CN110118811A - The distribution structure and pattern detection orifice plate of pattern detection orifice plate - Google Patents
The distribution structure and pattern detection orifice plate of pattern detection orifice plate Download PDFInfo
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- CN110118811A CN110118811A CN201810121860.9A CN201810121860A CN110118811A CN 110118811 A CN110118811 A CN 110118811A CN 201810121860 A CN201810121860 A CN 201810121860A CN 110118811 A CN110118811 A CN 110118811A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
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Abstract
The present invention provides the distribution structure and pattern detection orifice plate of a kind of pattern detection orifice plate, pattern detection orifice plate has underlay substrate, the surface side of underlay substrate is provided with multiple detecting electrodes, each of multiple detecting electrodes includes the opposite electrode that the working electrode for being applied voltage and one were detected and exported detection signal, distribution structure includes the power supply wiring for powering to above-mentioned working electrode and the signal wiring for exporting the detection signal of opposite electrode, each of above-mentioned power supply wiring and signal wiring respectively include being configured in the surface wiring part on the surface of above-mentioned underlay substrate, it is configured in the back side wiring part on the back side of above-mentioned underlay substrate, and the perforation wiring part for penetrating through above-mentioned underlay substrate and connecting above-mentioned surface wiring part with above-mentioned back side wiring part.The present invention can be reduced the wiring lengths of the surface side of underlay substrate, reduce wiring density, improve the wiring design freedom of underlay substrate surface side and back side.
Description
Summary of the invention
The present invention relates to a kind of distribution structure of pattern detection orifice plate and pattern detection orifice plates.
Background technique
In detection of biological samples field, especially in the detection field of liquid biopsy, usually using sample testing apparatus
To detect biological sample.The sample testing apparatus includes: shell, is divided into bottom case and cover board；Structure is kept, has and is arranged upper
The pressurizer stating the retainer in the above-mentioned bottom case of shell and being arranged on the cover board of above-mentioned shell；Pattern detection orifice plate,
For holding biological sample, there are cassette shapes, be placed in the holding part of above-mentioned retainer, and pressurizeed by above-mentioned pressurizer
And it is kept by above-mentioned holding structure；And probe module passes through the detection of probe and the pattern detection orifice plate with probe
Electrode conduction is to power to the pattern detection orifice plate and export detection signal from the pattern detection orifice plate.
Above-mentioned pattern detection orifice plate has multiple holes, and a biological sample can be held in each hole, is passed through
One-time detection is carried out to a pattern detection orifice plate and improves detection so as to disposably complete the detection of multiple samples
Efficiency.Bottom (surface side of pattern detection orifice plate) in each hole is respectively arranged with detecting electrode, utilizes detection electricity
Extremely the biological sample being placed in hole is detected, thus the low current signal of biological sample can be defeated by detecting electrode
Out to the signal detection processing unit outside orifice plate.
Fig. 1 is the illustrative perspective view of an example of the pattern detection orifice plate of the prior art, and Fig. 2 is the pattern detection
Illustrative top view when the slave surface side observation of orifice plate.As depicted in figs. 1 and 2, pattern detection orifice plate includes a box body
100, the box body 100 top with multiple holes 109 and lower part have underlay substrate 101, the shape on the underlay substrate 101
At there is detector electrode structure.Box body 100 has 8 rows × 12 column hole 109, is 96 orifice plates, each column hole is divided into 2 inspections
Survey group, each detection group have 4 adjacent holes 109.
Fig. 3 is the illustrative perspective view of hole and detecting electrode.As shown in figure 3, detector electrode structure is in underlay substrate
Accordingly include one with each hole 109 on 101 to be used to detect for applying alive working electrode 103 and one
Signal and the opposite electrode 104 for exporting the detection signal, the first main part 1030 of working electrode 103 and opposite electrode 104
Second main part 1040 is located at except detection zone 102, a part in multiple first threadiness portion 1031 of working electrode 103 and right
The a part for setting the second threadiness portion 1041 of electrode 104 is located in detection zone 102.
Fig. 4 is the illustrative wiring diagram of the pattern detection orifice plate of the prior art.As shown in figure 4, shape on underlay substrate 101
At having conducting wire 111 and conducting wire 112, four working electrodes 103 are electrical connected by conducting wire 111, and conducting wire 112 is opposed with four respectively
Electrode 104 is electrical connected to draw the electric signal of opposite electrode 104.
Fig. 5 is the illustrative side view of the pattern detection orifice plate of the prior art.As shown in figure 5, in underlay substrate 101
Back side is provided with a circuit board 110 along the edge of underlay substrate 101 respectively in two sides.Above-mentioned conducting wire 111 and conducting wire
112 extend to the edge of the underlay substrate 101 on the surface of underlay substrate 101, and further along the side of underlay substrate 101
Extend downwardly, around underlay substrate 101 back side and with the circuit connection in circuit board 110, thus, it is possible to pass through circuit board
110 power to each working electrode 103 and receive detection signal from each opposite electrode 104.About box body 100 and detector electrode structure
More detailed structure, be referred to CN205844251U disclosure of that, be not described in further detail herein.
Fig. 6 is facing upward for the circuit board for the back side setting for being shown schematically in the pattern detection orifice plate of the above-mentioned prior art
View.As shown in fig. 6, being provided with multiple conductive contacts 113 on above-mentioned circuit board 110 with being typically arranged to a row, utilize
Probe 133 in probe module is passed through externally to 110 input voltage of circuit board and further via multiple conductive contact 113
Input voltage is applied to working electrode 103 by conductive path, the conducting wire 111 in circuit board 110, also, by opposite electrode
Detection signal is via the conductive path and multiple conductive contact 113 in conducting wire 112, circuit board 110 detected by 104
It is transmitted to probe 133.
Fig. 7 is to schematically show the retainer of the above-mentioned prior art and the top view of probe module and cross-sectional view.Such as
Shown in Fig. 7, the fence 132 that retainer 130 has bottom plate 131 and holds up upwards from bottom plate 131 is marked off by fence 132
For keeping the holding space 135 of template detection orifice plate.In the inside in the holding space 135 of retainer 130, it is provided with probe mould
Block, the probe module are formed with the electricity of the back side of 2 row's probes 133, the quantity of the probe 133 and position and template detection orifice plate
Conductive contact 113 on road plate 110 is consistent.It is kept in space 135 by the way that pattern detection orifice plate to be embedded into, and is applied from top
Plus-pressure realizes the conducting between circuit board 110 and probe module to make probe 133 and 113 Elastic Contact of conductive contact,
Make it possible to apply voltage to working electrode 103 via probe 133, and can export and detect from opposite electrode 104 via probe
Signal.
In above-mentioned pattern detection orifice plate, conductive contact 113 is arranged on the circuit of the back side of pattern detection orifice plate
It on plate 110, is arranged at pattern detection orifice plate both sides of the edge, surface gold-plating, and accessible area is larger, in the case, visits
Needle top is dome and surface is smooth, can be contacted well with contact.
Summary of the invention
Present invention technical problem to be solved
In the pattern detection orifice plate of above-mentioned structure, conducting wire 111 and conducting wire 112 respectively from each working electrode 103 and
Opposite electrode 104 extends to the back side of underlay substrate 101 and connect with circuit board 111, in the case, in underlay substrate
101 surface side needs to be arranged a plurality of conducting wire 111,112 from edge side to inside for each detection group, conducting wire 111,
112 quantity is more, and area occupied is big, and the wiring density of conducting wire 111,112 is big, and conductor spacing is small, wiring layout design difficulties,
Wiring width and the design freedom of spacing are small, and wiring craft precision requires high, layout complexity.If reducing conducting wire 111,112
The problem of line width, cost improves not there is only technology difficulty raising, there is also conductor resistances to become larger, is easy the problems such as broken string.
In addition, it is necessary to which circuit board 110 is arranged at 101 back side both sides of the edge of underlay substrate, cause number of components more, and wiring needs
It is electrically connected across underlay substrate 101 and 110 ground of circuit board, complex process.
The present invention in view of the above-mentioned problems, proposes a kind of distribution structure of pattern detection orifice plate and has the wiring
The pattern detection orifice plate of structure realizes above-mentioned purpose, can reduce the wiring lengths of the surface side of underlay substrate, reduces wiring
Density improves the wiring design freedom of underlay substrate surface side and back side, reduces equipment and technique requirement, also, be not required to
Circuit board is fixedly attached to the back side of underlay substrate, reduces the number of parts and volume of pattern detection orifice plate.
The technical solution adopted by the present invention to solve the technical problems
A technical solution of the invention is a kind of distribution structure of pattern detection orifice plate, and above-mentioned pattern detection orifice plate has
Underlay substrate is provided with multiple detecting electrodes, each packet of above-mentioned multiple detecting electrodes in the surface side of above-mentioned underlay substrate
Include working electrode that one is applied voltage and an opposite electrode for being detected and being exported detection signal, above-mentioned distribution structure
Including the power supply wiring for powering to above-mentioned working electrode and the signal for exporting the detection signal of above-mentioned opposite electrode
Each of wiring, above-mentioned power supply wiring and signal wiring respectively include being configured in the surface on the surface of above-mentioned underlay substrate
Wiring part, the back side wiring part being configured on the back side of above-mentioned underlay substrate and the above-mentioned underlay substrate of perforation simultaneously will
The perforation wiring part that above-mentioned surface wiring part is connect with above-mentioned back side wiring part.
In the distribution structure of above-mentioned pattern detection orifice plate, above-mentioned surface wiring part is configured in above-mentioned detecting electrode
Detection zone outside.
In the distribution structure of above-mentioned pattern detection orifice plate, above-mentioned multiple detecting electrodes are divided into multiple detection groups,
Working electrode in each detection group is connected to the identical back side via surface wiring part and perforation wiring part respectively
Wiring part.
In the distribution structure of above-mentioned pattern detection orifice plate, there are four above-mentioned work electricity in each above-mentioned detection group
Pole, wherein the above-mentioned working electrode of every two is connected to same surface wiring part, wherein each surface wiring part is in
Three trouble shapes, the Liang Ge branch in above-mentioned three troubles shape connect with two above-mentioned working electrodes respectively, and third branch passes through perforation
Wiring is attached partially to back side wiring part.
In the distribution structure of above-mentioned pattern detection orifice plate, the work of each detecting electrode in above-mentioned multiple detecting electrodes
Different surface wiring parts is connected respectively to as electrode.
In the distribution structure of above-mentioned pattern detection orifice plate, pair of each detecting electrode in above-mentioned multiple detecting electrodes
It sets electrode and is connected respectively to different surface wiring parts.
In the distribution structure of above-mentioned pattern detection orifice plate, it is equipped on above-mentioned back side wiring part for being connect with probe
The contact of touching.
In the distribution structure of above-mentioned pattern detection orifice plate, multiple working electrodes in above-mentioned multiple detecting electrodes via
Surface wiring part and perforation wiring part and be connected to identical back side wiring part.
In the distribution structure of above-mentioned pattern detection orifice plate, above-mentioned back side wiring part and above-mentioned contact are by conductive silver
Slurry is printed by using silk screen print method.
Another technical solution of the invention is a kind of pattern detection orifice plate, and above-mentioned pattern detection orifice plate includes box body, on
Stating box body includes multiple holes and the underlay substrate for accommodating detection sample, and is provided on the underlay substrate above-mentioned
Distribution structure.
Beneficial effects of the present invention
Distribution structure according to the present invention and pattern detection orifice plate with the distribution structure, can reduce substrate base
The conductor length of the surface side of plate reduces wiring density, also, does not need the back that circuit board is fixedly attached to underlay substrate
The number of parts and volume of pattern detection orifice plate are reduced in surface side.
In the absence of conflict, the feature in the same embodiment of the invention and different embodiment can be combined with each other.
Detailed description of the invention
By following attached drawing, those skilled in the art will present invention may be better understood, and advantages of the present invention
It will more clearly be embodied.Attached drawing described herein is only for illustrating the purpose of embodiment, rather than all feasible embodiment party
Formula, and be not intended to limit the scope of the invention.
Fig. 1 is the illustrative perspective view of an example of the pattern detection orifice plate of the prior art.
Illustrative top view when Fig. 2 is the slave surface side observation of the pattern detection orifice plate of the prior art.
Fig. 3 is the hole of the pattern detection orifice plate of the prior art and the illustrative perspective view of detecting electrode.
Fig. 4 is the illustrative wiring diagram of the pattern detection orifice plate of the prior art.
Fig. 5 is the illustrative side view of the pattern detection orifice plate of the prior art.
Fig. 6 is facing upward for the circuit board for the back side setting for being shown schematically in the pattern detection orifice plate of the above-mentioned prior art
View.
Fig. 7 is to schematically show the retainer of the above-mentioned prior art and the top view of probe module and cross-sectional view.
Fig. 8 is the illustrative perspective view of one embodiment of the pattern detection orifice plate of embodiments of the present invention.
Illustrative top view when Fig. 9 is the slave surface side observation of the pattern detection orifice plate of embodiments of the present invention.
Figure 10 is the detecting electrode and wiring in a detection group for indicate the pattern detection orifice plate of the embodiment of the present invention
Slave back side observation bottom view.
Figure 11 is the detecting electrode and wiring in a detection group for indicate the pattern detection orifice plate of the embodiment of the present invention
The side view from side.
Figure 12 is the detecting electrode and wiring in a detection group for indicate the pattern detection orifice plate of variation of the invention
Slave back side observation bottom view.
Figure 13 is the top view for schematically showing retainer and probe module.
Figure 14 A is the sectional view along its longitudinal direction of probe, and Figure 14 B is signal when probe is arranged in electrical insulating board
Figure.
Figure 15 is the top perspective view for indicating the top of the spring contact of probe of embodiment.
Figure 16 A is the top perspective view for indicating the top of probe of variation, and Figure 16 B is the top for indicating the probe of variation
The left side view at end.
Figure 17 is the perspective view for indicating sample testing apparatus of the invention.
Specific embodiment
Preferred embodiment in accordance with the present invention is described in detail below with reference to attached drawing.By attached drawing and accordingly
Explanatory note, skilled person will further understand that the features of the present invention and advantage.
[pattern detection orifice plate]
Fig. 8 is the illustrative perspective view of the embodiment of the pattern detection orifice plate of embodiments of the present invention.Fig. 9 is this hair
Illustrative top view when the slave surface side observation of the pattern detection orifice plate of bright embodiment.
As shown in Figure 8 and Figure 9, pattern detection orifice plate 200 includes a box body 208.Box body 208 generallys use transparent
Material is made, in order to observe and measure, with 8 rows × 12 holes 209 arranged, it is 96 orifice plates, each column hole is divided into 2
Detection group, each detection group include 4 adjacent holes 209.Box body 208 has underlay substrate 201 in bottom, in the substrate base
On plate 201, it is formed with the detection structure including detecting electrode and wiring.It should be noted that the row in hole possessed by box body
Columns, each group of hole number for including are not limited to the quantity of above-mentioned record, can suitably set according to actual needs, each group
It inside may include more or fewer hole numbers, can not also be grouped and be detected by 1 hole for unit.
[distribution structure]
Figure 10 is the detecting electrode and wiring in a detection group for indicate the pattern detection orifice plate of the embodiment of the present invention
Slave back side observation top view.In Figure 10, detection structure is only illustrated, omits the diagram of other components such as hole 209, separately
Outside, detecting electrode corresponding with 4 holes 209 and the wiring in 1 detection group, the inspection of other detection groups and diagram are illustrated only
Survey group uses identical configuration.Further, since underlay substrate is made of transparent material, it is possible to penetrate underlay substrate from the back side
See the detecting electrode and wiring of surface side in side.Figure 11 is a detection for indicating the pattern detection orifice plate of the embodiment of the present invention
The side view from side of detecting electrode and wiring in group.Since underlay substrate is made of transparent material, it is possible to
Internal perforation wiring is seen through underlay substrate.
As shown in Figures 10 and 11, the detection structure in 1 detection group includes underlay substrate 201 (in Figure 10 and Figure 11
Divided with double dot dash line), 4 detecting electrodes 202 and distribution structure.
Detecting electrode 202 includes: working electrode 203 (2031,2032,2033,2034), working electrode 203 and above-mentioned
Hole 209 is arranged in correspondence on underlay substrate 201, for applying voltage to form electric field；And opposite electrode 204 (2041,
2042,2043,2044), opposite electrode 204 and above-mentioned hole 209 are arranged in correspondence on underlay substrate 201, for obtaining
Detection signal simultaneously exports the detection signal.Referring to Fig. 3 of the prior art, the main body of working electrode 203 and opposite electrode 204
It is partly arranged at outside detection zone, detection part configures in detection zone.Working electrode 203 and opposite electrode 204 are respectively provided with
In the surface side of underlay substrate 201, therefore, working electrode 203 and opposite electrode 204 can be in the same plane.Due to lining
Substrate 201 uses transparent material same as box body 208, so when from back side, it can be seen that configuration is serving as a contrast
The working electrode 203 and opposite electrode 204 of the surface side of substrate 201.
It, can be using existing knot shown in Fig. 3, Fig. 4 about the detailed construction of working electrode 203 and opposite electrode 204
Structure, but it is not limited to Fig. 3, structure shown in Fig. 4, it is referred to CN205844251U disclosure of that and selects any one
Electrode structure, such as spiral shape, in this detailed description will be omitted.
In the embodiment shown in Figure 10 and Figure 11, in 1 detection group, by 2 adjacent detecting electrodes 202 with 2
Working electrode 2031,2032 is closer to each other and the mode of 2 opposite electrodes 2041,2042 away from each other configures, by other 2
Adjacent detecting electrode 202 is closer to each other with 2 working electrodes 2033,2034 and 2 opposite electrodes 2043,2044 are remote each other
From mode configure, that is, configure to 2 202 mirror symmetries of detecting electrode.
In Fig. 8 and embodiment shown in Fig. 9, pattern detection orifice plate 200 proceeds as follows detection.By to work
Electrode 203 applies voltage and generates electric field to keep the target substance being infused in hole 209 mobile and assemble, for example, to work
Electrode 203 can apply square wave alternating voltage, first make the substance of the electrification in liquid to be detected including target substance to work electricity
The mobile enrichment in pole 203 so that target substance can with probe on working electrode 203 is (not shown) combines, the then pole of shift voltage
Property, so that substance of other in the substance of electrification not in conjunction with probe is far from (work of the electric field to target substance of working electrode 203
Firmly it is set smaller than the binding force of target substance and probe).Opposite electrode 204 obtains the detection signal about target substance
And will test signal output, for example, the target substance in conjunction with probe can react with specific reagent and generate electric current, because
This opposite electrode 204 can obtain the detection signal about target substance by detection electric current and will test signal output.Pass through
The detection signal of analysis output can obtain the information (such as concentration of target substance) about target substance, so as to rapid, quasi-
Really detected.
Therefore, it is necessary to each 203 service voltage of working electrode, and by electric current detected by each opposite electrode 204
Signal output, that is, need each working electrode 203 and each opposite electrode 204 and external electrical connections through distribution structure.
Hereinafter, the distribution structure for the embodiment that the present invention will be described in detail.
As shown in Figures 10 and 11, distribution structure includes power supply wiring 211 and signal wiring 212, the power supply wiring 211
And signal wiring 212 all configures outside the detection zone of detecting electrode.
Power supply wiring 211 has surface power supply wiring 211a (surface wiring part, figure in show with hollow wire body), the back side
Power supply wiring 211b (back side wiring part, figure in shown with filled black wire body), power contact 211c and perforation wiring
211d.Surface power supply wiring 211a is configured in the surface side of underlay substrate 201 and extends along the surface of underlay substrate 201,
Back side power supply wiring 211b is configured in the back side of underlay substrate 201 and extends along the back side of underlay substrate 201.Surface
Power supply wiring 211a is formed three trouble shapes (being shown in FIG. 10 "T"-shaped), the first branch and the second branch of the three troubles shape
It is connect respectively with 2 working electrodes 203, the third branch of the three troubles shape connect with perforation wiring 211d, back side power supply wiring
One end of 211b is connect with perforation wiring 211d, and the other end is connect with power contact 211c.The perforation wiring 211d is with by substrate
Substrate is configured along the perforative mode of its thickness direction, and one end is connect with surface power supply wiring 211a, the other end and back side power supply
Wiring 211b connection, so that surface power supply wiring 211a and back side power supply wiring 211b is electrically connected.Power contact 211c can be with
It is integrally formed that (power contact also can be considered one of back side power supply wiring in the same process with back side power supply wiring 211b
Point), it can also be respectively formed in different processes.
In embodiment, have in 4 working electrodes 203 in 1 detection group and share 1 surface power supply wiring 211a's
2 adjacent 203,1 surface power supply wiring 211a of working electrode have 3 branches and wherein 2 branches are respectively electric with 1 work
Pole 203 connects, total to have 2 surface power supply wiring 211a.Also, 2 surface power supply wiring 211a are respectively via perforation wiring
211d is connect with back side power supply wiring 211b, and 1 power contact 211c is provided on the power supply wiring 211b of the back side.As a result, from outer
Portion's power supply is matched via 1 power contact 211c, back side power supply wiring 211b, 2 perforation wiring 211d and 2 surface power supplys
Line 211a to power to 4 working electrodes 203.
Signal wiring 212 has surface signal wiring 212a (surface wiring part, figure in show with hollow body), back side letter
Number wiring 212b (back side wiring part, figure in shown with filled black body), signalling contact 212c and perforation wiring 212d.
Surface signal wiring 212a is configured in the surface side of underlay substrate 201 and extends along the surface of underlay substrate 201, the back side
Signal wiring 212b is configured in the back side of underlay substrate 201 and extends along the back side of underlay substrate 201.Surface signal is matched
One end of line 212a is connect with opposite electrode 204, and the other end is connect with perforation wiring 212d, one end of back side signal wiring 212b
It is connect with perforation wiring 212d, and overleaf (in this case, it is back side letters equipped with signalling contact 212c by signal wiring 212b
The other end of number wiring 212b).The perforation wiring 212d by by underlay substrate along its thickness direction it is perforative in a manner of configure, one
End is connect with surface signal wiring 212a, and the other end is connect with back side signal wiring 212b, by surface signal wiring 212a and back
Face signal wiring 212b electrical connection.Signalling contact 212c is integrally formed in the same process with back side signal wiring 212b
(a part that signalling contact also can be considered back side signal wiring) can also be respectively formed in different processes.
In embodiment, each of 4 opposite electrodes 204 in 1 detection group is connected with 1 surface signal and matches
Line 212a, it is total to have 4 surface signal wiring 212a.Also, 4 surface signal wiring 212a are respectively via perforation wiring 212d
It is connect with 4 back side signal wiring 212b, is respectively equipped with 1 signalling contact 212c on every back side signal wiring 212b.As a result,
By detection signal detected by 4 opposite electrodes 204 via 4 surface signal wiring 212a, 4 perforation wiring 212d, 4
Back side signal wiring 212b and 4 signalling contact 212c is output in external analytical equipment.
It should be noted that being only the configuration mode illustrated shown in Figure 10 and Figure 11, the present invention is not limited to Figure 10 and figures
Configuration mode shown in 11, also can change, multiple detecting electrodes in 1 group and wiring can be achieved using various
The configuration mode of detection.
For example, instantiated in Figure 10 2 adjacent working electrodes 203 share 1 perforation wiring 211d, and with it is "T"-shaped
Surface power supply wiring 211a connection, still, surface power supply wiring 211a is not limited to T shape, is also possible to Y-shaped, " V " shape.Separately
Outside, the surface power supply wiring 211a for 1 line segment shape for connecting 2 adjacent working electrodes 203, the both ends of the line segment be can also be
The working electrode 203 adjacent with 2 is connect respectively, and perforation wiring 211d is provided in the middle part of the line segment.
In addition, instantiating in Figure 10 has 4 detecting electrodes 202 in 1 detection group, and 4 detecting electrodes 202 are linear
Arrangement, still, and the arrangement mode of 4 detecting electrodes 202 is without being limited thereto, can also be in star-arrangement (2 × 2 array).Herein
In the case of, the working electrode 203 of 4 detecting electrodes 202 is connected to 1 perforation wiring 211d by surface power supply wiring respectively,
And it is communicated to back side power supply wiring 211b, power contact 211c via this 1 perforation wiring 211d, 4 detecting electrodes as a result,
202 share 1 perforation wiring 211d, 1 back side power supply wiring 211b and 1 power contact 211c.
Hereinafter, illustrating the variation of the configuration mode of detecting electrode and wiring.
Figure 12 is the detecting electrode and wiring in a detection group for indicate the pattern detection orifice plate of variation of the invention
Slave back side observation bottom view.Hereinafter, be based on Figure 12, only illustrate with the difference of the above embodiments, for it is upper
The identical content of the embodiment stated omits the description.
Variation and embodiment the difference lies in that 2 adjacent detecting electrodes in 1 detection group not with mirror symmetry
Mode configure, but all detecting electrodes all repeatedly use identical configuration mode, moreover, with each detecting electrode connect
The wiring connect also all repeatedly uses identical configuration mode.In the variation, each working electrode does not share power supply wiring.
That is, as shown in figure 12, the opposite electrode in 4 detecting electrodes all configures in left side, and each opposite electrode is connected with 1
Signal wirings, the working electrode in 4 detecting electrodes all configure on right side, and each working electrode is connected with 1 power supply wiring.
Alternatively, opposite electrode, signal wiring, working electrode, power supply wiring and above-mentioned configuration mode are configured reversed left to rightly.
More than, detecting electrode and distribution structure are described in detail based on attached drawing and there is the detecting electrode and match knot
The embodiment and variation of the pattern detection orifice plate of structure, still, distribution structure are not limited to the above embodiments and variation, detection
Electrode can take various forms, and the quantity of the detecting electrode in each detection group can be selected arbitrarily according to actual needs, match
The path of wiring in cable architecture, whether using wiring, common contact is shared, can select according to actual needs.
Hereinafter, illustrating the effect of the distribution structure of pattern detection orifice plate.
According to the distribution structure of the pattern detection orifice plate of embodiment and variation, by power supply wiring, one of signal wiring
Divide and be disposed through wiring and back side wiring, it is not necessary to which all configuration is on underlay substrate surface by power supply wiring, signal wiring, also not
It must be all drawn out to the side edge of underlay substrate, shorten the length of power supply wiring on underlay substrate surface, signal wiring as a result,
Degree reduces the density of power supply wiring on underlay substrate surface, signal wiring, so that the detection electricity on underlay substrate surface
The freedom degree being routed in gap between pole increases, and wiring design becomes easier to.Also, due to wiring each other it
Between spacing increase, allow the dimensional accuracy of wiring, position precision that there is bigger error, reduce and be used to form setting for wiring
Standby, tool requirement, can save cost.
According to the distribution structure of the pattern detection orifice plate of embodiment and variation, power supply is formed on the back side of underlay substrate
Contact, signalling contact, it is not necessary to power supply wiring, signal wiring are drawn out to the side edge of underlay substrate, and further existed with setting
The circuit board at the underlay substrate back side connects, and not only simplifies the number of components for reducing pattern detection orifice plate with Wiring technology as a result,
Amount, moreover, the spacing between the contact being arranged on the underlay substrate back side can be than being intensively arranged contact on circuit boards
Between spacing it is bigger, enable to for from contact obtain detection signal probe between spacing increase, probe mould
The design freedom of block is bigger.
According to the distribution structure of the pattern detection orifice plate of embodiment and variation, due to back side power supply wiring, back side signal
Wiring, power contact, signalling contact are formed in the back side of underlay substrate, are not formed in the same process with detecting electrode, no
It needs to the detecting electrode of surface side craft precision exigent like that, therefore, it is possible to use conductive silver paste passes through screen printing
Brush method is formed.
[probe module]
In the case where above-mentioned pattern detection orifice plate 200, there is no circuit board in the back side of underlay substrate, contact is direct
It is formed on the back side of underlay substrate, is made of conductive silver paste, correspondingly, the spy for cooperating with the pattern detection orifice plate
The probe location of pin module also changes compared with prior art, be not configured in probe module with pattern detection orifice plate
The corresponding position in both sides of the edge, and be distributed across in the entire surface of probe module.
Figure 13 is the top view for schematically showing retainer and probe module.It is illustrated only in Figure 13 in a detection group
Probe, the diagram of other probes is omitted.
As shown in figure 13, the fence 532 that retainer 530 has bottom plate 531 and holds up upwards from bottom plate 531, the bottom of by
Plate 531 and fence 532 mark off the holding space 535 for keeping template detection orifice plate.It is keeping being provided with spy in space 535
Pin module 600.Probe module 600 may include multiple probes 610 and electrical insulating board 630, and electrical insulating board 630 is arranged on holding
On the bottom plate 531 of the inside in the holding space 535 of device 530, multiple probes 633 are distributed in the inside for keeping space 535, the probe
633 quantity and position are consistent with template detection the power contact 211c and signalling contact 212c of back side of orifice plate 200.Figure
That illustrate in 13 is power contact 211c in a detection group with the pattern detection orifice plate 200 of above-described embodiment, signal touching
Corresponding 5 probes 633 of point 212c.It should be noted that when using the distribution structure of variation, the quantity meeting of probe 610
It correspondingly changes, for example, the probe 633 when the distribution structure of the variation shown in corresponding diagram 12, in each detection group
Quantity be 8.
Herein, it also can be omitted the electrical insulating board 630 of probe module 600, in the case, multiple probes 610 are threaded through
Electrical insulating board on the bottom plate 531 of retainer 530, by the bottom plate 531 of retainer 530 as probe module 600.
It is kept in space 535, and applied pressure from above by the way that pattern detection orifice plate 200 to be embedded into, to make probe
633 with power contact 411c, signalling contact 412c Elastic Contact, realize 600 between pattern detection orifice plate 200 and probe module
Conducting makes it possible to apply voltage to working electrode 203 via probe 633, and can be via probe 610 from opposite electrode 204
Export detection signal.
[probe]
Figure 14 A is the sectional view along its longitudinal direction of probe, and Figure 14 B is signal when probe is arranged in electrical insulating board
Figure.
Probe module 600 may include multiple probes 610 and electrical insulating board 630.Figure 14 A and 14B are please referred to, is shown
The structure of one probe 610.As shown in figure 13, probe 610 may include probe body 612, such as with tubular form, the spy
Needle main body 612 can be arranged on electrical insulating board 630 (bottom plate 531 for being also possible to retainer 530) (Figure 14 B), for example, passing through
It is interference fitted and wears.Probe body 612 can have opening 614 at one end, and limit stroke space 613, the trip in inside
Space 613 is connected to opening 614.Probe body 612 is being obstructed with the 614 opposite other ends of opening, and is wrapped at the end
Include the terminal for being electrically connected to orifice plate retainer circuit.Probe 610 can further include spring contact 611, and spring contact 611 can hang down
Directly in the movement of bottom plate 531 for keeping space 535.As shown in Figure 14 A, spring contact 611 may include top section 6111, shoulder
6112 and compresses lower section 6113.Shoulder 6112 and compresses lower section 6113 are located in the stroke space 613, the shoulder
6112 can be engaged in the peripheral portion for limiting the opening 614 in stroke space, and top section 6111 is extended from shoulder 6112
Opening 614, compresses lower section 6113 is from shoulder 6112 towards stroke space internal stretch.Compresses lower section 6113 and stroke space bottom
Between settable elastic element 616, for example, helical spring.When top section 6111 is by contact pressure F straight down,
Spring contact 611 can overcome the restoring force of spring 616 and translate downwards, and shoulder 6112 is detached from and the peripheral portion of opening 614
Engagement.When pressure F release, spring contact 611 can reset under the action of the restoring force of spring 616.Probe 610 is whole can
It is made of metal material.
In the present invention, since power contact 211c, signalling contact 212c are formed directly into the back side of underlay substrate 201
On, compared with formation in the prior art on circuit boards conductive contact, possible contact area becomes smaller.Further, since using leading
Electric silver paste is made, the bullet compared with being made of copper on circuit board in the prior art and gold-plated conductive contact, with probe 610
The contact performance possible deviation on the top of property contact 611.Therefore, it is necessary to take measures to ensure that probe 610 and power contact
211c, signalling contact 212c contact are good.
Figure 15 is the top perspective view for indicating the top of the spring contact of probe of embodiment.As shown in Figure 15, probe
610 top surface is circular flat 640, and horizontally extending transverse groove 641 and longitudinal direction are offered on the circular flat 640
Slot 642, transverse groove 641 and longitudinal slot 642 intersect and circular flat 640 are divided into multiple regions.Transverse groove 641 and longitudinal slot
642 have certain depth and form recess portion, so that it is multiple small to be divided into 611 top end part of spring contact of probe 610
Protrusion 643.The minute protrusions 643 of multiple quadrangles are in the grid-shaped arrangement in the top end part of probe 610, with transverse groove 641 and vertical
Multiple small bumps are formed together to slot 642.For the irregular minute protrusions of multiple non-quadrangles of circumferential edges
643, it both can remove, can also retain.
When pattern detection orifice plate 200 being embedded into holding space 535 and being applied pressure from above, the top of probe 610
Multiple minute protrusions 643 of end contact with power contact 211c, signalling contact 212c under stress and are pierced into power supply touching
Inside point 211c, signalling contact 212c, to keep good contact with power contact 211c, signalling contact 212c.
In the above-described embodiment, illustrate that probe 610 offers transverse groove 641 and longitudinal direction on its circular flat 640
Slot 642, still, the direction of slot are not limited to transverse direction and longitudinal direction, as long as intersect and can by the tip portion of probe 610 every
Multiple minute protrusions 643 out, then the direction of slot can be any direction, such as the plan view shape of minute protrusions 643 can be water chestnut
Shape.
In addition, the plan view shape of minute protrusions 643 is not limited to quadrangle, it is also possible to hexagon, other polygons can also
To be round.
Figure 16 A is the top perspective view for indicating the top of probe of variation, and Figure 16 B is the top for indicating the probe of variation
The left side view at end.As shown in Figure 16 A, Figure 16 B, the small convex of multiple tetragonous cone table shapes is formed in the top end part of probe 710
743 are played, the cross-sectional area of minute protrusions 743 becomes smaller from bottom to top, that is, the shape that there is minute protrusions 743 top to come to a point
Shape.
Top based on the minute protrusions 743 comes to a point shape, keeps space 535 pattern detection orifice plate 200 to be embedded into
Interior and when applying pressure from above, multiple minute protrusions 743 of the top end part of probe 710 are easier to be pierced into electricity under stress
Inside source contact 211c, signalling contact 212c, to keep good contact with power contact 211c, signalling contact 212c.
In addition, although it is rectangular pyramid mesa-shaped that Figure 16 A, Figure 16 B, which show minute protrusions 743, it is however not limited to this, pyramid
The side of mesa-shaped is also possible to other quantity, such as trigone is pyramidal, hexagonal pyramid mesa-shaped, eight pyramid mesa-shapeds, furthermore, it is also possible to be round
It is pyramidal.
It is usually adopted about the cross sectional shape of probe 610,710 in order to be matched with power contact 211c, signalling contact 212c
It is round in an embodiment of the present invention and in variation with shape identical with power contact 211c, signalling contact 212c.Such as
Fruit power contact 211c, signalling contact 212c use other shapes, then the cross sectional shape of probe 610,710 can also be correspondingly
Using matched shape.But not limited to this, the cross sectional shape of probe can also be different from the shape of contact, for example, using circle
In the case where shape contact, the cross sectional shape of probe is also possible to polygon, as long as can be realized the contact of the two.
In addition, it is contemplated that in the foozle of contact 211c, 212c of pattern detection orifice plate 200 itself, probe module 600
Probe 610 foozle and pattern detection orifice plate 200 is being embedded into keep space 535 in when position alignment miss
Difference, may cause probe 610,710 from power contact 211c, signalling contact 212c center deviation and cause not to be optimum contact
State, or completely offset from power contact 211c, signalling contact 212c and can not contact.In the present invention, in view of each contact point
Cloth is in the back side of underlay substrate, and accordingly, probe 610 is distributed across the comprehensive of electrical insulating board 630 to the distribution with contact
On, and be located at the region except the detecting electrode 202 on pattern detection orifice plate 200 it is corresponding and with pattern detection orifice plate 200
On the corresponding position contact 211c, 212c on, the spacing between probe is larger, and compared with prior art, contact is indirect
Become larger, the spacing of probe also becomes larger, therefore, can be by probe enlargement.By increasing the radial dimension of probe, so that probe
610,710 top surface is bigger than power contact 211c, signalling contact 212c, thus pattern detection orifice plate 200 is embedded into guarantor
When holding in space 535, even if producing position alignment error, the top surface of probe 610,710 can also cover power contact
211c, signalling contact 212c, it is accordingly possible to ensure probe 610,710 and power contact 211c, signalling contact 212c connect well
Touching.
Hereinafter, illustrating the effect of probe and probe module.
The probe and probe module of embodiment according to the present invention and variation are integrally formed as putting down at the top of probe
Face, also, multiple minute asperities are provided with, as a result, when being embedded into pattern detection orifice plate in holding space, the top of probe
Multiple minute protrusions can be pierced into the contact surface being formed on the back side of the underlay substrate of pattern detection orifice plate, thus
Ensure to contact well between probe and contact.
The probe and probe module of embodiment according to the present invention and variation are formed multiple small at the top of probe
The shape that there is protrusion top to attenuate, as a result, when being embedded into pattern detection orifice plate in holding space, so that the top of probe
Multiple minute protrusions be easier in the contact surface being pierced on the back side for the underlay substrate for being formed on pattern detection orifice plate,
It thereby further ensures that and is contacted well between probe and contact.
The sample probe and probe module of embodiment according to the present invention and variation, the cross sectional shape of probe is than contact
Cross sectional shape is bigger, even if producing alignment error when being embedded into pattern detection orifice plate and keeping in space as a result, also can
Contact is covered with the top surface of probe, so that it is guaranteed that can contact between probe and contact.
[sample testing apparatus]
Figure 17 is the perspective view for indicating sample testing apparatus of the invention.As shown in figure 17, sample testing apparatus 800 includes
Bottom case 801 and cover board 802, are connected by a hinge between bottom case 801 and cover board 802, and cover board 802 can be around figure chain lines X institute
The axis shown is rotated relative to bottom case 801, to close or open.Panel 803 is provided on the upper surface of bottom case 801,
It is provided with opening on panel 803, is provided with above-mentioned retainer 530 in the openings, the retainer 530 is for keeping above-mentioned
Pattern detection orifice plate 200.The upper of corresponding model is put into according to the model of pattern detection orifice plate 200 in the bottom of retainer 530
The probe module 600 stated.Position corresponding with retainer 530 on cover board 802 is provided with pressurizer 536.By pattern detection
Orifice plate 200 is put into the holding space 535 divided by fence 532 and bottom plate 535, and cover board 802 is made to rotate and close around axis X
Cover board is closed, pressurizer 536 presses the upper surface of pattern detection orifice plate 200, applies as a result, to pattern detection orifice plate 200 scheduled
Pressure makes each contact 211c, 212c of pattern detection orifice plate 200 contact and lead with each probe 610 of the probe module 600 of lower section
It is logical.About the other structures of sample testing apparatus, existing structure disclosed in CN106290476A can refer to, omit herein detailed
Thin explanation.
Sample testing apparatus according to the present invention can be obtained using above-mentioned pattern detection orifice plate and probe module
Technical effect possessed by pattern detection orifice plate and probe module.
Although better model of the invention to execution has carried out detailed description, those skilled in the art can be obtained
Know within the scope of the appended claims be used to implement many alternative designs and embodiments of the invention.
Claims (10)
1. a kind of distribution structure of pattern detection orifice plate, above-mentioned pattern detection orifice plate has underlay substrate, in above-mentioned underlay substrate
Surface side be provided with multiple detecting electrodes, each of above-mentioned multiple detecting electrodes includes the work electricity for being applied voltage
Pole and one are detected and are exported the opposite electrode of detection signal, which is characterized in that
Above-mentioned distribution structure includes power supply wiring for powering to above-mentioned working electrode and for by the inspection of above-mentioned opposite electrode
The signal wiring of signal output is surveyed,
Each of above-mentioned power supply wiring and signal wiring respectively include being configured in the surface on the surface of above-mentioned underlay substrate
Wiring part, the back side wiring part being configured on the back side of above-mentioned underlay substrate and the above-mentioned underlay substrate of perforation simultaneously will
The perforation wiring part that above-mentioned surface wiring part is connect with above-mentioned back side wiring part.
2. the distribution structure of pattern detection orifice plate as described in claim 1, which is characterized in that
Above-mentioned surface wiring part is configured in the outside of the detection zone of above-mentioned detecting electrode.
3. the distribution structure of pattern detection orifice plate as claimed in claim 2, which is characterized in that
Above-mentioned multiple detecting electrodes are divided into multiple detection groups,
Working electrode in each detection group is connected to identical via surface wiring part and perforation wiring part respectively
Back side wiring part.
4. the distribution structure of pattern detection orifice plate as claimed in claim 3, which is characterized in that
Above-mentioned working electrode there are four in each above-mentioned detection group,
Wherein, the above-mentioned working electrode of every two is connected to same surface wiring part,
Wherein, each surface wiring part in three trouble shapes, it is above-mentioned three trouble shape in Liang Ge branch respectively with two above-mentioned works
Make electrode connection, and third branch is attached partially to back side wiring part by penetrating through wiring.
5. the distribution structure of pattern detection orifice plate as described in claim 1, which is characterized in that
The working electrode of each detecting electrode in above-mentioned multiple detecting electrodes is connected respectively to different surface wiring parts.
6. the distribution structure of the pattern detection orifice plate as described in any one of claim 1 to 5, which is characterized in that
The opposite electrode of each detecting electrode in above-mentioned multiple detecting electrodes is connected respectively to different surface wiring parts.
7. the distribution structure of the pattern detection orifice plate as described in any one of claim 1 to 5, which is characterized in that
The contact for contacting with probe is equipped on above-mentioned back side wiring part.
8. the distribution structure of the pattern detection orifice plate as described in claim 1,2 or 5, which is characterized in that
Multiple working electrodes in above-mentioned multiple detecting electrodes are connected to via surface wiring part and perforation wiring part
Identical back side wiring part.
9. the distribution structure of pattern detection orifice plate as claimed in claim 7, which is characterized in that
Above-mentioned back side wiring part and above-mentioned contact are printed by conductive silver paste by using silk screen print method.
10. a kind of pattern detection orifice plate, which is characterized in that
Above-mentioned pattern detection orifice plate includes box body,
Above-mentioned box body includes the multiple holes and underlay substrate for accommodating detection sample, and is provided on the underlay substrate
Described in any item distribution structures of claim 1 to 9.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810121860.9A CN110118811A (en) | 2018-02-07 | 2018-02-07 | The distribution structure and pattern detection orifice plate of pattern detection orifice plate |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810121860.9A CN110118811A (en) | 2018-02-07 | 2018-02-07 | The distribution structure and pattern detection orifice plate of pattern detection orifice plate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110118811A true CN110118811A (en) | 2019-08-13 |
Family
ID=67520082
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810121860.9A Pending CN110118811A (en) | 2018-02-07 | 2018-02-07 | The distribution structure and pattern detection orifice plate of pattern detection orifice plate |
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| CN (1) | CN110118811A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113189169A (en) * | 2021-03-31 | 2021-07-30 | 广州钰芯传感科技有限公司 | Multiple microelectrode integrated sensing chip and application thereof in biochemical enzyme-free rapid detection |
| CN113189168A (en) * | 2021-03-31 | 2021-07-30 | 广州钰芯传感科技有限公司 | Microelectrode integrated sensing chip and application thereof in rapid detection of organic pollutants in water |
-
2018
- 2018-02-07 CN CN201810121860.9A patent/CN110118811A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113189169A (en) * | 2021-03-31 | 2021-07-30 | 广州钰芯传感科技有限公司 | Multiple microelectrode integrated sensing chip and application thereof in biochemical enzyme-free rapid detection |
| CN113189168A (en) * | 2021-03-31 | 2021-07-30 | 广州钰芯传感科技有限公司 | Microelectrode integrated sensing chip and application thereof in rapid detection of organic pollutants in water |
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