CN106344944B

CN106344944B - Pulsation sterilization equipment

Info

Publication number: CN106344944B
Application number: CN201610776392.XA
Authority: CN
Inventors: 刘万忠
Original assignee: HUBEI HOPE PHARMACEUTICAL CO Ltd
Current assignee: HUBEI HOPE PHARMACEUTICAL CO Ltd
Priority date: 2016-08-30
Filing date: 2016-08-30
Publication date: 2020-05-05
Anticipated expiration: 2036-08-30
Also published as: CN106344944A

Abstract

The application discloses pulsation sterilization equipment, pulsation sterilization equipment includes: the invention can pump the air in the sterilization box body, the liquid storage system and the separation drying system out to form vacuum through the vacuum system, and because the boiling point of the disinfectant is reduced under the vacuum condition and the disinfectant is easier to volatilize, the atomization effect and the drying efficiency of the disinfectant are greatly improved, the atomized particles are smaller and even reach the nanometer level, and are closer to the size of bacteria, so the disinfectant can be suspended in the air for a long time and fully contacted with the bacteria in the air to achieve the sterilization purpose; the invention has reasonable design, simple structure, convenient operation and lower cost, and can not only sterilize the small-sized sealable sterilization box body, but also sterilize various objects which are difficult to sterilize, such as various small-sized pipelines, small-sized containers and the like placed in the sterilization box body.

Description

Pulsation sterilization equipment

Technical Field

The invention relates to the field of sanitation and disinfection, in particular to pulse sterilization equipment.

Background

It is well known that most plastics are not resistant to high temperatures and corrosion, as are the various pipes and packaging containers made from these plastics. When these plastic materials are used as packaging materials for foods and medicines (e.g., eye drops bottles) and medical instruments (e.g., various endoscopes, disposable syringes, etc.), they must be sterilized.

At present, the sterilization methods for various kinds of non-high temperature resistant cavities, plastic pipes and plastic containers (such as plastic catheters, disposable syringes, plastic bottles and the like) include an ethylene oxide method, a circulating steam method, a chemical disinfectant cleaning method, an ultraviolet irradiation method, an ozone sterilization method, a Vaporized Hydrogen Peroxide (VHP) sterilization method and the like. These methods have respective advantages and disadvantages: the ethylene oxide sterilization effect is the most reliable, but the ethylene oxide has strong affinity with plastics, the residues are difficult to remove, the requirement on equipment is high, and the toxic effect on the environment is also large; the chemical disinfectant cleaning method is troublesome to operate, needs to be cleaned one by one, and is difficult to achieve the effect of complete sterilization; the ultraviolet irradiation method has very limited effect, and the ultraviolet rays are easily shielded and influenced by objects to form irradiation dead angles, so the disinfection effect is difficult to be confident. The sterilization result of the steam circulation method is satisfactory, but if the temperature and the pressure of the steam are not controlled properly, the plastic material is easy to deform. Ozone disinfection results are reliable, operation is simple, but ozone has strong oxidizability, and besides gold and platinum, ozone has a corrosive effect on almost all other metals, particularly aluminum, zinc and lead, and also has a strong corrosive effect on non-metallic materials, so that even if very stable materials such as polyvinyl chloride plastics and rubber used as sealing materials are used in other places, ozone is easily oxidized; although the vaporized hydrogen peroxide sterilization method can achieve the sterilization effect, the use of high-concentration hydrogen peroxide (more than 30 percent) is very dangerous, has strong corrosiveness and is very expensive in the used equipment. Therefore, there is a lack of a suitable sterilization apparatus for sterilization.

Disclosure of Invention

In order to solve the problem that the prior art lacks a proper sterilization device, the embodiment of the invention provides a pulse sterilization device. The technical scheme is as follows:

a pulse sterilizing apparatus, comprising: stock solution system, separation drying system, detecting system, spraying system, vacuum system, sterilization box and control system, separation drying system is located stock solution system top, just separation drying system with stock solution headtotail, the stock solution system is used for depositing disinfectant, separation drying system with the sterilization box spraying system connects in order, spraying system still with separation drying system the stock solution headtotail respectively, the sterilization box still with detecting system the vacuum system is connected respectively, control system with spraying system the vacuum system the detecting system all connects.

Preferably, the liquid storage system comprises a liquid storage device and a liquid conveying pipe, disinfectant is stored in the liquid storage device, the top of the liquid storage device is connected with the separation drying system, a liquid discharging hole is formed in the bottom of the liquid storage device, one end of the liquid conveying pipe is connected with the liquid discharging hole, and the other end of the liquid conveying pipe is connected with the spraying system.

Preferably, the spraying system comprises a fan, a venturi tube and a spraying head, the sterilizing box body is sequentially connected with the fan, the venturi tube, the spraying head and the separation and drying system, and the venturi tube is further connected with the infusion tube.

Preferably, the separation and drying system comprises at least one cavity inside, the side part of the cavity is connected with the spray head, and the bottom part of the cavity is connected with the liquid storage device.

Preferably, the separation and drying system comprises a first cavity, a second cavity and a third cavity which are connected in sequence, the bottom of the first cavity is connected with the liquid storage device, the side part of the first cavity is connected with the atomizing spray head, the third cavity is further connected with the sterilization box body, an opening is formed in the top of the third cavity, a sealing cover is arranged on the opening, and the bottom of the third cavity is connected with the first cavity or the liquid storage device.

Preferably, the sterilization box body comprises a box body and a support, wherein a plurality of supports are arranged in the box body, and the supports are used for placing objects to be sterilized.

Further, the sterilization box body further comprises a breathing filter and a vacuum meter, the breathing filter is located outside the box body, and the breathing filter and the vacuum meter are connected with the box body.

Preferably, the vacuum system comprises a vacuum pump and a vacuum pipe with negative pressure resistance which are connected in sequence, and the vacuum pipe is further connected with the box body.

Preferably, the detection system comprises a sensing device, a signal processing device and a display device which are connected in sequence, the sensing device is connected with the box body, and the sensing device is further connected with the spraying system.

Further, the pulsation sterilization equipment also comprises at least one shell, and the liquid storage system, the separation drying system, the sterilization box body, the spraying system and the control system are all arranged inside the shell.

The technical scheme provided by the embodiment of the invention has the following beneficial effects:

the invention can pump the air in the sterilization box body, the liquid storage system and the separation drying system out to form vacuum through the vacuum system, spray the disinfectant into small particles through the spraying system, inject the small particles into the separation drying system for separation and drying to form dry nano mist, inject the dry nano mist into the sterilization box body for sterilization, and then return the sterilization box body to the spraying system for circulation; because the boiling point of the disinfectant is reduced under the vacuum condition, the disinfectant is easier to volatilize, the atomization effect and the drying efficiency of the disinfectant are greatly improved, the atomized particles are smaller and even reach the nanometer level, and the size of the atomized particles is closer to that of bacteria, so the disinfectant can be suspended in the air for a long time and fully contacted with the bacteria in the air to achieve the aim of sterilization; the invention has reasonable design, simple structure, convenient operation and lower cost, and can sterilize not only the small-sized sealable box body, but also various objects which are difficult to sterilize, such as various small-sized pipelines, small-sized containers and the like placed in the box body.

Drawings

FIG. 1 is a schematic structural diagram of a pulse sterilizing apparatus provided by an embodiment of the present invention;

wherein: 1 a liquid storage system, 11 liquid storage devices, 12 liquid discharge holes, 13 liquid conveying pipes,

2 spraying system, 21 blower fan, 22 Venturi tube, 23 spraying head,

3 a sterilization box body, 31 a box body, 32 a bracket, 33 a breathing filter,

4, a vacuum system is adopted to carry out vacuum treatment,

5, a shell is arranged on the outer side of the shell,

6 a separation and drying system, 61 a first cavity, 62 a second cavity, 63 a third cavity,

7 detecting the system.

Detailed Description

The present application will be described in detail with reference to examples, but the present application is not limited to these examples.

As shown in fig. 1, an embodiment of the present invention provides a pulse sterilizing apparatus, including: stock solution system 1, separation drying system 6, detecting system 7, spraying system 2, vacuum system 4, sterilization box 3 and control system, separation drying system 6 is located stock solution system 1 top, just separation drying system 6 with stock solution system 1 is connected, stock solution system 1 is used for depositing disinfectant, separation drying system 6 with sterilization box 3 spraying system 2 connects in order, spraying system 2 still with separation drying system 6 stock solution system 1 connects respectively, sterilization box 3 still with detecting system 7 vacuum system 4 connects respectively, control system with spraying system 2 vacuum system 4 detecting system 7 all connects.

Wherein, the control system generally adopts a PLC program control system. The upper part of the separation drying system 6 is provided with a nano mist output port which is communicated with a nano mist injection port of the sterilization box body 3 through a pipeline; the vacuum system 4 is communicated with the inside of the sterilization box body 3 through a pipeline, the separation drying system 6 is sequentially connected with the sterilization box body 3, the spraying system 2 and the separation drying system 6 to form a circulation, air in the sterilization box body 3, the liquid storage system 1 and the separation drying system 6 is pumped out through the vacuum system 4 to form a vacuum, and finally a circulation loop capable of performing disinfection and sterilization under a vacuum condition is formed; spraying the disinfectant into small particles through a spraying system 2, injecting the small particles into a separation and drying system 6 for separation and drying to form dry nano mist, injecting the dry nano mist into a sterilization box body 3 for sterilization, and returning the dry nano mist into the spraying system 2 for circulation; because the boiling point of the disinfectant is reduced under the vacuum condition, the disinfectant is easier to volatilize, the atomization effect and the drying efficiency of the disinfectant are greatly improved, the atomized particles are smaller and even reach the nanometer level (below 0.1 micrometer) and are closer to the size of bacteria, and therefore the disinfectant can be suspended in the air for a long time and fully contact with the bacteria in the air to achieve the sterilization purpose; moreover, the invention has reasonable design, simple structure, convenient operation and lower cost, and can not only sterilize the small-sized sealable sterilization box body 3, but also sterilize various objects which are difficult to sterilize, such as various small-sized pipelines, small-sized containers and the like placed in the sterilization box body 3.

As shown in fig. 1, preferably, the liquid storage system 1 includes a liquid storage 11 and a liquid transport tube 13, the disinfectant is stored in the liquid storage 11, the top of the liquid storage 11 is connected to the separation and drying system 6, a liquid discharge hole 12 is formed in the bottom of the liquid storage 11, one end of the liquid transport tube 13 is connected to the liquid discharge hole 12, and the other end of the liquid transport tube 13 is connected to the spraying system 2. The infusion tube 13 is also provided with an opening, and the opening is connected with a two-way valve for liquid drainage or liquid feeding.

As shown in fig. 1, it is preferable that the spraying system 2 includes a fan 21, a venturi tube 22, and a spray head 23, the sterilization case 3 is connected in sequence to the fan 21, the venturi tube 22, the spray head 23, and the separation and drying system 6, and the venturi tube 22 is further connected to the infusion tube 13. Wherein, under the action of the blower 21, the disinfectant in the liquid storage 11 is sucked into the spraying system 2 through the liquid conveying pipe 13 for spraying. The fan 21 is a high-speed hot air fan 21.

As shown in fig. 1, the separation and drying system 6 preferably comprises at least one cavity inside, the side of said cavity being connected to the spray head 23 and the bottom of said cavity being connected to the reservoir 11.

As shown in fig. 1, the separation and drying system 6 preferably includes a first cavity 61, a second cavity 62, and a third cavity 63 connected in sequence, wherein the bottom of the first cavity 61 is connected to the liquid reservoir 11, the side of the first cavity 61 is connected to the spray head 23, the third cavity 63 is further connected to the sterilization box 3, an opening is formed at the top of the third cavity 63, a sealing cover is disposed on the opening, and the bottom of the third cavity 63 is connected to the first cavity 61 or the liquid reservoir 11.

In the embodiment of the invention, when three cavities are included, the top and the bottom of each cavity are provided with openings, the cavities are connected in series through pipelines or partition plates with the openings, the two cavities can be in an integrated structure or connected in other modes, and the openings arranged in the last 1 cavity connected with the sterilization box body 3 are used as the final outlet of the nano-mist;

the last third cavity 63 is extended to a nano mist output port through a pipeline and communicated with a nano mist injection port of the sterilization box body 3 through a pipeline and a two-way valve; the bottom of the third cavity 63 can be further provided with a small hole which is communicated with the first cavity 61 or the liquid storage device 11 through a pipeline, the top of the third cavity 63 is provided with an opening of a sealing cover, and the first cavity 61 or the liquid storage device 11 can be further provided with an opening which can be used as a disinfectant adding port so that the added disinfectant can flow into the liquid storage device 11 without residue; additional openings in other cavities of the separation and drying system 6 or in the reservoir 11 may be provided with disinfectant.

As shown in fig. 1, the sterilization box 3 preferably includes a box body 31 and a plurality of brackets 32, wherein the plurality of brackets 32 are disposed inside the box body 31, and the brackets 32 are used for placing objects to be sterilized.

As shown in fig. 1, the sterilization box 3 further includes a breathing filter 33 and a vacuum gauge, the breathing filter 33 is located outside the box body 31, the breathing filter 33 is connected to the box body 31, and the vacuum gauge is connected to the box body 31.

As shown in fig. 1, the vacuum system 4 preferably includes a vacuum pump and a vacuum tube that is resistant to negative pressure, which are connected in series, and the vacuum tube is further connected to the box body 31. The vacuum system 4 may further include a two-way valve, and the vacuum pump is an oil pump or a water pump, preferably a water pump, and may be independent from the housing 5 of the present invention, or may be installed inside the housing 5, and is communicated with the sterilization box 3 through a vacuum tube and the two-way valve (vacuum valve).

Preferably, the detection system 7 includes a sensing device, a signal processing device and a display device, which are connected in sequence, and the sensing device is connected with the box body 31. Wherein, adopt in detecting system 7 to detect special chemical sensor and signal amplifier and digital display of nanometer fog disinfectant, chemical sensor mainly includes the special sensor that can detect nanometer fog disinfectant, and the sensor can be installed in sterilization box 3, also can install on the air-out pipeline of sterilization box 3, still can be connected with the air intake or the air outlet of spraying system 2.

As shown in fig. 1, further, the nano-mist disinfection and sterilization apparatus further includes at least one housing 5, and the liquid storage system 1, the separation and drying system 6, the sterilization box 3, the spraying system 2 and the control system are all disposed inside the housing 5. The vacuum system 4 and the detection system 7 may be arranged inside said housing 5 or outside said housing 5. All the components of the vacuum system 4, the spraying system 2, the separation and drying system 6, the control system, the sterilization box 3, the detection system 7 and the like can be contained in one housing 5, when a plurality of housings 5 are included, the components can be contained in two or three housings 5, for example, the spraying system 2 and the separation and drying system 6 are contained in one housing 5, the vacuum system 4, the sterilization box 3, the control system, the detection system 7 and the like are contained in another housing 5, and the vacuum system 4 can even be independent of the housing 5.

In the embodiment of the invention, during the specific disinfection and sterilization operation, the following steps are carried out in a pulsating mode: the vacuum system 4 firstly pumps out air in the sterilization box body 3, the liquid storage device 11 and the separation drying system 6 to form vacuum, then the spraying system 2 is started to spray the disinfectant in the liquid storage system 1 to small particles (wet particles) with the particle size of less than 10 microns, the small particles are injected into the separation drying system 6 to be separated and dried to form a dried nano-mist disinfectant, the nano-mist disinfectant is injected into the sterilization box body 3 through a pipeline and a nano-mist injection inlet in the sterilization box body 3, and then the nano-mist disinfectant returns to the spraying system 2 from a nano-mist discharge outlet in the sterilization box body 3 to be circulated; when the vacuum degree in the sterilization box body 3 reaches the normal pressure (the vacuum degree is zero), the spraying system 2 is closed, the vacuum system 4 is started, the sterilization box body 3 is vacuumized again, the spraying system 2 is started again to spray the disinfectant into small particles, the small particles are injected into the separation drying system 6 to be separated and dried to form dry nano mist, the dry nano mist is injected into the sterilization box body 3 through a pipeline, and the nano mist is returned into the spraying system 2 from a nano mist outlet in the sterilization box body 3 to be circulated; that is, the generated nano-mist disinfectant is injected into the sterilization box 3 in a pulsating manner in several times, including simultaneously injecting into various pipes or containers placed in the sterilization box 3. When the vacuum degree in the sterilizing box body 3 reaches zero again, the fan 21 of the spraying system 2 is closed, and the sterilizing box body 3 is exposed in the nano mist of the disinfectant for sterilization;

after the preset exposure disinfection and sterilization time is reached, firstly, a control valve can be flexibly arranged according to actual requirements through a two-way valve (each outlet and each inlet on the disinfection box body 3 in the embodiment of the invention, a two-way valve is generally adopted) to close a nano mist injection port and a nano mist discharge port in the disinfection box body 3, then a vacuum system 4 is started to vacuumize the inside of the disinfection box body 3, namely, a nano mist disinfectant in the disinfection box body 3 is discharged in a vacuumizing mode, and when the required vacuum degree is reached, the vacuum system 4 is closed, a breathing filter 33 on the disinfection box body 3 is opened, and fresh air outside is sucked into the disinfection box body 3; when the vacuum degree in the sterilization box body 3 reaches zero, closing the two-way valve corresponding to the breathing filter 33, starting the vacuum system 4, and discharging the residual nano-mist disinfectant in the sterilization box body 3;

namely, the nano mist disinfectant is injected into the sterilization box body 3 in a pulsating mode to sterilize the sterilization box body 3 and objects in the box body, and then the residual disinfectant in the sterilization box body 3 is discharged in a pulsating mode in a plurality of times until the residual disinfectant in the sterilization box body 3 and the residual disinfectant in a sterilization container are finally reduced to below 1 ppm. The low-temperature pulse sterilization equipment not only can sterilize and disinfect small-sized sealable boxes such as freeze dryers, but also can sterilize and disinfect objects which are difficult to sterilize and are placed in the boxes such as various small-sized pipelines (such as various medical specula) and small-sized containers (such as eye drops).

In the embodiment of the invention, the practical analysis is carried out by adopting an experimental mode, the sterilization box body 3 is a vacuum box, and the sterilization effect of the low-temperature pulse sterilization equipment on the vacuum box and the eye drops in the vacuum box is measured by taking the vacuum box and the eye drops in the vacuum box as an example, and the specific method comprises the following steps:

1. main experimental materials

Biological indicators (Bacillus stearothermophilus spores, spore amount 106 CFU/piece, special culture solution containing same batch number biological indicator) and TSA, 5%

The active hydrogen peroxide is used as special sporicide.

2. Experimental vacuum drying oven

The length, width and height of the interior of the vacuum drying box body are respectively 1.0m multiplied by 0.8m multiplied by 1.4m, and the volume is 1.12m³。

Before the test, a vacuum drying oven is modified into a low-temperature pulse sterilization box body 3 according to the attached drawings of the embodiment: 2 small holes are formed in the top of the vacuum drying box and are respectively used as a disinfectant concentration detection port and a nano mist injection port, the two-way valve communicated with the detection system 7 and the two-way valve communicated with the nano mist injection port are connected, the two-way valve communicated with the detection system 7 is connected with a hydrogen peroxide concentration detector, and the two-way valve communicated with the nano mist injection port is connected with an outlet of the spraying system 2 through a pipeline; 2 small holes are also formed in the bottom of the vacuum drying box and are respectively used as a fresh air inlet and a nano mist outlet, a two-way valve communicated with the breathing filter 33 and a two-way valve communicated with an air inlet of the fan 21 are connected, the two-way valve communicated with the breathing filter 33 is connected with the breathing filter 33, and the two-way valve communicated with the air inlet of the fan 21 is connected with the air inlet of the fan 21 through a pipeline; the vacuum outlet of the original box body is connected with a vacuum pump through a two-way valve communicated with the vacuum system 4; through the modification and connection mode, the spraying system 2, the separation drying system 6 and the sterilization box body 3 form a sterilization system capable of performing pulse circulation under the vacuum condition.

3. Flow of use

(1) 5 percent of disinfectant is added into a disinfectant injection port through a funnel

The active hydrogen peroxide-specific sporicide is added to the reservoir 11 of the apparatus.

(2) 6 biological indicators and eye drops bottles to be sterilized are respectively placed at different positions (upper, middle and lower) on a support 32 in the vacuum box, and 1 biological indicator is randomly placed in each of the 6 eye drops bottles.

(3) Closing the box door and all the two-way valves, sealing all the connecting pipelines, starting the vacuum pump and the two-way valve communicated with the vacuum system 4, pumping the vacuum degree in the vacuum box to-90 kPa, and then closing the vacuum pump and the two-way valve.

(4) And opening a two-way valve communicated with the nano mist injection inlet and a two-way valve communicated with an air inlet of the fan 21, starting the spraying system 2 to atomize the disinfectant, and closing the spraying system 2 and the two-way valves after the vacuum degree in the vacuum box reaches zero and then continuing to atomize for 1-5 min.

(5) Then the vacuum pump and the two-way valve communicated with the vacuum system 4 are started, the vacuum in the vacuum box is pumped to-90 kPa, and then the vacuum pump and the two-way valve are closed.

(6) And opening a two-way valve communicated with the nano mist injection inlet and a two-way valve communicated with an air inlet of the fan 21, starting the spraying system 2 to atomize the disinfectant, and closing the spraying system 2 and the two-way valves after the vacuum degree in the vacuum box reaches zero and then continuously atomizing for 1-5 min.

(7) And (5) repeating the operation (5) and the operation (6) for 1-2 times, opening a two-way valve communicated with the detection system 7 to detect the sterilization concentration of the hydrogen peroxide in the two-way valve, and then closing the two-way valve.

(8) Sealing, exposing, sterilizing for 90-120 min.

(9) And starting the vacuum pump and the two-way valve, pumping the vacuum degree in the sterilization box body 3 to-90 kPa, closing the two-way valve communicated with the vacuum system 4, opening the two-way valve communicated with the breathing filter 33, communicating with the breathing filter 33, sucking fresh air into the sterilization box body 3, and closing the two-way valve communicated with the breathing filter 33 after the vacuum degree reaches zero.

(10) Keeping the two-way valve communicated with the nano mist injection inlet and the two-way valve communicated with the air inlet of the fan 21 in a closed state, opening the two-way valve communicated with the vacuum system 4, starting the vacuum pump, pumping the vacuum degree in the vacuum box to-90 kPa, closing the two-way valve, opening the two-way valve communicated with the breathing filter 33 and communicated with the breathing filter 33, sucking fresh air into the sterilization box body 3, and closing the two-way valve after the vacuum degree reaches zero.

(11) And (5) repeating the operations (9) and (10) for 1-2 times, opening the two-way valve communicated with the detection system 7, detecting that the residual concentration of the hydrogen peroxide in the two-way valve is below 1ppm, and then closing the two-way valve.

(12) The biological indicator (spore strip) is taken out according to a sterile method, put into the thermophilic fat spore culture solution with the corresponding number, placed in a constant temperature incubator according to the instruction of the purchased biological indicator, and observed after being cultured for 24 hours at the temperature of 56 +/-1 ℃. Meanwhile, 1 tablet of the same batch of biological indicators is taken as a positive control. After 24 hours of culture, if the culture solution turns turbid and the color changes from purple to yellow, the culture solution is judged to be positive; if the culture solution is clear and the color does not change, the culture solution is negative; continuing culturing until 7 days, and if the culture solution turns yellow, judging that the sterilization is unqualified; if the culture medium is purple, the culture medium is judged to be qualified for sterilization.

4. Results of the experiment

The results are shown in Table 1. As can be seen from Table 1, when the concentration of the active hydrogen peroxide disinfectant is 6%, the pulsation frequency is 3 times, and the sealing time is 90 minutes, the vacuum box and the eye drop bottle in the box can be sterilized (the number of spores is reduced by six pairs), and the residue of the disinfectant is less than 1ppm, so that the safety range is reached.

TABLE 1 detection results of biological indicator for sterilization of vacuum chamber and eye drop bottle therein

In summary, the invention has the following advantages:

1. because the boiling point of the solution is reduced under the vacuum condition, the disinfectant is easier to volatilize, so that the disinfectant is sprayed under the vacuum condition, and is easier to separate and dry than under the normal pressure condition, thereby greatly improving the atomization effect and the drying efficiency, and the atomized particles are smaller and even reach the nanometer level. The smaller the atomized particles are, the longer the time for suspending in the air is, and the more chance the atomized particles can be fully contacted with bacteria in the air to achieve the aim of sterilization.

2. Because the nano mist disinfectant formed after spraying is injected into the sterilization box body 3 in a pulse spraying mode, the concentration of the nano mist disinfectant in the sterilization box body 3 is improved, and the nano mist disinfectant is very easily injected into various small pipelines (such as various medical endoscopes, disposable syringes and the like) and small containers (such as eye drops), so the low-temperature pulse sterilization mode is particularly suitable for sterilization and disinfection of various small sealable spaces (such as freeze dryers) and various objects (such as plastic catheters and plastic containers) which are not high in temperature and are placed in the sterilization box body 3.

3. Because the residual disinfectant in the sterilization box body 3 is removed by adopting a vacuum pulsation mode, the manufacturing cost and the using cost of the equipment are reduced, the residual disinfectant is completely removed, and the time of the disinfection operation is saved.

4. Unlike the Vaporized hydrogen peroxide sterilization technology (VHP), VHP requires the use of a high-concentration hydrogen peroxide solution (greater than 30% or more), is not only highly corrosive, but also gradually increases in viscosity with increasing concentration of hydrogen peroxide, and is also not easily diffused in the air. The technology only needs hydrogen peroxide solution with the concentration of less than 5 percent, does not need high temperature condition, and is safer to use.

5. The invention is provided with a detection system 7, which can monitor the concentration of the nano mist of the disinfectant at any time and can also detect the concentration of the residual nano mist of the disinfectant after elimination.

6. The invention is used in cooperation with an active hydrogen peroxide disinfectant, has the advantages of no residue and no pollution after sterilization, and is green and environment-friendly sterilization equipment.

Although the present application has been described with reference to a preferred embodiment, it should be understood that various changes and modifications can be made without departing from the spirit and scope of the invention as defined by the appended claims.

Claims

1. A pulse sterilizing apparatus, characterized in that it comprises: a liquid storage system, a separation drying system, a detection system, a spraying system, a vacuum system, a sterilization box body and a control system, wherein the separation drying system is positioned above the liquid storage system, the separation drying system is connected with the liquid storage system, the liquid storage system is used for storing disinfectant, the separation drying system is sequentially connected with the sterilization box body and the spraying system, the spraying system is also respectively connected with the separation drying system and the liquid storage system, the sterilization box body is also respectively connected with the detection system and the vacuum system, the control system is connected with the spraying system, the vacuum system and the detection system, the spraying system sprays the disinfectant into small particles, the small particles are injected into a separation and drying system for separation and drying to form dry nano mist, and the dry nano mist is injected into a sterilization box body for sterilization;

the nano-mist disinfectant is injected into the sterilization box body in a pulsating mode in a divided mode.

2. The pulsation sterilization equipment according to claim 1, wherein the liquid storage system comprises a liquid storage device and a liquid conveying pipe, the disinfectant is stored in the liquid storage device, the top of the liquid storage device is connected with the separation and drying system, the bottom of the liquid storage device is provided with a liquid discharging hole, one end of the liquid conveying pipe is connected with the liquid discharging hole, and the other end of the liquid conveying pipe is connected with the spraying system.

3. A pulse sterilization apparatus according to claim 2, wherein the spraying system comprises a fan, a venturi tube and a spray head, the sterilization box body is connected with the fan, the venturi tube, the spray head and the separation drying system in sequence, and the venturi tube is further connected with the infusion tube.

4. A pulse sterilisation apparatus according to claim 3, wherein said separation and drying system internally comprises at least one cavity, said cavity side being connected to said spray head and said cavity bottom being connected to said reservoir.

5. A pulse sterilization device according to claim 4, wherein the separation and drying system comprises a first cavity, a second cavity and a third cavity which are connected in sequence, the bottom of the first cavity is connected with the liquid storage device, the side part of the first cavity is connected with the atomizing spray head, the third cavity is further connected with the sterilization box body, the top of the third cavity is provided with an opening, a sealing cover is arranged on the opening, and the bottom of the third cavity is connected with the first cavity or the liquid storage device.

6. A pulse sterilization apparatus according to any one of claims 1-5, wherein the sterilization box body comprises a box body and a support, a plurality of supports are arranged inside the box body, and objects to be sterilized are placed on the supports.

7. A pulse sterilization apparatus according to claim 6, wherein the sterilization chamber further comprises a respiratory filter and a vacuum gauge, the respiratory filter is located outside the chamber body, and the respiratory filter and the vacuum gauge are both connected to the chamber body.

8. A pulse sterilization device according to claim 7, wherein the vacuum system comprises a vacuum pump and a vacuum tube with negative pressure resistance which are connected in sequence, and the vacuum tube is also connected with the box body.

9. A pulse sterilization device according to claim 8, wherein the detection system comprises a sensing device, a signal processing device and a display device which are connected in sequence, the sensing device is connected with the box body, and the sensing device is further connected with a spraying system.

10. A pulse sterilisation apparatus according to claim 9, further comprising at least one housing, the reservoir system, the separation and drying system, the sterilisation tank, the spray system and the control system all being disposed within the housing.