CN102327232A - Preparation method of granular premixing agent - Google Patents
Preparation method of granular premixing agent Download PDFInfo
- Publication number
- CN102327232A CN102327232A CN201110142247A CN201110142247A CN102327232A CN 102327232 A CN102327232 A CN 102327232A CN 201110142247 A CN201110142247 A CN 201110142247A CN 201110142247 A CN201110142247 A CN 201110142247A CN 102327232 A CN102327232 A CN 102327232A
- Authority
- CN
- China
- Prior art keywords
- preparing
- sieve
- drying
- screening
- wet
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000002360 preparation method Methods 0.000 title abstract description 7
- 239000008187 granular material Substances 0.000 claims abstract description 53
- 238000000034 method Methods 0.000 claims abstract description 41
- 238000001035 drying Methods 0.000 claims abstract description 28
- 238000012216 screening Methods 0.000 claims abstract description 24
- 239000000843 powder Substances 0.000 claims abstract description 18
- 238000002156 mixing Methods 0.000 claims description 35
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 20
- 239000004744 fabric Substances 0.000 claims description 19
- 239000002245 particle Substances 0.000 claims description 17
- 238000012856 packing Methods 0.000 claims description 11
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 8
- 239000003814 drug Substances 0.000 claims description 7
- 239000000463 material Substances 0.000 claims description 7
- 239000011230 binding agent Substances 0.000 claims description 6
- 229940079593 drug Drugs 0.000 claims description 6
- 229920000881 Modified starch Polymers 0.000 claims description 5
- 239000007921 spray Substances 0.000 claims description 5
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 4
- 229910021536 Zeolite Inorganic materials 0.000 claims description 2
- 238000009835 boiling Methods 0.000 claims description 2
- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 claims description 2
- 238000005303 weighing Methods 0.000 claims description 2
- 239000010457 zeolite Substances 0.000 claims description 2
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 claims 2
- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 claims 1
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 1
- 239000001856 Ethyl cellulose Substances 0.000 claims 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims 1
- 108010010803 Gelatin Proteins 0.000 claims 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 1
- 229930195725 Mannitol Natural products 0.000 claims 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-L Phosphate ion(2-) Chemical compound OP([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-L 0.000 claims 1
- 239000004372 Polyvinyl alcohol Substances 0.000 claims 1
- 229920002472 Starch Polymers 0.000 claims 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims 1
- 239000001768 carboxy methyl cellulose Substances 0.000 claims 1
- 235000019325 ethyl cellulose Nutrition 0.000 claims 1
- 229920001249 ethyl cellulose Polymers 0.000 claims 1
- 229960004667 ethyl cellulose Drugs 0.000 claims 1
- 229920000159 gelatin Polymers 0.000 claims 1
- 239000008273 gelatin Substances 0.000 claims 1
- 235000019322 gelatine Nutrition 0.000 claims 1
- 235000011852 gelatine desserts Nutrition 0.000 claims 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 1
- 239000000594 mannitol Substances 0.000 claims 1
- 235000010355 mannitol Nutrition 0.000 claims 1
- 229920000609 methyl cellulose Polymers 0.000 claims 1
- 239000001923 methylcellulose Substances 0.000 claims 1
- 229960002900 methylcellulose Drugs 0.000 claims 1
- 235000010981 methylcellulose Nutrition 0.000 claims 1
- 229940016286 microcrystalline cellulose Drugs 0.000 claims 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims 1
- 239000008108 microcrystalline cellulose Substances 0.000 claims 1
- 238000004806 packaging method and process Methods 0.000 claims 1
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 1
- 235000019422 polyvinyl alcohol Nutrition 0.000 claims 1
- 229920001289 polyvinyl ether Polymers 0.000 claims 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 1
- 235000010408 potassium alginate Nutrition 0.000 claims 1
- 239000000737 potassium alginate Substances 0.000 claims 1
- MZYRDLHIWXQJCQ-YZOKENDUSA-L potassium alginate Chemical compound [K+].[K+].O1[C@@H](C([O-])=O)[C@@H](OC)[C@H](O)[C@H](O)[C@@H]1O[C@@H]1[C@@H](C([O-])=O)O[C@@H](O)[C@@H](O)[C@H]1O MZYRDLHIWXQJCQ-YZOKENDUSA-L 0.000 claims 1
- 235000010413 sodium alginate Nutrition 0.000 claims 1
- 239000000661 sodium alginate Substances 0.000 claims 1
- 229940005550 sodium alginate Drugs 0.000 claims 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims 1
- 239000008107 starch Substances 0.000 claims 1
- 235000019698 starch Nutrition 0.000 claims 1
- 238000003756 stirring Methods 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 abstract description 20
- 238000004519 manufacturing process Methods 0.000 abstract description 16
- 230000008569 process Effects 0.000 abstract description 13
- 239000000428 dust Substances 0.000 abstract description 5
- 230000000903 blocking effect Effects 0.000 abstract description 4
- 238000005265 energy consumption Methods 0.000 abstract description 4
- 230000008901 benefit Effects 0.000 abstract description 2
- 238000005516 engineering process Methods 0.000 description 11
- 238000005469 granulation Methods 0.000 description 10
- 230000003179 granulation Effects 0.000 description 10
- BXHCJLRTXPHUGH-UHFFFAOYSA-N 2-oxo-1h-pyridine-4-carboxylic acid Chemical compound OC(=O)C=1C=CNC(=O)C=1 BXHCJLRTXPHUGH-UHFFFAOYSA-N 0.000 description 9
- 238000007664 blowing Methods 0.000 description 7
- 230000014759 maintenance of location Effects 0.000 description 7
- 238000005070 sampling Methods 0.000 description 5
- 239000000203 mixture Substances 0.000 description 4
- 230000008859 change Effects 0.000 description 3
- 238000012797 qualification Methods 0.000 description 3
- 238000011084 recovery Methods 0.000 description 3
- ITCAUAYQCALGGV-UHFFFAOYSA-M sodium;1,4a-dimethyl-7-propan-2-yl-2,3,4,4b,5,6,10,10a-octahydrophenanthrene-1-carboxylate Chemical compound [Na+].C12CCC(C(C)C)=CC2=CCC2C1(C)CCCC2(C)C([O-])=O ITCAUAYQCALGGV-UHFFFAOYSA-M 0.000 description 3
- 238000010998 test method Methods 0.000 description 3
- 238000001514 detection method Methods 0.000 description 2
- 238000001125 extrusion Methods 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000005453 pelletization Methods 0.000 description 2
- 239000011148 porous material Substances 0.000 description 2
- 230000002269 spontaneous effect Effects 0.000 description 2
- RPABDKTXMKOGKI-OYTUFZPASA-N 6-methyl-n-[2-[(2s,5s,8s,11s,14s,17s,20s,23s)-8,11,14,20-tetrakis(2-aminoethyl)-5-[(1r)-1-hydroxyethyl]-17,23-bis(2-methylpropyl)-3,6,9,12,15,18,21,24-octaoxo-1,4,7,10,13,16,19,22-octazacyclotetracos-2-yl]ethyl]octanamide Chemical compound CCC(C)CCCCC(=O)NCC[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H]([C@@H](C)O)NC1=O RPABDKTXMKOGKI-OYTUFZPASA-N 0.000 description 1
- 108010078777 Colistin Proteins 0.000 description 1
- FPTCMHOCGKKRGQ-WYOWUDGCSA-N Multhiomycin Natural products CC=C1NC(=O)[C@@H](NC(=O)c2csc(n2)c3cc(O)c(nc3c4csc(n4)[C@H]5CSC(=O)c6[nH]c7cccc(COC(=O)[C@@H](O)C[C@H](NC(=O)c8csc1n8)c9nc(cs9)C(=O)N5)c7c6C)c%10nc(cs%10)C(=O)N[C@@H](C)C(=O)N)[C@H](C)O FPTCMHOCGKKRGQ-WYOWUDGCSA-N 0.000 description 1
- 101800003864 Nosiheptide Proteins 0.000 description 1
- 238000000889 atomisation Methods 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000013467 fragmentation Methods 0.000 description 1
- 238000006062 fragmentation reaction Methods 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- RWVUEZAROXKXRT-VQLSFVLHSA-N maduramicin Chemical compound O1[C@@H](C)[C@H](OC)[C@@H](OC)C[C@H]1O[C@@H]1[C@H]([C@@]2(C)O[C@H](CC2)[C@@]2(C)O[C@]3(O[C@@H]([C@H](C)[C@@H](O)C3)[C@@H](C)[C@H]3[C@@H]([C@@H](OC)[C@H](C)[C@@](O)(CC(O)=O)O3)OC)CC2)O[C@@H]([C@@H]2[C@H](C[C@@H](C)[C@@](C)(O)O2)C)C1 RWVUEZAROXKXRT-VQLSFVLHSA-N 0.000 description 1
- 229950006915 maduramicin Drugs 0.000 description 1
- MQWDKYHFGBWGQZ-JQTJYXGUSA-N nosiheptide Chemical compound N([C@H](C(=O)N\C(C=1SC=C(N=1)C(=O)N[C@@H]1CC(O)C(=O)OCC=2C=CC=C3NC(=C(C3=2)C)C(=O)SC[C@H](NC(=O)C=2N=C1SC=2)C=1SC=C(N=1)C1=N2)=C/C)[C@@H](C)O)C(=O)C(N=3)=CSC=3C1=CC(=O)\C2=C1/NC(C(=O)NC(=C)C(N)=O)=CS1 MQWDKYHFGBWGQZ-JQTJYXGUSA-N 0.000 description 1
- 229950006423 nosiheptide Drugs 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000001141 propulsive effect Effects 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- 238000010008 shearing Methods 0.000 description 1
- 229920002379 silicone rubber Polymers 0.000 description 1
- 239000004945 silicone rubber Substances 0.000 description 1
- 238000004088 simulation Methods 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid Substances OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Fodder In General (AREA)
- Detergent Compositions (AREA)
Abstract
The invention relates to a preparation method of a granular premixing agent, which is different from the conventional process in the aspects of improving the mixed granulating process and the preparation process, firstly screening with a screen after granulating and then drying screening-qualified products. The invention solves the problems of low primary yield or blocking of the screen net due to whole granules, breaking and frequent replacement of the screen net in the traditional process, and has the advantages of reducing large granules and fine powder, increasing the primary yield of products by 10-30 percent, reducing rework loss and production energy consumption, increasing finished product yield by 2-10 percent compared with that of the traditional process, relatively improving equipment utilization rate and production capacity, reducing production cost by 5-30 percent, being less in dust in the production process, and improving operation environment of workers, thereby being a cleaner production process of the premixing agent.
Description
Technical field
The present invention relates to a kind of method for preparing of pre-mixing agent, particularly relate to a kind of method for preparing of graininess pre-mixing agent.
Background technology
Pre-mixing agent (Premix) means the Powdered or granular formulations that medicine and suitable substrate uniform mixing are processed.Pre-mixing agent passes through feedstuff with certain drug level administration.The graininess pre-mixing agent has following characteristics with respect to the powdery pre-mixing agent: 1. good fluidity, and prevented from caking, conglomeration are prone to and the feedstuff mix homogeneously; Do not have dust when 2. using, improve operating environment.Because of above-mentioned advantage, the graininess pre-mixing agent constantly obtains promoting, and progressively replaces the powdery pre-mixing agent.
At present, graininess pre-mixing agent preparation technology method mainly contains following two kinds:
The technological process of first kind method is: mixing, granulation, drying, granulate, total mixed, packing, and this process route is a conventional process flow; Like the disclosed denomination of invention of Chinese patent document CN 101327314A is " nosiheptide-sulfuric acid colimycin premix and preparation thereof and method for using "; The shortcoming of this technology is that the granulation terminal point is difficult to control; Fine powder was many when the granulation time, short granulating was insufficient, and granulation time length is prone to the granule conglomeration; The back convection drying of granulating, accepted product percentage only 50～70%, dry back granulate can improve accepted product percentage, but the dry product granulate produces a large amount of dust, and operating environment is poor, and yield reduces.This technology product yield is merely 85-90%.
The technological process of second class methods is: wet-mixed granulation, granulate, drying, screening, packing.This technology is to adopt more process in recent years, is that " method for preparing of maduramicin ammonium premix ", the disclosed denomination of invention of patent documentation CN 101869188A are " method for preparing of Nosiheptide premixed agent " or the like like the disclosed denomination of invention of patent documentation CN 101879142A.This type of process is after granulation, to have increased granulate; Overcome the shortcoming of first kind of technology, improved product percent of pass, but owing to through the wet granular after the wet mixing pelletizer granulation certain viscosity is arranged; Wet granular very easily stops up screen cloth during granulate; Cause sieve breakage and frequent change, cause utilization rate of equipment and installations, production capacity seriously to descend, energy consumption and production cost significantly increase.
Summary of the invention
The technical problem that the present invention will solve provides a kind of method for preparing of graininess pre-mixing agent, and this method first-time qualification rate and product yield are high, and it is few to produce dust, and equipment efficiency of usage and production capacity are high, and production cost is low, is a kind of process for cleanly preparing.
For solving the problems of the technologies described above, the technical scheme that the present invention adopts is:
A kind of method for preparing of graininess pre-mixing agent may further comprise the steps:
(1) wet-mixed is granulated: with powdered medication, binding agent and carrier weighing, put in the wet mixing pelletizer, mixed 0.5～4 minute with 2000～2900r/min mixing rotating speed, make mix homogeneously; Under mixer high-speed stirred, shearing; The water that mixes gross weight 10～20% is at the uniform velocity joined in the wet mixing pelletizer with spray pattern, and adding the water time is 1～10 minute, adds water and finishes and continue to granulate 2～15 minutes; When powder all becomes granule; Granulate and finish, the pelletization scalable is mixed and the cutting rotating speed, adjustment granulation speed and time; The addition of said powdered medication is according to the decision of product content standard, and the binding agent addition is 1～5% of a mixed material gross weight;
(2) screening: with step (1) gained wet granular, sieve, qualified granule gets into drying process, and regrading after a small amount of bulky grain fragmentation of mistake screen cloth makes whole screenings qualified;
(3) drying: the wet granular that step (2) is obtained carries out ebullated bed or fluid bed drying, and EAT is 90～140 ℃ when dry, and leaving air temp is 30～100 ℃;
(4) screening, packing: the dried particles that step (3) is obtained sieves, and qualified granule sampling detects, packing.Sieve behind the bulky grain granulate, the certified products packing, or bulky grain is directly pulverized the back granulate again by said procedure with the screening fine powder.
Pre-mixing agent finished particle particle size range according to the invention is 24 orders～100 orders.
The fineness requirement of the various mixed materials described in the above-mentioned steps (1) is all through 60 orders, to guarantee mix homogeneously; Said to add the water time be 1～10 minute, and adding the water mode is that atomization adds; The said granulation time is 2～15 minutes.
In the above-mentioned steps (2) in the horizontal air-flow sieve of used screening plant, vibrosieve or the vibration and sway sieve any one.Horizontal air-flow sieve principle is that wet granular passes through helical feed and air-flow mixes, atomizing gets in the net tube, makes material receive centrifugal force and whirlwind propulsive force simultaneously through wind wheel blade in the net tube, thereby forces wet granular to spray net, reaches the screening purpose.This screening plant screen cloth receives washing away of whirlwind, and can be automatically clear net is difficult for stifled screen cloth, simultaneously caking materials is had broken function again.
Vibrosieve provides exciting force through vibrating motor, and the wet granular of false conglomeration is broken under exciting force, and by passing through screen cloth after certain path profile, screen cloth is installed elastic ball with the sieve compartment, constantly beats screen cloth, avoids sieve pore blockade.
Vibration and sway sieve drives through the low speed V-shape belt, and the artificial screening of simulation makes wet granular on screen cloth, be level and throwing three-dimensional tumbling motion, and false caking is broken at the volley, and from the center to the outer rim homodisperse, constantly pass through screen cloth; Screen cloth is installed efficient clear net arrangement such as elastic silicone rubber ball, ultrasound wave with the sieve compartment, and constantly the rapping screen cloth is avoided sieve pore blockade.
Used drying equipment can be any one in boiled bed drying machine, HighefficientFluidbeddrier, Vibratingfluidbeddrier or the horizontal boiling bed dryer in the above-mentioned steps (3).
Dressing sieve extension set described in the above-mentioned steps (4) is air-flow sieve, vibrosieve or vibration and sway sieve, and the upper strata screen cloth is that 24 orders, lower screen are 100 orders, can adjust
according to finish fineness.
The present invention has actively useful effect:
1. the present invention has improved the wet-mixed granulating process, has improved production procedure.Compare with traditional handicraft one, the product first-time qualification rate improves 10～30%, reduces bulky grain and fine powder, reduces do over again loss and energy consumption, and product yield improves 2～10% than traditional handicraft, and production cost reduces by 5～30%, and production capacity promotes relatively; The dust that production process produces is few, has improved workman's operating environment, is a kind of pre-mixing agent production technology of cleaning.
2. compare with traditional handicraft two, technology of the present invention has solved screen plugging, damaged, the frequent change screen cloth problem of granulate in the traditional handicraft, and equipment efficiency of usage and production capacity improve 10～30%, and energy consumption reduces on year-on-year basis, and production cost reduces by 5～20%.
The specific embodiment
Following examples have been merely and have further specified the present invention, do not limit content of the present invention.
One: three kind of different process method of embodiment prepares the contrast test of 1% maduramicin ammonium graininess pre-mixing agent
(1) traditional handicraft one preparation test procedure:
(1) wet-mixed is granulated: with 1.6kg (pure) maduramicin ammonium, 3kg pre-gelatinized starch, 145kg calcium carbonate, drop in the wet mixing pelletizer, mixed 4 minutes; The spontaneous current add mode adds 18kg water, adds 1.5 minutes water time; Continue to granulate 16 minutes, sampling detects qualified granule and accounts for 40%, and fine powder accounts for 60%; Continue to granulate 1 minute, qualified granule accounts for 58%, and bulky grain accounts for 42% (inhomogeneous because of adding water, bulky grain is a full particle, and hardness is big, is difficult for broken), granulates and finishes blowing;
(2) drying: the wet granular that step (2) is obtained carries out drying, and the qualified granule of sampling Detection dry product accounts for 61%, and bulky grain accounts for 36%, and fine powder accounts for 3%.
(3) granulate: dry product is carried out granulate with pelletizing machine, and cross 24 orders, 100 mesh sieves, get qualified granule 102kg, bulky grain 10kg, fine powder 32kg.This batch of accepted product percentage 68%.
(4) finished product detection Maduramicin content is 1.01%, 24 order retention rate, 0.2%, 100 order siftage 3.1%.
(2) traditional handicraft two preparation test procedures:
(1) wet-mixed is granulated: with 1.6kg (pure) maduramicin ammonium, 3kg pre-gelatinized starch, 145kg calcium carbonate, drop in the wet mixing pelletizer and mixed 4 minutes; The spontaneous current add mode adds 20kg water, adds 2 minutes water time; Continue to granulate 15 minutes, granulate and finish blowing; The qualified granule 68% of taking a sample to check, bulky grain account for 28% (inhomogeneous because of adding water, bulky grain is a full particle, and hardness is big, is difficult for broken), and fine powder accounts for 4%.
(2) granulate: with step (1) gained wet granular, carry out granulate, and cross 20 eye mesh screens through waving granulation machine.When granulate 1/2, screen cloth has slight stopping state, begins to have " extrusion " phenomenon, the granulate speed that slows down, when granulate to about 3/4 the time, screen cloth occurs damaged, " extrusion " phenomenon is serious, more renews screen cloth, and the leftover materials granulate is finished.This batch of 30 minutes granulate time, change screen cloth 5 minutes.
(3) drying: the wet granular that step (2) is obtained is at the boiling-bed drying inner drying.
(4) screening, packing: with the dried particles that step (3) obtains cross 24 orders, 100 orders revolve the sieve that shakes, must certified products 130kg, bulky grain 8.5kg, fine powder 8kg.This batch of accepted product percentage 86.6%, total recovery 97.6%.
(3) prepared test procedure of the present invention:
(1) wet-mixed is granulated: with 1.6kg (pure) maduramicin ammonium (all through 60 orders), 3kg pre-gelatinized starch, 145kg calcium carbonate, drop in the wet mixing pelletizer and mixed 2 minutes with 2900r/min mixing rotating speed; Atomizing type sprays into 18kg water, and water spraying time 4.5 minutes was granulated 10 minutes, when taking a sample to check all granulating, granulates and finishes blowing; Sampling detects qualified granule 65%, bulky grain 35% (be mostly false caking, external force promptly is separated into granule a little).
(2) screening: with step (1) gained wet granular, be transferred to air-flow through the air-flow conveying and sieve (20 order net), sieve qualified granule and collect the entering next procedure, sift out the 2.5kg bulky grain and carry out regrading, all through 24 eye mesh screens.15 minutes airflow screening time, screening the network blocking phenomenon do not occur smoothly.
(3) drying: the wet granular that step (2) is obtained is at efficient ebullated bed inner drying, and the control EAT is 100～140 ℃, and leaving air temp rises gradually, when reaching 60 ℃, stops heating, is cooled to 40 ℃, blowing.
(4) screening, packing: with the dried particles that step (3) obtains cross 24 orders, 100 orders revolve the sieve that shakes, must certified products 142kg, pack bulky grain 2.5kg, fine powder 5kg.
Accepted product percentage 94.6% of this product, total recovery 99.7%.
Product is detected, and maduramicin ammonium content is that 1.02%, 24 order retention rate is that 0.2%, 100 order retention rate is 1.6%, and detecting loss on drying is 1.2%, the equal conformance with standard requirement of above each item quality index.
The method for preparing (technology of the present invention) of two: 1% maduramicin ammonium graininess of embodiment pre-mixing agent, step is following:
(1) wet-mixed is granulated: with 1.6kg (pure) maduramicin ammonium (all through 60 orders), 3kg pre-gelatinized starch, 145kg zeolite powder, drop in the wet mixing pelletizer and mixed 2 minutes with 2700r/min mixing rotating speed; Atomizing type adds 20kg water, adds 6 minutes water time; Continue to granulate 9 minutes, when taking a sample to check all granulating, the end blowing of granulating; Sampling detects qualified granule 68%, bulky grain 32% (be mostly false caking, external force promptly is separated into granule a little).
(2) screening: with step (1) gained wet granular, sieve (20 order net), sieve qualified granule and collect the entering next procedure, sift out the 1.8kg bulky grain and carry out regrading, all through 20 eye mesh screens through air-flow.16 minutes this screening time, the network blocking phenomenon does not appear.
(3) drying: the wet granular that step (2) is obtained is at efficient ebullated bed inner drying, and the control EAT is 100～140 ℃, and leaving air temp rises gradually, when reaching 60 ℃, stops heating, is cooled to 40 ℃, blowing.
(4) screening, packing: with the dried particles that step (3) obtains cross 24 orders, 100 orders revolve the sieve that shakes, must certified products 142.5kg, pack bulky grain 0.8kg, fine powder 4.6kg.
Accepted product percentage 95.0% of this batch of product, product yield 98.6%.
Product is detected, and maduramicin ammonium content is that 1.01%, 24 order retention rate is that 0.1%, 100 order retention rate is 1.4%, and detecting loss on drying is 1.3%, the equal conformance with standard requirement of above each item quality index.
The method for preparing (technology of the present invention) of three: 10% Salinomycin Sodium graininess of embodiment pre-mixing agent, step is following:
(1) wet-mixed is granulated: with 15.9kg Salinomycin Sodium (pure, all through 60 orders), 2kgCMC, 132.1kg Semen Maydis powder, drop in the wet mixing pelletizer and mixed 2 minutes with 2500r/min mixing rotating speed; Add 20kg water with spray pattern, add 5 minutes water time; Continue to granulate 9 minutes, when taking a sample to check all granulating, the end blowing of granulating; Detect qualified granule and account for 72%, bulky grain accounts for 28% (be mostly false caking, external force promptly is separated into granule a little).
(2) screening: with step (1) gained wet granular, use air-flow to sieve (20 order net), sieve qualified granule and collect the entering next procedure, the 4.2kg bulky grain that sifts out carries out regrading, all passes through screen cloth.15 minutes this screening time, the network blocking phenomenon does not appear.
(3) drying: the wet granular that step (2) is obtained is at the vibrated fluidized bed inner drying, and the control EAT is 100～140 ℃, 65～80 ℃ of leaving air temps.
(4) screening, the packing: with the exsiccant dried granule of step (3) cross 24 orders, 100 orders revolve the sieve that shakes, sieve certified products 144kg, pack bulky grain 1.0kg, fine powder 3kg.
Product is detected, and Salinomycin Sodium content is that 10.3%, 24 order retention rate is that 0%, 100 order retention rate is 2.3%, loss on drying 3.6%, the equal conformance with standard requirement of above each item quality index.
This product first-time qualification rate 96%, total recovery 98.7%.
Though; The present invention has been done detailed description in the preceding text with general explanation and specific embodiments; But on its basis, can to some modifications of do or improvement (the appropriateness adjustment of technological parameter etc.), this will be apparent to those skilled in the art.Therefore, these modifications or the improvement on the basis of not departing from spirit of the present invention, made all belong to the scope that requirement of the present invention is protected.
Claims (8)
1. the method for preparing of a particle premix may further comprise the steps:
(1) wet-mixed is granulated: with powdered medication, binding agent and carrier weighing, put in the wet mixing pelletizer, mixed 0.5～4 minute with 2000～2900r/min mixing rotating speed, make mixing of materials even; Stir at mixer, shear down, the water that mixes gross weight 10～20% is at the uniform velocity joined in the wet mixing pelletizer with spray pattern, adding the water time is 1～10 minute, add water and finish and granulated 2～15 minutes, and when powder all becomes granule, the end of granulating; The addition of said powdered medication is according to the decision of product content standard, and the binding agent addition is 1～5% of a mixed material gross weight;
(2) screening: will go up step gained wet granular, and sieve, qualified wet granular gets into drying process, and bulky grain not over the net is broken or extremely qualified through regrading;
(3) drying: the qualified wet granular that step (2) is obtained carries out drying, and EAT is 90～140 ℃ when dry, and leaving air temp is 30～100 ℃;
(4) screening, packing: the dried particles that step (3) is obtained sieves, and qualified granule packaging sieves behind the bulky grain granulate that tails over, the certified products packing; Maybe the bulky grain that tails over directly being pulverized the back granulates by above-mentioned steps with the screening fine powder again.
2. the method for preparing of particle premix according to claim 1 is characterized in that, in said step (4), qualified grain graininess scope is 24 orders～100 orders.
3. the method for preparing of particle premix according to claim 1 is characterized in that, in said step (1), powdered medication, binding agent, carrier are all crossed 60 mesh sieves.
4. the method for preparing of particle premix according to claim 1; It is characterized in that said binding agent is at least a in pre-gelatinized starch, sodium carboxymethyl cellulose, gelatin, PVP, polyvinyl alcohol, polyvinylether, hydroxypropyl cellulose, potassium alginate, sodium alginate, ethyl cellulose, methylcellulose, the microcrystalline Cellulose.
5. the method for preparing of particle premix according to claim 1 is characterized in that, said carrier is at least a in calcium sulfate, calcium carbonate, starch, zeolite powder, mannitol, the dalcium biphosphate.
6. the method for preparing of particle premix according to claim 1 is characterized in that, sieve described in the step (2) is any one in vibrosieve, vibration and sway sieve or the horizontal air-flow sieve.
7. the method for preparing of particle premix according to claim 1 is characterized in that, drying equipment is any one in boiled bed drying machine, HighefficientFluidbeddrier, Vibratingfluidbeddrier, the horizontal boiling bed dryer in the step (3).
8. the method for preparing of particle premix according to claim 1 is characterized in that, the dressing sieve extension set is a vibrosieve described in the step (4), and the upper strata screen cloth is that 24 orders, lower screen are 100 orders.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011101422473A CN102327232B (en) | 2011-05-30 | 2011-05-30 | Preparation method of granular premixing agent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011101422473A CN102327232B (en) | 2011-05-30 | 2011-05-30 | Preparation method of granular premixing agent |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102327232A true CN102327232A (en) | 2012-01-25 |
| CN102327232B CN102327232B (en) | 2013-12-04 |
Family
ID=45479367
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011101422473A Active CN102327232B (en) | 2011-05-30 | 2011-05-30 | Preparation method of granular premixing agent |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102327232B (en) |
Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102806051A (en) * | 2012-08-15 | 2012-12-05 | 中南钻石股份有限公司 | Method for preparing raw material of pyrophyllite parts by mixing of fine pyrophyllite powder |
| CN103110515A (en) * | 2012-11-14 | 2013-05-22 | 江苏江山制药有限公司 | Glucosamine potassium sulfate particle production method |
| CN104940147A (en) * | 2015-06-29 | 2015-09-30 | 湖南泰谷生物科技股份有限公司 | Tilmicosin premix and preparation method thereof |
| CN106214658A (en) * | 2016-08-29 | 2016-12-14 | 北京英茂药业有限公司 | A kind of compound coating pre-mixing agent and preparation method thereof |
| CN106495811A (en) * | 2016-11-15 | 2017-03-15 | 天津水泥工业设计研究院有限公司 | A kind of rounded grain mineral fertilizer prilling and device |
| CN106721083A (en) * | 2016-12-21 | 2017-05-31 | 驻马店华中正大有限公司 | A kind of terramycin pre-mixing agent and preparation method thereof |
| CN106806132A (en) * | 2016-12-26 | 2017-06-09 | 北京长峰金鼎科技有限公司 | It is a kind of to be suitable to the method for granulating of viscous material |
| CN107156904A (en) * | 2017-06-16 | 2017-09-15 | 云南中烟工业有限责任公司 | Preparation method, the particle and the cigarette filter of a kind of cigarette filter tip root of kudzu vine particle |
| CN108013472A (en) * | 2017-11-24 | 2018-05-11 | 浙江百山祖生物科技有限公司 | A kind of production technology that edible fungi polysaccharide preparation is prepared using microencapsulation |
| CN109540725A (en) * | 2018-12-12 | 2019-03-29 | 江苏时代新能源科技有限公司 | Graphite powder detection method |
| CN109668757A (en) * | 2019-02-19 | 2019-04-23 | 桐城市畅润电力工程有限公司 | A kind of power equipment acquisition device |
| CN110585008A (en) * | 2019-08-07 | 2019-12-20 | 北京长峰金鼎科技有限公司 | Method for preparing granules by wet granulation method |
| CN112715759A (en) * | 2020-12-24 | 2021-04-30 | 上海信元宠物食品有限公司 | Anti-caking small-particle pet nutritional supplement and preparation method thereof |
| CN114027541A (en) * | 2021-11-02 | 2022-02-11 | 江苏大亚滤嘴材料有限公司 | Preparation method of tobacco fragrant granules |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1087026A (en) * | 1992-09-25 | 1994-05-25 | 武田药品工业株式会社 | The method of granulating of crude drug and solid preparation |
-
2011
- 2011-05-30 CN CN2011101422473A patent/CN102327232B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1087026A (en) * | 1992-09-25 | 1994-05-25 | 武田药品工业株式会社 | The method of granulating of crude drug and solid preparation |
Non-Patent Citations (3)
| Title |
|---|
| 张春美: "高效湿法混合制粒工艺探讨", 《科技资讯》, no. 4, 31 December 2005 (2005-12-31), pages 132 * |
| 程新梅: "喷雾制粒技术在中成药固体制剂中的应用", 《中国药业》, vol. 17, no. 12, 31 December 2008 (2008-12-31), pages 58 * |
| 郭建鹏等: "芪月降脂片制粒工艺的优化", 《延边大学医学学报》, vol. 26, no. 4, 31 December 2003 (2003-12-31), pages 243 - 245 * |
Cited By (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102806051B (en) * | 2012-08-15 | 2014-07-23 | 中南钻石有限公司 | Method for preparing raw material of pyrophyllite parts by mixing of fine pyrophyllite powder |
| CN102806051A (en) * | 2012-08-15 | 2012-12-05 | 中南钻石股份有限公司 | Method for preparing raw material of pyrophyllite parts by mixing of fine pyrophyllite powder |
| CN103110515A (en) * | 2012-11-14 | 2013-05-22 | 江苏江山制药有限公司 | Glucosamine potassium sulfate particle production method |
| CN104940147B (en) * | 2015-06-29 | 2018-06-19 | 湖南泰谷生物科技股份有限公司 | A kind of Tilmicosin pre-mixing agent and preparation method thereof |
| CN104940147A (en) * | 2015-06-29 | 2015-09-30 | 湖南泰谷生物科技股份有限公司 | Tilmicosin premix and preparation method thereof |
| CN106214658A (en) * | 2016-08-29 | 2016-12-14 | 北京英茂药业有限公司 | A kind of compound coating pre-mixing agent and preparation method thereof |
| CN106214658B (en) * | 2016-08-29 | 2019-05-03 | 北京英茂药业有限公司 | A kind of compound coating pre-mixing agent and preparation method thereof |
| CN106495811A (en) * | 2016-11-15 | 2017-03-15 | 天津水泥工业设计研究院有限公司 | A kind of rounded grain mineral fertilizer prilling and device |
| CN106721083A (en) * | 2016-12-21 | 2017-05-31 | 驻马店华中正大有限公司 | A kind of terramycin pre-mixing agent and preparation method thereof |
| CN106806132A (en) * | 2016-12-26 | 2017-06-09 | 北京长峰金鼎科技有限公司 | It is a kind of to be suitable to the method for granulating of viscous material |
| CN106806132B (en) * | 2016-12-26 | 2018-11-13 | 北京长峰金鼎科技有限公司 | A kind of method of granulating suitable for viscous material |
| CN107156904A (en) * | 2017-06-16 | 2017-09-15 | 云南中烟工业有限责任公司 | Preparation method, the particle and the cigarette filter of a kind of cigarette filter tip root of kudzu vine particle |
| CN108013472A (en) * | 2017-11-24 | 2018-05-11 | 浙江百山祖生物科技有限公司 | A kind of production technology that edible fungi polysaccharide preparation is prepared using microencapsulation |
| CN109540725A (en) * | 2018-12-12 | 2019-03-29 | 江苏时代新能源科技有限公司 | Graphite powder detection method |
| CN109540725B (en) * | 2018-12-12 | 2022-05-13 | 江苏时代新能源科技有限公司 | Graphite powder detection method |
| CN109668757A (en) * | 2019-02-19 | 2019-04-23 | 桐城市畅润电力工程有限公司 | A kind of power equipment acquisition device |
| CN110585008A (en) * | 2019-08-07 | 2019-12-20 | 北京长峰金鼎科技有限公司 | Method for preparing granules by wet granulation method |
| CN110585008B (en) * | 2019-08-07 | 2022-05-03 | 北京长峰金鼎科技有限公司 | Method for preparing granules by wet granulation method |
| CN112715759A (en) * | 2020-12-24 | 2021-04-30 | 上海信元宠物食品有限公司 | Anti-caking small-particle pet nutritional supplement and preparation method thereof |
| CN114027541A (en) * | 2021-11-02 | 2022-02-11 | 江苏大亚滤嘴材料有限公司 | Preparation method of tobacco fragrant granules |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102327232B (en) | 2013-12-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102327232B (en) | Preparation method of granular premixing agent | |
| CN106495811B (en) | Round particle mineral fertilizer granulation process and device | |
| CN1041735C (en) | Method and equipment for continuous granulation of high absorbent resin powder | |
| US20240017226A1 (en) | Spray Coated Fertilizer Composition | |
| GB2522490A (en) | Fertiliser product | |
| CN103071470B (en) | Absorbent pelletizing method | |
| CN106135644A (en) | The feedstuff production method of composite particles carrier | |
| CN207643427U (en) | Spoil slag dry powder and mortar production system | |
| CN102219232B (en) | Efficient compact spherical agglomerated particle of superfine boron powder and preparation method thereof | |
| CN110237771A (en) | A kind of preparation method of ball-type molecular sieve | |
| CN110218114A (en) | A kind of chemical fertilizer automation machining production line | |
| CN101390840B (en) | Production method of high-assay calcium ascorbate granules capable of directly being compressed | |
| CN101367537B (en) | Novel process for preparing spherical calcium chloride with spray of rotary kiln | |
| CN205435660U (en) | Wet granulation system of antibiotic granule | |
| RU2515293C1 (en) | Method of granulating particulates | |
| CN103071472A (en) | Flash-evaporation-dried molecular sieve pelletizing method | |
| CN214115389U (en) | Instant type organic fertilizer apparatus for producing | |
| CN103110588A (en) | Production method of vitamin B6 granules | |
| CN110585008B (en) | Method for preparing granules by wet granulation method | |
| CN202890425U (en) | Complete set of equipment for producing feed additive sodium butyrate and sustained-release preparation | |
| CN108102432A (en) | A kind of manufacturing method of active superfine calcium carbonate powder | |
| CN211921348U (en) | Mineral source soil conditioner granulation process system | |
| JPH11300192A (en) | Production of granulated particles | |
| JP2019163510A (en) | Granule, method for producing granule and method for producing sintered ore | |
| CN211913694U (en) | Mineral source soil conditioner granulation device |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: A preparation method of granular premix Effective date of registration: 20210308 Granted publication date: 20131204 Pledgee: Puyang branch of Bank of Zhengzhou Co.,Ltd. Pledgor: PUYANG HOTWAY PHARMACEUTICALS Co.,Ltd. Registration number: Y2021980001498 |
|
| PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20220526 Granted publication date: 20131204 Pledgee: Puyang branch of Bank of Zhengzhou Co.,Ltd. Pledgor: PUYANG HOTWAY PHARMACEUTICALS Co.,Ltd. Registration number: Y2021980001498 |
|
| PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: A preparation method of granular premix Effective date of registration: 20220608 Granted publication date: 20131204 Pledgee: Postal Savings Bank of China Limited by Share Ltd. Puyang branch Pledgor: PUYANG HOTWAY PHARMACEUTICALS Co.,Ltd. Registration number: Y2022980007339 |
|
| PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
| PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20230512 Granted publication date: 20131204 Pledgee: Postal Savings Bank of China Limited by Share Ltd. Puyang branch Pledgor: PUYANG HOTWAY PHARMACEUTICALS Co.,Ltd. Registration number: Y2022980007339 |
|
| PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Preparation method of a granular premix Effective date of registration: 20230517 Granted publication date: 20131204 Pledgee: Postal Savings Bank of China Limited by Share Ltd. Puyang branch Pledgor: PUYANG HOTWAY PHARMACEUTICALS Co.,Ltd. Registration number: Y2023980040671 |
|
| PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
| PC01 | Cancellation of the registration of the contract for pledge of patent right |
Granted publication date: 20131204 Pledgee: Postal Savings Bank of China Limited by Share Ltd. Puyang branch Pledgor: PUYANG HOTWAY PHARMACEUTICALS Co.,Ltd. Registration number: Y2023980040671 |