CN110035743A - 一种Talazoparib药物组合物及其应用 - Google Patents
一种Talazoparib药物组合物及其应用 Download PDFInfo
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- CN110035743A CN110035743A CN201780011152.3A CN201780011152A CN110035743A CN 110035743 A CN110035743 A CN 110035743A CN 201780011152 A CN201780011152 A CN 201780011152A CN 110035743 A CN110035743 A CN 110035743A
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- talazoparib
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- A61K9/10—Dispersions; Emulsions
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
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- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
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- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
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- A—HUMAN NECESSITIES
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- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
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- A—HUMAN NECESSITIES
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Abstract
一种包含PARP抑制剂Talazoparib的药物组合物及其用于治疗肿瘤的用途,所述组合物具体包含(重量份):Talazoparib 0.1‑200,释放速率调节用辅料0.1‑500,小分子调节剂0‑1000,药用可注射溶剂0‑2000。所述组合物可持续维持Talazoparib在体内的有效血药浓度和PARP酶活性抑制水平。
Description
PCT国内申请,说明书已公开。
Claims (12)
- PCT国内申请,权利要求书已公开。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201611170105.7A CN108210461A (zh) | 2016-12-16 | 2016-12-16 | 一种Talazoparib药物组合物及其应用 |
CN2016111701057 | 2016-12-16 | ||
PCT/CN2017/116573 WO2018108163A1 (zh) | 2016-12-16 | 2017-12-15 | 一种Talazoparib药物组合物及其应用 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN110035743A true CN110035743A (zh) | 2019-07-19 |
CN110035743B CN110035743B (zh) | 2022-04-08 |
Family
ID=62557987
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201611170105.7A Pending CN108210461A (zh) | 2016-12-16 | 2016-12-16 | 一种Talazoparib药物组合物及其应用 |
CN201780011152.3A Active CN110035743B (zh) | 2016-12-16 | 2017-12-15 | 一种Talazoparib药物组合物及其应用 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201611170105.7A Pending CN108210461A (zh) | 2016-12-16 | 2016-12-16 | 一种Talazoparib药物组合物及其应用 |
Country Status (2)
Country | Link |
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CN (2) | CN108210461A (zh) |
WO (1) | WO2018108163A1 (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2024067840A1 (zh) * | 2022-09-30 | 2024-04-04 | 上海济煜医药科技有限公司 | 一种脂质体及其制备方法和应用 |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11246836B2 (en) * | 2018-05-17 | 2022-02-15 | Bluelight Pharmatech Co., Ltd. | Intramuscular depot of decoquinate compositions and method of prophylaxis and treatment thereof |
CN110063932A (zh) * | 2019-04-12 | 2019-07-30 | 浙江大学 | 一种多肽蛋白类药物的缓释组合物制剂及其制备方法 |
US20230201122A1 (en) * | 2021-12-23 | 2023-06-29 | Boston Scientific Medical Device Limited | Chemoembolic compositions and methods of treatment using them |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102171214A (zh) * | 2008-08-06 | 2011-08-31 | 生物马林药物股份有限公司 | 聚(adp-核糖)聚合酶(parp)的二氢吡啶并酞嗪酮抑制剂 |
WO2015192014A1 (en) * | 2014-06-13 | 2015-12-17 | Calithera Biosciences, Inc. | Combination therapy with glutaminase inhibitors |
US20150366882A1 (en) * | 2011-02-03 | 2015-12-24 | Pop Test Oncology Limited Liability Company | System and Method for Diagnosis and Treatment |
WO2016130546A1 (en) * | 2015-02-10 | 2016-08-18 | Memorial Sloan Kettering Cancer Center | Dye-stabilized nanoparticles and methods of their manufacture and therapeutic use |
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2016
- 2016-12-16 CN CN201611170105.7A patent/CN108210461A/zh active Pending
-
2017
- 2017-12-15 WO PCT/CN2017/116573 patent/WO2018108163A1/zh active Application Filing
- 2017-12-15 CN CN201780011152.3A patent/CN110035743B/zh active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102171214A (zh) * | 2008-08-06 | 2011-08-31 | 生物马林药物股份有限公司 | 聚(adp-核糖)聚合酶(parp)的二氢吡啶并酞嗪酮抑制剂 |
US20150366882A1 (en) * | 2011-02-03 | 2015-12-24 | Pop Test Oncology Limited Liability Company | System and Method for Diagnosis and Treatment |
WO2015192014A1 (en) * | 2014-06-13 | 2015-12-17 | Calithera Biosciences, Inc. | Combination therapy with glutaminase inhibitors |
WO2016130546A1 (en) * | 2015-02-10 | 2016-08-18 | Memorial Sloan Kettering Cancer Center | Dye-stabilized nanoparticles and methods of their manufacture and therapeutic use |
Non-Patent Citations (1)
Title |
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JODI BELZ ET AL: "《https://cancerres.aacrjournals.org/content/76/14_Supplement/3900》", 31 July 2016 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2024067840A1 (zh) * | 2022-09-30 | 2024-04-04 | 上海济煜医药科技有限公司 | 一种脂质体及其制备方法和应用 |
Also Published As
Publication number | Publication date |
---|---|
CN110035743B (zh) | 2022-04-08 |
WO2018108163A1 (zh) | 2018-06-21 |
CN108210461A (zh) | 2018-06-29 |
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