CN110123660A - Peptides oral health toothpaste containing victory and preparation method thereof - Google Patents
Peptides oral health toothpaste containing victory and preparation method thereof Download PDFInfo
- Publication number
- CN110123660A CN110123660A CN201910546288.5A CN201910546288A CN110123660A CN 110123660 A CN110123660 A CN 110123660A CN 201910546288 A CN201910546288 A CN 201910546288A CN 110123660 A CN110123660 A CN 110123660A
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- CN
- China
- Prior art keywords
- victory
- peptides
- oral cavity
- health care
- combinations
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/522—Antioxidants; Radical scavengers
Abstract
One kind peptides oral health toothpaste containing victory and preparation method thereof, includes palmitoyl tripeptide 3 and four victory peptides, specifically includes palmitoyl tripeptide 3, four victory peptides, rubbing agent, moisturizer, surfactant, thickener and water.The present invention has the function of anti-oxidant, anti-inflammatory, promotion Collagen Proliferation using the i.e. blue copper victory peptide of palmitoyl tripeptide 3, wound healing and four victory peptides is assisted to have detumescence antioedematous for hexanoyl tetrapeptide -3, improve microcirculation, reinforce blood circulation, the effect of promoting ulcer healing can be used for being able to maintain oral cavity fresh and cool health while anti-treating dental ulcer, abscess of throat, periodontitis, gingivitis.
Description
Technical field
The present invention relates to a kind of technology in oral hygiene field, it is specifically a kind of containing victory peptides oral health toothpaste and
Preparation method.
Background technique
Toothpaste is necessary dental care products in people's daily life, and basic function is to clean tooth, pure and fresh mouth
Gas.As the improvement of people's living standards, people's lives habit and consumption idea also increasingly diversification, for the function of toothpaste
It can also focus more on, various toothpaste with health care function occur on the market.
Summary of the invention
The present invention In view of the above shortcomings of the prior art, proposes one kind peptides oral health toothpaste containing victory and its preparation
Method, using palmitoyl tripeptide 3 be blue copper victory peptide have the function of it is anti-oxidant, anti-inflammatory, promote Collagen Proliferation, assistance wound healing and
Four victory peptides are that hexanoyl tetrapeptide -3 has detumescence antioedematous, the effect of improving microcirculation, reinforce blood circulation, promote ulcer healing,
It can be used for being able to maintain oral cavity fresh and cool health while anti-treating dental ulcer, abscess of throat, periodontitis, gingivitis.
The present invention is achieved by the following technical solutions:
The present invention relates to a kind of oral cavity health care toothpaste of peptides containing victory, include palmitoyl tripeptide 3 and four victory peptides, specifically include three victory
Peptide, four victory peptides, rubbing agent, moisturizer, surfactant, thickener and water.
The palmitoyl tripeptide 3, i.e., blue copper win peptide Glycyl-L-Histidyl-L-Lysine, and chemical structural formula is
The four victory peptides are hexanoyl tetrapeptide -3, chemical structural formula are as follows:
The oral cavity health care toothpaste preferably further includes preservative.
The oral cavity health care toothpaste preferably further includes peppermint oil.
The oral cavity health care toothpaste preferably further includes sweetener.
The oral cavity health care toothpaste further preferably its content and mass percent are as follows: palmitoyl tripeptide 3 0.001%~
0.002%, four victory peptides 0.001%~0.002%, rubbing agent 30%~45%, moisturizer 20%~40%, surfactant
1%~3%, thickener 1%~3%, preservative 0.1%~1%, peppermint oil 1%~2%, sweetener 0.1%~0.5% is remaining
Amount is pure water.
The rubbing agent is used but is not limited to: calcium carbonate, calcium monohydrogen phosphate, calcium pyrophosphate, silica, aluminium hydroxide or
A combination thereof.
The moisturizer is used but is not limited to: glycerol, sorbierite, xylitol, polyethylene glycol or combinations thereof.
The surfactant is used but is not limited to: sodium lauryl sulfate, 2- acyloxy key sodium sulfonate or combinations thereof.
The thickener is used but is not limited to: carboxymethyl cellulose, deer horn pectin, hydroxyethyl cellulose, xanthan gum, melon
Your glue, carrageenan or combinations thereof.
The preservative is used but is not limited to: sorbic acid sylvite, sodium benzoate or combinations thereof.
The sweetener is used but is not limited to: xylitol, cyclohexylamine sulfonic acid sodium, saccharin sodium or combinations thereof.
The present invention relates to it is above-mentioned containing victory peptides oral health toothpaste preparation method, by by moisturizer, surfactant,
Thickener and water are thoroughly mixed micelle is made after mixed with the aqueous solution containing palmitoyl tripeptide 3 and four victory peptides and rubbing agent
It is obtained after even through grinding degassing.
Described is sufficiently stirred, using but be not limited to size making pot, be added water under high velocity agitation, stir uniformly saturating to glue
Until bright no powder, stand to allow micelle sufficiently to expand peptization.
The rate 600-1400r/min of the stirring, preferred stirring rate are 900r/min.
The whipping temp is 30-50 DEG C, and preferred whipping temp is 40 DEG C.
Described is uniformly mixed, and peppermint oil and sweetener is preferably further added.
The grinding refers to: being pumped into colloid mill by gear and is ground, is stood after grinding.
The grinding rate is 10-50kg/min, and preferred grinding rate is 15kg/min.
Technical effect
Compared with prior art, the palmitoyl tripeptide 3 and four victory peptides that the present invention uses belong to short peptide series polypeptide, easily by human body
It absorbs, safety substance without side-effects has the characteristics that dosage is few but can play maximum effect, has by palmitoyl tripeptide 3 anti-
Oxidation, the function of promoting Collagen Proliferation, assist wound healing, four victory peptides detumescence antioedematous, diminish inflammation, improve microcirculation, can
For anti-treating dental ulcer, abscess of throat, periodontitis, gingivitis, moreover it is possible to keep oral cavity fresh and cool hygienic.
Specific embodiment
Embodiment 1
The present embodiment is related to a kind of peptides oral health toothpaste containing victory, each component percentage are as follows: commercially available indigo plant copper wins peptide 1g, city
Sell hexanoyl tetrapeptide -3 1g, calcium carbonate 40kg, polyethylene glycol 25kg, sodium lauryl sulfate 2kg, guar gum 2kg, sorbic acid sylvite
0.5kg, peppermint oil 1kg, saccharin sodium 0.2kg, surplus are water 29.3kg.
The blue copper wins peptide Glycyl-L-Histidyl-L-Lysine, and chemical structural formula is
The palmitoyl tripeptide 3 is purchased from Sichuan Ji Sheng biological medicine Co., Ltd.
The four victory peptides are hexanoyl tetrapeptide -3, chemical structural formula are as follows:
The hexanoyl tetrapeptide -3 is from Chengdu Yun Xi Chemical Co., Ltd..
The present embodiment is related to the peptides oral health toothpaste preparation method containing victory under said ratio, specifically includes following step
It is rapid:
Polyethylene glycol, sodium lauryl sulfate and guar gum are put into size making pot, water is added under high velocity agitation, stirring is extremely
Glue homogeneous transparent until no powder, then places a period of time, after allowing micelle sufficiently to expand peptization, glue is squeezed into kneading
Machine, is added calcium carbonate, peppermint oil, and the aqueous solution of saccharin sodium and blue copper victory peptide and hexanoyl tetrapeptide -3 is mediated uniform.
Colloid mill is pumped by gear to be ground, under mechanical shearing force so that the agglomerated masses of colloid or powder into
One step homogenous disperse is uniformly distributed so that the various particles in lotion reach.A period of time is placed after grinding.
Degassed treated lotion is bright fine and smooth, and stripping is good, filling and packaging.
Embodiment 2
The present embodiment is related to a kind of peptides oral health toothpaste containing victory, each component percentage are as follows: and commercially available indigo plant copper wins peptide 1.5g,
Commercially available -3 1.5g of hexanoyl tetrapeptide, calcium monohydrogen phosphate 45kg, glycerol 28kg, 2- acyloxy key sodium sulfonate 2.5kg, hydroxyethyl cellulose
2.2kg, sodium benzoate 0.5kg, peppermint oil 1kg, saccharin sodium 0.3kg, surplus are water 20.5kg.
The present embodiment is related to the peptides oral health toothpaste preparation method containing victory under said ratio, specifically includes following step
It is rapid:
Glycerol, 2- acyloxy key sodium sulfonate and hydroxyethyl cellulose are put into size making pot, water is added under high velocity agitation,
Stirring is to glue homogeneous transparent, until no powder, then places a period of time, after allowing micelle sufficiently to expand peptization, glue is beaten
Enter kneader, calcium monohydrogen phosphate, peppermint oil is added, the aqueous solution of saccharin sodium and palmitoyl tripeptide 3 and hexanoyl tetrapeptide -3 is mediated uniform.
Colloid mill is pumped by gear to be ground, under mechanical shearing force so that the agglomerated masses of colloid or powder into
One step homogenous disperse is uniformly distributed so that the various particles in lotion reach.A period of time is placed after grinding.
Degassed treated lotion is bright fine and smooth, and stripping is good, filling and packaging.
Embodiment 3
The present embodiment is related to a kind of peptides oral health toothpaste containing victory, each component percentage are as follows: commercially available indigo plant copper wins peptide 2g, city
Sell hexanoyl tetrapeptide -3 2g, calcium pyrophosphate 35kg, xylitol 23kg, sodium lauryl sulfate 2kg, xanthan gum 2kg, sorbic acid sylvite
0.5kg, peppermint oil 1kg, saccharin sodium 0.3kg, surplus are water 36.2kg.
The present embodiment is related to the peptides oral health toothpaste preparation method containing victory under said ratio, specifically includes following step
It is rapid:
Xylitol, sodium lauryl sulfate and xanthan gum are put into size making pot, water, stirring to glue are added under high velocity agitation
Water homogeneous transparent until no powder, then places a period of time, after allowing micelle sufficiently to expand peptization, glue is squeezed into kneader,
Calcium pyrophosphate, peppermint oil is added, the aqueous solution of saccharin sodium and palmitoyl tripeptide 3 and hexanoyl tetrapeptide -3 is mediated uniform.
Colloid mill is pumped by gear to be ground, under mechanical shearing force so that the agglomerated masses of colloid or powder into
One step homogenous disperse is uniformly distributed so that the various particles in lotion reach.A period of time is placed after grinding.
Degassed treated lotion is bright fine and smooth, and stripping is good, filling and packaging.
Above-mentioned specific implementation can by those skilled in the art under the premise of without departing substantially from the principle of the invention and objective with difference
Mode carry out local directed complete set to it, protection scope of the present invention is subject to claims and not by above-mentioned specific implementation institute
Limit, each implementation within its scope is by the constraint of the present invention.
Claims (10)
1. a kind of oral cavity health care toothpaste of the peptides containing victory, includes palmitoyl tripeptide 3 and four victory peptides, specifically includes palmitoyl tripeptide 3, four victory peptides, rubs
Liniment, moisturizer, surfactant, thickener and water；
The palmitoyl tripeptide 3, i.e., blue copper win peptide Glycyl-L-Histidyl-L-Lysine, and chemical structural formula is
The four victory peptides are hexanoyl tetrapeptide -3, chemical structural formula are as follows:
2. oral cavity health care toothpaste according to claim 1, characterized in that further include preservative, peppermint oil, sweetener
Or combinations thereof.
3. oral cavity health care toothpaste according to claim 1, characterized in that its content and mass percent are as follows: palmitoyl tripeptide 3
0.001%~0.002%, four victory peptides 0.001%~0.002%, rubbing agent 30%~45%, moisturizer 20%~40%, table
Face activating agent 1%~3%, thickener 1%~3%, preservative 0.1%~1%, peppermint oil 1%~2%, sweetener 0.1%~
0.5%, surplus is pure water.
4. oral cavity health care toothpaste according to claim 1 or 3, characterized in that the rubbing agent uses: calcium carbonate, phosphorus
Sour hydrogen calcium, calcium pyrophosphate, silica, aluminium hydroxide or combinations thereof.
5. oral cavity health care toothpaste according to claim 1 or 3, characterized in that the moisturizer uses: glycerol, sorb
Alcohol, xylitol, polyethylene glycol or combinations thereof.
6. oral cavity health care toothpaste according to claim 1 or 3, characterized in that the surfactant uses: lauryl alcohol
Sodium sulphate, 2- acyloxy key sodium sulfonate or combinations thereof.
7. oral cavity health care toothpaste according to claim 1 or 3, characterized in that the thickener uses: carboxymethyl cellulose
Element, deer horn pectin, hydroxyethyl cellulose, xanthan gum, guar gum, carrageenan or combinations thereof.
8. oral cavity health care toothpaste according to claim 3, characterized in that the preservative uses: sorbic acid sylvite, benzene
Sodium formate or combinations thereof；The sweetener uses: xylitol, cyclohexylamine sulfonic acid sodium, saccharin sodium or combinations thereof.
9. a kind of method for preparing the peptides oral health toothpaste containing victory described in any of the above-described claim, which is characterized in that pass through
Moisturizer, surfactant, thickener and water are thoroughly mixed after micelle is made and the water containing palmitoyl tripeptide 3 and four victory peptides
Ground degassing obtains after mixing for solution and rubbing agent.
10. according to the method described in claim 9, it is characterized in that, described is sufficiently stirred, using size making pot, in high-speed stirred
Lower addition water stirs until glue homogeneous transparent is without powder, stands to allow micelle sufficiently to expand peptization；
The grinding refers to: being pumped into colloid mill by gear and is ground, is stood after grinding.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910546288.5A CN110123660A (en) | 2019-06-21 | 2019-06-21 | Peptides oral health toothpaste containing victory and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910546288.5A CN110123660A (en) | 2019-06-21 | 2019-06-21 | Peptides oral health toothpaste containing victory and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110123660A true CN110123660A (en) | 2019-08-16 |
Family
ID=67579149
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910546288.5A Pending CN110123660A (en) | 2019-06-21 | 2019-06-21 | Peptides oral health toothpaste containing victory and preparation method thereof |
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20050020148A (en) * | 2003-08-21 | 2005-03-04 | (주) 그린생활건강 | Nano shell composition comprising copper peptide, xylitol and tocopherol and an oral hygiene composition containing the nano shell composition |
| CN105147534A (en) * | 2015-08-28 | 2015-12-16 | 深圳市维琪医药研发有限公司 | Polypeptide composition for skin repairing |
| CN105407858A (en) * | 2013-03-15 | 2016-03-16 | Cda研究集团股份有限公司 | Topical copper ion treatments |
| CN105769696A (en) * | 2016-04-15 | 2016-07-20 | 山东天欣生物科技有限公司 | Chinese herbal toothpaste containing fish collagen protein peptide |
| CN106619332A (en) * | 2017-03-02 | 2017-05-10 | 山西锦波生物医药股份有限公司 | Palmitoyl pentapeptide-containing biological curing toothpaste and production method thereof |
| CN107028829A (en) * | 2017-04-25 | 2017-08-11 | 攀枝花学院 | Compound mango leaf extract anti-inflammatory health toothpaste and preparation method thereof |
-
2019
- 2019-06-21 CN CN201910546288.5A patent/CN110123660A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20050020148A (en) * | 2003-08-21 | 2005-03-04 | (주) 그린생활건강 | Nano shell composition comprising copper peptide, xylitol and tocopherol and an oral hygiene composition containing the nano shell composition |
| CN105407858A (en) * | 2013-03-15 | 2016-03-16 | Cda研究集团股份有限公司 | Topical copper ion treatments |
| CN105147534A (en) * | 2015-08-28 | 2015-12-16 | 深圳市维琪医药研发有限公司 | Polypeptide composition for skin repairing |
| CN105769696A (en) * | 2016-04-15 | 2016-07-20 | 山东天欣生物科技有限公司 | Chinese herbal toothpaste containing fish collagen protein peptide |
| CN106619332A (en) * | 2017-03-02 | 2017-05-10 | 山西锦波生物医药股份有限公司 | Palmitoyl pentapeptide-containing biological curing toothpaste and production method thereof |
| CN107028829A (en) * | 2017-04-25 | 2017-08-11 | 攀枝花学院 | Compound mango leaf extract anti-inflammatory health toothpaste and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 唐瞻贵: "《口腔黏膜下纤维化 基础与临床》", 31 July 2017, 科学技术文献出版社 * |
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Application publication date: 20190816 |