2h
To 8h；
Step 4: above-mentioned water extract is subjected to 4000rpm, is centrifuged 10 minutes, takes supernatant；
Step 5: 65 DEG C to 100 DEG C drying or -80 DEG C to -40 DEG C freeze-dryings or spray drying, product as have receipts
The deer antler extract of contracting pore and light spot effect.
(4) double enzymolysis method extracts spotted deer antler
Step 1: selection two thick stick of sika deer is fine and soft or three wooden forks are fine and soft (fresh fine and soft, dry young pilose antler)；
Step 2: burning fine hair using alcohol blast burner, scrub clean, and slice adds appropriate amount of water, colloid mill is ground to chyle
Shape；
Step 3: the product amount of water that step 2 is obtained is 3-10 times of weight in pilose antler, utilizes pepsin, compound
One of protease, trypsase, neutral proteinase, alkali protease, Collagenase, papain etc. biological enzyme into
Row enzymolysis, digestion, the then another biological enzyme of the different type of reselection, while being digested respectively, enzymatic hydrolysis condition
Are as follows: total enzyme concentration is the 1/50-1/300 of pilose antler weight, and temperature is 37 DEG C to 55 DEG C, and the time is 2h to 8h；
Step 4: above-mentioned water extract is subjected to 4000rpm, is centrifuged 10 minutes, takes supernatant；
Step 5: 65 DEG C to 100 DEG C drying or -80 DEG C to -40 DEG C freeze-dryings or spray drying, product as have receipts
The deer antler extract of contracting pore and light spot effect.
(5) multienzyme enzymatic isolation method extracts spotted deer antler
Step 1: selection two thick stick of sika deer is fine and soft or three wooden forks are fine and soft (fresh fine and soft, dry young pilose antler)；
Step 2: burning fine hair using alcohol blast burner, scrub clean, and slice adds appropriate amount of water, colloid mill is ground to chyle
Shape；
Step 3: add water to be 3-10 times of weight in pilose antler the product that step 2 obtains, utilize pepsin, compound egg
Three kinds or three kinds in white enzyme, trypsase, neutral proteinase, alkali protease, Collagenase, papain etc. with
On biological enzyme digested simultaneously or successively respectively, enzymatic hydrolysis condition are as follows: total enzyme concentration is the 1/50-1/300 of pilose antler weight,
Temperature is 37 DEG C to 55 DEG C, and the time is 2h to 8h；
Step 4: above-mentioned water extract is subjected to 4000rpm, is centrifuged 10 minutes, takes supernatant；
Step 5: 65 DEG C to 100 DEG C drying or -80 DEG C to -40 DEG C freeze-dryings or spray drying, product as have receipts
The deer antler extract of contracting pore and light spot effect.
(6) salt water extraction extracts red deer pilose antler:
Step 1: selection three wooden fork of red deer is fine and soft, four wooden forks are fine and soft or more wooden forks are fine and soft (fresh fine and soft, dry young pilose antler)；
Step 2: burning fine hair using alcohol blast burner, scrub clean, and slice is added 3-10 times of pilose antler weight, contains
The salt water of NaCl (concentration 1%), colloid mill are ground to chyle shape；
Step 3: the 3-10 times of water that weight in pilose antler is added in the product that step 2 is obtained carries out soaking at room temperature 24 hours
(perhaps 4 DEG C impregnate 72 hours or boiling water decoct 6 hours)；
Step 4: above-mentioned water extract is subjected to 4000rpm, is centrifuged 10 minutes, takes supernatant；
Step 5: 65 DEG C to 100 DEG C drying or -80 DEG C to -40 DEG C freeze-dryings or spray drying, product as have receipts
The deer antler extract of contracting pore and light spot effect.
(7) alcohol extracting method extracts spotted deer antler:
Step 1: selection two thick stick of sika deer is fine and soft or three wooden forks are fine and soft (fresh fine and soft, dry young pilose antler)；
Step 2: burning fine hair using alcohol blast burner, scrub clean, then by pilose antler be sliced (with a thickness of 0.5mm-3mm),
65-80 DEG C of drying is crushed to 30 mesh or more；
Step 3: it is water-soluble that the ethyl alcohol that 3-10 times of concentration of pilose antler weight is 40% is added in the product that step 2 is obtained
Liquid carries out soaking at room temperature 24 hours (perhaps 4 DEG C impregnate 72 hours or boiling water decocts 6 hours)；
Step 4: above-mentioned water extract is subjected to 4000rpm, is centrifuged 10 minutes, takes supernatant；
Step 5: 65 DEG C to -100 DEG C drying or spray drying, product are to have pore refining and light spot effect
Deer antler extract.
6, influence of the extracting mode of deer antler extract for pore refining
Influence of the deer antler extract for pore refining effect is extracted to investigate zymohydrolysis extracting method and water extraction mode, is carried out
Following experiment:
It is separately cultured deer corium hair papilla cell, condition of culture is 37 DEG C, CO2Concentration is 5%, incubation time 8-10d,
Culture medium is that DMEM adds 10%FBS.It is formed after hair papilla cell group after stablizing, is separately added into the deer of Different Extraction Method extraction
Fine and soft extract observes and measures the size of hair papilla cell group, each group after 3h under the inverted microscope with scale function
Setting 8 parallel, and measurement result is as shown in table 1.As a result illustrate, the deer antler extract that water extraction and enzymatic isolation method obtain can be shunk
Hair papilla cell group, and the contractive effect for the deer antler extract that wherein prepared by enzymatic isolation method is better than pilose antler water and mentions extract.
1. hair papilla cell of table group diameter measurement (unit: μm)
Although the present invention has been disclosed in the preferred embodiment as above, it is not intended to limit the invention, any to be familiar with this
The people of technology can do various changes and modification, therefore protection of the invention without departing from the spirit and scope of the present invention
Range should subject to the definition of the claims.
Claims (10)
1. deer antler extract as pore refining effective component with the application in pore refining functional product.
2. deer antler extract as light spot effective component with the application in light spot functional product.
3. deer antler extract is used as the effective component of pore refining and light spot to have the function of pore refining and light spot at the same time simultaneously
Application in product.
4. application described in claim 1-3 any one, which is characterized in that the product is cosmetics or drug.
5. application according to claim 4, which is characterized in that the cosmetics be facial mask, face cream, import liquid, skin-moisturizing oil,
Lotion, facial cleanser or Essence.
6. application described in claim 1-3 any one, which is characterized in that the deer antler extract passes through water extraction, salt water
Extraction method, zymohydrolysis extracting method, alcohol extracting are followed the example of extraction and are obtained.
7. application according to claim 6, which is characterized in that the deer antler extract is mentioned by any one following method
Acquisition is taken, is included the following steps:
Step 1: selection is not peeled the pilose antler of ossification, is cleaned up after removing fine hair；
Step 2: drying after pilose antler is sliced and after crushing or being sliced pilose antler plus water is ground to chyle shape；
Step 3: in by step 2 treated raw material plus water or salt water extract, or to after step 2 is handled
Raw material in plus water and enzyme carry out enzymolysis, digestion extraction, or alcoholic solution is added in by step 2 treated raw material and is mentioned
It takes；
Step 4: will by step 3, treated that feed liquid is centrifuged, take supernatant；
Step 5: supernatant is dry to get the deer antler extract with pore refining and light spot effect.
8. application according to claim 7, which is characterized in that be sliced in step 2 with a thickness of 0.5mm-3mm；Step 2
The temperature of middle drying is 65 DEG C -80 DEG C, is crushed to 30 mesh~300 mesh.
9. application according to claim 7, which is characterized in that centrifugation is in 4000r/min~12000r/ described in step 4
5min~15min is centrifuged under min.
10. application according to claim 7, which is characterized in that dry mode described in step 5 be drying, freeze-drying or
Spray drying.
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| CN201910585281.4A CN110193002A (en) | 2019-07-01 | 2019-07-01 | Deer antler extract is with the application in pore refining and/or light spot functional product |
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| CN111603431A (en) * | 2020-06-28 | 2020-09-01 | 西安文理学院 | A skin aging resisting emulsion containing cornu Cervi Pantotrichum and its preparation method |
| CN111850075A (en) * | 2020-07-21 | 2020-10-30 | 长春中医药大学 | Cervus elaphus linnaeus soluble protein extract and extraction method and application thereof |
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| CN106344458A (en) * | 2016-10-20 | 2017-01-25 | 吉林农业大学 | Whitening cream containing ginseng and cornu cervi pantotrichum |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN111603431A (en) * | 2020-06-28 | 2020-09-01 | 西安文理学院 | A skin aging resisting emulsion containing cornu Cervi Pantotrichum and its preparation method |
| CN111850075A (en) * | 2020-07-21 | 2020-10-30 | 长春中医药大学 | Cervus elaphus linnaeus soluble protein extract and extraction method and application thereof |
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Application publication date: 20190903 |