CN109589362A - A kind of circulation navel paster and preparation method thereof for alleviating menalgia - Google Patents
A kind of circulation navel paster and preparation method thereof for alleviating menalgia Download PDFInfo
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- CN109589362A CN109589362A CN201910119270.7A CN201910119270A CN109589362A CN 109589362 A CN109589362 A CN 109589362A CN 201910119270 A CN201910119270 A CN 201910119270A CN 109589362 A CN109589362 A CN 109589362A
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Abstract
The present invention relates to Chinese medicinal recovery circulation navel paster more particularly to a kind of circulation navel pasters and preparation method thereof for alleviating menalgia.A kind of circulation navel paster for alleviating menalgia, rehabilitation circulation navel paster contains Chinese medicine material extract and substrate, and wherein Chinese medicine material extract is according to parts by weight are as follows: 10 ~ 40 parts of Radix Angelicae Sinensis, 10 ~ 40 parts of motherwort, 10 ~ 30 parts of rhizome of chuanxiong, 10 ~ 30 parts of Radix Paeoniae Alba, 10 ~ 30 parts of cortex cinnamomi, 10 ~ 20 parts of Rehmannia glutinosa, 5 ~ 15 parts of safflower, 5 ~ 15 parts of evodia rutaecarpa, 5 ~ 15 parts of rhizoma corydalis and 5 ~ 15 parts of mixing Chinese medicine materials of asarum are extracted and are concentrated and dried；Also, substrate is according to parts by weight are as follows: 1-5 parts of potassium sorbate, 10-40 parts of modified superfine far-infared ceramic powder, 10-30 parts of negative ion powder, 20-90 parts of aerosil particles；Rehabilitation circulation navel paster allows raw material to be sufficiently mixed dispersion, and various raw materials are combined by modified obtained ultra-fine far-infared ceramic powder, solves the technical issues of prior art dispersion is bad, fever is uneven, curative effect cannot give full play to.
Description
Technical field
The present invention relates to Chinese medicinal recovery circulation navel paster more particularly to it is a kind of alleviate menalgia circulation navel paster and its
Preparation method.
Background technique
There is lower abdomen spasmic pain during meaning menstrual period front and back or passing through in dysmenorrhea disease (dysmenorrhea), and
There is general malaise, seriously affects daily life person.It is divided to primary and two kinds secondary.Primary dysmenorrhea disease: the cause of disease is at present still
It is not fully apparent from.There is dysmenorrhea afterwards shortly after in first menses, sometimes closely related with mental element.It may also be due to uterus muscle convulsion
Contraction is shunk, and is led to uterus ischemic and is caused dysmenorrhea.It is more common in hypoplasia of uterus, cervix opening or canal of uterine cervix is narrow, uterus
Hyperflexion keeps menses outflow unsmooth, retention of menses is caused, so that uterine contraction be stimulated to cause dysmenorrhea.Some is interior in the menstrual period
Film falls off in the form of sheets, and preceding uterus strong contraction is discharged and causes pain, and symptom mitigates after discharge, claims membranous dysmenorrhoea.Primary dysmenorrhea
Multipotency is alleviated after fertility.
Chinese medicine thinks that it is mostly caused because QI-blood circulation is unsmooth.Qi being the governor of blood, the stagnation of the circulation of vital energy then blood stasis, spirit is unsmooth to cause irritability
Pent-up, liver-qi depression, disorder of qi prevent gas from transporting blood to pass unimpeded, and blood cannot circulate with gas, so that punching appoints passages through which vital energy circulates unfavorable,
Have a pain in born of the same parents through stasis.Treatment with activating microcirculation and removing stasis medicinal, it is warming channel and expelling cold based on.Chinese medicine generally uses Chinese medicine to adjust at present, but in
The oral inconvenience of medicine, patch mean Pasting on the skin, and drug can produce a kind of systemic or local action flake system
Agent.It is absorbed by skin, and dosage can be needed by the state of an illness by controlled release mechanism, quickly, persistently enter whole body.
Currently, the patch of domestic production is mainly patch, and it is mostly rubber ointment, the traditional matrices composition of raw materials used
In, natural rubber is widely used as framework material.Rubber ointment adhesion is strong, easy to use, passes through Transdermal absorption performance office
The effect of portion treatment and systemic therapy, drug effect are significant.But clinically there is also certain limitations in use process for rubber ointment
Property mainly to the irritation and allergic reaction of skin, symptom mainly has skin to itch, inflammation, plays pimple, long bubble, meeting when serious
Cause anaphylactic shock, to reduce the comfort of rubber ointment, safety and validity.
Summary of the invention
For this purpose, the first purpose of the invention is to provide a kind of circulation navel paster for alleviating menalgia, which is followed
Ring navel paster allows raw material to be sufficiently mixed dispersion by modified obtained ultra-fine far-infared ceramic powder, and by various raw materials
It combines, solves the technical issues of prior art dispersion is bad, fever is uneven, curative effect cannot give full play to.
A second object of the present invention is to provide a kind of preparation methods of circulation navel paster for alleviating menalgia.
In order to realize first above-mentioned purpose, present invention employs technical solutions below:
A kind of circulation navel paster for alleviating menalgia, rehabilitation circulation navel paster contain Chinese medicine material extract and substrate,
Middle Chinese medicine material extract is according to parts by weight are as follows:
10 ~ 40 parts of Radix Angelicae Sinensis, 10 ~ 40 parts of motherwort, 10 ~ 30 parts of rhizome of chuanxiong, 10 ~ 30 parts of Radix Paeoniae Alba, 10 ~ 30 parts of cortex cinnamomi, Rehmannia glutinosa 10 ~ 20
Part, 5 ~ 15 parts of safflower, 5 ~ 15 parts of evodia rutaecarpa, 5 ~ 15 parts of rhizoma corydalis and 5 ~ 15 parts of mixing Chinese medicine materials of asarum extract and be concentrated and
At；
Also, substrate is according to parts by weight are as follows: 1-5 parts of potassium sorbate, 10-40 parts of modified superfine far-infared ceramic powder, anion
10-30 parts of powder, 20-90 parts of aerosil particles；
The modified superfine far-infared ceramic powder, is that coupling agent is added into far-infared ceramic powder, is sufficiently stirred, filtration drying,
Then air-flow crushing obtains modified superfine far-infared ceramic powder.
As a further improvement, wherein Chinese medicine material extract is by according to parts by weight are as follows: 30 ~ 40 parts of evodia rutaecarpa, radix scutellariae
22 ~ 28 parts, 15 ~ 25 parts of Fructus Forsythiae, 15 ~ 25 parts of the coptis, 6 ~ 8 parts of arisaema cum bile, 6 ~ 8 parts of Radix picrorrhizae, 6 ~ 8 parts of asparagus fern mountain, Honeysuckle flower 6 ~ 8
Part, 3 ~ 6 parts of rheum officinale, 3 ~ 6 parts of radix scrophulariae and 3 ~ 6 parts of Radix Glycyrrhizae of mixing Chinese medicine material are extracted and are concentrated.
As a further improvement, wherein Chinese medicine material extract is by according to parts by weight are as follows: 30 parts of Radix Angelicae Sinensis, motherwort 30
Part, 20 parts of rhizome of chuanxiong, 20 parts of Radix Paeoniae Alba, 20 parts of cortex cinnamomi, 15 parts of Rehmannia glutinosa, 10 parts of safflower, 10 parts of evodia rutaecarpa, 10 parts of rhizoma corydalis and asarum
10 parts of mixing Chinese medicine material is extracted and is concentrated.
As a further improvement, the parts by weight of substrate are relative to Chinese medicine material, the parts by weight of substrate are relative to Chinese medicine
Raw material is potassium sorbate 3.2-3.8 parts, 25-35 parts of modified superfine far-infared ceramic powder, 15-25 parts of negative ion powder, aerosil particles
30-70 parts.
The present invention recycles the modified superfine far-infared ceramic powder in navel paster, is changed using coupling agent to far-infared ceramic powder
Property, coupling agent is added into far-infared ceramic powder, is sufficiently stirred, filtration drying, then air-flow crushing, finally obtains modified superfine
Far-infared ceramic powder, by changing the surface property of far-infared ceramic powder, allow itself and Chinese medicine material is fully dispersed mixes,
The combination between raw material is improved, has the function that the uniform raising medicament validity of heat generating spot.It is preferred that modified superfine is remote
The average grain diameter d of infrared ceramic powder50For 200-2000nm.
As a further improvement, the coupling agent is selected from silane coupling agent or titanate coupling agent.It is preferred that the idol
Joining agent is KH550, KH560, KH570 or KH792, and dosage is 0.1~5% parts by weight of far-infared ceramic powder, and preferable amount is remote
0.5~2% parts by weight of infrared ceramic powder.
As a further improvement, rehabilitation circulation navel paster further comprises 10-25 parts of aerosil, diatomite
5-20 parts and polyvinyl alcohol glue 5-20 parts.
As a further improvement, 15-24 parts of aerosil, 10-18 parts of diatomite and polyvinyl alcohol glue 10-15
Part.
Rehabilitation of the invention recycles navel paster, using following preparation method:
(1) Radix Angelicae Sinensis, motherwort, rhizome of chuanxiong, Radix Paeoniae Alba, cortex cinnamomi, Rehmannia glutinosa, safflower, evodia rutaecarpa, rhizoma corydalis and thin are weighed according to formula ratio
It is pungent, co-grinding is carried out using ultrafine crusher, is sieved with 100 mesh sieve；
(2) deionized water is added into obtained powder and carries out infiltration 30 minutes；
The mixture obtained at (3) 100 DEG C to step (2) carries out Chinese medicine liquid extraction, extracts 3 times repeatedly, merge concentration, obtains
Medicament extracting solution, for use；
(4) coupling agent is added into far-infared ceramic powder, is uniformly mixed, 250 DEG C are stirred 30 minutes, washing filtering, vacuum drying,
Using air-flow crushing, average grain diameter d is obtained50For the modified superfine far-infared ceramic powder of 200-2000nm；
(5) by the modified superfine far-infared ceramic powder, negative ion powder of (4) the step of the Chinese medicine extract and formula ratio of step (3),
Potassium sorbate is stirred stirring, is kept for 200 DEG C of temperature, mixing speed 200r/min is stirred 40 minutes；
(6) aerosil particles are measured according to composition of raw materials, the heating melting at 185-230 DEG C is added the mixture of step (5), adds
Enter vulcanizing agent injection mold, high temperature vulcanized demoulding obtains rehabilitation circulation navel paster, wherein high temperature vulcanized temperature is 150-180 DEG C.
Further, rehabilitation of the invention circulation navel paster also contains heat preservation temperature control layer, by including aerosil
10-25 parts, 5-20 parts of diatomite and 5-20 parts of polyvinyl alcohol glue；It is preferred that 15-24 parts of aerosil, diatomite 10-18
Part and polyvinyl alcohol glue 10-15 parts of mixture are prepared.
Slow down medicament using its structural void degree by addition aerosil and diatomite and directly act on skin
The side effect of skin reconciles Chinese drugs agentia to the burning sensation of skin, controls temperature, obtains the comfortable sense that sticks, and pass through energy storage function
Effect mitigates medicament drug effect, extends pharmacy effect.
In another embodiment, preparation method of the invention includes:
(1) according to formula ratio weigh Radix Angelicae Sinensis processed, motherwort, rhizome of chuanxiong, Radix Paeoniae Alba, cortex cinnamomi, Rehmannia glutinosa, safflower, evodia rutaecarpa, rhizoma corydalis and
Asarum carries out co-grinding using ultrafine crusher, sieves with 100 mesh sieve；
(2) deionized water is added in the powder obtained to step (1) and carries out infiltration 30 minutes；
The mixture obtained at (3) 100 DEG C to step (2) carries out Chinese medicine liquid extraction, extracts 3 times repeatedly, merge concentration, obtains
Medicament extracting solution, for use；
(4) coupling agent is added into far-infared ceramic powder, is uniformly mixed, 250 DEG C are stirred 30 minutes, washing filtering, vacuum drying,
Using air-flow crushing, average grain diameter d is obtained50For the modified superfine far-infared ceramic powder of 200-2000nm, for use；
(5) aerosil, diatomite and polyvinyl alcohol glue of formula ratio are taken, it is mixed with the speed of mixing speed 200r/min
Stirring 20 minutes is closed, mixture is obtained；
(6) by the Chinese medicine extract of step (3), step (5) mixture and formula ratio the step of (4) modified superfine far infrared
Ceramic powder, negative ion powder, potassium sorbate are stirred stirring, are kept for 200 DEG C of temperature, mixing speed 200r/min stirs 40 points
Clock；
(7) aerosil particles, the heating melting at 185-230 DEG C are measured according to composition of raw materials, the mixture that step (6) are added is added
Sulfide, injects mold, and high temperature vulcanized demoulding obtains rehabilitation circulation navel paster；Wherein high temperature vulcanized temperature is 180 DEG C.
Compared with prior art, the modified superfine far-infared ceramic powder that the present invention uses is made by specific method of modifying
It obtains far-infared ceramic powder and has excellent surface property, can have good dispersibility with other components, existing skill will not be generated
Circulation navel paster fever in art is uneven, the incomplete technical problem of drug action；In addition present invention adds silica
Aerosol and diatomite reach control temperature using its textural porosity, alleviate drug effect and continuingly act on burning for skin generation
Sense, and by energy storage effect extend drug effect play time, while in patient in use, can with appropriate adjustment use the time,
It can repeatedly be repeatedly circulated, it is flexible and convenient to use.
Circulation navel paster of the invention, which has close to the comfortable of body temperature, sticks impression, while guaranteeing that drug effect can sufficiently be sent out
It waves, there are the malaise symptoms for alleviating menalgia, promote health.Product of the present invention formula constitute it is fairly simple, product quality compared with
Easy to control, extracted its effective component that obtains of bulk pharmaceutical chemicals makes it be easier to absorb and play drug effect, preferably improves drug of the present invention
Therapeutic effect, thus provide it is a kind of can the grieved traditional Chinese medicine for outer use of significantly more efficient treatment.The system of Chinese materia medica preparation of the present invention
Preparation Method is simple, stable product quality, not ixoderm skin, be not required to heat, have no toxic side effect, nonirritant, non-sensitization, clinic can
It is used for a long time.
Specific embodiment
The present invention is further explained combined with specific embodiments below.
Embodiment 1
Rehabilitation of the invention recycles navel paster, according to weight fraction, formula are as follows: 300 grams of Radix Angelicae Sinensis, 300 grams of motherwort, rhizome of chuanxiong 200
Gram, 200 grams of Radix Paeoniae Alba, 200 grams of cortex cinnamomi, 150 grams of Rehmannia glutinosa, 100 grams of safflower, 100 grams of evodia rutaecarpa, 100 grams of rhizoma corydalis, asarum 100
Gram, 32 grams of potassium sorbate, 302 grams of modified superfine far-infared ceramic powder, 200 grams of negative ion powder, 600 grams of aerosil particles.Far infrared
300 grams of ceramic powder raw material, coupling agent used are KH792, and dosage is 2.0 grams, obtain 302 grams of far infrared ultrafine ceramic powder.Dioxy
180 grams of SiClx aeroge, 120 grams of diatomite and 100 grams of polyvinyl alcohol glue.
The preparation method is as follows:
(1) Radix Angelicae Sinensis, motherwort, rhizome of chuanxiong, Radix Paeoniae Alba, cortex cinnamomi, Rehmannia glutinosa, safflower, evodia rutaecarpa, rhizoma corydalis and thin are weighed according to formula ratio
It is pungent, co-grinding is carried out using ultrafine crusher, is sieved with 100 mesh sieve；
(2) 1200ml deionized water is added in the powder obtained to step (1) and carries out infiltration 30 minutes；
Chinese medicine liquid extraction is carried out to mixture to step (2) at (3) 100 DEG C, is mentioned using conventional medium-sized traditional Chinese medicine extraction system
It takes, extracts 3 times repeatedly, further merge concentration, obtain mixture a, for use；
(4) far-infared ceramic powder is taken, coupling agent KH560 is added thereto, is uniformly mixed, stirs 30 in reaction pot at 250 DEG C
Minute, it takes out, is dried under vacuum 150 minutes after washing filtering with vacuum oven, it is cooling after taking-up, it is placed in commercially available air-flow powder
Air-flow crushing is carried out in broken machine, obtains average grain diameter d50For the modified superfine far-infared ceramic powder of 200-2000nm；
(5) take the traditional Chinese medicine extraction of step (3) be concentrated the modified superfine far-infared ceramic powder of rough material and step (4), negative ion powder,
Potassium sorbate is stirred stirring, is kept for 200 DEG C of temperature, and mixing speed 200r/min is stirred 40 minutes, obtains mixture c；
(6) aerosil, diatomite and polyvinyl alcohol glue of formula ratio are taken, it is mixed with the speed of mixing speed 200r/min
Stirring 20 minutes is closed, mixture b is obtained；
(7) mixture c obtained in mixture a obtained in step (3) and step (5) is mixed, with mixing speed 250r/
Min is stirred 30 minutes；
(8) painting of mixture obtained in step (7) is pressed on aerosil particles substrate；
(9) mixture b painting will be obtained in step (6) to be pressed on the substrate that step (8) obtains, and obtains external application physical therapy plaster.
(10) about 3-15 rehabilitations circulation navel pasters can be made according to mold size and actual use dimensional thickness, preferably 2
?.
Comparative example 1
Formula and the embodiment 1 for recycling navel paster are identical, and it is remote to replace modified superfine therein with common commercially available far-infared ceramic powder
Infrared ceramic powder, the preparation method is the same as that of Example 1.
Comparative example 2
Recycle the formula of navel paster are as follows: 300 grams of Radix Angelicae Sinensis, 300 grams of motherwort, 200 grams of rhizome of chuanxiong, 200 grams of Radix Paeoniae Alba, 200 grams of cortex cinnamomi, ripe
150 grams of glutinous rehmannia, 100 grams of safflower, 100 grams of evodia rutaecarpa, 100 grams of rhizoma corydalis and 100 grams of asarum.Conventional method prepares rubber ointment.
Comparative example 3
Choose commercially available far infrared circulation navel paster.
Test example 1
Detect the recurrent aphthous ulcer temperature and efficacy time of each embodiment and comparative example.
Temperature and efficacy time evaluation and test are sticked, the results are shown in Table 1:
Table 1 sticks temperature and efficacy time evaluation and test
| Comparison project | Stick temperature (DEG C) | Efficacy time (hour) |
| Embodiment 1 | 36-40 | 18-24 |
| Comparative example 1 | 40-45 | 12-16 |
| Comparative example 2 | 35-38 | 10-12 |
| Comparative example 3 | 45-50 | 10-12 |
The experimental results showed that, rehabilitation circulation navel paster of the present invention, which obviously has, comfortably sticks temperature above, not will cause skin
Burn feeling and adverse reaction, and keep lasting efficacy time simultaneously.
Test example 2
1.1 general information
Research is double blind random cross over study, observes 8 menstrual cycles of each subject.It is collected in the 1st menstrual cycle
The information of subject is to do baseline assessments.First stage treatment includes 2 menstrual cycles.Followed by 3 menstrual cycles it is clear
It washes the stage, second stage treatment equally includes 2 menstrual cycles.60 qualified research objects are divided into using random double-blind method
Test group and control group, every group each 30.The standard of being included in of research object includes: 1. age 17~22 years old；2. unmarried；3. menstruation
Periodic law (21-35 d)；4. menstrual period are in 3.7 d；5. continuously 6 months experts are premenstrual in the past without general disease or gynecological disease
Lower abdominal pain afterwards or when menstrual onset, the duration in 30 min or more, and without the inducement that obviously pain can be made to slow down.
Intervention trial is carried out after random grouping, test group and control group, which are given, takes Fenbid spansule (300 mg)
Primary Care, when menstrual onset abdominal pain take orally, monthly 1 time, through come when stop.Test group gives embodiment 1 institute simultaneously
The rehabilitation circulation navel paster treatment stated.Choose Guanyuan point, SHENQUE acupoint in acupuncture point.5~7 d start to treat before menstrual onset, and daily 2
It is secondary, be recycled, 6~8 h every time, through to when stop treating.During treatment, dysmenorrhea information and index of correlation are acquired.2 months
After the period, stop intervening.After being spaced 3 menstrual cycles, the intervening measure of test group and control group is exchanged.2 groups of completion examinations
Situation is tested, test group completes 27, falls off 3；Control group completes 29, falls off 1.
1.2 appraisal tool
With visual analogue scale table (VAS), verbal rating scale (VRS), digital evaluation charter (NRS), behavior pain determining table
(BRS-6), pain rating index scale (PRI) and retrospective Syndrome Scale (retrospeetive symptom scale,
RSS it) scores.Above-mentioned evaluation index { is handed in the 1st menstrual cycle (baseline), the 2nd menstrual cycle and the 3rd menstrual cycle
First treatment cycle and the second treatment cycle of (first stage treatment) before fork treatment } and the 7th menstrual cycle and the 8th
The third treatment cycle and the 4th treatment cycle 1 of (second stage treatment) measure after menstrual cycle, that is, cross-fire treatment.
1.3 statistical method
Data statistics is completed using 17.0 statistical software of SPSS.Measurement data is indicated with mean ± standard deviation (x ± S), between two groups
Compare using independent samples t test, compares with itself front and back between group using paired t-test.Ranked data are indicated with number of cases, between group
Compare using rank sum test.It is that difference is statistically significant with P < 0.05.
1.4 result
2 groups of Baseline Data comparison sheets 2 are as the result is shown: 2 groups of age, dysmenorrhea history, menstrual cycle, age of menarche, menstruation continue day
Relatively (independent samples t test), difference is not statistically significant (P > 0.05), is comparable for number.
The test of table 2 intervenes preceding 2 groups of Baseline Datas and compares (1)
Table 3~4 is as the result is shown: before test, 2 groups of PRI scoring (feeling item, emotion item, total score) is scored with VAS, and BRS-6 is commented
Point, RSS scores (severity total score, RSS sum frequency total score), NRS scoring, and VRS scoring, which is compared, (independent samples t test and to be waited
Grade data rank sum test), difference is not statistically significant (P > 0.05), is comparable.
The test of table 3 intervenes preceding 2 groups of Baseline Datas and compares (2)
The test of table 4 intervenes preceding 2 groups of Baseline Datas and compares (3)
Comparison sheet before cross-fire treatment between 2 groups of (first stage treatment)
Table 5 is as the result is shown: after the treatment of prechiasmal first treatment cycle, 2 groups of VAS, BRS-6, PRI scoring is compared, difference
Not statistically significant (P > 0.05)；After the treatment of the second treatment cycle, VAS, BRS-6, PRI scoring of test group are significant low
In control group, difference is statistically significant (P < 0.05 or P < 0.01).
The fork of table 5 is treated preceding 2 groups VAS, BRS-6, PRI scoring and is compared
Table 6-7 is as the result is shown: after being intersected preceding first treatment cycle and the treatment of the second treatment cycle, the NRS and VRS of test group are commented
Curative effect is divided to be better than control group, difference is statistically significant (P < 0.01).
The fork of table 6 is treated preceding 2 groups of NRS scoring and is compared
The fork of table 7 is treated preceding 2 groups of VRS scoring and is compared
Comparison sheet 8 after cross-fire treatment between 2 groups of (second stage treatment) is as the result is shown: the third treatment cycle treatment after intersecting
Afterwards, 2 groups of VAS, BRS-6, PRI scoring is compared, and difference is not statistically significant (P > 0.05)；It is treated through the 4th treatment cycle
Afterwards, VAS, BRS-6, PRI scoring of control group is substantially less than test group, difference it is statistically significant (P < O.05 or P <
0.01).
2 groups of VAS, BRS-6, PRI scoring is compared after the fork treatment of table 8
Table 9-10 is as the result is shown: after the third treatment cycle and the treatment of the 4th treatment cycle after intersecting, the NRS of control group and
VRS scoring curative effect is superior to test group, and difference is statistically significant (P < 0.01).
2 groups of VRS scoring is compared after the fork treatment of table 9
2 groups of VRS scoring is compared after the fork treatment of table 10
The display of this result of study: after 2 menstrual cycle treatments of first stage, test group is to VAS, BRS-6, PRI, NRS, VRS
The improvement result of scale score is superior to control group, and difference is statistically significant (P < 0.05 or P < 0.01)；Through second stage 2
After a menstrual cycle treatment, control group is superior to test group to the improvement result of VAS, BRS-6, PRI, NRS, VRS scale score,
Difference is statistically significant (P < 0.05 or P < 0.01).Show that acupoint application of Chinese herb can effectively alleviate the menstrual period of Female student
Pain and dysmenorrhea symptom.
Rehabilitation of the present invention circulation navel paster because with high security, side effect it is less (in addition to skin sensitive subjects), can be by disease
Position medication guides drugs to illness station drug effect, easy to operate, easy to spread, curative for effect, no to dig the advantages that painless, can be widely applied for
The disadvantages of clinic is closed, and the adverse drug reaction and long-term efficacy relative to western medicine primary dysmenorrhea are dissatisfied, was worth in day
Often widelyd popularize in life.
Claims (10)
1. a kind of circulation navel paster for alleviating menalgia, the circulation navel paster contain Chinese medicine material extract and substrate, wherein
Chinese medicine material extract is according to parts by weight are as follows:
10 ~ 40 parts of Radix Angelicae Sinensis, 10 ~ 40 parts of motherwort, 10 ~ 30 parts of rhizome of chuanxiong, 10 ~ 30 parts of Radix Paeoniae Alba, 10 ~ 30 parts of cortex cinnamomi, Rehmannia glutinosa 10 ~ 20
Part, 5 ~ 15 parts of safflower, 5 ~ 15 parts of evodia rutaecarpa, 5 ~ 15 parts of rhizoma corydalis and 5 ~ 15 parts of mixing Chinese medicine materials of asarum extract and be concentrated and
At；
Also, substrate is according to parts by weight are as follows: 1-5 parts of potassium sorbate, 10-40 parts of modified superfine far-infared ceramic powder, anion
10-30 parts of powder, 20-90 parts of aerosil particles；
The modified superfine far-infared ceramic powder, is that coupling agent is added into far-infared ceramic powder, is sufficiently stirred, filtration drying,
Then air-flow crushing obtains modified superfine far-infared ceramic powder.
2. it is according to claim 1 it is a kind of alleviate menalgia circulation navel paster, which is characterized in that Chinese medicine material extract by
According to parts by weight are as follows: 20 ~ 30 parts of Radix Angelicae Sinensis, 20 ~ 30 parts of motherwort, 15 ~ 25 parts of rhizome of chuanxiong, 15 ~ 25 parts of Radix Paeoniae Alba, 15 ~ 25 parts of cortex cinnamomi,
12 ~ 18 parts of Rehmannia glutinosa, 8 ~ 12 parts of safflower, 8 ~ 12 parts of evodia rutaecarpa, 8 ~ 12 parts of rhizoma corydalis and 8 ~ 12 parts of asarum of mixing Chinese medicine material
It extracts and is concentrated.
3. a kind of circulation navel paster for alleviating menalgia according to claim 1, which is characterized in that the parts by weight phase of substrate
For Chinese medicine material, be potassium sorbate 3.2-3.8 parts, 25-35 parts of modified superfine far-infared ceramic powder, 15-25 parts of negative ion powder,
30-70 parts of aerosil particles.
4. a kind of circulation navel paster for alleviating menalgia according to claim 1, which is characterized in that the modification is super
The average grain diameter d of thin far-infared ceramic powder50For 200-2000nm.
5. a kind of circulation navel paster for alleviating menalgia according to claim 1, which is characterized in that the coupling agent
Selected from silane coupling agent or titanate coupling agent.
6. a kind of circulation navel paster for alleviating menalgia according to claim 5, which is characterized in that the coupling agent is
KH550, KH560, KH570 or KH792, dosage are 0.1~5% parts by weight of far-infared ceramic powder.
7. a kind of circulation navel paster for alleviating menalgia according to claim 6, which is characterized in that dosage is far infrared
0.5~2% parts by weight of ceramic powder.
8. a kind of circulation navel paster for alleviating menalgia according to claim 1 or 2, which is characterized in that the circulation tripe
Navel patch further comprises 10-25 parts of aerosil, 5-20 parts of diatomite and 5-20 parts of polyvinyl alcohol glue.
9. a kind of circulation navel paster for alleviating menalgia according to claim 8, which is characterized in that silica airsetting
15-24 parts of glue, 10-18 parts of diatomite and 10-15 parts of polyvinyl alcohol glue.
10. a kind of preparation method for the circulation navel paster for alleviating menalgia, which is characterized in that -7 is any according to claim 1
The formula of the circulation navel paster of item, prepares according to following preparation method:
(1) Radix Angelicae Sinensis, motherwort, rhizome of chuanxiong, Radix Paeoniae Alba, cortex cinnamomi, Rehmannia glutinosa, safflower, evodia rutaecarpa, rhizoma corydalis and thin are weighed according to formula ratio
It is pungent, co-grinding is carried out using ultrafine crusher, is sieved with 100 mesh sieve；
(2) deionized water is added into obtained powder and carries out infiltration 30 minutes；
Chinese medicine liquid extraction is carried out to the mixture that step (2) obtains at (3) 100 DEG C, extracts 3 times repeatedly, obtains Chinese medicine extract,
Concentration, for use；
(4) coupling agent is added into far-infared ceramic powder, is uniformly mixed, 250 DEG C are stirred 30 minutes, washing filtering, vacuum drying,
Using air-flow crushing, average grain diameter d is obtained50For the modified superfine far-infared ceramic powder of 200-2000nm；
(5) by the modified superfine far-infared ceramic powder, negative ion powder of (4) the step of the Chinese medicine extract and formula ratio of step (3),
Potassium sorbate is stirred stirring, is kept for 200 DEG C of temperature, mixing speed 200r/min is stirred 40 minutes；
(6) aerosil particles are measured according to composition of raw materials, the heating melting at 185-230 DEG C is added the mixture of step (5), adds
Enter vulcanizing agent injection mold, high temperature vulcanized demoulding obtains circulation navel paster, wherein high temperature vulcanized temperature is 150-180 DEG C.
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| CN201910283497.5A CN110025692A (en) | 2019-02-18 | 2019-04-10 | A kind of circulation navel paster and preparation method thereof for alleviating menalgia |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110075190A (en) * | 2019-06-13 | 2019-08-02 | 吕利民 | The dedicated drug paste of dysmenorrhea |
| CN110339332A (en) * | 2019-08-19 | 2019-10-18 | 北京郭氏益德堂中医药科技院 | A kind of Chinese medicine composition and preparation method thereof for treating gynaecological disease |
| CN111109690A (en) * | 2020-01-07 | 2020-05-08 | 承德佐合堂生物科技有限公司 | Underpants for hot compress of Shenque acupoint |
| CN112690949A (en) * | 2020-12-21 | 2021-04-23 | 福建恒安集团有限公司 | Preparation method of pants-type sanitary towel with temperature-sensing and heating functions |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1199658C (en) * | 2000-10-18 | 2005-05-04 | 沈阳东宇企业集团有限公司研究院 | Chinese medicine navel melted tablet for treating menalgia and its prepn |
| CN102836249B (en) * | 2012-09-19 | 2014-07-02 | 王富春 | Drugs for treating dysmenorrheal |
| CN105943238A (en) * | 2016-06-15 | 2016-09-21 | 马南行 | Hot compress sticker for improving microcirculation and preparation method thereof |
| CN108478932A (en) * | 2018-03-29 | 2018-09-04 | 缔道（天津）生物科技有限责任公司 | Multifunction infrared mild moxibustion physiotherapy note product and preparation method thereof |
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2019
- 2019-02-18 CN CN201910119270.7A patent/CN109589362A/en not_active Withdrawn
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110075190A (en) * | 2019-06-13 | 2019-08-02 | 吕利民 | The dedicated drug paste of dysmenorrhea |
| CN110339332A (en) * | 2019-08-19 | 2019-10-18 | 北京郭氏益德堂中医药科技院 | A kind of Chinese medicine composition and preparation method thereof for treating gynaecological disease |
| CN111109690A (en) * | 2020-01-07 | 2020-05-08 | 承德佐合堂生物科技有限公司 | Underpants for hot compress of Shenque acupoint |
| CN112690949A (en) * | 2020-12-21 | 2021-04-23 | 福建恒安集团有限公司 | Preparation method of pants-type sanitary towel with temperature-sensing and heating functions |
| CN112690949B (en) * | 2020-12-21 | 2022-08-05 | 福建恒安集团有限公司 | Preparation method of pants-type sanitary towel with temperature-sensing and heating functions |
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Application publication date: 20190409 |