CN110037258A - A kind of anti-sea-buckthorn compound superfine powder and its preparation method for being mutated, pressing down cancer and cancer cell specific induction of apoptosis - Google Patents
A kind of anti-sea-buckthorn compound superfine powder and its preparation method for being mutated, pressing down cancer and cancer cell specific induction of apoptosis Download PDFInfo
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- CN110037258A CN110037258A CN201910298295.8A CN201910298295A CN110037258A CN 110037258 A CN110037258 A CN 110037258A CN 201910298295 A CN201910298295 A CN 201910298295A CN 110037258 A CN110037258 A CN 110037258A
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- 239000000843 powder Substances 0.000 title claims abstract description 82
- 206010028980 Neoplasm Diseases 0.000 title claims abstract description 51
- 201000011510 cancer Diseases 0.000 title claims abstract description 51
- 150000001875 compounds Chemical class 0.000 title claims abstract description 38
- 238000002360 preparation method Methods 0.000 title claims abstract description 29
- 230000006882 induction of apoptosis Effects 0.000 title claims abstract description 18
- 238000003825 pressing Methods 0.000 title description 2
- 239000000284 extract Substances 0.000 claims abstract description 107
- 241000229143 Hippophae Species 0.000 claims abstract description 86
- 235000003145 Hippophae rhamnoides Nutrition 0.000 claims abstract description 86
- WCGUUGGRBIKTOS-GPOJBZKASA-N (3beta)-3-hydroxyurs-12-en-28-oic acid Chemical compound C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CC[C@@H](C)[C@H](C)[C@H]5C4=CC[C@@H]3[C@]21C WCGUUGGRBIKTOS-GPOJBZKASA-N 0.000 claims abstract description 49
- 229940096998 ursolic acid Drugs 0.000 claims abstract description 49
- PLSAJKYPRJGMHO-UHFFFAOYSA-N ursolic acid Natural products CC1CCC2(CCC3(C)C(C=CC4C5(C)CCC(O)C(C)(C)C5CCC34C)C2C1C)C(=O)O PLSAJKYPRJGMHO-UHFFFAOYSA-N 0.000 claims abstract description 49
- CWEZAWNPTYBADX-UHFFFAOYSA-N Procyanidin Natural products OC1C(OC2C(O)C(Oc3c2c(O)cc(O)c3C4C(O)C(Oc5cc(O)cc(O)c45)c6ccc(O)c(O)c6)c7ccc(O)c(O)c7)c8c(O)cc(O)cc8OC1c9ccc(O)c(O)c9 CWEZAWNPTYBADX-UHFFFAOYSA-N 0.000 claims abstract description 27
- 229920002414 procyanidin Polymers 0.000 claims abstract description 27
- 235000013399 edible fruits Nutrition 0.000 claims abstract description 26
- XFZJEEAOWLFHDH-UHFFFAOYSA-N (2R,2'R,3R,3'R,4R)-3,3',4',5,7-Pentahydroxyflavan(48)-3,3',4',5,7-pentahydroxyflavan Natural products C=12OC(C=3C=C(O)C(O)=CC=3)C(O)CC2=C(O)C=C(O)C=1C(C1=C(O)C=C(O)C=C1O1)C(O)C1C1=CC=C(O)C(O)=C1 XFZJEEAOWLFHDH-UHFFFAOYSA-N 0.000 claims abstract description 23
- MOJZMWJRUKIQGL-FWCKPOPSSA-N Procyanidin C2 Natural products O[C@@H]1[C@@H](c2cc(O)c(O)cc2)Oc2c([C@H]3[C@H](O)[C@@H](c4cc(O)c(O)cc4)Oc4c3c(O)cc(O)c4)c(O)cc(O)c2[C@@H]1c1c(O)cc(O)c2c1O[C@@H]([C@H](O)C2)c1cc(O)c(O)cc1 MOJZMWJRUKIQGL-FWCKPOPSSA-N 0.000 claims abstract description 23
- HGVVOUNEGQIPMS-UHFFFAOYSA-N procyanidin Chemical compound O1C2=CC(O)=CC(O)=C2C(O)C(O)C1(C=1C=C(O)C(O)=CC=1)OC1CC2=C(O)C=C(O)C=C2OC1C1=CC=C(O)C(O)=C1 HGVVOUNEGQIPMS-UHFFFAOYSA-N 0.000 claims abstract description 23
- 150000003648 triterpenes Chemical class 0.000 claims abstract description 23
- 241001545416 Ilex kaushue Species 0.000 claims abstract description 22
- 230000001629 suppression Effects 0.000 claims abstract description 16
- 230000002019 anti-mutation Effects 0.000 claims abstract description 11
- 239000002994 raw material Substances 0.000 claims abstract description 11
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 78
- 235000019441 ethanol Nutrition 0.000 claims description 40
- 239000012141 concentrate Substances 0.000 claims description 36
- 238000000605 extraction Methods 0.000 claims description 29
- 238000001914 filtration Methods 0.000 claims description 26
- 238000007906 compression Methods 0.000 claims description 18
- 238000001035 drying Methods 0.000 claims description 18
- 238000001704 evaporation Methods 0.000 claims description 18
- 230000008020 evaporation Effects 0.000 claims description 18
- 239000007787 solid Substances 0.000 claims description 18
- 239000002893 slag Substances 0.000 claims description 16
- 239000007788 liquid Substances 0.000 claims description 8
- 238000011049 filling Methods 0.000 claims description 4
- 235000015112 vegetable and seed oil Nutrition 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 3
- 239000004576 sand Substances 0.000 claims description 3
- 235000007297 Gaultheria procumbens Nutrition 0.000 claims description 2
- 241000629412 Ligustrum robustum Species 0.000 claims description 2
- 241000333569 Pyrola minor Species 0.000 claims description 2
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 claims description 2
- 238000002156 mixing Methods 0.000 claims description 2
- 230000035772 mutation Effects 0.000 claims 5
- 230000000694 effects Effects 0.000 abstract description 3
- 239000004480 active ingredient Substances 0.000 abstract description 2
- 238000013329 compounding Methods 0.000 abstract description 2
- 239000000126 substance Substances 0.000 abstract description 2
- 230000002195 synergetic effect Effects 0.000 abstract description 2
- 230000000259 anti-tumor effect Effects 0.000 abstract 2
- 230000003078 antioxidant effect Effects 0.000 abstract 2
- 239000003963 antioxidant agent Substances 0.000 abstract 1
- 235000006708 antioxidants Nutrition 0.000 abstract 1
- 230000004071 biological effect Effects 0.000 abstract 1
- 230000000711 cancerogenic effect Effects 0.000 abstract 1
- 231100000315 carcinogenic Toxicity 0.000 abstract 1
- 230000003013 cytotoxicity Effects 0.000 abstract 1
- 231100000135 cytotoxicity Toxicity 0.000 abstract 1
- 150000003254 radicals Chemical class 0.000 abstract 1
- 239000000047 product Substances 0.000 description 7
- 239000000706 filtrate Substances 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 241000209035 Ilex Species 0.000 description 2
- 235000003325 Ilex Nutrition 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 208000009458 Carcinoma in Situ Diseases 0.000 description 1
- 208000017667 Chronic Disease Diseases 0.000 description 1
- 206010064571 Gene mutation Diseases 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000000378 dietary effect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000004134 energy conservation Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 235000013376 functional food Nutrition 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 201000004933 in situ carcinoma Diseases 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L19/00—Products from fruits or vegetables; Preparation or treatment thereof
- A23L19/01—Instant products; Powders; Flakes; Granules
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L19/00—Products from fruits or vegetables; Preparation or treatment thereof
- A23L19/09—Mashed or comminuted products, e.g. pulp, purée, sauce, or products made therefrom, e.g. snacks
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Abstract
The invention discloses the sea-buckthorn compound superfine powders and its preparation method of a kind of anti-mutation, suppression cancer and cancer cell specific induction of apoptosis, the raw material for preparing the sea-buckthorn compound superfine powder includes seabuckthorn seeds procyanidin extract, seabuckthorn fruit peel ursolic acid extract, Ilex kudingcha C.J.Tseng old leaf ursolic acid extract and fuling peel triterpene extract, wherein main active of the seabuckthorn seeds procyanidin extract as the sea-buckthorn compound superfine powder, with extremely strong antioxidant activity, free radical can be effectively removed；Ursolic acid have extensive biological effect, it is outstanding effect be it is antitumor, to it is a variety of it is carcinogenic, promote cancer objects have resistant function, have obvious cytotoxicity to a variety of cancer cells；Fuling peel triterpene extract has obvious anti-oxidant, anti-tumor activity；By the compounding of several substances, active ingredient group is formed, common synergistic effect plays the role of more effectively anti-mutation, suppression cancer and cancer cell specific induction of apoptosis.
Description
Technical field
The invention belongs to field of functional food, in particular to the sand of a kind of anti-mutation, suppression cancer and cancer cell specific induction of apoptosis
Spine compound superfine powder and its preparation method.
Background technique
Cancer is to endanger the most important chronic disease of national health, has the spy of high sick hair rate, high mortality, low survival rate
Point.As soon as average minute clock has 8 people to be diagnosed as cancer, has 5 currently, the whole nation is diagnosed as cancer more than ten thousand people daily
Individual is dead because of cancer.The cancer neopathy case in the whole nation accounts for 4 one-tenth of the whole world.Crowd's cancer morbidity quickly increases within 30 years old or more
Height, into the cancer high-incidence season, disease incidence fast lifting after 40 years old peaks for 80 years old.Nearly ten years, cancer morbidity is annual
Increase about 4%, it is contemplated that arrive the year two thousand twenty, the year morbidity sum of cancer is up to 6,000,000 people or more, and annual cancer mortality sum also will
Up to more than 3,000,000 people.
Gene mutation, immunologic escape are that most crucial factor occurs for cancer.Cancer develops into carcinoma in situ from normal cell and needs
Take 10 ~ 30 years.Studies have shown that precancerous lesion is usually irreversible, therefore, capturing cancer should be since prevention.For this purpose, seeking
It looks for safety and dietary product, health care product or the drug occurred with pre- anti-cancer is a urgent problem to be solved.
Summary of the invention
To solve the above problems, the object of the present invention is to provide the sand of a kind of anti-mutation, suppression cancer and cancer cell specific induction of apoptosis
Spine compound superfine powder and its preparation method.By the compounding of several substances, active ingredient group is formed, common synergistic effect plays more
The effect of effective anti-mutation, suppression cancer and cancer cell specific induction of apoptosis.
The purpose of the present invention is what is be achieved through the following technical solutions:
A kind of anti-sea-buckthorn compound superfine powder for being mutated, pressing down cancer and cancer cell specific induction of apoptosis, prepares the sea-buckthorn compound Ultramicro-powder
The raw material of agent includes that seabuckthorn seeds procyanidin extract, seabuckthorn fruit peel ursolic acid extract, Ilex kudingcha C.J.Tseng old leaf ursolic acid mention
Take object and fuling peel triterpene extract, the weight fraction ratio of each raw material are as follows:
Seabuckthorn seeds procyanidin extract 5 ~ 20
Seabuckthorn fruit peel ursolic acid extract 30 ~ 45
Ilex kudingcha C.J.Tseng old leaf ursolic acid extract 20 ~ 40
Fuling peel triterpene extract 20 ~ 40.
Further, the seabuckthorn seeds procyanidin extract the preparation method comprises the following steps:
Through supercritical CO2Sea-buckthorn seed cake after extracting Seabuckthorm Seed Oil is impregnated at least 1 hour with 6 ~ 15 times of 40% ~ 80% ethyl alcohol,
0.2h ~ 0.5h is extracted using homogenate extraction method under 15 DEG C ~ 35 DEG C normal temperature conditions, extracting solution is collected by filtration, slag is extracted and repeats to extract 2
~ 3 times, obtained extracting solution is repeatedly extracted in merging, then uses low-temperature negative-pressure closed loop thermo-compression evaporation enrichment facility, recycles ethyl alcohol,
And concentrated extracting solution is greater than 45% concentrate to soluble solid, concentrate is dry using low-temperature negative-pressure belt drying unit,
Obtain seabuckthorn seeds procyanidin extract coarse powder.
Further, the seabuckthorn fruit peel ursolic acid extract the preparation method comprises the following steps:
Seabuckthorn fruit peel is impregnated at least 1 hour with 6 ~ 15 times of 60% ~ 85% ethyl alcohol, using flash under 15 DEG C ~ 35 DEG C normal temperature conditions
Extraction method extracts 0.2h ~ 0.5h, and extracting solution is collected by filtration, and extracts slag and repeats to extract 2 ~ 3 times, obtained extraction is repeatedly extracted in merging
Liquid, then low-temperature negative-pressure closed loop thermo-compression evaporation enrichment facility is used, ethyl alcohol is recycled, and concentrated extracting solution is big to soluble solid
In 40% concentrate, concentrate is dry using low-temperature negative-pressure belt drying unit, and it is thick to obtain seabuckthorn fruit peel ursolic acid extract
Powder.
Further, the Ilex kudingcha C.J.Tseng old leaf ursolic acid extract the preparation method comprises the following steps:
Ilex kudingcha C.J.Tseng old leaf is crushed to 10 ~ 20 mesh, is impregnated at least 1 hour with 6 ~ 15 times of 60% ~ 85% ethyl alcohol, 15 DEG C ~
0.2h ~ 0.5h is extracted using homogenate extraction method under 35 DEG C of normal temperature conditions, extracting solution is collected by filtration, slag is extracted and repeats to extract 2 ~ 3 times,
Obtained extracting solution is repeatedly extracted in merging, then uses low-temperature negative-pressure closed loop thermo-compression evaporation enrichment facility, recycles ethyl alcohol, and be concentrated
Extracting solution is greater than 40% concentrate to soluble solid, and concentrate is dry using low-temperature negative-pressure belt drying unit, obtains the winter
Green old leaves of Kudingcha ursolic acid extract coarse powder.
Further, the fuling peel triterpene extract the preparation method comprises the following steps:
Fuling peel is crushed to 10 ~ 20 mesh, is impregnated at least 1 hour with 6 ~ 15 times of 60% ~ 85% ethyl alcohol, in 15 DEG C ~ 35 DEG C room temperature items
0.2h ~ 0.5h is extracted using homogenate extraction method under part, extracting solution is collected by filtration, slag is extracted and repeats to extract 2 ~ 3 times, merging repeatedly mentions
The extracting solution obtained, then low-temperature negative-pressure closed loop thermo-compression evaporation enrichment facility is used, ethyl alcohol is recycled, and concentrated extracting solution extremely may be used
Dissolubility solid content is greater than 40% concentrate, and concentrate is dry using low-temperature negative-pressure belt drying unit, obtains fuling peel triterpene and mentions
Take object coarse powder.
Further, sea buckthorn procyanidins > 2.2g, ursolic acid > 1.6g in every 100g sea-buckthorn compound superfine powder.
Further, the low-temperature negative-pressure is that temperature is lower than 50 DEG C, and pressure is higher than -0.098MPa.
The preparation method of the sea-buckthorn compound superfine powder, comprising the following steps:
By seabuckthorn seeds procyanidin extract coarse powder, seabuckthorn fruit peel ursolic acid extract coarse powder, Ilex kudingcha C.J.Tseng old leaf ursolic acid
Extract coarse powder and fuling peel triterpene extract coarse powder are proportionally added in three-dimensional mixer and are uniformly mixed, then will mixing
After uniform coarse powder is crushed to the Ultramicro-powder of 500 mesh or more using airslide disintegrating mill, the filling sea-buckthorn compound ultra micro at every bag of 6g
Powder product.
The present invention having the beneficial effect that compared with prior art
1, the raw material of sea-buckthorn compound superfine powder of the present invention, belongs to the kind of dual-purpose of drug and food, has no toxic side effect, it is ensured that
The safety of product, can take for a long time；
2, the preparation method of sea-buckthorn compound superfine powder of the present invention, using the technology of room temperature homogenate extraction, low temperature (50 DEG C with
Under), negative pressure (- 0.098MPa or more) closed loop thermo-compression evaporation concentration technique, low temperature (50 DEG C or less), negative pressure (- 0.098MPa with
On) belt drying technology, temperature is low, the time is short, has not only been effectively maintained the bioactivity of product, but also energy conservation and environmental protection, greatly
Production cost is reduced greatly.
Specific embodiment
Embodiment 1
The sea-buckthorn compound superfine powder of a kind of anti-mutation, suppression cancer and cancer cell specific induction of apoptosis is present embodiments provided, described in preparation
The raw material of sea-buckthorn compound superfine powder includes seabuckthorn seeds procyanidin extract, seabuckthorn fruit peel ursolic acid extract, Chinese ilex bitter leaves
Tea old leaf ursolic acid extract and fuling peel triterpene extract, the weight of each raw material are as follows:
Seabuckthorn seeds procyanidin extract 6kg
Seabuckthorn fruit peel ursolic acid extract 40kg
Ilex kudingcha C.J.Tseng old leaf ursolic acid extract 38kg
Fuling peel triterpene extract 36kg.
The seabuckthorn seeds procyanidin extract the preparation method comprises the following steps:
Through supercritical CO2Sea-buckthorn seed cake 60kg after extracting Seabuckthorm Seed Oil is impregnated at least 1 hour with 10 times of 60% ethyl alcohol, 15
DEG C ~ 35 DEG C of normal temperature conditions under using homogenate extraction method extract 0.3h, 300 mesh are collected by filtration extracting solution, extract slag and 6 times are added again
60% ethyl alcohol, extract 0.3h using homogenate extraction method under 15 DEG C again ~ 35 DEG C normal temperature conditions, the filtering of 300 mesh is collected again extracts
Liquid, merges the extracting solution extracted twice, and extracting solution uses 45 DEG C of negative pressure (- 0.098MPa or more) closed loop thermo-compression evaporations again
Enrichment facility recycles ethyl alcohol, and concentrated extracting solution is greater than 40% concentrate to soluble solid, and concentrate is negative using low temperature
Press belt type dryer group is dry, obtains seabuckthorn seeds procyanidin extract coarse powder 6kg.
The seabuckthorn fruit peel ursolic acid extract the preparation method comprises the following steps:
12 times of 85% ethyl alcohol of 208kg seabuckthorn fruit peel is impregnated at least 1 hour, using flash under 15 DEG C ~ 35 DEG C normal temperature conditions
Extraction method extracts 0.3h, and extracting solution is collected by filtration in 300 mesh, extracts 85% ethyl alcohol that slag is added 6 times again, 15 DEG C again ~ 35 DEG C often
0.3h is extracted using homogenate extraction method under the conditions of temperature, the filtering of 300 mesh collects extracting solution again, merges the extraction extracted twice
Liquid, then 45 DEG C of negative pressure (- 0.098MPa or more) closed loop thermo-compression evaporation enrichment facilities are used, recycle ethyl alcohol, and concentrated extracting solution
It is greater than 40% concentrate A to soluble solid；Filter residue after extracting twice, is added 15 times of pure water, and 90 DEG C or more slightly boiled to mention
After taking 1.5h, filtrate is obtained by filtration in 300 mesh, and 60 DEG C of negative pressure (- 0.098MPa or more) of the filtrate are concentrated through closed loop thermo-compression evaporation
Device is concentrated into the concentrate B that soluble solids are greater than 40%, merges concentrate A and concentrate B, then below low using 50 DEG C
Warm negative pressure (- 0.098MPa or more) belt drying unit is dry, obtains seabuckthorn fruit peel ursolic acid extract coarse powder 40kg.
The Ilex kudingcha C.J.Tseng old leaf ursolic acid extract the preparation method comprises the following steps:
240kg Ilex kudingcha C.J.Tseng old leaf is crushed to the coarse powder of 10 ~ 20 mesh, is impregnated at least 1 hour with 12 times of 85% ethyl alcohol,
0.3h is extracted using homogenate extraction method under 15 DEG C ~ 35 DEG C normal temperature conditions, extracting solution is collected by filtration in 300 mesh, extracts slag and 6 are added again
Times 85% ethyl alcohol, extract 0.3h using homogenate extraction method under 15 DEG C again ~ 35 DEG C normal temperature conditions, the filtering of 300 mesh is collected again to be mentioned
Liquid is taken, merges the extracting solution extracted twice, then using 45 DEG C of negative pressure (- 0.098MPa or more) closed loop thermo-compression evaporation concentrations
Device recycles ethyl alcohol, and concentrated extracting solution is greater than 40% concentrate to soluble solid, and concentrate is below using 50 DEG C
Low-temperature negative-pressure (- 0.098MPa or more) belt drying unit is dry, obtains Ilex kudingcha C.J.Tseng old leaf ursolic acid extract coarse powder
38kg。
The fuling peel triterpene extract the preparation method comprises the following steps:
255kg fuling peel is crushed to the coarse powder of 10 ~ 20 mesh, is impregnated at least 1 hour with 10 times of 85% ethyl alcohol, at 15 DEG C ~ 35 DEG C
0.3h is extracted using homogenate extraction method under normal temperature condition, extracting solution is collected by filtration, extracts 85% ethyl alcohol that slag is added 6 times again, then
0.3h is extracted using homogenate extraction method under secondary 15 DEG C ~ 35 DEG C normal temperature conditions, the filtering of 300 mesh is collected extracting solution again, merged twice
Obtained extracting solution is extracted, then uses 45 DEG C of negative pressure (- 0.098MPa or more) closed loop thermo-compression evaporation enrichment facilities, recycles second
Alcohol, and concentrated extracting solution is greater than 40% concentrate to soluble solid, concentrate using 50 DEG C of low-temperature negative-pressures below (-
0.098MPa or more) drying of belt drying unit, obtain fuling peel triterpene extract coarse powder 36kg.
The preparation method of the sea-buckthorn compound superfine powder, comprising the following steps:
By seabuckthorn seeds procyanidin extract coarse powder 6kg, seabuckthorn fruit peel ursolic acid extract coarse powder 40kg, Ilex kudingcha C.J.Tseng old leaf
Ursolic acid extract coarse powder 38kg and fuling peel triterpene extract coarse powder 36kg is added in three-dimensional mixer and is uniformly mixed, then
Uniformly mixed coarse powder is crushed to the Ultramicro-powder 120kg of 500 mesh or more using airslide disintegrating mill, it is filling at described in every bag of 6g
Sea-buckthorn compound superfine powder product, 20000 bags of theoretical yield.
Through detecting, sea buckthorn procyanidins > 2.2g in every 100g sea-buckthorn compound superfine powder；Ursolic acid > 1.6g.
The taking dose and method of the sea-buckthorn compound superfine powder are as follows: 1 bag every time, 2 times a day.
Embodiment 2
The sea-buckthorn compound superfine powder of a kind of anti-mutation, suppression cancer and cancer cell specific induction of apoptosis is present embodiments provided, described in preparation
The raw material of sea-buckthorn compound superfine powder includes seabuckthorn seeds procyanidin extract, seabuckthorn fruit peel ursolic acid extract, Chinese ilex bitter leaves
Tea old leaf ursolic acid extract and fuling peel triterpene extract, the weight of each raw material are as follows:
Seabuckthorn seeds procyanidin extract 15kg
Seabuckthorn fruit peel ursolic acid extract 72kg
Ilex kudingcha C.J.Tseng old leaf ursolic acid extract 47kg
Fuling peel triterpene extract 46kg.
The seabuckthorn seeds procyanidin extract the preparation method comprises the following steps:
Through supercritical CO2Sea-buckthorn seed cake 145kg after extracting Seabuckthorm Seed Oil is impregnated at least 1 hour with 10 times of 60% ethyl alcohol,
0.3h is extracted using homogenate extraction method under 15 DEG C ~ 35 DEG C normal temperature conditions, extracting solution is collected by filtration in 300 mesh, extracts slag and 6 are added again
Times 60% ethyl alcohol, extract 0.3h using homogenate extraction method under 15 DEG C again ~ 35 DEG C normal temperature conditions, the filtering of 300 mesh is collected again to be mentioned
Liquid is taken, the extracting solution extracted twice is merged, extracting solution uses 45 DEG C of negative pressure (- 0.098MPa or more) closed loop heat pumps to steam again
Enrichment facility is sent out, recycles ethyl alcohol, and concentrated extracting solution is greater than 40% concentrate to soluble solid, concentrate uses low temperature
Negative pressure belt drying unit is dry, obtains seabuckthorn seeds procyanidin extract coarse powder 15kg.
The seabuckthorn fruit peel ursolic acid extract the preparation method comprises the following steps:
12 times of 85% ethyl alcohol of 522kg seabuckthorn fruit peel is impregnated at least 1 hour, using flash under 15 DEG C ~ 35 DEG C normal temperature conditions
Extraction method extracts 0.3h, and extracting solution is collected by filtration in 300 mesh, extracts 85% ethyl alcohol that slag is added 6 times again, 15 DEG C again ~ 35 DEG C often
0.3h is extracted using homogenate extraction method under the conditions of temperature, the filtering of 300 mesh collects extracting solution again, merges the extraction extracted twice
Liquid, then 45 DEG C of negative pressure (- 0.098MPa or more) closed loop thermo-compression evaporation enrichment facilities are used, recycle ethyl alcohol, and concentrated extracting solution
It is greater than 40% concentrate A to soluble solid；Filter residue after extracting twice, is added 15 times of pure water, and 90 DEG C or more slightly boiled to mention
After taking 1.5h, filtrate is obtained by filtration in 300 mesh, and 60 DEG C of negative pressure (- 0.098MPa or more) of the filtrate are concentrated through closed loop thermo-compression evaporation
Device is concentrated into the concentrate B that soluble solids are greater than 40%, merges concentrate A and concentrate B, then below low using 50 DEG C
Warm negative pressure (- 0.098MPa or more) belt drying unit is dry, obtains seabuckthorn fruit peel ursolic acid extract coarse powder 72kg.
The Ilex kudingcha C.J.Tseng old leaf ursolic acid extract the preparation method comprises the following steps:
288kg Ilex kudingcha C.J.Tseng old leaf is crushed to the coarse powder of 10 ~ 20 mesh, is impregnated at least 1 hour with 12 times of 85% ethyl alcohol,
0.3h is extracted using homogenate extraction method under 15 DEG C ~ 35 DEG C normal temperature conditions, extracting solution is collected by filtration in 300 mesh, extracts slag and 6 are added again
Times 85% ethyl alcohol, extract 0.3h using homogenate extraction method under 15 DEG C again ~ 35 DEG C normal temperature conditions, the filtering of 300 mesh is collected again to be mentioned
Liquid is taken, merges the extracting solution extracted twice, then using 45 DEG C of negative pressure (- 0.098MPa or more) closed loop thermo-compression evaporation concentrations
Device recycles ethyl alcohol, and concentrated extracting solution is greater than 40% concentrate to soluble solid, and concentrate is below using 50 DEG C
Low-temperature negative-pressure (- 0.098MPa or more) belt drying unit is dry, obtains Ilex kudingcha C.J.Tseng old leaf ursolic acid extract coarse powder
47kg。
The fuling peel triterpene extract the preparation method comprises the following steps:
280kg fuling peel is crushed to the coarse powder of 10 ~ 20 mesh, is impregnated at least 1 hour with 10 times of 85% ethyl alcohol, at 15 DEG C ~ 35 DEG C
0.3h is extracted using homogenate extraction method under normal temperature condition, extracting solution is collected by filtration, extracts 85% ethyl alcohol that slag is added 6 times again, then
0.3h is extracted using homogenate extraction method under secondary 15 DEG C ~ 35 DEG C normal temperature conditions, the filtering of 300 mesh is collected extracting solution again, merged twice
Obtained extracting solution is extracted, then uses 45 DEG C of negative pressure (- 0.098MPa or more) closed loop thermo-compression evaporation enrichment facilities, recycles second
Alcohol, and concentrated extracting solution is greater than 40% concentrate to soluble solid, concentrate using 50 DEG C of low-temperature negative-pressures below (-
0.098MPa or more) drying of belt drying unit, obtain fuling peel triterpene extract coarse powder 46kg.
The preparation method of the sea-buckthorn compound superfine powder, comprising the following steps:
Seabuckthorn seeds procyanidin extract coarse powder 15kg, seabuckthorn fruit peel ursolic acid extract coarse powder 72kg, Ilex kudingcha C.J.Tseng is old
Leaf ursolic acid extract coarse powder 47kg and fuling peel triterpene extract coarse powder 46kg is added in three-dimensional mixer and is uniformly mixed,
Uniformly mixed coarse powder is crushed to the Ultramicro-powder 180kg of 500 mesh or more, the filling institute at every bag of 6g using airslide disintegrating mill again
State sea-buckthorn compound superfine powder product, 30000 bags of theoretical yield.
Through detecting, sea buckthorn procyanidins > 2.2g in every 100g sea-buckthorn compound superfine powder；Ursolic acid > 1.6g.
The taking dose and method of the sea-buckthorn compound superfine powder are as follows: 1 bag every time, 2 times a day.
Claims (9)
1. the sea-buckthorn compound superfine powder of a kind of anti-mutation, suppression cancer and cancer cell specific induction of apoptosis, which is characterized in that prepare the sand
The raw material of spine compound superfine powder includes seabuckthorn seeds procyanidin extract, seabuckthorn fruit peel ursolic acid extract, Ilex kudingcha C.J.Tseng
Old leaf ursolic acid extract and fuling peel triterpene extract, the weight fraction ratio of each raw material are as follows:
Seabuckthorn seeds procyanidin extract 5 ~ 20
Seabuckthorn fruit peel ursolic acid extract 30 ~ 45
Ilex kudingcha C.J.Tseng old leaf ursolic acid extract 20 ~ 40
Fuling peel triterpene extract 20 ~ 40.
2. the sea-buckthorn compound superfine powder of mutation according to claim 1, suppression cancer and cancer cell specific induction of apoptosis, feature exist
In the weight fraction ratio of each raw material are as follows:
Seabuckthorn seeds procyanidin extract 10 ~ 15
Seabuckthorn fruit peel ursolic acid extract 20 ~ 35
Ilex kudingcha C.J.Tseng old leaf ursolic acid extract 10 ~ 30
Fuling peel triterpene extract 10 ~ 30.
3. the sea-buckthorn compound superfine powder of mutation according to claim 1, suppression cancer and cancer cell specific induction of apoptosis, feature exist
In, the seabuckthorn seeds procyanidin extract the preparation method comprises the following steps:
Through supercritical CO2Sea-buckthorn seed cake after extracting Seabuckthorm Seed Oil is impregnated at least 1 hour with 6 ~ 15 times of 40% ~ 80% ethyl alcohol,
0.2h ~ 0.5h is extracted using homogenate extraction method under 15 DEG C ~ 35 DEG C normal temperature conditions, extracting solution is collected by filtration, slag is extracted and repeats to extract 2
~ 3 times, obtained extracting solution is repeatedly extracted in merging, then uses low-temperature negative-pressure closed loop thermo-compression evaporation enrichment facility, recycles ethyl alcohol,
And concentrated extracting solution is greater than 40% concentrate to soluble solid, concentrate is dry using low-temperature negative-pressure belt drying unit,
Obtain seabuckthorn seeds procyanidin extract coarse powder.
4. the sea-buckthorn compound superfine powder of mutation according to claim 1, suppression cancer and cancer cell specific induction of apoptosis, feature exist
In, the seabuckthorn fruit peel ursolic acid extract the preparation method comprises the following steps:
Seabuckthorn fruit peel is impregnated at least 1 hour with 6 ~ 15 times of 60% ~ 85% ethyl alcohol, using flash under 15 DEG C ~ 35 DEG C normal temperature conditions
Extraction method extracts 0.2h ~ 0.5h, and extracting solution is collected by filtration, and extracts slag and repeats to extract 2 ~ 3 times, obtained extraction is repeatedly extracted in merging
Liquid, then low-temperature negative-pressure closed loop thermo-compression evaporation enrichment facility is used, ethyl alcohol is recycled, and concentrated extracting solution is big to soluble solid
In 40% concentrate, concentrate is dry using low-temperature negative-pressure belt drying unit, and it is thick to obtain seabuckthorn fruit peel ursolic acid extract
Powder.
5. the sea-buckthorn compound superfine powder of mutation according to claim 1, suppression cancer and cancer cell specific induction of apoptosis, feature exist
In, the Ilex kudingcha C.J.Tseng old leaf ursolic acid extract the preparation method comprises the following steps:
Ilex kudingcha C.J.Tseng old leaf is crushed to 10 ~ 20 mesh, is impregnated at least 1 hour with 6 ~ 15 times of 60% ~ 85% ethyl alcohol, 15 DEG C ~
0.2h ~ 0.5h is extracted using homogenate extraction method under 35 DEG C of normal temperature conditions, extracting solution is collected by filtration, slag is extracted and repeats to extract 2 ~ 3 times,
Obtained extracting solution is repeatedly extracted in merging, then uses low-temperature negative-pressure closed loop thermo-compression evaporation enrichment facility, recycles ethyl alcohol, and be concentrated
Extracting solution is greater than 40% concentrate to soluble solid, and concentrate is dry using low-temperature negative-pressure belt drying unit, obtains the winter
Green old leaves of Kudingcha ursolic acid extract coarse powder.
6. the sea-buckthorn compound superfine powder of mutation according to claim 1, suppression cancer and cancer cell specific induction of apoptosis, feature exist
In, the fuling peel triterpene extract the preparation method comprises the following steps:
Fuling peel is crushed to 10 ~ 20 mesh, is impregnated at least 1 hour with 6 ~ 15 times of 60% ~ 85% ethyl alcohol, in 15 DEG C ~ 35 DEG C room temperature items
0.2h ~ 0.5h is extracted using homogenate extraction method under part, extracting solution is collected by filtration, slag is extracted and repeats to extract 2 ~ 3 times, merging repeatedly mentions
The extracting solution obtained, then low-temperature negative-pressure closed loop thermo-compression evaporation enrichment facility is used, ethyl alcohol is recycled, and concentrated extracting solution extremely may be used
Dissolubility solid content is greater than 40% concentrate, and concentrate is dry using low-temperature negative-pressure belt drying unit, obtains fuling peel triterpene and mentions
Take object coarse powder.
7. the sea-buckthorn compound Ultramicro-powder of anti-mutation according to claim 1-6, suppression cancer and cancer cell specific induction of apoptosis
Agent, which is characterized in that sea buckthorn procyanidins > 2.2g, ursolic acid > 1.6g in every 100g sea-buckthorn compound superfine powder.
8. according to the sea-buckthorn compound Ultramicro-powder of the described in any item anti-mutation of claim 3-6, suppression cancer and cancer cell specific induction of apoptosis
Agent, which is characterized in that the low-temperature negative-pressure is that temperature is lower than 50 DEG C, and pressure is higher than -0.098MPa.
9. a kind of preparation method of the sea-buckthorn compound superfine powder as described in claim any one of 1-8, which is characterized in that the system
Preparation Method the following steps are included:
By seabuckthorn seeds procyanidin extract coarse powder, seabuckthorn fruit peel ursolic acid extract coarse powder, Ilex kudingcha C.J.Tseng old leaf ursolic acid
Extract coarse powder and fuling peel triterpene extract coarse powder are proportionally added in three-dimensional mixer and are uniformly mixed, then will mixing
After uniform coarse powder is crushed to the Ultramicro-powder of 500 mesh or more using airslide disintegrating mill, the filling sea-buckthorn compound ultra micro at every bag of 6g
Powder product.
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