CN110157033A - 可用于药物释放的具有强生物适应性石墨烯水凝胶的制备方法 - Google Patents
可用于药物释放的具有强生物适应性石墨烯水凝胶的制备方法 Download PDFInfo
- Publication number
- CN110157033A CN110157033A CN201810112799.1A CN201810112799A CN110157033A CN 110157033 A CN110157033 A CN 110157033A CN 201810112799 A CN201810112799 A CN 201810112799A CN 110157033 A CN110157033 A CN 110157033A
- Authority
- CN
- China
- Prior art keywords
- graphene oxide
- graphene
- hydrogel
- drug release
- hymecromone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/02—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
- C08J3/03—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
- C08J3/075—Macromolecular gels
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J9/00—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof
- C08J9/28—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof by elimination of a liquid phase from a macromolecular composition or article, e.g. drying of coagulum
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2201/00—Foams characterised by the foaming process
- C08J2201/04—Foams characterised by the foaming process characterised by the elimination of a liquid or solid component, e.g. precipitation, leaching out, evaporation
- C08J2201/048—Elimination of a frozen liquid phase
- C08J2201/0482—Elimination of a frozen liquid phase the liquid phase being organic
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2201/00—Foams characterised by the foaming process
- C08J2201/04—Foams characterised by the foaming process characterised by the elimination of a liquid or solid component, e.g. precipitation, leaching out, evaporation
- C08J2201/048—Elimination of a frozen liquid phase
- C08J2201/0484—Elimination of a frozen liquid phase the liquid phase being aqueous
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2305/00—Characterised by the use of polysaccharides or of their derivatives not provided for in groups C08J2301/00 or C08J2303/00
- C08J2305/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2401/00—Characterised by the use of cellulose, modified cellulose or cellulose derivatives
- C08J2401/08—Cellulose derivatives
- C08J2401/26—Cellulose ethers
- C08J2401/28—Alkyl ethers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Dispersion Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- General Chemical & Material Sciences (AREA)
- Materials Engineering (AREA)
- Carbon And Carbon Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
本发明涉及一种可用于药物释放的具有强生物适应性石墨烯水凝胶的制备方法,由氧化石墨烯、壳聚糖衍生物、海藻酸钠、羟甲香豆素、羟乙基纤维素、N,N’‑亚甲基双丙烯酰胺制成,混合液超声处理,水洗、静置脱泡,于‑20℃冻干10小时,室温解冻,重复冷冻解冻过程三次,得水凝胶。本发明的石墨烯水凝胶制备步骤简单,条件温和,具有好的生物相容性、机械性能以及药物控释能力,可用于药物释放领域。
Description
技术领域
本发明属于水凝胶领域,具体涉及一种可用于药物释放的具有强生物适应性石墨烯水凝胶的制备方法。
背景技术
水凝胶是一种新型的功能高分子材料,具有三维网络结构,水溶性或亲水性的聚合物可通过化学方法或物理方法交联形成水凝胶。氧化石墨烯是一种两亲性物质,其亲水亲油性依氧化程度而定。同时它独特的二维结构和超小尺寸(可低至5nm)使其在生物应用上展现了非凡的潜力,如修饰DNA或者控释药等。
运用物理交联的方法可以在温和的条件下制备水凝胶,但物理交联水凝胶稳定性低、机械性能较差。化学交联法制备的水凝胶可以解决上述问题,但大多需要加入一些对细胞和组织有毒/害的引发剂或催化剂。
如果在改性氧化石墨烯上修饰生物相容性分子、靶向分子、响应性分子或聚合物,得到的改性氧化石墨烯在控释药方面有更广泛的应用。
发明内容
本发明的目的在于提供一种可用于药物释放的具有强生物适应性石墨烯水凝胶的制备方法。
本发明解决其技术问题所采用的技术方案是:可用于药物释放的具有强生物适应性石墨烯水凝胶的制备方法,包括以下步骤:
1)将氧化石墨烯分散在去离子水中,常温下超声震荡5-8小时,得浓度5-10wt%的氧化石墨烯分散液;
2)将壳聚糖衍生物、海藻酸钠加入去离子水中,加热溶解2小时得混合液A;
3)将羟甲香豆素加入碱性溶液中溶解得浓度为2-5wt%的羟甲香豆素溶液;
4)将氧化石墨烯分散液和混合液A混匀,然后加入羟乙基纤维素、羟甲香豆素溶液、N,N’-亚甲基双丙烯酰胺,搅拌使各组分均匀分散得混合液B;
5)混合液B超声处理50-100分钟,水洗三次,静置脱泡,于-20℃冻干10小时,室温解冻,重复冷冻解冻过程三次,得水凝胶。
具体地,所述壳聚糖衍生物的加入量为氧化石墨烯质量的5-8%,海藻酸钠加入量为氧化石墨烯质量的2-4%。
具体地,所述壳聚糖衍生物为季铵盐壳聚糖。
具体地,所述羟甲香豆素的加入量为氧化石墨烯质量的3-5%。
具体地,所述步骤3)中碱性溶液为氢氧化钠溶液,浓度为2-4mol/L。
具体地,所述羟乙基纤维素加入量为氧化石墨烯质量的0.5-2%。
具体地,所述N,N’-亚甲基双丙烯酰胺的加入量为氧化石墨烯质量的1-2%。
本发明具有以下有益效果:本发明的石墨烯水凝胶制备步骤简单,条件温和,具有好的生物相容性、机械性能以及药物控释能力,可用于药物释放领域。
具体实施方式
以下是本发明的具体实施例,对本发明的技术方案做进一步描述,但是本发明的保护范围并不限于这些实施例。凡是不背离本发明构思的改变或等同替代均包括在本发明的保护范围之内。
实施例1
可用于药物释放的具有强生物适应性石墨烯水凝胶的制备方法,包括以下步骤:
1)将氧化石墨烯分散在去离子水中,常温下超声震荡7小时,得浓度8wt%的氧化石墨烯分散液;
2)将占氧化石墨烯质量7%的季铵盐壳聚糖、占氧化石墨烯质量3%的海藻酸钠加入去离子水中,加热溶解2小时得混合液A;
3)将占氧化石墨烯质量5%的羟甲香豆素加入4mol/L的氢氧化钠溶液中溶解得浓度为5wt%的羟甲香豆素溶液;
4)将氧化石墨烯分散液和混合液A混匀,然后加入羟乙基纤维素、羟甲香豆素溶液、N,N’-亚甲基双丙烯酰胺,羟乙基纤维素加入量为氧化石墨烯质量的1%,N,N’-亚甲基双丙烯酰胺的加入量为氧化石墨烯质量的1.5%,搅拌使各组分均匀分散得混合液B;
5)混合液B超声处理80分钟,水洗三次,静置脱泡,于-20℃冻干10小时,室温解冻,重复冷冻解冻过程三次,得水凝胶。
实施例2
可用于药物释放的具有强生物适应性石墨烯水凝胶的制备方法,包括以下步骤:
1)将氧化石墨烯分散在去离子水中,常温下超声震荡5小时,得浓度7wt%的氧化石墨烯分散液;
2)将占氧化石墨烯质量5%的季铵盐壳聚糖、占氧化石墨烯质量4%的海藻酸钠加入去离子水中,加热溶解2小时得混合液A;
3)将占氧化石墨烯质量3%的羟甲香豆素加入4mol/L的氢氧化钠溶液中溶解得浓度为2wt%的羟甲香豆素溶液;
4)将氧化石墨烯分散液和混合液A混匀,然后加入羟乙基纤维素、羟甲香豆素溶液、N,N’-亚甲基双丙烯酰胺,羟乙基纤维素加入量为氧化石墨烯质量的1.5%,N,N’-亚甲基双丙烯酰胺的加入量为氧化石墨烯质量的1%,搅拌使各组分均匀分散得混合液B;
5)混合液B超声处理70分钟,水洗三次,静置脱泡,于-20℃冻干10小时,室温解冻,重复冷冻解冻过程三次,得水凝胶。
实施例3
可用于药物释放的具有强生物适应性石墨烯水凝胶的制备方法,包括以下步骤:
1)将氧化石墨烯分散在去离子水中,常温下超声震荡6小时,得浓度10wt%的氧化石墨烯分散液;
2)将占氧化石墨烯质量6%的季铵盐壳聚糖、占氧化石墨烯质量2%的海藻酸钠加入去离子水中,加热溶解2小时得混合液A;
3)将占氧化石墨烯质量4%的羟甲香豆素加入3mol/L的氢氧化钠溶液中溶解得浓度为3wt%的羟甲香豆素溶液;
4)将氧化石墨烯分散液和混合液A混匀,然后加入羟乙基纤维素、羟甲香豆素溶液、N,N’-亚甲基双丙烯酰胺,羟乙基纤维素加入量为氧化石墨烯质量的2%,N,N’-亚甲基双丙烯酰胺的加入量为氧化石墨烯质量的2%,搅拌使各组分均匀分散得混合液B;
5)混合液B超声处理50分钟,水洗三次,静置脱泡,于-20℃冻干10小时,室温解冻,重复冷冻解冻过程三次,得水凝胶。
实施例4
可用于药物释放的具有强生物适应性石墨烯水凝胶的制备方法,包括以下步骤:
1)将氧化石墨烯分散在去离子水中,常温下超声震荡8小时,得浓度5wt%的氧化石墨烯分散液;
2)将占氧化石墨烯质量8%的季铵盐壳聚糖、占氧化石墨烯质量3%的海藻酸钠加入去离子水中,加热溶解2小时得混合液A;
3)将占氧化石墨烯质量5%的羟甲香豆素加入2mol/L的氢氧化钠溶液中溶解得浓度为4wt%的羟甲香豆素溶液;
4)将氧化石墨烯分散液和混合液A混匀,然后加入羟乙基纤维素、羟甲香豆素溶液、N,N’-亚甲基双丙烯酰胺,羟乙基纤维素加入量为氧化石墨烯质量的0.5%,N,N’-亚甲基双丙烯酰胺的加入量为氧化石墨烯质量的2%,搅拌使各组分均匀分散得混合液B;
5)混合液B超声处理100分钟,水洗三次,静置脱泡,于-20℃冻干10小时,室温解冻,重复冷冻解冻过程三次,得水凝胶。
Claims (7)
1.可用于药物释放的具有强生物适应性石墨烯水凝胶的制备方法,其特征在于,包括以下步骤:
1)将氧化石墨烯分散在去离子水中,常温下超声震荡5-8小时,得浓度5-10wt%的氧化石墨烯分散液;
2)将壳聚糖衍生物、海藻酸钠加入去离子水中,加热溶解2小时得混合液A;
3)将羟甲香豆素加入碱性溶液中溶解得浓度为2-5wt%的羟甲香豆素溶液;
4)将氧化石墨烯分散液和混合液A混匀,然后加入羟乙基纤维素、羟甲香豆素溶液、N,N’-亚甲基双丙烯酰胺,搅拌使各组分均匀分散得混合液B;
5)混合液B超声处理50-100分钟,水洗三次,静置脱泡,于-20℃冻干10小时,室温解冻,重复冷冻解冻过程三次,得水凝胶。
2.如权利要求1所述的可用于药物释放的具有强生物适应性石墨烯水凝胶的制备方法,其特征在于,所述壳聚糖衍生物的加入量为氧化石墨烯质量的5-8%,海藻酸钠加入量为氧化石墨烯质量的2-4%。
3.如权利要求1或2所述的可用于药物释放的具有强生物适应性石墨烯水凝胶的制备方法,其特征在于,所述壳聚糖衍生物为季铵盐壳聚糖。
4.如权利要求1所述的可用于药物释放的具有强生物适应性石墨烯水凝胶的制备方法,其特征在于,所述羟甲香豆素的加入量为氧化石墨烯质量的3-5%。
5.如权利要求1所述的可用于药物释放的具有强生物适应性石墨烯水凝胶的制备方法,其特征在于,所述步骤3)中碱性溶液为氢氧化钠溶液,浓度为2-4mol/L。
6.如权利要求1所述的可用于药物释放的具有强生物适应性石墨烯水凝胶的制备方法,其特征在于,所述羟乙基纤维素加入量为氧化石墨烯质量的0.5-2%。
7.如权利要求1所述的可用于药物释放的具有强生物适应性石墨烯水凝胶的制备方法,其特征在于,所述N,N’-亚甲基双丙烯酰胺的加入量为氧化石墨烯质量的1-2%。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201810112799.1A CN110157033A (zh) | 2018-02-05 | 2018-02-05 | 可用于药物释放的具有强生物适应性石墨烯水凝胶的制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201810112799.1A CN110157033A (zh) | 2018-02-05 | 2018-02-05 | 可用于药物释放的具有强生物适应性石墨烯水凝胶的制备方法 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN110157033A true CN110157033A (zh) | 2019-08-23 |
Family
ID=67641000
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201810112799.1A Pending CN110157033A (zh) | 2018-02-05 | 2018-02-05 | 可用于药物释放的具有强生物适应性石墨烯水凝胶的制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN110157033A (zh) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112852003A (zh) * | 2021-03-16 | 2021-05-28 | 浙江大学 | 采用竹笋下脚料制备纤维素/海藻酸钠复合气凝胶的方法、产品及应用 |
CN114605672A (zh) * | 2022-04-12 | 2022-06-10 | 浙江中德生命健康教育研究院 | 一种海藻酸钠-壳聚糖-石墨烯复合水凝胶的制备方法及其应用 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103877953A (zh) * | 2014-03-30 | 2014-06-25 | 河南城建学院 | 一种用于污水处理的水凝胶及其制备方法 |
CN104826128A (zh) * | 2015-04-30 | 2015-08-12 | 中国药科大学 | 生物体病灶部位触发释药的多糖修饰的氧化石墨烯载体及其药学组合物的制备和应用 |
KR20160126208A (ko) * | 2015-04-23 | 2016-11-02 | 광주과학기술원 | 그래핀 기반의 광열화 반응을 이용한 수화겔 제조용 조성물 및 수화겔 제조방법 |
-
2018
- 2018-02-05 CN CN201810112799.1A patent/CN110157033A/zh active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103877953A (zh) * | 2014-03-30 | 2014-06-25 | 河南城建学院 | 一种用于污水处理的水凝胶及其制备方法 |
KR20160126208A (ko) * | 2015-04-23 | 2016-11-02 | 광주과학기술원 | 그래핀 기반의 광열화 반응을 이용한 수화겔 제조용 조성물 및 수화겔 제조방법 |
CN104826128A (zh) * | 2015-04-30 | 2015-08-12 | 中国药科大学 | 生物体病灶部位触发释药的多糖修饰的氧化石墨烯载体及其药学组合物的制备和应用 |
Non-Patent Citations (3)
Title |
---|
王中华: "《油田化学品实用手册》", 31 July 2004 * |
高春梅等: "海藻酸钠水凝胶的制备及其在药物释放中的应用", 《化学进展》 * |
魏太星: "《医生专用药物手册》", 31 January 2015 * |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112852003A (zh) * | 2021-03-16 | 2021-05-28 | 浙江大学 | 采用竹笋下脚料制备纤维素/海藻酸钠复合气凝胶的方法、产品及应用 |
CN112852003B (zh) * | 2021-03-16 | 2022-04-12 | 浙江大学 | 采用竹笋下脚料制备纤维素/海藻酸钠复合气凝胶的方法、产品及应用 |
CN114605672A (zh) * | 2022-04-12 | 2022-06-10 | 浙江中德生命健康教育研究院 | 一种海藻酸钠-壳聚糖-石墨烯复合水凝胶的制备方法及其应用 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Fang et al. | 3D porous chitin sponge with high absorbency, rapid shape recovery, and excellent antibacterial activities for noncompressible wound | |
Zargar et al. | A review on chitin and chitosan polymers: structure, chemistry, solubility, derivatives, and applications | |
Liu et al. | High axial ratio nanochitins for ultrastrong and shape-recoverable hydrogels and cryogels via ice templating | |
Singh et al. | External stimuli response on a novel chitosan hydrogel crosslinked with formaldehyde | |
Peng et al. | Xylan-rich hemicelluloses-graft-acrylic acid ionic hydrogels with rapid responses to pH, salt, and organic solvents | |
KR102204007B1 (ko) | 항균성 및 친수성을 갖춘 분리막 및 그 제조 방법 | |
CN110790885B (zh) | 一种聚乙烯醇/壳聚糖季铵盐抗菌自愈水凝胶及其制备方法和应用 | |
CN106146913B (zh) | 一种壳聚糖基水凝胶及其制备方法和应用 | |
BR112017016072B1 (pt) | Composição, curativo de ferida, e, método de fabricação de uma composição | |
CN110204746B (zh) | 一种交联透明质酸钠凝胶的制备方法 | |
CN106866998A (zh) | 一种壳聚糖季铵盐/羧甲基纤维素超吸水凝胶及其制备方法和应用 | |
El-hefian et al. | Rheological study of chitosan and its blends: An overview | |
BR112017016100B1 (pt) | composição, curativo de ferida, e, método de fabricação de uma composição | |
CN106496357A (zh) | 一种o‑季铵盐‑n‑烷基化壳聚糖及其制备方法与应用 | |
CN111905106A (zh) | 一种缓释型海藻酸钠/壳聚糖/玉米醇溶蛋白复合材料及其制备方法 | |
JPS6320301A (ja) | キトサン微小粒体 | |
CN105085715A (zh) | 一种o-羧甲基壳聚糖的制备方法 | |
CN110157033A (zh) | 可用于药物释放的具有强生物适应性石墨烯水凝胶的制备方法 | |
CN102321255A (zh) | 一种离子型纳米复合水凝胶及其制备方法 | |
CN107141519B (zh) | 一种改性壳聚糖基超吸水凝胶及其制备和应用 | |
CN110157010B (zh) | 一种基于多糖/聚肽的聚电解质复合物水凝胶止血剂 | |
CN107118361B (zh) | 一种丝素蛋白/羧甲基壳聚糖复合凝胶及其制备方法 | |
CN105713106A (zh) | 一种海藻酸钠双交联水凝胶及其制备方法与应用 | |
CN104262880B (zh) | 一种高强度抑菌纳米复合阳离子双网络水凝胶及其制备方法 | |
CN109731133A (zh) | 一种抗菌、抗粘附、可注射式温敏壳聚糖凝胶敷料及其制备方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
RJ01 | Rejection of invention patent application after publication |
Application publication date: 20190823 |
|
RJ01 | Rejection of invention patent application after publication |