CN110090364A - A kind of adherent rechargeable ultrasonic positive inotropic therapeutic device - Google Patents
A kind of adherent rechargeable ultrasonic positive inotropic therapeutic device Download PDFInfo
- Publication number
- CN110090364A CN110090364A CN201910362076.1A CN201910362076A CN110090364A CN 110090364 A CN110090364 A CN 110090364A CN 201910362076 A CN201910362076 A CN 201910362076A CN 110090364 A CN110090364 A CN 110090364A
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- Prior art keywords
- rechargeable
- ultrasonic
- piezo
- adherent
- positive inotropic
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N2007/0004—Applications of ultrasound therapy
Abstract
The invention discloses a kind of adherent rechargeable ultrasonic positive inotropic therapeutic devices, including ultrasound wave irradiation probe, integration module and the rechargeable display control panel being sequentially connected electrically；The inverter and supersonic generator of electrical connection are embedded in integration module；Ultrasound wave irradiation probe is internal to be embedded ultrasonic transducer；Ultrasonic transducer and supersonic generator electrical connection；Ultrasonic transducer includes several piezo-electric crystals, and each piezo-electric crystal is distributed on flexible plates at circle out shape, is connected in series between each piezo-electric crystal with conducting wire；The upper and lower surface of piezo-electric crystal is connect with electrode；The lower end of piezo-electric crystal is successively arranged matching layer and sound transmitting window；A temperature sensor connecting with display controller is embedded on the inward flange center of sound transmitting window；Rechargeable display control panel is equipped with several control buttons connecting with display controller.
Description
Technical field
The invention belongs to the technical fields of medical device, and in particular to a kind of adherent rechargeable ultrasonic positive inotropic treatment dress
It sets.
Background technique
Research shows that ultrasonic irradiation, which has, changes cardiac muscle and Skeletal Muscle Cell membrane permeability and the transhipment of muscular strength relevant ions
The function in channel, to influence cardiac muscle and skeletal muscle cell membrane depolarization and process of repolarization, and intracellular muscular strength correlation Ca++Ion
Concentration distribution, and influence muscle fibril contractile function in cardiac muscle and Skeletal Muscle Cell and different muscular strengths is caused to change.Using super
Sound wave irradiation is possible to generate two opposite myodyamia effects, it may be assumed that it can both enhance the contractile function of cardiac muscle and Skeletal Muscle Cell,
It is possible that lowering the contractile function of cardiac muscle and Skeletal Muscle Cell.
And existing ultrasonic positive inotropic therapeutic device cannot fit closely together with physical feeling is illuminated, and cause to surpass
Acoustic attenuation, so that therapeutic effect differs greatly with expection.
Summary of the invention
It is an object of the invention to be directed to above-mentioned deficiency in the prior art, a kind of adherent rechargeable ultrasonic positivity flesh is provided
Power therapeutic device, to solve or improve the above problem.
In order to achieve the above objectives, the technical solution adopted by the present invention is that:
A kind of adherent rechargeable ultrasonic positive inotropic therapeutic device comprising drive line to be sequentially connected electrically by usb data
Ultrasound wave irradiation probe, integration module and rechargeable display control panel；
The inverter and supersonic generator of electrical connection are embedded in integration module；Ultrasound wave irradiation probe is internal to be embedded ultrasound
Energy converter；Ultrasonic transducer and supersonic generator electrical connection；Be integrated in rechargeable display control panel display controller and
Rechargeable power supply；Display controller is connect with ultrasonic generator and rechargeable power supply respectively；
Ultrasonic transducer includes several piezo-electric crystals, and each piezo-electric crystal be distributed at circle out shape it is flexible
On plates, it is connected in series between each piezo-electric crystal with conducting wire；The upper and lower surface of piezo-electric crystal is connect with electrode；Piezoelectricity
The lower end of crystal is successively arranged matching layer and sound transmitting window；One is embedded on the inward flange center of sound transmitting window to control with display
The temperature sensor of device connection processed；Rechargeable display control panel is equipped with several control buttons connecting with display controller.
Preferably, display controller is arm processor.
The uniform full-filling in end for being preferably located at ultrasound wave irradiation probe has sound-absorbing material.
Preferably, sound transmitting window is convex lens or concavees lens.
Preferably, the lower section of piezo-electric crystal is at least provided with one layer of matching layer.
Preferably, temperature sensor is KW-WDCGQ micro temperature sensor, having a size of 0.5mm × 0.5mm.
Preferably, the frequency for the ultrasonic wave that inverter, ultrasonic generator and ultrasonic transducer issue is 3.6Mhz-5Mhz,
Intensity is 1w/cm2-3w/cm2。
Adherent rechargeable ultrasonic positive inotropic therapeutic device provided by the invention, has the advantages that
Ultrasonic transducer is independently disposed in ultrasound wave irradiation probe by the present invention, and multiple piezo-electric crystals are distributed in a ring
In the feasibility that the three-dimension curved surface on concentric circles, improved in human body exposed portion freely adjusts, apparatus of the present invention is promoted to be more convenient for
It is fixed in body part surface in need for the treatment of, in order to continued treatment；Make ultrasound wave irradiation probe simultaneously and is illuminated body
Body region fits closely together, reduces ultrasonic attenuation, improves therapeutic effect.
Detailed description of the invention
Fig. 1 is the structure chart of adherent rechargeable ultrasonic positive inotropic therapeutic device.
Fig. 2 is the functional block diagram of adherent rechargeable ultrasonic positive inotropic therapeutic device.
Fig. 3 is the functional block diagram of adherent rechargeable ultrasonic positive inotropic therapeutic device.
Fig. 4 is that the beasle dog of adherent rechargeable ultrasonic positive inotropic therapeutic device opens chest ultrasound wave irradiation experimental result picture.
Fig. 5 is adherent rechargeable ultrasonic positive inotropic therapeutic device basis cardiomyocytes irradiation experiment.
Fig. 6 is adherent rechargeable ultrasonic positive inotropic therapeutic device isolated skeletal muscle group irradiation experiment.
Fig. 7 is that adherent rechargeable ultrasonic positive inotropic therapeutic device beasle dog opens the experiment of chest heart in vivo ultrasound wave irradiation.
Wherein, 1, ultrasonic transducer；2, ultrasonic generator；3, display controller；4, temperature sensor；5, inverter；6,
Rechargeable power supply；7, integration module；8, conducting wire；9, usb data drives line；10, sound-absorbing material；11, electrode；12, piezo-electric crystal；
13, matching layer；14, sound transmitting window；15, rechargeable display control panel.
Specific embodiment
A specific embodiment of the invention is described below, in order to facilitate understanding by those skilled in the art this hair
It is bright, it should be apparent that the present invention is not limited to the ranges of specific embodiment, for those skilled in the art,
As long as various change is in the spirit and scope of the present invention that the attached claims limit and determine, these variations are aobvious and easy
See, all are using the innovation and creation of present inventive concept in the column of protection.
According to one embodiment of the application, with reference to Fig. 1, the adherent rechargeable ultrasonic positive inotropic treatment dress of this programme
It sets, including ultrasound wave irradiation probe, integration module 7 and the rechargeable display control face for driving line 9 to be sequentially connected electrically by usb data
Plate 15, usb data drive line 9 for realizing the supply of power supply and the transmission of data.
Wherein, integration module 7 can be fixed on rechargeable 15 back of display control panel, or by rechargeable display control
Panel 15 is fixed on integration module 7, and two structures are fixed together, to carry and to operate.
Meanwhile the present invention is independent at single structure by ultrasound wave irradiation probe, can effectively reduce weight of equipment, make ultrasound wave irradiation
Probe is in close contact with back patient exposure, avoids ultrasonic attenuation, and compressing that will not be overweight is in patient.Convenient for the same of operation
When, also increase the therapeutic effect of ultrasonic wave.
Ultrasound wave irradiation probe, integration module 7 and rechargeable display control panel 15 are described in detail below.
With reference to Fig. 3, ultrasound wave irradiation probe is internal to be embedded with ultrasonic transducer 1 by the way that pcb board is integrated, and integration module 7 is embedded
Inverter 5 and supersonic generator equipped with electrical connection；Ultrasonic transducer 1 and supersonic generator electrical connection.
Display controller 3 and rechargeable power supply 6 are integrated in rechargeable display control panel 15；Display controller 3 is distinguished
It is connect with ultrasonic generator 2 and rechargeable power supply 6；2 input terminal of ultrasonic generator successively connects with inverter 5 and rechargeable power supply 6
It connects, output end is connect with ultrasonic transducer 1.
With reference to Fig. 2, ultrasonic transducer 1 includes several piezo-electric crystals 12, several piezo-electric crystals 12 are distributed in a ring
On at least two concentric circles, and each piezo-electric crystal 12 is distributed on flexible plates at circle out shape, each piezo crystals
It is connected in series between body 12 with conducting wire 8.
Circular piezo-electric crystal 12 is selected, and setting that piezo-electric crystal 12 is arranged in a ring, is irradiated for improving in human body
The feasibility that partial three-dimension curved surface freely adjusts, so that apparatus of the present invention are more convenient for being fixed on physical feeling table in need for the treatment of
On face, in order to continued treatment；It fits closely ultrasound wave irradiation probe together with physical feeling is illuminated, reduces super
Acoustic attenuation improves therapeutic effect.
Piezo-electric crystal 12 is one of core element, for emitting ultrasonic wave, by piezoelectric single crystal by certain way and centainly
Direction cutting is formed or is made of piezoelectric ceramics through polarization.
The upper and lower surface of piezo-electric crystal 12 is connect with electrode 11, and electrode 11 is the silver layer of 12 two sides of piezo-electric crystal covering,
Purpose is that the voltage that makes to supply on piezo-electric crystal 12 is uniform, and the electrode 11 of 12 upper surface of piezo-electric crystal line of starting to exchange fire leads to circuit, bottom
Face, which is then grounded, to connect with the common point of circuit to be formed into a loop.
The lower end of piezo-electric crystal 12 is successively arranged matching layer 13 and sound transmitting window 14.Wherein, sound transmitting window 14 is convex lens or recessed
Lens, the wave beam for issuing ultrasonic transducer 1 focus, and meet the specific requirements at ultrasound wave irradiation position.
Matching layer 13 is at least arranged one layer, the number of plies according to the actual situation depending on, due to human skin and piezo-electric crystal 12
The acoustic characteristic impedance of material differs greatly, to solve the acoustical match between skin and 12 material of piezo-electric crystal, in front of chip
One or more layers matching layer 13 need to be added.
Uniform full-filling has sound-absorbing material 10 on probing shell, and sound-absorbing material 10 is obturator-type foamed plastics, radiates backward
Sound energy almost all sponge, with after eliminating to interference.Sound-absorbing material 10 is also the damping material that piezo-electric crystal 12 vibrates, with
Shorten the vibration period.
A temperature sensor 4 connecting with display controller 3 is embedded on the inward flange center of sound transmitting window 14
Temperature sensor 4 is KW-WDCGQ micro temperature sensor 4, having a size of 0.5mm × 0.5mm.
During ultrasound wave irradiation, since energy will appear decaying, a part of acoustic wave energy meeting in the transmittance process of sound wave
It is transformed into thermal energy, so as to cause the raising of cardiac muscle and skeletal muscle temperature.It is existing research shows that when ultrasound generate energy in biology
It is used to improve differentiation heating in movable (< 44 DEG C) range, the shrinkage of cardiac muscle and skeletal muscle can be improved.Work as ultrasonic wave
Chronic exposure cardiac muscle and skeletal muscle, cardiac muscle and skeletal muscle can persistently overheatings.If cardiac muscle and skeletal muscle constant temperature increase and surpass
Certain threshold value is crossed, then ultrasound wave irradiation can generate side effect.Therefore, using 4 real-time monitoring temperature of KW-WDCGQ micro temperature sensor
The variation of degree is that ultrasound wave irradiation treats the safety condition that must be taken into consideration by temperature control in biological activity is enclosed safely.
And in ultrasound wave irradiation therapeutic process, which, which can be monitored in real time in ultrasonic radiation therapeutic process, surpasses
Acoustically radiating passes through display control panel set temperature threshold value according to the temperature popped one's head in human body surface contact position, once temperature
It more than threshold value, is alarmed by the display screen on rechargeable display control panel 15, type of alarm can be raised by built-in
Sound device gives a warning, while display screen flashes, and warning current temperature value has exceeded preset value, it should stop ultrasonic wave in time
Treatment, it is known that temperature is down in the value range of normal temperature.
Rechargeable display control panel 15 is equipped with several control buttons connecting with display controller 3.Wherein, display control
Device 3 processed is arm processor.
Several control buttons are embedded with or are integrated on rechargeable display control panel 15, including power switch, irradiation open
Dynamic and shutdown switch, irradiation time setting button, ultrasound emission frequency regulating key, ultrasonic power regulating key and threshold value temperature
Degree setting.
During radiation treatment, after rechargeable display controller 33 starts, irradiation time, tranmitting frequency, transmission power,
Threshold temperature is disposed as default value, can be respectively to parameters such as irradiation time, tranmitting frequency, threshold temperatures if any specific demand
It is configured.
Wherein, the frequency for the ultrasonic wave that inverter 55, ultrasonic generator 22 and ultrasonic transducer 11 issue is 3.6Mhz-
5Mhz, intensity 1w/cm2-3w/cm2。
Apparatus of the present invention for a long time surpass cardiac muscle and skeletal muscle primarily directed to the patient for having specific demand, through body surface
Sound radiation treatment, to achieve the purpose that enhancing cardiac muscle and Skeletal Muscle Contraction function.Its action principle is, when ultrasonic transducer is sent out
When the energy that ultrasonic wave out is adjusted to them is enough to penetrate cardiac muscle and bone, the function of sound wave can be by generating low temperature
Heating, microcirculation change, excitation, stable cavitation, miniflow or chemical effect etc. play their effect.Due to ultrasound it is this
Known attribute, cardiac muscle and skeletal muscle tissue will absorb this differentiation heating according to the viscosity of their own.In this way, cardiac muscle and
More energy can be absorbed than cytoplasm in cell membrane in skeletal muscle.Therefore, the sarcoplasmic reticulum in cardiac muscle and Skeletal Muscle Cell will
Energy is absorbed prior to cytoplasm and is heated.To cause cardiac muscle and Skeletal Muscle Cell membrane permeability and muscular strength ion transport logical
Road function changes, and influences cardiac muscle Ca related to process of repolarization and intracellular muscular strength to skeletal muscle cell membrane depolarization++Ion
Concentration distribution.Exactly this biological effect influences muscle fibril contractile function in cardiac muscle and Skeletal Muscle Cell and causes different
Muscular strength changes.
Ultrasonic irradiation device of the present invention is characterized mainly in that using specific ultrasonic irradiation parameter to the heart
Flesh or skeletal muscle carry out ultrasound wave irradiation treatment, induce the positive inotropic of cardiac muscle and skeletal muscle.
Since different ultrasonic irradiation frequencies, different ultrasonic powers induce the effect of cardiac muscle and skeletal muscle positive inotropic
It differs greatly, the ultrasonic irradiation of inappropriate frequency and power can play opposite effect instead, or even lower cardiac muscle and bone
Flesh muscular strength.Therefore, ultrasonic irradiation frequency, intensity of acoustic wave, the selection of irradiation time treat ultrasound wave irradiation most important.By
Experiments have shown that it is found that ultrasonic irradiation induces cardiac muscle and the best frequency of sound wave of skeletal muscle positive inotropic is 3.6Mhz-5Mhz,
Intensity of acoustic wave is 1w/cm2-3w/cm2, irradiation time (4min-6min), 37 DEG C of temperature threshold etc..
It is irradiated by basic cardiomyocytes real with reference to Fig. 4-Fig. 7 using ultrasound wave irradiation parameter proposed by the present invention
It tests, isolated skeletal muscle group irradiation experiment and beasle dog open chest heart in vivo ultrasound wave irradiation it is demonstrated experimentally that Assessment of Left Ventricular Systolic Function increases
Most obvious by force, aortic blood flow increases, and improves heart and integrally does work, and shows that this method is more advantageous to induction cardiac muscle and bone
Flesh generates positive inotropic, while reducing a possibility that negative inotropic action generates.
According to one embodiment of the application, the following are making for the adherent rechargeable ultrasonic positive inotropic therapeutic device of the present invention
With method:
Step 1, on rechargeable display control panel 15, the frequency and function of ultrasonic wave transmitting are set by control button
Rate, it is ensured that the energy of super ultrasonic wave is enough to penetrate cardiac muscle and skeletal muscle；Concurrently set the critical value of temperature.
Step 2, medical staff's hand-held ultrasound irradiation probe irradiates the physical feeling for being illuminated treatment, and ultrasonic wave is held
Continuous irradiation cardiac muscle and skeletal muscle, so that its Surface skin temperature persistently rises.
Step 3, it when temperature is more than the threshold value of setting, alarms on rechargeable display control panel 15, medical staff
Stop the irradiation to cardiac muscle and skeletal muscle (or the generation for stopping ultrasonic wave being controlled by display controller 3), until temperature drops
When in down to normal temperature range, ultrasonic irradiation is continued starting.
The present invention is independent at single structure by ultrasound wave irradiation probe, can effectively reduce weight of equipment, ultrasound wave irradiation is made to pop one's head in
It is in close contact with back patient exposure, avoids ultrasonic attenuation, and compressing that will not be overweight is in patient.While convenient for operation,
Increase the therapeutic effect of ultrasonic wave.
Ultrasonic transducer 1 is independently disposed in ultrasound wave irradiation probe by the present invention, and in a ring by multiple piezo-electric crystals 12
It is distributed on concentric circles, the feasibility that raising is freely adjusted in the three-dimension curved surface of human body exposed portion promotes apparatus of the present invention more
Convenient for being fixed in body part surface in need for the treatment of, in order to continued treatment；Make ultrasound wave irradiation probe simultaneously and by spoke
It is fitted closely together according to physical feeling, reduces ultrasonic attenuation, improve therapeutic effect.
Although being described in detail in conjunction with specific embodiment of the attached drawing to invention, should not be construed as to this patent
Protection scope restriction.In range described by claims, those skilled in the art are without creative work
The various modifications and deformation made still belong to the protection scope of this patent.
Claims (7)
1. a kind of adherent rechargeable ultrasonic positive inotropic therapeutic device, it is characterised in that: including driving line successively by usb data
Ultrasound wave irradiation probe, integration module and the rechargeable display control panel of electrical connection；
The inverter and supersonic generator of electrical connection are embedded in the integration module；The ultrasound wave irradiation probe is internal to be embedded
Ultrasonic transducer；The ultrasonic transducer and supersonic generator electrical connection；It is integrated in the rechargeable display control panel
Display controller and rechargeable power supply；The display controller is connect with ultrasonic generator and rechargeable power supply respectively；
The ultrasonic transducer includes several piezo-electric crystals, and each piezo-electric crystal be distributed at circle out shape it is flexible
On plates, it is connected in series between each piezo-electric crystal with conducting wire；The upper and lower surface of the piezo-electric crystal is connect with electrode；
The lower end of the piezo-electric crystal is successively arranged matching layer and sound transmitting window；It is embedded on the inward flange center of the sound transmitting window
There is a temperature sensor connecting with display controller；The rechargeable display control panel is equipped with several and display controller
The control button of connection.
2. adherent rechargeable ultrasonic positive inotropic therapeutic device according to claim 1, it is characterised in that: the display control
Device processed is arm processor.
3. adherent rechargeable ultrasonic positive inotropic therapeutic device according to claim 1, it is characterised in that: be located at described super
Acoustically radiating has sound-absorbing material according to the uniform full-filling in end of probe.
4. adherent rechargeable ultrasonic positive inotropic therapeutic device according to claim 1, it is characterised in that: the sound transmitting window
For convex lens or concavees lens.
5. adherent rechargeable ultrasonic positive inotropic therapeutic device according to claim 1, it is characterised in that: the piezo crystals
The lower section of body is at least provided with one layer of matching layer.
6. adherent rechargeable ultrasonic positive inotropic therapeutic device according to claim 1, it is characterised in that: the temperature passes
Sensor is KW-WDCGQ micro temperature sensor, having a size of 0.5mm × 0.5mm.
7. adherent rechargeable ultrasonic positive inotropic therapeutic device according to claim 1, it is characterised in that: the inversion
The frequency for the ultrasonic wave that device, ultrasonic generator and ultrasonic transducer issue is 3.6Mhz-5Mhz, intensity 1w/cm2-3w/cm2。
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| Application Number | Priority Date | Filing Date | Title |
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| CN201910362076.1A CN110090364B (en) | 2019-04-30 | 2019-04-30 | Wall-attached charging type ultrasonic positive inotropic treatment device |
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| CN201910362076.1A CN110090364B (en) | 2019-04-30 | 2019-04-30 | Wall-attached charging type ultrasonic positive inotropic treatment device |
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| CN110090364B CN110090364B (en) | 2021-12-21 |
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Cited By (1)
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| CN112604191A (en) * | 2020-12-14 | 2021-04-06 | 中国科学院深圳先进技术研究院 | Multi-focus ultrasonic wave generation device and method |
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| CN110090364B (en) | 2021-12-21 |
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