CN110090238A - A kind of novel Tibet-medicine Bath medical fluid zymotechnique - Google Patents

A kind of novel Tibet-medicine Bath medical fluid zymotechnique Download PDF

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Publication number
CN110090238A
CN110090238A CN201711384340.9A CN201711384340A CN110090238A CN 110090238 A CN110090238 A CN 110090238A CN 201711384340 A CN201711384340 A CN 201711384340A CN 110090238 A CN110090238 A CN 110090238A
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China
Prior art keywords
medical fluid
medicine
fermentation
tibet
novel
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Pending
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CN201711384340.9A
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Chinese (zh)
Inventor
吴金鹏
黄河
檀秀香
崔峰
岳萍
李迎新
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Institute of Biomedical Engineering of CAMS and PUMC
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Institute of Biomedical Engineering of CAMS and PUMC
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Priority to CN201711384340.9A priority Critical patent/CN110090238A/en
Publication of CN110090238A publication Critical patent/CN110090238A/en
Pending legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/13Coniferophyta (gymnosperms)
    • A61K36/14Cupressaceae (Cypress family), e.g. juniper or cypress
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/17Gnetophyta, e.g. Ephedraceae (Mormon-tea family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/282Artemisia, e.g. wormwood or sagebrush
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/45Ericaceae or Vacciniaceae (Heath or Blueberry family), e.g. blueberry, cranberry or bilberry
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10Preparation or pretreatment of starting material
    • A61K2236/19Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

This is bright to provide a kind of novel Tibet-medicine Bath medical fluid fermentation preparation, and it is the Tibetan medicine fermentation raw material of auxiliary material that it, which is prepared using five tastes sweet dew side as main ingredient, highland barley, and the mass ratio of main ingredient and auxiliary material is 3:1.Medical fluid fermentation is soaking, cook, fermentation, collects 4 processes, the present invention is based on Tibetan medicine's tradition dip fermentation process, the improvement and optimization for carrying out Tibetan medicine bath foam zymotechnique are obviously shortened medical fluid manufacturing cycle by reasonably selecting fermentation parameter, are conducive to the development and popularization of Tibet-medicine Bath.

Description

A kind of novel Tibet-medicine Bath medical fluid zymotechnique
Technical field
The present invention relates to a kind of novel Tibet-medicine Bath medical fluid zymotechnique fields, more particularly to using Tibetan medicine as the fermentation of raw material Technique.
Background technique
Tibet-medicine Bath is the important means of Tibetan medicine's external therapy, a variety of to apoplexy sequela, rheumatism etc. chronic doubtful Difficult curative effect of disease is significant.When medical fluid acts on skin or affected part, the warm stimulation of generation can stimulate cutaneous nerve tip sense Receiver expands blood vessel, promotes blood and Lymphatic Circulation, accelerates metabolism, improves tissue and supports condition, generates to a variety of diseases Positive therapeutic effect.
Tibet-medicine Bath side based on " five tastes sweet dew " carries out medicated bath with card increase and decrease other medicines.Its main technical flows packet Include diagnosis, prescription, medical fluid preparation, dipping are treated with links such as nursing wherein especially the most key with medical fluid technology of preparing is to influence The core link of Tibet-medicine Bath clinical efficacy.
Traditional medical fluid fermentation mainly uses room temperature aging process, and fermentation time is long (3 ~ 5 days), and process is cumbersome, time-consuming, It can not adapt to the application demand of modern clinic quickly, easy, safe.In recent years, being widely popularized with Tibetan medicine balneotherapy occurs The Tibet-medicine Bath medical fluid preparation methods of 3 kinds of improvement:Direct decocting method: by directly decocting five tastes sweet dew Tibetan medicine, needed for acquisition Medical fluid;It directly decocts joint Ethanol Method: the white wine of proper proportion being added on the basis of directly decocting;Dissolution method: by the five tastes Sweet dew Tibetan medicine is made the dosage forms such as granule, paste, and when use is dissolved in water.Although these methods can greatly shorten Tibet-medicine Bath medical fluid Preparation time, but its quality of liquid medicine and traditional fermentation process still have larger gap, are the key factors for directly affecting medical fluid curative effect. In addition, traditional basic experience that relies on of Tibet-medicine Bath medical fluid fermentation is completed, unified standard is not formed, different batches medical fluid matter is caused There are larger differences for amount.
Summary of the invention
Technical solution of the present invention is intended to provide a kind of Tibet-medicine Bath medical fluid zymotechnique, it is with auxiliary materials such as Tibetan medicine and highland barleys Raw material, in particular to a kind of Tibet-medicine Bath medical fluid novel processing step.
The present invention provides a kind of novel Tibet-medicine Bath medical fluid fermentation preparations, it is comprised the steps of
(1) medicine and highland barley match: 3:1(mass ratio);(2) amount of water: 1:3(volume ratio 1/3 is impregnated);(3) soaking temperature: 37 C(25 C is more excellent);(4) soaking time: 4 h;(5) (truce when water surface is down to and did not just have Tibetan medicine) is decocted;(6) cooling temperature Degree: 31 C;(7) add strain class: distiller's yeast (the every kg medicine+highland barley dry weight of 8 g/);(8) fermentation temperature: 31 C;(9) fermentation time: 24 h;(10) medical fluid extracts: the medical fluid fermented being taken out, is added pure water (medicine/water volume ratio 1:3), is extracted 3 times altogether.
The invention has the benefit that the present invention based on Tibetan medicine's tradition dip fermentation process, carries out Tibetan medicine bath foam The improvement and optimization of zymotechnique are obviously shortened medical fluid manufacturing cycle by reasonably selecting fermentation parameter, are conducive to Tibet-medicine Bath Development and popularization.
Detailed description of the invention
Fig. 1 is flow diagram of the present invention.
Specific embodiment
The invention patent is described in further detail with reference to the accompanying drawing.
The specific embodiment of form by the following examples remakes further specifically above content of the invention It is bright.But the range that this should not be interpreted as to the above-mentioned theme of the present invention is only limitted to example below.It is all to be based on above content of the present invention The technology realized all belongs to the scope of the present invention.
Embodiment 1: medical fluid made of the raw material with the preparation of following ratio:
As shown in 1 flow chart of attached drawing: Tibetan medicine five tastes sweet dew side is with " four subsequent portions of doctor's allusion quotation ", " Tibetan medicine 18 ", " ten million Buddhist relics ", based on traditional ancient books and records such as " blue coloured glaze " Tibet-medicine Bath proved recipe, usage and the points for attention recorded, prepare that complete five sweet in flavor Dew side's main ingredient.Five tastes sweet dew side main ingredient is made of ephedra saxatilis Royle, German tamarisk, Sievers wormwood, Chinese juniper, chrysanthemum cuckoo.The quality of 5 kinds of Tibetan medicines Percentage is 20%, and five tastes sweet dew side main ingredient when fermentation preparation is 50 g every time.Specifically preparation method includes: with process
1. preparing the Tibetan medicine fermentation raw material using five tastes sweet dew side as main ingredient, highland barley for auxiliary material;2. the mass ratio of main ingredient and auxiliary material is 3:1.Medical fluid fermentation is soaking, cook, fermentation, collects 4 processes;3. Tibetan medicine impregnates: be added pure water in a medicament, Tibetan medicine with The volume ratio of water is 1:3, and temperature setting is 37 °;4. Tibetan medicine decocts: soaked Tibetan medicine being boiled, is down to the water surface and does not have just Cease fire when crossing Tibetan medicine surface.Temperature is cooled to 31 DEG C, every kg medicine+highland barley dry weight adds 8 g distiller's yeasts,;5. fermentation: will decoct Tibetan medicine naturally cool to 31 DEG C of fermentation temperature, and maintain the temperature until fermentation terminate for 24 hours;6. medical fluid extracts: will ferment Medical fluid take out, be added pure water water (liquid medicine volume ratio 1:3), altogether extract 3 times;7. liquid medicine collecting: the medical fluid collection that will be fermented Middle collection is easy to use.
By selection application, the selection application of Tibetan medicine usage ratio to Tibetan medicine raw material, different product can be made by fermentation The Tibet-medicine Bath medical fluid of kind and specification.
Obviously, above content according to the present invention is not being departed from according to the ordinary technical knowledge and customary means of this field Under the premise of the above-mentioned basic fundamental thought of the present invention, the modification, replacement or change of other diversified forms can also be made.

Claims (5)

1. a kind of novel Tibet-medicine Bath medical fluid fermentation preparation, which is characterized in that comprise the steps of, medical fluid fermentation it is soaking, It cooks, fermentation, collect 4 processes.
2. a kind of novel Tibet-medicine Bath medical fluid fermentation preparation according to claim 1, it is characterised in that the main ingredient and The mass ratio of auxiliary material is 3:1, and the Tibetan medicine impregnates: being added pure water in a medicament, the volume ratio of Tibetan medicine and water is 1:3, temperature It is set as 37 °.
3. a kind of novel Tibet-medicine Bath medical fluid fermentation preparation according to claim 1, it is characterised in that the Tibetan medicine is decocted It boils: soaked Tibetan medicine is boiled, temperature is cooled to 31 DEG C, every kg by the truce when water surface is down to just and did not had Tibetan medicine surface Medicine adds highland barley dry weight to add 8 g distiller's yeasts.
4. a kind of novel Tibet-medicine Bath medical fluid fermentation preparation according to claim 1, it is characterised in that the fermentation: will It decocts well-done Tibetan medicine and naturally cools to 31 DEG C of fermentation temperature, and maintain the temperature until carrying out medical fluid extraction after fermentation for 24 hours: The medical fluid fermented is taken out, is added pure water water (liquid medicine volume ratio 1:3), is extracted 3 times altogether.
5. a kind of novel Tibet-medicine Bath medical fluid fermentation preparation according to claim 1, it is characterised in that the medical fluid is received Collection: the medical fluid centralized collection that will be fermented is easy to use.
CN201711384340.9A 2017-12-20 2017-12-20 A kind of novel Tibet-medicine Bath medical fluid zymotechnique Pending CN110090238A (en)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112043742A (en) * 2020-10-14 2020-12-08 西藏阿秘达藏药有限责任公司 Pure natural medicinal bath lotion and its preparing process
CN112057492A (en) * 2020-10-14 2020-12-11 西藏阿秘达藏药有限责任公司 Pure natural foot bath effervescent pill and preparation process thereof
CN116059154A (en) * 2021-10-29 2023-05-05 李宏亮 Tibetan medicine eight-ingredient Heg bath composition

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104547988A (en) * 2014-12-10 2015-04-29 天祝藏族自治县藏医院 Tibetan medicine medicated bath for treating psoriasis and use method thereof
CN106729008A (en) * 2016-11-24 2017-05-31 拉孜县卫生服务中心 Treatment rheumatoid, skin disease, sciatica, the Tibetan medicine dip of osteoproliferation and its application

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104547988A (en) * 2014-12-10 2015-04-29 天祝藏族自治县藏医院 Tibetan medicine medicated bath for treating psoriasis and use method thereof
CN106729008A (en) * 2016-11-24 2017-05-31 拉孜县卫生服务中心 Treatment rheumatoid, skin disease, sciatica, the Tibetan medicine dip of osteoproliferation and its application

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112043742A (en) * 2020-10-14 2020-12-08 西藏阿秘达藏药有限责任公司 Pure natural medicinal bath lotion and its preparing process
CN112057492A (en) * 2020-10-14 2020-12-11 西藏阿秘达藏药有限责任公司 Pure natural foot bath effervescent pill and preparation process thereof
CN116059154A (en) * 2021-10-29 2023-05-05 李宏亮 Tibetan medicine eight-ingredient Heg bath composition

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Application publication date: 20190806

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