CN110063976A - It is a kind of for preventing the spray and preparation method thereof of newborn piglet asphyxia - Google Patents
It is a kind of for preventing the spray and preparation method thereof of newborn piglet asphyxia Download PDFInfo
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- CN110063976A CN110063976A CN201910371373.2A CN201910371373A CN110063976A CN 110063976 A CN110063976 A CN 110063976A CN 201910371373 A CN201910371373 A CN 201910371373A CN 110063976 A CN110063976 A CN 110063976A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7024—Esters of saccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
Abstract
It is a kind of for preventing the spray and preparation method thereof of newborn piglet asphyxia, the weight of every 100g spray forms are as follows: 0.01~0.5g of benzalkonium bromide, 0.05~2.0g of tannic acid, 0.01~3.0g of mustard oil, 2.0~6.0g of PLURONICS F87,10.0~20.0g of emulsifier TX-100,5.0~10.0g of isopropanol, surplus is deionized water.Spray of the invention has significant anti-suffocation effect to newborn piglet.In use, the nostril and oral cavity to newborn piglet are sprayed, it can make it that remaining amniotic fluid and mucus in tracheae, nasal meatus and oral cavity quickly be discharged, prevent from causing to suffocate because of blocking, also there is prevention effect to the cause of disease infected through respiratory tract approach.The present invention further discloses preparation method, and process operability is strong, at low cost, is conducive to production conversion, wide market.
Description
Technical field
The invention belongs to veterinary medicine technical fields, and in particular to it is a kind of for prevent newborn piglet asphyxia spray and its
Preparation method.
Background technique
Newborn piglet asphyxia is phenomenon common in pig production, after being mostly born by piglet, in tracheae, nostril or oral cavity
Amniotic fluid and mucus cannot be discharged in time, block respiratory tract, outside air cannot be introduced into lung, and umbilical cord has been broken at this time, blood
Liquid can not obtain enough oxygen, ultimately cause piglet and be choked to death.Clinically common antasphyctic method be to piglet into
Row artificial respiration, specific method are that right-hand man holds the neck and buttocks of piglet respectively, along the big curved direction of abdomen, constantly
It bends and stretches, makes the passive expansion and contraction of lung by extraneous strength, force the tamper in tracheae, nasal meatus and oral cavity to be discharged, to make
Air can smoothly enter into lung, solve the problems, such as asphyxia.
Practice have shown that artificial respiration method is time-consuming and laborious, operation needs certain skill, if misoperation is also possible to meeting
Amniotic fluid or mucus suck-back are entered into lung, cause respiratory tract infection, meanwhile, artificial respiration method cannot be completely secured piglet and can deposit
Living, clinically saving success rate to reach 70% has been relatively high level.For large―scale hoggery, sow is substantially all
It is estrus synchronization, the same period breeds, and delivery time is also all concentrated in the same period.The childbirth phase has the piglet for much facing asphyxia,
Manpower often relative deficiency at this time, and consuming time is long for artificial respiration, it is dead because of anoxic finally always to have a part newborn piglet, gives
Bring certain economic loss in pig farm.
Currently, temporarily occurring not yet specifically for the product of prevention newborn piglet asphyxia on the market.In order to fill up
The market vacancy, the present invention are prepared for a kind of for preventing the spray of newborn piglet asphyxia, it is only necessary in piglet birth, to its nose
Hole and oral cavity position are spraying, and under the stimulation of medical fluid, piglet shows the sneezing and cough of initiative, in the impact of high-speed flow
Under, remaining amniotic fluid and mucus are quickly discharged in tracheae, nostril and oral cavity, so that air can be breathed in time by reaching, prevent from suffocating
Purpose.
Other than anti-suffocation function, it is temporary that spray of the invention can also be such that a variety of receptor proteins of nasal mucosal surface occur
Conformational change, prevent its from by the external world cause a disease original identify, the cause of disease in environment after nostril is invaded, can not specificity tie
It closes, to will not infect, certain prevention effect is played to the disease propagated by respiratory tract approach indirectly.
Summary of the invention
The purpose of the present invention is to provide a kind of for preventing the spray of newborn piglet asphyxia, while providing preparation method
It is another object of the present invention.
Based on above-mentioned purpose, the present invention is adopted the following technical scheme that: it is a kind of for prevent newborn piglet asphyxia spray and
Preparation method, the weight composition of every 100g spray are as follows: 0.01~0.5g of benzalkonium bromide, 0.05~2.0g of tannic acid, mustard oil
0.01~3.0g, 2.0~6.0g of PLURONICS F87,10.0~20.0g of emulsifier TX-100, isopropanol 5.0~10.0g, it is remaining
Amount is deionized water.
Preferably, the weight group of every 100g spray becomes, 0.1~0.3g of benzalkonium bromide, 0.5~1.5g of tannic acid, mustard oil
0.1~2.0g, 3.0~5.0g of PLURONICS F87,12.0~18.0g of emulsifier TX-100,7.0~9.0g of isopropanol, surplus
For deionized water.
It is further preferred that the weight group of every 100g spray becomes, benzalkonium bromide 0.2g, tannic acid 1.0g, mustard oil 1.0g,
PLURONICS F87 4.0g, emulsifier TX-100 15.0g, isopropanol 8.0g, deionized water 70.8g.
The deionized water is sterile deionized water.
Spray of the invention, appearance are the uniform faint yellow opaque emulsion of quality.
Described is a kind of for preventing the preparation method of the spray of newborn piglet asphyxia, comprising the following steps: (a) Jiang Boluo
Husky nurse 188 is added in emulsifier TX-100, is stirred continuously until PLURONICS F87 is completely dissolved, addition isopropanol, stirring is
It is even, obtain system A；(b) mustard oil is added in system A, is stirred evenly, obtain system B；(c) tannic acid and benzalkonium bromide are mixed
Afterwards, the deionized water of surplus is added, makes it completely dissolved, obtains system C；(d) system C is added gradually in system B, side edged
Mixed system is emulsified with mulser, system can gradually be become cloudy by clarifying, ultimately form quality it is uniform it is faint yellow not
Transparency emulsion, sealing packing to get.
Usage and dosage: being directed at the nostril and oral cavity position of newborn piglet, 1~3 time spraying.
Reasonable recipe of the present invention, to newborn piglet using safe, clinical use definite effect can significantly reduce piglet because stopping up
It is dead caused by breath, while there is significant prevention effect to the cause of disease infected through respiratory tract approach.
In prescription of the present invention, each component is in the effect wherein played are as follows:
1) benzalkonium bromide selected, is a kind of cationic surfactant, can change bacterial cytoplasm membrane permeability, make thallus
Endochylema extravasation hinders it to be metabolized and play killing effect.After nasal spray, bacterial pathogen can be prevented through respiratory tract
Infection purifies nasal cavity.
2) tannic acid selected can be deposited on nasal mucosal surface after spraying, play a certain protective role to schneiderian membrane, together
When, tannic acid can make it temporary conformational change occur, including but not limited to through breathing with the protein binding on mucomembranous cell surface
The specific binding receptor protein of the cause of disease of road approach infection.After variation occurs in receptor protein space conformation, cause of disease can not be to it
Normal identification, cannot also specifically bind, piglet would not infect, to play a certain protective role.
3) mustard oil selected is yellow mustard seed by light red oil liquid obtained by high temperature distillation, has peppery taste of choking
There is certain irritation in road to respiratory mucosa and oral mucosa, but irritation be it is temporary, several tens of seconds is only lasted for after contact,
Have the function of promoting its active sneezing and cough to piglet.When sneezing and cough the high-speed flow that is formed can by tracheae,
Remaining amniotic fluid and mucus discharge, make smooth breathing in oral cavity and nasal meatus, to prevent the generation of asphyxia.
4) PLURONICS F87 and emulsifier TX-100 selected, both emulsifier, the hydrophilic and oleophilic obtained after compounding
Equilibrium valve with by mustard oil emulsify required for hydrophilic lipophilic balance it is identical or close, the two cooperation can form stable mustard seed
Fat liquor.Meanwhile the two is mild to the property of tracheae, oral cavity and schneiderian membrane, has buffer function to the pungent road of choking of mustard oil, keeps away
Exempt from it and generate overstimulation, use is safe.
5) isopropanol selected, on the one hand can play and help emulsification, and on the other hand, isopropanol is to benzalkonium bromide, tan
Acid and mustard oil have certain solubilization, the unstable situation such as avoid occurring during drug post storage being precipitated.In addition, different
Propyl alcohol can be such that system liquidity enhances, and be conducive to spraying use.
Other than prescription advantage, simple process of the invention, strong operability, without introducing high-end and expensive equipment
It can produce, manufacturing cost is low, is conducive to a wide range of popularization in pig raising field, and market prospects are more wide.
The present invention is compared with the artificial respiration method of existing prevention piglet asphyxia, the effect that reaches are as follows:
1) spray of the invention can significantly stimulate newborn piglet that sneezing and cough behavior actively occurs, quick by air-flow
The amniotic fluid and mucus that block in tracheae, oral cavity and nasal meatus are discharged.It is easy to operate, it is time saving and energy saving, even if not practicing midwifery experience
New employee can also learn easily, and the piglet for saving an asphyxia only needs several seconds, and traditional artificial breath method may
Need several minutes of even dozens of minutes.
2) spray effect of the invention is more definite, and clinic proves that effective percentage can reach 90% or more, and conventional method is faced
For the effective percentage of bed statistics substantially between 30%~70%, the experienced person of practicing midwifery is efficient high, and practices midwifery for inexperienced
Member, most of newborn piglets are finally come to an end with death.
3) after spray of the invention is spraying, the protein receptor space conformation of Nasal Epithelial Cells can occur reversible temporary
When sexually revise, prevent it from being identified by the cause of disease in environment, to reduce the incidence of disease infected through respiratory tract approach,
The infection of the pathogenic original of such as Pseudorabies virus, respiratory and enteric coronavirus, Actinobacillus pleuropneumoniae.
4) after use of the present invention, it is net that antimicrobial component therein can carry out early stage to the bacterial pathogen in respiratory tract and oral cavity
Change, so as to reduce the disease incidence of bacteriosis, conducive to the growth in piglet later period.
5) preparation process strong operability of the invention is conducive to conversion, and the drug of preparation is at low cost, farm's acceptance
Height, it is clinical easily to promote.
Specific embodiment
The present invention will be illustrated by embodiment below, but these specific embodiments do not limit this hair in any way
Bright protection scope.
Embodiment 1-11
To keep specification more succinct, one kind described in embodiment 1-11 is provided in the form of a table below for preventing new life
The weight composition of the spray of piglet asphyxia, the total weight of each embodiment is 100g, and specific prescription is shown in Table 1.
Table 1 is a kind of for preventing the weight composition of the spray of newborn piglet asphyxia
It is described in embodiment 1 a kind of for preventing the preparation method of the spray of newborn piglet asphyxia, comprising the following steps:
(a) 4.00g PLURONICS F87 is added in 15.0g emulsifier TX-100, is stirred continuously until poloxamer
188 are completely dissolved, and 8.0g isopropanol is added, stirs evenly, obtains system A；
(b) 1.0g mustard oil is added in system A, is stirred evenly, obtain system B；
(c) after mixing 1.0g tannic acid and 0.2g benzalkonium bromide, 70.8g deionized water is added, stirring is completely dissolved, proper
It is C；
(d) system C is added gradually in system B, side edged emulsifies mixed system with mulser, and system is by clear
It gradually becomes cloudy clearly, ultimately forms the uniform faint yellow opaque emulsion of quality, sealing packing is to get spray of the invention.
The concrete operation step of embodiment 2-11 is the same as embodiment 1.
The property stability test of 12 product of the present invention of test example
The embodiment of the present invention 1-11 is sampled, carrying out room temperature respectively to each embodiment, (ambient temperature exists
15~25 DEG C), (40 DEG C of temperature, relative humidity 75%) accelerates to place, 4 DEG C of low temperature are placed and -20 DEG C cold under the conditions of high temperature and humidity
Freeze and places.When 0d, 15d, 30d, 90d, 180d and 360d after test, the aesthetic appearance of separately sampled each embodiment of observation
Shape, as a result, it has been found that room temperature, the sample for accelerating placement and low temperature to place, are precipitated situations such as precipitating without layering, discoloration, drug
Occur, the sample for freezing placement will appear icing, but after fusing of rising again again, and precipitating etc. also is precipitated now without layering, discoloration, drug
As property is stablized.
Conclusion (of pressure testing): product of the invention has preferable stability.
13 safety testing of test example
Safety of the present invention to newborn piglet is verified below by way of clinical test.
16 healthy newborn piglets are chosen, are randomly divided into 1,2,3 and 4 group, every group 4, male and female is fifty-fifty.Wherein the 1st group
For control group, any drug is not used, the 2nd, 3 and 4 group is test group, spraying to oral cavity and nostril position at the first time after birth
Medical fluid of the invention.The medical fluid of 1 invention of embodiment is fitted into spray bottle, the 2nd group of test piglet is respectively in its oral cavity and nostril portion
Each spray in position 1 time, same to operate, the 3rd group and the 4th group of piglet every each spray 5 times and 10 times respectively, with contrast verification drug
Safety.All piglets are raised in same environment, are raised using identical management mode.Test pig is respectively at medication
Rear 1h, 2h, 3h, 5h, 10h, for 24 hours, the inflammatory reaction and damage situations of 48h and 72h observation schneiderian membrane and mucous membrane of mouth, if
Performance indifference is compared with the 1st group of control group, then is represented well, with " √ " identification record.Each group test is observed during test again
The behavioral activity situation and death condition of pig, conscientiously make a record, the results are shown in Table 2.
The spray clinical safety test of the prevention newborn piglet asphyxia of the invention of table 2
| Number | 1h | 2h | 3h | 5h | 10h | 24h | 48h | 72h |
| 1st group | √ | √ | √ | √ | √ | √ | √ | √ |
| 2nd group | √ | √ | √ | √ | √ | √ | √ | √ |
| 3rd group | √ | √ | √ | √ | √ | √ | √ | √ |
| 4th group | √ | √ | √ | √ | √ | √ | √ | √ |
Note: (" √ " represents schneiderian membrane and mucous membrane of mouth is good, without impaired)
Test result:
1) the impaired aspect of mucous membrane: the 2nd, 1h, 2h of 3 and 4 groups of the test pig mucous membrane after medication, 3h, 5h, 10h, for 24 hours,
48h and 72h does not occur the 1st group of indifference of the inflammatory pathologies of red, swollen, hot, pain and dysfunction and control group；
2) each group test pig does not occur death, and behavior expression is normal and the 1st group of no significant difference of control group；
3) each group test pig is without other clinical manifestations of being poisoned；
Conclusion (of pressure testing): spray of the invention uses newborn piglet safe.
14 Pseudorabies virus of test example infects blocking test
Pseudoabies is a kind of Acute exposure sexually transmitted disease of pig, infected as Pseudorabies virus caused by, main infringement is young
The nervous system of pig, reproductive system can be largely influenced after sow infection, causes breeding difficulty.This disease is mainly passed through respiratory tract
It broadcasts, nostril is the important portal of virus infection, after poisoning intrusion schneiderian membrane, combined first with the protein receptor of mucomembranous surface,
Submucosa is further invaded later, forms viremia virusemia, and then is caused general infection and fallen ill.Spray of the invention makes
With rear, the Pseudorabies virus receptor protein of piglet nasal mucosal surface can be made temporary conformational change, nothing after poisoning intrusion occur
Protein receptor after method identification denaturation, and then infection cannot be formed, to play a protective role.
Newborn piglet 20 are randomly selected, is randomly divided into two groups, every group 10, male and female is fifty-fifty.First group is positive control
Group forces collunarium with the cell culture fluid containing Pseudorabies virus, makes its infection.Second group is test group, with spray of the invention
It is first directed at nasal spray, wait 2h and then forces collunarium with the cell culture fluid containing Pseudorabies virus, observes infection conditions.
All test pigs are raised in same environment, are raised using identical management mode.After Pseudorabies virus infection,
Incubation period is usually 3~5d, starts to show symptom later.For the accuracy of test data, this test period is set as one week,
Period observes the clinical manifestation and death condition of pig daily, counts morbidity and mortality.After the test, the blood of pig is extracted
The PCR molecular biology identification for carrying out virus, if there is infection, the result of nucleic acid amplification is the positive, conversely, result is feminine gender,
It is made a record during test.It the results are shown in Table 3.
The spray of the prevention newborn piglet asphyxia of the invention of table 3 infects blocking test to Pseudorabies virus
| Morbid pig number/only | Disease incidence/% | Dead pig number/only | The death rate/% | |
| 1st group | 9 | 90 | 7 | 70 |
| 2nd group | 2 | 20 | 1 | 10 |
After the test, the blood disease testing result of all pigs are as follows:
9 testing results of first group of morbidity are all positive, show to infect, and 1 not fallen ill result is feminine gender, do not feel
Dye；
2 testing results of second group of morbidity are the positive, show to infect, and 8 not fallen ill result is feminine gender, are uninfected by；
Pass through the comparison of test group and control group, the results showed that, spray of the invention is to the pseudoabies invaded through nostril
Malicious infection rate can reduce by 70%, and the death rate can reduce by 60%.
Conclusion (of pressure testing): a kind of spray for preventing newborn piglet asphyxia of the invention has pseudoabies good pre-
Anti- effect.
15 pharmacodynamic test of embodiment
The present invention is mainly oral cavity and the nostril nerve cell for relying on moment stimulation piglet, and newborn piglet is promoted actively to play spray
It sneezes and coughs, in the case where air-flow quickly flows, amniotic fluid remaining in tracheae, oral cavity and nasal meatus and mucus are gone out, to quickly make
Its breathing is unimpeded, prevents from suffocating.
Brood experiment pig 8 is randomly selected, is divided into two groups, every group 4, male and female is fifty-fifty.1st group be test group, four
Pig is respectively labeled as 1-1,1-2,1-3 and 1-4, the spray that after piglet birth prepared by the spraying embodiment of the present invention 1, nostril and oral cavity
It is each primary, piglet sneezing and cough behavior are observed later, with every 20s for a minor tick, records number, and the record time is
140s.2nd group is control group, and four pigs are respectively labeled as 2-1,2-2,2-3 and 2-4, in order to reduce the physics because generating by spraying
Sexual stimulus and stress are influenced caused by test result, and 4 piglets of control group are using same operation, spraying isodose
Physiological saline, record sneezing and cough number.All test swine rearings are in same environment, using same management mould
Formula is raised.Sneezing and cough number record result are as shown in table 4 and table 5.
Different time sections test pig sneezing number after the spray medication of the invention of table 4
As shown in Table 4:
4 pigs of experimental group make a call to 40 sneezes within 140s in total, 10 times average/only, before all concentrating in 100s,
There is no sneezing behaviors later.
4 pigs of control group make a call to 3 sneezes within 140s in total, average 0.75 time/only, before all concentrating on 20s it
Interior, there is no sneezing behaviors later.
Remarks: for physiological saline itself to schneiderian membrane without inductivity stimulation, the pig sneezing behavior of control group may be with
After physiological saline is spraying, schneiderian membrane is related by hydraulic pressure physical shock and irritability reaction.
Different time sections test pig cough number after the spray medication of the invention of table 5
As shown in Table 5:
4 pigs of experimental group occur 50 coughs, averagely 12.5 times/in total, all concentrate on preceding 120s within 140s
Interior, there is no cough behaviors later.
4 pigs of control group are within 140s, and 2 coughs occur in only 2-2 and 2-4, other two do not have cough behavior,
For entirety, average time is 0.5 time/, and before concentrating within 20s, there is no cough behaviors later.
Remarks: the pig cough behavior of effect of the physiological saline without induction pig cough itself, control group may be with physiological saline
After spraying, throat position is related by hydraulic pressure physical shock and irritability reaction.
The result shows that: the sneezing of test group piglet and cough number are significantly more than control group.
Conclusion (of pressure testing): a kind of spray for preventing newborn piglet asphyxia of the invention has significant induction newborn piglet
The effect of sneezing and cough.
Claims (5)
1. a kind of for preventing the spray of newborn piglet asphyxia, which is characterized in that the weight of every 100g spray forms are as follows: benzene pricks bromine
0.01~0.5g of ammonium, 0.05~2.0g of tannic acid, 0.01~3.0g of mustard oil, 2.0~6.0g of PLURONICS F87, emulsifier TX-
100 10.0~20.0g, 5.0~10.0g of isopropanol, surplus are deionized water.
2. as described in claim 1 a kind of for preventing the spray of newborn piglet asphyxia, which is characterized in that every 100g spray
Weight group becomes, and 0.1~0.3g of benzalkonium bromide, 0.5~1.5g of tannic acid, 0.1~2.0g of mustard oil, PLURONICS F87 3.0~
5.0g, 12.0~18.0g of emulsifier TX-100,7.0~9.0g of isopropanol, surplus is deionized water.
3. as claimed in claim 2 a kind of for preventing the spray of newborn piglet asphyxia, which is characterized in that every 100g spray
Weight composition are as follows: benzalkonium bromide 0.2g, tannic acid 1.0g, mustard oil 1.0g, PLURONICS F87 4.0g, emulsifier TX-100
15.0g, isopropanol 8.0g, deionized water 70.8g.
4. a kind of for preventing the spray of newborn piglet asphyxia as described in claims 1 or 2 or 3, which is characterized in that described to go
Ionized water is sterile deionized water.
5. claims 1 or 2 is 3 any described a kind of for preventing the preparation method of the spray of newborn piglet asphyxia, special
Sign is, comprising the following steps: PLURONICS F87 is added in emulsifier TX-100 by (a), is stirred continuously until poloxamer
188 are completely dissolved, and isopropanol is added, stirs evenly, obtains system A；(b) mustard oil is added in system A, is stirred evenly, obtained
System B；(c) after mixing tannic acid and benzalkonium bromide, the deionized water of surplus is added, makes it completely dissolved, obtains system C；(d) will
System C is added gradually in system B, and side edged emulsifies mixed system with mulser, and system can gradually become muddy by clarifying
It is turbid, ultimately form the uniform faint yellow opaque emulsion of quality, sealing packing to get.
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| CN110063976B CN110063976B (en) | 2021-07-20 |
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| US20060120967A1 (en) * | 2004-12-07 | 2006-06-08 | Qpharma, Llc | Solution forms of cyclodextrins for nasal or throat delivery of essential oils |
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| CN105640932A (en) * | 2016-01-07 | 2016-06-08 | 浙江医学高等专科学校 | Nasal spray and preparation method thereof |
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2019
- 2019-05-06 CN CN201910371373.2A patent/CN110063976B/en not_active Expired - Fee Related
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