CN110156830A - A kind of preparation method of High-purity Phytic Acid - Google Patents
A kind of preparation method of High-purity Phytic Acid Download PDFInfo
- Publication number
- CN110156830A CN110156830A CN201810109883.8A CN201810109883A CN110156830A CN 110156830 A CN110156830 A CN 110156830A CN 201810109883 A CN201810109883 A CN 201810109883A CN 110156830 A CN110156830 A CN 110156830A
- Authority
- CN
- China
- Prior art keywords
- purity
- phytic acid
- mixed liquor
- preparation
- rice bran
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- IMQLKJBTEOYOSI-UHFFFAOYSA-N Phytic acid Natural products OP(O)(=O)OC1C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C1OP(O)(O)=O IMQLKJBTEOYOSI-UHFFFAOYSA-N 0.000 title claims abstract description 29
- IMQLKJBTEOYOSI-GPIVLXJGSA-N Inositol-hexakisphosphate Chemical compound OP(O)(=O)O[C@H]1[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H]1OP(O)(O)=O IMQLKJBTEOYOSI-GPIVLXJGSA-N 0.000 title claims abstract description 28
- 229940068041 phytic acid Drugs 0.000 title claims abstract description 28
- 235000002949 phytic acid Nutrition 0.000 title claims abstract description 28
- 239000000467 phytic acid Substances 0.000 title claims abstract description 28
- 238000002360 preparation method Methods 0.000 title claims abstract description 12
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims abstract description 34
- 241000209094 Oryza Species 0.000 claims abstract description 16
- 235000007164 Oryza sativa Nutrition 0.000 claims abstract description 16
- 235000009566 rice Nutrition 0.000 claims abstract description 16
- 238000000605 extraction Methods 0.000 claims abstract description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 13
- 239000007788 liquid Substances 0.000 claims abstract description 11
- 229920002472 Starch Polymers 0.000 claims abstract description 6
- 238000005342 ion exchange Methods 0.000 claims abstract description 6
- 235000019698 starch Nutrition 0.000 claims abstract description 6
- 239000008107 starch Substances 0.000 claims abstract description 6
- 150000001720 carbohydrates Chemical class 0.000 claims abstract description 5
- 235000014633 carbohydrates Nutrition 0.000 claims abstract description 5
- 238000003756 stirring Methods 0.000 claims abstract description 5
- 239000002253 acid Substances 0.000 claims description 12
- 241000196324 Embryophyta Species 0.000 claims description 9
- 239000003795 chemical substances by application Substances 0.000 claims description 4
- 238000004062 sedimentation Methods 0.000 claims description 4
- 239000000706 filtrate Substances 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 claims description 2
- 238000001914 filtration Methods 0.000 abstract description 4
- 102000004169 proteins and genes Human genes 0.000 abstract description 3
- 108090000623 proteins and genes Proteins 0.000 abstract description 3
- 230000009286 beneficial effect Effects 0.000 abstract description 2
- 239000012535 impurity Substances 0.000 abstract description 2
- 239000000654 additive Substances 0.000 abstract 1
- 230000000996 additive effect Effects 0.000 abstract 1
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 239000011575 calcium Substances 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 240000008042 Zea mays Species 0.000 description 3
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 3
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 3
- 150000001768 cations Chemical class 0.000 description 3
- 235000005822 corn Nutrition 0.000 description 3
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 2
- 239000003513 alkali Substances 0.000 description 2
- 238000005349 anion exchange Methods 0.000 description 2
- 150000001450 anions Chemical class 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- 238000005341 cation exchange Methods 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 239000011777 magnesium Substances 0.000 description 2
- 229910052749 magnesium Inorganic materials 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 238000003825 pressing Methods 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- -1 albumen Substances 0.000 description 1
- 239000003957 anion exchange resin Substances 0.000 description 1
- 239000002956 ash Substances 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000006298 dechlorination reaction Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 229910001415 sodium ion Inorganic materials 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- 238000004065 wastewater treatment Methods 0.000 description 1
- 235000015099 wheat brans Nutrition 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/117—Esters of phosphoric acids with cycloaliphatic alcohols
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
Abstract
The invention discloses a kind of preparation methods of High-purity Phytic Acid, include the following steps, take rice bran and water to be mixed according to a certain percentage, stir evenly；High-purity hydrochloric acid is added into the mixed liquor of rice bran and water, is maintained at the pH value of its mixed liquor in certain value, and mixed liquor is extracted；It is added into the liquid being obtained by extraction for removing removing protein, starch, ash and the additive of carbohydrate, then by liquid by filtering after ion exchange, high-purity hydrochloric acid parsing, and isolated high-purity phytic acid weak solution, it is concentrated into 50% through cryogenic vacuum, both obtains the phytic acid of high-purity, high-quality.The beneficial effects of the present invention are: the phytic acid (phytic acid) extracted is free of any impurity, it is ensured that the high-purity and high-quality of product reach and exceed the high standard quality requirement of pharmaceutical grade health care product.
Description
Technical field
The present invention relates to phytic acid preparation field, the preparation method of specifically a kind of High-purity Phytic Acid.
Background technique
Phytic acid is commonly called as phytic acid, abbreviation IP6.Phytic acid is mainly widely present in the form of calcium and magnesium double salt
In vegetable seeds and plumule, mostly from the plants such as rice bran, corn, wheat bran Hydrolysis kinetics and obtain.Phytic acid, which is that one kind is important, to be had
Machine phosphorus natural has unique physiology, pharmacological function and chemical property, is widely used in food, medicine, daily use chemicals, ring
Numerous industries such as guarantor.
Existing phytic acid extraction process technology is added in limewash and filters pressing, washes from the extract liquors such as rice bran, corn
Wash, acid dissolution, the removing cations such as calcium and magnesium exchanged by cation, then through the yin such as anion exchange removing chlorine root, sulfate radical from
Then son is concentrated into 50% finished product.Or limewash neutralization, filters pressing, acid dissolution decoloration are added from the extract liquors such as rice bran, corn
Filtering, filtrate are parsed through weak-base anion-exchange resin with NaOH, slough Na ion through cation exchange, then through anion
The anion such as dechlorination ion and sulfate radical are exchanged, 50% finished product is then concentrated into.Since there are two big defects for above-mentioned technique: one
It is that extract liquor is neutralized through the equal alkalinity of Ca (OH) 2, wastes a large amount of acid (hydrochloric acid or acetic acid when extraction etc.) and alkali Ca (OH) 2
Or NaOH.Second is that: pass through cation and anion exchange respectively, complex operation, regeneration and cleaning need to consume a large amount of acid, alkali and
Deionized water brings great treating capacity and processing cost to rear road wastewater treatment.Third is that: technical process is too long, seriously affects
Product Activity and quality, it is difficult to produce high-quality phytic acid.
Summary of the invention
The purpose of the present invention is to provide a kind of preparation methods of High-purity Phytic Acid, to solve to propose in above-mentioned background technique
The problem of.
To achieve the above object, the invention provides the following technical scheme:
A kind of preparation method of High-purity Phytic Acid, comprising the following steps:
A1. it takes rice bran and water to be mixed by a certain percentage, stirs evenly；
A2. high-purity hydrochloric acid is added into the mixed liquor of rice bran and water, is maintained at the pH value of its mixed liquor in certain value,
And mixed liquor is extracted；
A3. the sedimentation agent of deproteinized, starch, ash content and carbohydrate is added into the liquid being obtained by extraction, then filters, will filter
Liquid is parsed through ion exchange with high-purity hydrochloric acid, the diluted plant acid solution of parsing, after separating hydrochloric acid, is concentrated into 50% i.e. high-quality
Phytic acid.
As a further solution of the present invention: the ratio of rice bran and water is 1:9 or 1:10 in step A1.
As a further solution of the present invention: the pH value of mixed liquor is 1.8~2.2 in step A2.
As a further solution of the present invention: the time extracted in step A2 to mixed liquor is 4~8 hours, extraction
Temperature is (10~20 DEG C) 8 hours, and extraction temperature is (21~30 DEG C) 4 hours.
As further scheme of the invention: it is 5.6 to 3.4 that high-purity hydrochloric acid deal ratio is used in step A3.
Compared with prior art, it the beneficial effects of the present invention are: extracting plant acid solution from rice bran, removes first soluble
Impurity such as albumen, starch, ash, polysaccharide, then obtain diluted plant acid solution through ion exchange, then after hydrochloric acid is separated, carry out dense
It is reduced to 50%, to obtain high-quality phytic acid, reaches the high standard quality requirement of Medicines and Health Product.
Specific embodiment
Based on the embodiments of the present invention, those of ordinary skill in the art are obtained without making creative work
The every other embodiment obtained, shall fall within the protection scope of the present invention.
Embodiment 1
A kind of High-purity Phytic Acid extracting method, includes the following steps,
A1 takes rice bran and water to be mixed according to the ratio of 1:9, stirs evenly；
A2 makes the PH 1.8~2.2 of its mixed liquor to high-purity hydrochloric acid is added in the mixed liquor of rice bran and water, and will mix
It closes liquid and carries out extraction 4~8 hours；
A3 is added into the liquid being obtained by extraction for removing removing protein, starch, ash content and the sedimentation agent of carbohydrate, then liquid
Body obtains diluted plant acid solution by filtering and ion exchange, resolving hydrochloric acid, and separation hydrochloric acid is concentrated into 50%, obtains high-quality plant
Acid.
Embodiment 2
A kind of extracting method of high-purity phytic acid (phytic acid), comprising the following steps:
A1 takes rice bran and water to be mixed according to the ratio of 1:10, stirs evenly；
A2 makes the PH 1.8~2.2 of its mixed liquor to high-purity hydrochloric acid is added in the mixed liquor of rice bran and water, and will mix
It closes liquid and carries out extraction 4~8 hours；
A3 is added into the liquid being obtained by extraction for removing removing protein, starch, ash content and the sedimentation agent of carbohydrate, then liquid
Body obtains diluted plant acid solution by filtering and ion exchange, resolving hydrochloric acid, and separation hydrochloric acid is concentrated into 50%, obtains high-quality plant
Acid.
It is obvious to a person skilled in the art that invention is not limited to the details of the above exemplary embodiments, Er Qie
In the case where without departing substantially from spirit or essential attributes of the invention, the present invention can be realized in other specific forms.Therefore, no matter
From the point of view of which point, the present embodiments are to be considered as illustrative and not restrictive, and the scope of the present invention is by appended power
Benefit requires rather than above description limits, it is intended that all by what is fallen within the meaning and scope of the equivalent elements of the claims
Variation is included within the present invention.
In addition, it should be understood that although this specification is described in terms of embodiments, but not each embodiment is only wrapped
Containing an independent technical solution, this description of the specification is merely for the sake of clarity, and those skilled in the art should
It considers the specification as a whole, the technical solutions in the various embodiments may also be suitably combined, forms those skilled in the art
The other embodiments being understood that.
Claims (5)
1. a kind of preparation method of High-purity Phytic Acid, which comprises the following steps:
A1. it takes rice bran and water to be mixed by a certain percentage, stirs evenly；
A2. high-purity hydrochloric acid is added into the mixed liquor of rice bran and water, is maintained at the pH value of its mixed liquor in certain value, and will
Mixed liquor is extracted；
A3. the sedimentation agent of deproteinized, starch, ash content and carbohydrate is added into the liquid being obtained by extraction, then filters, filtrate is passed through
Ion exchange is parsed with high-purity hydrochloric acid, the diluted plant acid solution of parsing, after separating hydrochloric acid, is concentrated into 50% i.e. high-quality phytic acid.
2. the preparation method of High-purity Phytic Acid according to claim 1, which is characterized in that the ratio of rice bran and water in step A1
Example is 1:9 or 1:10.
3. the preparation method of High-purity Phytic Acid according to claim 1, which is characterized in that the pH value of mixed liquor in step A2
It is 1.8 ~ 2.2.
4. the preparation method of High-purity Phytic Acid according to claim 1, which is characterized in that carried out in step A2 to mixed liquor
The time of extraction is 4 ~ 8 hours, and extraction temperature is (10 ~ 20 DEG C) 8 hours, and extraction temperature is (21 ~ 30 DEG C) 4 hours.
5. the preparation method of High-purity Phytic Acid according to claim 1, which is characterized in that use high purity salt in step A3
Sour deal ratio is 5.6 to 3.4.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810109883.8A CN110156830A (en) | 2018-02-05 | 2018-02-05 | A kind of preparation method of High-purity Phytic Acid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810109883.8A CN110156830A (en) | 2018-02-05 | 2018-02-05 | A kind of preparation method of High-purity Phytic Acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110156830A true CN110156830A (en) | 2019-08-23 |
Family
ID=67641309
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810109883.8A Withdrawn CN110156830A (en) | 2018-02-05 | 2018-02-05 | A kind of preparation method of High-purity Phytic Acid |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110156830A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114369116A (en) * | 2021-12-22 | 2022-04-19 | 厦门世达膜科技有限公司 | Method for extracting high-purity phytic acid |
-
2018
- 2018-02-05 CN CN201810109883.8A patent/CN110156830A/en not_active Withdrawn
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114369116A (en) * | 2021-12-22 | 2022-04-19 | 厦门世达膜科技有限公司 | Method for extracting high-purity phytic acid |
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| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication | ||
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Application publication date: 20190823 |