CN109999121A

CN109999121A - Treat amblyopia Chinese medicine lotion for external use and preparation method thereof

Info

Publication number: CN109999121A
Application number: CN201910388760.7A
Authority: CN
Inventors: 危苏英
Original assignee: Shenzhen Mingchen Ophthalmic Medical Co Ltd
Current assignee: Shenzhen Mingchen Ophthalmic Medical Co Ltd
Priority date: 2019-05-10
Filing date: 2019-05-10
Publication date: 2019-07-12

Abstract

Amblyopia Chinese medicine lotion for external use and preparation method thereof is treated the invention discloses a kind of.The treatment amblyopia Chinese medicine lotion for external use, is made of: cloves, radix aucklandiae, ageratum, safflower, the dried immature fruit of citron orange, Rhizoma Chuanxiong, butterflybush flower, Radix Notoginseng, ginseng, peppermint, Poria cocos, olibanum, myrrh, the root of Dahurain angelica, Rehmannia glutinosa, cortex moutan, radix achyranthis bidentatae, Semen Cuscutae, cortex cinnamomi, cassia seed, Moschus, mulberry fruit, sliced CORNUS CERVI, dragon's blood, Schisandra chinensis following material.Treatment amblyopia Chinese medicine lotion for external use of the present invention, drug anabolic action be have one's ideas straightened out, stimulate visual development, release visual cortex inhibition, grab amblyopia primary symptom, Biao Litong tune, balance whole body self-regeneration function so that amblyopia eye stablize development and rehabilitation.The present invention treats amblyopia, and not only cure rate is high, cures speed fastly and is not easy to rebound, average only to need for two wheat harvesting period times, and has broken the hopeless saying of adult amblyopia treatment.

Description

Treat amblyopia Chinese medicine lotion for external use and preparation method thereof

Technical field

The present invention relates to field of Chinese herbal medicine technology, more particularly to treatment amblyopia Chinese medicine lotion for external use and preparation method thereof.

Background technique

Currently, amblyopia eye is in China's disease incidence 2%~5%, medically title lazy-eye.In the prior art, one is mostly used A little instrument training and mirror wildcarding correcting, this trained child's difficulty cooperation, need several years, ineffective, or even miss and most preferably control Treatment period.In recent years useful ointment person, as Chinese patent CN201110156969.4 disclose it is a kind of for preventing and treating amblyopia in children Chinese materia medica preparation, raw material composition: Radix Astragali, Rhizoma Atractylodis Macrocephalae mulberry leaf, embryo nelumbinis, pipewort, the low-priced grass of wood, raw hawthorn, feverfew, fructus lycii, Pu Public English, pangolin etc., the function which does not have resuscitation with aromatics, activates amblyopia lazy-eye.Therefore Chinese medicine treatment is green Its effect of juvenile's amblyopia is up for further inquiring into.

It is entitled disclosed in Chinese patent CN201010102314.4 " treat green juvenile's amblyopia, astigmatism, strabismus, myopia, The outer eye ointemnt of visual fatigue ", using the seed of feather cockscomb, Gu Jingzi, raspberry, cassia seed, fructus lycii, butterflybush flower, safflower, mother chrysanthemum Plaster made of flower, Radix Salviae Miltiorrhizae, cimicifugae foetidae, peppermint, storax, calamine, vaseline, atoleine and suitable water.Although the medicine Cream uses a little activating microcirculation and removing stasis medicinal, expansion local vascular, clearing and activating the channels and collaterals, but does not understand the old complaint of amblyopia, and it is flat cannot to start body Weighing apparatus metabolism, the effect of activation eye cell excitement degree, therefore medicinal ointment therapy blueness juvenile amblyopia its effect is up for further inquiring into.

Therefore the method for above-mentioned treatment amblyopia has the disadvantage that

1, the single glasses correction amblyopia time is up to several years, and cure rate is low；

2, single physical apparatus training amblyopia is long, barren between at the moment, and teenager is not easy to cooperate cure rate low；

3, existing ointment forms inclined face, and therapeutic effect needs to be inquired into.

Summary of the invention

The purpose of the present invention is to provide a kind of traditional Chinese medicinal ointments for treating amblyopia eye, cure fast, cure rate height, application method letter Just, easily universal, social value is big for folk prescription.

Amblyopia eye is to belong to depauperation, is belonged to " lazy-eye ", and distance cannot all be seen, is corrected defects of vision for eye optometry It with age due eyesight is amblyopia that his (she), which is not achieved, while binocular visual function lacks that (such as eyes are the same as regarding view, fusion view, vertical The functions such as stereoscopic, pan ability, resolution capability, trace ability lack), it is often accompanied by strabismus.Western medicine is thought mostly by visual development Period a variety of causes causes the effective stimulus of cellula visualis insufficient, to cause visual acuity slow.Traditional Chinese medicine thinks that this disease is Native endowment is insufficient, and very essence is lost less in mesh, and God Light hair is more powerless；Child's improper feeding, with the passing of time then weakness of the spleen and the stomach, qi and blood biochemistry is weary Source can cause loss of nutrient of eyes, blurring of vision.Amblyopia eye seriously affects study, life, work, safety, confidence, psychology etc., early to find Early treatment effect is better.The best treatment age, 12-18 one full year of life cure rate was very low before 8 one full year of life, if cannot cure in time It controls, eyesight and binocular visual function continue to decline with the growth at age, easy blinding after adult.

The comprehensive traditional Chinese and western medicine thinking of the present invention and clinical experience, single cannot be considered certain two organ function it is weak cause it is weak Depending on so ointment of the present invention can improve the five internal organs, Yin Yang balancing, activates lazy cell and bleed blood supports it, and such lazy-eye is just Think actively to see object, meet the effective stimulus of cellula visualis, promote visual cell, vision system excitement levels, light and color can be focused It is clear to regard object in macula lutea, depending on object it is clear after, benign cycle, the visual function that eyes do not develop can be set up, and amblyopia is just calculated Quan Yu；Meanwhile the present invention treats amblyopia not only cure rate is high, it is fast and be not easy to rebound to cure speed, average when only needing two wheat harvesting periods Between, and broken the hopeless saying of adult amblyopia treatment.Therefore, the comprehensive side better than all treatment amblyopias at present of the present invention Method.

The present invention disclose it is a kind of treat amblyopia Chinese medicine lotion for external use, be made of the Chinese medicine material of following mass fraction: cloves 10 ~25 parts, it is 15~35 parts of radix aucklandiae, 10~25 parts of ageratum, 10~25 parts of safflower, 10~25 parts of the dried immature fruit of citron orange, 10~25 parts of Rhizoma Chuanxiong, close Illiteracy spends 10~25 parts, 10~25 parts of Radix Notoginseng, 15~30 parts of ginseng, 10~25 parts of peppermint, 15~30 parts of Poria cocos, olibanum 10~25 Part, 10~25 parts of myrrh, 10~25 parts of the root of Dahurain angelica, 10~25 parts of Rehmannia glutinosa, 10~25 parts of cortex moutan, 10~25 parts, Tu of radix achyranthis bidentatae Sub 15~30 parts, 10~25 parts of cortex cinnamomi, 10~25 parts of cassia seed, 4~15 parts of Moschus, 10~25 parts of mulberry fruit, sliced CORNUS CERVI 2~6 Part, 10~20 parts of dragon's blood, 10~25 parts of Schisandra chinensis.

Further, the treatment amblyopia Chinese medicine lotion for external use, is made of: cloves 10 the Chinese medicine material of following mass fraction Part, 15 parts of radix aucklandiae, 10 parts of ageratum, 10 parts of safflower, 10 parts of the dried immature fruit of citron orange, 10 parts of Rhizoma Chuanxiong, 10 parts of butterflybush flower, 10 parts of Radix Notoginseng, ginseng 15 Part, 10 parts of peppermint, 15 parts of Poria cocos, 10 parts of olibanum, 10 parts of myrrh, 10 parts of the root of Dahurain angelica, 10 parts of Rehmannia glutinosa, 10 parts of cortex moutan, radix achyranthis bidentatae 10 Part, 15 parts of Semen Cuscutae, 10 parts of cortex cinnamomi, 10 parts of cassia seed, 4 parts of Moschus, 10 parts of mulberry fruit, 2 parts of sliced CORNUS CERVI, 10 parts of dragon's blood, the five tastes 10 parts of son.

Further, the treatment amblyopia Chinese medicine lotion for external use, is made of: cloves 25 the Chinese medicine material of following mass fraction Part, 35 parts of radix aucklandiae, 25 parts of ageratum, 25 parts of safflower, 25 parts of the dried immature fruit of citron orange, 25 parts of Rhizoma Chuanxiong, 25 parts of butterflybush flower, 25 parts of Radix Notoginseng, ginseng 30 Part, 25 parts of peppermint, 30 parts of Poria cocos, 25 parts of olibanum, 25 parts of myrrh, 25 parts of the root of Dahurain angelica, 25 parts of Rehmannia glutinosa, 25 parts of cortex moutan, radix achyranthis bidentatae 25 Part, 30 parts of Semen Cuscutae, 25 parts of cortex cinnamomi, 25 parts of cassia seed, 15 parts of Moschus, 25 parts of mulberry fruit, 6 parts of sliced CORNUS CERVI, 20 parts of dragon's blood, the five tastes 25 parts of son.

Further, the treatment amblyopia Chinese medicine lotion for external use, is made of: cloves 15 the Chinese medicine material of following mass fraction Part, 25 parts of radix aucklandiae, 15 parts of ageratum, 15 parts of safflower, 15 parts of the dried immature fruit of citron orange, 15 parts of Rhizoma Chuanxiong, 18 parts of butterflybush flower, 16 parts of Radix Notoginseng, ginseng 20 Part, 16 parts of peppermint, 20 parts of Poria cocos, 18 parts of olibanum, 18 parts of myrrh, 18 parts of the root of Dahurain angelica, 18 parts of Rehmannia glutinosa, 19 parts of cortex moutan, radix achyranthis bidentatae 19 Part, 23 parts of Semen Cuscutae, 20 parts of cortex cinnamomi, 20 parts of the shell of seaear, 15 parts of Moschus, 25 parts of mulberry fruit, 4 parts of sliced CORNUS CERVI, 15 parts of dragon's blood, the five tastes 15 parts of son.

Another technical problem to be solved by this invention is to provide a kind of method for treating amblyopia Chinese medicine lotion for external use, will be above-mentioned The Chinese medicine material of mass number is mixed, and powder material is ground into, and is prepared into ointment using conventional method.

Specifically, the preparation method for the treatment of amblyopia Chinese medicine lotion for external use of the present invention, comprising the following steps:

(1) the Chinese medicine material of above-mentioned mass fraction is mixed, is ground into powder material；The water of 6~12 times of amounts is added, Start to decoct after impregnating 12~24 hours, decocts 1~2 hour, filtrate is then obtained by filtration；When filtrate is condensed into 65~75 DEG C The Chinese medical concrete that relative density is 1.05~1.15；

(2) by 6~20 parts of stearic acid, 50~80 parts of cornstarch, 12~18 parts of glycerol, 10~15 parts of emulsifier and all scholars 8~12 parts of woods mixing, are warming up to 75~85 DEG C, as oily phase；75~85 DEG C are warming up to by 80~130 parts of water, as water phase；It will Oil is added in water phase, is stirred while adding, and after mixing well, obtains matrix；

(3) 40~50 DEG C are naturally cooling to matrix, by Chinese medical concrete, matrix and penetrating agent with mass ratio (4~8): (0.5~2): (0.01~0.05) mixes well to get treatment amblyopia Chinese medicine lotion for external use.

Further, the cornstarch is low-kappa number cornstarch, preparation process are as follows: disperse cornstarch in In ethyl alcohol, it is made into the starch milk of mass fraction 20~30%；Quality is added according to 1~1.5mL/g starch quality under room temperature The concentrated hydrochloric acid of score 35~37% is warming up to 50~60 DEG C after stirring 10~30 minutes, stirs 1~3 hour；Then stop adding Heat, in the sodium carbonate liquor of mass fraction 1~10% and pH to 6.5~6.8, bottom solid is collected in centrifuge separation；By bottom Solid is washed with the ethanol water of volume fraction 50~70%, is dried in vacuo in 40~50 DEG C, and it is beautiful to obtain the low-kappa number Rice starch.

Further, the cornstarch is the preparation process of oxygenation pretreatment cornstarch are as follows: disperses cornstarch in In ethyl alcohol, it is made into the starch milk of mass fraction 5~10%；Under the conditions of 30~40 DEG C, the hydrogen-oxygen of mass fraction 5~10% is added Change sodium water solution, so that the quality of solid sodium hydroxide is the 0.03~0.06% of waxy corn starch quality, is stirred to react 20 ~50 minutes；After reaction, in the hydrochloric acid of mass fraction 1~10% and pH to 6.5~6.8, bottom is collected in centrifuge separation Solid；Bottom solid is washed with the ethanol water of volume fraction 50~70%, is dried in vacuo in 40~50 DEG C, is obtained described Oxygenation pretreatment cornstarch.

Further, the cornstarch is soda acid collaboration pretreatment cornstarch, preparation process are as follows: by cornstarch It is scattered in ethyl alcohol, is made into the starch milk of mass fraction 20~30%；Add under room temperature according to 1~1.5mL/g starch quality Enter the concentrated hydrochloric acid of mass fraction 35~37% and be warming up to 50~60 DEG C after stirring 10~30 minutes, stirs 1~3 hour；Then Stop heating, in the sodium carbonate liquor of mass fraction 1~10% and pH to 6.5~6.8, bottom solid is collected in centrifuge separation； Bottom solid is washed with the ethanol water of volume fraction 50~70%, is dried in vacuo in 40~50 DEG C, it is pre- to obtain the acid Handle cornstarch；It disperses low-kappa number cornstarch in ethyl alcohol, is made into the starch milk of mass fraction 5~10%；30 Under the conditions of~40 DEG C, the sodium hydrate aqueous solution of mass fraction 5~10% is added, so that the quality of solid sodium hydroxide is wax The 0.03~0.06% of cornstarch quality is stirred to react 20~50 minutes；After reaction, with mass fraction 1~10% In hydrochloric acid and bottom solid is collected in pH to 6.5~6.8, centrifuge separation；By the bottom solid ethyl alcohol of volume fraction 50~70% Aqueous solution washing, is dried in vacuo in 40~50 DEG C, obtains the soda acid collaboration pretreatment cornstarch.

Further, the penetrating agent is one of menthol, propylene glycol, azone, barbaloin or a variety of mixtures. Preferably, the mixture that the penetrating agent is menthol, any in propylene glycol, azone and barbaloin forms.It is highly preferred that institute Stating penetrating agent is the mixture that menthol and barbaloin are formed with mass ratio 1:1.

Effect of the invention: treating both manifestation and root cause of disease does not rebound, and amblyopia cure rate is up to 95% or more, and healing time, which is short to, only to be needed It is two months, easy to use, it need to only stick, cost of labor is low.Invention has the beneficial effects that: the ointment in the present invention takes every time 5 grams are divided into 14 equal portions, with desensitization be affixed on Jingming acupoint 2, Pishu Points 2, GB1 2, ophryon point 1, Yongquan acupoint 2, Dazhui acupoint 1, XINYU acupoint 2, Shen Shu point 2, each duration are 4-20 hours, and patch is primary every other day, and 30 days are a treatment Journey, excellent effect and (other myopia corrections without side-effects can be generated by not needing to shop or outpatient service professional gimmick is added to be used together Or the plaster of amblyopia all needs to assist ability effective by professional massage manipulation).

This ointment is convenient to provide the good method of time-saving and efficiency use at home for user, is suitble to 3 years old to 45 years old amblyopia Whole crowds, curer can normally read a book study and work life.The emplastrum time oneself can control, and ointment can be repeatedly secondary Use, will not allergy, stick this plaster can play drug effect and cave effect double effects, can five viscera settling, Yin Yang balancing, rapidly improve view Feel the insufficient situation of cell effective stimulus, promotes eyesight, establish binocular visual function, rapid healing amblyopia, and long-term effect is steady Surely it is not easy to rebound.In addition, cost of labor highest, this ointment does not need professional gimmick auxiliary, and operator can for operator To ask physical therapy technician less, cost of serving is reduced, easy to spread, audience is wide, and social value is high, is different from current all amblyopias The product and plaster of correction, and broken the invalid saying of adult amblyopia treatment.

Specific embodiment

Raw material is described below in embodiment:

Emulsifier, specifically used 721 emulsifier, Guangzhou Yi Jin Biotechnology Co., Ltd, producer.

Acritamer 940, Guangzhou Sheng Xin Chemical Industry Science Co., Ltd, producer, pharmaceutical grade.

Glycerol, hundred Xinda Chemical Co., Ltd. of producer Jinan.

Ethylparaben, Jiangsu Gu Bei Biotechnology Co., Ltd, producer.

Polysorbate, federal Fine Chemical Co., Ltd in producer Guangdong.

Menthol, Guangzhou Chu Ren Chemical Co., Ltd., producer.

Carbomer 934, Guangzhou Sheng Xin Chemical Industry Science Co., Ltd, producer, pharmaceutical grade.

Sodium carboxymethylcellulose, producer's Renqiu City profit reach Chemical Co., Ltd..

Ethyl hydroxy benzoate, the emerging milky way Chemical Co., Ltd. in producer Hubei, pharmaceutical grade.

Macrogol 4000, the bright Chemical Co., Ltd. in producer Guangzhou sincere one.

Polyethylene glycol 400, the bright Chemical Co., Ltd. in producer Guangzhou sincere one.

Waxy corn starch, Foshan City, producer Guo Nong starch Co., Ltd.

Propylene glycol, Guangzhou Guang Chun Chemical Industry Science Co., Ltd, producer, pharmaceutical grade.

Azone, Shaanxi Kang Yue Biotechnology Co., Ltd, producer, pharmaceutical grade.

Barbaloin, Shaanxi Hao Chen Biotechnology Co., Ltd, producer, pharmaceutical grade.

In the case where the present invention does not illustrate, the revolving speed of stirring is 100 revs/min.

In the case where the present invention does not illustrate, room temperature refers to 20~25 DEG C.

Embodiment 1

The treatment amblyopia Chinese medicine lotion for external use, is made of the Chinese medicine material of following mass fraction: 10 parts of cloves, radix aucklandiae 15 Part, 10 parts of ageratum, 10 parts of safflower, 10 parts of the dried immature fruit of citron orange, 10 parts of Rhizoma Chuanxiong, 10 parts of butterflybush flower, 10 parts of Radix Notoginseng, 15 parts of ginseng, peppermint 10 Part, 15 parts of Poria cocos, 10 parts of olibanum, 10 parts of myrrh, 10 parts of the root of Dahurain angelica, 10 parts of Rehmannia glutinosa, 10 parts of cortex moutan, 10 parts of radix achyranthis bidentatae, Semen Cuscutae 15 parts, 10 parts of cortex cinnamomi, 10 parts of cassia seed, 4 parts of Moschus, 10 parts of mulberry fruit, 2 parts of sliced CORNUS CERVI, 10 parts of dragon's blood, 10 parts of Schisandra chinensis.

The formula of the matrix are as follows: 5 parts of Acritamer 940,2 parts of sodium hydroxide, 25 parts of dehydrated alcohol, 25 parts of glycerol, Ni Bo 1 part of golden ethyl ester, 1 part of polysorbate, 120 parts of waxy corn starch, 150 parts of distilled water.

The preparation method of the treatment amblyopia Chinese medicine lotion for external use, comprising the following steps:

(1) the Chinese medicine material of above-mentioned mass fraction is mixed, is ground into 120 mesh powder materials；10 times of amounts are added Water starts to decoct after impregnating 12 hours, decocts 2 hours, filtrate then is obtained by filtration using 200 mesh nylon cloths；Filtrate is concentrated The Chinese medical concrete for being 1.15 at relative density at 75 DEG C；

(2) after Acritamer 940, waxy corn starch and distilled water being sufficiently stirred 24 hours, glycerol and poly- sorb is added Ester, stirring after twenty minutes, are then added ethylparaben and dehydrated alcohol, while sodium hydroxide is added to adjust pH value, obtain The matrix；

(3) Chinese medical concrete, matrix and menthol are mixed well with mass ratio 4:1:0.01 to get in treatment amblyopia external application Ointment.

Embodiment 2

The treatment amblyopia Chinese medicine lotion for external use, is made of the Chinese medicine material of following mass fraction: 25 parts of cloves, radix aucklandiae 35 Part, 25 parts of ageratum, 25 parts of safflower, 25 parts of the dried immature fruit of citron orange, 25 parts of Rhizoma Chuanxiong, 25 parts of butterflybush flower, 25 parts of Radix Notoginseng, 30 parts of ginseng, peppermint 25 Part, 30 parts of Poria cocos, 25 parts of olibanum, 25 parts of myrrh, 25 parts of the root of Dahurain angelica, 25 parts of Rehmannia glutinosa, 25 parts of cortex moutan, 25 parts of radix achyranthis bidentatae, Semen Cuscutae 30 parts, 25 parts of cortex cinnamomi, 25 parts of cassia seed, 15 parts of Moschus, 25 parts of mulberry fruit, 6 parts of sliced CORNUS CERVI, 20 parts of dragon's blood, 25 parts of Schisandra chinensis.

Embodiment 3

The treatment amblyopia Chinese medicine lotion for external use, is made of the Chinese medicine material of following mass fraction: 15 parts of cloves, radix aucklandiae 25 Part, 15 parts of ageratum, 15 parts of safflower, 15 parts of the dried immature fruit of citron orange, 15 parts of Rhizoma Chuanxiong, 18 parts of butterflybush flower, 16 parts of Radix Notoginseng, 20 parts of ginseng, peppermint 16 Part, 20 parts of Poria cocos, 18 parts of olibanum, 18 parts of myrrh, 18 parts of the root of Dahurain angelica, 18 parts of Rehmannia glutinosa, 19 parts of cortex moutan, 19 parts of radix achyranthis bidentatae, Semen Cuscutae 23 parts, 20 parts of cortex cinnamomi, 20 parts of the shell of seaear, 15 parts of Moschus, 25 parts of mulberry fruit, 4 parts of sliced CORNUS CERVI, 15 parts of dragon's blood, 15 parts of Schisandra chinensis.

Embodiment 4

The formula of the matrix are as follows: 5 parts of carbomer 934,2 parts of sodium hydroxide, 25 parts of dehydrated alcohol, 25 parts of glycerol, Ni Bo 1 part of golden ethyl ester, 1 part of polysorbate, 120 parts of waxy corn starch, 150 parts of distilled water.

(2) after carbomer 934, waxy corn starch and distilled water being sufficiently stirred 24 hours, glycerol and poly- sorb is added Ester, stirring after twenty minutes, are then added ethylparaben and dehydrated alcohol, while sodium hydroxide is added to adjust pH value, obtain The matrix；

Embodiment 5

The formula of the matrix are as follows: 5 parts of carbomer 934,2 parts of sodium hydroxide, 25 parts of dehydrated alcohol, 25 parts of glycerol, Ni Bo 1 part of golden ethyl ester, 1 part of polysorbate, 160 parts of waxy corn starch, 200 parts of distilled water.

Embodiment 6

The formula of the matrix are as follows: 7 parts of sodium carboxymethylcellulose, 10 parts of glycerol, 5 parts of dehydrated alcohol, waxy corn starch 50 parts, 83 parts of distilled water, 0.1 part of ethyl hydroxy benzoate.

(2) after twenty minutes by the stirring of sodium carboxymethylcellulose, waxy corn starch and glycerol, dehydrated alcohol, distillation is added Water and ethyl hydroxy benzoate, mix well, and obtain the matrix；

Embodiment 7

The formula of the matrix are as follows: 7 parts of sodium alginate, 5 parts of dehydrated alcohol, 50 parts of waxy corn starch, steams 10 parts of glycerol 83 parts of distilled water, 0.1 part of ethyl hydroxy benzoate.

(2) after twenty minutes by the stirring of sodium alginate, waxy corn starch and glycerol, dehydrated alcohol, distilled water and hydroxyl is added Phenethyl ester mixes well, and obtains the matrix；

Embodiment 8

The formula of the matrix are as follows: 6 parts of stearic acid, 12 parts of glycerol, 15 parts of emulsifier, 10 parts of vaseline, waxy corn form sediment 50 parts of powder, 80 parts of distilled water.

(2) stearic acid, waxy corn starch, glycerol, emulsifier and vaseline are mixed, is warming up to 85 with 2 DEG C/min DEG C, as oily phase；Distilled water is warming up to 85 DEG C with 2 DEG C/min, as water phase；During the oil phase is added to the aqueous phase, stirred when being added It mixes, after mixing well, obtains matrix；

(3) 40 DEG C are naturally cooling to matrix, Chinese medical concrete, matrix and menthol is sufficiently mixed with mass ratio 4:1:0.01 It is even to get treatment amblyopia Chinese medicine lotion for external use.

Embodiment 9

The formula of the matrix are as follows: 2 parts of Macrogol 4000,8 parts of polyethylene glycol 400.

(2) after mixing well Macrogol 4000 and polyethylene glycol 400, matrix is obtained；

Embodiment 10

The formula of the matrix are as follows: 3 parts of Macrogol 4000,7 parts of polyethylene glycol 400.

Embodiment 11

The formula of the matrix are as follows: 4 parts of Macrogol 4000,6 parts of polyethylene glycol 400.

Embodiment 12

The formula of the matrix are as follows: 6 parts of Macrogol 4000,4 parts of polyethylene glycol 400.

Test case 1

Bibliography " Improvement of Preparation for Immiquimod Cream by Orthogonal Test " (Chinese pharmacists, Liu Hong, 2007,10 (8): 798-799) and the document discussion of viscosity " emulsion type ointment base modeling " (Chinese medicine pharmaceutical journal, Zhen Shaoli, 1996,31 (8): 477) treatment amblyopia Chinese medicine lotion for external use is evaluated.Evaluation index is as follows:

Appearance character: smooth, fine and smooth, homogeneous, bubble-free；It is divided into 5 grades, respectively 0,5,10,15,20.

Ductility: pushing open well, is easy to be applied on skin or mucous membrane；It is divided into 5 grades, respectively 0,5,10,15, 20。

Consistency: being divided into 5 grades, and respectively 0,5,10,15,20.

Compatibility of drugs: not changing after drug and matrix compatibility, and thinning equal variation does not occur.Finally split-phase is obtained by four Add, as final score.

Specific test result is shown in Table 1.

1 evaluation test table of table

As it can be seen from table 1 the range of embodiment 4, embodiment 7, the consistency of embodiment 8 and embodiment 9 200~250 It is interior, meet the consistency range of ointment, is preferable matrix selection.And occurs thinning after embodiment 3~5 and compatibility of drugs or become Watery equal disadvantageous changes, so not considering；10~12 mouldability of embodiment and viscosity are general, in conclusion selection is real Applying example 8 is the optimum substrate prescription for treating amblyopia Chinese medicine lotion for external use.

Embodiment 13

The formula of the matrix are as follows: 6 parts of stearic acid, 12 parts of glycerol, 15 parts of emulsifier, 10 parts of vaseline, low-kappa number wax 50 parts of matter cornstarch, 80 parts of distilled water.

(2) stearic acid, low-kappa number waxy corn starch, glycerol, emulsifier and vaseline are mixed, is risen with 2 DEG C/min Temperature is to 85 DEG C, as oily phase；Distilled water is warming up to 85 DEG C with 2 DEG C/min, as water phase；During the oil phase is added to the aqueous phase, Bian Jia Enter side stirring, after mixing well, obtains matrix；

The preparation process of the low-kappa number waxy corn starch are as follows: disperse waxy corn starch in ethyl alcohol, be made into The starch milk of mass fraction 30%；The concentrated hydrochloric acid of mass fraction 35% is added according to 1.4mL/g starch quality under room temperature, stirs After mixing 30 minutes, 50 DEG C are warming up to 2 DEG C/min, is stirred 3 hours；Then stop heating, with the sodium carbonate of mass fraction 10% It with pH to 6.8 in solution, is centrifuged 30 minutes with 4000 revs/min, collects bottom solid；By bottom solid volume fraction 50% Ethanol water washing obtain the low-kappa number wax dry 24 hours under conditions of 45 DEG C, absolute pressure 0.06MPa Matter cornstarch.

Embodiment 14

The formula of the matrix are as follows: 6 parts of stearic acid, 12 parts of glycerol, 15 parts of emulsifier, 10 parts of vaseline, oxygenation pretreatment wax 50 parts of matter cornstarch, 80 parts of distilled water.

(2) stearic acid, oxygenation pretreatment waxy corn starch, glycerol, emulsifier and vaseline are mixed, is risen with 2 DEG C/min Temperature is to 85 DEG C, as oily phase；Distilled water is warming up to 85 DEG C with 2 DEG C/min, as water phase；During the oil phase is added to the aqueous phase, Bian Jia Enter side stirring, after mixing well, obtains matrix；

The preparation process of the oxygenation pretreatment waxy corn starch are as follows: disperse waxy corn starch in ethyl alcohol, be made into The starch milk of mass fraction 10%；Under the conditions of 40 DEG C, the sodium hydrate aqueous solution of mass fraction 10% is added, so that solid hydrogen The quality of sodium oxide molybdena is the 0.06% of waxy corn starch quality, is stirred to react 50 minutes；After reaction, mass fraction is used It with pH to 6.8 in 10% hydrochloric acid, is centrifuged 30 minutes with 4000 revs/min, collects bottom solid；By bottom solid volume point The ethanol water of number 50% washs, 24 hours dry under conditions of 45 DEG C, absolute pressure 0.06MPa, and it is pre- to obtain the alkali Handle waxy corn starch.

Embodiment 15

The formula of the matrix are as follows: 6 parts of stearic acid, 12 parts of glycerol, 15 parts of emulsifier, 10 parts of vaseline, soda acid collaboration are pre- Handle 50 parts of waxy corn starch, 80 parts of distilled water.

(2) stearic acid, soda acid collaboration pretreatment waxy corn starch, glycerol, emulsifier and vaseline are mixed, with 2 DEG C/ Minute is warming up to 85 DEG C, as oily phase；Distilled water is warming up to 85 DEG C with 2 DEG C/min, as water phase；The oil phase is added to the aqueous phase In, it stirs while adding, after mixing well, obtains matrix；

The preparation process of the soda acid collaboration pretreatment waxy corn starch are as follows: disperse ethyl alcohol for waxy corn starch In, it is made into the starch milk of mass fraction 30%；The dense of mass fraction 35% is added according to 1.4mL/g starch quality under room temperature Hydrochloric acid after stirring 30 minutes, is warming up to 50 DEG C with 2 DEG C/min, stirs 3 hours；Then stop heating, with mass fraction 10% Sodium carbonate liquor in and pH to 6.8, with 4000 revs/min be centrifuged 30 minutes, collect bottom solid；By bottom solid volume The ethanol water of score 50% washs, 24 hours dry under conditions of 45 DEG C, absolute pressure 0.06MPa, obtains the acid Pre-process waxy corn starch；It disperses low-kappa number waxy corn starch in ethyl alcohol, is made into the starch of mass fraction 10% Cream；Under the conditions of 40 DEG C, the sodium hydrate aqueous solution of mass fraction 10% is added, so that the quality of solid sodium hydroxide is that acid is pre- The 0.06% of waxy corn starch quality is handled, is stirred to react 50 minutes；After reaction, in the hydrochloric acid with mass fraction 10% It with pH to 6.8, is centrifuged 30 minutes with 4000 revs/min, collects bottom solid；By the bottom solid ethyl alcohol of volume fraction 50% Aqueous solution washing, it is 24 hours dry under conditions of 45 DEG C, absolute pressure 0.06MPa, obtain the soda acid collaboration pretreatment wax Matter cornstarch.

Test case 2

Selecting the small degree strabismic amblyopia infant accepted for medical treatment between on June 31,1 day to 2016 June in 2015 is object, All infant state of an illness are consistent with what Chinese Medical Association formulated about small degree strabismic amblyopia diagnostic criteria, and there are different journeys Dysopia is spent, all family numbers of patients are to the equal informed consent of this research.It excludes to this group of therapeutic scheme sensitive subjects, there are it for exclusion He is Organic and communicable disease person.Wherein, men and women is fifty-fifty, and slight amblyopia accounts for 45%, and moderate amblyopia accounts for 34%, moderate and severe degree of amblyopia Account for 21%.

Treatment method: the treatment amblyopia Chinese medicine lotion for external use in the present invention takes 5 grams to be divided into 14 equal portions every time, is affixed on desensitization Jingming acupoint 2, Pishu Points 2, GB1 2, ophryon point 1, Yongquan acupoint 2, Dazhui acupoint 1, XINYU acupoint 2, Shen Shu point 2 A, each duration is 20 hours, and patch is primary every other day, 30 days as a treatment course.After one course for the treatment of, curative effect is counted.

Efficacy determination: the amblyopia correction >=0.9 of infant after treatment；Improve: the amblyopia of infant corrects >=2 rows after treatment；Nothing Effect: the amblyopia of infant corrects 2 row of < after treatment.Effective percentage=cure rate+improvement rate.Concrete operations are referring to " Comprehensive Therapy for Treatment The Clinical efficacy of the small degree strabismic amblyopia of children " (Chinese Medicine guide, Li Renda, 2017,15 (30): 44-45).

Specific test result is shown in Table 2.

2 amblyopia treating effect of table tests table

From table 2 it can be seen that light, moderate amblyopia therapeutic effect is obviously compared with the therapeutic effect of moderate and severe degree of amblyopia significantly (P < 0.05).In conclusion the treatment amblyopia Chinese medicine lotion for external use in the present invention is used to small degree strabismic amblyopia patient, for Gently, moderate amblyopia treating effect is more preferably.Wherein the therapeutic effect of embodiment 13 and embodiment 15 is preferable, may be because at acid There is aperture in the cornstarch surface of reason, increases hot cold bonding degree ratio while increasing specific surface area, improves its gelation；And it is sour The cornstarch of alkali collaboration processing expands lye in acid treated starch, so that starch sufficiently activates, further Improve its swelling behavior.

Embodiment 16

(3) 40 DEG C are naturally cooling to matrix, Chinese medical concrete, matrix and propylene glycol is sufficiently mixed with mass ratio 4:1:0.01 It is even to get treatment amblyopia Chinese medicine lotion for external use.

The same embodiment 15 of the soda acid collaboration pretreatment waxy corn starch.

Embodiment 17

(3) 40 DEG C are naturally cooling to matrix, Chinese medical concrete, matrix and azone is sufficiently mixed with mass ratio 4:1:0.01 It is even to get treatment amblyopia Chinese medicine lotion for external use.

Embodiment 18

(3) 40 DEG C are naturally cooling to matrix, Chinese medical concrete, matrix and penetrating agent is sufficiently mixed with mass ratio 4:1:0.01 It is even to get treatment amblyopia Chinese medicine lotion for external use.

The penetrating agent is the mixture that barbaloin and menthol are formed with mass ratio 1:1.

Embodiment 19

The penetrating agent is barbaloin and the mixture that propylene glycol is formed with mass ratio 1:1.

Embodiment 20

The penetrating agent is the mixture that barbaloin and azone are formed with mass ratio 1:1.

Test case 3

It is external in reference literature " dencichine extracts Separation Research and the evaluation of transdermal penetration performance in notoginseng haulm " (Li Lin) Percutaneous test method is measured dencichine by the penetrating agent in embodiment 15~20 by the permeability of mouse skin respectively.

Specific test result is shown in Table 3.

3 dencichine transdermal penetration measure of merit table of table

From table 3 it can be seen that compared with traditional penetrating agent menthol, azone and propylene glycol, barbaloin and menthol joint In use, the skin milliosmolarity of dencichine significantly increases.

Test case 4

Skin irritation test is carried out to treatment amblyopia Chinese medicine lotion for external use described in embodiment 18.

Experimental animal: Wistar rat is provided by Laboratory Animal Center of Jilin University, and SPF grades, half male and half female, weight 200- 220g, 5-8 week old, credit number SCXK- (Ji) 2014-0003.

Animal packet processing: selection health Wistar rat 100 (half male and half female), each test include intact skin group With damaged skin group, each group is randomly divided into physiological saline group, treatment amblyopia Chinese medicine lotion for external use low dose group (each 0.2g again kg^-1), treatment amblyopia Chinese medicine lotion for external use middle dose group (each 0.4gkg^-1), treatment amblyopia Chinese medicine lotion for external use high dose group it is (every Secondary 1.0gkg^-1), every group 5, rat spine two sides coat is wiped out with scissors for 24 hours before administration, then uniformly smears depilation Cream after several minutes, is stained with warm water for depilatory agent and the hair wash clean together that falls off with sliver, area about 2.5cm × 2.5cm, unhairing is for 24 hours It checks whether unhairing area skin has damage afterwards, is preferred with no erythema, redness and breakage.Damaged skin irritation test needs Damaged skin model is established, cross spider is drawn on depilation skin with the syringe needle after disinfection, is degree to scratch the slight oozing of blood of cuticula, And guarantee that the damaged degree of two sides rat skin is consistent.

4.1 single administration skin irritation tests

With the method for skin comparison at left and right sides of rat itself, each rats with left that is grouped smears corresponding test sample respectively, Right side is motionless to be can be used for compareing.It will be fixed at rat skin medication after medication, in order to avoid fall off.After for 24 hours, gauze is taken Under, the skin of rat medication is cleaned with physiological saline, after removing drug 1h, for 24 hours, 48h, 72h carry out situation and above-mentioned The recovery situation of variation, and score.

4.2 multiple dosing Skin Irritation Tests

With the method for skin comparison at left and right sides of rat itself, each rats with left that is grouped smears corresponding test sample respectively, Right side is motionless to be can be used for compareing.It will be fixed at rat skin medication after medication, in order to avoid falling off, daily medication 2 times is continuous to smear 7d.The 1h after removal drug every time, observe and record smear position whether there is or not erythema and it is red and swollen situations such as, and score.

Experimental result

4.1 single administration skin irritation tests

As a result, it has been found that being erythema and redness occur in single administration intact skin irritant experiment in each group rat 72h Situations such as；Amblyopia Chinese medicine lotion for external use low, middle and high dose groups are treated in single administration damaged skin irritation test in removal drug 1h Have 1 rat skin micro- red respectively afterwards, for 24 hours after subside, all smearing positions of other groups of rats do not occur erythema, oedema； 24, when 48,72h situation and when 1h observation it is consistent, no significant change is divided according to skin wound repair series, is belonged to stingless Swash property.

4.2 multiple dosing skin irritation tests

As a result, it has been found that being erythema and redness occur in multiple dosing intact skin irritant experiment in each group rat 7d Situations such as；1 rat of amblyopia Chinese medicine lotion for external use high dose and treatment amblyopia are treated in the treatment of multiple dosing damaged skin irritation test 2 rats of Chinese medicine lotion for external use middle dose group occur that skin is micro- red, and phenomenon subsides in 3d when 1d removes tested material, other groups All smearing positions of rat do not occur erythema, oedema；Situation is consistent with observation when 1d when 3,5,7d, no significant change, according to Skin wound repair series divides, and belongs to nonirritant.

Specific test result see the table below.

4.1 single administration intact skin irritation appraisal result of table

Group	1h	24h	48h	72h	Stimulation evaluation
						Physiological saline group	0	0	0	0	It is nonirritant
Low dose group	0	0	0	0	It is nonirritant
						Middle dose group	0	0	0	0	It is nonirritant
High dose group	0	0	0	0	It is nonirritant

4.2 single administration damaged skin irritation appraisal result of table

4.3 multiple dosing intact skin irritation appraisal result of table

Group	1d	3d	5d	7d	Stimulation evaluation
						Physiological saline group	0	0	0	0	It is nonirritant
Low dose group	0.5	0	0	0	It is nonirritant
						Middle dose group	0	0	0	0	It is nonirritant
High dose group	0	0	0	0	It is nonirritant

4.4 multiple dosing damaged skin irritation appraisal result of table

Group	1d	3d	5d	7d	Stimulation evaluation
						Physiological saline group	0	0	0	0	It is nonirritant
Low dose group	0	0	0	0	It is nonirritant
						Middle dose group	1	0	0	0	It is nonirritant
High dose group	0.5	0	0	0	It is nonirritant

From table 4.1~4.4 as can be seen that it is complete to establish rat using the method compared at left and right sides of rat autologous skin Property skin model and destructive skin model, carry out cutaneous safety test.The result shows that each group rat does not occur any thorn Swash property and allergic reaction, in 1h, for 24 hours, to examine integral summation again be 0 by 48h, 72h, belong to non-stimulated no anaphylaxis.

It should be appreciated that although this specification is described in terms of embodiments, but not each embodiment only includes one A independent technical solution, for the sake of this narrating mode of specification is used for the purpose of clearly, those skilled in the art should be incited somebody to action As a whole, the technical solutions in the various embodiments may also be suitably combined for specification, and forming those skilled in the art can With the other embodiments of understanding.

Claims

1. treating amblyopia Chinese medicine lotion for external use, which is characterized in that be made of the Chinese medicine material of following mass fraction: cloves 10~25 Part, 15~35 parts of radix aucklandiae, 10~25 parts of ageratum, 10~25 parts of safflower, 10~25 parts of the dried immature fruit of citron orange, 10~25 parts of Rhizoma Chuanxiong, butterflybush flower 10~25 parts, 10~25 parts of Radix Notoginseng, 15~30 parts of ginseng, 10~25 parts of peppermint, 15~30 parts of Poria cocos, 10~25 parts of olibanum, do not have 10~25 parts of medicine, 10~25 parts of the root of Dahurain angelica, 10~25 parts of Rehmannia glutinosa, 10~25 parts of cortex moutan, 10~25 parts of radix achyranthis bidentatae, Semen Cuscutae 15~ 30 parts, 10~25 parts of cortex cinnamomi, 10~25 parts of cassia seed, 4~15 parts of Moschus, 10~25 parts of mulberry fruit, 2~6 parts of sliced CORNUS CERVI, dragon's blood 10~20 parts, 10~25 parts of Schisandra chinensis.

2. treatment amblyopia Chinese medicine lotion for external use according to claim 1, which is characterized in that by the middle drug of following mass fraction Material composition: 10 parts of cloves, 15 parts of radix aucklandiae, 10 parts of ageratum, 10 parts of safflower, 10 parts of the dried immature fruit of citron orange, 10 parts of Rhizoma Chuanxiong, 10 parts of butterflybush flower, three 7 10 parts, 15 parts of ginseng, 10 parts of peppermint, 15 parts of Poria cocos, 10 parts of olibanum, 10 parts of myrrh, 10 parts of the root of Dahurain angelica, 10 parts of Rehmannia glutinosa, tree peony 10 parts of skin, 10 parts of radix achyranthis bidentatae, 15 parts of Semen Cuscutae, 10 parts of cortex cinnamomi, 10 parts of cassia seed, 4 parts of Moschus, 10 parts of mulberry fruit, 2 parts of sliced CORNUS CERVI, 10 parts of dragon's blood, 10 parts of Schisandra chinensis.

3. treatment amblyopia Chinese medicine lotion for external use according to claim 1, which is characterized in that by the middle drug of following mass fraction Material composition: 25 parts of cloves, 35 parts of radix aucklandiae, 25 parts of ageratum, 25 parts of safflower, 25 parts of the dried immature fruit of citron orange, 25 parts of Rhizoma Chuanxiong, 25 parts of butterflybush flower, three 7 25 parts, 30 parts of ginseng, 25 parts of peppermint, 30 parts of Poria cocos, 25 parts of olibanum, 25 parts of myrrh, 25 parts of the root of Dahurain angelica, 25 parts of Rehmannia glutinosa, tree peony 25 parts of skin, 25 parts of radix achyranthis bidentatae, 30 parts of Semen Cuscutae, 25 parts of cortex cinnamomi, 25 parts of cassia seed, 15 parts of Moschus, 25 parts of mulberry fruit, 6 parts of sliced CORNUS CERVI, 20 parts of dragon's blood, 25 parts of Schisandra chinensis.

4. treatment amblyopia Chinese medicine lotion for external use according to claim 1, which is characterized in that by the middle drug of following mass fraction Material composition: 15 parts of cloves, 25 parts of radix aucklandiae, 15 parts of ageratum, 15 parts of safflower, 15 parts of the dried immature fruit of citron orange, 15 parts of Rhizoma Chuanxiong, 18 parts of butterflybush flower, three 7 16 parts, 20 parts of ginseng, 16 parts of peppermint, 20 parts of Poria cocos, 18 parts of olibanum, 18 parts of myrrh, 18 parts of the root of Dahurain angelica, 18 parts of Rehmannia glutinosa, tree peony 19 parts of skin, 19 parts of radix achyranthis bidentatae, 23 parts of Semen Cuscutae, 20 parts of cortex cinnamomi, 20 parts of the shell of seaear, 15 parts of Moschus, 25 parts of mulberry fruit, 4 parts of sliced CORNUS CERVI, 15 parts of dragon's blood, 15 parts of Schisandra chinensis.

5. the method for preparing treatment amblyopia Chinese medicine lotion for external use as described in any one of claims 1 to 4, which is characterized in that will The Chinese medicine material of above-mentioned mass number is mixed, and powder material is ground into, and is prepared into ointment using conventional method.

6. the preparation method for the treatment of amblyopia Chinese medicine lotion for external use according to claim 5, which is characterized in that including following step It is rapid:

(1) the Chinese medicine material of above-mentioned mass fraction is mixed, is ground into powder material；The water of 6~12 times of amounts is added, impregnates Start to decoct after 12~24 hours, decocts 1~2 hour, filtrate is then obtained by filtration；It is opposite when filtrate is condensed into 65~75 DEG C The Chinese medical concrete that density is 1.05~1.15；

(2) by 6~20 parts of stearic acid, 50~80 parts of cornstarch, 12~18 parts of glycerol, 10~15 parts of emulsifier and vaseline 8 ~12 parts of mixing, are warming up to 75~85 DEG C, as oily phase；75~85 DEG C are warming up to by 80~130 parts of water, as water phase；It will be oily It is added in water phase, stirs while adding, after mixing well, obtain matrix；

(3) 40~50 DEG C are naturally cooling to matrix, by Chinese medical concrete, matrix and penetrating agent with mass ratio (4~8): (0.5~ 2): (0.01~0.05) mixes well to get treatment amblyopia Chinese medicine lotion for external use.

7. the preparation method for the treatment of amblyopia Chinese medicine lotion for external use according to claim 6, which is characterized in that the cornstarch For low-kappa number cornstarch, preparation process are as follows: disperse cornstarch in ethyl alcohol, be made into mass fraction 20~30% Starch milk；Under room temperature according to 1~1.5mL/g starch quality be added mass fraction 35~37% concentrated hydrochloric acid, stirring 10~ After 30 minutes, 50~60 DEG C are warming up to, is stirred 1~3 hour；Then stop heating, the sodium carbonate with mass fraction 1~10% is molten In liquid and bottom solid is collected in pH to 6.5~6.8, centrifuge separation；By the bottom solid ethanol water of volume fraction 50~70% Solution washing, is dried in vacuo in 40~50 DEG C, obtains the low-kappa number cornstarch.

8. the preparation method for the treatment of amblyopia Chinese medicine lotion for external use according to claim 6, which is characterized in that the cornstarch For the preparation process of oxygenation pretreatment cornstarch are as follows: disperse cornstarch in ethyl alcohol, be made into the shallow lake of mass fraction 5~10% Powder cream；Under the conditions of 30~40 DEG C, the sodium hydrate aqueous solution of mass fraction 5~10% is added, so that solid sodium hydroxide Quality is the 0.03~0.06% of waxy corn starch quality, is stirred to react 20~50 minutes；After reaction, mass fraction is used In 1~10% hydrochloric acid and bottom solid is collected in pH to 6.5~6.8, centrifuge separation；By bottom solid with volume fraction 50~ 70% ethanol water washing, is dried in vacuo in 40~50 DEG C, obtains the oxygenation pretreatment cornstarch.

9. the preparation method for the treatment of amblyopia Chinese medicine lotion for external use according to claim 6, which is characterized in that the cornstarch For soda acid cooperate with pretreatment cornstarch, preparation process are as follows: disperse cornstarch in ethyl alcohol, be made into mass fraction 20~ 30% starch milk；The concentrated hydrochloric acid of mass fraction 35~37% is added according to 1~1.5mL/g starch quality under room temperature, stirs After mixing 10~30 minutes, 50~60 DEG C are warming up to, is stirred 1~3 hour；Then stop heating, with the carbon of mass fraction 1~10% In acid sodium solution and bottom solid is collected in pH to 6.5~6.8, centrifuge separation；By bottom solid volume fraction 50~70% Ethanol water washing, is dried in vacuo in 40~50 DEG C, obtains the low-kappa number cornstarch；By low-kappa number cornstarch It is scattered in ethyl alcohol, is made into the starch milk of mass fraction 5~10%；Under the conditions of 30~40 DEG C, mass fraction 5~10% is added Sodium hydrate aqueous solution so that the quality of solid sodium hydroxide be waxy corn starch quality 0.03~0.06%, stirring Reaction 20~50 minutes；After reaction, it is received in the hydrochloric acid of mass fraction 1~10% with pH to 6.5~6.8, centrifuge separation Collect bottom solid；Bottom solid is washed with the ethanol water of volume fraction 50~70%, is dried in vacuo, obtains in 40~50 DEG C Pretreatment cornstarch is cooperateed with to the soda acid.

10. the preparation method for the treatment of amblyopia Chinese medicine lotion for external use according to claim 6, which is characterized in that the penetrating agent For one of menthol, propylene glycol, azone, barbaloin or a variety of mixtures.