CN110114366A - 双膦酸喹诺酮缀合物及其用途 - Google Patents

双膦酸喹诺酮缀合物及其用途 Download PDF

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Publication number
CN110114366A
CN110114366A CN201780048088.6A CN201780048088A CN110114366A CN 110114366 A CN110114366 A CN 110114366A CN 201780048088 A CN201780048088 A CN 201780048088A CN 110114366 A CN110114366 A CN 110114366A
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CN
China
Prior art keywords
substituted
group
bone
aryl
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201780048088.6A
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English (en)
Chinese (zh)
Inventor
弗兰克·H·埃贝蒂诺
舒廷·孙
马克·W·伦迪
查尔斯·E·麦克纳
埃里克·理查德
帕里什·塞吉扎德
凯万·萨德拉菲
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baiaowei Bone Co Ltd
University of Southern California USC
Original Assignee
Baiaowei Bone Co Ltd
University of Southern California USC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baiaowei Bone Co Ltd, University of Southern California USC filed Critical Baiaowei Bone Co Ltd
Publication of CN110114366A publication Critical patent/CN110114366A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)
CN201780048088.6A 2016-06-03 2017-06-02 双膦酸喹诺酮缀合物及其用途 Pending CN110114366A (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201662345370P 2016-06-03 2016-06-03
US62/345,370 2016-06-03
US201662357727P 2016-07-01 2016-07-01
US62/357,727 2016-07-01
US201762448060P 2017-01-19 2017-01-19
US62/448,060 2017-01-19
PCT/US2017/035764 WO2017210611A1 (en) 2016-06-03 2017-06-02 Bisphosphonate quinolone conjugates and uses thereof

Publications (1)

Publication Number Publication Date
CN110114366A true CN110114366A (zh) 2019-08-09

Family

ID=60479075

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201780048088.6A Pending CN110114366A (zh) 2016-06-03 2017-06-02 双膦酸喹诺酮缀合物及其用途

Country Status (4)

Country Link
EP (1) EP3464307A4 (https=)
JP (3) JP7602217B2 (https=)
CN (1) CN110114366A (https=)
WO (1) WO2017210611A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112533612A (zh) * 2018-06-26 2021-03-19 弗兰克·哈洛克·埃比蒂诺 骨靶向抗微生物噁唑烷酮相关化合物、其制剂及其用途

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017210611A1 (en) * 2016-06-03 2017-12-07 Biovinc, Llc. Bisphosphonate quinolone conjugates and uses thereof
KR20180115979A (ko) * 2017-04-14 2018-10-24 연세대학교 산학협력단 비스포스포네이트를 포함하는 만성 이식신 기능부전 예방 또는 치료용 조성물

Citations (4)

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CN1057654A (zh) * 1990-06-25 1992-01-08 武田药品工业株式会社 双膦酸衍生物及其制备和应用
AU4813797A (en) * 1996-10-09 1998-05-05 Elizanor Biopharmaceuticals, Inc. Diphosphonate therapeutic compounds
CN101300248A (zh) * 2005-04-21 2008-11-05 塔甘塔治疗公司 膦酸酯化的氟喹诺酮、其抗菌类似物以及预防和治疗骨和关节感染的方法
CN101460059A (zh) * 2006-05-12 2009-06-17 加利福尼亚大学董事会 用于细菌感染的抗微生物疗法

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US4921475A (en) 1983-08-18 1990-05-01 Drug Delivery Systems Inc. Transdermal drug patch with microtubes
US5087240A (en) 1983-08-18 1992-02-11 Drug Delivery Systems Inc. Transdermal drug patch with conductive fibers
US5163899A (en) 1987-03-20 1992-11-17 Drug Delivery Systems Inc. Transdermal drug delivery system
US5312325A (en) 1987-05-28 1994-05-17 Drug Delivery Systems Inc Pulsating transdermal drug delivery system
GB8804164D0 (en) 1988-02-23 1988-03-23 Tucker J M Bandage for administering physiologically active compound
US5008110A (en) 1988-11-10 1991-04-16 The Procter & Gamble Company Storage-stable transdermal patch
US5088977A (en) 1988-12-21 1992-02-18 Drug Delivery Systems Inc. Electrical transdermal drug applicator with counteractor and method of drug delivery
DK0431519T3 (da) 1989-12-04 1994-07-04 Searle & Co System til transdermal indgivelse af albuterol
US5352456A (en) 1991-10-10 1994-10-04 Cygnus Therapeutic Systems Device for administering drug transdermally which provides an initial pulse of drug
DE69228827T2 (de) 1991-12-18 1999-10-21 Minnesota Mining And Mfg. Co., Saint Paul Mehrschichtige sperrstrukturen
ATE132381T1 (de) 1992-01-29 1996-01-15 Voelkl Franz Ski Ballspielschläger, insbesondere tennisschläger
FI945595A7 (fi) * 1992-05-29 1994-11-28 Procter & Gamble Pharmaceuticals Inc Tiosubstituoituja typpipitoisia heterosyklisiä fosfonaattiyhdisteitä e pänormaalin kalsium- ja fosfaattiaineenvaihdunnan hoitamiseksi
US8586781B2 (en) * 1998-04-02 2013-11-19 Mbc Pharma, Inc. Bone targeted therapeutics and methods of making and using the same
CL2007003332A1 (es) * 2006-11-24 2008-06-20 Actelion Pharmaceuticals Ltd Compuestos derivados de heterociclos condensados; compuestos intermediarios; composicion farmaceutica; y uso en la prevencion o tratamiento de infecciones bacterianas.
WO2010071826A2 (en) * 2008-12-19 2010-06-24 University Of Florida Research Foundation, Inc. Methods for treating osteoclast-related disease, compounds and compositions thereof
US20140051652A1 (en) * 2012-08-20 2014-02-20 Kingsley Yianomah Quartey Treatment for Migraine Headache
WO2017210611A1 (en) * 2016-06-03 2017-12-07 Biovinc, Llc. Bisphosphonate quinolone conjugates and uses thereof

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1057654A (zh) * 1990-06-25 1992-01-08 武田药品工业株式会社 双膦酸衍生物及其制备和应用
AU4813797A (en) * 1996-10-09 1998-05-05 Elizanor Biopharmaceuticals, Inc. Diphosphonate therapeutic compounds
US6333424B1 (en) * 1996-10-09 2001-12-25 Eliza Nor Biopharmaceuticals, Inc. Therapeutic derivatives of diphosphonates
CN101300248A (zh) * 2005-04-21 2008-11-05 塔甘塔治疗公司 膦酸酯化的氟喹诺酮、其抗菌类似物以及预防和治疗骨和关节感染的方法
CN101460059A (zh) * 2006-05-12 2009-06-17 加利福尼亚大学董事会 用于细菌感染的抗微生物疗法

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112533612A (zh) * 2018-06-26 2021-03-19 弗兰克·哈洛克·埃比蒂诺 骨靶向抗微生物噁唑烷酮相关化合物、其制剂及其用途

Also Published As

Publication number Publication date
CA3028343A1 (en) 2017-12-07
JP2019518792A (ja) 2019-07-04
EP3464307A4 (en) 2020-01-22
JP2023181185A (ja) 2023-12-21
EP3464307A1 (en) 2019-04-10
JP7602217B2 (ja) 2024-12-18
WO2017210611A1 (en) 2017-12-07
JP2022166008A (ja) 2022-11-01

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