CN110118750A - Hand-held spectrophotometer based on smart phone - Google Patents
Hand-held spectrophotometer based on smart phone Download PDFInfo
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- CN110118750A CN110118750A CN201910392713.XA CN201910392713A CN110118750A CN 110118750 A CN110118750 A CN 110118750A CN 201910392713 A CN201910392713 A CN 201910392713A CN 110118750 A CN110118750 A CN 110118750A
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- spectrophotometer
- smart phone
- light
- spectrum
- portable
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/39—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using tunable lasers
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/314—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry with comparison of measurements at specific and non-specific wavelengths
- G01N2021/3148—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry with comparison of measurements at specific and non-specific wavelengths using three or more wavelengths
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- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Optics & Photonics (AREA)
- Spectrometry And Color Measurement (AREA)
Abstract
The invention discloses the hand-held spectrophotometers based on smart phone, include planchet, total reflective mirror, collector lens, beam splitting system and imaging system, wherein smart phone is imaged and is analyzed as spectrum of the imaging system to sample.Use solar source to provide the detection range of wide spectrum as spectrophotometer, while effectively saving the volume of spectrophotometer.Hand-held spectrophotometer compact based on smart phone, light channel structure is simple, resolution ratio easy to use and operate while with higher and sensitivity can push spectrophotometer to using under the more universal environmental condition such as outdoor, family and remote mountain areas.
Description
Technical field
The present invention relates to the hand-held spectrophotometers based on smart phone, belong to miniaturization biological detection equipment and technology neck
Domain.
Background technique
Nowadays the use of smart phone is very universal, while smart phone has data processing, data storage and data cloud
Have there are many biological detection platforms combined with smart phone in the advantages such as end transmission.Spectrophotometer is biology, doctor
It treats, one of most important detection platform in the various fields such as agricultural and chemical analysis.Majority spectrophotometer is bulky at present,
Structure is complicated, expensive, not readily portable, can only be confined to use under the academic expertises such as laboratory.Usual many miniaturizations
The broad spectrum light source of spectrophotometer configuration mostly uses halogen lamp, this causes certain limitation to the reduction of optical path volume and needs
Power supply to be provided for detection platform, meanwhile, spectrophotometer needs again after receiving signal using photoelectric sensor by computer
Measurement result is analyzed.
Summary of the invention
The object of the present invention is to provide it is a kind of it is easy to carry, light channel structure is simple, utilize sunlight as spectrophotometer
Light source, smart phone shoots to obtain high-precision measurement result as sensor, and can be with the software of exploitation to spectrum song
The hand-held spectrophotometer based on smart phone that knot fruit is analyzed.
The first purpose of the invention is to provide a kind of portable spectrophotometer, including total reflective mirror, collector lens and point
Photosystem；The total length of optical axis locating for the total reflective mirror, collector lens and beam splitting system is no more than 120mm；The light splitting system
System includes optical filtering pin hole, short focal length lens, spectro-grating.
In one embodiment of the invention, the focal point of collector lens is arranged in the optical filtering pin hole, filters out convergence
Other than light in astigmatism.
In one embodiment of the invention, the collector lens is optically focused biconvex lens, focal length 25.4mm.
In one embodiment of the invention, the spectrophotometer also contains the region for placing planchet, the region
It is arranged before total reflective mirror.
In one embodiment of the invention, the region for placing planchet opens up hole, can make the light of external light source
Line through hole irradiates entering light road.
In one embodiment of the invention, the spectrum intensity range of the applicable light source of the spectrophotometer is visible
In light 350nm-800nm.
In one embodiment of the invention, the surface turns of the spectro-grating and the angle of optical axis are clockwise
26 ° of -28 ° of directions, which can satisfy, only to be allowed in first-order diffraction spectral reflectance to the field range of the rear camera of smart phone.
A second object of the present invention is to provide a kind of method for detecting absorbance, the method is using any of the above-described described
Spectrophotometer, cooperate have camera function smart phone, pass through smart phone acquire spectrophotometer present absorption
Spectrogram, and absorbance data is converted for spectrum picture by operation method.
In one embodiment of the invention, the operation method includes: following steps:
(1) number for selecting calibration point, demarcates the relationship between pixel position and wavelength；
(2) reading that the laser calibration point that shooting obtains carries out respective pixel position is chosen；
(3) calibration maps read end post analysis and obtain the pixel of imaging system and the corresponding linear relationship curve of wavelength；
(4) absorption spectrum curve can be converted by reading any obtained sample absorption spectra line chart that shoots.
In one embodiment of the invention, the operation method specifically:
S1 sets calibration point number.
S2 reads in shooting figure of the Calibration of Laser point after optical system, reads spatial distribution in one-row pixels, intensity
The corresponding location of pixels of peak value, determines location of pixels corresponding to Calibration of Laser wavelength.
S3 demarcates wavelength by three obtained and they is respectively corresponded after running through the calibration maps for setting number
Pixel position, between wavelength and location of pixels corresponding relationship carry out linear fit, so that it is determined that out in areas imaging
Wavelength value corresponding to each pixel.
S4 reads in the sample spectrum diagram that shooting obtains, the intensity-conversion Cheng Qiang of image line pixel after completing calibration
The curve distribution of angle value, then the corresponding relationship by demarcating determine coordinate position, intensity map can be converted to spatial distribution
Curve.
The utility model has the advantages that the component size that the present invention is included is small, light weight, price is low, is greatly saved entire platform
Cost, while light channel structure is compact, and small in size, the size of platform is 140.2 × 67.1 × 80.5mm (length × width × height).This
The spatial distribution that invention shooting obtains is uniform, and resolving accuracy is high, and the response linear coefficient to concentration variation is 0.998, with tradition
The linear response coefficient of the spectrophotometer of business is suitable.And it is furnished with application software in mobile phone, the light that shooting can be obtained
Spectrogram is converted to a quantitative successive line, convenient for further accurate observation and analysis.The present invention can use 3D printing
Technology is packaged and fixes to the connection between light channel structure and beam splitting system and imaging system, in order to carry and make
With.It may be implemented in the more common environment such as field or family and in-site measurement and analysis carried out to sample.
Detailed description of the invention
Fig. 1 is light channel structure figure of the invention；Wherein, 1, planchet；2, total reflective mirror,；3, collector lens；4, optical filtering needle
Hole；5, short focal length lens；6, spectro-grating；7, smart phone.
Fig. 2 is the surface chart of application program of mobile phone of the invention.
Fig. 3 is the spectrogram demarcated to Fig. 1 device progress location of pixels and wavelength relationship.
Fig. 4 is the matched curve of relationship between pixel and wavelength in Fig. 1 appliance imaging system.
Fig. 5 is various concentration (2ug/ml, 4ug/ml, 6ug/ml, 8ug/ml, 10ug/ml) sieve that present invention shooting obtains
The abosrption spectrogram of red bright (R6G) sample solution.
Fig. 6 is various concentration (2ug/ml, 4ug/ml, 6ug/ml, 8ug/ml, 10ug/ml) rhodamine (R6G) sample solution
Absorption spectrum curve.
Fig. 7 is the linear relationship chart between the present invention obtained sample concentration of measurement and absorbance.
Fig. 8 is the linear relationship chart and biography between the bird flu sample and absorbance of the various concentration that present invention measurement obtains
The linear response curve figure of the commercial spectrophotometer of system.
Specific embodiment
In the case where not illustrating, the smart phone referred in the present invention refers to the intelligent hand with camera function
Machine, the sensor photosensitive range of mobile phone are capable of the wide spectrum region of covering visible light 350nm-800nm.
With specific embodiment, the invention will be further described with reference to the accompanying drawing, referring to Fig. 1-8:
Embodiment 1:
As shown in Figure 1, spectrophotometer of the invention includes that total reflective mirror 2, collector lens 3, optical filtering pin hole 4, short focus are saturating
Mirror 5 and spectro-grating 6；Total reflective mirror 2, collector lens 3, optical filtering pin hole 4, short focal length lens 5 and spectro-grating 6 are sequentially arranged
On same optical axis direction；The focal point of collector lens 3 is arranged in the optical filtering pin hole 4, and lenticular can be selected in the collector lens 3
Mirror, biconvex lens focus of the light beam on optical filtering pin hole, filter out other than converged light in astigmatism, improve signal-to-noise ratio；The optical filtering
The light that pin hole 4 is emitted is point light source, and point light source dissipates standby short focal length lens 5 and assembles, and light beam is irradiated in the form of converged light
6 surface of spectro-grating；The short focal length lens 5 is small-bore short focus lens；The spectro-grating 6 is reflective gratings
The angle of (1200 pairs of grooves), the surface turns of spectro-grating 6 and optical axis can satisfy in 26 ° of -28 ° of directions clockwise and only allow one
In the field range for the rear camera that grade difraction spectrum is reflected into smart phone 7.Short focal length lens 5 and optical filtering pin hole 4 and divide
The spacing of light grating 6 is 36.15mm, and the imaging that absorption spectrum can be made to be shot by smart phone reaches the resolution of 0.28nm/pix
Rate.Planchet 1 is placed before the total reflective mirror 2；The biconvex lens of large aperture short focus can be selected in the collector lens 3；The sample
Hole is opened up before product ware 1, the light through hole of external light source can be made to irradiate entering light road.The spectrum of light source is in visible light 350nm-
Optical power detection in 800nm.
Beam splitting system of the invention (including total reflective mirror 2, collector lens 3, optical filtering pin hole 4, short focal length lens 5 and light splitting light
Grid 6) total length on optical axis is not more than the length of mobile phone, and optical axis direction is parallel with mobile phone plane.
The smart phone can convert image information to the numerical information of absorbance, the specific steps are as follows:
S1 sets calibration point number.
S2 reads in shooting figure of the Calibration of Laser point after optical system, reads spatial distribution in one-row pixels, intensity
The corresponding location of pixels of peak value, determines location of pixels corresponding to Calibration of Laser wavelength.
S3 demarcates wavelength by three obtained and they is respectively corresponded after running through the calibration maps for setting number
Pixel position, between wavelength and location of pixels corresponding relationship carry out linear fit, so that it is determined that out in areas imaging
Wavelength value corresponding to each pixel.
S4 reads in the sample spectrum diagram that shooting obtains, the intensity-conversion Cheng Qiang of image line pixel after completing calibration
The curve distribution of angle value, then the corresponding relationship by demarcating determine coordinate position, intensity map can be converted to spatial distribution
Curve.
Realize operation interface such as Fig. 2 of the software of above-mentioned steps, wherein A is the icon of application software, and B is that initial interface mentions
For the option of calibration, measurement, operation instruction and end, C is the interface for selecting calibration point number, after choosing calibration point number
Calibration interface can be entered；D, the interface F, H is all to read laser calibration spectrogram, the Calibration of Laser hot spot that E, G, I are then
The corresponding curve of spectrum of figure, has obtained pixel wavelength plot by the determination to Calibration of Laser facula position and has been shown in boundary
Face J, the save button for clicking interface save the wavelength location of calibration.Calibration enters after saving reads spectral intensity photo
Interface K click calibration, obtain the distribution results of the curve of spectrum as shown in the L of interface.
Application method and working principle of the invention are as follows: spectrophotometer of the invention is horizontally arranged with mobile phone, makes intelligence
Can mobile phone camera be in spectro-grating 6 can be in the range of imaging.Using sunlight as broad spectrum light source, it is irradiated to sample
1 surface of ware, the light that planchet 1 transmits are reflected into 3 surface of collector lens by reflecting mirror 2, and light beam is converged to by collector lens 3
Optical filtering pin hole 4 is traveled at short focal length lens 5 after filtering out stray light in the form of point light source, the light beam of 5 rear surface of imaging len
6 surface of grating is incident in the form of converged light, the spectrum after the light splitting of grating 6 is received by the camera of smart phone 7,
Image information is converted to by the image processing method built in smart phone the numerical information of absorbance.
Embodiment 2:
It is imaged respectively by the laser point of center wavelength of 450nm, 532nm and 650nm, to determine the pixel calibrated
Corresponding relationship between point position and wavelength value.Its light intensity is corresponding on sensor pixel position to be distributed as shown in figure 3, passing through mark
Determine linear relationship (Fig. 4) between the pixel and wavelength of smart phone imaging sensor, linear coefficient in the position for determining luminous point
For R2=0998, linear coefficient indicates that Linear Quasi is right higher closer to 1.Meanwhile smart phone shoots to obtain imaging spectral
Resolution ratio can reach 0.28nm/pixel.
Embodiment 4:
(2ug/ml, 4ug/ml, 6ug/ml, 8ug/ml, the 10ug/ml) rhodamine (R6G) for preparing various concentration respectively is molten
Liquid is analyzed as sample, the spectrophotometer of Application Example 1, is shot and is gone under the same conditions using smart phone
Ionized water reagent and the corresponding spectrogram of various concentration rhodamine liquor, as shown in figure 5, spectral intensity figure is converted into spectrum again
Curve (Fig. 6).520nm corresponding to sample, which absorbs, calculates various concentration solution by Beer-Lambert theorem under response wave length
Compared to the absorbance of empty sample solvent, can be analyzed by the absorbance value corresponding to various concentration concentration and absorbance it
Between linear response relationship.Fig. 7 shows the linear response coefficient between the rhodamine liquor of various concentration and absorbance
0.998, the present invention is shown to the sensitive response relation of sample concentration variation.
Embodiment 5:
It is handled using Elisa method containing the sample of avian influenza virus (AIV), it will be through by avian influenza virus (AIV) sample
Product are according to 1 × 103,5×103,1×104,5×104,1×105,5×105After multiple is diluted, point of embodiment 1 is used
Light photometer measures the absorbance of the reaction product through enzyme-linked tag, establishes linear between sample concentration and absorbance
Fit correlation, linear coefficient value are 0.988.Meanwhile the microplate reader of business having been used to measure identical sample solution,
Obtaining the linear fit coefficient between sample concentration and absorbance is 0.986.Show the present invention and common business by comparison
The accuracy of spectrophotometer detecting instrument is quite (Fig. 8).
Although the present invention has been described by way of example and in terms of the preferred embodiments, it is not intended to limit the invention, any to be familiar with this skill
The people of art can do various change and modification, therefore protection model of the invention without departing from the spirit and scope of the present invention
Enclosing subject to the definition of the claims.
Claims (10)
1. a kind of portable spectrophotometer, which is characterized in that including total reflective mirror, collector lens and beam splitting system；It is described to be all-trans
The total length of optical axis locating for mirror, collector lens and beam splitting system is no more than 120mm；The beam splitting system include optical filtering pin hole,
Short focal length lens, spectro-grating.
2. portable spectrophotometer according to claim 1, which is characterized in that the optical filtering pin hole setting is saturating in optically focused
The focal point of mirror, filter out other than converged light in astigmatism；The collector lens is optically focused biconvex lens.
3. portable spectrophotometer according to claim 1 or 2, which is characterized in that the spectrophotometer also contains
The region of planchet is placed, which is arranged before total reflective mirror.
4. any portable spectrophotometer according to claim 1~3, which is characterized in that the spectrophotometer is suitable
The spectrum intensity range of light source is in visible light 350nm-800nm.
5. portable spectrophotometer according to any one of claims 1 to 4, which is characterized in that the table of the spectro-grating
The angle of face corner and optical axis can satisfy in 26 ° of -28 ° of directions clockwise only allows first-order diffraction spectral reflectance to smart phone
In the field range of rear camera.
6. a kind of method for detecting absorbance, which is characterized in that using any spectrophotometer of Claims 1 to 5, match
The smart phone with camera function is closed, the abosrption spectrogram that spectrophotometer is presented is acquired by smart phone, and pass through fortune
Spectrum picture is converted absorbance data by calculation method.
7. according to the method described in claim 6, it is characterized in that, the operation method includes the following steps:
(1) number for selecting calibration point, demarcates the relationship between pixel position and wavelength；
(2) reading that the laser calibration point that shooting obtains carries out respective pixel position is chosen；
(3) calibration maps read end post analysis and obtain the pixel of imaging system and the corresponding linear relationship curve of wavelength；
(4) absorption spectrum curve can be converted by reading any obtained sample absorption spectra line chart that shoots.
8. method according to claim 6 or 7, which is characterized in that also set up the linear equation of absorbance and sample concentration.
9. a kind of spectrophotomelric assay device, which is characterized in that including any portable light splitting light of Claims 1 to 5
Degree meter and it is matched use have take pictures, the smart phone of calculation function.
10. any portable spectrophotometer of Claims 1 to 5 is in biology, medical treatment, agricultural, chemical analysis field
Application.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910392713.XA CN110118750A (en) | 2019-05-13 | 2019-05-13 | Hand-held spectrophotometer based on smart phone |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201910392713.XA CN110118750A (en) | 2019-05-13 | 2019-05-13 | Hand-held spectrophotometer based on smart phone |
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| CN110118750A true CN110118750A (en) | 2019-08-13 |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2766702A2 (en) * | 2011-10-12 | 2014-08-20 | Nico Correns | Miniaturized optoelectronic system for spectral analysis |
| CN107084790A (en) * | 2017-04-24 | 2017-08-22 | 西安交通大学 | Portable spectrometer and its spectral method of detection based on smart mobile phone |
| CN108151877A (en) * | 2017-12-14 | 2018-06-12 | 西京学院 | A kind of micro-hole spectrometer and spectrum reconstruction method |
| CN108731805A (en) * | 2017-04-14 | 2018-11-02 | 中山大学 | Absorption based on mobile intelligent terminal and fluorescence spectrum detecting device |
| CN109211415A (en) * | 2018-11-20 | 2019-01-15 | 电子科技大学 | A kind of Wavelength calibration method based on light source light spectrum characteristic wavelength |
-
2019
- 2019-05-13 CN CN201910392713.XA patent/CN110118750A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2766702A2 (en) * | 2011-10-12 | 2014-08-20 | Nico Correns | Miniaturized optoelectronic system for spectral analysis |
| CN108731805A (en) * | 2017-04-14 | 2018-11-02 | 中山大学 | Absorption based on mobile intelligent terminal and fluorescence spectrum detecting device |
| CN107084790A (en) * | 2017-04-24 | 2017-08-22 | 西安交通大学 | Portable spectrometer and its spectral method of detection based on smart mobile phone |
| CN108151877A (en) * | 2017-12-14 | 2018-06-12 | 西京学院 | A kind of micro-hole spectrometer and spectrum reconstruction method |
| CN109211415A (en) * | 2018-11-20 | 2019-01-15 | 电子科技大学 | A kind of Wavelength calibration method based on light source light spectrum characteristic wavelength |
Non-Patent Citations (1)
| Title |
|---|
| LI-JU WANG 等: "Smartphone Optosensing Platform Using a DVD Grating to Detect Neurotoxins", 《ACS SENSORS》 * |
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