CN110075190A - The dedicated drug paste of dysmenorrhea - Google Patents
The dedicated drug paste of dysmenorrhea Download PDFInfo
- Publication number
- CN110075190A CN110075190A CN201910509120.7A CN201910509120A CN110075190A CN 110075190 A CN110075190 A CN 110075190A CN 201910509120 A CN201910509120 A CN 201910509120A CN 110075190 A CN110075190 A CN 110075190A
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- parts
- paste
- dysmenorrhea
- drug paste
- azone
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- 239000003814 drug Substances 0.000 title claims abstract description 51
- 229940079593 drug Drugs 0.000 title claims abstract description 45
- 206010013935 Dysmenorrhoea Diseases 0.000 title claims abstract description 29
- 208000005171 Dysmenorrhea Diseases 0.000 title claims abstract description 28
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 36
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims abstract description 17
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 claims abstract description 17
- AXTGDCSMTYGJND-UHFFFAOYSA-N 1-dodecylazepan-2-one Chemical compound CCCCCCCCCCCCN1CCCCCC1=O AXTGDCSMTYGJND-UHFFFAOYSA-N 0.000 claims abstract description 17
- 229940116229 borneol Drugs 0.000 claims abstract description 17
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 claims abstract description 17
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 claims abstract description 17
- 235000000604 Chrysanthemum parthenium Nutrition 0.000 claims abstract description 14
- 241000218176 Corydalis Species 0.000 claims abstract description 14
- 241000207925 Leonurus Species 0.000 claims abstract description 14
- 235000000802 Leonurus cardiaca ssp. villosus Nutrition 0.000 claims abstract description 14
- 244000020518 Carthamus tinctorius Species 0.000 claims abstract description 12
- 235000003255 Carthamus tinctorius Nutrition 0.000 claims abstract description 12
- 235000004204 Foeniculum vulgare Nutrition 0.000 claims abstract description 10
- 239000002994 raw material Substances 0.000 claims abstract description 9
- 240000006927 Foeniculum vulgare Species 0.000 claims abstract 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 15
- 235000019441 ethanol Nutrition 0.000 claims description 9
- 239000004820 Pressure-sensitive adhesive Substances 0.000 claims description 8
- 238000002156 mixing Methods 0.000 claims description 8
- 238000002360 preparation method Methods 0.000 claims description 7
- 238000000605 extraction Methods 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 6
- 238000010992 reflux Methods 0.000 claims description 6
- 230000008569 process Effects 0.000 claims description 5
- 239000003292 glue Substances 0.000 claims description 4
- 238000005336 cracking Methods 0.000 claims description 3
- 239000000284 extract Substances 0.000 claims description 3
- 239000012530 fluid Substances 0.000 claims description 3
- 239000012943 hotmelt Substances 0.000 claims description 3
- 239000002245 particle Substances 0.000 claims description 3
- 239000011241 protective layer Substances 0.000 claims description 3
- 238000004064 recycling Methods 0.000 claims description 3
- 238000007873 sieving Methods 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- 230000002035 prolonged effect Effects 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 12
- 208000002193 Pain Diseases 0.000 abstract description 10
- 239000011505 plaster Substances 0.000 abstract description 4
- 241000894006 Bacteria Species 0.000 abstract description 3
- 230000000146 antalgic effect Effects 0.000 abstract description 2
- 230000009286 beneficial effect Effects 0.000 abstract 1
- 241000212314 Foeniculum Species 0.000 description 6
- 230000000202 analgesic effect Effects 0.000 description 6
- 239000000463 material Substances 0.000 description 5
- 230000017531 blood circulation Effects 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 239000004615 ingredient Substances 0.000 description 4
- 230000001737 promoting effect Effects 0.000 description 4
- 230000008901 benefit Effects 0.000 description 3
- 230000000857 drug effect Effects 0.000 description 3
- 230000036541 health Effects 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 2
- 239000000730 antalgic agent Substances 0.000 description 2
- 230000003712 anti-aging effect Effects 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 230000002929 anti-fatigue Effects 0.000 description 2
- 230000003796 beauty Effects 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 238000009835 boiling Methods 0.000 description 2
- 230000004087 circulation Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 230000010534 mechanism of action Effects 0.000 description 2
- 230000035699 permeability Effects 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 206010000084 Abdominal pain lower Diseases 0.000 description 1
- 208000005641 Adenomyosis Diseases 0.000 description 1
- 201000009273 Endometriosis Diseases 0.000 description 1
- 201000009274 endometriosis of uterus Diseases 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000003821 menstrual periods Effects 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000001850 reproductive effect Effects 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/235—Foeniculum (fennel)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/286—Carthamus (distaff thistle)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/533—Leonurus (motherwort)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/66—Papaveraceae (Poppy family), e.g. bloodroot
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/714—Aconitum (monkshood)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
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- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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Abstract
The present invention provides the dedicated drug paste of dysmenorrhea, which is made of the raw material of following parts by weight: 15-35 parts of Radix Angelicae Sinensis, 6-20 parts of rhizoma corydalis, 20-30 parts of fructus lycii, 9-24 parts of fennel seeds, 3-18 parts of cortex cinnamomi, 25-40 parts of safflower, 3-6 parts of motherwort, 5-10 parts of glycerol, 10-15 parts of radix aconiti agrestis, 5-30 parts of borneol, 5-20 parts of azone.Beneficial effect is: the present invention by the effective component of antalgic in radix aconiti agrestis, motherwort by extracting and being fused in plaster, so that this dysmenorrhea medicine dedicated patch can be realized quickly alleviating pain in use, it is quick, using effect is good, it is fused in plaster by the way that Radix Angelicae Sinensis, fructus lycii, safflower etc. are had the effective component in dulcet Chinese medicine, it so that this drug paste can reduce the generation of peculiar smell when in use, and can effectively inhibit the growth of user paste section bacterium, improve the utilization rate of drug paste.
Description
Technical field
The invention belongs to dysmenorrhea treatment technical fields, more particularly, to the dedicated drug paste of dysmenorrhea.
Background technique
Dysmenorrhea is one of most common gynaecology's symptom, refers to before and after passing through or lower abdominal pain, falling inflation occurs in the menstrual period, with
The soreness of waist or other uncomfortable, serious symptom influence quality of life persons.Dysmenorrhea is divided into primary dysmenorrhea and secondary two class, primary pain
Through referring to dysmenorrhea of the reproductive organs without organic disease；Acquired dysmenorrhea refers to by pelvic cavity organic disease, as endometriosis,
Dysmenorrhea caused by adenomyosis etc..Generally in daily treatment dysmenorrhea, patient is more mainly by outer in order to quickly relieve pain
Anodyne is taken to realize analgesic, however it is larger to take anodyne side effect outside, and by using existing drug paste come when being treated,
Drug effect is slower, can not realize quick analgesic, and the peculiar smell of drug paste in use is larger, skin-care functional compared with
Difference is easy that patient is made to breed bacterium using position, is unfavorable for improving the utilization rate of drug paste, and increase user and infect other diseases
The risk of disease.
Summary of the invention
In view of this, the present invention is directed to propose the dedicated drug paste of dysmenorrhea.
In order to achieve the above objectives, the technical scheme of the present invention is realized as follows:
The dedicated drug paste of dysmenorrhea, the drug paste are made of the raw material of following parts by weight: the drug paste by following parts by weight raw material system
At: 15-35 parts of Radix Angelicae Sinensis, 6-20 parts of rhizoma corydalis, 20-30 parts of fructus lycii, 9-24 parts of fennel seeds, 3-18 parts of cortex cinnamomi, 25-40 parts of safflower,
3-6 parts of motherwort, 5-10 parts of glycerol, 10-15 parts of radix aconiti agrestis, 5-30 parts of borneol, 5-20 parts of azone.
Preferably, in the drug paste each raw material optimum weight part proportion are as follows: 20 parts of Radix Angelicae Sinensis, 12 parts of rhizoma corydalis, 25 parts of fructus lycii,
16 parts of fennel seeds, 10 parts of cortex cinnamomi, 32 parts of safflower, 4 parts of motherwort, 8 parts of glycerol, 12 parts of radix aconiti agrestis, 15 parts of borneol, 10 parts of azone, when
Return have effects that enrich blood, invigorate blood circulation, menstruction regulating and pain relieving, and have the function of antibacterial, rhizoma corydalis has the function of promoting blood circulation, promoting the circulation of qi, analgesic
It imitates, containing anti-aging, the ingredient that antifatigue and promotion is immune in fructus lycii, so that drug paste has health and beauty effect, cortex cinnamomi tool
There is the effect of middle benefit gas kidney tonifying, eliminating cold to stop pain, the effect for the treatment of can be further enhanced, contain Wen Jing in motherwort and radix aconiti agrestis
What is relieved pain is effective at ingredient, and the mechanism of action of the effective component is by making user's dysmenorrhea position temporary after drug absorption
It benumbs to realize quick gentle and quiet analgesic, glycerol has good dissolubility, the more uniform of each medicament mixing is enabled to, with
Just drug effect is fully played, borneol and azone have good permeability, enable to the effective component in drug paste sufficient
It penetrates into user's body, to realize that the colleges and universities of effective component in drug paste utilize, experiments have shown that added with azone and borneol
Utilization rate of active components in drug paste is up to 98%.
The preparation method of the dedicated drug paste of the dysmenorrhea, includes the following steps:
(1) rhizoma corydalis is crushed, and after sieving, alcohol reflux is added and extracts, after extracting recycling ethyl alcohol, by extraction
It is spare that rhizoma corydalis extracting solution is condensed into the paste that 50 DEG C of -70 DEG C of relative densities are 1-1.25；
(2) Radix Angelicae Sinensis, fructus lycii, fennel seeds, cortex cinnamomi, safflower, radix aconiti agrestis, motherwort are added into such as 5-6 times water progress measured after broken
It decocts, and the medical fluid after decoction is subjected to concentration extraction, paste is made, by the way that the medicinal material of each boiling is carried out break process, make
The effective component obtained in medicinal material can be extracted adequately；
(3) glycerol is added in the paste in step (1) and step (2) to be uniformly mixed, mixing is made
Paste；
(4) borneol and azone are added in the step (3) in mixing paste, and the paste is passed through into pressure sensitive adhesive glue
It is applied on rag, installs protective layer additional, the preparation of the drug paste can be completed.
Preferably, the relative concentration of ethyl alcohol is 70-80% in the step (1), and reflux proposes in the step (1)
Number is two, and the particle size after cracking of the step (2) is advisable with nearly powdery, and a length of 5-6 is small when decoction in the step (2)
When, the relative density of paste is 1.04 in the step (2), when 5-10 minutes a length of, the institute being mixed in the step (2)
It states borneol and azone in step (4) to be both needed to carry out break process before addition, pressure sensitive adhesive uses hot melt in the step (4)
Pressure sensitive adhesive is made.
Compared with the existing technology, the dedicated drug paste of dysmenorrhea of the present invention has the advantage that
1, the dedicated drug paste of dysmenorrhea of the present invention is by extracting simultaneously the effective component of antalgic in radix aconiti agrestis, motherwort
It is fused in plaster, so that this dysmenorrhea medicine dedicated patch can be realized quickly alleviating pain in use, quick, using effect
It is good；
2, the dedicated drug paste of dysmenorrhea of the present invention is by the way that Radix Angelicae Sinensis, fructus lycii, safflower etc. to have in dulcet Chinese medicine
Effective component is fused in plaster, so that this drug paste can reduce the generation of peculiar smell when in use, and can effectively inhibit user
The growth of paste section bacterium improves the utilization rate of drug paste；
3, the dedicated drug paste of dysmenorrhea of the present invention is made of pure natural medicinal material, and Small side effects can be used for daily
Uterus health care, it is easy to promote and utilize.
Specific embodiment
In addition to being defined, technical term used in following embodiment has universal with those skilled in the art of the invention
The identical meanings of understanding.
Below with reference to embodiment, the present invention will be described in detail.
The dedicated drug paste of dysmenorrhea, the drug paste are made of the raw material of following parts by weight: the drug paste by following parts by weight raw material system
At: 15-35 parts of Radix Angelicae Sinensis, 6-20 parts of rhizoma corydalis, 20-30 parts of fructus lycii, 9-24 parts of fennel seeds, 3-18 parts of cortex cinnamomi, 25-40 parts of safflower,
3-6 parts of motherwort, 5-10 parts of glycerol, 10-15 parts of radix aconiti agrestis, 5-30 parts of borneol, 5-20 parts of azone.
Preferably, in the drug paste each raw material optimum weight part proportion are as follows: 20 parts of Radix Angelicae Sinensis, 12 parts of rhizoma corydalis, 25 parts of fructus lycii,
16 parts of fennel seeds, 10 parts of cortex cinnamomi, 32 parts of safflower, 4 parts of motherwort, 8 parts of glycerol, 12 parts of radix aconiti agrestis, 15 parts of borneol, 10 parts of azone, when
Return have effects that enrich blood, invigorate blood circulation, menstruction regulating and pain relieving, and have the function of antibacterial, rhizoma corydalis has the function of promoting blood circulation, promoting the circulation of qi, analgesic
It imitates, containing anti-aging, the ingredient that antifatigue and promotion is immune in fructus lycii, so that drug paste has health and beauty effect, cortex cinnamomi tool
There is the effect of middle benefit gas kidney tonifying, eliminating cold to stop pain, the effect for the treatment of can be further enhanced, contain Wen Jing in motherwort and radix aconiti agrestis
What is relieved pain is effective at ingredient, and the mechanism of action of the effective component is by making user's dysmenorrhea position temporary after drug absorption
It benumbs to realize quick gentle and quiet analgesic, glycerol has good dissolubility, the more uniform of each medicament mixing is enabled to, with
Just drug effect is fully played, borneol and azone have good permeability, enable to the effective component in drug paste sufficient
It penetrates into user's body, to realize that the colleges and universities of effective component in drug paste utilize, experiments have shown that added with azone and borneol
Utilization rate of active components in drug paste is up to 98%.
The preparation method of the dedicated drug paste of the dysmenorrhea, includes the following steps:
(1) rhizoma corydalis is crushed, and after sieving, alcohol reflux is added and extracts, after extracting recycling ethyl alcohol, by extraction
It is spare that rhizoma corydalis extracting solution is condensed into the paste that 50 DEG C of -70 DEG C of relative densities are 1-1.25；
(2) Radix Angelicae Sinensis, fructus lycii, fennel seeds, cortex cinnamomi, safflower, radix aconiti agrestis, motherwort are added into such as 5-6 times water progress measured after broken
It decocts, and the medical fluid after decoction is subjected to concentration extraction, paste is made, by the way that the medicinal material of each boiling is carried out break process, make
The effective component obtained in medicinal material can be extracted adequately；
(3) glycerol is added in the paste in step (1) and step (2) to be uniformly mixed, mixing is made
Paste；
(4) borneol and azone are added in the step (3) in mixing paste, and the paste is passed through into pressure sensitive adhesive glue
It is applied on rag, installs protective layer additional, the preparation of the drug paste can be completed.
Preferably, the relative concentration of ethyl alcohol is 70-80% in the step (1), and reflux proposes in the step (1)
Number is two, and the particle size after cracking of the step (2) is advisable with nearly powdery, and a length of 5-6 is small when decoction in the step (2)
When, the relative density of paste is 1.04 in the step (2), when 5-10 minutes a length of, the institute being mixed in the step (2)
It states borneol and azone in step (4) to be both needed to carry out break process before addition, pressure sensitive adhesive uses hot melt in the step (4)
Pressure sensitive adhesive is made.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all in essence of the invention
Within mind and principle, any modification, equivalent replacement, improvement and so on be should all be included in the protection scope of the present invention.
Claims (4)
1. the dedicated drug paste of dysmenorrhea, it is characterised in that: the drug paste is made of the raw material of following parts by weight: 15-35 parts of Radix Angelicae Sinensis, rhizoma corydalis
6-20 parts, 20-30 parts of fructus lycii, 9-24 parts of fennel seeds, 3-18 parts of cortex cinnamomi, 25-40 parts of safflower, 3-6 parts of motherwort, glycerol 5-10
Part, 10-15 parts of radix aconiti agrestis, 5-30 parts of borneol, 5-20 parts of azone.
2. the dedicated drug paste of dysmenorrhea according to claim 1, it is characterised in that: optimum weight part of each raw material is matched in the drug paste
Than are as follows: 20 parts of Radix Angelicae Sinensis, 12 parts of rhizoma corydalis, 25 parts of fructus lycii, 16 parts of fennel seeds, 10 parts of cortex cinnamomi, 32 parts of safflower, 4 parts of motherwort, glycerol
8 parts, 12 parts of radix aconiti agrestis, 15 parts of borneol, 10 parts of azone.
3. the preparation method of the dedicated drug paste of dysmenorrhea of any of claims 1-2, it is characterised in that: including walking as follows
It is rapid:
(1) rhizoma corydalis is crushed, and after sieving, alcohol reflux is added and extracts, after extracting recycling ethyl alcohol, Hu is prolonged into extraction
It is spare that rope extracting solution is condensed into the paste that 50 DEG C of -70 DEG C of relative densities are 1-1.25；
(2) after being crushed Radix Angelicae Sinensis, fructus lycii, fennel seeds, cortex cinnamomi, safflower, radix aconiti agrestis, motherwort plus such as 5-6 times of water measured decocts,
And the medical fluid after decoction is subjected to concentration extraction, paste is made；
(3) glycerol is added in the paste in step (1) and step (2) to be uniformly mixed, mixing paste is made；
(4) borneol and azone are added in the step (3) in mixing paste, and the paste is smeared by pressure sensitive adhesive glue
On rag, installs protective layer additional, the preparation of the drug paste can be completed.
4. the preparation method of the dedicated drug paste of dysmenorrhea according to claim 3, it is characterised in that: ethyl alcohol in the step (1)
Relative concentration be 70-80%, the number that reflux proposes in the step (1) is two, the particle size after cracking of the step (2)
It is advisable with nearly powdery, when decoction in the step (2) is 5-6 hours a length of, and the relative density of paste is in the step (2)
1.04, be mixed in the step (2) when it is 5-10 minutes a length of, borneol and azone be before addition in the step (4)
It is both needed to carry out break process, pressure sensitive adhesive is made of hot melt pressure sensitive glue in the step (4).
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| Application Number | Priority Date | Filing Date | Title |
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| CN201910509120.7A CN110075190A (en) | 2019-06-13 | 2019-06-13 | The dedicated drug paste of dysmenorrhea |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1850159A (en) * | 2005-04-22 | 2006-10-25 | 北京荣昌药物研究院有限公司 | Navel plastering piece for treating dysmenorrhea and preparing method |
| CN109589362A (en) * | 2019-02-18 | 2019-04-09 | 陈金凤 | A kind of circulation navel paster and preparation method thereof for alleviating menalgia |
-
2019
- 2019-06-13 CN CN201910509120.7A patent/CN110075190A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1850159A (en) * | 2005-04-22 | 2006-10-25 | 北京荣昌药物研究院有限公司 | Navel plastering piece for treating dysmenorrhea and preparing method |
| CN109589362A (en) * | 2019-02-18 | 2019-04-09 | 陈金凤 | A kind of circulation navel paster and preparation method thereof for alleviating menalgia |
Non-Patent Citations (1)
| Title |
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| 李仲平等: "中药敷脐法治疗原发性痛经60例", 《陕西中医》 * |
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Application publication date: 20190802 |