CN110025582A - A kind of preparation method of salinomycin particle - Google Patents
A kind of preparation method of salinomycin particle Download PDFInfo
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Abstract
The present invention provides a kind of preparation methods of salinomycin particle, belong to veterinary antibiotic production technical field.The preparation method of salinomycin particle provided by the invention, comprising the following steps: salinomycin fine powder and water are mixed and carry out the first wettability treatment, obtains wet-milling；The wet-milling and adhesive are mixed, wet product is obtained；The wet product and water are mixed and are granulated after carrying out the second wettability treatment, wet grain is obtained；The wet grain is dried, salinomycin particle is obtained.Preparation method salinomycin fine powder granulating rate provided by the invention is high, and particle uniformity is good, and preparation method provided by the invention repetition granulation frequency is low, high production efficiency, and simple process, low energy consumption for cost, can be realized clean manufacturing.
Description
Technical field
The present invention relates to veterinary antibiotic production technical fields, and in particular to a kind of preparation method of salinomycin particle.
Background technique
Salinomycin is monocarboxylic acid polyethers animal specific antibiotic, is had to most of gram-positive bacterias and various coccidias
Stronger inhibition and killing effect.Since it is not likely to produce drug resistance and cross-resistance, rapidly, residual quantity is extremely low, standby for excretion
Favored.
The production of hydrochloric acid crude granule is calcium salt first to be made in ferment filtrate, then carry out plate-frame filtering, then wet-milling filter cake
Be crushed and be granulated again, gained particulate material is dried to obtain semi-finished product, last sub-sieve obtains salinomycin particle finished product.However
In above-mentioned salinomycin particle preparation process, wet-milling filter cake is broken, feeding, drying, discharging and sub-sieve switch in Finished product processThe, all can
The salinomycin fine powder for generating 30~40%, causes the waste of resource, production cost also increases substantially.
Summary of the invention
The purpose of the present invention is to provide a kind of preparation method of salinomycin particle, preparation method granulating provided by the invention
Rate is high, repetition granulation frequency is low, high production efficiency, and low energy consumption, can be realized clean manufacturing for simple process, cost.
In order to achieve the above-mentioned object of the invention, the present invention the following technical schemes are provided:
The present invention provides a kind of preparation methods of salinomycin particle, comprising the following steps:
Salinomycin fine powder and water are mixed and carry out the first wettability treatment, obtains wet-milling；
The wet-milling and adhesive are mixed, wet product is obtained；
The wet product and water are mixed and are granulated after carrying out the second wettability treatment, wet grain is obtained；
The wet grain is dried, salinomycin particle is obtained.
Preferably, the moisture content of the wet-milling is 16~26%.
Preferably, the mass ratio of the salinomycin fine powder and adhesive is 1:(0.04~0.09).
Preferably, described adhesive is the mixture of lignosulfonates and dextrin；The lignosulfonates and dextrin
Mass ratio be (1~6): 1.
Preferably, the dextrin includes one or more of maltodextrin, dry dextrin and cyclodextrin.
Preferably, the first wetting pretreatment carries out under agitation, and the speed of the stirring is 20~30rpm,
Time is 10~15min.
Preferably, the wet-milling and adhesive mixing carry out under agitation, and the speed of the stirring is 20~
30rpm, time are 30~60min.
Preferably, the moisture content of resulting material is 32~48% after second wettability treatment.
Preferably, the temperature of the drying is 50~140 DEG C, and the time of the drying is 30~60min.
Preferably, the drying carries out in boiling drier；Control the boiling drier inlet air temperature be 110~
140 DEG C, spin manifold temperature is 60~65 DEG C, and leaving air temp is 50~65 DEG C.
The present invention provides a kind of preparation methods of salinomycin particle, comprising the following steps: mixes salinomycin fine powder and water
It closes and carries out the first wettability treatment, obtain wet-milling；The wet-milling and adhesive are mixed, wet product is obtained；The wet product and water are mixed
It closes and is granulated after carrying out the second wettability treatment, obtain wet grain；The wet grain is dried, salinomycin particle is obtained.The present invention mentions
The preparation method salinomycin fine powder granulating rate of confession is high, and particle uniformity is good, and as shown in embodiment result, granulating rate is up to 93.8%
More than.And preparation method provided by the invention repeats to be granulated that frequency is low, high production efficiency, and simple process, low energy consumption for cost, energy
Enough realize clean manufacturing.
Detailed description of the invention
Fig. 1 is the preparation flow figure of salinomycin particle of the present invention.
Specific embodiment
The present invention provides a kind of preparation methods of salinomycin particle, comprising the following steps:
Salinomycin fine powder and water are mixed, the first wettability treatment is carried out, obtains wet-milling；
The wet-milling and adhesive are mixed, wet product is obtained；
The wet product and water are mixed and are granulated after carrying out the second wettability treatment, wet grain is obtained；
The wet grain is dried, salinomycin particle is obtained.
Salinomycin fine powder and water are mixed and carry out the first wettability treatment by the present invention, obtain wet-milling.In the present invention, the salt
The source of mycin fine powder is preferably the fine powder screened out in salinomycin production process.In the present invention, the pre- place of the first wetting
Reason preferably carries out under agitation, and the speed of the stirring is preferably 20~30rpm, more preferably 23~28rpm；It is described to stir
The time mixed is preferably 10~15min, more preferably 10~12min.
In the present invention, the moisture content of the wet-milling is preferably 16~26%, and more preferably 17~23%.In the present invention
In, the too high or too low active force that will lead between wet-milling and adhesive of moisture content is low in the wet-milling, and then leads to not be granulated,
Moisture control is 16~26% by the present invention, is conducive to improve granulating rate.In the present invention, the moisture content preferably uses fastly
Fast moisture determination instrument is measured.
After obtaining wet-milling, the present invention mixes the wet-milling and adhesive, obtains wet product.In the present invention, the salt is mould
The mass ratio of plain fine powder and adhesive is preferred 1:(0.04~0.09), more preferably 1:(0.05~0.07), most preferably 1:
(0.06~0.07).In the present invention, described adhesive preferably includes the mixture of lignosulfonates sulfonate and dextrin；Institute
The mass ratio for stating lignosulfonates sulfonate and dextrin is preferably (1~6): 1, more preferably (2~6): 1, most preferably (4
~6): 1.In the present invention, the lignosulfonates preferably include calcium lignosulfonate and/or sodium lignin sulfonate；It is described
Dextrin preferably includes one or more of maltodextrin, dry dextrin and cyclodextrin, more preferably include maltodextrin, dry dextrin or
Cyclodextrin.In the present invention, the dextrin uses preferably in the form of dextrin in aqueous solution when in use, the matter of the dextrin in aqueous solution
Amount concentration is preferably less than 10%, more preferably 5~10%.In the present invention, with dextrin dry powder form using when form bead,
It causes mixing uneven, influences granulation outcome；In the present invention, the dextrin is used in the form of dextrin in aqueous solution, be easy with
Other raw materials mix, and shorten mixing time, can greatly improve the adhesiveness of adhesive, and then raising granulating rate and particle are uniform
Property.
In the present invention, the wet-milling and the mode of adhesive mixing preferably first mix wet-milling and lignosulfonates
It closes, dextrin in aqueous solution is then added and is mixed.In the present invention, the wet-milling and adhesive mix preferably under agitation
It carries out, the speed of the stirring is preferably 20~30rpm, more preferably 23~28rpm；The time of the stirring is preferably 30~
60min, more preferably 50~60min.The present invention, can be while guaranteeing product quality by control mixing velocity and time
Improve production efficiency.
After obtaining wet product, the present invention is granulated after the wet product and water are mixed the second wettability treatment of progress, obtains wet grain.?
In the present invention, the moisture content of resulting material is preferably 32~48% after second wettability treatment, and more preferably 35~45%, most
Preferably 40~45%.In the present invention, the moisture content is preferably measured using rapid moisture analyzer.In the present invention
In, the too high granulation material obtained after second wettability treatment that will lead to of moisture content is excessively soft, is unable to granulating and forming；Moisture content is too
Low too dry, the bad granulation that will lead to the granulation material；The present invention can guarantee institute by controlling the granulation material water ratio
It states granulation material and is in optimum state, to be conducive to improve granulation efficiency and granulating rate.
In the present invention, the granulation is preferably carried out in rotary pelleting machine.Frequency of the present invention for the rotary pelleting machine
Rate is not particularly limited, using frequency well known in the art.
After obtaining wet grain, the wet grain is dried the present invention, obtains salinomycin particle.In the present invention, described dry
It is dry to be carried out preferably in boiling drier.In the present invention, the particle obtained after the completion of being granulated is preferably transmitted to boiling through conveyer belt
Drying machine is risen to be dried.In the present invention, the temperature of the drying is preferably 50~140 DEG C；Specifically, it is preferred that described in control
The inlet air temperature of boiling drier is 110~140 DEG C, and spin manifold temperature is 60~65 DEG C, and leaving air temp is 50~65 DEG C, preferably
Inlet air temperature is 120~140 DEG C, and spin manifold temperature is 60~65 DEG C, and leaving air temp is 50~55 DEG C.In the present invention, described dry
The dry time is preferably material residence time in cabinet；The time of the drying is preferably 30~60min, and more preferably 40
~50min.In the present invention, the drying temperature is too low, the time is too short, and will cause the wet grain can not dry；Temperature is excessively high,
Overlong time will lead to the wet grain by adustion.The present invention ensures granule size and partial size by control drying time and temperature,
And degree of bursting apart, and then improve granulating rate and particle uniformity.
Exist substantially without salinomycin fine powder in the product salinomycin particle obtained using preparation method provided by the invention, nothing
Sieving processing need to be carried out, preparation process is simplified, has saved cost energy consumption, the preparation flow figure of the salinomycin particle such as Fig. 1
It is shown.
Below in conjunction with the embodiment in the present invention, the technical solution in the present invention is clearly and completely described.It is aobvious
So, described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.Based on the reality in the present invention
Example is applied, every other embodiment obtained by those of ordinary skill in the art without making creative efforts all belongs to
In the scope of protection of the invention.
Embodiment 1
(1) 1000kg salinomycin powder and water are placed in colter mixer, stir 15min under the conditions of 25rpm, carry out the
One wettability treatment obtains the wet-milling that moisture content is 16.7%；
(2) 10kg dextrin is dissolved in 100kg water and obtains dextrin in aqueous solution, by the wet-milling, 25kg sodium lignin sulfonate
It is mixed with 25kg calcium lignosulfonate, dextrin in aqueous solution is added, 50min is stirred under the conditions of 25rpm and is mixed, is obtained wet
Product；
(3) wet product and water are placed in the wet processing of stirrer for mixing water inlet second, obtaining moisture content is 45%
It is granulated material, gained granulation material is added in rotary pelleting machine and is granulated, wet grain is obtained；
(4) the wet grain is sent into boiling drier through conveyer belt and 45min is dried, wherein boiling drier
Temperature parameter are as follows: inlet air temperature is 110~120 DEG C, and spin manifold temperature is 60~65 DEG C, and leaving air temp is 50~55 DEG C, obtains salt
Mycin particle.
Embodiment 2
(1) 1000kg salinomycin powder and water are placed in colter mixer, stir 10min under the conditions of 25rpm, carry out the
One wettability treatment obtains the wet-milling that moisture content is 20%；
(2) 10kg dextrin is dissolved in 100kg water and obtains dextrin in aqueous solution, by the wet-milling, 30kg sodium lignin sulfonate
It is mixed with 25kg calcium lignosulfonate, dextrin in aqueous solution is added, 50min is stirred under the conditions of 25rpm and is mixed, is obtained wet
Product；
(3) wet product and water are placed in the wet processing of stirrer for mixing water inlet second, obtaining moisture content is 45%
It is granulated material, gained granulation material is added in rotary pelleting machine and is granulated, wet grain is obtained；
(4) the wet grain is sent into boiling drier through conveyer belt and 45min is dried, wherein boiling drier
Temperature parameter are as follows: inlet air temperature is 110~120 DEG C, and spin manifold temperature is 60~65 DEG C, and leaving air temp is 50~55 DEG C, obtains salt
Mycin particle.
Embodiment 3
(1) 1000kg salinomycin powder and water are placed in colter mixer, stir 15min under the conditions of 25rpm, carry out the
One wettability treatment obtains the wet-milling that moisture content is 18%；
(2) 10kg dextrin is dissolved in 100kg water and obtains dextrin in aqueous solution, by the wet-milling and 50kg calcium lignosulfonate
Dextrin in aqueous solution is added in mixing, and 50min is stirred under the conditions of 25rpm and is mixed, wet product is obtained；
(3) wet product and water are placed in the wet processing of stirrer for mixing water inlet second, obtaining moisture content is 45%
It is granulated material, gained granulation material is added in rotary pelleting machine and is granulated, wet grain is obtained；
(4) the wet grain is sent into boiling drier through conveyer belt and 45min is dried, wherein boiling drier
Temperature parameter are as follows: inlet air temperature is 110~120 DEG C, and spin manifold temperature is 60~65 DEG C, and leaving air temp is 50~55 DEG C, obtains salt
Mycin particle.
Embodiment 4
(1) 1000kg salinomycin powder and water are placed in colter mixer, stir 15min under the conditions of 25rpm, carry out the
One wettability treatment obtains the wet-milling that moisture content is 17%；
(2) 10kg dextrin is dissolved in 100kg water and obtains dextrin in aqueous solution, by the wet-milling and 50kg calcium lignosulfonate
Dextrin in aqueous solution is added in mixing, and 50min is stirred under the conditions of 25rpm and is mixed, wet product is obtained；
(3) wet product and water are placed in the wet processing of stirrer for mixing water inlet second, obtaining moisture content is 40%
It is granulated material, gained granulation material is added in rotary pelleting machine and is granulated, wet grain is obtained；
(4) the wet grain is sent into boiling drier through conveyer belt and 45min is dried, wherein boiling drier
Temperature parameter are as follows: inlet air temperature is 110~120 DEG C, and spin manifold temperature is 60~65 DEG C, and leaving air temp is 50~55 DEG C, obtains salt
Mycin particle.
Reference examples 1
(1) 1000kg salinomycin powder and water are placed in colter mixer, stir 15min under the conditions of 25rpm, carry out the
One wettability treatment obtains the wet-milling that moisture content is 13%；
(2) 10kg dextrin is dissolved in 100kg water and obtains dextrin in aqueous solution, by the wet-milling and 50kg calcium lignosulfonate
Dextrin in aqueous solution is added in mixing, and 50min is stirred under the conditions of 25rpm and is mixed, wet product is obtained；
(3) wet product and water are placed in the wet processing of stirrer for mixing water inlet second, obtaining moisture content is 30%
It is granulated material, gained granulation material is added in rotary pelleting machine and is granulated, wet grain is obtained；
(4) the wet grain is sent into boiling drier through conveyer belt and 45min is dried, wherein boiling drier
Temperature parameter are as follows: inlet air temperature is 110~120 DEG C, and spin manifold temperature is 60~65 DEG C, and leaving air temp is 50~55 DEG C, obtains salt
Mycin particle.
Reference examples 2
(1) 1000kg salinomycin powder and water are placed in colter mixer, stir 15min under the conditions of 25rpm, carry out the
One wettability treatment obtains the wet-milling that moisture content is 23%；
(2) 10kg dextrin is dissolved in 100kg water and obtains dextrin in aqueous solution, by the wet-milling and 50kg calcium lignosulfonate
Dextrin in aqueous solution is added in mixing, and 50min is stirred under the conditions of 25rpm and is mixed, wet product is obtained；
(3) wet product and water are placed in the wet processing of stirrer for mixing water inlet second, obtaining moisture content is 50%
It is granulated material, gained granulation material is added in rotary pelleting machine and is granulated, wet grain is obtained；
(4) the wet grain is sent into boiling drier through conveyer belt and 45min is dried, wherein boiling drier
Temperature parameter are as follows: inlet air temperature is 110~120 DEG C, and spin manifold temperature is 60~65 DEG C, and leaving air temp is 50~55 DEG C, obtains salt
Mycin particle.
Reference examples 3
(1) 1000kg salinomycin powder and water are placed in colter mixer, stir 15min under the conditions of 25rpm, carry out the
One wettability treatment obtains the wet-milling that moisture content is 16.7%；
(2) 30kg dextrin is dissolved in 100kg water and obtains dextrin in aqueous solution, the wet-milling and dextrin in aqueous solution are existed
50min is stirred under the conditions of 25rpm to be mixed, and wet product is obtained；
(3) wet product and water are placed in the wet processing of stirrer for mixing water inlet second, obtaining moisture content is 40%
It is granulated material, gained granulation material is added in rotary pelleting machine and is granulated, wet grain is obtained；
(4) the wet grain is sent into boiling drier through conveyer belt and 45min is dried, wherein boiling drier
Temperature parameter are as follows: inlet air temperature is 110~120 DEG C, and spin manifold temperature is 60~65 DEG C, and leaving air temp is 50~55 DEG C, obtains salt
Mycin particle.
Reference examples 4
(1) 1000kg salinomycin powder and water are placed in colter mixer, stir 15min under the conditions of 25rpm, carry out the
One wettability treatment obtains the wet-milling that moisture content is 16.7%；
(2) wet-milling, 25kg sodium lignin sulfonate and 25kg calcium lignosulfonate are stirred under the conditions of 25rpm
50min is mixed, and wet product is obtained；
(3) wet product and water are placed in the wet processing of stirrer for mixing water inlet second, obtaining moisture content is 45%
It is granulated material, gained granulation material is added in rotary pelleting machine and is granulated, wet grain is obtained；
(4) the wet grain is sent into boiling drier through conveyer belt and 45min is dried, wherein boiling drier
Temperature parameter are as follows: inlet air temperature is 110~120 DEG C, and spin manifold temperature is 60~65 DEG C, and leaving air temp is 50~55 DEG C, obtains salt
Mycin particle.
Reference examples 5
(1) 1000kg salinomycin powder and water are placed in colter mixer, stir 15min under the conditions of 25rpm, carry out the
One wettability treatment obtains the wet-milling that moisture content is 23%；
(2) 8kg dextrin is dissolved in 100kg water and obtains dextrin in aqueous solution, by the wet-milling, 26kg sodium lignin sulfonate and
The mixing of 26kg calcium lignosulfonate, is added dextrin in aqueous solution, and 50min is stirred under the conditions of 25rpm and is mixed, wet product is obtained；
(3) wet product and water are placed in the wet processing of stirrer for mixing water inlet second, obtaining moisture content is 45%
It is granulated material, gained granulation material is added in rotary pelleting machine and is granulated, wet grain is obtained；
(4) the wet grain is sent into boiling drier through conveyer belt and 45min is dried, wherein boiling drier
Temperature parameter are as follows: inlet air temperature is 130 DEG C, and spin manifold temperature is 70 DEG C, and leaving air temp is 60 DEG C, obtains salinomycin particle.
Reference examples 6
(1) 1000kg salinomycin powder and water are placed in colter mixer, stir 15min under the conditions of 25rpm, carry out the
One wettability treatment obtains the wet-milling that moisture content is 23%；
(2) 40kg dextrin is dissolved in 100kg water and obtains dextrin in aqueous solution, by the wet-milling, 10kg sodium lignin sulfonate
It is mixed with 10kg calcium lignosulfonate, dextrin in aqueous solution is added, 50min is stirred under the conditions of 25rpm and is mixed, is obtained wet
Product；
(3) wet product and water are placed in the wet processing of stirrer for mixing water inlet second, obtaining moisture content is 45%
It is granulated material, gained granulation material is added in rotary pelleting machine and is granulated, wet grain is obtained；
(4) the wet grain is sent into boiling drier through conveyer belt and 45min is dried, wherein boiling drier
Temperature parameter are as follows: inlet air temperature is 110~120 DEG C, and spin manifold temperature is 60~65 DEG C, and leaving air temp is 50~55 DEG C, obtains salt
Mycin particle.
Reference examples 7
(1) 1000kg salinomycin powder and water are placed in colter mixer, stir 15min under the conditions of 25rpm, carry out the
One wettability treatment obtains the wet-milling that moisture content is 23%；
(2) 60kg sucrose is dissolved in 100kg water and obtains sucrose solution, by the wet-milling and sucrose solution, in 25rpm item
50min is stirred under part to be mixed, and wet product is obtained；
(3) wet product and water are placed in the wet processing of stirrer for mixing water inlet second, obtaining moisture content is 45%
It is granulated material, gained granulation material is added in rotary pelleting machine and is granulated, wet grain is obtained；
(4) the wet grain is sent into boiling drier through conveyer belt and 45min is dried, wherein boiling drier
Temperature parameter are as follows: inlet air temperature is 110~120 DEG C, and spin manifold temperature is 60~65 DEG C, and leaving air temp is 50~55 DEG C, obtains salt
Mycin particle.
Reference examples 8
(1) 1000kg salinomycin powder and water are placed in colter mixer, stir 15min under the conditions of 25rpm, carry out the
One wettability treatment obtains the wet-milling that moisture content is 20%；
(2) 10kg dextrin is dissolved in 100kg water and obtains dextrin in aqueous solution, by the wet-milling, 25kg sodium lignin sulfonate
It is mixed with 25kg calcium lignosulfonate, dextrin in aqueous solution is added, 50min is stirred under the conditions of 25rpm and is mixed, is obtained wet
Product；
(3) wet product and water are placed in the wet processing of stirrer for mixing water inlet second, obtaining moisture content is 45%
It is granulated material, gained granulation material is added in rotary pelleting machine and is granulated, wet grain is obtained；
(4) the wet grain is sent into boiling drier through conveyer belt and 45min is dried, wherein boiling drier
Temperature parameter are as follows: inlet air temperature is 95~105 DEG C, and spin manifold temperature is 50~55 DEG C, and leaving air temp is 40~45 DEG C, and it is mould to obtain salt
Crude granule.
Reference examples 9
(1) 1000kg salinomycin powder and water are placed in colter mixer, stir 15min under the conditions of 25rpm, carry out the
One wettability treatment obtains the wet-milling that moisture content is 23%；
(2) 10kg dextrin is dissolved in 100kg water and obtains dextrin in aqueous solution, by the wet-milling, 25kg sodium lignin sulfonate
It is mixed with 25kg calcium lignosulfonate, dextrin in aqueous solution is added, 50min is stirred under the conditions of 25rpm and is mixed, is obtained wet
Product；
(3) wet product and water are placed in the wet processing of stirrer for mixing water inlet second, obtaining moisture content is 45%
It is granulated material, gained granulation material is added in rotary pelleting machine and is granulated, wet grain is obtained；
(4) the wet grain is sent into boiling drier through conveyer belt and 45min is dried, wherein boiling drier
Temperature parameter are as follows: inlet air temperature is 150~160 DEG C, and spin manifold temperature is 70~75 DEG C, and leaving air temp is 70~75 DEG C, obtains salt
Mycin particle.
Test case
Salinomycin particle prepared by Examples 1 to 4 and reference examples 1~9 is crossed into 80 meshes, measurement sieves upper particle and accounts for test specimens
The percentage of product gross mass, i.e. granulating rate, and its particle uniformity is observed, test result is as shown in table 1.
1 granulating rate of table and particle uniformity test result
As shown in Table 1, reference examples 1~2 it is found that after the first wettability treatment and/or the second wettability treatment material moisture content
Too low, material is too dry, and the grain produced is not full enough, and compared with easy fracture, thus granulating rate is lower, and uniform granularity is not so good；The
The moisture content of material is excessively high after one wettability treatment and/or the second wettability treatment, and material is wetter, not only affects granulation speed, and
And the grain produced is easy to bond again, thus bulky grain is relatively more in the obtained salinomycin particle of drying, particle uniformity is poor.It is right
3~4 it is found that exclusive use lignosulfonates or dextrin cause viscosity poor, without included and outsourcing as adhesive as usual
Effect, thus cause granulating rate lower, and particle uniformity is poor；Reference examples 5 know lignosulfonates and paste in adhesive
The mass ratio of essence is excessive to will cause that viscosity is bigger than normal, and the grain produced is not easy to burst apart during the drying process, causes bulky grain more；Control
Example 6 causes cohesive force inadequate, and then lead to granulating rate it is found that the mass ratio of lignosulfonates and dextrin is too small in adhesive
It is lower, and particle uniformity is poor.For reference examples 7 it is found that using sucrose as adhesive, particle is irregular, and uniformity is not so good, granulating
Rate is lower；Reference examples 8~9 cause paste burnt, make adhesive failure or do not dry to cause grain it is found that drying temperature is too high or too low
Degree is not hard, also has agglomeration and generates, thus granulating rate is lower, and particle uniformity is not so good.And the present invention passes through control first
The moisture content of material after wettability treatment and/or the second wettability treatment, with the use of the lignosulfonates and dextrin of special ratios
Mixture controls dry actual temp parameter as bonding agent, substantially increases granulating rate, and particle uniformity is good.
The above is only a preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, various improvements and modifications may be made without departing from the principle of the present invention, these improvements and modifications are also answered
It is considered as protection scope of the present invention.
Claims (10)
1. a kind of preparation method of salinomycin particle, which comprises the following steps:
Salinomycin fine powder and water are mixed and carry out the first wettability treatment, obtains wet-milling；
The wet-milling and adhesive are mixed, wet product is obtained；
The wet product and water are mixed and are granulated after carrying out the second wettability treatment, wet grain is obtained；
The wet grain is dried, salinomycin particle is obtained.
2. preparation method according to claim 1, which is characterized in that the moisture content of the wet-milling is 16~26%.
3. preparation method according to claim 1, which is characterized in that the mass ratio of the salinomycin fine powder and adhesive is
1:(0.04~0.09).
4. preparation method according to claim 1, which is characterized in that described adhesive is lignosulfonates and dextrin
Mixture；The mass ratio of the lignosulfonates and dextrin is (1~6): 1.
5. preparation method according to claim 4, which is characterized in that the dextrin include maltodextrin, dry dextrin and
One or more of cyclodextrin.
6. preparation method according to claim 1, which is characterized in that it is described first wetting pretreatment under agitation into
Row, the speed of the stirring are 20~30rpm, and the time is 10~15min.
7. preparation method according to claim 1, which is characterized in that the wet-milling and adhesive mixing are under agitation
It carries out, the speed of the stirring is 20~30rpm, and the time is 30~60min.
8. preparation method according to claim 1, which is characterized in that resulting material is aqueous after second wettability treatment
Rate is 32~48%.
9. preparation method according to claim 1, which is characterized in that the temperature of the drying is 50~140 DEG C, described dry
The dry time is 30~60min.
10. according to claim 1 or preparation method described in 9, which is characterized in that the drying carries out in boiling drier；
The inlet air temperature for controlling the boiling drier is 110~140 DEG C, and spin manifold temperature is 60~65 DEG C, and leaving air temp is 50~65
℃。
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0731383A (en) * | 1993-07-23 | 1995-02-03 | Kaken Pharmaceut Co Ltd | Granular preparation for adding to feed |
| CN101926776A (en) * | 2010-08-13 | 2010-12-29 | 清远容大生物工程有限公司 | Salinomycin sodium suspension as well as preparation method and application thereof |
| CN108309953A (en) * | 2018-03-30 | 2018-07-24 | 内蒙古拜克生物有限公司 | A kind of production method of salinomycin microcapsule granule |
-
2019
- 2019-04-28 CN CN201910349554.5A patent/CN110025582B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0731383A (en) * | 1993-07-23 | 1995-02-03 | Kaken Pharmaceut Co Ltd | Granular preparation for adding to feed |
| CN101926776A (en) * | 2010-08-13 | 2010-12-29 | 清远容大生物工程有限公司 | Salinomycin sodium suspension as well as preparation method and application thereof |
| CN108309953A (en) * | 2018-03-30 | 2018-07-24 | 内蒙古拜克生物有限公司 | A kind of production method of salinomycin microcapsule granule |
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