CN110038155A - 一种促进创伤愈合的医用凝胶 - Google Patents

一种促进创伤愈合的医用凝胶 Download PDF

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CN110038155A
CN110038155A CN201910287503.4A CN201910287503A CN110038155A CN 110038155 A CN110038155 A CN 110038155A CN 201910287503 A CN201910287503 A CN 201910287503A CN 110038155 A CN110038155 A CN 110038155A
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吴强
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Shaanxi Ren Hao Medical Instrument Co Ltd
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    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
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Abstract

本发明涉及一种促进创伤愈合的医用凝胶，其重量计组分包括：甲壳素3‑5份、壳聚糖2‑4份、葡聚多糖5‑10份、保温剂4‑6份、增稠剂1‑3份，生物介质6‑12份，其余为无菌蒸馏水；所述生物介质包括alpha‑葡聚糖2‑4份及beta‑葡聚糖2‑4份；所述甲壳素是由乙酰‑氨基‑葡萄糖胺以糖苷键连结而成的含氮多糖；所述甲壳素来源于甲壳动物骨骼或菌类植物细胞膜；所述壳聚糖是甲壳素的脱乙酰化产物；所述葡聚多糖来源于微生物生长过程中分泌的粘液。本发明的优点是，在现有产品、技术上又创新增加了同型多糖，尤其是新型葡聚糖，具有提高白细胞、细胞裂变和特殊抗体含量的功效，不含肉毒素，在治疗肿瘤、感染、创伤，减少瘢痕方面具有很好的成效。

Description

一种促进创伤愈合的医用凝胶
技术领域
本发明属于医用凝胶领域，具体涉及一种促进创伤愈合的医用凝胶。
背景技术
凝胶是指颗粒大小在1埃到10埃之间的混合物。高分子溶液和某些溶胶，在适当的条件下，整个体系会转变成一种弹性的半固体状态的稠厚物质，失去流动性。这种现象称为胶凝作用，所形成的产物叫做凝胶或冻胶。现有医用凝胶止血、愈合伤口的效果不够理想。
壳聚糖作为有机多糖的一大组成成分，具有优异的生物相容性、生物降解性、抗菌活性及止血特性，是一种天然的生物相容性高分子材料，并得到了广泛的认可和应用。作为凝胶，可以大大提高医用凝胶的止血效果、促进伤口快速愈合。本发明以其为主要原料，进行医用凝胶的改进。
发明内容
本发明的目的是解决上述问题，提供一种促进创伤愈合的医用凝胶，具有提高白细胞、细胞裂变和特殊抗体含量的功效，不含肉毒素，在治疗肿瘤、感染、创伤、瘢痕修复方面具有很好的成效。
为实现上述目的，本发明提供如下技术方案：
一种促进创伤愈合的医用凝胶，其重量计组分包括：甲壳素3-5份、壳聚糖2-4份、葡聚多糖5-10份、保温剂4-6份、增稠剂1-3份，生物介质6-12份，其余为无菌蒸馏水。
进一步的，所述生物介质包括alpha-葡聚糖2-4份及beta-葡聚糖2-4份。
进一步的，所述甲壳素是由乙酰-氨基-葡萄糖胺以糖苷键连结而成的含氮多糖。
进一步的，所述甲壳素来源于甲壳动物骨骼或菌类植物细胞膜。
进一步的，所述壳聚糖是甲壳素的脱乙酰化产物。
进一步的，所述葡聚多糖来源于微生物生长过程中分泌的粘液。
本发明的有益效果在于：
本发明为现有技术和产品的提高和创新，在现有产品、技术上又创新增加了同型多糖，尤其是新型葡聚糖，具有提高白细胞、细胞裂变和特殊抗体含量的功效，不含肉毒素，在治疗肿瘤、感染、创伤方面具有很好的成效；同时本发明的医用凝胶在瘢痕的辅助治疗方面也有很好的效果，能够减少新瘢痕，淡化旧瘢痕。
具体实施方式
一种促进创伤愈合的医用凝胶，其重量计组分包括：甲壳素3-5份、壳聚糖2-4份、葡聚多糖5-10份、保温剂4-6份、增稠剂1-3份，生物介质6-12份，其余为无菌蒸馏水。
进一步的，所述生物介质包括alpha-葡聚糖2-4份及beta-葡聚糖2-4份。
进一步的，所述甲壳素是由乙酰-氨基-葡萄糖胺以糖苷键连结而成的含氮多糖。
进一步的，所述甲壳素来源于甲壳动物骨骼或菌类植物细胞膜。
进一步的，所述壳聚糖是甲壳素的脱乙酰化产物。
进一步的，所述葡聚多糖来源于微生物生长过程中分泌的粘液。
甲壳素：又称甲壳多糖、几丁质。甲壳动物(虾、蟹)等的骨骼和菌类(地衣)等的细胞膜的重要成分。白色半透明固体。不溶于水、乙醇和乙醚。是由N-乙酰α-氨基-D-葡萄糖胺以β(1→4)糖苷键连结而成的含氮多糖。溶于浓无机酸和无水甲酸。在浓酸或浓碱中发生水解而成α-氨基葡萄糖。可用于纺织品的防皱和防缩处理；直接染料或硫化染料的固色；涂料印花的固着；木材的胶合以及防雨篷布的上浆等；也可用作制人造纤维和塑料等的原料。由含有甲壳质的物质如虾壳、蟹壳等提取制得。甲壳素广泛存在于蟹、虾等甲壳动物的外壳及各种昆虫的表皮和贝类等软体动物的骨骼、外壳中，以及蘑菇和灵芝等的细胞壁中，是自然界中唯一带正电荷的动物性膳食纤维素。对于人体具有调节免疫功能，有活化细胞、抑制老化、预防疾病、调节人体生理功能等作用。是功能最全面、效果最显著的第三代机能性健康食品。
壳聚糖是甲壳素的脱乙酰化产物，又称可溶甲壳素、壳多糖、甲壳胺，是一种天然生物高分子聚合物，白色结品性扮末，有很强的吸湿性，仅次于甘油，高于聚乙二醇、山梨醇。在吸湿过程中，分子中的羟基、胺基等极性基团与水分子作用而水合，分子链逐渐膨胀，随着pH值的变化，分子够从球状胶束变成线状。具有很好成膜性、透气性和生物相容性，无毒，且可生物降解。
葡聚多糖是指以葡萄糖为单糖组成的同型多糖，葡萄糖单元之间以糖苷键连接。其中根据糖苷键的类型又可分为alpha-葡聚糖和beta-葡聚糖；alpha-葡聚糖中研究及使用较多的为dextran，又称右旋糖酐，为一种多糖，存在于某些微生物在生长过程中分泌的粘液中。葡聚糖具有较高的分子量，水解主要得到异麦芽糖。葡聚糖在输血过程中可代替一部分全血，溶于生理盐水，属低聚糖、多糖，具有提高免疫力、提高白细胞、细胞分裂素和特殊抗体含量的功效，在治疗肿瘤、感染、创伤、瘢痕方面深受瞩目，不含肉毒素，广泛存在于多种真菌和植物、香菇、灵芝、燕麦中，能够改善血脂、抗辐射、改善肠道功能。
本发明为现有技术和产品的提高和创新，在现有产品、技术上又创新增加了同型多糖，尤其是新型葡聚糖，具有提高白细胞、细胞裂变和特殊抗体含量的功效，不含肉毒素，在治疗肿瘤、感染、创伤方面具有很好的成效；同时本发明的医用凝胶在瘢痕的辅助治疗方面也有很好的效果，能够减少新瘢痕，淡化旧瘢痕。
本发明中未做详细描述的内容均为现有技术。
以上所述仅为本发明的较佳实施例而已，并不用以限制本发明，凡在本发明的精神和原则之内，所作的任何修改、等同替换、改进等，均应包含在本发明的保护范围之内。

Claims (6)

1.一种促进创伤愈合的医用凝胶，其特征在于，其重量计组分包括：甲壳素3-5份、壳聚糖2-4份、葡聚多糖5-10份、保温剂4-6份、增稠剂1-3份，生物介质6-12份，其余为无菌蒸馏水。
2.根据权利要求1所述的一种促进创伤愈合的医用凝胶，其特征在于，所述生物介质包括alpha-葡聚糖2-4份及beta-葡聚糖2-4份。
3.根据权利要求1所述的一种促进创伤愈合的医用凝胶，其特征在于，所述甲壳素是由乙酰-氨基-葡萄糖胺以糖苷键连结而成的含氮多糖。
4.根据权利要求1或3所述的一种促进创伤愈合的医用凝胶，其特征在于，所述甲壳素来源于甲壳动物骨骼或菌类植物细胞膜。
5.根据权利要求1所述的一种促进创伤愈合的医用凝胶，其特征在于，所述壳聚糖是甲壳素的脱乙酰化产物。
6.根据权利要求1所述的一种促进创伤愈合的医用凝胶，其特征在于，所述葡聚多糖来源于微生物生长过程中分泌的粘液。
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Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102600494A (zh) * 2012-03-30 2012-07-25 武汉华纳联合药业有限公司 一种多糖组合物及其制备方法和用途
KR20140108803A (ko) * 2013-02-28 2014-09-15 아이큐어 주식회사 시트리스 하이드로겔 필름 및 그 이의 제조 방법
CN104874009A (zh) * 2015-05-22 2015-09-02 苏州市贝克生物科技有限公司 一种医用抗菌凝胶材料的制备方法
CN106075556A (zh) * 2016-06-02 2016-11-09 四川奎星医用高分子制品有限责任公司 含有促进伤口愈合药物的医用复合壳聚糖凝胶
CA2989147A1 (en) * 2015-06-11 2016-12-15 Medtronic Xomed, Inc. Useful polysaccharide after radiation sterilization
CN107550753A (zh) * 2017-10-17 2018-01-09 广州润虹医药科技股份有限公司 一种具有皮肤修复、抗衰老功能的组合物及其制备方法

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102600494A (zh) * 2012-03-30 2012-07-25 武汉华纳联合药业有限公司 一种多糖组合物及其制备方法和用途
KR20140108803A (ko) * 2013-02-28 2014-09-15 아이큐어 주식회사 시트리스 하이드로겔 필름 및 그 이의 제조 방법
CN104874009A (zh) * 2015-05-22 2015-09-02 苏州市贝克生物科技有限公司 一种医用抗菌凝胶材料的制备方法
CA2989147A1 (en) * 2015-06-11 2016-12-15 Medtronic Xomed, Inc. Useful polysaccharide after radiation sterilization
CN106075556A (zh) * 2016-06-02 2016-11-09 四川奎星医用高分子制品有限责任公司 含有促进伤口愈合药物的医用复合壳聚糖凝胶
CN107550753A (zh) * 2017-10-17 2018-01-09 广州润虹医药科技股份有限公司 一种具有皮肤修复、抗衰老功能的组合物及其制备方法

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