CN110172398A - A kind of processing unit - Google Patents
A kind of processing unit Download PDFInfo
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- CN110172398A CN110172398A CN201910580545.7A CN201910580545A CN110172398A CN 110172398 A CN110172398 A CN 110172398A CN 201910580545 A CN201910580545 A CN 201910580545A CN 110172398 A CN110172398 A CN 110172398A
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- crushing block
- processing chamber
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- cutting net
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M45/00—Means for pre-treatment of biological substances
- C12M45/02—Means for pre-treatment of biological substances by mechanical forces; Stirring; Trituration; Comminuting
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
- C12M47/04—Cell isolation or sorting
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Abstract
The embodiment of the invention discloses a kind of processing unit, which includes: processing chamber, the first crushing block, the second crushing block and the first cutting net;Wherein, the first end of processing chamber is arranged in the first crushing block;Second end opposite with first end in processing chamber is arranged in second crushing block;First cutting net, is arranged in the inside of processing chamber at the first crushing block;Wherein, the first crushing block, processing chamber and the second crushing block form encapsulation process chamber;First crushing block and the second crushing block are flexibly connected with processing chamber respectively;First cutting net includes multiple cutting grids.The technical solution of the embodiment of the present invention, it solves and needs artificial participate in when cutting in the prior art to adipose tissue, the technical issues of causing cutting uneven and microbial contamination, realize technical effect efficient to adipose tissue, uniform treatment in an aseptic environment.
Description
Technical field
The present embodiments relate to field of medical technology more particularly to a kind of processing units.
Background technique
Arthritis is a kind of degenerative joint disease for seriously affecting articular cartilage and surrounding tissue, the main table of symptom
Now for arthralgia is stiff, enlargement is powerless and obstacle of taking action, the pain and function in lesion joint are impaired to seriously affect patient's
Daily behavior activity.Traditional treatment method includes using analgestic, the injection of Sodium Hyaluronate lesion etc..
Currently, it includes fat stem cell that vascular mechanism matrix components are isolated in research discovery from adipose tissue, has and divide
The function of cartilage tissue, and self-regeneration energy wired limit of the cartilaginous tissue as vesselless tissue, after impaired, it is therefore desirable to
Fat stem cell improves joint microenvironment to Chondrocyte Differentiation, passes through the adipose tissue microplate section containing ingredients such as stem cells
Transplanting, to perform to repair deficiency joint together and improve the purpose of osteoarticular function.
In the prior art, transplant fat preparation obtain fat stem cell method mainly by adipose tissue either manually or mechanically
The further separation and Extraction such as filter, then be centrifugated after shredding, the adipose tissue process of acquisition is complicated, and function ingredients are lost tight
Weight, cannot reaching the quantity of the tissue repair function stem cell except filling, to adipose tissue to shred degree directly proportional.However, hand
The adipose tissue fragment preparation that work shreds takes time and effort, and the adipose tissue fragment size specification got is inconsistent, causes not
The Stem Cell Activity histocyte got with user in the adipose tissue of processing same size and other effects quantity has differences, and
And the technical issues of processing of adipose tissue is manual operation, increases microbial contamination probability.
Summary of the invention
The embodiment of the present invention provides a kind of processing unit, high to the tissue in processing chamber under sterile environment to realize
Effect, the technical effect of uniform treatment.
The embodiment of the present invention provides a kind of processing unit, the processing unit include: processing chamber, the first crushing block, second squeeze
Briquetting and the first cutting net;Wherein,
First crushing block, is arranged in the first end of the processing chamber;
Second crushing block, is arranged in second end opposite with the first end in the processing chamber;
The first cutting net, is arranged in the inside of the processing chamber at first crushing block;
Wherein, first crushing block, the processing chamber and second crushing block form encapsulation process chamber;Described
One crushing block and second crushing block are flexibly connected with the processing chamber respectively;The first cutting net includes multiple cuttings
Grid.
Further, the processing unit further include:
Second cutting net, is arranged in the inside of the processing chamber at second crushing block;
The second cutting net includes multiple cutting grids;
The aperture of at least one cutting grid in the first cutting net, is greater than at least one of described second cutting net
Cut the aperture of grid.
Further, in the processing unit further include:
Third cuts net, and setting is between the first cutting net and the second cutting net;
Wherein, the third cutting net includes multiple cutting grids, at least one each cutting in the third cutting net
The aperture of grid is greater than at least one grid aperture in the second cutting net.
Further, in the processing unit further include:
The aperture of at least one cutting grid is less than or equal in the first cutting net extremely in the third cutting net
A few grid aperture.
Further, the first end of the processing chamber is provided at least one input interface;The second end of the processing chamber
It is provided at least one output interface;The input interface is three interfaces.
Further, dominant bit of first crushing block relative to the first cutting net is arranged in the input interface
At shifting between the first cutting net;
The output interface is arranged at the maximum displacement that second crushing block is netted relative to second cutting and institute
It states between the second cutting net.
Further, first crushing block and second crushing block, one end away from the processing chamber is respectively set
There is handle.
Further, two handles are connected by rigid material.
Further, finite place piece is respectively set in the first end of the processing chamber and second end, is respectively used to described in limitation
First crushing block and motion range of second crushing block in the processing chamber.
Further, the locating part is detachably connected with the processing chamber.
The technical solution of the embodiment of the present invention, by the way that the first end of processing chamber is arranged in by the first crushing block, second is squeezed
Second end opposite with first end in processing chamber is arranged in block, and the first cutting net, the inside that processing chamber is arranged in is squeezed adjacent to first
At briquetting, wherein the first crushing block, processing chamber and the second crushing block form encapsulation process chamber;First crushing block and second
Crushing block is flexibly connected with processing chamber respectively;First cutting net includes multiple cutting grids, is solved in the prior art to fat
Artificial the technical issues of participating in, causing cutting uneven and microbial contamination is needed when tissue is cut, and is realized in nothing
Technical effect efficient to adipose tissue, uniform treatment under collarium border.
Detailed description of the invention
In order to more clearly illustrate the technical scheme of the exemplary embodiment of the present invention, below to required in description embodiment
The attached drawing to be used does a simple introduction.Obviously, the attached drawing introduced is present invention a part of the embodiment to be described
Attached drawing, rather than whole attached drawings without creative efforts, may be used also for those of ordinary skill in the art
To obtain other attached drawings according to these attached drawings.
Fig. 1 is a kind of structural schematic diagram of processing unit provided by the embodiment of the present invention;
Fig. 2 is a kind of another structural schematic diagram of processing unit provided by the embodiment of the present invention;
Fig. 3 is a kind of another structural schematic diagram of processing unit provided by the embodiment of the present invention;
Fig. 4 is the sectional view of Fig. 3.
Specific embodiment
The present invention is described in further detail with reference to the accompanying drawings and examples.It is understood that this place is retouched
The specific embodiment stated is used only for explaining the present invention rather than limiting the invention.It also should be noted that in order to just
Only the parts related to the present invention are shown in description, attached drawing rather than entire infrastructure.
Embodiment
Fig. 1 is a kind of structural schematic diagram of processing unit provided by the embodiment of the present invention.As shown in Figure 1, the present invention is real
Applying processing unit provided by example includes: processing chamber 110, the first crushing block 120, the second crushing block 130 and the first cutting net
140.The first end 1101 of processing chamber 110 is arranged in first crushing block 120;Second crushing block 130 is arranged in processing chamber 110
The second end 1102 opposite with first end 1101;First cutting net 140, the inside that processing chamber 110 is arranged in are squeezed adjacent to first
At block 120;Wherein, the first crushing block 120, processing chamber 110 and the second crushing block 130 form encapsulation process chamber;First squeezes
Block 120 and the second 130 pieces of extruding are flexibly connected with processing chamber 110 respectively;First cutting net 140 includes multiple cutting grids.
Wherein, processing chamber 110 is the cavity of a sealing.The shape of processing chamber 110 can be cylindrical, cuboid
Deng the shape of processing chamber 110 can be arranged in user according to actual needs.It is in the present embodiment that cylinder is with processing chamber 110
Example is introduced, referring to Fig. 1.
It in the present embodiment, can be using two bottom surfaces of processing chamber as the first end 1101 and second end of processing chamber 110
1102.That is, the first end 1101 of processing chamber 110 is one end of cylindrical bottom;Second end 1102 can be cylinder
The other end of bottom surface, that is, in contrast first end and second end are.
It should be noted that in the present embodiment, it can be using one end of the injected material into processing chamber as first end, object
One end of matter output is as second end.
With continued reference to Fig. 1, the first end 1101 of processing chamber 110 is arranged in the first crushing block 120, and the second crushing block 130 can
To be the second end 1102 that processing chamber 110 is arranged in, it is, of course, also possible to be the of the processing chamber 120 of the first crushing block 120 setting
The first end 1101 of processing chamber 110 is arranged in two ends 1102, the second crushing block 130.Since the first crushing block 120 and second squeezes
The size of briquetting 130, the material of use are all the same, therefore which position of which crushing block setting, no longer limit herein, only
It is necessary to ensure that the first end 1101 of processing chamber 110 and second end 1102 are respectively arranged with the first crushing block 120 and the second crushing block
130, so that processing chamber 110 may be constructed an encapsulation process cavity.Wherein, the first crushing block 120 and the second crushing block
130 can move in processing chamber 110, that is, be flexibly connected with processing chamber 110.
With continued reference to Fig. 1, wherein the first crushing block 120 and the second crushing block 130, the cross of one end of neighbour's processing chamber 110
Sectional area, identical as the floor space of processing chamber 110, thickness can be 2cm, 3cm etc..The one of neighbour's processing chamber 110 in crushing block
End can use rubber material, or the material using one rigidity of rubber material and then setting.The benefit being arranged in this way
It is, the leakproofness of processing chamber can be increased.Far from one end of processing chamber on the first crushing block 120, the second crushing block 130
It is provided with handle 1201.User can control crushing block by handle 1201, and relative displacement occurs in processing chamber 110.
It should be noted that when not placing the first crushing block 120 and the second crushing block 130 in processing chamber 110, processing chamber
110 be the hollow cylinder of no upper bottom surface.
With continued reference to Fig. 1, the first end of processing chamber 110 is further fixedly arranged on the first cutting net 140.First cutting net 140
The first crushing block of neighbour 120.First cutting net 140 can be cylinder, the bottom surface ruler of cross-sectional dimension and processing chamber 110
Very little identical, thickness can be between 1.5 μm to 2 μm, optionally, and 2 μm.It can be made of rigid material.Using rigidity
Material is advantageous in that, can bear certain impact force.It include multiple cutting grids, each cutting on first cutting net 140
Grid all has certain sharpness, can cut the substance being injected into processing chamber 110, optionally, is injected into processing chamber 110
Substance can be fat.The shape of each cutting grid can be quadrangle, hexagon etc. in multiple cutting grids.Each cut
The aperture user for cutting grid can be configured according to actual needs, and optionally, the aperture for cutting grid is 1200 mesh.
Referring to Fig. 1, when user makes the first crushing block 120 towards the direction of the first cutting net 140 by driving handle 1201
When mobile, since the first cutting net 140 using rigid material and has certain sharpness, adipose tissue can be through at least
One cutting mesh segmentation, obtains substance required for user, optionally, fatty microplate section.In the first crushing block 120 towards close
When sealing the movement of processing chamber 110, the second crushing block 130 can be to away from the movement of the direction of processing chamber 110.That is, first squeezes
Briquetting 120, the second crushing block 130 need the activity setting in processing chamber.First cutting net 140 is fixed at processing chamber 110
First end 1101, and at the position of the first crushing block of neighbour 120.When pushing the movement of the first crushing block 120, at least one is cut
Cut the substance that grid can be intracavitary with cutting process.
Substance required for user in order to obtain can also be arranged in processing unit: the second cutting net fixed setting
The second end of processing chamber, i.e., fatty microplate section output end, and the second crushing block of neighbour, referring to fig. 2.Second cutting net 150 is adopted
Material, size are identical as the first cutting net 140, the difference is that: at least one cutting net in the first cutting net 140
The aperture of lattice is greater than at least one of the second cutting net 150 cutting grid aperture.Optionally, in the first cutting net 140 at least
The aperture of one cutting grid is 300 mesh, and the aperture of at least one cutting grid is 1200 mesh in the second cutting net 150.
In order to further ensure that the substance of output interface output is substance needed for user, in the first cutting net 140 and the
It is also provided with third cutting net 160 between two cutting nets 150, is the partial cross-sectional view of Fig. 3 referring to Fig. 3, Fig. 4.Wherein, third is cut
Cutting net 160 also includes multiple cutting grids.Third cuts the aperture of at least one cutting grid in net 160, is greater than the second cutting
The aperture of at least one cutting grid in grid 150.
It may refer to Fig. 3 and Fig. 4, third cutting net 160 is fixed in processing chamber, in the first cutting net 140
Between the second cutting net 150.Third cuts net 160 and also uses rigid material, and cuts grid including at least one, therefore
Cutting process can be carried out to the substance in processing chamber 110.Correspondingly, at least one cutting grid in third cutting net 160
Aperture is less than at least one cutting grid aperture in the first cutting net 140, it can to the object after the first cutting net 140 is cut
Matter is cut again.
Referring to schematic diagram any in Fig. 1-3, based on the above technical solution, in the first end 1101 of processing chamber 110
It is provided at least one input interface 1103, the second end 1102 of processing chamber 110 is provided at least one output interface 1104,
In, input interface 1103 can also be three interfaces.
Wherein, the quantity of at least one input interface 1103 can be one, two or more etc..If an input
Interface 1103, the input interface 1103 can use three interfaces, and one end of the interface is connected with process chambers 110, in addition
Both ends are for injecting other materials, and optionally, one of interface is used to inject the adipose tissue extracted, the injection of another interface
Physiological saline.If the quantity of input interface 1103 has multiple, can be set in any position of processing chamber first end, Mei Gejie
Mouth is respectively used to saline injection and adipose tissue.The quantity of output interface 1104 be also possible to it is multiple, optionally, one.
The output interface 1104 can be exported through processing unit treated substance, can also be other impurity.
Illustratively, can be at different input interfaces 1103, while injecting adipose tissue and physiological saline.Physiology salt
Water can wash away the unwanted impurity of user institute in adipose tissue, and impurity flows out from output interface 1104, until connecing from output
The physiological saline clarification exported at mouth 1104, it is determined that the adipose tissue in processing chamber 110 is what user needed.To processing chamber
Adipose tissue in 110 carries out after handling again, can export from output interface 1104.Wherein, it is handled to adipose tissue
During, output interface 1104 is not communicated with input interface 1103 with the external world.
With further reference to Fig. 3, since the first crushing block 120 and the second crushing block 130 can occur relatively in processing chamber 110
Displacement.When moving in processing chamber 110 in order to avoid crushing block, there are the maximum displacements of the first crushing block 120 to connect lower than input
Mouth 1103, the maximum displacement of the second crushing block 130 are higher than the displacement of output interface 1104, input interface 1103 can be arranged and exist
First crushing block 120 is cut between net 140 relative at the maximum displacement of the first cutting net 140 first, correspondingly, output connects
Mouth 1104 is arranged at the maximum displacement that the second crushing block 130 cuts net 150 relative to second between cutting net.
The first crushing block 120 and the second crushing block 130, the present position in processing chamber 110 are adjusted in order to improve user
A handle can be respectively set away from one end of processing chamber 110 in the first crushing block 120 and the second crushing block 130 in convenience
1201.User can control first crushing block 120 and the second crushing block 130 in processing chamber 110 by handle 1201
Position, referring to figures 1-3.
In order to further increase the convenience for using crushing block, rigid material can be used, by the first crushing block 120 and the
Two crushing blocks 130 are connected away from the respectively arranged handle 1201 in one end of processing chamber 110, as hand-held part 1202.User
It can make the first crushing block 120 being movably arranged in processing chamber 110 and the second crushing block 130 by shaking hand-held part 1202,
It is moved simultaneously towards a direction, so that the substance in processing chamber 110 be made to pass through the first cutting net 140, second cutting net respectively
150 and third cutting net 160 cut and filter, obtain target substance required for user.
Based on the above technical solution, in order to avoid user is when shaking hand-held part 1202,120 He of the first crushing block
The situation that second crushing block 130 is detached from from processing chamber 110 is respectively set limited in the first end and second end of processing chamber 110
Position part.
Wherein, locating part, for ensuring that the first crushing block and the second crushing block move in processing chamber.Locating part can be
Clamp, can be leather sheath, can also be the included clamping part of processing chamber first end certainly.Specifically, can be in processing chamber
A kick is respectively set in first end and second end, cannot when the first crushing block and the second crushing block are moved to the position
Relative displacement occurs again.It is also possible that installing a leather sheath on the outer wall of processing chamber, i.e., it is detachably connected with processing chamber, skin
At least one grid has been put on, crushing block can be made to be difficult to detach from processing chamber.
No matter it should be noted that using any locating part, it is only necessary to be ensured that and shake hand-held part and/or handle
During, the first crushing block and the second crushing block can not be detached from from processing chamber, and specific locating part can not
It limits.
Wherein, in order to avoid to the substance in encapsulation process cavity in the process of processing, it is each to cut net
Breakage is also provided with support frame, is used to support each cutting net.That is, each mating branch being provided with corresponding thereto of cutting net
There is damaged probability to reduce each cutting net in support.
It in the present embodiment, can using the process that processing unit handles the fat being injected into encapsulation process cavity
To be: the fat being drawn into being injected into processing chamber from fatty input interface, while physiological saline being connect from salt water injection
Mouth is injected into processing chamber.Physiological saline washes away the fat being injected into process chambers, removes blood residuals and oil in fat
Rouge, and flowed out from the impurity output interface of impurity treatment chamber second end.From impurity output interface, the physiological saline of outflow
When comparing clarification, then illustrate that the impurity in processing chamber has removed completely, output interface can be closed, and continue from input interface
The physiological saline of predetermined amount is injected, i.e., there are adipose tissues and part physiological saline in processing chamber at this time.Pass through the rolling of hand-held part
It is dynamic that the first crushing block and the second crushing block is made to generate movement in process chambers, to make adipose tissue through the first cutting strainer, the
Two cutting strainers and third cutting strainer cutting.When the adipose tissue in processing chamber is in compact-sized light yellow clear liquid
When to get to predetermined angle is rotated after fatty microplate section, optionally, 180 degree makes fatty microplate section be in fatty microplate section output
Interface opens adipose tissue output interface, adipose tissue is introduced into drainage tube from from output interface.
The technical solution of the embodiment of the present invention, by the way that the first end of processing chamber is arranged in by the first crushing block, second is squeezed
Second end opposite with first end in processing chamber is arranged in block, and the first cutting net, the inside that processing chamber is arranged in is squeezed adjacent to first
At briquetting, wherein the first crushing block, processing chamber and the second crushing block form encapsulation process chamber;First crushing block and second
Crushing block is flexibly connected with processing chamber respectively;First cutting net includes multiple cutting grids, is solved in the prior art to fat
Artificial the technical issues of participating in, causing cutting uneven and microbial contamination is needed when tissue is cut, and is realized in nothing
Technical effect efficient to adipose tissue, uniform treatment under collarium border.
Note that the above is only a better embodiment of the present invention and the applied technical principle.It will be appreciated by those skilled in the art that
The invention is not limited to the specific embodiments described herein, be able to carry out for a person skilled in the art it is various it is apparent variation,
It readjusts and substitutes without departing from protection scope of the present invention.Therefore, although being carried out by above embodiments to the present invention
It is described in further detail, but the present invention is not limited to the above embodiments only, without departing from the inventive concept, also
It may include more other equivalent embodiments, and the scope of the invention is determined by the scope of the appended claims.
Claims (10)
1. a kind of processing unit characterized by comprising processing chamber, the first crushing block, the second crushing block and the first cutting
Net;Wherein,
First crushing block, is arranged in the first end of the processing chamber;
Second crushing block, is arranged in second end opposite with the first end in the processing chamber;
The first cutting net, is arranged in the inside of the processing chamber at first crushing block;
Wherein, first crushing block, the processing chamber and second crushing block form encapsulation process chamber;Described first squeezes
Briquetting and second crushing block are flexibly connected with the processing chamber respectively;The first cutting net includes multiple cutting nets
Lattice.
2. processing unit according to claim 1, which is characterized in that further include:
Second cutting net, is arranged in the inside of the processing chamber at second crushing block;
The second cutting net includes multiple cutting grids;
The aperture of at least one cutting grid in the first cutting net is greater than the cutting of at least one of the second cutting net
The aperture of grid.
3. processing unit according to claim 2, which is characterized in that further include:
Third cuts net, and setting is between the first cutting net and the second cutting net;
Wherein, the third cutting net includes multiple cutting grids, at least one cutting grid in the third cutting net
Aperture, greater than at least one grid aperture in the second cutting net.
4. processing unit according to claim 3, which is characterized in that further include:
The aperture of at least one cutting grid is less than or equal at least one in the first cutting net in the third cutting net
A grid aperture.
5. processing unit according to claim 2, which is characterized in that the first end of the processing chamber is provided at least one
Input interface;The second end of the processing chamber is provided at least one output interface;
The input interface is three interfaces.
6. processing unit according to claim 5, which is characterized in that the input interface is arranged in first crushing block
Between being netted at the maximum displacement of the first cutting net first cutting;
The output interface be arranged in second crushing block relative at the maximum displacement of the second cutting net with described the
Between two cutting nets.
7. processing unit according to claim 1, which is characterized in that first crushing block and second crushing block,
One end away from the processing chamber is respectively arranged with handle.
8. processing unit according to claim 7, which is characterized in that two handles are connected by rigid material.
9. the apparatus according to claim 1, which is characterized in that the first end of the processing chamber is respectively arranged with second end
Locating part is respectively used to limit first crushing block and motion range of second crushing block in the processing chamber.
10. device according to claim 9, which is characterized in that the locating part is detachably connected with the processing chamber.
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US20020188280A1 (en) * | 2001-06-06 | 2002-12-12 | Hien Nguyen | Fat removal device and method |
TW201437363A (en) * | 2013-03-19 | 2014-10-01 | Gwo Xi Stem Cell Applied Technology Co Ltd | Biohomogenizer |
CN106441979A (en) * | 2016-10-20 | 2017-02-22 | 天益健康科学研究院(镇江)有限公司 | Tissue cutting device |
CN206653429U (en) * | 2017-03-21 | 2017-11-21 | 惠州嘉联生物科技开发有限公司 | A kind of fermentation materials conveyer |
CN107904138A (en) * | 2017-11-03 | 2018-04-13 | 浙江工业大学 | The adipose tissue preparation facilities of the component containing vascular stroma is separated from adipose tissue |
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2019
- 2019-06-28 CN CN201910580545.7A patent/CN110172398A/en active Pending
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20020188280A1 (en) * | 2001-06-06 | 2002-12-12 | Hien Nguyen | Fat removal device and method |
TW201437363A (en) * | 2013-03-19 | 2014-10-01 | Gwo Xi Stem Cell Applied Technology Co Ltd | Biohomogenizer |
CN106441979A (en) * | 2016-10-20 | 2017-02-22 | 天益健康科学研究院(镇江)有限公司 | Tissue cutting device |
CN206653429U (en) * | 2017-03-21 | 2017-11-21 | 惠州嘉联生物科技开发有限公司 | A kind of fermentation materials conveyer |
CN107904138A (en) * | 2017-11-03 | 2018-04-13 | 浙江工业大学 | The adipose tissue preparation facilities of the component containing vascular stroma is separated from adipose tissue |
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