CN110152749A - A kind of preparation method of high polymer micro-flow control chips - Google Patents
A kind of preparation method of high polymer micro-flow control chips Download PDFInfo
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- CN110152749A CN110152749A CN201910526722.3A CN201910526722A CN110152749A CN 110152749 A CN110152749 A CN 110152749A CN 201910526722 A CN201910526722 A CN 201910526722A CN 110152749 A CN110152749 A CN 110152749A
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- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
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Abstract
The invention discloses a kind of preparation methods of high polymer micro-flow control chips, it include: to utilize near field electrostatic spinning direct-write process orientated deposition spinning fibre in the first substrate, and the first control piece in hollow structure is trapped among the periphery of spinning fibre and is fixed in the first substrate, to obtain upper mold；Shape and size the second control piece identical with the first control piece are fixed in the second substrate, to obtain lower mold；High polymer micro-flow control chips are prepared using preconfigured liquid high polymer, upper mold and lower mold.Above-mentioned technical proposal disclosed in the present application can reduce the preparation cost of high polymer micro-flow control chips and the complexity of preparation using near field electrostatic spinning direct-write process, and the preparation precision of microchannel can be improved.
Description
Technical field
The present invention relates to micro fluidic chip technical fields, more specifically to a kind of system of high polymer micro-flow control chips
Preparation Method.
Background technique
Microfluidic chip technology is bases such as biology, chemistry, the sample preparation of medical analysis process, reaction, separation, detections
This operating unit is integrated on the chip of one piece of micro-meter scale, is automatically performed analysis overall process.
Currently, when preparing high polymer micro-flow control chips by method of molding, need to first pass through laser engraving or photoetching and
The mode of etching prepares template, then, template, high polymer material is recycled to prepare micro-fluidic chip.But laser engraving
Cost is relatively high, and the requirement especially when the size of template reaches micron dimension to laser equipment can be higher, correspondingly, laser
The cost of equipment can be higher, therefore, then can further increase the preparation cost of micro-fluidic chip, and the technique of photoetching and etching ratio
It is more complex and relatively low using the Line-width precision of template prepared by photoetching and etch process, therefore, then it can reduce miniflow
Control the precision of microchannel in chip.
In conclusion how to reduce the preparation cost of high polymer micro-flow control chips and the complexity of preparation, and improve micro-
The preparation precision in channel is current those skilled in the art technical problem urgently to be resolved.
Summary of the invention
In view of this, the object of the present invention is to provide a kind of preparation method of high polymer micro-flow control chips, it is high poly- to reduce
The preparation cost of object micro-fluidic chip and the complexity of preparation, and improve the preparation precision of microchannel.
To achieve the goals above, the invention provides the following technical scheme:
A kind of preparation method of high polymer micro-flow control chips, comprising:
Using near field electrostatic spinning direct-write process in the first substrate orientated deposition spinning fibre, and will be in hollow structure
First control piece is trapped among the periphery of the spinning fibre and is fixed in first substrate, to obtain upper mold；
Shape and size the second control piece identical with first control piece are fixed in the second substrate, to obtain
Lower mold；
Liquid high polymer is configured, and is prepared into using the liquid high polymer, the upper mold and the lower mold
To high polymer micro-flow control chips.
Preferably, it, in orientated deposition spinning fibre in the first substrate, is also wrapped using near field electrostatic spinning direct-write process
It includes:
The stacking number of the spinning fibre is controlled.
Preferably, using near field electrostatic spinning direct-write process in the first substrate orientated deposition spinning fibre, comprising:
Using near field electrostatic spinning direct-write process in first substrate orientated deposition nanofiber.
Preferably, the stacking number of the spinning fibre is controlled, comprising:
It controls to obtain the stacked structure of cross section semicircular in shape or half elliptic by stacking number.
Preferably, the first control piece in hollow structure is being trapped among the periphery of the spinning fibre and is being fixed on described
After in one substrate, further includes:
First substrate is placed in vacuum oven and is pre-processed.
Preferably, that high polymer is prepared using the liquid high polymer, the upper mold and the lower mold is micro-
Fluidic chip, comprising:
The liquid high polymer is cast in respectively in upper mold and in the lower mold, and is solidified, with right
It should obtain the upper layer high polymer micro-flow control chips with preset thickness and lower layer's high polymer micro-flow control chips, wherein the upper layer
There is microchannel corresponding with the spinning fibre on high polymer micro-flow control chips；
The mode being by mechanically pulling off strips down the upper layer high polymer micro-flow control chips from the upper mold,
And the mode being by mechanically pulling off strips down lower layer's high polymer micro-flow control chips from the lower mold；
It is punched at the endpoint location of the microchannel, and described micro- by having on the upper layer high polymer micro-flow control chips
The one side in channel fits together with lower layer's high polymer micro-flow control chips, to obtain the high polymer micro-flow control chips.
Preferably, high in the one side and the lower layer that will there is the microchannel on the upper layer high polymer micro-flow control chips
Before polymers micro-fluidic chip fits together, further includes:
The upper layer high polymer micro-flow control chips and lower layer's high polymer micro-flow control chips are cleaned by ultrasonic.
Preferably, high in the one side and the lower layer that will there is the microchannel on the upper layer high polymer micro-flow control chips
After polymers micro-fluidic chip fits together, further includes:
To the upper layer high polymer micro-flow control chips and the lower layer's high polymer micro-flow control chips progress heat of fitting together
Pressure processing.
Preferably, liquid high polymer is configured, comprising:
PDMS performed polymer is prepared using PDMS monomer and curing agent, and the PDMS performed polymer is vacuumized.
Preferably, using near field electrostatic spinning direct-write process in the first substrate orientated deposition spinning fibre, comprising:
The high polymer of preset value is higher by as near field electrostatic spinning direct-write process using the solidification temperature of fusing point ratio PDMS
Spinning material, and utilize spinning material spinning fibre described in orientated deposition in first substrate.
The present invention provides a kind of preparation methods of high polymer micro-flow control chips, comprising: utilizes near field electrostatic spinning direct write
Technique orientated deposition spinning fibre in the first substrate, and the first control piece in hollow structure is trapped among to the periphery of spinning fibre
And be fixed in the first substrate, to obtain upper mold；By shape and size the second control piece identical with the first control piece
It is fixed in the second substrate, to obtain lower mold；Configure liquid high polymer, and using liquid high polymer, upper mold and under
High polymer micro-flow control chips are prepared in layer mold.
Above-mentioned technical proposal disclosed in the present application, by near field electrostatic spinning direct-write process orientated deposition spinning fibre, and
Upper mold is obtained by the first control piece, is obtained down by second control piece all the same with the first control piece size and shape
Layer mold, and high polymer micro-flow control chips are prepared using upper mold, lower mold and configured liquid high polymer.Due to
Near field electrostatic spinning direct-write process can directly orientated deposition spinning fibre to obtain the pattern in upper mold, therefore, then may be used
To reduce the complexity of mold preparation, to reduce the complexity of high polymer micro-flow control chips preparation, and due to passing through
Therefore it is micro- that high polymer then can be improved in the relatively high spinning fibre of the available Line-width precision of near field electrostatic spinning direct-write process
The precision of microchannel in fluidic chip, in addition, due near field electrostatic spinning direct-write process without cost it is higher swash
Light device can efficiently prepare the upper mold of micron dimension, therefore, then can reduce the preparation cost of upper mold, from
And the preparation cost of high polymer micro-flow control chips can be reduced.
Detailed description of the invention
In order to more clearly explain the embodiment of the invention or the technical proposal in the existing technology, to embodiment or will show below
There is attached drawing needed in technical description to be briefly described, it should be apparent that, the accompanying drawings in the following description is only this
The embodiment of invention for those of ordinary skill in the art without creative efforts, can also basis
The attached drawing of offer obtains other attached drawings.
Fig. 1 is a kind of flow chart of the preparation method of high polymer micro-flow control chips provided in an embodiment of the present invention；
Fig. 2 is the schematic diagram provided in an embodiment of the present invention that spinning fibre is deposited using near field electrostatic spinning direct-write process；
Fig. 3 is the structural schematic diagram of upper layer high polymer micro-flow control chips provided in an embodiment of the present invention.
Specific embodiment
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete
Site preparation description, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.It is based on
Embodiment in the present invention, it is obtained by those of ordinary skill in the art without making creative efforts every other
Embodiment shall fall within the protection scope of the present invention.
Referring to Fig. 1, it illustrates a kind of streams of the preparation method of high polymer micro-flow control chips provided in an embodiment of the present invention
Cheng Tu may include:
S11: near field electrostatic spinning direct-write process orientated deposition spinning fibre in the first substrate is utilized, and will be in hollow knot
First control piece of structure is trapped among the periphery of spinning fibre and is fixed in the first substrate, to obtain upper mold.
Selected first substrate, and select high polymer material as the spinning material of near field electrostatic spinning direct-write process, then,
Using near field electrostatic spinning direct-write process in the first substrate orientated deposition spinning fibre.Wherein, the spinning fibre deposited is used
In it is subsequent prepare high polymer micro-flow control chips during form microchannel, orientated deposition is according to being prepared
The pattern (i.e. the distribution of microchannel and style etc.) of microchannel in high polymer micro-flow control chips and carry out deposition, finally may be used
To prepare spinning fibre corresponding with the pattern of microchannel, that is to say, that use near field electrostatic spinning direct-write process can be with
Directly, simply, the easily pattern in custom mold therefore can then reduce the fussy degree of upper mold preparation, in reduction
The preparation difficulty of layer mold, improves the preparation efficiency of upper mold.
Specifically it may refer to Fig. 2, it is heavy using near field electrostatic spinning direct-write process that it illustrates provided in an embodiment of the present invention
The schematic diagram of product spinning fibre, using spray head 1, orientated deposition goes out spinning fibre 3 in the first substrate 2.Wherein, near-field electrostatic is spun
The basic principle of silk direct-write process are as follows: spun by reducing spinning distance (i.e. the distance between spray head 1 and the first substrate 2) to reduce
Filament voltage (spinning distance can control in 20mm hereinafter, spinning voltage can be 1kV-4kV), while (being herein by collecting board
For the first substrate 2) it is placed on two-dimension moving platform, the motion path by controlling two-dimension moving platform realizes spinning fibre two
Orientated deposition in dimensional plane.
After orientated deposition goes out spinning fibre in the first substrate, then the first control piece in hollow structure can be trapped among
The periphery of spinning fibre, and the first control piece can be fixed in the first substrate, to obtain being used to prepare upper layer high polymer
The upper mold of micro-fluidic chip.Wherein, the shape and size of the first control piece in hollow structure can be respectively according to being wanted
The shape and size for the high polymer micro-flow control chips being prepared are set, and are used to play the role of assist formation, to prevent
Liquid high polymer only occurs when preparing upper layer high polymer micro-flow control chips using upper mold and the liquid high polymer configured
Random flowing, to play the role of control to the shape of upper layer high polymer micro-flow control chips.Furthermore it is possible to be controlled using aluminium
Part as the first control piece, such as: if finally to prepare the high polymer micro-flow control chips of structure annular in shape, aluminium can be used
Ring is as the first control piece.
Since the preparation of upper mold need to only be controlled by equipment relevant near field electrostatic spinning direct-write process and first
Product can be realized, and due to can more efficiently prepare the upper of micron-scale by near field electrostatic spinning direct-write process
Therefore layer mold can then reduce the preparation cost of upper mold, so as to reduce upper layer high polymer micro-flow control chips and height
The preparation cost of polymers micro-fluidic chip.
S12: shape and size the second control piece identical with the first control piece are fixed in the second substrate, to obtain
Lower mold.
Selected second substrate, and shape and size the second control piece identical with the first control piece are fixed on the second base
On bottom, to obtain being used to prepare the lower mold of lower layer's high polymer micro-flow control chips.Wherein, the second control piece can equally play
The effect of assist formation, to prevent from preparing lower layer's high polymer micro-flow control core using lower mold and the liquid high polymer configured
The random flowing that liquid high polymer occurs when piece, to play the role of control to the shape of lower layer's high polymer micro-flow control chips.
In addition, making shape, the size of the shape of the second control piece, size and the first control piece are identical respectively can obtain shape in order to subsequent
The upper layer high polymer micro-flow control chips and lower layer's high polymer micro-flow control chips that shape and size uniformity cause, in order to which upper layer high polymer is micro-
It can be bonded completely between fluidic chip and lower layer's high polymer micro-flow control chips.
Since the preparation of lower mold only needs to can be completed by the second substrate and the second control piece, then it can be with
Reduce the preparation cost of lower mold.In addition, since the preparation of lower layer's mould group only needs the second control piece being fixed on the second base
It can be obtained on bottom, therefore, preparation process is fairly simple, convenient.
S13: liquid high polymer is first configured, and high gather is prepared using liquid high polymer, upper mold and lower mold
Object micro-fluidic chip.
After upper mold and lower mold is prepared, liquid high polymer can be configured, it is then possible to utilize liquid
High polymer and upper mold are obtaining upper layer high polymer micro flow chip after solidification, and can use liquid high polymer under
Layer mold is obtaining lower layer's high polymer micro-flow control chips after solidification, wherein obtained upper layer high polymer micro-flow control core
On piece has microchannel corresponding with spinning fibre.It, can be in upper layer Gao Ju after obtaining upper layer high polymer micro-flow control chips
It is punched at the microchannel endpoint of object micro-fluidic chip, to obtain sample holes and sample outlet hole, referring specifically to Fig. 3, it illustrates this hairs
The structural schematic diagram for the upper layer high polymer micro-flow control chips that bright embodiment provides, wherein the hole 5 at 4 endpoint of microchannel
It can be used as sample holes, sample outlet hole uses.
It, then can be by upper layer high polymer after obtaining upper layer high polymer micro flow chip and lower layer's high polymer micro-flow control chips
Micro-fluidic chip and lower layer's high polymer micro-flow control chips fit together, to obtain high polymer micro-flow control chips.In upper layer Gao Ju
When object micro-fluidic chip and lower layer's high polymer micro-flow control chips are bonded, need there is upper layer high polymer micro-flow control chips microchannel
One side fit together with lower layer high polymer micro-flow control chips, it is closed micro- to be formed using lower layer's high polymer micro-flow control chips
Channel.
Since the relatively high spinning fibre of Line-width precision can be prepared using near field electrostatic spinning direct-write process,
The relatively high microchannel of final then available Line-width precision, so as to improve prepared high polymer micro-flow control chips
Quality.In addition, due to can finally prepare relatively smooth microchannel using near field electrostatic spinning direct-write process, then
Microchannel interior walls can be reduced to the resistance and skin effect of fluid, so that flow velocity of the fluid in microchannel then can be improved,
It improves fluid and enters sample speed and out sample speed, reduce into the sample time and sample time out, and then the test sample time can be shortened, raising
Test sample efficiency.
Above-mentioned technical proposal disclosed in the present application, by near field electrostatic spinning direct-write process orientated deposition spinning fibre, and
Upper mold is obtained by the first control piece, is obtained down by second control piece all the same with the first control piece size and shape
Layer mold, and high polymer micro-flow control chips are prepared using upper mold, lower mold and configured liquid high polymer.Due to
Near field electrostatic spinning direct-write process can directly orientated deposition spinning fibre to obtain the pattern in upper mold, therefore, then may be used
To reduce the complexity of mold preparation, to reduce the complexity of high polymer micro-flow control chips preparation, and due to passing through
Therefore it is micro- that high polymer then can be improved in the relatively high spinning fibre of the available Line-width precision of near field electrostatic spinning direct-write process
The precision of microchannel in fluidic chip, in addition, due near field electrostatic spinning direct-write process without cost it is higher swash
Light device can efficiently prepare the upper mold of micron dimension, therefore, then can reduce the preparation cost of upper mold, from
And the preparation cost of high polymer micro-flow control chips can be reduced.
The preparation method of a kind of high polymer micro-flow control chips provided in an embodiment of the present invention, straight using near field electrostatic spinning
Technique is write in orientated deposition spinning fibre in the first substrate, can also include:
The stacking number of spinning fibre is controlled.
Near field electrostatic spinning direct-write process is being utilized in orientated deposition spinning fibre in the first substrate, it can be to spinning fibre
The stacking number of dimension is controlled and (can specifically be controlled by controlling the number of orientated deposition stacking number)
To control the height of spinning fibre along the longitudinal direction, in order to which the microchannel of high-aspect-ratio may finally be obtained, to improve most
The performance of high polymer micro-flow control chips prepared by end.
A kind of preparation method of high polymer micro-flow control chips provided in an embodiment of the present invention, utilizes near field electrostatic spinning direct write
Technique orientated deposition spinning fibre in the first substrate may include:
Using near field electrostatic spinning direct-write process in the first substrate orientated deposition nanofiber.
When using near field electrostatic spinning direct-write process orientated deposition spinning fibre, can with orientated deposition nanofibers,
Diameter can be obtained in the spinning fibre of nanometer scale, so that correspondence obtains the microchannel of nanometer scale, consequently facilitating improving
The depth-to-width ratio of final prepared microchannel, and convenient for obtaining the higher high polymer micro-flow control chips of mass ratio.
In addition, using near field electrostatic spinning direct-write process preparation nanometer scale spinning fibre cost is relatively low, efficiency
It is relatively high and relatively convenient, therefore, then the preparation cost and complexity of the microchannel of nanometer scale can be reduced, and can
To improve the preparation efficiency of the microchannel of nanometer scale.
The preparation method of a kind of high polymer micro-flow control chips provided in an embodiment of the present invention, to the stacking number of spinning fibre
It is controlled, may include:
It controls to obtain the stacked structure of cross section semicircular in shape or half elliptic by stacking number.
When the stacking number to spinning fibre controls, cross section can be prepared by stacking number is in
Semicircle or half elliptic stacked structure, to finally obtain the microchannel of cross section semicircular in shape or half elliptic.
For existing rectangular channel, in the identical situation of cross-sectional area, cross section semicircular in shape or half ellipse
The contact area of circular microchannel and fluid is smaller, therefore, then can reduce microchannel interior walls to the resistance and table of fluid
Face effect improves test sample efficiency so as to improve flow velocity of the fluid in microchannel.
The preparation method of a kind of high polymer micro-flow control chips provided in an embodiment of the present invention, by hollow structure first
After control piece is trapped among the periphery of spinning fibre and is fixed in the first substrate, can also include:
First substrate is placed in vacuum oven and is pre-processed.
It, can after the first control piece in hollow structure is trapped among the periphery of spinning fibre and is fixed in the first substrate
The first substrate to be placed in vacuum oven, heating pretreatment is carried out by vacuum oven, with reinforce spinning fibre with
Binding force between first substrate, to prevent from occurring to spin when removing upper layer high polymer micro-flow control chips from upper mold
The case where silk fiber is stripped down with upper layer high polymer micro-flow control chips, and then improve final prepared high polymer micro-flow control
The quality of chip.
A kind of preparation method of high polymer micro-flow control chips provided in an embodiment of the present invention, utilizes liquid high polymer, upper layer
High polymer micro-flow control chips are prepared in mold and lower mold, may include:
Liquid high polymer is cast in upper mold and in lower mold respectively, and is solidified, is had with correspondence
There are the upper layer high polymer micro-flow control chips and lower layer's high polymer micro-flow control chips of preset thickness, wherein upper layer high polymer micro-flow control
There is microchannel corresponding with spinning fibre on chip；
The mode being by mechanically pulling off strips down upper layer high polymer micro-flow control chips from upper mold, and passes through machine
The mode of tool removing strips down lower layer's high polymer micro-flow control chips from lower mold；
At the endpoint location of microchannel punch, and will on the high polymer micro-flow control chips of upper layer with microchannel one side with
Lower layer's high polymer micro-flow control chips fit together, to obtain high polymer micro-flow control chips.
It can using the detailed process that high polymer micro-flow control chips are prepared in liquid high polymer, upper mold and lower mold
With are as follows:
Step 1: liquid high polymer is poured into upper mold, is stood until liquid high polymer uniformly flow to entire first
Then control piece continues to pour into liquid high polymer and reaches preset thickness, to form upper layer that is having preset thickness and being in a liquid state
High polymer micro-flow control chips；Wherein, preset thickness sets for the thickness previously according to high polymer micro-flow control chips to be prepared
Fixed thickness.
Step 2: similarly, liquid high polymer being poured into lower mold, stand until liquid high polymer uniformly flow to it is whole
Then a second control piece continues to pour into liquid high polymer and reaches preset thickness, have preset thickness to be formed and be in a liquid state
Lower layer's high polymer micro-flow control chips；
Step 3: the upper mold of liquid high polymer will be cast with, lower mold is respectively put into vacuum oven and carries out
Elevated cure, so that liquid Polymer Transitions are solid-state, so that corresponding obtain with preset thickness and in solid upper layer Gao Ju
Object micro-fluidic chip has preset thickness and is in solid lower layer's high polymer micro-flow control chips；Wherein, it is poured into upper mold
Liquid high polymer and after being solidified, due to spinning fibre raised in upper mold, upper layer high polymer micro-flow control
Chip, which can be corresponding with recess in the one side being in contact with upper mold, to be occurred, which is prepared microchannel, i.e., on
There can be microchannel corresponding with spinning fibre on layer high polymer micro-flow control chips；
Step 4: after solidification, the mode that can be by mechanically pulling off will be in solid upper layer high polymer micro-flow control core
Piece is stripped down from upper mold, and the mode that can be by mechanically pulling off will be in solid lower layer's high polymer micro-flow control chips
It is stripped down from lower mold, to obtain independent upper layer high polymer micro-flow control chips and lower layer's high polymer micro-flow control chips；
Step 5: punching at the endpoint location of upper layer high polymer micro-flow control chips microchannel, specifically may refer to Fig. 3,
To obtain sample holes and sample outlet hole；
Step 6: will there is the one side and lower layer's high polymer micro-flow control chips of microchannel on the high polymer micro-flow control chips of upper layer
It fits together, to obtain high polymer micro-flow control chips.It specifically, can be by lower layer's high polymer micro-flow control chips in fitting
Be in contact with the second substrate on the high polymer micro-flow control chips of upper layer with microchannel while fit together.Because under
The one side that layer high polymer micro-flow control chips are in contact with the second substrate is relatively smooth, it is thus possible to improve fitting effect, mentions
The q&r of high final prepared high polymer micro-flow control chips.
The preparation method of a kind of high polymer micro-flow control chips provided in an embodiment of the present invention, by upper layer high polymer micro-flow control
Before one side on chip with microchannel fits together with lower layer high polymer micro-flow control chips, can also include:
Upper layer high polymer micro-flow control chips and lower layer's high polymer micro-flow control chips are cleaned by ultrasonic.
It is bonded by the one side on the high polymer micro-flow control chips of upper layer with microchannel with lower layer high polymer micro-flow control chips
Before together, upper layer high polymer micro-flow control chips and lower layer's high polymer micro-flow control chips can also be cleaned by ultrasonic, with
Wash away upper layer high polymer micro-flow control chips and the pollutants such as dust, particle that lower layer's high polymer micro-flow control chips surface is infected with,
To improve the cleannes of upper layer high polymer micro-flow control chips and lower layer's high polymer micro-flow control chips, the bonding effect of the two is improved,
To improve the cleannes and reliability of final prepared high polymer micro-flow control chips.
The preparation method of a kind of high polymer micro-flow control chips provided in an embodiment of the present invention, by upper layer high polymer micro-flow control
After one side on chip with microchannel fits together with lower layer high polymer micro-flow control chips, can also include:
To upper layer high polymer micro-flow control chips and the lower layer's high polymer micro-flow control chips progress hot-pressing processing of fitting together.
It is bonded by the one side on the high polymer micro-flow control chips of upper layer with microchannel with lower layer high polymer micro-flow control chips
It, can also be to upper layer high polymer micro-flow control chips and the lower layer's high polymer micro-flow control chips progress heat of fitting together after together
Pressure processing, to improve the adhesiveness of the two, to improve the q&r of high polymer micro-flow control chips.
It wherein, specifically can be by the upper layer high polymer micro-flow control chips to fit together and lower layer's high polymer micro-flow control chips
It is put into vacuum oven to carry out hot-pressing processing, to reduce the preparation cost of high polymer micro-flow control chips.
A kind of preparation method of high polymer micro-flow control chips provided in an embodiment of the present invention configures liquid high polymer, can be with
Include:
PDMS performed polymer is prepared using PDMS monomer and curing agent, and PDMS performed polymer is vacuumized.
Configure the detailed process of liquid high polymer are as follows: utilize PDMS monomer (polydimethylsiloxane, poly dimethyl
Siloxanes) and curing agent be prepared into PDMS performed polymer；Then, PDMS performed polymer is vacuumized, to remove in PDMS performed polymer
Gas, to prevent bubble occur when upper mold and lower mold will be poured into PDMS performed polymer.
When being vacuumized to PDMS performed polymer, it can specifically put it into and be vacuumized in vacuum oven, and
Before vacuum extraction, PDMS performed polymer can also be stirred, so that PDMS monomer and curing agent are uniformly mixed, and by stirring
Mix a part of bubble of removal.
Dimethyl silicone polymer has good biocompatibility, excellent optical property, and also has easy to process
With the performance of encapsulation, therefore, being applied to can be improved final prepared height in high polymer micro-flow control chips preparation and gathers
The performance of object micro-fluidic chip, and the preparation cost of high polymer micro-flow control chips can be reduced.
A kind of preparation method of high polymer micro-flow control chips provided in an embodiment of the present invention, utilizes near field electrostatic spinning direct write
Technique orientated deposition spinning fibre in the first substrate may include:
The high polymer of preset value is higher by as near field electrostatic spinning direct-write process using the solidification temperature of fusing point ratio PDMS
Spinning material, and utilize spinning material orientated deposition spinning fibre in the first substrate.
, in orientated deposition spinning fibre in the first substrate, it can use fusing point using near field electrostatic spinning direct-write process
Solidification temperature than PDMS is higher by spinning material of the high polymer of preset value as near field electrostatic spinning direct-write process, is somebody's turn to do with utilizing
Spinning material obtains spinning fibre, this allows for can be used higher solidification temperature and shorter during solidifying PDMS
Curing time, and the fusing point of spinning material is higher, then higher temperature, shorter time can be used to consolidate PDMS
Change, therefore, then can shorten the production cycle of high polymer micro-flow control chips, improve the preparation efficiency of high polymer micro-flow control chips.
It should be noted that, in this document, relational terms such as first and second and the like are used merely to a reality
Body or operation are distinguished with another entity or operation, are deposited without necessarily requiring or implying between these entities or operation
In any actual relationship or order or sequence.Moreover, the terms "include", "comprise" or its any other variant are intended to
Non-exclusive inclusion, so that the element that the process, method, article or equipment including a series of elements is intrinsic.?
Do not have in the case where more limiting, the element limited by sentence "including a ...", it is not excluded that including the element
There is also other identical elements in process, method, article or equipment.In addition, above-mentioned technology provided in an embodiment of the present invention
In scheme with correspond to the consistent part of technical solution realization principle and unspecified in the prior art, in order to avoid excessively repeat.
The foregoing description of the disclosed embodiments can be realized those skilled in the art or using the present invention.To this
A variety of modifications of a little embodiments will be apparent for a person skilled in the art, and the general principles defined herein can
Without departing from the spirit or scope of the present invention, to realize in other embodiments.Therefore, the present invention will not be limited
It is formed on the embodiments shown herein, and is to fit to consistent with the principles and novel features disclosed in this article widest
Range.
Claims (10)
1. a kind of preparation method of high polymer micro-flow control chips characterized by comprising
Using near field electrostatic spinning direct-write process in the first substrate orientated deposition spinning fibre, and by hollow structure first
Control piece is trapped among the periphery of the spinning fibre and is fixed in first substrate, to obtain upper mold；
Shape and size the second control piece identical with first control piece are fixed in the second substrate, to obtain lower layer
Mold；
Liquid high polymer is configured, and height is prepared using the liquid high polymer, the upper mold and the lower mold
Polymers micro-fluidic chip.
2. the preparation method of high polymer micro-flow control chips according to claim 1, which is characterized in that utilizing near-field electrostatic
Spinning direct-write process is in orientated deposition spinning fibre in the first substrate, further includes:
The stacking number of the spinning fibre is controlled.
3. the preparation method of high polymer micro-flow control chips according to claim 2, which is characterized in that spun using near-field electrostatic
Silk direct-write process orientated deposition spinning fibre in the first substrate, comprising:
Using near field electrostatic spinning direct-write process in first substrate orientated deposition nanofiber.
4. according to the preparation method for the high polymer micro-flow control chips that claim 2 is stated, which is characterized in that the spinning fibre
Stacking number is controlled, comprising:
It controls to obtain the stacked structure of cross section semicircular in shape or half elliptic by stacking number.
5. the preparation method of high polymer micro-flow control chips according to claim 1, which is characterized in that will be in hollow structure
The first control piece be trapped among the periphery of the spinning fibre and be fixed in first substrate after, further includes:
First substrate is placed in vacuum oven and is pre-processed.
6. the preparation method of high polymer micro-flow control chips according to claim 1, which is characterized in that high using the liquid
High polymer micro-flow control chips are prepared in polymers, the upper mold and the lower mold, comprising:
The liquid high polymer is cast in respectively in upper mold and in the lower mold, and is solidified, to deserved
To upper layer high polymer micro-flow control chips and lower layer's high polymer micro-flow control chips with preset thickness, wherein the upper layer Gao Ju
There is microchannel corresponding with the spinning fibre on object micro-fluidic chip；
The mode being by mechanically pulling off strips down the upper layer high polymer micro-flow control chips from the upper mold, and leads to
The mode for crossing mechanical stripping strips down lower layer's high polymer micro-flow control chips from the lower mold；
It is punched at the endpoint location of the microchannel, and will there is the microchannel on the upper layer high polymer micro-flow control chips
One side fit together with lower layer's high polymer micro-flow control chips, to obtain the high polymer micro-flow control chips.
7. the preparation method of high polymer micro-flow control chips according to claim 6, which is characterized in that the upper layer is high
Before one side on polymers micro-fluidic chip with the microchannel fits together with lower layer's high polymer micro-flow control chips,
Further include:
The upper layer high polymer micro-flow control chips and lower layer's high polymer micro-flow control chips are cleaned by ultrasonic.
8. the preparation method of high polymer micro-flow control chips according to claim 7, which is characterized in that the upper layer is high
After one side on polymers micro-fluidic chip with the microchannel fits together with lower layer's high polymer micro-flow control chips,
Further include:
At fit together the upper layer high polymer micro-flow control chips and lower layer's high polymer micro-flow control chips progress hot pressing
Reason.
9. the preparation method of high polymer micro-flow control chips according to any one of claims 1 to 8, which is characterized in that configuration
Liquid high polymer, comprising:
PDMS performed polymer is prepared using PDMS monomer and curing agent, and the PDMS performed polymer is vacuumized.
10. the preparation method of high polymer micro-flow control chips according to claim 9, which is characterized in that utilize near-field electrostatic
Spinning direct-write process orientated deposition spinning fibre in the first substrate, comprising:
The high polymer of preset value is higher by as the spinning of near field electrostatic spinning direct-write process using the solidification temperature of fusing point ratio PDMS
Material, and utilize spinning material spinning fibre described in orientated deposition in first substrate.
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Application publication date: 20190823 |