CN110123910A - A kind of Chinese medicine composition and preparation method thereof for treating chronic constipation - Google Patents

A kind of Chinese medicine composition and preparation method thereof for treating chronic constipation Download PDF

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Publication number
CN110123910A
CN110123910A CN201810132174.1A CN201810132174A CN110123910A CN 110123910 A CN110123910 A CN 110123910A CN 201810132174 A CN201810132174 A CN 201810132174A CN 110123910 A CN110123910 A CN 110123910A
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medicine composition
chinese medicine
chronic constipation
defecation
fruit
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CN201810132174.1A
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Inventor
周阿高
毛旭明
陆瑞峰
何方
李朝衡
唐人彦
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Ninth Peoples Hospital Shanghai Jiaotong University School of Medicine
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Ninth Peoples Hospital Shanghai Jiaotong University School of Medicine
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284Atractylodes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/31Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/42Cucurbitaceae (Cucumber family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/537Salvia (sage)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/57Magnoliaceae (Magnolia family)
    • A61K36/575Magnolia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/60Moraceae (Mulberry family), e.g. breadfruit or fig
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/63Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A61K36/638Ligustrum, e.g. Chinese privet
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/75Rutaceae (Rue family)
    • A61K36/752Citrus, e.g. lime, orange or lemon
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/80Scrophulariaceae (Figwort family)
    • A61K36/808Scrophularia (figwort)

Abstract

The present invention provides a kind of Chinese medicine composition and preparation method thereof for treating chronic constipation, and each component and its mass parts ratio of the Chinese medicine composition are as follows: Radix Salviae Miltiorrhizae 5-20g, radish seed 5-20g, radix scrophulariae 5-20g, fruit of glossy privet 5-20g, fructus cannabis 5-20g, Rhizoma Atractylodis Macrocephalae 5-20g, dried immature fruit of citron orange 5-20g, Cortex Magnoliae Officinalis 5-20g, Siraitia grosvenorii 5-20g.It is an advantage of the current invention that the clinical efficacy of traditional Chinese medicine composition for treating chronic constipation disclosed by the invention is significant, it can be effectively improved patients with chronic constipation symptom, it is easy to use.Treatment group's total effective rate is 93.6%, control group 60.0%, P < 0.05.Treatment group feels five aspects in stool interval, defecation time, difficult defecation degree, fecal character, defecation not to the utmost and is significantly improved, and compared with the control group, difference is statistically significant (P < 0.001).

Description

A kind of Chinese medicine composition and preparation method thereof for treating chronic constipation
Technical field
The present invention relates to the field of Chinese medicines more particularly to a kind of Chinese medicine compositions for treating chronic constipation.
Background technique
Chronic constipation is common clinical, frequently-occurring disease, shows as that defecation frequency is reduced, excrement is stiff and (or) defecation is tired Difficulty brings many puzzlements to patient, and serious person influences the quality of life and routine work of patient, may also lead to some complication, Cerebrovascular accident such as can be induced to hypertension, patients with coronary artery disease.The therapeutic effect of chronic constipation is not good enough at present.Drug application and Enema is the conventional means for treating chronic constipation, but cathartic can weaken itself reflection of intestinal wall, eventually aggravate constipation.And Abuse purgatives will cause the adverse reactions such as drug dependence, electrolyte disturbance, and prolonged application may also cause melanosis coli.Separately Outside, hydrotherapy is also a kind of method, and physiological saline is injected anus, through repeated flushing, makes to accumulate the excrement discharge in big enteral, but The therapy is inconvenient.Western medical treatment also often application promotees digestive tract power reinforcing medicine, probiotics, psychology and biofeedback therapy, outer Section's operation etc., but act on limited.
Therefore, it needs to explore a kind of simple, safe and effective Chinese medicine for treating chronic constipation, releases the pain of patient, make The vast constipation patient of good fortune.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine compositions for treating chronic constipation.
Second object of the present invention is, provides a kind of preparation method of Chinese medicine composition for treating chronic constipation.
To realize that above first purpose, the present invention disclose following technical scheme: a kind of Chinese medicine group for treating chronic constipation Close object, which is characterized in that each component and its mass parts ratio of the Chinese medicine composition are as follows: Radix Salviae Miltiorrhizae 5-20g, radish seed 5- 20g, radix scrophulariae 5-20g, fruit of glossy privet 5-20g, fructus cannabis 5-20g, Rhizoma Atractylodis Macrocephalae 5-20g, dried immature fruit of citron orange 5-20g, Cortex Magnoliae Officinalis 5-20g, Siraitia grosvenorii 5- 20g。
As a preferred embodiment, each component and its mass parts ratio of the Chinese medicine composition are as follows: Radix Salviae Miltiorrhizae 3-6, Lay Fu 3-6, radix scrophulariae 3-6, fruit of glossy privet 3-6, fructus cannabis 3-6, Rhizoma Atractylodis Macrocephalae 3-6, dried immature fruit of citron orange 2-4, Cortex Magnoliae Officinalis 2-4, Siraitia grosvenorii 2-4.
As a preferred embodiment, each component and its mass parts ratio of the Chinese medicine composition are as follows: Radix Salviae Miltiorrhizae 3-5, Lay Fu 3-5, radix scrophulariae 3-5, fruit of glossy privet 3-5, fructus cannabis 3-5, Rhizoma Atractylodis Macrocephalae 3-5, dried immature fruit of citron orange 2-3, Cortex Magnoliae Officinalis 2-3, Siraitia grosvenorii 2-3.
To realize that above second purpose, the present invention disclose following technical scheme: a kind of Chinese medicine group for treating chronic constipation Close the preparation method of object, which is characterized in that granule is made than following each component in mass parts: Radix Salviae Miltiorrhizae 5-20g, radish seed 5-20g, radix scrophulariae 5-20g, fruit of glossy privet 5-20g, fructus cannabis 5-20g, Rhizoma Atractylodis Macrocephalae 5-20g, dried immature fruit of citron orange 5-20g, Cortex Magnoliae Officinalis 5-20g, Siraitia grosvenorii 5-20g;
It is preferred that Radix Salviae Miltiorrhizae 3-6, radish seed 3-6, radix scrophulariae 3-6, fruit of glossy privet 3-6, fructus cannabis 3-6, Rhizoma Atractylodis Macrocephalae 3-6, dried immature fruit of citron orange 2-4 are thick Plain 2-4, Siraitia grosvenorii 2-4.
It is further preferred that Radix Salviae Miltiorrhizae 3-5, radish seed 3-5, radix scrophulariae 3-5, fruit of glossy privet 3-5, fructus cannabis 3-5, Rhizoma Atractylodis Macrocephalae 3-5, dried immature fruit of citron orange 2-3, Cortex Magnoliae Officinalis 2-3, Siraitia grosvenorii 2-3.
It is an advantage of the current invention that the clinical efficacy of traditional Chinese medicine composition for treating chronic constipation disclosed by the invention is significant, it can It is effectively improved patients with chronic constipation symptom, it is easy to use.Treatment group's total effective rate is 93.6%, control group 60.0%, P < 0.05.Five aspects are felt in stool interval, defecation time, difficult defecation degree, fecal character, defecation not to the utmost by treatment group to be had significantly Improve, compared with the control group, difference is statistically significant (P < 0.001).
Specific embodiment
Hereinafter, technology of the invention is described in detail in conjunction with specific embodiment.It is appreciated that the various in detail below Embodiment is only used for helping skilled in the art to understand the present invention, rather than limitation of the present invention.
Embodiment 1. leads to secret recipe to the Study of evidence based medicine of 47 patients with chronic constipation
We have carried out evidence-based medicine EBM to 47 patients with chronic constipation with Chinese medicine composition (logical secret recipe) of the invention Research, it was demonstrated that logical secret recipe can be obviously improved tients with constipation's symptom, mitigate patient suffering.
1, clinical data
1.1 general information
Research object selects -2017 years 2013 patients with chronic constipation totally 67, is divided into treatment group and two groups of control group.Its Middle treatment group 47, control group 20.Male 9 in treatment group, women 38;It max age 85 years old, minimal ages 21 years old, puts down The equal age is 58.1 ± 18.9 years old.Male 9 in control group, women 11;It is max age 88 years old, minimal ages 19 years old, average Age is 56.9 ± 20.4 years old.Before two groups of patients treatment in defecation frequency, defecation is time-consuming, discharge degree of difficulty, fecal character, defecation The symptom integral of five aspects such as sense not to the utmost, is statistically analyzed, equal P > 0.05 is comparable.
1.2 diagnostic criteria
Referring to the diagnostic criteria of III functional consitipation of Rome[1]: (1) it must satisfy following 2 or multinomial: a. at least 25% Defecation feel laborious;B. at least 25% defecation is dry bulb excrement or hard excrement;C. at least 25% defecation has feels not to the utmost;D. at least 25% defecation has anorectal obstruction sense and (or) blocking sense;E. at least 25% defecation needs gimmick to help;F. defecation is weekly Less than 3 times;(2) do not have to loose stools seldom occur when cathartic;(3) diagnostic criteria of irritable bowel syndrome is not met.
2. treatment method
2.1 drug
Treatment group: logical secret recipe (granule), prescription: Radix Salviae Miltiorrhizae, radish seed, radix scrophulariae, the fruit of glossy privet, fructus cannabis, Rhizoma Atractylodis Macrocephalae, the dried immature fruit of citron orange, Cortex Magnoliae Officinalis, Siraitia grosvenorii, auxiliary material are starch, every time 1 packet, 2 times a day, are taken orally.Control group: hemp seed soft capsule, by fructus cannabis, bitter apricot Benevolence, rheum officinale, fry the dried immature fruit of citron orange, ginger Cortex Magnoliae Officinalis, stir-baked RADIX PAEONIAE ALBA composition, auxiliary material be palm oil, hydrogenated palm oil, beeswax, phosphatide, salad oil, It is produced by Tianjin Central Pharmaceutical Co., Ltd;2 tablets each time, 2 times a day, it takes orally.
2.2 courses for the treatment of: 3 weeks.
3. observation of curative effect
3.1 observation index:
(1) stool interval: being denoted as 1 point 1~2 day 1 time, is denoted as 3 points 3 days or more 1 time.
(2) defecation time: the stool time is denoted as 1 point within 10 points every time, is denoted as 3 points within 10 minutes or more.
(3) difficult defecation degree: defecation is effortless or is easily firmly denoted as 1 point, defecation moderate force, whole body power or gimmick side Mnemonic(al) is 3 points.
(4) fecal character: soft stool or smooth sausage shape are denoted as 1 point, dry and cracked sausage shape, segmentation scleroma shape or dispersion pyreniform It is denoted as 3 points.
(5) defecation is felt not to the utmost: without or rarely not to the utmost sense be denoted as 1 point, have sometimes, often have or always exist not to the utmost sense be denoted as 3 Point.
3.2 curative effect determinate standards: referring to " Shanghai City Chinese medical disease conventional treatment (second edition) ".
Cure: defecation 1 time within 2 days, just matter turns soft, solves Shi Tongchang.Integral reduces >=2/3 earlier above.
Improve: defecation 1 time within 3 days, just matter is softer, and defecation owes smooth.Integral reduces >=1/3 earlier above.
Invalid: symptom is without improvement.Integral reduces≤1/3 earlier above.
4. statistical method
For statistical analysis using statistic software SPSS 13.0, measurement data is examined using t, and enumeration data uses χ2Inspection It tests, P < 0.05 is that difference has significant meaning.
5. result
The comparison of 5.1 two groups of clinical efficacies
Treatment group's total effective rate is 93.6%, control group 60.0%, P < 0.05.It is shown in Table 1.
1 two groups of tcm clinical practice curative effects of table compare
Note: compared with the control group, P < 0.05 △.
The comparison of the pretherapy and post-treatment symptom integral of each observation index of 5.2 treatment groups
Five aspect treatments are felt in stool interval, defecation time, difficult defecation degree, fecal character, defecation not to the utmost by treatment group Front and back symptom integral has highly significant improvement, and difference is statistically significant (P < 0.001).It is shown in Table 2.
The pretherapy and post-treatment symptom integral of each observation index of 2 treatment group of table compares
Note: compared with before treatment, P < 0.001 △.
The comparison of the pretherapy and post-treatment symptom integral of each observation index of 5.3 control groups
Control group feels four pretherapy and post-treatment symptom integrals of aspect in stool interval, defecation time, fecal character, defecation not to the utmost It is significantly improved, difference is statistically significant (P < 0.05 or P < 0.01);Though having improvement in terms of difficult defecation degree, without aobvious Meaning (P > 0.05).It is shown in Table 3.
The pretherapy and post-treatment symptom integral of each observation index of 3 control group of table compares
Note: compared with before treatment, P < 0.01 △ P < 0.05, △ △.
The comparison of each observation index symptom integral situation after 5.4 two groups of treatments
Through examining, treatment group is in four stool interval, defecation time, difficult defecation degree, fecal character aspect diseases after treatment Shape integral is significantly improved compared with the control group, and difference is statistically significant (P < 0.05 or P < 0.01);Feel not to the utmost in defecation Aspect is had a better effect due to two groups, therefore two groups do not have apparent difference (P > 0.05).It is shown in Table 4.
The comparison of each observation index symptom integral situation after 4 two groups of treatments of table
The hemp seed soft capsule that control group of the present invention uses comes from ancient prescription Maziren Wan (treatise on Febrile Diseases), has preferable defaecation to make With, be treat chronic constipation representative side.But contain rheum officinale composition in the medicine prescription, rheum officinale is cathartic, and long term usage rheum officinale has pair Effect weakens itself reflection of intestinal wall, aggravates constipation, and it is also possible to cause melanosis coli.
Aurantii Immaturi and Atractylodis Pill in component of the present invention is ancient prescription, comes from ancient medical book " differentiation on endogenous " book.The prescription of dried immature fruit of citron orange ball There are Rhizoma Atractylodis Macrocephalae, two taste medicine of the dried immature fruit of citron orange, effect is reinforcing spleen to promote digestion, cures mainly feeling of oppression and fullness in the chest and epigastrium, do not feel like eating, there is certain side to inhibited defecation It helps, but is not mainly treating constipation.
The clinical efficacy of logical secret recipe treatment chronic constipation of the invention is significant.Treatment group (logical secret recipe) total effective rate is 93.6%, control group (hemp seed soft capsule) is 60.0%, P < 0.05.Treatment group is in stool interval, defecation time, difficult defecation Degree, fecal character, defecation feel five aspects not to the utmost and are significantly improved, and compared with the control group, curative effect is substantially better than control group, poor Different statistically significant (P < 0.001).Logical secret recipe can be effectively improved patients with chronic constipation symptom, have safe and effective, user Just the advantages of.
The above is only a preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art Member, various improvements and modifications may be made without departing from the principle of the present invention, these improvements and modifications also should be regarded as Protection scope of the present invention.

Claims (4)

1. a kind of Chinese medicine composition for treating chronic constipation, which is characterized in that each component and its matter of the Chinese medicine composition Measure part ratio it is as follows: Radix Salviae Miltiorrhizae 5-20g, radish seed 5-20g, radix scrophulariae 5-20g, fruit of glossy privet 5-20g, fructus cannabis 5-20g, Rhizoma Atractylodis Macrocephalae 5-20g, Dried immature fruit of citron orange 5-20g, Cortex Magnoliae Officinalis 5-20g, Siraitia grosvenorii 5-20g.
2. a kind of Chinese medicine composition for treating chronic constipation according to claim 1, which is characterized in that the Chinese traditional medicine composition The each component and its mass parts ratio of object are as follows: Radix Salviae Miltiorrhizae 3-6, radish seed 3-6, radix scrophulariae 3-6, fruit of glossy privet 3-6, fructus cannabis 3-6, white Art 3-6, dried immature fruit of citron orange 2-4, Cortex Magnoliae Officinalis 2-4, Siraitia grosvenorii 2-4.
3. a kind of Chinese medicine composition for treating chronic constipation according to claim 1, which is characterized in that the Chinese traditional medicine composition The each component and its mass parts ratio of object are as follows: Radix Salviae Miltiorrhizae 3-5, radish seed 3-5, radix scrophulariae 3-5, fruit of glossy privet 3-5, fructus cannabis 3-5, white Art 3-5, dried immature fruit of citron orange 2-3, Cortex Magnoliae Officinalis 2-3, Siraitia grosvenorii 2-3.
4. the preparation method of the Chinese medicine composition of any treatment chronic constipation of claim 1-3, which is characterized in that by matter Granule is made in any each component of amount part such as claim 1-3.
CN201810132174.1A 2018-02-09 2018-02-09 A kind of Chinese medicine composition and preparation method thereof for treating chronic constipation Pending CN110123910A (en)

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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101129552A (en) * 2007-08-27 2008-02-27 尹克华 Traditional Chinese medicine for treating chronic functional constipation

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101129552A (en) * 2007-08-27 2008-02-27 尹克华 Traditional Chinese medicine for treating chronic functional constipation

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
王大鹏: "《中医行气法及其临床应用》", 31 January 1989, 南开大学出版社 *
金照: "丹参枳术饮治疗慢性功能性便秘", 《浙江中西医结合杂志》 *

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