CN110013520B

CN110013520B - Pharmaceutical composition for treating chloasma

Info

Publication number: CN110013520B
Application number: CN201910222243.2A
Authority: CN
Inventors: 肖茜; 王超; 郭森; 王刚; 李春英; 高天文
Original assignee: Fourth Military Medical University FMMU
Current assignee: Fourth Military Medical University FMMU
Priority date: 2019-03-22
Filing date: 2019-03-22
Publication date: 2021-09-07
Anticipated expiration: 2039-03-22
Also published as: CN110013520A

Abstract

The invention belongs to the technical field of medicines, and relates to a pharmaceutical composition for treating chloasma, which comprises the following components in parts by weight: 5-25 parts of cortex mori radicis, 5-20 parts of ginkgo leaves, 5-30 parts of bletilla striata, 5-30 parts of radix paeoniae alba, 5-18 parts of radix angelicae, 5-25 parts of stiff silkworm, 5-25 parts of salvia miltiorrhiza, 10-40 parts of angelica sinensis, 5-20 parts of ligusticum wallichii, 5-25 parts of radix cyathulae, 5-25 parts of cortex albiziae and 5-20 parts of scutellaria baicalensis. The pharmaceutical composition for treating chloasma provided by the invention can regulate internal and external nourishment, regulate internal secretion, improve internal circulation and effectively remove chloasma.

Description

Pharmaceutical composition for treating chloasma

Technical Field

The invention belongs to the technical field of medicines, and relates to a pharmaceutical composition for treating chloasma.

Background

Chloasma is also called chloasma hepaticum, is yellowish brown pigmentation of the face, is distributed on the cheek in a more symmetrical butterfly shape, has unclear etiology, is mostly seen in women, and is caused by high estrogen level in blood in 10 percent of men, and in addition, the formation of the chloasma facialis is caused by the formation of mottle and pigmentation due to the obstruction of the fine circulation among histiocytes, the cell dissolution and death and the increase of melanin. It is known that facial chloasma spreads on the face rather than indirectly disfiguring, most women lose beauty and charm, become lack of confidence, are depressed and self-inferior, are unwilling to face friends, and the depressed mood over time causes further endocrine dysregulation and promotes more melanin to be accumulated on the face, so that the phenomenon that facial chloasma grows longer and more is caused, and the facial chloasma greatly influences the life and work of women. At present, the treatment method for chloasma comprises the following steps: 1. topical treatments, including topical medications, exfoliation, facial mask treatments, and laser or intense pulse light treatments; 2. systemic treatment: in order to promote hypopigmentation, vitamin C or tranexamic acid may be used, and these methods have disadvantages.

The traditional Chinese medicine considers that the causes of facial chloasma are as follows: insufficient essence and blood failing to nourish the face; or subcutaneous pigmentation due to stagnation of qi and blood, phlegm and blood stasis; or stagnation of qi due to depression of the liver, heat accumulation due to long-term stagnation, and yin and blood burn, which can lead to disharmony of qi and blood on face; or spleen deficiency with dampness, damp-heat accumulation, and steaming on the face; it is also considered that the treatment is related to Chong and ren meridians, which have the function of uterus ascending to the face, and the liver depression and blood stagnation impair the Chong and ren meridians, and qi and blood can not nourish the face, so the most effective way to treat chloasma is to regulate endocrine, eliminate internal deficiency, blood stasis, dampness and heat, and restore the human body function to a good physiological state, so the internal regulation and external treatment of traditional Chinese medicines is an important way to remove chloasma.

Disclosure of Invention

In view of the way of treating chloasma by traditional Chinese medicines provided in the background technology, the invention provides a pharmaceutical composition for treating chloasma from the perspective of traditional Chinese medicine, which regulates internal and external nourishment, regulates internal secretion, improves internal circulation and effectively removes chloasma.

The technical scheme adopted by the invention is as follows:

a pharmaceutical composition for treating chloasma is characterized in that: the pharmaceutical composition for treating chloasma comprises cortex mori radicis, folium ginkgo, bletilla striata, radix paeoniae alba, radix angelicae, stiff silkworm, radix salviae miltiorrhizae, angelica sinensis, ligusticum wallichii, radix cyathulae and cortex albiziae; the weight portions are respectively as follows: 5-25 parts of cortex mori radicis, 5-25 parts of ginkgo leaves, 5-30 parts of bletilla striata, 5-30 parts of radix paeoniae alba, 3-18 parts of radix angelicae, 5-25 parts of stiff silkworm, 5-25 parts of salvia miltiorrhiza, 10-40 parts of angelica sinensis, 5-25 parts of ligusticum wallichii, 5-25 parts of radix cyathulae and 5-25 parts of cortex albiziae.

The pharmaceutical composition for treating chloasma comprises the following components in parts by weight: 10-20 parts of cortex mori radicis, 8-20 parts of ginkgo leaves, 10-20 parts of bletilla striata, 10-20 parts of radix paeoniae alba, 5-15 parts of radix angelicae, 8-20 parts of stiff silkworm, 9-20 parts of salvia miltiorrhiza, 15-30 parts of angelica sinensis, 8-20 parts of ligusticum wallichii, 8-20 parts of radix cyathulae and 8-20 parts of cortex albiziae.

The pharmaceutical composition for treating chloasma comprises the following components in parts by weight: 12-18 parts of cortex mori radicis, 10-15 parts of ginkgo leaves, 12-18 parts of bletilla striata, 12-18 parts of radix paeoniae alba, 8-12 parts of radix angelicae, 12-18 parts of stiff silkworm, 12-18 parts of salvia miltiorrhiza, 18-25 parts of angelica sinensis, 10-15 parts of ligusticum wallichii, 10-15 parts of radix cyathulae and 10-15 parts of cortex albiziae.

The pharmaceutical composition for treating chloasma comprises the following components in parts by weight: 15 parts of cortex mori radicis, 12 parts of ginkgo leaves, 15 parts of bletilla striata, 15 parts of white paeony roots, 9 parts of angelica dahurica, 15 parts of stiff silkworms, 15 parts of salvia miltiorrhiza, 20 parts of angelica, 12 parts of ligusticum wallichii, 12 parts of medicinal cyathula roots and 12 parts of cortex albiziae.

The pharmaceutical composition for treating chloasma also comprises scutellaria; the weight portion of the scutellaria baicalensis is 2-20.

The weight portion of the scutellaria baicalensis is 5-15 portions.

The weight portion of the scutellaria baicalensis is 7-12 portions.

The weight portion of the scutellaria baicalensis is 9 portions.

The invention has the advantages that:

the pharmaceutical composition for treating chloasma provided by the invention adopts the mulberry bark, the ginkgo leaf and the bletilla striata as the monarch drugs; radix paeoniae alba, radix angelicae, stiff silkworm, radix salviae miltiorrhizae and angelica sinensis are used as ministers; rhizoma Ligustici Chuanxiong, radix Cyathulae and cortex Albizziae as adjuvants; the scutellaria baicalensis is used for ensuring that the plant composition is a pure traditional Chinese medicine plant, has the effects of warming and invigorating, promoting blood circulation to remove blood stasis and dispelling damp-heat, can regulate endocrine from the aspects of heart, liver, gallbladder, spleen, lung, stomach, kidney and intestine, improves the internal circulation of a human body, eliminates internal siltation, restores the function of the human body to a good physiological state and achieves the aim of dispelling chloasma from inside to outside.

Detailed Description

The invention will now be further described with reference to specific embodiments.

The pharmaceutical composition for treating chloasma comprises cortex mori radicis, folium ginkgo, bletilla striata, radix paeoniae alba, radix angelicae, stiff silkworm, salvia miltiorrhiza, angelica, ligusticum wallichii, radix cyathulae and cortex albiziae; the weight portions are respectively as follows: 5-25 parts of cortex mori radicis, 5-25 parts of ginkgo leaves, 5-30 parts of bletilla striata, 5-30 parts of radix paeoniae alba, 3-18 parts of radix angelicae, 5-25 parts of stiff silkworm, 5-25 parts of salvia miltiorrhiza, 10-40 parts of angelica sinensis, 5-25 parts of ligusticum wallichii, 5-25 parts of radix cyathulae and 5-25 parts of cortex albiziae. The pharmaceutical composition for treating chloasma comprises the following components in parts by weight: 10-20 parts of cortex mori radicis, 8-20 parts of ginkgo leaves, 10-20 parts of bletilla striata, 10-20 parts of radix paeoniae alba, 5-15 parts of radix angelicae, 8-20 parts of stiff silkworm, 9-20 parts of salvia miltiorrhiza, 15-30 parts of angelica sinensis, 8-20 parts of ligusticum wallichii, 8-20 parts of radix cyathulae and 8-20 parts of cortex albiziae. The pharmaceutical composition for treating chloasma comprises the following components in parts by weight: 12-18 parts of cortex mori radicis, 10-15 parts of ginkgo leaves, 12-18 parts of bletilla striata, 12-18 parts of radix paeoniae alba, 8-12 parts of radix angelicae, 12-18 parts of stiff silkworm, 12-18 parts of salvia miltiorrhiza, 18-25 parts of angelica sinensis, 10-15 parts of ligusticum wallichii, 10-15 parts of radix cyathulae and 10-15 parts of cortex albiziae. The pharmaceutical composition for treating chloasma comprises the following components in parts by weight: 15 parts of cortex mori radicis, 12 parts of ginkgo leaves, 15 parts of bletilla striata, 15 parts of white paeony roots, 9 parts of angelica dahurica, 15 parts of stiff silkworms, 15 parts of salvia miltiorrhiza, 20 parts of angelica, 12 parts of ligusticum wallichii, 12 parts of medicinal cyathula roots and 12 parts of cortex albiziae.

The pharmaceutical composition for treating chloasma also comprises scutellaria; the weight portion of the scutellaria baicalensis is 2-20. 5-15 parts of scutellaria baicalensis. 7-12 parts of scutellaria baicalensis. The weight portion of the baical skullcap root is 9 portions.

The traditional Chinese medicine plant composition adopted by the invention has the following curative effects:

white mulberry root-bark: sweet and pungent in flavor and cold in nature, entering lung meridian; has the effects of purging the lung, relieving asthma, inducing diuresis and relieving swelling; it is used for treating lung heat cough and asthma, watery fluid stopping lung, distention, dyspnea, edema, loempe, dysuresia, and edema of facial skin.

Ginkgo leaf: sweet and bitter, astringent and neutral; heart and lung meridian entered; has effects of promoting blood circulation, removing blood stasis, dredging collaterals, relieving pain, astringing lung, relieving asthma, eliminating turbid pathogen, and reducing blood lipid; can be used for treating blood stasis, obstruction of collaterals, thoracic obstruction, cardialgia, apoplexy, hemiplegia, cough with asthma due to lung deficiency, and hyperlipidemia.

Bletilla striata: bitter, sweet, astringent and slightly cold; entering lung, liver and stomach meridians; has effects of astringing, stopping bleeding, relieving swelling, and promoting granulation; can be used for treating hemoptysis, hematemesis, traumatic hemorrhage, pyocutaneous disease, toxic swelling, and chapped skin.

White peony root: bitter and sour taste, slightly cold in nature; enter liver, spleen and lung meridians; has effects in nourishing blood, regulating menstruation, astringing yin, arresting sweating, softening liver, relieving pain, and suppressing liver yang; it is commonly used for blood deficiency and chlorosis, irregular menstruation, spontaneous perspiration, night sweat, hypochondriac pain, abdominal pain, limb spasm and pain, headache and vertigo.

Radix angelicae: fragrant smell, pungent and slightly bitter taste and warm property; enter lung, spleen and stomach channels, and have the functions of dispelling diseases, removing dampness, expelling pus, promoting granulation, promoting blood circulation, relieving pain and the like by using the root as a medicine; it can be used for treating wind-cold type common cold, headache, rhinitis, toothache, leucorrhea with red and white discharge, pain, furuncle, and toxic swelling.

Stiff silkworm: salty and pungent taste, mild in nature; it enters liver, lung and stomach meridians; has the effects of calming endogenous wind, relieving spasm, dispelling pathogenic wind, relieving pain, eliminating phlegm, and resolving masses; it is commonly used for treating liver wind with phlegm, infantile convulsion, infantile convulsion, tetanus, apoplexy, wry mouth, wind-heat headache, conjunctival congestion, pharyngalgia, rubella pruritus, and parotitis.

Red sage root: bitter and slightly cold in taste; heart and liver meridian entered; has the effects of promoting blood circulation, removing blood stasis, dredging channels, relieving pain, clearing away heart-fire, relieving restlessness, cooling blood and eliminating carbuncle; can be used for treating thoracic obstruction, heart pain, abdominal pain, hypochondriac pain, abdominal mass, pain due to pyretic arthralgia, vexation, insomnia, menoxenia, dysmenorrhea, amenorrhea, and pyocutaneous disease with swelling and pain. The record in Qianjin Fang records that it is used for treating irregular menstruation, or before or after, more or less, antenatal abortion uneasiness, postpartum lochiorrhea, and cold and hot abortion: twelve red sage roots and twelve red sage roots, five liters of wine, three liters of wine, one liter of wine for warm taking and three liters of wine for one day; or decocting in water.

Chinese angelica: sweet and pungent taste and warm nature; it enters liver, heart and spleen meridians; has the functions of enriching blood, promoting blood circulation, regulating menstruation, relieving pain, moistening intestine and relaxing bowels. It is commonly used for treating blood deficiency, sallow complexion, giddiness, cardiopalmus, menoxenia, amenorrhea, dysmenorrhea, asthenia cold, abdominal pain, rheumatalgia, traumatic injury, carbuncle, cellulitis, pyocutaneous disease, constipation due to intestinal dryness, and blood circulation promoting and menstruation dredging with radix Angelicae sinensis, and can be used for treating amenorrhea, dysmenorrhea due to rheumatism, rheumatalgia, and traumatic injury.

Ligusticum wallichii: pungent and warm in taste; entering liver and gallbladder meridians; it is commonly used for promoting blood circulation and activating qi-flowing, dispelling pathogenic wind and relieving pain, rhizoma Ligustici Chuanxiong is pungent, warm, fragrant and dry, and can disperse and ascend to the vertex; enter the blood system and descend to reach the blood sea; promoting blood circulation and removing blood stasis, and is suitable for various diseases caused by blood stasis; it has good effect in dispelling pathogenic wind and relieving pain, and can be used for treating headache, rheumatalgia, etc. Xiren is that Chuan Xiong is a qi-flowing medicine in blood, but it has the functions of dispersing acrid, relieving depression, dredging and relieving pain.

Radix cyathulae: sweet, slightly bitter and neutral in nature; entering liver and kidney meridians; has the effects of removing blood stasis, dredging channels, promoting joint movement, and inducing diuresis for treating stranguria; can be used for treating amenorrhea, abdominal mass, retained afterbirth, traumatic injury, rheumatalgia, flaccidity of feet, spasm of tendons, and hematuria.

Silktree albizzia bark: sweet in taste and neutral in nature; entering heart and liver meridians; the main functional indications are as follows: resolving stagnation, regulating blood, calming heart, and eliminating carbuncle and swelling; it is indicated for restlessness of heart-mind, insomnia due to melancholy, pulmonary abscess, carbuncle, scrofula, fracture of tendons and bones, restlessness of heart-qi, insomnia and spasm of tendons and muscles.

Scutellaria baicalensis: bitter taste and cold nature; it enters lung, gallbladder, spleen, large intestine and small intestine meridians; has effects in clearing away heat, eliminating dampness, purging pathogenic fire, removing toxic substances, stopping bleeding, and preventing miscarriage; can be used for treating damp-warm syndrome, summer-heat dampness, chest distress, emesis, dampness and heat distention, dysentery, jaundice, cough due to lung heat, hyperpyrexia, polydipsia, hematemesis, carbuncle, swelling, sore, and threatened abortion.

Based on the efficacy of the plants, the composition is prepared according to different weight parts, and is specifically shown in table 1 and used for treating chloasma patients.

TABLE 1 compositions for treating chloasma

Therapeutic example 1

The patients: zhangyi, female, 31 years old, married, City white-collar, Shaanxi xi-an; symptoms are: chloasma around the tail of the eye has been seen for two years, and the color is light brown; spot-lightening cosmetic products are externally applied, but the effect is not ideal; the treatment is carried out at any time, chloasma is developed due to endocrine dyscrasia caused by mental stress and insomnia through diagnosis, any group of the above embodiments is selected, the composition is put into a casserole, three bowls of water are added, the mixture is decocted for two hours with medium fire, the decoction is taken orally, the decoction is taken once in the morning and at night, three treatment courses are taken, one treatment course is 7 days, and during the treatment course, alcohol drinking and pungency are avoided, and more vegetables and fruits are eaten; the repeated diagnosis shows that the face has no pain and itch, no adverse effect, smooth mood, sufficient sleep, obvious alleviation of symptoms and obvious lightening of the color of the chloasma, which indicates that the plant composition provided by the invention has an effect on treating the chloasma.

The patients: one, woman, 28 years old, single, free-job; symptoms are: chloasma is generated below eyes, on the nose side and around the corners of the mouth for three years, and the symmetry is good; the color is light brown and tends to be deepened; the mask, cream and capsule for removing freckles on the market are used, but the effect is not ideal; the chloasma caused by long-term endocrine dyscrasia due to drinking, drug abuse, irregular daily work and rest time and insomnia is diagnosed, any one group in the embodiment is selected, the composition is put into a casserole, three bowls of water are added, the mixture is decocted for two hours by medium fire, the decoction is taken orally, the medicine is taken twice a day, three treatment courses are taken, one treatment course is 7 days, the work and rest time is regular during the treatment period, drinking and spicy taste are avoided, and more vegetables and fruits are eaten; after the re-diagnosis, the sleep quality of the patient is improved, the mental state is good, no discomfort is caused to the face, the symptoms of chloasma are obviously lightened, the area of the chloasma is gradually reduced, and the effect of treating the chloasma is obvious.

Therapeutic example 3

The patients: some of the week, female, age 42, national enterprise office, mothers of two children; symptoms are: chloasma appears on the face for five years, and the color is brown; the patient has taken the capsule for treating chloasma for one year, but the effect is not obvious; the diagnosis shows that the family work pressure of the patient is high, the patient often has insomnia and dreaminess, heart-force and pruritus and has yellow complexion; selecting any one group of the above embodiments, placing the composition into a casserole, adding three bowls of water, decocting with medium fire for two hours, taking the decoction orally, three times per day, taking three courses of treatment, one course of treatment lasts for 10 days, and during the treatment period, drinking and pungency are avoided, and more vegetables and fruits are eaten; after the three treatment courses, the face and the body of a patient have no adverse reaction, the sleep quality is improved, the spirit and the mood are improved, the face begins to have blood color, the color of the chloasma is changed into light brown, the patient continues to take the traditional Chinese medicine preparation for three treatment courses, one treatment course lasts for 10 days, the three treatment courses are taken twice every day, the mood is smooth, the insomnia symptom is obviously improved, the face is ruddy, the color of the chloasma is continuously lightened, and the chloasma removing effect is obvious.

Therapeutic example 4

The patients: zhao, women, 50 years old, housewife, symptoms: chloasma appears on the lower eyelid and cheek for seven years, and the color is light black; the patient also takes the capsules for treating menopause and removing freckles in three years, but the effect is not obvious; the diagnosed patients are accompanied with climacteric symptoms such as irritability, dreaminess, serious insomnia and the like; selecting any one group of the above embodiments, placing the composition into a casserole, adding three bowls of water, decocting with medium fire for two hours, taking the decoction orally, three times per day, taking three courses of treatment, one course of treatment lasts for 10 days, and during the treatment period, drinking and pungency are avoided, and more vegetables and fruits are eaten; after the three treatment courses, the face and the body of the patient are not uncomfortable, the patient starts to feel less dream and can fall asleep, the spirit starts to become better, the mood is improved, the color of the chloasma is changed into brown, the patient continues to take the medicine for three treatment courses, one treatment course lasts for 10 days and three times a day, the dreaminess and insomnia symptoms of the patient are obviously improved, the mood of the patient can be controlled, the color of the chloasma is continuously lightened, and the chloasma is removed effectively.

Therapeutic example 5

The patients: wangzhi, male, 40 years old, a social elite; symptoms are: chloasma appears on the face for four years, and the color is light brown; the effect is not ideal when the patients use the spot-lightening cosmetic product; the diagnosed patients have high working pressure and are often compensated for smoking and drinking; selecting any one group of the above embodiments, placing the composition into casserole, adding three bowls of water, decocting with medium fire for two hours, and taking the decoction once a day, with three treatment courses, one treatment course being 10 days, and during the treatment course, drinking and pungency are avoided, and more vegetables and fruits are eaten; after the re-diagnosis, the face of the patient has no discomfort and no adverse effect, the mood is smooth, the color of the chloasma is obviously lightened, the area of the chloasma is reduced, and the effect of treating the chloasma is obvious.

Claims

1. A pharmaceutical composition for treating chloasma is characterized in that: the pharmaceutical composition for treating chloasma is prepared from cortex mori radicis, folium ginkgo, bletilla striata, radix paeoniae alba, radix angelicae, stiff silkworm, radix salviae miltiorrhizae, angelica sinensis, ligusticum wallichii, radix cyathulae, cortex albiziae and scutellaria baicalensis; the weight portions are respectively as follows: 5-25 parts of cortex mori radicis, 5-25 parts of ginkgo leaves, 5-30 parts of bletilla striata, 5-30 parts of radix paeoniae alba, 3-18 parts of radix angelicae, 5-25 parts of stiff silkworm, 5-25 parts of salvia miltiorrhiza, 10-40 parts of angelica sinensis, 5-25 parts of ligusticum wallichii, 5-25 parts of radix cyathulae, 5-25 parts of cortex albiziae and 2-20 parts of scutellaria baicalensis.

2. The pharmaceutical composition for treating chloasma according to claim 1, which is characterized in that: the pharmaceutical composition for treating chloasma comprises the following components in parts by weight: 10-20 parts of cortex mori radicis, 8-20 parts of ginkgo leaves, 10-20 parts of bletilla striata, 10-20 parts of radix paeoniae alba, 5-15 parts of radix angelicae, 8-20 parts of stiff silkworm, 9-20 parts of salvia miltiorrhiza, 15-30 parts of angelica sinensis, 8-20 parts of ligusticum wallichii, 8-20 parts of radix cyathulae, 8-20 parts of cortex albiziae and 5-15 parts of scutellaria baicalensis.

3. The pharmaceutical composition for treating chloasma according to claim 2, which is characterized in that: the pharmaceutical composition for treating chloasma comprises the following components in parts by weight: 12-18 parts of cortex mori radicis, 10-15 parts of ginkgo leaves, 12-18 parts of bletilla striata, 12-18 parts of radix paeoniae alba, 8-12 parts of radix angelicae, 12-18 parts of stiff silkworm, 12-18 parts of salvia miltiorrhiza, 18-25 parts of angelica sinensis, 10-15 parts of ligusticum wallichii, 10-15 parts of radix cyathulae, 10-15 parts of cortex albiziae and 7-12 parts of scutellaria baicalensis.

4. The pharmaceutical composition for treating chloasma according to claim 3, which is characterized in that: the pharmaceutical composition for treating chloasma comprises the following components in parts by weight: 15 parts of cortex mori radicis, 12 parts of ginkgo leaves, 15 parts of bletilla striata, 15 parts of white paeony roots, 9 parts of angelica dahurica, 15 parts of stiff silkworms, 15 parts of salvia miltiorrhiza, 20 parts of angelica, 12 parts of ligusticum wallichii, 12 parts of medicinal cyathula roots, 12 parts of cortex albiziae and 9 parts of scutellaria baicalensis.