CN110063328B - Vacuum biological sample storage device and biological sample storage method - Google Patents
Vacuum biological sample storage device and biological sample storage method Download PDFInfo
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- CN110063328B CN110063328B CN201910240676.0A CN201910240676A CN110063328B CN 110063328 B CN110063328 B CN 110063328B CN 201910240676 A CN201910240676 A CN 201910240676A CN 110063328 B CN110063328 B CN 110063328B
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- 239000012472 biological sample Substances 0.000 title claims abstract description 27
- 238000000034 method Methods 0.000 title claims abstract description 20
- 238000001802 infusion Methods 0.000 claims abstract description 80
- 238000007789 sealing Methods 0.000 claims abstract description 70
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims abstract description 54
- 238000005086 pumping Methods 0.000 claims abstract description 10
- 239000007788 liquid Substances 0.000 claims description 30
- 230000000903 blocking effect Effects 0.000 claims description 7
- 238000007689 inspection Methods 0.000 claims description 5
- 238000004891 communication Methods 0.000 claims description 2
- 239000002085 irritant Substances 0.000 abstract description 3
- 231100000021 irritant Toxicity 0.000 abstract description 3
- 239000000523 sample Substances 0.000 abstract description 3
- 239000000243 solution Substances 0.000 description 11
- 238000005303 weighing Methods 0.000 description 4
- 230000004308 accommodation Effects 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000013461 design Methods 0.000 description 2
- 240000007643 Phytolacca americana Species 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000003183 carcinogenic agent Substances 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0236—Mechanical aspects
- A01N1/0242—Apparatuses, i.e. devices used in the process of preservation of living parts, such as pumps, refrigeration devices or any other devices featuring moving parts and/or temperature controlling components
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- General Health & Medical Sciences (AREA)
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Abstract
The invention relates to the technical field of medical equipment, in particular to a vacuum biological sample storage device and a biological sample storage method. A vacuum biological specimen storage device comprising: storage box, holding box, sealing device, infusion set, evacuation pump. The storage box comprises an upper storage space and a lower storage space, and an electronic scale is arranged in the upper storage space; the accommodating box is arranged on a tray of the electronic scale; the sealing device is arranged above the accommodating box; the infusion device comprises: the infusion pump, the communicating pipe, the infusion pipe, the moving rod and the fixed rod II; the vacuum pumping pump is arranged in the lower storage space. The invention solves the risk of inhaling formaldehyde or other irritant vapors when traditional medical personnel manually handle the sample.
Description
Technical Field
The invention relates to the technical field of medical equipment, in particular to a vacuum biological sample storage device and a biological sample storage method.
Background
At present, the transportation of pathological samples or specimens after large hospital operations is mainly carried out by doctors to a pathology center through vacuum bags or separate specimen boxes, and the operation of the specimens which need to be vacuumized and soaked in formalin is more complicated.
The fixing solution of the specimen is formalin (aqueous solution of formaldehyde), and formaldehyde is a carcinogenic substance which is very volatile; in recent years, substitutes for formaldehyde have been developed, but the preservatives used at present have stimulating effects on human bodies and are harmful to human bodies. Conventional doctors manually handle samples, risking inhalation of formaldehyde or other irritant vapors when formalin is injected, and causing physical harm to the health workers.
Therefore, there is a need to design an apparatus for handling samples to address such hazards.
Disclosure of Invention
Therefore, the present invention has been made in view of the above problems, and the present invention solves the problem of the conventional medical staff inhaling formaldehyde or other irritant vapor when handling the sample manually by skillful design of the infusion device and the sealing device. The invention realizes the aim through the following technical scheme:
in one aspect of the invention, a vacuum biological specimen storage device includes: the device comprises a storage box, an accommodating box, a sealing device, a transfusion device and a vacuum pump;
the storage box comprises an upper storage space and a lower storage space, and an electronic scale is arranged in the upper storage space;
the accommodating box is a hollow cylinder, the top end of the accommodating box is open, a slope surface is arranged on the inner wall of the edge of the top end of the accommodating box, and the accommodating box is arranged on a tray of the electronic scale;
the sealing device is arranged above the accommodating box and comprises: the fixing rod I, the expansion cover, the lantern ring and the air cylinder are fixed on the fixing rod I;
the first fixing rod is arranged on the upper wall of the upper-layer storage space and above the accommodating box;
the expansion cover is arranged below the first fixing rod and extends into the containing box, the upper part of the expansion cover is a hard rod, the lower part of the expansion cover is a flexible rod, the hard rod is connected and arranged below the first fixing rod, the flexible rod is made of rubber, the flexible rod is in a circular truncated cone shape with a small upper end face and a large lower end face, a lantern ring is arranged on the flexible rod, the flexible rod is compressed into a cylindrical shape through the lantern ring, and the lantern ring drives the flexible rod to move up and down through an air cylinder;
the infusion device comprises: the infusion pump, the communicating pipe, the infusion pipe, the moving rod and the fixed rod II;
the infusion pump is arranged in the lower storage space;
one end of the communicating pipe is communicated with the infusion pump, and the other end of the communicating pipe extends into the upper storage space and is communicated with the infusion pipe;
the infusion tube is arranged above the accommodating box, and the bottom end of the infusion tube extends into the accommodating box;
the movable rod is arranged on one side of the infusion tube in parallel, the movable rod is fixedly connected with the infusion tube through a connecting rod, the movable rod extends into the containing box, the top end of the movable rod is open, the interior of the movable rod is hollow, and the movable rod is sleeved on a second fixing rod on the upper wall of the upper-layer storage space;
the vacuum pumping pump is arranged in the lower storage space, one end of the vacuum pumping pump is connected with the air duct, and one end of the air duct extends into the upper storage space.
In one embodiment, the bottom end of the travel bar is smooth hemispherical.
In one embodiment, after the flexible rod of the expansion cap expands to seal, a further wax seal is applied to the edge of the expansion cap that contacts the containment box.
In one embodiment, the containment box is sealed and the inflated cover is then ruptured if necessary to remove the specimen.
In one embodiment, the infusion tube is provided with a switch valve.
The invention also provides a biological sample storage method, and the vacuum biological sample storage device adopting the technical scheme comprises the following steps:
put biological sample into holding the box, the chamber door of storage box is closed completely.
And secondly, the vacuum pump starts to work, and air in the upper storage space is pumped away, so that the upper storage space reaches the required vacuum environment.
Thirdly, the electronic scale feeds the weighing back to the infusion device (the controller is not shown) through the controller, the infusion pump works, the quantitative formalin solution is guided into the storage box through the infusion tube, and then the infusion pump stops working.
And fourthly, the sealing device works, the air cylinder works to drive the lantern ring to move upwards, so that the flexible rod of the expansion cover gradually expands, the flexible rod is completely expanded after the lantern ring is completely separated from the flexible rod, the slope surface of the accommodating box is extruded by the inclined surface of the circular platform of the flexible rod, and the expansion cover is completely sealed. Meanwhile, in the process that the flexible rod of the expansion cover expands to be in a circular truncated cone shape, the circular truncated cone inclined surface of the flexible rod is abutted to the moving rod, so that the moving rod moves upwards along the second fixed rod, and the infusion tube is driven to move upwards.
And fifthly, removing the hard rod of the expansion cover from the first fixing rod to separate the expansion cover from the first fixing rod, and putting the sealed accommodating box into the specimen storage chamber to be inspected next.
In another aspect of the invention, a vacuum biological specimen storage device includes: the device comprises a storage box, a containing device, a sealed infusion device and a vacuum pump;
the storage box comprises an upper storage space and a lower storage space, and an electronic scale is arranged in the upper storage space;
the accommodating device is arranged on the electronic scale and comprises: an accommodating box and a box cover;
the accommodating box is a hollow cylinder, the top end of the accommodating box is open, and the accommodating box is arranged on a tray of the electronic scale;
the box cover is arranged on the accommodating box, an opening is formed in the top end of the box cover, a slope surface is arranged on the inner wall of the top end of the box cover at the edge of the opening, a flexible shifting piece is arranged at the position below the slope surface in the box cover, a protruding piece is arranged on the periphery of the box cover, and the protruding piece is arranged below the fixing pieces on the two side walls of the upper-layer storage space;
the sealed infusion device comprises: cylinder, sealing cover, liquid guide tube and liquid transfer pump;
the cylinder is arranged on the upper wall of the upper-layer storage space and is arranged above the accommodating device;
the sealing cover is formed by communicating a hollow round platform with a hollow pipe, a small hole is formed in the side wall of the hollow pipe, a rotating ring is sleeved on the periphery of the hollow pipe, a short pipe is arranged on the outer side wall of the rotating ring, a blocking block is arranged on the inner side wall of the rotating ring through a spring, the hollow pipe of the sealing cover is connected and arranged on a shaft of the air cylinder, the hollow round platform of the sealing cover is arranged in the box cover, and a plurality of liquid outlet holes are formed in the inclined plane of the hollow round;
one end of the liquid guide pipe is connected with the short pipe on the rotating ring, and the other end of the liquid guide pipe extends into the lower storage space and is communicated with the liquid conveying pump;
the vacuum pumping pump is arranged in the lower storage space, one end of the vacuum pumping pump is connected with the air duct, and one end of the air duct extends into the upper storage space.
In one embodiment, a rubber pad is arranged on one circle of the slope surface of the box cover.
In one embodiment, a plurality of protrusions corresponding to the liquid outlet holes are arranged on the slope surface of the box cover.
The invention also provides a biological sample storage method, and the vacuum biological sample storage device adopting the technical scheme comprises the following steps:
putting the biological specimen into a containing box, screwing a box cover, and completely closing a box door of a storage box.
And secondly, the vacuum pump starts to work, and air in the upper storage space is pumped away, so that the upper storage space reaches the required vacuum environment.
The electronic scale feeds back the weighing to the infusion device (the controller is not shown) through the controller, the infusion pump works, formalin solution is input into the sealing cover through the liquid guide pipe, and the formalin solution flows into the accommodating box along the liquid outlet hole on the edge of the sealing cover.
Treat that a certain amount of formalin solution flows into and holds the box after, the cylinder work drives sealed lid and shifts up to touch the plectrum and make the plectrum deformation, treats that sealed lid passes behind the plectrum, the plectrum reconversion, and the opening of lid is plugged up to sealed lid above the plectrum, and the inclined plane of the cavity round platform of sealed lid is corresponding with the slope of lid top inner wall, and the play liquid hole is plugged up.
Rotating the rotating ring until the blocking block rotates into the small hole, tightly locking the rotating ring, and staggering the small hole and the short pipe 8241 to block the short pipe and then removing the liquid guide pipe.
Sixthly, the sealing cover is removed from the shaft of the air cylinder, and the sealed accommodating box is placed into a specimen storage chamber to wait for the next inspection.
The invention has the following beneficial effects:
1. the infusion tube of the infusion device provided by the invention extends into the containing box, so that the formalin solution smoothly flows into the containing box, the formalin solution cannot splash and pollute the outside of the containing box, meanwhile, the sealing device is effectively matched with the infusion device, the infusion tube is successfully moved out while sealing is finished, manual intervention is not needed in the process, and the sample is safer to process.
2. The sealing device provided by the invention effectively realizes the sealing of the accommodating box through the matching of the expansion cover and the lantern ring.
Drawings
Fig. 1 is a schematic view of the overall structure of the storage box of the present invention.
Fig. 2 is a schematic view of the structural arrangement in the storage box of the present invention.
FIG. 3 is a schematic view showing the overall structure of the sealing device and the housing case when the expansion cap of the sealing device of the present invention is compressed.
FIG. 4 is a schematic view showing the overall structure of the sealing device and the accommodation box when the expansion cap of the sealing device of the present invention is expanded.
FIG. 5 is a schematic sectional view showing the sealing device and the housing case when the expansion cap of the sealing device of the present invention is compressed.
FIG. 6 is a schematic sectional view showing the sealing device and the accommodation box when the expansion cap of the sealing device of the present invention is expanded.
Fig. 7 is a schematic view showing the structure of the sealing device when the expansion cap of the sealing device of the present invention is expanded.
Fig. 8 is a schematic view of the infusion device of the present invention.
Fig. 9 is a schematic view of the arrangement of the structure in the storage box according to another embodiment of the present invention.
Fig. 10 is a schematic view of the overall structure of a containment device and a sealed infusion device in accordance with another embodiment of the invention.
Fig. 11 is a schematic view of the overall structure of a receiving device according to another embodiment of the present invention.
Fig. 12 is a detailed schematic view of a containment device according to another embodiment of the present invention.
Fig. 13 is a schematic cross-sectional view of a containment device and a sealed infusion device in accordance with another embodiment of the invention.
Fig. 14 is a schematic view of a sealed infusion device in accordance with another embodiment of the invention.
Fig. 15 is a detailed view of the hollow tube of a sealed infusion device in accordance with another embodiment of the invention.
Detailed Description
Preferred embodiments of the present invention will be described in detail with reference to the accompanying drawings, so that those embodiments can be easily implemented by those having ordinary skill in the art to which the present invention pertains. However, the present invention may be embodied in many different forms and is not limited to the embodiments described below. In addition, in order to more clearly describe the present invention, components not connected to the present invention will be omitted from the drawings.
Example one
As shown in fig. 1-2, a vacuum biological specimen storage device, comprising: the device comprises a storage box 1, an accommodating box 2, a sealing device 3, a transfusion device 4 and a vacuum pump 5;
the storage box 1 comprises an upper storage space 11 and a lower storage space 12, and an electronic scale 13 is arranged in the upper storage space 11;
as shown in fig. 3-7, the accommodating box 2 is a hollow cylinder, the top end of the accommodating box 2 is open, a slope 21 is arranged on the inner wall of the top end edge of the accommodating box 2, and the accommodating box 2 is arranged on a tray of the electronic scale 13;
said sealing means 3 are arranged above the containing box 2, the sealing means 3 comprising: the fixing rod I31, the expansion cover 32, the lantern ring 33 and the air cylinder 34;
the first fixing rod 31 is arranged on the upper wall of the upper storage space 11 and is arranged at the central position above the accommodating box 2;
the expansion cover 32 is arranged below the first fixing rod 31 and extends into the accommodating box 2, the upper portion of the expansion cover 32 is a hard rod 321, the lower portion of the expansion cover is a flexible rod 322, the hard rod 321 is connected and arranged below the first fixing rod 31, the flexible rod 322 is made of rubber, the flexible rod 322 is in a circular truncated cone shape with a small upper end face and a large lower end face, a lantern ring 33 is arranged on the flexible rod 322, the flexible rod 322 is compressed into a cylindrical shape through the lantern ring 33, the lantern ring 33 is driven to move up and down through an air cylinder 34, the air cylinder 34 stretches and drives the lantern ring 33 to move up and down, and therefore expansion or compression of the flexible rod 322 of the expansion cover 32;
as shown in fig. 8, the infusion device 4 includes: an infusion pump 41, a communication pipe 42, an infusion tube 43, a moving rod 44 and a second fixing rod 45;
the infusion pump 41 is arranged in the lower storage space 12;
one end of the communicating pipe 42 is communicated with the infusion pump 41, and the other end extends into the upper storage space 11 and is communicated with the infusion pipe 43;
the infusion tube 43 is arranged above the accommodating box 2, and the bottom end of the infusion tube 43 extends into the accommodating box 2;
the movable rod 44 is arranged on one side of the infusion tube 43 in parallel, the movable rod 44 is fixedly connected with the infusion tube 43 through a connecting rod, the movable rod 44 extends into the accommodating box 2, the top end of the movable rod 44 is open, the interior of the movable rod 44 is hollow, the movable rod 44 is sleeved on a second fixing rod 45 on the upper wall of the upper-layer storage space 11, and in the process that the flexible rod 322 of the expansion cover 32 expands to be in a circular truncated cone shape, the inclined surface of the circular truncated cone of the flexible rod 322 abuts against the movable rod 44, so that the movable rod 44 moves upwards along the second fixing rod 45, and the infusion tube 43 is driven;
as shown in fig. 2, the evacuation pump 5 is disposed in the lower storage space 12, one end of the evacuation pump 5 is connected to an air duct 51, and one end of the air duct 51 extends into the upper storage space 11.
As shown in fig. 8, preferably, as an implementation mode, the bottom end of the moving rod 44 is smooth and hemispherical, and this arrangement makes the moving rod 44 move upward better when the truncated cone inclined surface of the flexible rod 322 abuts against the moving rod 44 during the expansion of the flexible rod 322 of the expansion cover 32 into the truncated cone shape.
Preferably, as an implementation mode, after the flexible rod 322 of the expansion cover 32 is expanded and sealed, the edge of the expansion cover 32 contacting with the accommodating box 2 is further wax-sealed, and this arrangement makes the overall sealing effect of the expansion cover 32 better.
Preferably, as an implementation mode, after the accommodating box 2 is sealed, if the specimen is required to be taken out, the expansion cover 32 is cut open, and after the specimen is taken out, the accommodating box 2 can be reused after being sterilized, and only the expansion cover 32 needs to be replaced again.
As shown in fig. 8, as an embodiment, the infusion tube 43 is preferably provided with an on-off valve 431, which can control the on-off of the infusion tube 43 and the flow rate of the infusion in time, thereby effectively controlling the amount of formalin to be used.
The invention also provides a biological sample storage method, and the vacuum biological sample storage device adopting the technical scheme comprises the following steps:
put the biological sample into the containing box 2, and the door of the storage box 1 is completely closed.
And secondly, the vacuum pumping pump 5 starts to work, and air in the upper storage space 11 is pumped away, so that the upper storage space 11 reaches the required vacuum environment.
Thirdly, the electronic scale 13 feeds the weighing back to the infusion device 4 through the controller (the controller is not shown), the infusion pump 41 works, the quantitative formalin solution is guided into the storage box through the infusion tube 43, and then the infusion pump 41 stops working.
And fourthly, the sealing device 3 works, the two cylinders 34 move upwards to drive the lantern ring 33 to move upwards, so that the flexible rod 322 of the expansion cover 32 gradually expands, when the lantern ring 33 is completely separated from the flexible rod 322, the flexible rod 322 completely expands, the slope 21 of the accommodating box 2 is extruded by the inclined plane of the circular table of the flexible rod 322, and the expansion cover 32 is completely sealed. Meanwhile, in the process that the flexible rod 322 of the expansion cover 32 expands to be in the shape of a circular truncated cone, the circular truncated cone inclined surface of the flexible rod 322 abuts against the moving rod 44, so that the moving rod 44 moves upwards along the second fixed rod 45, and the infusion tube 43 is driven to move upwards.
Fifthly, the hard rod 321 of the expansion cover 32 is removed from the first fixing rod 31, so that the expansion cover 32 is separated from the first fixing rod 31, and the sealed accommodating box 2 is placed in the specimen storage chamber for next inspection.
Example two
As shown in fig. 9, a vacuum biological sample storage device includes: a storage box 6, a containing device 7, a sealed infusion device 8 and a vacuum pump 9;
the storage box 6 comprises an upper storage space 61 and a lower storage space 62, and an electronic scale 63 is arranged in the upper storage space 61;
as shown in fig. 10 to 13, the accommodating unit 7 is provided on an electronic scale 63, and the accommodating unit 7 includes: the accommodation box 71, the box cover 72;
the accommodating box 71 is a hollow cylinder, the top end of the accommodating box is open, and the accommodating box 71 is arranged on a tray of the electronic scale 63;
the box cover 72 is arranged on the accommodating box 71, the top end of the box cover 72 is provided with an opening 721, the inner wall of the top end of the box cover 72 at the edge of the opening 721 is provided with a slope surface 722, a flexible poking sheet 723 is arranged at a position below the slope surface 722 inside the box cover 72, a convex sheet 724 is arranged on the periphery of the box cover 72, and the convex sheet 724 is arranged below the fixing sheets 64 on the two side walls of the upper-layer storage space 61;
as shown in fig. 14-15, the sealed infusion device 8 includes: a cylinder 81, a seal cover 82, a catheter 83, and an infusion pump 84;
the cylinder 81 is arranged on the upper wall of the upper storage space 61 and is arranged at the central position above the accommodating device 7;
the sealing cover 82 is formed by communicating a hollow round table 821 and a hollow tube 822, the hollow tube 822 of the sealing cover 82 is connected and arranged on the shaft of the air cylinder 81, a small hole 8221 is arranged on the side wall of the hollow tube 822, a rotating ring 824 is sleeved on the periphery of the hollow tube 822, a short tube 8241 is arranged on the outer side wall of the rotating ring 824, a blocking block 8242 is arranged on the inner side wall of the rotating ring through a spring, the small hole 8221 and the short tube 8241 are corresponding or staggered to control the connection and disconnection of the short tube 8241 through rotating the rotating ring 824, when the blocking block 8242 rotates into the small hole 8221, the rotating ring 824 is tightly locked, the hollow round table 821 of the sealing cover 82 is arranged in the box cover 72, a plurality of liquid outlet holes 823 are arranged on the inclined plane of the hollow round table 821 of the sealing cover 82, the air cylinder 81 drives the sealing cover 82 to move upwards, so that the sealing cover 82 blocks an opening 721 at the top end of the box, thereby allowing the sealing cover 82 to better penetrate the poke piece 723;
one end of the liquid guide pipe 83 is connected with a short pipe 8241 on the rotating ring 824, and the other end extends into the lower storage space 62 and is communicated with the liquid conveying pump 84;
as shown in fig. 9, the evacuation pump 9 is disposed in the lower storage space 62, one end of the evacuation pump 9 is connected to the air duct 91, and one end of the air duct 91 extends into the upper storage space 61.
Preferably, as an implementation manner, a rubber pad is arranged on the slope surface 722 of the box cover 72 for one circle, when the sealing cover 82 moves upwards, the slope surface of the hollow round platform 821 of the sealing cover 82 corresponds to the slope surface 722 of the top end inner wall of the box cover 72, and the rubber pad further improves the sealing effect of the sealing cover 82.
Preferably, as an implementation manner, the slope surface 722 of the box cover 72 is provided with a plurality of protrusions corresponding to the liquid outlet holes 823, and when the slope surface of the hollow round platform 821 of the sealing cover 82 corresponds to the slope surface 722 of the inner wall of the top end of the box cover 72, the protrusions on the slope surface 722 are correspondingly inserted into the liquid outlet holes 823, so as to further improve the sealing effect of the sealing cover 82.
The invention also provides a biological sample storage method, and the vacuum biological sample storage device adopting the technical scheme comprises the following steps:
put the biological specimen into the housing box 71, screw the box cover 72, and then completely close the door of the storage box 6.
Secondly, the vacuum pump 9 starts to work, and air in the upper storage space 61 is pumped away, so that the upper storage space 61 reaches the required vacuum environment.
Thirdly, the electronic scale 63 feeds the weighing back to the infusion device (the controller is not shown) through the controller, the infusion pump 84 works, the formalin solution is input into the sealing cover 82 through the liquid guide pipe 83, and the formalin solution flows into the accommodating box 71 along the liquid outlet hole 823 on the edge of the sealing cover 82.
Fourthly, after a certain amount of formalin solution flows into the containing box 71, the air cylinder 81 works to drive the sealing cover 82 to move upwards to touch the shifting piece 723 so as to deform the shifting piece 723, after the sealing cover 82 penetrates through the shifting piece 723, the shifting piece 723 restores to the original state, the sealing cover 82 blocks the opening 721 of the box cover 72 above the shifting piece 723, the inclined surface of the hollow round table 821 of the sealing cover 82 corresponds to the inclined surface 722 of the inner wall of the top end of the box cover 72, and the liquid outlet hole 823 is blocked.
Fifthly, the rotating ring 824 is rotated until the blocking piece 8242 rotates into the small hole 8221, the rotating ring 824 is tightly locked, the small hole 8221 is staggered with the short pipe 8241, so that the short pipe 8241 is blocked, and then the liquid guide pipe 83 is removed.
Sixthly, the sealing cover 82 is removed from the shaft of the air cylinder 81, and the sealed accommodating box 71 is placed into a specimen storage chamber to wait for the next inspection.
Claims (10)
1. A vacuum biological sample storage device comprises a storage box (1), an accommodating box (2), a sealing device (3), an infusion device (4) and a vacuum pump (5);
the storage box (1) comprises an upper storage space (11) and a lower storage space (12), and an electronic scale (13) is arranged in the upper storage space (11);
the vacuum-pumping pump (5) is arranged in the lower-layer storage space (12), one end of the vacuum-pumping pump (5) is connected with the air duct (51), and one end of the air duct (51) extends into the upper-layer storage space (11);
the method is characterized in that: the accommodating box (2) is a hollow cylinder, the top end of the accommodating box is open, a slope surface (21) is arranged on the inner wall of the edge of the top end of the accommodating box (2), and the accommodating box (2) is arranged on a tray of the electronic scale (13);
the sealing device (3) is arranged above the accommodating box (2), and the sealing device (3) comprises: the device comprises a first fixing rod (31), an expansion cover (32), a lantern ring (33) and a cylinder (34);
the first fixing rod (31) is arranged on the upper wall of the upper-layer storage space (11) and is arranged above the accommodating box (2);
the expansion cover (32) is arranged below the first fixing rod (31) and extends into the accommodating box (2), the upper portion of the expansion cover (32) is a hard rod (321), the lower portion of the expansion cover is a flexible rod (322), the hard rod (321) is connected and arranged below the first fixing rod (31), the flexible rod (322) is made of rubber, the flexible rod (322) is in a circular table shape with a small upper end face and a large lower end face, a lantern ring (33) is arranged on the flexible rod (322), the flexible rod (322) is compressed into a cylindrical shape through the lantern ring (33), and the lantern ring (33) is driven by an air cylinder (34) to move up and down;
the infusion device (4) comprises: an infusion pump (41), a communication pipe (42), an infusion tube (43), a moving rod (44) and a second fixing rod (45);
the infusion pump (41) is arranged in the lower storage space (12);
one end of the communicating pipe (42) is communicated with the infusion pump (41), and the other end of the communicating pipe extends into the upper storage space (11) and is communicated with the infusion pipe (43);
the infusion tube (43) is arranged above the accommodating box (2), and the bottom end of the infusion tube (43) extends into the accommodating box (2);
the movable rod (44) is arranged on one side of the infusion tube (43) in parallel, the movable rod (44) is fixedly connected with the infusion tube (43) through a connecting rod, the movable rod (44) extends into the accommodating box (2), the top end of the movable rod (44) is open, the interior of the movable rod is hollow, and the movable rod (44) is sleeved on a second fixing rod (45) on the upper wall of the upper-layer storage space (11).
2. The vacuum biological specimen storage device of claim 1, wherein: the bottom end of the moving rod (44) is smooth and hemispherical.
3. The vacuum biological specimen storage device of claim 2, wherein: after the flexible rod (322) of the expansion cover (32) is expanded and sealed, the edge of the expansion cover (32) contacting with the accommodating box (2) is further wax-sealed.
4. The vacuum biological specimen storage device of claim 3, wherein: the accommodating box (2) is sealed, and the expansion cover (32) is cut open if the specimen needs to be taken out.
5. The vacuum biological specimen storage device of claim 4, wherein: an on-off valve (431) is arranged on the infusion tube (43).
6. A biological sample storage method, characterized by: a vacuum biological sample storage device according to any one of claims 1 to 5, wherein the biological sample is stored by the following method:
firstly, placing a biological specimen into a containing box (2), and completely closing a box door of a storage box (1);
secondly, the vacuum pump (5) starts to work, and air in the upper storage space (11) is pumped away, so that the upper storage space (11) achieves a required vacuum environment;
thirdly, the electronic scale (13) feeds the weighed quantity back to the infusion device (4) through the controller, the infusion pump (41) works, the quantitative formalin solution is guided into the storage box through the infusion tube (43), and then the infusion pump (41) stops working;
the sealing device (3) works, the air cylinder (34) works to drive the lantern ring (33) to move upwards, so that the flexible rod (322) of the expansion cover (32) gradually expands, when the lantern ring (33) is completely separated from the flexible rod (322), the flexible rod (322) is completely expanded, the slope surface (21) of the accommodating box (2) is extruded by the inclined surface of the circular table of the flexible rod (322), and the expansion cover (32) is completely sealed; meanwhile, in the process that the flexible rod (322) of the expansion cover (32) expands to be in a circular truncated cone shape, the circular truncated cone inclined surface of the flexible rod (322) abuts against the moving rod (44), so that the moving rod (44) moves upwards along the second fixing rod (45), and the infusion tube (43) is driven to move upwards;
and fifthly, removing the hard rod (321) of the expansion cover (32) from the first fixing rod (31) to separate the expansion cover (32) from the first fixing rod (31), and placing the sealed accommodating box (2) into the specimen storage chamber for next inspection.
7. A vacuum biological sample storage device comprises a storage box (6), an accommodating device (7), a sealing infusion device (8) and a vacuum pump (9);
the storage box (6) comprises an upper-layer storage space (61) and a lower-layer storage space (62), and an electronic scale (63) is arranged in the upper-layer storage space (61);
the vacuum pumping pump (9) is arranged in the lower-layer storage space (62), one end of the vacuum pumping pump (9) is connected with the air duct (91), and one end of the air duct (91) extends into the upper-layer storage space (61);
the method is characterized in that: the containing device (7) is arranged on an electronic scale (63), and the containing device (7) comprises: an accommodating box (71) and a box cover (72);
the accommodating box (71) is a hollow cylinder, the top end of the accommodating box is open, and the accommodating box (71) is arranged on a tray of the electronic scale (63);
the box cover (72) is arranged on the accommodating box (71), the top end of the box cover (72) is provided with an opening (721), the inner wall of the top end of the box cover (72) at the edge of the opening (721) is provided with a slope surface (722), a toughness shifting sheet (723) is arranged at the position below the slope surface (722) in the box cover (72), a convex sheet (724) is arranged on the periphery of the box cover (72), and the convex sheet (724) is arranged below the fixing sheets (64) on the two side walls of the upper-layer storage space (61);
the sealed infusion device (8) comprises: a cylinder (81), a sealing cover (82), a liquid guide pipe (83) and an infusion pump (84);
the air cylinder (81) is arranged on the upper wall of the upper-layer storage space (61) and is arranged above the accommodating device (7);
the sealing cover (82) is formed by communicating a hollow round table (821) with a hollow pipe (822), a small hole (8221) is formed in the side wall of the hollow pipe (822), a rotating ring (824) is sleeved on the periphery of the hollow pipe (822), a short pipe (8241) is arranged on the outer side wall of the rotating ring (824), a blocking block (8242) is arranged on the inner side wall of the rotating ring through a spring, the hollow pipe (822) of the sealing cover (82) is connected and arranged on the shaft of the cylinder (81), the hollow round table (821) of the sealing cover (82) is arranged in the box cover (72), and a plurality of liquid outlet holes (823) are formed in the inclined plane of the hollow round table (821) of the sealing cover;
one end of the liquid guide pipe (83) is connected with a short pipe (8241) on the rotating ring (824), and the other end of the liquid guide pipe extends into the lower storage space (62) and is communicated with the liquid conveying pump (84).
8. The vacuum biological specimen storage device of claim 7, wherein: a rubber pad is arranged on the periphery of the slope surface (722) of the box cover (72).
9. The vacuum biological specimen storage device of claim 8, wherein: the slope surface (722) of the box cover (72) is provided with a plurality of bulges corresponding to the liquid outlet holes (823).
10. A biological sample storage method, characterized by: a vacuum biological sample storage device according to any one of claims 7 to 9, wherein the biological sample is stored by the following method:
firstly, placing a biological specimen into a containing box (71), screwing a box cover (72), and then completely closing a box door of a storage box (6);
secondly, the vacuum pump (9) starts to work, and air in the upper storage space (61) is pumped away, so that the upper storage space (61) achieves a required vacuum environment;
thirdly, the electronic scale (63) feeds the weighed quantity back to the infusion device through the controller, the infusion pump (84) works, formalin solution is input into the sealing cover (82) through the liquid guide pipe (83), and the formalin solution flows into the containing box (71) along the liquid outlet hole (823) on the edge of the sealing cover (82);
fourthly, after a certain amount of formalin solution flows into the containing box (71), the air cylinder (81) works to drive the sealing cover (82) to move upwards to touch the poking piece (723) to deform the poking piece (723), after the sealing cover (82) penetrates through the poking piece (723), the poking piece (723) restores to the original state, the sealing cover (82) blocks an opening (721) of the box cover (72) above the poking piece (723), the inclined surface of the hollow round table (821) of the sealing cover (82) corresponds to the inclined surface (722) of the inner wall of the top end of the box cover (72), and the liquid outlet hole (823) is blocked;
rotating the rotating ring (824) until the blocking block (8242) rotates into the small hole (8221), tightly locking the rotating ring (824), staggering the small hole (8221) and the short pipe (8241) so as to block the short pipe (8241), and then removing the liquid guide pipe (83);
sixthly, the sealing cover (82) is removed from the shaft of the air cylinder (81), and the sealed accommodating box (71) is placed into a specimen storage chamber to wait for the next inspection.
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| CN201910240676.0A CN110063328B (en) | 2019-03-28 | 2019-03-28 | Vacuum biological sample storage device and biological sample storage method |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1911684A1 (en) * | 2005-08-04 | 2008-04-16 | Olympus Corporation | Sample container |
| CN204674860U (en) * | 2015-03-11 | 2015-09-30 | 丹阳市第二人民医院 | Switch cabinet during medical operation sample soaks |
| CN206897257U (en) * | 2017-06-21 | 2018-01-19 | 上海于泽生物科技有限公司 | A kind of sample liquid storage bottler placer |
-
2019
- 2019-03-28 CN CN201910240676.0A patent/CN110063328B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1911684A1 (en) * | 2005-08-04 | 2008-04-16 | Olympus Corporation | Sample container |
| CN204674860U (en) * | 2015-03-11 | 2015-09-30 | 丹阳市第二人民医院 | Switch cabinet during medical operation sample soaks |
| CN206897257U (en) * | 2017-06-21 | 2018-01-19 | 上海于泽生物科技有限公司 | A kind of sample liquid storage bottler placer |
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| CN110063328A (en) | 2019-07-30 |
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