CN110025582B - Preparation method of salinomycin particles - Google Patents
Preparation method of salinomycin particles Download PDFInfo
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Abstract
The invention provides a preparation method of salinomycin particles, and belongs to the technical field of antibiotic production for livestock. The preparation method of the salinomycin particles provided by the invention comprises the following steps: mixing salinomycin fine powder with water for first wetting treatment to obtain wet powder; mixing the wet powder with a binder to obtain a wet product; mixing the wet product with water, carrying out second wetting treatment, and then granulating to obtain wet granules; and drying the wet granules to obtain salinomycin granules. The preparation method provided by the invention has the advantages of high granulation rate and good granule uniformity of the salinomycin fine powder, low repeated granulation frequency, high production efficiency, simple process, low cost and energy consumption and capability of realizing clean production.
Description
Technical Field
The invention relates to the technical field of antibiotic production for livestock, and in particular relates to a preparation method of salinomycin particles.
Background
Salinomycin is a monocarboxylic acid polyether special antibiotic for animals, and has strong inhibiting and killing effects on most gram-positive bacteria and various coccidia. Because the drug resistance and cross drug resistance are not easy to generate, the excretion is rapid, and the residual quantity is extremely low, the drug is favored.
The production of hydrochloride granules is that firstly the fermentation filtrate is made into calcium salt, then the plate-frame filtration is carried out, then the wet powder filter cake is crushed and granulated, the obtained granules are dried to obtain semi-finished products, and finally the finished products of the salinomycin granules are obtained by screening. However, in the preparation process of the salinomycin particles, during the processes of crushing, feeding, drying, discharging and screening of wet powder filter cakes into finished products, 30-40% of salinomycin fine powder is generated, so that resource waste is caused, and the production cost is greatly increased.
Disclosure of Invention
The invention aims to provide a preparation method of salinomycin particles, which has the advantages of high granulation rate, low repeated granulation frequency, high production efficiency, simple process, low cost and energy consumption and capability of realizing clean production.
In order to achieve the above object, the present invention provides the following technical solutions:
the invention provides a preparation method of salinomycin particles, which comprises the following steps:
mixing salinomycin fine powder with water for first wetting treatment to obtain wet powder;
mixing the wet powder with a binder to obtain a wet product;
mixing the wet product with water, carrying out second wetting treatment, and then granulating to obtain wet granules;
and drying the wet granules to obtain salinomycin granules.
Preferably, the moisture content of the wet powder is 16-26%.
Preferably, the mass ratio of the salinomycin fine powder to the binder is 1: (0.04-0.09).
Preferably, the binder is a mixture of lignosulfonate and dextrin; the mass ratio of the lignosulfonate to the dextrin is (1-6): 1.
preferably, the dextrin comprises one or more of maltodextrin, dry dextrin and cyclodextrin.
Preferably, the first wetting pretreatment is carried out under the condition of stirring, the stirring speed is 20-30 rpm, and the time is 10-15 min.
Preferably, the mixing of the wet powder and the adhesive is carried out under the condition of stirring, the stirring speed is 20-30 rpm, and the time is 30-60 min.
Preferably, the water content of the material obtained after the second wetting treatment is 32-48%.
Preferably, the drying temperature is 50-140 ℃, and the drying time is 30-60 min.
Preferably, the drying is carried out in a boiling dryer; the air inlet temperature of the fluidized drying machine is controlled to be 110-140 ℃, the box body temperature is controlled to be 60-65 ℃, and the air outlet temperature is controlled to be 50-65 ℃.
The invention provides a preparation method of salinomycin particles, which comprises the following steps: mixing salinomycin fine powder with water for first wetting treatment to obtain wet powder; mixing the wet powder with a binder to obtain a wet product; mixing the wet product with water, carrying out second wetting treatment, and then granulating to obtain wet granules; and drying the wet granules to obtain salinomycin granules. The preparation method provided by the invention has the advantages that the granulation rate of the salinomycin fine powder is high, the uniformity of the granules is good, and the granulation rate reaches over 93.8 percent as shown in the example result. The preparation method provided by the invention has the advantages of low repeated granulation frequency, high production efficiency, simple process, low cost and energy consumption and capability of realizing clean production.
Drawings
FIG. 1 is a flow chart of the preparation of salinomycin particles of the invention.
Detailed Description
The invention provides a preparation method of salinomycin particles, which comprises the following steps:
mixing salinomycin fine powder with water, and carrying out first wetting treatment to obtain wet powder;
mixing the wet powder with a binder to obtain a wet product;
mixing the wet product with water, carrying out second wetting treatment, and then granulating to obtain wet granules;
and drying the wet granules to obtain salinomycin granules.
The salinomycin fine powder and water are mixed for first wetting treatment to obtain wet powder. In the invention, the source of the salinomycin fine powder is preferably fine powder screened in the salinomycin production process. In the invention, the first wetting pretreatment is preferably carried out under a stirring condition, and the stirring speed is preferably 20-30 rpm, more preferably 23-28 rpm; the stirring time is preferably 10-15 min, and more preferably 10-12 min.
In the invention, the moisture content of the wet powder is preferably 16-26%, and more preferably 17-23%. In the invention, too high or too low water content in the wet powder can cause low acting force between the wet powder and the adhesive, so that granulation cannot be performed, and the invention controls the water content to be 16-26%, thereby being beneficial to improving the granulation rate. In the present invention, the water content is preferably measured by a rapid moisture meter.
After the wet powder is obtained, the wet powder is mixed with the adhesive to obtain a wet product. In the invention, the mass ratio of the salinomycin fine powder to the binder is preferably 1: (0.04 to 0.09), more preferably 1: (0.05 to 0.07), most preferably 1: (0.06-0.07). In the present invention, the binder preferably comprises a mixture of lignosulfonate and dextrin; the mass ratio of the lignosulfonate to the dextrin is preferably (1-6): 1, more preferably (2-6): 1, most preferably (4-6): 1. in the present invention, the lignosulfonate preferably comprises calcium lignosulfonate and/or sodium lignosulfonate; the dextrin preferably comprises one or more of maltodextrin, dry dextrin and cyclodextrin, and more preferably comprises maltodextrin, dry dextrin or cyclodextrin. In the invention, the dextrin is preferably used in the form of a dextrin aqueous solution, and the mass concentration of the dextrin aqueous solution is preferably less than 10%, and more preferably 5-10%. In the invention, when the dextrin powder is used in a form of dextrin dry powder, the dextrin powder is agglomerated into small balls, so that the mixing is uneven, and the granulation effect is influenced; in the invention, the dextrin is used in the form of dextrin water solution, is easy to be uniformly mixed with other raw materials, shortens the stirring time, and can greatly improve the adhesiveness of the adhesive, thereby improving the granulation rate and the granule uniformity.
In the present invention, the wet powder and the binder are preferably mixed by first mixing the wet powder and the lignosulfonate, and then adding the aqueous dextrin solution to mix them. In the invention, the mixing of the wet powder and the adhesive is preferably carried out under the condition of stirring, and the stirring speed is preferably 20-30 rpm, more preferably 23-28 rpm; the stirring time is preferably 30-60 min, and more preferably 50-60 min. The invention can improve the production efficiency while ensuring the product quality by controlling the mixing speed and time.
After a wet product is obtained, the wet product and water are mixed, subjected to second wetting treatment and granulated to obtain wet granules. In the invention, the water content of the material obtained after the second wetting treatment is preferably 32-48%, more preferably 35-45%, and most preferably 40-45%. In the present invention, the water content is preferably measured by a rapid moisture meter. In the invention, too high water content can cause the granulated material obtained after the second wetting treatment to be too soft and not be granulated and molded; too low a moisture content can result in too dry granulation material and poor granulation; according to the invention, the water content of the granulating material is controlled, so that the granulating material can be ensured to be in an optimal state, and the granulating efficiency and the granulating rate can be improved.
In the present invention, the granulation is preferably carried out in a rotary granulator. The frequency of the rotary granulator is not particularly limited in the present invention, and any frequency known in the art may be used.
After the wet granules are obtained, the wet granules are dried to obtain salinomycin granules. In the present invention, the drying is preferably carried out in a boiling dryer. In the present invention, the granules obtained after completion of granulation are preferably conveyed to a fluidized dryer through a conveyor belt to be dried. In the invention, the drying temperature is preferably 50-140 ℃; specifically, the air inlet temperature of the fluidized drying machine is preferably controlled to be 110-140 ℃, the box body temperature is 60-65 ℃, the air outlet temperature is 50-65 ℃, the air inlet temperature is preferably 120-140 ℃, the box body temperature is 60-65 ℃, and the air outlet temperature is 50-55 ℃. In the invention, the drying time is preferably the time for the materials to stay in the box body; the drying time is preferably 30-60 min, and more preferably 40-50 min. In the invention, the drying temperature is too low, and the drying time is too short, so that the wet granules cannot be dried; too high a temperature and too long a time can result in the wet pellets being scorched. The invention ensures the granularity and the grain diameter as well as the disintegration degree by controlling the drying time and the temperature, thereby improving the granulation rate and the grain uniformity.
The salinomycin particles obtained by the preparation method provided by the invention basically have no salinomycin fine powder, and do not need to be sieved, so that the preparation process is simplified, the cost and the energy consumption are saved, and the preparation flow chart of the salinomycin particles is shown in figure 1.
The technical solution of the present invention will be clearly and completely described below with reference to the embodiments of the present invention. It is to be understood that the described embodiments are merely exemplary of the invention, and not restrictive of the full scope of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
(1) Putting 1000kg of salinomycin powder and water into a coulter mixer, stirring for 15min at 25rpm, and carrying out first wetting treatment to obtain wet powder with the water content of 16.7%;
(2) dissolving 10kg of dextrin in 100kg of water to obtain a dextrin aqueous solution, mixing the wet powder, 25kg of sodium lignosulfonate and 25kg of calcium lignosulfonate, adding the dextrin aqueous solution, and stirring for 50min at 25rpm to mix to obtain a wet product;
(3) placing the wet product and water in a stirrer, mixing, feeding water, performing second wetting treatment to obtain a granulated material with the water content of 45%, and adding the granulated material into a rotary granulator for granulation to obtain wet granules;
(4) and conveying the wet granules into a boiling dryer through a conveyer belt for drying for 45min, wherein the temperature parameters of the boiling dryer are as follows: the air inlet temperature is 110-120 ℃, the box body temperature is 60-65 ℃, the air outlet temperature is 50-55 ℃, and salinomycin particles are obtained.
Example 2
(1) Putting 1000kg of salinomycin powder and water into a coulter mixer, stirring for 10min at 25rpm, and carrying out first wetting treatment to obtain wet powder with the water content of 20%;
(2) dissolving 10kg of dextrin in 100kg of water to obtain a dextrin aqueous solution, mixing the wet powder, 30kg of sodium lignosulfonate and 25kg of calcium lignosulfonate, adding the dextrin aqueous solution, and stirring for 50min at 25rpm to mix to obtain a wet product;
(3) placing the wet product and water in a stirrer, mixing, feeding water, performing second wetting treatment to obtain a granulated material with the water content of 45%, and adding the granulated material into a rotary granulator for granulation to obtain wet granules;
(4) and conveying the wet granules into a boiling dryer through a conveyer belt for drying for 45min, wherein the temperature parameters of the boiling dryer are as follows: the air inlet temperature is 110-120 ℃, the box body temperature is 60-65 ℃, the air outlet temperature is 50-55 ℃, and salinomycin particles are obtained.
Example 3
(1) Putting 1000kg of salinomycin powder and water into a coulter mixer, stirring for 15min at 25rpm, and carrying out first wetting treatment to obtain wet powder with the water content of 18%;
(2) dissolving 10kg of dextrin in 100kg of water to obtain a dextrin aqueous solution, mixing the wet powder with 50kg of calcium lignosulfonate, adding the dextrin aqueous solution, and stirring for 50min at 25rpm to obtain a wet product;
(3) placing the wet product and water in a stirrer, mixing, feeding water, performing second wetting treatment to obtain a granulated material with the water content of 45%, and adding the granulated material into a rotary granulator for granulation to obtain wet granules;
(4) and conveying the wet granules into a boiling dryer through a conveyer belt for drying for 45min, wherein the temperature parameters of the boiling dryer are as follows: the air inlet temperature is 110-120 ℃, the box body temperature is 60-65 ℃, the air outlet temperature is 50-55 ℃, and salinomycin particles are obtained.
Example 4
(1) Putting 1000kg of salinomycin powder and water into a coulter mixer, stirring for 15min at 25rpm, and carrying out first wetting treatment to obtain wet powder with the water content of 17%;
(2) dissolving 10kg of dextrin in 100kg of water to obtain a dextrin aqueous solution, mixing the wet powder with 50kg of calcium lignosulfonate, adding the dextrin aqueous solution, and stirring for 50min at 25rpm to obtain a wet product;
(3) placing the wet product and water in a stirrer, mixing, feeding water, performing second wetting treatment to obtain a granulated material with the water content of 40%, and adding the granulated material into a rotary granulator for granulation to obtain wet granules;
(4) and conveying the wet granules into a boiling dryer through a conveyer belt for drying for 45min, wherein the temperature parameters of the boiling dryer are as follows: the air inlet temperature is 110-120 ℃, the box body temperature is 60-65 ℃, the air outlet temperature is 50-55 ℃, and salinomycin particles are obtained.
Comparative example 1
(1) Putting 1000kg of salinomycin powder and water into a coulter mixer, stirring for 15min at 25rpm, and carrying out first wetting treatment to obtain wet powder with the water content of 13%;
(2) dissolving 10kg of dextrin in 100kg of water to obtain a dextrin aqueous solution, mixing the wet powder with 50kg of calcium lignosulfonate, adding the dextrin aqueous solution, and stirring for 50min at 25rpm to obtain a wet product;
(3) placing the wet product and water in a stirrer, mixing, feeding water, performing second wetting treatment to obtain a granulated material with the water content of 30%, and adding the granulated material into a rotary granulator for granulation to obtain wet granules;
(4) and conveying the wet granules into a boiling dryer through a conveyer belt for drying for 45min, wherein the temperature parameters of the boiling dryer are as follows: the air inlet temperature is 110-120 ℃, the box body temperature is 60-65 ℃, the air outlet temperature is 50-55 ℃, and salinomycin particles are obtained.
Comparative example 2
(1) Putting 1000kg of salinomycin powder and water into a coulter mixer, stirring for 15min at 25rpm, and carrying out first wetting treatment to obtain wet powder with the water content of 23%;
(2) dissolving 10kg of dextrin in 100kg of water to obtain a dextrin aqueous solution, mixing the wet powder with 50kg of calcium lignosulfonate, adding the dextrin aqueous solution, and stirring for 50min at 25rpm to obtain a wet product;
(3) placing the wet product and water in a stirrer, mixing, feeding water, performing second wetting treatment to obtain a granulated material with the water content of 50%, and adding the granulated material into a rotary granulator for granulation to obtain wet granules;
(4) and conveying the wet granules into a boiling dryer through a conveyer belt for drying for 45min, wherein the temperature parameters of the boiling dryer are as follows: the air inlet temperature is 110-120 ℃, the box body temperature is 60-65 ℃, the air outlet temperature is 50-55 ℃, and salinomycin particles are obtained.
Comparative example 3
(1) Putting 1000kg of salinomycin powder and water into a coulter mixer, stirring for 15min at 25rpm, and carrying out first wetting treatment to obtain wet powder with the water content of 16.7%;
(2) dissolving 30kg of dextrin in 100kg of water to obtain a dextrin water solution, and stirring the wet powder and the dextrin water solution for 50min at 25rpm to mix to obtain a wet product;
(3) placing the wet product and water in a stirrer, mixing, feeding water, performing second wetting treatment to obtain a granulated material with the water content of 40%, and adding the granulated material into a rotary granulator for granulation to obtain wet granules;
(4) and conveying the wet granules into a boiling dryer through a conveyer belt for drying for 45min, wherein the temperature parameters of the boiling dryer are as follows: the air inlet temperature is 110-120 ℃, the box body temperature is 60-65 ℃, the air outlet temperature is 50-55 ℃, and salinomycin particles are obtained.
Comparative example 4
(1) Putting 1000kg of salinomycin powder and water into a coulter mixer, stirring for 15min at 25rpm, and carrying out first wetting treatment to obtain wet powder with the water content of 16.7%;
(2) stirring the wet powder, 25kg of sodium lignosulfonate and 25kg of calcium lignosulfonate for 50min at 25rpm, and mixing to obtain a wet product;
(3) placing the wet product and water in a stirrer, mixing, feeding water, performing second wetting treatment to obtain a granulated material with the water content of 45%, and adding the granulated material into a rotary granulator for granulation to obtain wet granules;
(4) and conveying the wet granules into a boiling dryer through a conveyer belt for drying for 45min, wherein the temperature parameters of the boiling dryer are as follows: the air inlet temperature is 110-120 ℃, the box body temperature is 60-65 ℃, the air outlet temperature is 50-55 ℃, and salinomycin particles are obtained.
Comparative example 5
(1) Putting 1000kg of salinomycin powder and water into a coulter mixer, stirring for 15min at 25rpm, and carrying out first wetting treatment to obtain wet powder with the water content of 23%;
(2) dissolving 8kg of dextrin in 100kg of water to obtain a dextrin aqueous solution, mixing the wet powder, 26kg of sodium lignosulfonate and 26kg of calcium lignosulfonate, adding the dextrin aqueous solution, and stirring for 50min at 25rpm to obtain a wet product;
(3) placing the wet product and water in a stirrer, mixing, feeding water, performing second wetting treatment to obtain a granulated material with the water content of 45%, and adding the granulated material into a rotary granulator for granulation to obtain wet granules;
(4) and conveying the wet granules into a boiling dryer through a conveyer belt for drying for 45min, wherein the temperature parameters of the boiling dryer are as follows: the air inlet temperature is 130 ℃, the box body temperature is 70 ℃, and the air outlet temperature is 60 ℃, so that salinomycin particles are obtained.
Comparative example 6
(1) Putting 1000kg of salinomycin powder and water into a coulter mixer, stirring for 15min at 25rpm, and carrying out first wetting treatment to obtain wet powder with the water content of 23%;
(2) dissolving 40kg of dextrin in 100kg of water to obtain a dextrin aqueous solution, mixing the wet powder, 10kg of sodium lignosulfonate and 10kg of calcium lignosulfonate, adding the dextrin aqueous solution, and stirring for 50min at 25rpm to mix to obtain a wet product;
(3) placing the wet product and water in a stirrer, mixing, feeding water, performing second wetting treatment to obtain a granulated material with the water content of 45%, and adding the granulated material into a rotary granulator for granulation to obtain wet granules;
(4) and conveying the wet granules into a boiling dryer through a conveyer belt for drying for 45min, wherein the temperature parameters of the boiling dryer are as follows: the air inlet temperature is 110-120 ℃, the box body temperature is 60-65 ℃, the air outlet temperature is 50-55 ℃, and salinomycin particles are obtained.
Comparative example 7
(1) Putting 1000kg of salinomycin powder and water into a coulter mixer, stirring for 15min at 25rpm, and carrying out first wetting treatment to obtain wet powder with the water content of 23%;
(2) dissolving 60kg of sucrose in 100kg of water to obtain a sucrose solution, and stirring the wet powder and the sucrose solution for 50min at 25rpm to mix to obtain a wet product;
(3) placing the wet product and water in a stirrer, mixing, feeding water, performing second wetting treatment to obtain a granulated material with the water content of 45%, and adding the granulated material into a rotary granulator for granulation to obtain wet granules;
(4) and conveying the wet granules into a boiling dryer through a conveyer belt for drying for 45min, wherein the temperature parameters of the boiling dryer are as follows: the air inlet temperature is 110-120 ℃, the box body temperature is 60-65 ℃, the air outlet temperature is 50-55 ℃, and salinomycin particles are obtained.
Comparative example 8
(1) Putting 1000kg of salinomycin powder and water into a coulter mixer, stirring for 15min at 25rpm, and carrying out first wetting treatment to obtain wet powder with the water content of 20%;
(2) dissolving 10kg of dextrin in 100kg of water to obtain a dextrin aqueous solution, mixing the wet powder, 25kg of sodium lignosulfonate and 25kg of calcium lignosulfonate, adding the dextrin aqueous solution, and stirring for 50min at 25rpm to mix to obtain a wet product;
(3) placing the wet product and water in a stirrer, mixing, feeding water, performing second wetting treatment to obtain a granulated material with the water content of 45%, and adding the granulated material into a rotary granulator for granulation to obtain wet granules;
(4) and conveying the wet granules into a boiling dryer through a conveyer belt for drying for 45min, wherein the temperature parameters of the boiling dryer are as follows: the air inlet temperature is 95-105 ℃, the box body temperature is 50-55 ℃, the air outlet temperature is 40-45 ℃, and salinomycin particles are obtained.
Comparative example 9
(1) Putting 1000kg of salinomycin powder and water into a coulter mixer, stirring for 15min at 25rpm, and carrying out first wetting treatment to obtain wet powder with the water content of 23%;
(2) dissolving 10kg of dextrin in 100kg of water to obtain a dextrin aqueous solution, mixing the wet powder, 25kg of sodium lignosulfonate and 25kg of calcium lignosulfonate, adding the dextrin aqueous solution, and stirring for 50min at 25rpm to mix to obtain a wet product;
(3) placing the wet product and water in a stirrer, mixing, feeding water, performing second wetting treatment to obtain a granulated material with the water content of 45%, and adding the granulated material into a rotary granulator for granulation to obtain wet granules;
(4) and conveying the wet granules into a boiling dryer through a conveyer belt for drying for 45min, wherein the temperature parameters of the boiling dryer are as follows: the air inlet temperature is 150-160 ℃, the box body temperature is 70-75 ℃, the air outlet temperature is 70-75 ℃, and salinomycin particles are obtained.
Test example
The salinomycin particles prepared in examples 1-4 and comparative examples 1-9 were sieved with an 80-mesh sieve, the percentage of particles on the sieve to the total mass of the test sample, i.e., the particle yield, was measured, and the particle uniformity was observed, with the test results shown in table 1.
TABLE 1 granulation Rate and particle uniformity test results
As can be seen from table 1, in comparative examples 1 to 2, the moisture content of the material after the first wetting treatment and/or the second wetting treatment is too low, the material is too dry, and the produced particles are not full enough and are easy to break, so that the granulation rate is low, and the particle size is uniform and not good; the moisture content of the material after the first wetting treatment and/or the second wetting treatment is too high, the material is wet, the granulation speed is influenced, and the produced particles are easy to bond, so that large particles in the dried salinomycin particles are relatively more, and the uniformity of the particles is poor. As shown in comparative examples 3 to 4, the use of lignosulfonate or dextrin alone as a binder resulted in poor viscosity, no internal and external coating effects, and thus low granulation rate and poor particle uniformity; in comparative example 5, it is known that too large mass ratio of lignosulfonate to dextrin in the binder causes large viscosity, and the produced particles are not easy to crack in the drying process, resulting in more large particles; comparative example 6 shows that the mass ratio of lignosulfonate to dextrin in the binder was too small, resulting in insufficient binding force, and further, low granulation rate and poor uniformity of granules. Comparative example 7 shows that sucrose as a binder had irregular particles, poor uniformity and low granulation rate; in comparative examples 8 to 9, it is found that too high or too low drying temperature causes scorching, and the binder fails or is not dried, resulting in a non-hard particle size and also in the generation of lumps, resulting in a low granulation rate and poor particle uniformity. According to the invention, the water content of the material after the first wetting treatment and/or the second wetting treatment is controlled, the mixture of lignosulfonate and dextrin in a specific ratio is used as a binding agent in a matching manner, and the specific temperature parameter of drying is controlled, so that the granulation rate is greatly improved, and the uniformity of granules is good.
The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, various modifications and decorations can be made without departing from the principle of the present invention, and these modifications and decorations should also be regarded as the protection scope of the present invention.
Claims (6)
1. A preparation method of salinomycin particles is characterized by comprising the following steps:
mixing salinomycin fine powder with water for first wetting treatment to obtain wet powder;
mixing the wet powder with a binder to obtain a wet product;
mixing the wet product with water, carrying out second wetting treatment, and then granulating to obtain wet granules;
drying the wet granules to obtain salinomycin granules;
the moisture content of the wet powder is 16-26%; the adhesive is a mixture of lignosulfonate and dextrin; the mass ratio of the lignosulfonate to the dextrin is (1-6): 1; the water content of the material obtained after the second wetting treatment is 32-48%; the drying temperature is 50-140 ℃, and the drying time is 30-60 min.
2. The preparation method according to claim 1, wherein the mass ratio of the salinomycin fine powder to the binder is 1: (0.04-0.09).
3. The method of claim 1, wherein the dextrin comprises one or more of maltodextrin, dry dextrin and cyclodextrin.
4. The method according to claim 1, wherein the first wet pretreatment is carried out under stirring at a speed of 20 to 30rpm for 10 to 15 min.
5. The method according to claim 1, wherein the mixing of the wet powder and the binder is carried out under stirring at a speed of 20 to 30rpm for 30 to 60 min.
6. The method of claim 1, wherein the drying is performed in a boiling dryer; the air inlet temperature of the fluidized drying machine is controlled to be 110-140 ℃, the box body temperature is controlled to be 60-65 ℃, and the air outlet temperature is controlled to be 50-65 ℃.
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| CN101926776A (en) * | 2010-08-13 | 2010-12-29 | 清远容大生物工程有限公司 | Salinomycin sodium suspension as well as preparation method and application thereof |
| CN108309953A (en) * | 2018-03-30 | 2018-07-24 | 内蒙古拜克生物有限公司 | A kind of production method of salinomycin microcapsule granule |
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| CN101926776A (en) * | 2010-08-13 | 2010-12-29 | 清远容大生物工程有限公司 | Salinomycin sodium suspension as well as preparation method and application thereof |
| CN108309953A (en) * | 2018-03-30 | 2018-07-24 | 内蒙古拜克生物有限公司 | A kind of production method of salinomycin microcapsule granule |
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